Journal Article
. 2006 May;24(23).
doi: 10.1200/JCO.2005.04.7985.

Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer

Soonmyung Paik 1 Gong Tang  Steven Shak  Chungyeul Kim  Joffre Baker  Wanseop Kim  Maureen Cronin  Frederick L Baehner  Drew Watson  John Bryant  Joseph P Costantino  Charles E Geyer  D Lawrence Wickerham  Norman Wolmark  
Affiliations
  • PMID: 16720680
  •     769 citations

Abstract

Purpose: The 21-gene recurrence score (RS) assay quantifies the likelihood of distant recurrence in women with estrogen receptor-positive, lymph node-negative breast cancer treated with adjuvant tamoxifen. The relationship between the RS and chemotherapy benefit is not known.

Methods: The RS was measured in tumors from the tamoxifen-treated and tamoxifen plus chemotherapy-treated patients in the National Surgical Adjuvant Breast and Bowel Project (NSABP) B20 trial. Cox proportional hazards models were utilized to test for interaction between chemotherapy treatment and the RS.

Results: A total of 651 patients were assessable (227 randomly assigned to tamoxifen and 424 randomly assigned to tamoxifen plus chemotherapy). The test for interaction between chemotherapy treatment and RS was statistically significant (P = .038). Patients with high-RS (> or = 31) tumors (ie, high risk of recurrence) had a large benefit from chemotherapy (relative risk, 0.26; 95% CI, 0.13 to 0.53; absolute decrease in 10-year distant recurrence rate: mean, 27.6%; SE, 8.0%). Patients with low-RS (< 18) tumors derived minimal, if any, benefit from chemotherapy treatment (relative risk, 1.31; 95% CI, 0.46 to 3.78; absolute decrease in distant recurrence rate at 10 years: mean, -1.1%; SE, 2.2%). Patients with intermediate-RS tumors did not appear to have a large benefit, but the uncertainty in the estimate can not exclude a clinically important benefit.

Conclusion: The RS assay not only quantifies the likelihood of breast cancer recurrence in women with node-negative, estrogen receptor-positive breast cancer, but also predicts the magnitude of chemotherapy benefit.

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Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?
Mathew Purdom, Michael L Cibull, +4 authors, Rouzan G Karabakhtsian.
Patholog Res Int, 2010 Dec 15; 2011. PMID: 21151541    Free PMC article.
Are current development programs realising the full potential of new agents?
Per Eystein Lønning.
Breast Cancer Res, 2011 Jan 05; 12 Suppl 4. PMID: 21172086    Free PMC article.
Molecular profiling currently offers no more than tumour morphology and basic immunohistochemistry.
Britta Weigelt, Jorge S Reis-Filho.
Breast Cancer Res, 2011 Jan 05; 12 Suppl 4. PMID: 21172089    Free PMC article.
Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX Colon Cancer Assay.
Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson.
BMC Cancer, 2010 Dec 24; 10. PMID: 21176237    Free PMC article.
Postoperative fever: the potential relationship with prognosis in node negative breast cancer patients.
Tingting Yan, Wenjin Yin, +4 authors, Jinsong Lu.
PLoS One, 2011 Jan 07; 5(12). PMID: 21209958    Free PMC article.
Comparison of the prognostic and predictive utilities of the 21-gene Recurrence Score assay and Adjuvant! for women with node-negative, ER-positive breast cancer: results from NSABP B-14 and NSABP B-20.
Gong Tang, Steven Shak, +6 authors, Norman Wolmark.
Breast Cancer Res Treat, 2011 Jan 12; 127(1). PMID: 21221771    Free PMC article.
Health care reform: how personalized medicine could help bundling of care for liver diseases.
Lopa Mishra.
Hepatology, 2011 Jan 29; 53(2). PMID: 21274858    Free PMC article.
Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer.
Lisa M Arendt, Debra E Rugowski, +3 authors, Linda A Schuler.
Breast Cancer Res, 2011 Feb 01; 13(1). PMID: 21276249    Free PMC article.
Differential efficacy of three cycles of CMF followed by tamoxifen in patients with ER-positive and ER-negative tumors: long-term follow up on IBCSG Trial IX.
S Aebi, Z Sun, +14 authors, A Goldhirsch.
Ann Oncol, 2011 Feb 02; 22(9). PMID: 21282282    Free PMC article.
Physical and psychosocial recovery in the year after primary treatment of breast cancer.
Patricia A Ganz, Lorna Kwan, +2 authors, Thomas R Belin.
J Clin Oncol, 2011 Feb 09; 29(9). PMID: 21300931    Free PMC article.
Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial.
Armando E Giuliano, Kelly K Hunt, +7 authors, Monica Morrow.
JAMA, 2011 Feb 10; 305(6). PMID: 21304082    Free PMC article.
Highly Cited.
Measuring the performance of markers for guiding treatment decisions.
Holly Janes, Margaret S Pepe, Patrick M Bossuyt, William E Barlow.
Ann Intern Med, 2011 Feb 16; 154(4). PMID: 21320940    Free PMC article.
Can some patients avoid adjuvant chemotherapy for early-stage breast cancer?
Philippe L Bedard, Fatima Cardoso.
Nat Rev Clin Oncol, 2011 Mar 03; 8(5). PMID: 21364525
Review.
Early breast cancer in the older woman.
Sonal Gandhi, Sunil Verma.
Oncologist, 2011 Mar 19; 16(4). PMID: 21415085    Free PMC article.
Review.
Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes?
Yotam Drier, Eytan Domany.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423753    Free PMC article.
Mass spectrometric characterization of protein structure details refines the proteome signature for invasive ductal breast carcinoma.
Claudia Röwer, Cornelia Koy, +4 authors, Michael O Glocker.
J Am Soc Mass Spectrom, 2011 Apr 08; 22(3). PMID: 21472563
Tamoxifen in early-stage estrogen receptor-positive breast cancer: overview of clinical use and molecular biomarkers for patient selection.
Carmen Criscitiello, Debora Fumagalli, Kamal S Saini, Sherene Loi.
Onco Targets Ther, 2011 May 10; 4. PMID: 21552410    Free PMC article.
Preoperative chemotherapy for operable breast cancer improves surgical outcomes in the community hospital setting.
Ian K Komenaka, Michael L Hibbard, +4 authors, Chandra Jha.
Oncologist, 2011 May 12; 16(6). PMID: 21558133    Free PMC article.
Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients.
Ian K Komenaka, Chiu-Hsieh Hsu, +6 authors, Chandra Jha.
Oncologist, 2011 May 12; 16(6). PMID: 21558134    Free PMC article.
Adjuvant chemotherapy for breast cancer in older women: emerging evidence to aid in decision making.
Gretchen Kimmick.
Curr Treat Options Oncol, 2011 Jun 04; 12(3). PMID: 21638199
Review.
Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
Yuh-Charn Lin, Chun-Chuan Chen, Chien-Jui Cheng, Ruey-Bing Yang.
J Biol Chem, 2011 Jun 10; 286(30). PMID: 21652720    Free PMC article.
Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer.
Wendy Weijia Soon, Lance David Miller, +7 authors, Edison T Liu.
EMBO Mol Med, 2011 Jun 10; 3(8). PMID: 21656687    Free PMC article.
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence.
James L Chen, Jianrong Li, Walter M Stadler, Yves A Lussier.
J Am Med Inform Assoc, 2011 Jun 16; 18(4). PMID: 21672909    Free PMC article.
The changing role of pathology in breast cancer diagnosis and treatment.
Anthony S-Y Leong, Zhengping Zhuang.
Pathobiology, 2011 Jun 17; 78(2). PMID: 21677473    Free PMC article.
Review.
Gene expression profile testing for breast cancer and the use of chemotherapy, serious adverse effects, and costs of care.
Jennifer S Haas, Su-Ying Liang, +3 authors, Kathryn A Phillips.
Breast Cancer Res Treat, 2011 Jun 18; 130(2). PMID: 21681446    Free PMC article.
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.
A Goldhirsch, W C Wood, +4 authors, Panel members.
Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140    Free PMC article.
Highly Cited.
Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples.
Fathi Elloumi, Zhiyuan Hu, +4 authors, Melissa A Troester.
BMC Med Genomics, 2011 Jul 02; 4. PMID: 21718502    Free PMC article.
Physician survey of the effect of the 21-gene recurrence score assay results on treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer.
Ruth Oratz, Benjamin Kim, +4 authors, Michael Broder.
J Oncol Pract, 2011 Jul 07; 7(2). PMID: 21731516    Free PMC article.
High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials.
Donald A Berry, Naoto T Ueno, +21 authors, Taner Demirer.
J Clin Oncol, 2011 Jul 20; 29(24). PMID: 21768471    Free PMC article.
Prognostic and Predictive Markers for Treatment Decisions in Early Breast Cancer.
Elmar Stickeler.
Breast Care (Basel), 2011 Jul 23; 6(3). PMID: 21779224    Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction.
Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho.
Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441    Free PMC article.
Review.
Predictive and prognostic molecular markers for cancer medicine.
Sunali Mehta, Andrew Shelling, +4 authors, Cristin Print.
Ther Adv Med Oncol, 2010 Mar 01; 2(2). PMID: 21789130    Free PMC article.
A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer.
Suleiman Massarweh, Yee L Tham, +9 authors, Richard Elledge.
Breast Cancer Res Treat, 2011 Jul 28; 129(3). PMID: 21792626    Free PMC article.
Challenges in the management of stage II colon cancer.
Efrat Dotan, Steven J Cohen.
Semin Oncol, 2011 Aug 04; 38(4). PMID: 21810510    Free PMC article.
Review.
SEOM clinical guidelines for using molecular markers in clinical practice.
Virginia Arrazubi, Roberto Pazo, Dolores Isla, José Luis Pérez Gracia.
Clin Transl Oncol, 2011 Aug 09; 13(8). PMID: 21821495
Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence.
Mary Jo Fackler, Christopher B Umbricht, +13 authors, Saraswati Sukumar.
Cancer Res, 2011 Aug 10; 71(19). PMID: 21825015    Free PMC article.
Highly Cited.
Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
Robin K Kelley, Alan P Venook.
Clin Colorectal Cancer, 2011 Aug 24; 10(2). PMID: 21859557    Free PMC article.
Review.
Genomic testing and therapies for breast cancer in clinical practice.
Jennifer S Haas, Kathryn A Phillips, +5 authors, Michele Toscano.
J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886507    Free PMC article.
US Insurance Program's Experience With a Multigene Assay for Early-Stage Breast Cancer.
John Hornberger, Rebecca Chien, Katie Krebs, Louis Hochheiser.
J Oncol Pract, 2011 Sep 03; 7(3 Suppl). PMID: 21886510    Free PMC article.
Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score.
Arif H Kamal, Charles L Loprinzi, +7 authors, Matthew P Goetz.
Oncologist, 2011 Sep 22; 16(10). PMID: 21934103    Free PMC article.
Estrogen receptor (ESR1) mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen receptor-positive breast cancer.
Chungyeul Kim, Gong Tang, +18 authors, Soonmyung Paik.
J Clin Oncol, 2011 Sep 29; 29(31). PMID: 21947828    Free PMC article.
Recent progress and clinical importance on pharmacogenetics in cancer therapy.
Thomas I Peng Soh, Wei Peng Yong, Federico Innocenti.
Clin Chem Lab Med, 2011 Sep 29; 49(10). PMID: 21950596    Free PMC article.
Review.
Improving communication of breast cancer recurrence risk.
Noel T Brewer, Alice R Richman, +2 authors, Lisa A Carey.
Breast Cancer Res Treat, 2011 Oct 04; 133(2). PMID: 21964579    Free PMC article.
Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer.
H Wong, S Lau, +6 authors, T Yau.
Med Oncol, 2011 Oct 11; 29(3). PMID: 21983862
Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer.
Rachel C Jankowitz, Kristine Cooper, +5 authors, Adam Brufsky.
Breast Cancer Res, 2011 Oct 18; 13(5). PMID: 21999244    Free PMC article.
Risk of recurrence and chemotherapy benefit for patients with node-negative, estrogen receptor-positive breast cancer: recurrence score alone and integrated with pathologic and clinical factors.
Gong Tang, Jack Cuzick, +6 authors, Norman Wolmark.
J Clin Oncol, 2011 Oct 20; 29(33). PMID: 22010013    Free PMC article.
The effect of Oncotype DX recurrence score on treatment recommendations for patients with estrogen receptor-positive early stage breast cancer and correlation with estimation of recurrence risk by breast cancer specialists.
Jennifer E Joh, Nicole N Esposito, +10 authors, Geza Acs.
Oncologist, 2011 Oct 22; 16(11). PMID: 22016474    Free PMC article.
Impact of multigene assays in early stage breast cancer.
Shelly S Lo, Kathy S Albain.
Oncologist, 2011 Oct 22; 16(11). PMID: 22016475    Free PMC article.
Hormone receptor and ERBB2 status in gene expression profiles of human breast tumor samples.
Anna Dvorkin-Gheva, John A Hassell.
PLoS One, 2011 Oct 25; 6(10). PMID: 22022496    Free PMC article.
Protein expression, survival and docetaxel benefit in node-positive breast cancer treated with adjuvant chemotherapy in the FNCLCC-PACS 01 randomized trial.
Jocelyne Jacquemier, Jean-Marie Boher, +12 authors, François Bertucci.
Breast Cancer Res, 2011 Nov 03; 13(6). PMID: 22044691    Free PMC article.
Biologic characteristics of premalignant breast disease.
Kimberly Cole, Maria Tabernero, Karen S Anderson.
Cancer Biomark, 2011 Nov 25; 9(1-6). PMID: 22112476    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), R Peto, +15 authors, K Pritchard.
Lancet, 2011 Dec 14; 379(9814). PMID: 22152853    Free PMC article.
Highly Cited.
Highly sensitive proximity mediated immunoassay reveals HER2 status conversion in the circulating tumor cells of metastatic breast cancer patients.
Phillip Kim, Xinjun Liu, +8 authors, Sharat Singh.
Proteome Sci, 2011 Dec 17; 9(1). PMID: 22172159    Free PMC article.
Early developments in gene-expression profiling of breast tumors: potential for increasing black-white patient disparities in breast cancer outcomes?
Donna H Odierna, Aimee Afable-Munsuz, +5 authors, Ninez A Ponce.
Per Med, 2011 Dec 23; 8(6). PMID: 22190978    Free PMC article.
Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).
Laura J Esserman, Donald A Berry, +32 authors, I-SPY 1 TRIAL Investigators.
Breast Cancer Res Treat, 2011 Dec 27; 132(3). PMID: 22198468    Free PMC article.
Highly Cited.
'Omic approaches to preventing or managing metastatic breast cancer.
Obi L Griffith, Joe W Gray.
Breast Cancer Res, 2012 Jan 06; 13(6). PMID: 22216753    Free PMC article.
Review.
Luminal-B breast cancer and novel therapeutic targets.
Ben Tran, Philippe L Bedard.
Breast Cancer Res, 2012 Jan 06; 13(6). PMID: 22217398    Free PMC article.
Review.
Gene expression profiling: changing face of breast cancer classification and management.
Robert Wesolowski, Bhuvaneswari Ramaswamy.
Gene Expr, 2012 Jan 25; 15(3). PMID: 22268293    Free PMC article.
Review.
Do we need biomarkers to predict the benefit of adding adjuvant taxanes for treatment of breast cancer?
José Pérez-García, Javier Cortés.
Breast Cancer Res, 2012 Feb 03; 14(1). PMID: 22297134    Free PMC article.
Assessing treatment-selection markers using a potential outcomes framework.
Ying Huang, Peter B Gilbert, Holly Janes.
Biometrics, 2012 Feb 04; 68(3). PMID: 22299708    Free PMC article.
Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers.
Sarah C Baumgarten, Jonna Frasor.
Mol Endocrinol, 2012 Feb 04; 26(3). PMID: 22301780    Free PMC article.
Review.
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Benjamin T Spike, Dannielle D Engle, +3 authors, Geoffrey M Wahl.
Cell Stem Cell, 2012 Feb 07; 10(2). PMID: 22305568    Free PMC article.
Highly Cited.
Detection of collagen triple helix repeat containing-1 and nuclear factor (erythroid-derived 2)-like 3 in colorectal cancer.
Marco Palma, Lissett Lopez, +7 authors, María-Jose Rodriguez.
BMC Clin Pathol, 2012 Feb 11; 12. PMID: 22321245    Free PMC article.
Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial.
Maggie C U Cheang, K David Voduc, +15 authors, Torsten O Nielsen.
Clin Cancer Res, 2012 Feb 22; 18(8). PMID: 22351696    Free PMC article.
A gene signature for predicting outcome in patients with basal-like breast cancer.
Robin M Hallett, Anna Dvorkin-Gheva, Anita Bane, John A Hassell.
Sci Rep, 2012 Feb 23; 2. PMID: 22355741    Free PMC article.
Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Mar 13; 6(2). PMID: 22406404    Free PMC article.
Review.
Agreement in risk prediction between the 21-gene recurrence score assay (Oncotype DX®) and the PAM50 breast cancer intrinsic Classifier™ in early-stage estrogen receptor-positive breast cancer.
Catherine M Kelly, Philip S Bernard, +7 authors, Lajos Pusztai.
Oncologist, 2012 Mar 16; 17(4). PMID: 22418568    Free PMC article.
Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer.
Stian Knappskog, Ranjan Chrisanthar, +8 authors, Per E Lønning.
Breast Cancer Res, 2012 Mar 17; 14(2). PMID: 22420423    Free PMC article.
Patients with positive axillary lymph nodes: how to use genomic assays.
Ruta Rao.
Curr Treat Options Oncol, 2012 Mar 20; 13(2). PMID: 22426945
Stakeholder assessment of the evidence for cancer genomic tests: insights from three case studies.
Patricia A Deverka, Sheri D Schully, +5 authors, Scott D Ramsey.
Genet Med, 2012 Apr 07; 14(7). PMID: 22481130    Free PMC article.
Perspectives on personalized cancer care.
Garrett M Dancika, Dan Theodorescu.
Urol Oncol, 2012 Apr 11; 30(2). PMID: 22489325    Free PMC article.
Assessment of the contribution of the IHC4+C score to decision making in clinical practice in early breast cancer.
S Barton, L Zabaglo, +6 authors, M Dowsett.
Br J Cancer, 2012 Apr 26; 106(11). PMID: 22531639    Free PMC article.
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy.
Robin M Hallett, Gregory Pond, John A Hassell.
BMC Med Genomics, 2012 May 15; 5. PMID: 22578285    Free PMC article.
Adoption of gene expression profile testing and association with use of chemotherapy among women with breast cancer.
Michael J Hassett, Samuel M Silver, +12 authors, Jane C Weeks.
J Clin Oncol, 2012 May 16; 30(18). PMID: 22585699    Free PMC article.
Poor-prognosis estrogen receptor- positive disease: present and future clinical solutions.
Per E Lønning.
Ther Adv Med Oncol, 2012 May 17; 4(3). PMID: 22590486    Free PMC article.
Quantitative in situ measurement of estrogen receptor mRNA predicts response to tamoxifen.
Jennifer M Bordeaux, Huan Cheng, +7 authors, David L Rimm.
PLoS One, 2012 May 19; 7(5). PMID: 22606272    Free PMC article.
Extended benefit from sequential administration of docetaxel after standard fluorouracil, epirubicin, and cyclophosphamide regimen for node-positive breast cancer: the 8-year follow-up results of the UNICANCER-PACS01 trial.
Bruno Coudert, Bernard Asselain, +18 authors, UNICANCER Breast Group.
Oncologist, 2012 May 23; 17(7). PMID: 22610153    Free PMC article.
Personal genomic testing as part of the complete breast cancer risk assessment: a case report.
Sara Riordan, David F Rodriguez, Shannon Kieran.
J Genet Couns, 2012 May 23; 21(5). PMID: 22610652
The implications of breast cancer molecular phenotype for radiation oncology.
Shirin Sioshansi, Kathryn E Huber, David E Wazer.
Front Oncol, 2011 Jan 01; 1. PMID: 22649753    Free PMC article.
Network-induced classification kernels for gene expression profile analysis.
Ofer Lavi, Gideon Dror, Ron Shamir.
J Comput Biol, 2012 Jun 16; 19(6). PMID: 22697242    Free PMC article.
TOP2A RNA expression and recurrence in estrogen receptor-positive breast cancer.
Joseph A Sparano, Lori J Goldstein, +2 authors, Robert Gray.
Breast Cancer Res Treat, 2012 Jun 19; 134(2). PMID: 22706628    Free PMC article.
Predicting the response to preoperative radiation or chemoradiation by a microarray analysis of the gene expression profiles in rectal cancer.
Takashi Akiyoshi, Takashi Kobunai, Toshiaki Watanabe.
Surg Today, 2012 Jun 19; 42(8). PMID: 22706722
Review.
A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen.
Stephen K Chia, Vivien H Bramwell, +12 authors, Torsten O Nielsen.
Clin Cancer Res, 2012 Jun 20; 18(16). PMID: 22711706    Free PMC article.
Highly Cited.
The influence of non-clinical patient factors on medical oncologists' decisions to recommend breast cancer adjuvant chemotherapy.
T May Pini, Sarah T Hawley, +2 authors, Jennifer J Griggs.
Breast Cancer Res Treat, 2012 Jun 22; 134(2). PMID: 22718307    Free PMC article.
Why does Oncotype DX recurrence score reduce adjuvant chemotherapy use?
Jeffrey G Schneider, Danny N Khalil.
Breast Cancer Res Treat, 2012 Jun 23; 134(3). PMID: 22723033    Free PMC article.
A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer.
Silvia Dellapasqua, Vincenzo Bagnardi, +9 authors, Marco Colleoni.
Breast, 2012 Jul 04; 21(5). PMID: 22749924    Free PMC article.
Association of sleep duration and breast cancer OncotypeDX recurrence score.
Cheryl L Thompson, Li Li.
Breast Cancer Res Treat, 2012 Jul 04; 134(3). PMID: 22752291    Free PMC article.
Signatures of tumor-immune interactions as biomarkers for breast cancer prognosis.
Masoud H Manjili, Kayvan Najarian, Xiang-Yang Wang.
Future Oncol, 2012 Jul 07; 8(6). PMID: 22764768    Free PMC article.
Review.
Whole transcriptome RNA-Seq analysis of breast cancer recurrence risk using formalin-fixed paraffin-embedded tumor tissue.
Dominick Sinicropi, Kunbin Qu, +14 authors, Joffre Baker.
PLoS One, 2012 Jul 19; 7(7). PMID: 22808097    Free PMC article.
High-risk estrogen-receptor-positive breast cancer: identification and implications for therapy.
Rosemary L Balleine, Nicholas R Wilcken.
Mol Diagn Ther, 2012 Jul 21; 16(4). PMID: 22812573
Review.
Distinct genes related to drug response identified in ER positive and ER negative breast cancer cell lines.
Kui Shen, Shara D Rice, +9 authors, Nan Song.
PLoS One, 2012 Jul 21; 7(7). PMID: 22815861    Free PMC article.
Understanding how breast cancer patients use risk information from genomic tests.
Jessica T DeFrank, Lisa A Carey, Noel T Brewer.
J Behav Med, 2012 Aug 11; 36(6). PMID: 22878783    Free PMC article.
The non-crosslinking fixative RCL2®-CS100 is compatible with both pathology diagnosis and molecular analyses.
Florence Boissière-Michot, Amélie Denouël, +5 authors, Frédéric Bibeau.
Pathol Oncol Res, 2012 Aug 16; 19(1). PMID: 22893391
Psychosocial and Quality of Life in Women Receiving the 21-Gene Recurrence Score Assay: The Impact of Decision Style in Women with Intermediate RS.
Nadiyah Sulayman, Elizabeth Spellman, +4 authors, Suzanne C O'Neill.
J Cancer Epidemiol, 2012 Aug 18; 2012. PMID: 22899924    Free PMC article.
What are we learning from the cancer genome?
Eric A Collisson, Raymond J Cho, Joe W Gray.
Nat Rev Clin Oncol, 2012 Sep 12; 9(11). PMID: 22965149    Free PMC article.
Review.
Cost-effectiveness of the 21-gene recurrence score assay in the context of multifactorial decision making to guide chemotherapy for early-stage breast cancer.
Shelby D Reed, Michaela A Dinan, Kevin A Schulman, Gary H Lyman.
Genet Med, 2012 Sep 15; 15(3). PMID: 22975761    Free PMC article.
Guidelines for locoregional therapy in primary breast cancer in developing countries: The results of an expert panel at the 8(th) Annual Women's Cancer Initiative - Tata Memorial Hospital (WCI-TMH) Conference.
Anusheel Munshi, Sudeep Gupta, +12 authors, other Locoregional Panel Members.
Indian J Med Paediatr Oncol, 2012 Sep 19; 33(2). PMID: 22988354    Free PMC article.
Ki-67 as a prognostic marker according to breast cancer subtype and a predictor of recurrence time in primary breast cancer.
Reiki Nishimura, Tomofumi Osako, +3 authors, Nobuyuki Arima.
Exp Ther Med, 2010 Sep 01; 1(5). PMID: 22993598    Free PMC article.
A multichannel Markov random field framework for tumor segmentation with an application to classification of gene expression-based breast cancer recurrence risk.
Ahmed B Ashraf, Sara C Gavenonis, +3 authors, Despina Kontos.
IEEE Trans Med Imaging, 2012 Sep 26; 32(4). PMID: 23008246    Free PMC article.
Study designs and statistical analyses for biomarker research.
Masahiko Gosho, Kengo Nagashima, Yasunori Sato.
Sensors (Basel), 2012 Sep 27; 12(7). PMID: 23012528    Free PMC article.
Review.
Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node negative breast cancer.
Malek B Hannouf, Bin Xie, Muriel Brackstone, Gregory S Zaric.
BMC Cancer, 2012 Oct 04; 12. PMID: 23031196    Free PMC article.
Molecular alterations associated with breast cancer mortality.
Laura M Voeghtly, Kim Mamula, +2 authors, Rachel E Ellsworth.
PLoS One, 2012 Oct 12; 7(10). PMID: 23056464    Free PMC article.
Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis.
Medical Advisory Secretariat.
Ont Health Technol Assess Ser, 2010 Jan 01; 10(23). PMID: 23074401    Free PMC article.
Personalized medicine in breast cancer: a systematic review.
Sang-Hoon Cho, Jongsu Jeon, Seung Il Kim.
J Breast Cancer, 2012 Oct 24; 15(3). PMID: 23091538    Free PMC article.
The 21-gene recurrence score assay impacts adjuvant therapy recommendations for ER-positive, node-negative and node-positive early breast cancer resulting in a risk-adapted change in chemotherapy use.
W Eiermann, M Rezai, +13 authors, J Blohmer.
Ann Oncol, 2012 Nov 09; 24(3). PMID: 23136233    Free PMC article.
Evaluating the efficacy of current clinical practice of adjuvant chemotherapy in postmenopausal women with early-stage, estrogen or progesterone receptor-positive, one-to-three positive axillary lymph node, breast cancer.
M B Hannouf, M Brackstone, B Xie, G S Zaric.
Curr Oncol, 2012 Nov 13; 19(5). PMID: 23144580    Free PMC article.
Accelerated partial breast irradiation for early-stage breast cancer: controversies and current indications for use.
Lisa C Klepczyk, Kimberly S Keene, Jennifer F De Los Santos.
Curr Treat Options Oncol, 2012 Nov 28; 14(1). PMID: 23179757
Review.
Barriers to the use of personalized medicine in breast cancer.
Christine B Weldon, Julia R Trosman, +2 authors, Julian C Schink.
J Oncol Pract, 2012 Nov 28; 8(4). PMID: 23180995    Free PMC article.
Predictors of margin status after breast-conserving operations in an underscreened population.
Rozbeh Torabi, Chiu-Hsieh Hsu, +3 authors, Ian K Komenaka.
Langenbecks Arch Surg, 2012 Nov 28; 398(3). PMID: 23184267
Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze.
EPMA J, 2010 Sep 01; 1(3). PMID: 23199086    Free PMC article.
The front line of genomic translation.
Suzanne C O'Neill, Colleen M McBride, +2 authors, Louise Wideroff.
J Cancer Epidemiol, 2012 Dec 05; 2012. PMID: 23209467    Free PMC article.
Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.
Aleix Prat, Maggie Chon U Cheang, +8 authors, Charles M Perou.
J Clin Oncol, 2012 Dec 13; 31(2). PMID: 23233704    Free PMC article.
Highly Cited.
Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium.
Claudia Schurmann, Katharina Heim, +28 authors, Andreas Ziegler.
PLoS One, 2012 Dec 14; 7(12). PMID: 23236413    Free PMC article.
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
Francesco Niola, Xudong Zhao, +13 authors, Anna Lasorella.
J Clin Invest, 2012 Dec 18; 123(1). PMID: 23241957    Free PMC article.
Positive expression of Lin28 is correlated with poor survival in gastric carcinoma.
Chaoyang Xu, Jiangguo Shen, +3 authors, Linbo Wang.
Med Oncol, 2013 Jan 08; 30(1). PMID: 23292830
Optimizing surgical margins in breast conservation.
Preya Ananthakrishnan, Fatih Levent Balci, Joseph P Crowe.
Int J Surg Oncol, 2013 Jan 11; 2012. PMID: 23304479    Free PMC article.
The genomic landscape of breast cancer as a therapeutic roadmap.
Matthew J Ellis, Charles M Perou.
Cancer Discov, 2013 Jan 16; 3(1). PMID: 23319768    Free PMC article.
Highly Cited.
Gene signatures in breast cancer: current and future uses.
Enrique Espinosa Arranz, Juan Ángel Fresno Vara, Angelo Gámez-Pozo, Pilar Zamora.
Transl Oncol, 2013 Jan 17; 5(6). PMID: 23323153    Free PMC article.
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
H A Azim, S Michiels, +9 authors, C Swanton.
Ann Oncol, 2013 Jan 23; 24(3). PMID: 23337633    Free PMC article.
Citizens' perspectives on personalized medicine: a qualitative public deliberation study.
Yvonne Bombard, Julia Abelson, Dorina Simeonov, Francois-Pierre Gauvin.
Eur J Hum Genet, 2013 Jan 24; 21(11). PMID: 23340511    Free PMC article.
Significance analysis of prognostic signatures.
Andrew H Beck, Nicholas W Knoblauch, +7 authors, Benjamin Haibe-Kains.
PLoS Comput Biol, 2013 Feb 01; 9(1). PMID: 23365551    Free PMC article.
Translating metastasis-related biomarkers to the clinic--progress and pitfalls.
François-Clément Bidard, Jean-Yves Pierga, Jean-Charles Soria, Jean Paul Thiery.
Nat Rev Clin Oncol, 2013 Feb 06; 10(3). PMID: 23381003
Review.
A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer.
Takayuki Kobayashi, Keiichi Iwaya, +4 authors, Osamu Matsubara.
BMC Clin Pathol, 2013 Feb 07; 13. PMID: 23384409    Free PMC article.
Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?
Olga Golubnitschaja, Kristina Yeghiazaryan, +5 authors, Hans H Schild.
EPMA J, 2013 Feb 20; 4(1). PMID: 23418957    Free PMC article.
PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer.
Miguel Martín, Aleix Prat, +24 authors, Philip S Bernard.
Breast Cancer Res Treat, 2013 Feb 21; 138(2). PMID: 23423445    Free PMC article.
Prognostic value of proliferation markers expression in breast cancer.
Natalija Dedić Plavetić, Jasminka Jakić-Razumović, Ana Kulić, Damir Vrbanec.
Med Oncol, 2013 Mar 08; 30(2). PMID: 23468220
Prediction of the Oncotype DX recurrence score: use of pathology-generated equations derived by linear regression analysis.
Molly E Klein, David J Dabbs, +4 authors, Rohit Bhargava.
Mod Pathol, 2013 Mar 19; 26(5). PMID: 23503643    Free PMC article.
Comparison of EndoPredict and Oncotype DX test results in hormone receptor positive invasive breast cancer.
Zsuzsanna Varga, Peter Sinn, +6 authors, Holger Moch.
PLoS One, 2013 Mar 19; 8(3). PMID: 23505515    Free PMC article.
Biomarkers and sustainable innovation in cardiovascular drug development: lessons from near and far afield.
Russell M Medford, T Forcht Dagi, Robert S Rosenson, Margaret K Offermann.
Curr Atheroscler Rep, 2013 Mar 21; 15(5). PMID: 23512605
Review.
Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581.
Alan P Venook, Donna Niedzwiecki, +12 authors, Monica M Bertagnolli.
J Clin Oncol, 2013 Mar 27; 31(14). PMID: 23530100    Free PMC article.
Development of a multi-biomarker disease activity test for rheumatoid arthritis.
Michael Centola, Guy Cavet, +14 authors, Jeffrey R Curtis.
PLoS One, 2013 Apr 16; 8(4). PMID: 23585841    Free PMC article.
Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.
Srikanth Nagalla, Jeff W Chou, +9 authors, Lance D Miller.
Genome Biol, 2013 Apr 27; 14(4). PMID: 23618380    Free PMC article.
Highly Cited.
Identification and validation of a new set of five genes for prediction of risk in early breast cancer.
Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi.
Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477    Free PMC article.
A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the U.K.
S Holt, G Bertelli, +12 authors, C J Phillips.
Br J Cancer, 2013 May 23; 108(11). PMID: 23695023    Free PMC article.
Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses.
Roman Rouzier, Paolo Pronzato, +3 authors, William J Valentine.
Breast Cancer Res Treat, 2013 Jun 01; 139(3). PMID: 23722312    Free PMC article.
Systematic Review.
Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response.
Rinath M Jeselsohn, Lillian Werner, +11 authors, Steven E Come.
PLoS One, 2013 Jun 07; 8(5). PMID: 23741308    Free PMC article.
In vitro effects of herbicides and insecticides on human breast cells.
Jessica D Rich, Seth M Gabriel, Jennifer R Schultz-Norton.
ISRN Toxicol, 2012 Jan 01; 2012. PMID: 23762632    Free PMC article.
Optimal targeting of HER2-PI3K signaling in breast cancer: mechanistic insights and clinical implications.
Brent N Rexer, Carlos L Arteaga.
Cancer Res, 2013 Jun 25; 73(13). PMID: 23794708    Free PMC article.
Review.
The impact of the 21-gene Recurrence Score assay on clinical decision-making in node-positive (up to 3 positive nodes) estrogen receptor-positive breast cancer patients.
Salomon M Stemmer, Shmuel H Klang, +7 authors, Nicky Lieberman.
Breast Cancer Res Treat, 2013 Jun 27; 140(1). PMID: 23801158    Free PMC article.
A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer.
Amanda Eustace, Navin Mani, +12 authors, Catharine M L West.
Clin Cancer Res, 2013 Jul 04; 19(17). PMID: 23820108    Free PMC article.
Cellular iron metabolism in prognosis and therapy of breast cancer.
Suzy V Torti, Frank M Torti.
Crit Rev Oncog, 2013 Jul 25; 18(5). PMID: 23879588    Free PMC article.
Review.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Review.
Who gets genomic testing for breast cancer recurrence risk?
J T DeFrank, T Salz, K Reeder-Hayes, N T Brewer.
Public Health Genomics, 2013 Aug 01; 16(5). PMID: 23899493    Free PMC article.
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
A Goldhirsch, E P Winer, +5 authors, Panel members.
Ann Oncol, 2013 Aug 07; 24(9). PMID: 23917950    Free PMC article.
Highly Cited.
Evaluating use characteristics for the oncotype dx 21-gene recurrence score and concordance with chemotherapy use in early-stage breast cancer.
Clara Chen, Rahul Dhanda, +2 authors, Debra A Patt.
J Oncol Pract, 2013 Aug 15; 9(4). PMID: 23942918    Free PMC article.
Preoperative core needle biopsy is accurate in determining molecular subtypes in invasive breast cancer.
Xiaosong Chen, Long Sun, +10 authors, Kunwei Shen.
BMC Cancer, 2013 Aug 21; 13. PMID: 23957561    Free PMC article.
The impact of the Oncotype Dx breast cancer assay in clinical practice: a systematic review and meta-analysis.
Josh J Carlson, Joshua A Roth.
Breast Cancer Res Treat, 2013 Aug 27; 141(1). PMID: 23974828    Free PMC article.
Highly Cited. Systematic Review.
Effectiveness and complications of anthracycline and taxane in the therapy of breast cancer: a meta-analysis.
Qing-jing Feng, Feng Zhang, Xiao-yun Huang, Zhi-xiang Wu.
Pathol Oncol Res, 2013 Aug 28; 20(1). PMID: 23980023
Genomic Grade Index (GGI): feasibility in routine practice and impact on treatment decisions in early breast cancer.
Otto Metzger-Filho, Aurélie Catteau, +21 authors, Christos Sotiriou.
PLoS One, 2013 Aug 31; 8(8). PMID: 23990869    Free PMC article.
Effect of chemotherapy for luminal a breast cancer.
Naotaka Uchida, Takako Suda, Kiyosuke Ishiguro.
Yonago Acta Med, 2013 Sep 14; 56(2). PMID: 24031152    Free PMC article.
The molecular diversity of Luminal A breast tumors.
Giovanni Ciriello, Rileen Sinha, +5 authors, Nikolaus Schultz.
Breast Cancer Res Treat, 2013 Oct 08; 141(3). PMID: 24096568    Free PMC article.
Evaluating the 21-gene assay Recurrence Score® as a predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast cancer.
Takayuki Ueno, Norikazu Masuda, +12 authors, Masakazu Toi.
Int J Clin Oncol, 2013 Oct 09; 19(4). PMID: 24101215
Analytical validation of the Oncotype DX prostate cancer assay - a clinical RT-PCR assay optimized for prostate needle biopsies.
Dejan Knezevic, Audrey D Goddard, +8 authors, Christopher Quale.
BMC Genomics, 2013 Oct 10; 14. PMID: 24103217    Free PMC article.
Highly Cited.
p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors.
Mitsugu Yamamoto, Mitsuchika Hosoda, +6 authors, Hiroko Yamashita.
Cancer Sci, 2013 Oct 15; 105(1). PMID: 24118529    Free PMC article.
Molecular profiling for breast cancer: a comprehensive review.
Muaiad Kittaneh, Alberto J Montero, Stefan Glück.
Biomark Cancer, 2013 Nov 20; 5. PMID: 24250234    Free PMC article.
Review.
Towards the integration, annotation and association of historical microarray experiments with RNA-seq.
Shweta S Chavan, Michael A Bauer, +2 authors, Donald J Johann.
BMC Bioinformatics, 2013 Dec 07; 14 Suppl 14. PMID: 24268045    Free PMC article.
Biomarker enrichment strategies: matching trial design to biomarker credentials.
Boris Freidlin, Edward L Korn.
Nat Rev Clin Oncol, 2013 Nov 28; 11(2). PMID: 24281059
Review.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Suzanne A Eccles, Eric O Aboagye, +84 authors, Alastair M Thompson.
Breast Cancer Res, 2013 Nov 30; 15(5). PMID: 24286369    Free PMC article.
Highly Cited. Review.
Cost effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in post-menopausal women with early-stage estrogen or progesterone-receptor-positive, axillary lymph-node positive breast cancer.
Malek B Hannouf, Bin Xie, Muriel Brackstone, Gregory S Zaric.
Pharmacoeconomics, 2013 Nov 30; 32(2). PMID: 24288208
Metastasis dormancy in estrogen receptor-positive breast cancer.
Xiang H-F Zhang, Mario Giuliano, +2 authors, C Kent Osborne.
Clin Cancer Res, 2013 Dec 04; 19(23). PMID: 24298069    Free PMC article.
Highly Cited. Review.
Prognostic discrimination using a 70-gene signature among patients with estrogen receptor-positive breast cancer and an intermediate 21-gene recurrence score.
Sung Gwe Ahn, Hak Min Lee, +5 authors, In-Sun Chu.
Int J Mol Sci, 2013 Dec 07; 14(12). PMID: 24304542    Free PMC article.
Novel functional assay for spindle-assembly checkpoint by cyclin-dependent kinase activity to predict taxane chemosensitivity in breast tumor patient.
Yasuhiro Torikoshi, Keigo Gohda, +11 authors, Naoto T Ueno.
J Cancer, 2013 Dec 07; 4(9). PMID: 24312139    Free PMC article.
A machine learned classifier that uses gene expression data to accurately predict estrogen receptor status.
Meysam Bastani, Larissa Vos, +4 authors, Russell Greiner.
PLoS One, 2013 Dec 07; 8(12). PMID: 24312637    Free PMC article.
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.
Jacob J Kennedy, Susan E Abbatiello, +18 authors, Amanda G Paulovich.
Nat Methods, 2013 Dec 10; 11(2). PMID: 24317253    Free PMC article.
Highly Cited.
Sex hormone receptor repertoire in breast cancer.
Gerald M Higa, Ryan G Fell.
Int J Breast Cancer, 2013 Dec 11; 2013. PMID: 24324894    Free PMC article.
Review.
Clinical utility of the combination of lapatinib and letrozole in the management of hormone receptor-positive and HER2-positive advanced breast cancer.
Priscilla Merriam, William M Sikov.
Breast Cancer (Dove Med Press), 2011 Jan 01; 3. PMID: 24367183    Free PMC article.
Review.
Differential prognostic indicators for locoregional recurrence, distant recurrence, and death of breast cancer.
Rungnapa Chairat, Adisorn Puttisri, +3 authors, Jayanton Patumanond.
ISRN Oncol, 2014 Jan 01; 2013. PMID: 24377049    Free PMC article.
The impact of the Oncotype DX Recurrence Score on treatment decisions and clinical outcomes in patients with early breast cancer: the Maccabi Healthcare Services experience with a unified testing policy.
Nava Siegelmann-Danieli, Barbara Silverman, +3 authors, Avi Porath.
Ecancermedicalscience, 2014 Jan 05; 7. PMID: 24386009    Free PMC article.
Tamoxifen versus tamoxifen plus doxorubicin and cyclophosphamide as adjuvant therapy for node-positive postmenopausal breast cancer: results of a Japan Clinical Oncology Group Study (JCOG9401).
Tadahiko Shien, Hiroji Iwata, +7 authors, Haruhiko Fukuda.
Int J Clin Oncol, 2014 Jan 08; 19(6). PMID: 24395447
Neoadjuvant Hormonal Therapy is Associated with Comparable Outcomes to Neoadjuvant Chemotherapy in Post-Menopausal Women with Estrogen Receptor-Positive Breast Cancer.
David M Marcus, Jeffrey M Switchenko, +5 authors, Mylin A Torres.
Front Oncol, 2014 Jan 11; 3. PMID: 24409418    Free PMC article.
AGO Recommendations for Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2013.
Anton Scharl, Christoph Thomssen, Nadia Harbeck, Volkmar Müller.
Breast Care (Basel), 2014 Jan 15; 8(3). PMID: 24415966    Free PMC article.
Breast Cancer Biomarkers: Utility in Clinical Practice.
Fanny Le Du, Naoto T Ueno, Ana M Gonzalez-Angulo.
Curr Breast Cancer Rep, 2014 Jan 15; 5(4). PMID: 24416469    Free PMC article.
Reply to E.J. Moylan et al.
Sandra M Swain, Gong Tang, Charles E Geyer.
J Clin Oncol, 2014 Jan 15; 32(6). PMID: 24419136    Free PMC article.
The application of Oncotype DX in early-stage lymph-node-positive disease.
Sarika Jain, William J Gradishar.
Curr Oncol Rep, 2014 Jan 21; 16(1). PMID: 24442572
Review.
Timing of determining axillary lymph node status when neoadjuvant chemotherapy is used.
Eleftherios P Mamounas.
Curr Oncol Rep, 2014 Jan 22; 16(2). PMID: 24445496    Free PMC article.
Review.
Long-term impact of the 70-gene signature on breast cancer outcome.
C A Drukker, H van Tinteren, +4 authors, L J Van't Veer.
Breast Cancer Res Treat, 2014 Jan 22; 143(3). PMID: 24445566    Free PMC article.
Oncotype dx results in multiple primary breast cancers.
Michael J Toole, Kelley M Kidwell, Catherine Van Poznak.
Breast Cancer (Auckl), 2014 Jan 24; 8. PMID: 24453493    Free PMC article.
Reply to: prediction of benefit from chemotherapy in ER-positive/HER2-negative breast cancer.
A Goldhirsch, A S Coates.
Ann Oncol, 2014 Jan 25; 25(3). PMID: 24458471    Free PMC article.
Cost-effectiveness analysis of Mammostrat® compared with Oncotype DX® to inform the treatment of breast cancer.
Kimberly Mislick, Warren Schonfeld, Carolyn Bodnar, Kuo Bianchini Tong.
Clinicoecon Outcomes Res, 2014 Jan 29; 6. PMID: 24470765    Free PMC article.
Integrative gene network construction to analyze cancer recurrence using semi-supervised learning.
Chihyun Park, Jaegyoon Ahn, Hyunjin Kim, Sanghyun Park.
PLoS One, 2014 Feb 06; 9(1). PMID: 24497942    Free PMC article.
Breast tumor subgroups reveal diverse clinical prognostic power.
Zhaoqi Liu, Xiang-Sun Zhang, Shihua Zhang.
Sci Rep, 2014 Feb 07; 4. PMID: 24499868    Free PMC article.
Prediction of benefit from chemotherapy in ER-positive/HER2-negative breast cancer--a problem still to be solved.
M Schmidt, M Untch.
Ann Oncol, 2014 Feb 07; 25(3). PMID: 24500980    Free PMC article.
Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes.
Bette J Caan, Carol Sweeney, +8 authors, Philip S Bernard.
Cancer Epidemiol Biomarkers Prev, 2014 Feb 14; 23(5). PMID: 24521998    Free PMC article.
Genomic profiling in luminal breast cancer.
Oleg Gluz, Daniel Hofmann, +3 authors, Nadia Harbeck.
Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550749    Free PMC article.
Review.
Which threshold for ER positivity? a retrospective study based on 9639 patients.
M Yi, L Huo, +11 authors, K K Hunt.
Ann Oncol, 2014 Feb 25; 25(5). PMID: 24562447    Free PMC article.
Treatment decisions in estrogen receptor-positive early breast cancer patients with intermediate oncotype DX recurrence score results.
Georgeta Fried, Mor Moskovitz.
Springerplus, 2014 Feb 26; 3. PMID: 24567880    Free PMC article.
Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer.
Kristin Jonsdottir, Jörg Assmus, +4 authors, Emiel A M Janssen.
PLoS One, 2014 Mar 07; 9(3). PMID: 24599057    Free PMC article.
Collagen gel droplet-embedded culture-drug sensitivity test and Ki67 expression in estrogen receptor-positive and HER2-negative breast cancer.
Katsunori Tozuka, Jun Horiguchi, +7 authors, Izumi Takeyoshi.
Mol Clin Oncol, 2013 Jan 01; 1(1). PMID: 24649129    Free PMC article.
Evaluation and correlation of risk recurrence in early breast cancer assessed by Oncotype DX®, clinicopathological markers and tumor cell dissemination in the blood and bone marrow.
Bahriye Aktas, Agnes Bankfalvi, +2 authors, Sabine Kasimir-Bauer.
Mol Clin Oncol, 2014 Mar 22; 1(6). PMID: 24649291    Free PMC article.
Adaptive designs for clinical trials assessing biomarker-guided treatment strategies.
J Wason, A Marshall, +2 authors, N Stallard.
Br J Cancer, 2014 Mar 29; 110(8). PMID: 24667651    Free PMC article.
An approach to evaluating and comparing biomarkers for patient treatment selection.
Holly Janes, Marshall D Brown, Ying Huang, Margaret S Pepe.
Int J Biostat, 2014 Apr 04; 10(1). PMID: 24695044    Free PMC article.
Identification of intrinsic imaging phenotypes for breast cancer tumors: preliminary associations with gene expression profiles.
Ahmed Bilal Ashraf, Dania Daye, +4 authors, Despina Kontos.
Radiology, 2014 Apr 08; 272(2). PMID: 24702725    Free PMC article.
Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance.
Charlotte K Y Ng, Britta Weigelt, +5 authors, Jorge S Reis-Filho.
Cancer Res, 2014 Apr 08; 74(11). PMID: 24706696    Free PMC article.
Cost-effectiveness of a 14-gene risk score assay to target adjuvant chemotherapy in early stage non-squamous non-small cell lung cancer.
Joshua A Roth, Paul Billings, +2 authors, Josh J Carlson.
Oncologist, 2014 Apr 09; 19(5). PMID: 24710309    Free PMC article.
Clinical validation of the EndoPredict test in node-positive, chemotherapy-treated ER+/HER2- breast cancer patients: results from the GEICAM 9906 trial.
Miguel Martin, Jan C Brase, +15 authors, Alvaro Rodriguez-Lescure.
Breast Cancer Res, 2014 Apr 15; 16(2). PMID: 24725534    Free PMC article.
Interdisciplinary GoR level III Guidelines for the Diagnosis, Therapy and Follow-up Care of Breast Cancer: Short version - AWMF Registry No.: 032-045OL AWMF-Register-Nummer: 032-045OL - Kurzversion 3.0, Juli 2012.
R Kreienberg, U-S Albert, +3 authors, A Wöckel.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(6). PMID: 24771925    Free PMC article.
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility.
P Sinn, S Aulmann, +6 authors, A Schneeweiss.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(9). PMID: 24771945    Free PMC article.
Future directions for the early detection of recurrent breast cancer.
Erika J Schneble, Lindsey J Graham, +10 authors, Robert F Setlik.
J Cancer, 2014 May 03; 5(4). PMID: 24790657    Free PMC article.
Review.
Addressing overdiagnosis and overtreatment in cancer: a prescription for change.
Laura J Esserman, Ian M Thompson, +10 authors, Sudhir Srivastava.
Lancet Oncol, 2014 May 09; 15(6). PMID: 24807866    Free PMC article.
Highly Cited.
A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,2.
Shuang Zhao, S Laura Chang, +2 authors, Gary D Luker.
Transl Oncol, 2014 May 20;. PMID: 24836649    Free PMC article.
Predictive and prognostic value of the 21-gene recurrence score in hormone receptor-positive, node-positive breast cancer.
Adam M Brufsky.
Am J Clin Oncol, 2014 May 24; 37(4). PMID: 24853663    Free PMC article.
Systematic Review.
Relationship between chemotherapy and prognosis in different subtypes of node-negative breast cancer.
Xia Liu, Yong Guan, +5 authors, Yun Niu.
Tumour Biol, 2014 May 28; 35(9). PMID: 24863944
Current status of gene expression profiling to assist decision making in stage II colon cancer.
Cheng E Chee, Neal J Meropol.
Oncologist, 2014 May 30; 19(7). PMID: 24869929    Free PMC article.
From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.
Chiara Fabbri, Stefano Porcelli, Alessandro Serretti.
Can J Psychiatry, 2014 Jun 03; 59(2). PMID: 24881125    Free PMC article.
Review.
Past, present, and future challenges in breast cancer treatment.
George W Sledge, Eleftherios P Mamounas, +3 authors, Antonio C Wolff.
J Clin Oncol, 2014 Jun 04; 32(19). PMID: 24888802    Free PMC article.
Outcomes by tumor subtype and treatment pattern in women with small, node-negative breast cancer: a multi-institutional study.
Ines Vaz-Luis, Rebecca A Ottesen, +10 authors, Nancy U Lin.
J Clin Oncol, 2014 Jun 04; 32(20). PMID: 24888816    Free PMC article.
Combining biomarkers to optimize patient treatment recommendations.
Chaeryon Kang, Holly Janes, Ying Huang.
Biometrics, 2014 Jun 04; 70(3). PMID: 24889663    Free PMC article.
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.
Thomas E Rohan, Xiaonan Xue, +10 authors, Joan G Jones.
J Natl Cancer Inst, 2014 Jun 05; 106(8). PMID: 24895374    Free PMC article.
Highly Cited.
A 41-gene signature derived from breast cancer stem cells as a predictor of survival.
Zhi-Qiang Yin, Jian-Jun Liu, +9 authors, Hong-Xia Wang.
J Exp Clin Cancer Res, 2014 Jun 08; 33. PMID: 24906694    Free PMC article.
Modern Risk Assessment for Individualizing Treatment Concepts in Early-stage Breast Cancer.
Alex Farr, Rachel Wuerstlein, +2 authors, Nadia Harbeck.
Rev Obstet Gynecol, 2013 Jan 01; 6(3-4). PMID: 24920978    Free PMC article.
Access to personalized medicine: factors influencing the use and value of gene expression profiling in breast cancer treatment.
Y Bombard, L Rozmovits, +3 authors, D A Marshall.
Curr Oncol, 2014 Jun 19; 21(3). PMID: 24940102    Free PMC article.
How does genome sequencing impact surgery?
Marlies S Reimers, Charla C Engels, +2 authors, Gerrit J Liefers.
Nat Rev Clin Oncol, 2014 Jun 25; 11(10). PMID: 24958181
Review.
In situ quantitative measurement of HER2mRNA predicts benefit from trastuzumab-containing chemotherapy in a cohort of metastatic breast cancer patients.
Maria Vassilakopoulou, Taiwo Togun, +11 authors, Amanda Psyrri.
PLoS One, 2014 Jun 27; 9(6). PMID: 24968015    Free PMC article.
Co-development of diagnostic vectors to support targeted therapies and theranostics: essential tools in personalized cancer therapy.
Nicholas C Nicolaides, Daniel J O'Shannessy, Earl Albone, Luigi Grasso.
Front Oncol, 2014 Jul 02; 4. PMID: 24982846    Free PMC article.
Review.
Systematically defining single-gene determinants of response to neoadjuvant chemotherapy reveals specific biomarkers.
Agnieszka K Witkiewicz, Uthra Balaji, Erik S Knudsen.
Clin Cancer Res, 2014 Jul 23; 20(18). PMID: 25047707    Free PMC article.
Diagnostic tests based on gene expression profile in breast cancer: from background to clinical use.
Laura Zanotti, Alberto Bottini, +2 authors, Maria Rosa Cappelletti.
Tumour Biol, 2014 Jul 23; 35(9). PMID: 25048969
Review.
Evaluation of the ability of adjuvant tamoxifen-benefit gene signatures to predict outcome of hormone-naive estrogen receptor-positive breast cancer patients treated with tamoxifen in the advanced setting.
Anieta M Sieuwerts, Maria B Lyng, +6 authors, Henrik J Ditzel.
Mol Oncol, 2014 Aug 02; 8(8). PMID: 25081647    Free PMC article.
How transferable are recommendations of the era of treating conventionally defined breast cancer for the era of molecularly characterised breast cancer?
Robert Königsberg, Christian Dittrich.
Gland Surg, 2012 Nov 01; 1(3). PMID: 25083440    Free PMC article.
Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer.
Qinchuan Wang, Jichun Zhou, +10 authors, Linbo Wang.
Tumour Biol, 2014 Aug 17; 35(11). PMID: 25128063
Age-specific changes in intrinsic breast cancer subtypes: a focus on older women.
Emily O Jenkins, Allison M Deal, +4 authors, Hyman B Muss.
Oncologist, 2014 Aug 22; 19(10). PMID: 25142841    Free PMC article.
Testing the predictive value of peripheral gene expression for nonremission following citalopram treatment for major depression.
Jean-Philippe Guilloux, Sabrina Bassi, +5 authors, Etienne Sibille.
Neuropsychopharmacology, 2014 Sep 02; 40(3). PMID: 25176167    Free PMC article.
Chemotherapy in early breast cancer: when, how and which one?
Marcus Schmidt.
Breast Care (Basel), 2014 Sep 02; 9(3). PMID: 25177256    Free PMC article.
Review.
Genome-based risk prediction for early stage breast cancer.
Christina Adaniel, Komal Jhaveri, Adriana Heguy, Francisco J Esteva.
Oncologist, 2014 Sep 05; 19(10). PMID: 25187476    Free PMC article.
Review.
Societal cost-effectiveness analysis of the 21-gene assay in estrogen-receptor-positive, lymph-node-negative early-stage breast cancer in Japan.
Hideko Yamauchi, Chizuko Nakagawa, +9 authors, Seigo Nakamura.
BMC Health Serv Res, 2014 Sep 06; 14. PMID: 25190451    Free PMC article.
The impact of Oncotype DX testing on breast cancer management and chemotherapy prescribing patterns in a tertiary referral centre.
Terri Patricia McVeigh, Lauren M Hughes, +4 authors, Michael J Kerin.
Eur J Cancer, 2014 Sep 23; 50(16). PMID: 25240289    Free PMC article.
Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer.
Kevin Kalinsky, Emerson A Lim, +10 authors, Dawn L Hershman.
Cancer Invest, 2014 Sep 26; 32(9). PMID: 25254601    Free PMC article.
Words matter: distinguishing "personalized medicine" and "biologically personalized therapeutics".
Nathan I Cherny, Elisabeth G E de Vries, +7 authors, Chariklia Tziraki.
J Natl Cancer Inst, 2014 Oct 09; 106(12). PMID: 25293984    Free PMC article.
Breast cancer therapy planning - a novel support concept for a sequential decision making problem.
Alexander Scherrer, Ilka Schwidde, +3 authors, Karl-Heinz Küfer.
Health Care Manag Sci, 2014 Oct 16; 18(3). PMID: 25315184
Prognostic relevance of biological subtype overrides that of TNM staging in breast cancer: discordance between stage and biology.
Hyun Ae Jung, Yeon Hee Park, +10 authors, Young-Hyuck Im.
Tumour Biol, 2014 Oct 20; 36(2). PMID: 25326808
Update on adjuvant chemotherapy for early breast cancer.
Murtuza M Rampurwala, Gabrielle B Rocque, Mark E Burkard.
Breast Cancer (Auckl), 2014 Oct 23; 8. PMID: 25336961    Free PMC article.
Review.
The clinical impact of 21-gene recurrence score on treatment decisions for patients with hormone receptor-positive early breast cancer in Korea.
Moo Hyun Lee, Wonshik Han, +7 authors, Eun Sook Lee.
Cancer Res Treat, 2014 Nov 11; 47(2). PMID: 25381828    Free PMC article.
Prediction of individual response to anticancer therapy: historical and future perspectives.
Florian T Unger, Irene Witte, Kerstin A David.
Cell Mol Life Sci, 2014 Nov 13; 72(4). PMID: 25387856    Free PMC article.
Review.
Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study.
D Balmativola, C Marchiò, +26 authors, A Sapino.
Breast Cancer Res Treat, 2014 Nov 15; 148(3). PMID: 25395316    Free PMC article.
Current treatment of early breast cancer: adjuvant and neoadjuvant therapy.
Elizabeth Miller, Hee Jin Lee, +3 authors, Bora Lim.
F1000Res, 2014 Nov 18; 3. PMID: 25400908    Free PMC article.
Review.
Cost-effectiveness analysis of prognostic gene expression signature-based stratification of early breast cancer patients.
Patricia R Blank, Martin Filipits, +11 authors, Michael Gnant.
Pharmacoeconomics, 2014 Nov 19; 33(2). PMID: 25404424    Free PMC article.
SWOG S0221: a phase III trial comparing chemotherapy schedules in high-risk early-stage breast cancer.
George T Budd, William E Barlow, +17 authors, Gabriel N Hortobagyi.
J Clin Oncol, 2014 Nov 26; 33(1). PMID: 25422488    Free PMC article.
The 21-gene recurrence score and locoregional recurrence in breast cancer patients.
Naresh K Jegadeesh, Sunjin Kim, +7 authors, Mylin A Torres.
Ann Surg Oncol, 2014 Dec 05; 22(4). PMID: 25472643    Free PMC article.
Clinical utility of gene-expression profiling in women with early breast cancer: an overview of systematic reviews.
Michael Marrone, Alison Stewart, W David Dotson.
Genet Med, 2014 Dec 05; 17(7). PMID: 25474343    Free PMC article.
Review.
The value of multigene predictors of clinical outcome in breast cancer: an analysis of the evidence.
Amalia M Issa, Vivek S Chaudhari, Gary E Marchant.
Expert Rev Mol Diagn, 2014 Dec 06; 15(2). PMID: 25479414    Free PMC article.
Review.
Emerging gene-based prognostic tools in early breast cancer: First steps to personalised medicine.
Umar Wazir, Kefah Mokbel.
World J Clin Oncol, 2014 Dec 11; 5(5). PMID: 25493218    Free PMC article.
Role of urokinase plasminogen activator and plasminogen activator inhibitor mRNA expression as prognostic factors in molecular subtypes of breast cancer.
Isabell Witzel, Karin Milde-Langosch, +8 authors, Volkmar Müller.
Onco Targets Ther, 2014 Dec 17; 7. PMID: 25506225    Free PMC article.
A guide for clinicians in the evaluation of emerging molecular diagnostics for newly diagnosed prostate cancer.
Steven E Canfield, Adam S Kibel, +3 authors, Judd W Moul.
Rev Urol, 2014 Dec 31; 16(4). PMID: 25548544    Free PMC article.
Clinical utility of gene expression profiling data for clinical decision-making regarding adjuvant therapy in early stage, node-negative breast cancer: a case report.
Steven R Schuster, Barbara A Pockaj, +2 authors, Donald W Northfelt.
J Pers Med, 2012 Jan 01; 2(3). PMID: 25562201    Free PMC article.
Understanding the economic value of molecular diagnostic tests: case studies and lessons learned.
Adrian Towse, Diego Ossa, +2 authors, Louis Garrison.
J Pers Med, 2013 Jan 01; 3(4). PMID: 25562729    Free PMC article.
Review.
The future of breast cancer systemic therapy: the next 10 years.
Melinda L Telli, George W Sledge.
J Mol Med (Berl), 2015 Jan 09; 93(2). PMID: 25566982
Review.
The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis.
C C Engels, A Charehbili, +10 authors, P J K Kuppen.
Breast Cancer Res Treat, 2015 Jan 27; 149(3). PMID: 25616355    Free PMC article.
The 21-gene recurrence score complements IBTR! Estimates in early-stage, hormone receptor-positive, HER2-normal, lymph node-negative breast cancer.
Nikhil G Thaker, Karen E Hoffman, +10 authors, Wendy A Woodward.
Springerplus, 2015 Feb 13; 4. PMID: 25674496    Free PMC article.
Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women.
Kristin Anderson, Patricia A Thompson, +11 authors, María Elena Martínez.
Springerplus, 2015 Feb 26; 3. PMID: 25713754    Free PMC article.
Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer.
Purificacion Estevez-Garcia, Fernando Rivera, +8 authors, Rocio Garcia-Carbonero.
Oncotarget, 2015 Mar 03; 6(8). PMID: 25730906    Free PMC article.
The value of personalizing medicine: medical oncologists' views on gene expression profiling in breast cancer treatment.
Yvonne Bombard, Linda Rozmovits, +3 authors, Deborah A Marshall.
Oncologist, 2015 Mar 10; 20(4). PMID: 25746345    Free PMC article.
Ki67--no evidence for its use in node-positive breast cancer.
Fabrice Andre, Monica Arnedos, +2 authors, Suzette Delaloge.
Nat Rev Clin Oncol, 2015 Mar 18; 12(5). PMID: 25781576
Review.
A retrospective study of the impact of 21-gene recurrence score assay on treatment choice in node positive micrometastatic breast cancer.
Thomas G Frazier, Kevin R Fox, +13 authors, Michael S Broder.
Pharmaceuticals (Basel), 2015 Mar 20; 8(1). PMID: 25789420    Free PMC article.
In the era of genomics, should tumor size be reconsidered as a criterion for neoadjuvant chemotherapy?
Xavier Pivot, Laura Mansi, +14 authors, Christian Villanueva.
Oncologist, 2015 Mar 22; 20(4). PMID: 25795632    Free PMC article.
Comprehensive molecular screening: from the RT-PCR to the RNA-seq.
Carlota Costa, Ana Giménez-Capitán, Niki Karachaliou, Rafael Rosell.
Transl Lung Cancer Res, 2013 Apr 01; 2(2). PMID: 25806219    Free PMC article.
Review.
[Molecular pathology for breast cancer: Importance of the gene expression profile].
C Denkert, B M Pfitzner, B I Heppner, M Dietel.
Pathologe, 2015 Apr 04; 36(2). PMID: 25836324
Review.
Optimal systemic therapy for early breast cancer in women: a clinical practice guideline.
A Eisen, G G Fletcher, +5 authors, members of the Early Breast Cancer Systemic Therapy Consensus Panel.
Curr Oncol, 2015 Apr 08; 22(Suppl 1). PMID: 25848340    Free PMC article.
Multigene prognostic tests in breast cancer: past, present, future.
Balázs Győrffy, Christos Hatzis, +3 authors, Lajos Pusztai.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848861    Free PMC article.
Highly Cited. Review.
Markers for the identification of late breast cancer recurrence.
Ivana Sestak, Jack Cuzick.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848913    Free PMC article.
Review.
Breast cancer subtype intertumor heterogeneity: MRI-based features predict results of a genomic assay.
Elizabeth J Sutton, Jung Hun Oh, +5 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2015 Apr 09; 42(5). PMID: 25850931    Free PMC article.
Highly Cited.
Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer.
Henrik J Johansson, Betzabe C Sanchez, +7 authors, Barbro K Linderholm.
Clin Proteomics, 2015 Apr 17; 12(1). PMID: 25878567    Free PMC article.
The E2F4 prognostic signature is also predictive of the pathological response of breast cancer to chemotherapy.
François Bertucci, Pascal Finetti, Daniel Birnbaum.
Breast Cancer Res, 2015 Apr 19; 17. PMID: 25887620    Free PMC article.
Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer.
Pavel Bouchal, Monika Dvořáková, +11 authors, Rudolf Nenutil.
Mol Cell Proteomics, 2015 Apr 24; 14(7). PMID: 25903579    Free PMC article.
Developing a new generation of breast cancer clinical gene expression tests.
Zuzana Kos, Torsten O Nielsen.
Breast Cancer Res, 2014 Jan 01; 16(4). PMID: 25928431    Free PMC article.
Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score.
Bradley M Turner, Kristin A Skinner, +6 authors, David G Hicks.
Mod Pathol, 2015 May 02; 28(7). PMID: 25932962
Role of genetic and molecular profiling in sarcomas.
Scott M Norberg, Sujana Movva.
Curr Treat Options Oncol, 2015 May 06; 16(5). PMID: 25939540
Review.
Development and validation of a novel platform-independent metastasis signature in human breast cancer.
Shuang G Zhao, Mark Shilkrut, +5 authors, Felix Y Feng.
PLoS One, 2015 May 15; 10(5). PMID: 25974184    Free PMC article.
Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo.
Stian Knappskog, Elisabet O Berge, +16 authors, Per E Lønning.
Mol Oncol, 2015 May 26; 9(8). PMID: 26004085    Free PMC article.
E2F4 Program Is Predictive of Progression and Intravesical Immunotherapy Efficacy in Bladder Cancer.
Chao Cheng, Frederick S Varn, Carmen J Marsit.
Mol Cancer Res, 2015 Jun 03; 13(9). PMID: 26032289    Free PMC article.
A Validated Model for Identifying Patients Unlikely to Benefit From the 21-Gene Recurrence Score Assay.
Michele M Gage, Martin Rosman, +6 authors, Lorraine Tafra.
Clin Breast Cancer, 2015 Jun 15; 15(6). PMID: 26072275    Free PMC article.
Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer.
Joseph A Sparano, Fengmin Zhao, +7 authors, Nancy E Davidson.
J Clin Oncol, 2015 Jun 17; 33(21). PMID: 26077235    Free PMC article.
Economic Impact of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in France.
Gregory Katz, Olivier Romano, +7 authors, Rémy Salmon.
PLoS One, 2015 Jun 19; 10(6). PMID: 26086912    Free PMC article.
Using proliferative markers and Oncotype DX in therapeutic decision-making for breast cancer: the B.C. experience.
E Baxter, L Gondara, +5 authors, S Tyldesley.
Curr Oncol, 2015 Jun 20; 22(3). PMID: 26089718    Free PMC article.
Prospective Clinical Utility Study of the Use of the 21-Gene Assay in Adjuvant Clinical Decision Making in Women With Estrogen Receptor-Positive Early Invasive Breast Cancer: Results From the SWITCH Study.
Joseph Gligorov, Xavier B Pivot, +11 authors, Francilian Breast Intergroup.
Oncologist, 2015 Jun 27; 20(8). PMID: 26112003    Free PMC article.
Designing a study to evaluate the benefit of a biomarker for selecting patient treatment.
Holly Janes, Marshall D Brown, Margaret S Pepe.
Stat Med, 2015 Jun 27; 34(27). PMID: 26112650    Free PMC article.
Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.
Tilak Khanal, Dasom Kim, +2 authors, Kyounghyun Kim.
Toxicol Lett, 2015 Jul 08; 237(3). PMID: 26149760    Free PMC article.
Tumor Cell Adhesion As a Risk Factor for Sentinel Lymph Node Metastasis in Primary Cutaneous Melanoma.
Alexander Meves, Ekaterina Nikolova, +10 authors, Vera J Suman.
J Clin Oncol, 2015 Jul 08; 33(23). PMID: 26150443    Free PMC article.
Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy--the SpheroNEO study.
Kathrin Halfter, Nina Ditsch, +9 authors, Behalf of the SpheroNEO Study Group.
BMC Cancer, 2015 Jul 15; 15. PMID: 26169261    Free PMC article.
Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer.
Scott Richard, Alan Wells, Joseph Connor, Fredric Price.
PLoS Curr, 2015 Jul 28; 7. PMID: 26213638    Free PMC article.
Racial variation in adjuvant chemotherapy initiation among breast cancer patients receiving oncotype DX testing.
Megan C Roberts, Morris Weinberger, +5 authors, Stephanie B Wheeler.
Breast Cancer Res Treat, 2015 Jul 29; 153(1). PMID: 26216535    Free PMC article.
Optimal approach in early breast cancer: Adjuvant and neoadjuvant treatment.
J Ribeiro, B Sousa, F Cardoso.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217109    Free PMC article.
Review.
Effect of 21-Gene RT-PCR Assay on Adjuvant Therapy and Outcomes in Patients With Stage I Breast Cancer.
Fanny Le Du, Ana M Gonzalez-Angulo, +3 authors, Naoto T Ueno.
Clin Breast Cancer, 2015 Aug 04; 15(6). PMID: 26233757    Free PMC article.
Prognostic Fifteen-Gene Signature for Early Stage Pancreatic Ductal Adenocarcinoma.
Dung-Tsa Chen, Ashley H Davis-Yadley, +5 authors, Mokenge Malafa.
PLoS One, 2015 Aug 08; 10(8). PMID: 26247463    Free PMC article.
Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.
D Merino, S W Lok, J E Visvader, G J Lindeman.
Oncogene, 2015 Aug 11; 35(15). PMID: 26257067
Review.
Is There a Role for Oncotype Dx Testing in Invasive Lobular Carcinoma?
Niamh Conlon, Dara S Ross, +3 authors, Lee K Tan.
Breast J, 2015 Aug 15; 21(5). PMID: 26271749    Free PMC article.
Progress in adjuvant chemotherapy for breast cancer: an overview.
Jesus Anampa, Della Makower, Joseph A Sparano.
BMC Med, 2015 Aug 19; 13. PMID: 26278220    Free PMC article.
Highly Cited. Review.
Population-based study of the effect of gene expression profiling on adjuvant chemotherapy use in breast cancer patients under the age of 65 years.
Arnold L Potosky, Suzanne C O'Neill, +8 authors, Marc D Schwartz.
Cancer, 2015 Aug 21; 121(22). PMID: 26291519    Free PMC article.
Development and verification of the PAM50-based Prosigna breast cancer gene signature assay.
Brett Wallden, James Storhoff, +16 authors, Joel S Parker.
BMC Med Genomics, 2015 Aug 25; 8. PMID: 26297356    Free PMC article.
Highly Cited.
Association Between Phosphorylated Histone H3 and Oncotype DX Recurrence Scores in Breast Cancer.
Lik Hang Lee, Paul E Swanson, +2 authors, Hua Yang.
Appl Immunohistochem Mol Morphol, 2015 Sep 16; 25(1). PMID: 26371428    Free PMC article.
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +28 authors, George W Sledge.
N Engl J Med, 2015 Sep 29; 373(21). PMID: 26412349    Free PMC article.
Highly Cited.
Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients.
Yukari Hato, Naoto Kondo, +8 authors, Tatsuya Toyama.
Int J Clin Oncol, 2015 Oct 21; 21(3). PMID: 26482374
Big Data: the challenge for small research groups in the era of cancer genomics.
Aisyah Mohd Noor, Lars Holmberg, Cheryl Gillett, Anita Grigoriadis.
Br J Cancer, 2015 Oct 23; 113(10). PMID: 26492224    Free PMC article.
Review.
SEOM clinical guidelines in early-stage breast cancer 2015.
J A Garcia-Saenz, B Bermejo, +7 authors, E Ciruelos.
Clin Transl Oncol, 2015 Oct 27; 17(12). PMID: 26497356    Free PMC article.
Identifying patients at high risk of breast cancer recurrence: strategies to improve patient outcomes.
Yehoda M Martei, Jennifer M Matro.
Breast Cancer (Dove Med Press), 2015 Oct 28; 7. PMID: 26504408    Free PMC article.
Review.
Chemotherapy and the recurrence score--results as expected?
Lajos Pusztai.
Nat Rev Clin Oncol, 2015 Nov 11; 12(12). PMID: 26552957
Recognizing the Limitations of Cancer Overdiagnosis Studies: A First Step Towards Overcoming Them.
Ruth Etzioni, Roman Gulati.
J Natl Cancer Inst, 2015 Nov 20; 108(3). PMID: 26582245    Free PMC article.
Review.
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
Oakley C Olson, Johanna A Joyce.
Nat Rev Cancer, 2015 Nov 26; 15(12). PMID: 26597527
Highly Cited. Review.
Racial Variation in the Uptake of Oncotype DX Testing for Early-Stage Breast Cancer.
Megan C Roberts, Morris Weinberger, +5 authors, Stephanie B Wheeler.
J Clin Oncol, 2015 Nov 26; 34(2). PMID: 26598755    Free PMC article.
Quantitative Gene Expression by Recurrence Score in ER-Positive Breast Cancer, by Age.
Sandra M Swain, Raquel Nunes, +2 authors, Amy P Sing.
Adv Ther, 2015 Nov 28; 32(12). PMID: 26610382    Free PMC article.
A Prospective Comparison of the 21-Gene Recurrence Score and the PAM50-Based Prosigna in Estrogen Receptor-Positive Early-Stage Breast Cancer.
Michael D Alvarado, Che Prasad, +5 authors, Christos J Markopoulos.
Adv Ther, 2015 Nov 28; 32(12). PMID: 26610383    Free PMC article.
Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.
Melody J Xu, Jay F Dorsey, +7 authors, Gary D Kao.
Oncologist, 2015 Nov 29; 21(1). PMID: 26614709    Free PMC article.
Review.
Biomarkers in Breast Cancer - An Update.
M Schmidt, P A Fasching, M W Beckmann, H Kölbl.
Geburtshilfe Frauenheilkd, 2012 Sep 01; 72(9). PMID: 26640290    Free PMC article.
Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients.
Xi Wang, Brian Z Ring, +5 authors, Shuyuan Yeh.
BMC Clin Pathol, 2015 Dec 15; 15. PMID: 26664297    Free PMC article.
Recommendations from the EGAPP Working Group: does the use of Oncotype DX tumor gene expression profiling to guide treatment decisions improve outcomes in patients with breast cancer?
Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group*.
Genet Med, 2015 Dec 19; 18(8). PMID: 26681310
Breast cancer intrinsic subtype classification, clinical use and future trends.
Xiaofeng Dai, Ting Li, +4 authors, Bozhi Shi.
Am J Cancer Res, 2015 Dec 23; 5(10). PMID: 26693050    Free PMC article.
Highly Cited. Review.
Cost effectiveness of personalized treatment in women with early breast cancer: the application of OncotypeDX and Adjuvant! Online to guide adjuvant chemotherapy in Austria.
B Jahn, U Rochau, +7 authors, U Siebert.
Springerplus, 2015 Dec 23; 4. PMID: 26693110    Free PMC article.
Correlative Analysis of miRNA Expression and Oncotype Dx Recurrence Score in Estrogen Receptor Positive Breast Carcinomas.
Rajyasree Emmadi, Emanuele Canestrari, +4 authors, Elizabeth Wiley.
PLoS One, 2015 Dec 31; 10(12). PMID: 26717565    Free PMC article.
Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.
Dennis C Sgroi, Judy-Anne W Chapman, +10 authors, Michael Pollak.
Breast Cancer Res, 2016 Jan 06; 18(1). PMID: 26728744    Free PMC article.
AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway.
Roman Hrstka, Pavla Bouchalova, +4 authors, Borivoj Vojtesek.
Mol Oncol, 2016 Jan 07; 10(5). PMID: 26733232    Free PMC article.
Breast cancer subtypes: morphologic and biologic characterization.
Shahla Masood.
Womens Health (Lond), 2016 Jan 13; 12(1). PMID: 26756229    Free PMC article.
Adjuvant treatment for older women with invasive breast cancer.
Trevor A Jolly, Grant R Williams, +4 authors, Hyman B Muss.
Womens Health (Lond), 2016 Jan 16; 12(1). PMID: 26767315    Free PMC article.
Review.
Efficacy of chemotherapy after hormone therapy for hormone receptor-positive metastatic breast cancer.
Ryutaro Mori, Yasuko Nagao.
SAGE Open Med, 2014 Jan 01; 2. PMID: 26770749    Free PMC article.
Estimating treatment effect in a proportional hazards model in randomized clinical trials with all-or-nothing compliance.
Shuli Li, Robert J Gray.
Biometrics, 2016 Jan 23; 72(3). PMID: 26799700    Free PMC article.
Comprehensive Histologic Scoring to Maximize the Predictability of Pathology-generated Equation of Breast Cancer Oncotype DX Recurrence Score.
Thaer Khoury, Xiao Huang, +3 authors, Mateusz Opyrchal.
Appl Immunohistochem Mol Morphol, 2016 Jan 26; 24(10). PMID: 26808126    Free PMC article.
Neoadjuvant endocrine therapy in breast cancer: current role and future perspectives.
Romualdo Barroso-Sousa, Danilo D A Fonseca Reis Silva, Joao Victor Machado Alessi, Max Senna Mano.
Ecancermedicalscience, 2016 Jan 30; 10. PMID: 26823678    Free PMC article.
Review.
Molecular Imaging of Biomarkers in Breast Cancer.
Gary A Ulaner, Chris C Riedl, +3 authors, Wolfgang Weber.
J Nucl Med, 2016 Feb 03; 57 Suppl 1. PMID: 26834103    Free PMC article.
Review.
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline.
Lyndsay N Harris, Nofisat Ismaila, +11 authors, American Society of Clinical Oncology.
J Clin Oncol, 2016 Feb 10; 34(10). PMID: 26858339    Free PMC article.
Highly Cited. Review.
Targeted therapies with companion diagnostics in the management of breast cancer: current perspectives.
Meagan B Myers.
Pharmgenomics Pers Med, 2016 Feb 10; 9. PMID: 26858530    Free PMC article.
Review.
Patterns in target-directed breast cancer research.
Sofia Torres, Christine Simmons, +3 authors, Maureen Trudeau.
Springerplus, 2016 Feb 16; 5. PMID: 26877907    Free PMC article.
Does estrogen receptor determination affect prognosis in early stage breast cancers?
Nilufer Bulut, Kadri Altundag.
Int J Clin Exp Med, 2016 Feb 18; 8(11). PMID: 26885091    Free PMC article.
A Radio-genomics Approach for Identifying High Risk Estrogen Receptor-positive Breast Cancers on DCE-MRI: Preliminary Results in Predicting OncotypeDX Risk Scores.
Tao Wan, B Nicolas Bloch, +5 authors, Anant Madabhushi.
Sci Rep, 2016 Feb 19; 6. PMID: 26887643    Free PMC article.
Low Concordance between Gene Expression Signatures in ER Positive HER2 Negative Breast Carcinoma Could Impair Their Clinical Application.
Enora Laas, Peter Mallon, +3 authors, Fabien Reyal.
PLoS One, 2016 Feb 20; 11(2). PMID: 26895349    Free PMC article.
Cancer stem cells and chemoresistance: The smartest survives the raid.
Jihe Zhao.
Pharmacol Ther, 2016 Feb 24; 160. PMID: 26899500    Free PMC article.
Highly Cited. Review.
Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study.
Miguel Martin, Jan C Brase, +15 authors, Alvaro Rodriguez-Lescure.
Breast Cancer Res Treat, 2016 Feb 26; 156(1). PMID: 26909792    Free PMC article.
The impact of the 21-gene assay on adjuvant treatment decisions in oestrogen receptor-positive early breast cancer: a prospective study.
Anna Kuchel, Tim Robinson, +8 authors, Jeremy P Braybrooke.
Br J Cancer, 2016 Mar 10; 114(7). PMID: 26954715    Free PMC article.
Estrogen receptor-alpha as a predictive biomarker in endometrioid endometrial cancer.
Floor J Backes, Christopher J Walker, +5 authors, Adrian A Suarez.
Gynecol Oncol, 2016 Mar 10; 141(2). PMID: 26957478    Free PMC article.
Translating RNA sequencing into clinical diagnostics: opportunities and challenges.
Sara A Byron, Kendall R Van Keuren-Jensen, +2 authors, David W Craig.
Nat Rev Genet, 2016 Mar 22; 17(5). PMID: 26996076    Free PMC article.
Highly Cited. Review.
Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of Ki67 assay according to histology: prognostic relevance for resected early stage 'pure' and 'mixed' lobular breast cancer.
Luisa Carbognin, Isabella Sperduti, +13 authors, Emilio Bria.
J Exp Clin Cancer Res, 2016 Mar 24; 35. PMID: 27000271    Free PMC article.
Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013.
Tari A King, Jaclyn P Lyman, +17 authors, Clifford A Hudis.
J Clin Oncol, 2016 Mar 24; 34(20). PMID: 27001590    Free PMC article.
Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level.
Theresa A Koleck, Yvette P Conley.
Breast Cancer (Dove Med Press), 2016 Mar 30; 8. PMID: 27022301    Free PMC article.
An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.
Skye H Cheng, Chen-Fang Horng, +6 authors, Andrew T Huang.
EBioMedicine, 2016 Apr 15; 5. PMID: 27077114    Free PMC article.
Impact of Oncotype DX Recurrence Score on Treatment Decisions: Results of a Prospective Multicenter Study in Turkey.
Vahit Ozmen, Ajlan Atasoy, +7 authors, Pinar Saip.
Cureus, 2016 Apr 16; 8(3). PMID: 27081583    Free PMC article.
Signatures of breast cancer metastasis at a glance.
George S Karagiannis, Sumanta Goswami, +2 authors, John S Condeelis.
J Cell Sci, 2016 Apr 17; 129(9). PMID: 27084578    Free PMC article.
Review.
Underutilization of gene expression profiling for early-stage breast cancer in California.
Rosemary D Cress, Yingjia S Chen, +2 authors, Kenneth W Kizer.
Cancer Causes Control, 2016 Apr 22; 27(6). PMID: 27097910    Free PMC article.
Patient-Centered Communication for Discussing Oncotype DX Testing.
Megan C Roberts, Amy Bryson, +4 authors, Stephanie B Wheeler.
Cancer Invest, 2016 Apr 29; 34(5). PMID: 27124287    Free PMC article.
Data Requirements for Model-Based Cancer Prognosis Prediction.
Lori A Dalton, Mohammadmahdi R Yousefi.
Cancer Inform, 2015 Jan 01; 14(Suppl 5). PMID: 27127404    Free PMC article.
Increased Proportion of Variance Explained and Prediction Accuracy of Survival of Breast Cancer Patients with Use of Whole-Genome Multiomic Profiles.
Ana I Vazquez, Yogasudha Veturi, +4 authors, Gustavo de Los Campos.
Genetics, 2016 May 01; 203(3). PMID: 27129736    Free PMC article.
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others.
John M S Bartlett, Jane Bayani, +18 authors, OPTIMA TMG.
J Natl Cancer Inst, 2016 May 01; 108(9). PMID: 27130929    Free PMC article.
MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.
Hui Li, Yitan Zhu, +13 authors, Maryellen L Giger.
Radiology, 2016 Oct 19; 281(2). PMID: 27144536    Free PMC article.
Highly Cited.
Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment.
Keith T Schmidt, Cindy H Chau, Douglas K Price, William D Figg.
J Clin Pharmacol, 2016 May 21; 56(12). PMID: 27197880    Free PMC article.
Review.
Utilization and impact of 21-gene recurrence score assay for breast cancer in clinical practice across the United States: lessons learned from the 2010 to 2012 National Cancer Data Base analysis.
Amila Orucevic, Robert E Heidel, John L Bell.
Breast Cancer Res Treat, 2016 May 22; 157(3). PMID: 27206678    Free PMC article.
Association between partial-volume corrected SUVmax and Oncotype DX recurrence score in early-stage, ER-positive/HER2-negative invasive breast cancer.
Su Hyun Lee, Seunggyun Ha, +9 authors, Gi Jeong Cheon.
Eur J Nucl Med Mol Imaging, 2016 May 23; 43(9). PMID: 27209424
Prognostic Impact of the Combination of Recurrence Score and Quantitative Estrogen Receptor Expression (ESR1) on Predicting Late Distant Recurrence Risk in Estrogen Receptor-Positive Breast Cancer After 5 Years of Tamoxifen: Results From NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-28 and B-14.
Norman Wolmark, Eleftherios P Mamounas, +6 authors, Soonmyung Paik.
J Clin Oncol, 2016 May 25; 34(20). PMID: 27217450    Free PMC article.
Use of Gene Expression Profiling and Chemotherapy in Early-Stage Breast Cancer: A Study of Linked Electronic Medical Records, Cancer Registry Data, and Genomic Data Across Two Health Care Systems.
Anosheh Afghahi, Maya Mathur, +14 authors, Allison W Kurian.
J Oncol Pract, 2016 May 26; 12(6). PMID: 27221993    Free PMC article.
The Role of the 21-Gene Recurrence Score in Breast Cancer Treatment.
Josee-Lyne Ethier, Eitan Amir.
Mol Diagn Ther, 2016 May 29; 20(4). PMID: 27235162
Review.
Breast cancer multigene testing trends and impact on chemotherapy use.
G Thomas Ray, Jeanne Mandelblatt, +4 authors, Tracy A Lieu.
Am J Manag Care, 2016 Jun 09; 22(5). PMID: 27266581    Free PMC article.
Associations between metabolic syndrome, breast cancer recurrence, and the 21-gene recurrence score assay.
Jeanette Muniz, Kelley M Kidwell, N Lynn Henry.
Breast Cancer Res Treat, 2016 Jun 09; 157(3). PMID: 27271766    Free PMC article.
Breast cancer: The 21-gene recurrence score - biology remains at the forefront.
Shannon L Puhalla, Nancy E Davidson.
Nat Rev Clin Oncol, 2016 Jun 15; 13(8). PMID: 27296295
Association between Ultrasound Features and the 21-Gene Recurrence Score Assays in Patients with Oestrogen Receptor-Positive, HER2-Negative, Invasive Breast Cancer.
Eun Young Chae, Woo Kyung Moon, +8 authors, Sei Hyun Ahn.
PLoS One, 2016 Jul 01; 11(6). PMID: 27362843    Free PMC article.
Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.
H S Okuma, F Koizumi, +10 authors, K Tamura.
Br J Cancer, 2016 Jul 15; 115(4). PMID: 27415010    Free PMC article.
Relational Network for Knowledge Discovery through Heterogeneous Biomedical and Clinical Features.
Huaidong Chen, Wei Chen, +3 authors, Xiaobo Zhou.
Sci Rep, 2016 Jul 19; 6. PMID: 27427091    Free PMC article.
21-Gene recurrence score decreases receipt of chemotherapy in ER+ early-stage breast cancer: an analysis of the NCDB 2010-2013.
Benjamin M Parsons, Jeffrey Landercasper, +3 authors, Leah L Dietrich.
Breast Cancer Res Treat, 2016 Aug 11; 159(2). PMID: 27507245    Free PMC article.
Multiparametric Genomic Assays for Breast Cancer: Time for the Next Generation?
Adam M Brufsky, Nancy E Davidson.
Clin Cancer Res, 2016 Aug 16; 22(20). PMID: 27521446    Free PMC article.
Breast carcinoma with an Oncotype Dx recurrence score <18: Rate of distant metastases in a large series with clinical follow-up.
Hannah Y Wen, Melissa Krystel-Whittemore, +7 authors, Edi Brogi.
Cancer, 2016 Aug 16; 123(1). PMID: 27526056    Free PMC article.
Implementing personalized medicine with asymmetric information on prevalence rates.
Fernando Antoñanzas, Carmelo A Juárez-Castelló, Roberto Rodríguez-Ibeas.
Health Econ Rev, 2016 Aug 20; 6(1). PMID: 27539222    Free PMC article.
ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.
Daniel L Hertz, N Lynn Henry, +12 authors, James M Rae.
Physiol Genomics, 2016 Aug 21; 48(9). PMID: 27542969    Free PMC article.
Prognostic Value of a BCSC-associated MicroRNA Signature in Hormone Receptor-Positive HER2-Negative Breast Cancer.
Chang Gong, Weige Tan, +16 authors, Erwei Song.
EBioMedicine, 2016 Aug 28; 11. PMID: 27566954    Free PMC article.
Improving Pathological Assessment of Breast Cancer by Employing Array-Based Transcriptome Analysis.
Zsuzsanna Mihály, Balázs Győrffy.
Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605190    Free PMC article.
Review.
From High-Throughput Microarray-Based Screening to Clinical Application: The Development of a Second Generation Multigene Test for Breast Cancer Prognosis.
Jan C Brase, Ralf Kronenwett, +2 authors, Marcus Schmidt.
Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605191    Free PMC article.
Review.
Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?
Sandra Casimiro, Arlindo R Ferreira, +2 authors, Luis Costa.
Int J Mol Sci, 2016 Sep 14; 17(9). PMID: 27618899    Free PMC article.
Review.
Statistical controversies in clinical research: prognostic gene signatures are not (yet) useful in clinical practice.
S Michiels, N Ternès, F Rotolo.
Ann Oncol, 2016 Sep 17; 27(12). PMID: 27634691    Free PMC article.
Review.
The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics.
Hadar Goldvaser, Shulamith Rizel, +6 authors, Rinat Yerushalmi.
Int J Endocrinol, 2016 Sep 21; 2016. PMID: 27648070    Free PMC article.
Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer.
Keun-Wook Lee, Sung Sook Lee, +18 authors, Ju-Seog Lee.
Clin Cancer Res, 2016 Sep 23; 22(24). PMID: 27654712    Free PMC article.
The combined endocrine receptor in breast cancer, a novel approach to traditional hormone receptor interpretation and a better discriminator of outcome than ER and PR alone.
Esther J Campbell, Mathias Tesson, +3 authors, Joanne Edwards.
Br J Cancer, 2016 Sep 23; 115(8). PMID: 27657341    Free PMC article.
Best Practices for Genomic Assay Testing in Early-Stage Breast Cancer: Clinical and Medicolegal Perspectives.
Andrew D Seidman, Darius K Amjadi, Tammy De La Melena, Darren Wheeler.
Popul Health Manag, 2016 Sep 30; 20(4). PMID: 27684734    Free PMC article.
The analytical validation of the Oncotype DX Recurrence Score assay.
Frederick L Baehner.
Ecancermedicalscience, 2016 Oct 13; 10. PMID: 27729940    Free PMC article.
Progress in the clinical detection of heterogeneity in breast cancer.
Jun-Long Song, Chuang Chen, Jing-Ping Yuan, Sheng-Rong Sun.
Cancer Med, 2016 Oct 25; 5(12). PMID: 27774765    Free PMC article.
Review.
Major clinical research advances in gynecologic cancer in 2015.
Dong Hoon Suh, Miseon Kim, +2 authors, Jae Weon Kim.
J Gynecol Oncol, 2016 Oct 25; 27(6). PMID: 27775259    Free PMC article.
Review.
Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer.
Kelly K Hunt, Cansu Karakas, +13 authors, Khandan Keyomarsi.
Clin Cancer Res, 2016 Nov 25; 23(12). PMID: 27881578    Free PMC article.
Hormonal Modulation of Breast Cancer Gene Expression: Implications for Intrinsic Subtyping in Premenopausal Women.
Sarah M Bernhardt, Pallave Dasari, +3 authors, Wendy V Ingman.
Front Oncol, 2016 Nov 30; 6. PMID: 27896218    Free PMC article.
Review.
A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse.
Aleix Prat, Ana Lluch, +22 authors, Emilio Alba.
Clin Cancer Res, 2016 Dec 03; 23(12). PMID: 27903675    Free PMC article.
Optimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer.
Hyun-Seok Kim, Christopher B Umbricht, +22 authors, Leslie Cope.
J Clin Oncol, 2016 Dec 22; 34(36). PMID: 27998227    Free PMC article.
Second Opinions From Medical Oncologists for Early-Stage Breast Cancer: Prevalence, Correlates, and Consequences.
Allison W Kurian, Christopher R Friese, +5 authors, Steven J Katz.
JAMA Oncol, 2016 Dec 30; 3(3). PMID: 28033448    Free PMC article.
Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset.
Michael R Harowicz, Timothy J Robinson, +4 authors, Maciej A Mazurowski.
Breast Cancer Res Treat, 2017 Jan 09; 162(1). PMID: 28064383    Free PMC article.
Precision medicine in early breast cancer-can this apply to radiotherapy?
Samuel G W Ow, Soo-Chin Lee.
J Thorac Dis, 2017 Jan 10; 8(11). PMID: 28066563    Free PMC article.
Associations between pathologic tumor features and preadjuvant therapy cognitive performance in women diagnosed with breast cancer.
Theresa A Koleck, Catherine M Bender, +7 authors, Yvette P Conley.
Cancer Med, 2017 Jan 14; 6(2). PMID: 28083945    Free PMC article.
The Complexity of Achieving the Promise of Precision Breast Cancer Screening.
Jennifer S Haas.
J Natl Cancer Inst, 2017 Jan 29; 109(5). PMID: 28130476    Free PMC article.
Ki-67 as a prognostic marker according to breast cancer molecular subtype.
Nahed A Soliman, Shaimaa M Yussif.
Cancer Biol Med, 2017 Feb 06; 13(4). PMID: 28154782    Free PMC article.
Outcomes in patients with early-stage breast cancer who underwent a 21-gene expression assay.
Carlos H Barcenas, Akshara Raghavendra, +10 authors, Debu Tripathy.
Cancer, 2017 Feb 16; 123(13). PMID: 28199747    Free PMC article.
Integrated precision medicine: the role of electronic health records in delivering personalized treatment.
Amy Sitapati, Hyeoneui Kim, +5 authors, Lucila Ohno-Machado.
Wiley Interdiscip Rev Syst Biol Med, 2017 Feb 17; 9(3). PMID: 28207198    Free PMC article.
Review.
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays.
David M Hyams, Eric Schuur, +7 authors, Aníbal Nuñez De Pierro.
J Surg Oncol, 2017 Feb 18; 115(6). PMID: 28211064    Free PMC article.
Review.
Oncotype DX breast cancer recurrence score can be predicted with a novel nomogram using clinicopathologic data.
Amila Orucevic, John L Bell, Alison P McNabb, Robert E Heidel.
Breast Cancer Res Treat, 2017 Mar 01; 163(1). PMID: 28243897    Free PMC article.
Personalized chemotherapy selection for breast cancer using gene expression profiles.
Kaixian Yu, Qing-Xiang Amy Sang, +6 authors, Jinfeng Zhang.
Sci Rep, 2017 Mar 04; 7. PMID: 28256629    Free PMC article.
Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey.
Vahit Özmen, Ajlan Atasoy, +9 authors, Pınar Saip.
J Breast Health, 2016 Jan 01; 12(3). PMID: 28331745    Free PMC article.
Low Recombination Proficiency Score (RPS) Predicts Heightened Sensitivity to DNA-Damaging Chemotherapy in Breast Cancer.
Sean P Pitroda, Riyue Bao, +2 authors, Philip P Connell.
Clin Cancer Res, 2017 Mar 28; 23(15). PMID: 28341751    Free PMC article.
Endocrine therapy initiation, discontinuation and adherence and breast imaging among 21-gene recurrence score assay-eligible women under age 65.
Suzanne C O'Neill, Claudine Isaacs, +8 authors, Arnold L Potosky.
Breast Cancer Res, 2017 Apr 01; 19(1). PMID: 28359319    Free PMC article.
Distribution patterns of 21-gene recurrence score in 980 Chinese estrogen receptor-positive, HER2-negative early breast cancer patients.
Jiayi Wu, Yan Fang, +11 authors, Kunwei Shen.
Oncotarget, 2017 Apr 14; 8(24). PMID: 28404972    Free PMC article.
Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial.
Harry D Bear, Wen Wan, +8 authors, Amy P Sing.
J Surg Oncol, 2017 Apr 14; 115(8). PMID: 28407247    Free PMC article.
Adjuvant treatment recommendations for patients with ER-positive/HER2-negative early breast cancer by Swiss tumor boards using the 21-gene recurrence score (SAKK 26/10).
Bernhard C Pestalozzi, Christoph Tausch, +17 authors, Swiss Group for Clinical Cancer Research (SAKK).
BMC Cancer, 2017 Apr 15; 17(1). PMID: 28407750    Free PMC article.
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer.
Jinil Han, Yoon-La Choi, +11 authors, Young Kee Shin.
Breast Cancer Res Treat, 2017 Apr 15; 164(1). PMID: 28409241    Free PMC article.
Comparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer.
Sung Gwe Ahn, Jae-Hoon Lee, +8 authors, Seung Il Kim.
PLoS One, 2017 Apr 19; 12(4). PMID: 28419166    Free PMC article.
An exploratory study of host polymorphisms in genes that clinically characterize breast cancer tumors and pretreatment cognitive performance in breast cancer survivors.
Theresa A Koleck, Catherine M Bender, +7 authors, Yvette P Conley.
Breast Cancer (Dove Med Press), 2017 Apr 21; 9. PMID: 28424560    Free PMC article.
Relationship between IHC4 score and response to neo-adjuvant chemotherapy in estrogen receptor-positive breast cancer.
A Sheri, I E Smith, +3 authors, M Dowsett.
Breast Cancer Res Treat, 2017 Apr 28; 164(2). PMID: 28447240    Free PMC article.
Linalool prevents oxidative stress activated protein kinases in single UVB-exposed human skin cells.
Srithar Gunaseelan, Agilan Balupillai, +8 authors, Pierson Rathinaraj.
PLoS One, 2017 May 04; 12(5). PMID: 28467450    Free PMC article.
Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines.
Synnøve Yndestad, Eilin Austreid, +3 authors, Hans P Eikesdal.
Oncotarget, 2017 May 06; 8(25). PMID: 28476032    Free PMC article.
Uptake of a 21-gene expression assay in breast cancer practice: views of academic and community-based oncologists.
M A O'Brien, S Dhesy-Thind, +3 authors, E Grunfeld.
Curr Oncol, 2017 May 12; 24(2). PMID: 28490937    Free PMC article.
A high-throughput method to detect RNA profiling by integration of RT-MLPA with next generation sequencing technology.
Jing Wang, Xue Yang, +5 authors, Jidong Gao.
Oncotarget, 2017 May 26; 8(28). PMID: 28545022    Free PMC article.
Clinical utility of gene-expression signatures in early stage breast cancer.
Maryann Kwa, Andreas Makris, Francisco J Esteva.
Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
Highly Cited. Review.
Adjuvant endocrine therapy alone in patients with node-positive, luminal A type breast cancer.
Sungmin Park, Se Kyung Lee, +7 authors, Seok Jin Nam.
Medicine (Baltimore), 2017 Jun 01; 96(22). PMID: 28562530    Free PMC article.
The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis.
Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jun 04; 165(1). PMID: 28577081    Free PMC article.
Clinical use of the Oncotype DX genomic test to guide treatment decisions for patients with invasive breast cancer.
Terri P McVeigh, Michael J Kerin.
Breast Cancer (Dove Med Press), 2017 Jun 16; 9. PMID: 28615971    Free PMC article.
Review.
Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score.
Sunitha B Thakur, Manuela Durando, +5 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Jun 24; 47(2). PMID: 28640531    Free PMC article.
Sequential versus concurrent chemotherapy for adjuvant breast cancer: does dose intensity matter?
N LeVasseur, S K Chia.
Br J Cancer, 2017 Jun 24; 117(2). PMID: 28641309    Free PMC article.
Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine.
Jane Bayani, Cindy Q Yao, +13 authors, John M S Bartlett.
NPJ Breast Cancer, 2017 Jun 27; 3. PMID: 28649643    Free PMC article.
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades.
Laura J Esserman, Christina Yau, +9 authors, Linda S Lindström.
JAMA Oncol, 2017 Jul 01; 3(11). PMID: 28662222    Free PMC article.
Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.
Krysta Mila Coyle, Jeanette E Boudreau, Paola Marcato.
Biomed Res Int, 2017 Jul 08; 2017. PMID: 28685150    Free PMC article.
Review.
21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer.
Gulisa Turashvili, Joanne F Chou, +5 authors, Hannah Y Wen.
Breast Cancer Res Treat, 2017 Jul 14; 166(1). PMID: 28702894    Free PMC article.
Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma.
Sunniva Stordal Bjørklund, Anshuman Panda, +12 authors, Gyan Bhanot.
Sci Rep, 2017 Jul 19; 7(1). PMID: 28717182    Free PMC article.
Internet tools to enhance breast cancer care.
Shlomit Strulov Shachar, Hyman B Muss.
NPJ Breast Cancer, 2016 Apr 27; 2. PMID: 28721377    Free PMC article.
Learning from big data: are we undertreating older women with high-risk breast cancer?
Joseph A Sparano, Hyman Muss.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721380    Free PMC article.
Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study.
Valentina I Petkov, Dave P Miller, +21 authors, Steven Shak.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721379    Free PMC article.
Highly Cited.
A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients.
Seong-Min Park, Eun-Young Choi, +2 authors, Youn-Jae Kim.
Clin Epigenetics, 2017 Jul 28; 9. PMID: 28748001    Free PMC article.
Identifying Biomarkers to Select Patients with Early Breast Cancer Suitable for Extended Adjuvant Endocrine Therapy.
Ivana Sestak.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785181    Free PMC article.
Review.
Exploitation of Gene Expression and Cancer Biomarkers in Paving the Path to Era of Personalized Medicine.
Hala Fawzy Mohamed Kamel, Hiba Saeed A Bagader Al-Amodi.
Genomics Proteomics Bioinformatics, 2017 Aug 17; 15(4). PMID: 28813639    Free PMC article.
Review.
Adjusting for covariates in evaluating markers for selecting treatment, with application to guiding chemotherapy for treating estrogen-receptor-positive, node-positive breast cancer.
Holly Janes, Marshall D Brown, +2 authors, William E Barlow.
Contemp Clin Trials, 2017 Aug 19; 63. PMID: 28818434    Free PMC article.
Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes.
Elsa Curtit, Xavier Pivot, +35 authors, David G Cox.
Breast Cancer Res, 2017 Aug 24; 19(1). PMID: 28830573    Free PMC article.
Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.
Melissa A Troester, Xuezheng Sun, +16 authors, Charles M Perou.
J Natl Cancer Inst, 2017 Sep 02; 110(2). PMID: 28859290    Free PMC article.
The association between smoking and breast cancer characteristics and outcome.
Hadar Goldvaser, Omer Gal, +6 authors, Rinat Yerushalmi.
BMC Cancer, 2017 Sep 07; 17(1). PMID: 28874120    Free PMC article.
Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?
Umar Wazir, Kinan Mokbel, Amtul Carmichael, Kefah Mokbel.
Cell Mol Biol Lett, 2017 Sep 08; 22. PMID: 28878809    Free PMC article.
Review.
Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer.
Alberto Peláez-García, Laura Yébenes, +9 authors, David Hardisson.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886093    Free PMC article.
Gene expression profiling of calcifications in breast cancer.
Sung Ui Shin, Jeonghoon Lee, +7 authors, Woo Kyung Moon.
Sci Rep, 2017 Sep 14; 7(1). PMID: 28900139    Free PMC article.
Clinical outcomes in patients with node-negative breast cancer treated based on the recurrence score results: evidence from a large prospectively designed registry.
Salomon M Stemmer, Mariana Steiner, +21 authors, Nicky Liebermann.
NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900633    Free PMC article.
Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.
Ana C Gregório, Manuela Lacerda, +3 authors, João Nuno Moreira.
Pathol Oncol Res, 2017 Sep 16; 24(4). PMID: 28913723
Review.
How Do Patients Experience Individualized Medicine? A Qualitative Interview-based Study of Gene Expression Analyses in the Treatment of Breast Cancer.
Sebastian Schleidgen, Sandra Thiersch, Rachel Wuerstlein, Georg Marckmann.
Geburtshilfe Frauenheilkd, 2017 Sep 30; 77(9). PMID: 28959062    Free PMC article.
Case-only approach to identifying markers predicting treatment effects on the relative risk scale.
James Y Dai, C Jason Liang, +2 authors, Holly Janes.
Biometrics, 2017 Sep 30; 74(2). PMID: 28960244    Free PMC article.
Radiomics: the bridge between medical imaging and personalized medicine.
Philippe Lambin, Ralph T H Leijenaar, +17 authors, Sean Walsh.
Nat Rev Clin Oncol, 2017 Oct 05; 14(12). PMID: 28975929
Highly Cited. Review.
Prognostic immune-related gene models for breast cancer: a pooled analysis.
Jianli Zhao, Ying Wang, +6 authors, Kai Chen.
Onco Targets Ther, 2017 Oct 06; 10. PMID: 28979134    Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer.
E Nilüfer Güler.
Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373    Free PMC article.
Review.
Clinical utility of multigene profiling assays in early-stage breast cancer.
M C Chang, L H Souter, +6 authors, Molecular Oncology Advisory Committee.
Curr Oncol, 2017 Nov 02; 24(5). PMID: 29089811    Free PMC article.
Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.
Volker Möbus, Susanne Hell, Marcus Schmidt.
Geburtshilfe Frauenheilkd, 2017 Nov 03; 77(10). PMID: 29093601    Free PMC article.
Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score: A study based on in vitro chemoresponse assay.
Sung Gwe Ahn, Soong June Bae, +4 authors, Joon Jeong.
PLoS One, 2017 Nov 09; 12(11). PMID: 29117208    Free PMC article.
Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer.
Andrew Dodson, David Okonji, +6 authors, Mitch Dowsett.
Breast Cancer Res Treat, 2017 Nov 13; 168(1). PMID: 29128896    Free PMC article.
21-Gene Recurrence Score for prognosis and prediction of taxane benefit after adjuvant chemotherapy plus endocrine therapy: results from NSABP B-28/NRG Oncology.
Eleftherios P Mamounas, Gong Tang, +14 authors, Norman Wolmark.
Breast Cancer Res Treat, 2017 Nov 13; 168(1). PMID: 29128898    Free PMC article.
First Prospective Multicenter Italian Study on the Impact of the 21-Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer.
Maria Vittoria Dieci, Valentina Guarneri, +15 authors, PierFranco Conte.
Oncologist, 2017 Nov 15; 23(3). PMID: 29133514    Free PMC article.
TNBC vs. Non-TNBC: A Five-Year Retrospective Review of Differences in Mean Age, Family History, Smoking History and Stage at Diagnosis at an Inner City University Program.
Khurram Tariq, Fauzia Rana.
World J Oncol, 2013 Dec 01; 4(6). PMID: 29147364    Free PMC article.
The Era of Multigene Panels Comes? The Clinical Utility of Oncotype DX and MammaPrint.
Ling Xin, Yin-Hua Liu, Tracey A Martin, Wen G Jiang.
World J Oncol, 2017 Nov 18; 8(2). PMID: 29147432    Free PMC article.
Review.
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Oluwadamilola M Fayanju, Ko Un Park, Anthony Lucci.
Ann Surg Oncol, 2017 Nov 22; 25(2). PMID: 29159748    Free PMC article.
Review.
Feasibility analysis of early temporal kinetics as a surrogate marker for breast tumor type, grade, and aggressiveness.
Laura Heacock, Alana A Lewin, +6 authors, Linda Moy.
J Magn Reson Imaging, 2017 Nov 28; 47(6). PMID: 29178258    Free PMC article.
Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.
Nita Amornsiripanitch, Vicky T Nguyen, +4 authors, Savannah C Partridge.
J Magn Reson Imaging, 2017 Nov 28; 48(1). PMID: 29178616    Free PMC article.
Large-scale DNA organization is a prognostic marker of breast cancer survival.
Martial Guillaud, Qian Ye, +5 authors, Mira Keyes.
Med Oncol, 2017 Dec 08; 35(1). PMID: 29214466
Recent Trends in Chemotherapy Use and Oncologists' Treatment Recommendations for Early-Stage Breast Cancer.
Allison W Kurian, Irina Bondarenko, +7 authors, Steven J Katz.
J Natl Cancer Inst, 2017 Dec 14; 110(5). PMID: 29237009    Free PMC article.
Enrichment of high-grade tumors in breast cancer gene expression studies.
M van Seijen, A L Mooyaart, +7 authors, E H Lips.
Breast Cancer Res Treat, 2017 Dec 20; 168(2). PMID: 29256013    Free PMC article.
A prognostic signature based on three-genes expression in triple-negative breast tumours with residual disease.
Joseph A Pinto, Jhajaira Araujo, +5 authors, Henry L Gomez.
NPJ Genom Med, 2016 Feb 03; 1. PMID: 29263808    Free PMC article.
Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
R Colomer, I Aranda-López, +7 authors, J Palacios-Calvo.
Clin Transl Oncol, 2017 Dec 24; 20(7). PMID: 29273958    Free PMC article.
Review.
Tumor Heterogeneity in Breast Cancer.
Gulisa Turashvili, Edi Brogi.
Front Med (Lausanne), 2017 Dec 26; 4. PMID: 29276709    Free PMC article.
Highly Cited. Review.
The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer.
Satbir Singh Thakur, Haocheng Li, +5 authors, Hua Yang.
PLoS One, 2018 Jan 06; 13(1). PMID: 29304138    Free PMC article.
Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up.
Gulisa Turashvili, Edi Brogi, +4 authors, Hannah Y Wen.
BMC Cancer, 2018 Jan 07; 18(1). PMID: 29304773    Free PMC article.
Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome.
Christos Davatzikos, Saima Rathore, +22 authors, Despina Kontos.
J Med Imaging (Bellingham), 2018 Jan 18; 5(1). PMID: 29340286    Free PMC article.
Highly Cited.
Luminal-like HER2-negative stage IA breast cancer: a multicenter retrospective study on long-term outcome with propensity score analysis.
Carmine De Angelis, Massimo Di Maio, +12 authors, Grazia Arpino.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348868    Free PMC article.
Impact of chemotherapy relative dose intensity on cause-specific and overall survival for stage I-III breast cancer: ER+/PR+, HER2- vs. triple-negative.
Lu Zhang, Qingzhao Yu, +5 authors, Tekeda Ferguson.
Breast Cancer Res Treat, 2018 Jan 26; 169(1). PMID: 29368311    Free PMC article.
Prospective Evaluation of the Impact of the 21-Gene Recurrence Score Assay on Adjuvant Treatment Decisions for Women with Node-Positive Breast Cancer in Ontario, Canada.
Sofia Torres, Maureen Trudeau, +7 authors, Andrea Eisen.
Oncologist, 2018 Jan 27; 23(7). PMID: 29371476    Free PMC article.
Prediction of low-risk breast cancer using quantitative DCE-MRI and its pathological basis.
Tingting Xu, Lin Zhang, +5 authors, Guangyu Tang.
Oncotarget, 2018 Jan 27; 8(69). PMID: 29371992    Free PMC article.
A study of association of Oncotype DX recurrence score with DCE-MRI characteristics using multivariate machine learning models.
Ashirbani Saha, Michael R Harowicz, Weiyao Wang, Maciej A Mazurowski.
J Cancer Res Clin Oncol, 2018 Feb 11; 144(5). PMID: 29427210    Free PMC article.
Prognostic significance of heparanase expression in primary and metastatic breast carcinoma.
Olga Vornicova, Inna Naroditsky, +5 authors, Gil Bar-Sela.
Oncotarget, 2018 Feb 22; 9(5). PMID: 29464068    Free PMC article.
Breast cancer-specific survival by age: Worse outcomes for the oldest patients.
Rachel A Freedman, Nancy L Keating, +5 authors, William T Barry.
Cancer, 2018 Mar 03; 124(10). PMID: 29499074    Free PMC article.
Spotlight on the utility of the Oncotype DX® breast cancer assay.
Zhen Rong Siow, Richard H De Boer, Geoffrey J Lindeman, G Bruce Mann.
Int J Womens Health, 2018 Mar 06; 10. PMID: 29503586    Free PMC article.
Review.
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer.
Onur Esbah, Berna Oksuzoglu.
Indian J Med Res, 2018 Mar 08; 146(5). PMID: 29512598    Free PMC article.
Review.
The 21-Gene Recurrence Score in Male Breast Cancer.
Gulisa Turashvili, Monica Gonzalez-Loperena, +4 authors, Hannah Y Wen.
Ann Surg Oncol, 2018 Mar 10; 25(6). PMID: 29520654    Free PMC article.
Validation of Memorial Sloan Kettering Cancer Center nomogram to detect non-sentinel lymph node metastases in a United Kingdom cohort.
A Syed, S Eleti, +2 authors, H Thomas.
G Chir, 2018 Mar 20; 39(1). PMID: 29549676    Free PMC article.
Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer.
Sung Gwe Ahn, Yoon Jin Cha, +3 authors, Joon Jeong.
BMC Cancer, 2018 Mar 27; 18(1). PMID: 29573739    Free PMC article.
Molecular Characterization and Mortality From Breast Cancer in Men.
Suleiman Alfred Massarweh, George W Sledge, +3 authors, Steven Shak.
J Clin Oncol, 2018 Mar 28; 36(14). PMID: 29584547    Free PMC article.
Clinical and economic impact of the 21-gene recurrence score assay in adjuvant therapy decision making in patients with early-stage breast cancer: pooled analysis in 4 Basque Country university hospitals.
Purificación Martínez Del Prado, Isabel Alvarez-López, +7 authors, Javier Mar.
Clinicoecon Outcomes Res, 2018 Mar 30; 10. PMID: 29593426    Free PMC article.
Cost-Effectiveness Analyses of the 21-Gene Assay in Breast Cancer: Systematic Review and Critical Appraisal.
Shi-Yi Wang, Weixiong Dang, +3 authors, Cary P Gross.
J Clin Oncol, 2018 Apr 17; 36(16). PMID: 29659329    Free PMC article.
Systematic Review.
Practice patterns and outcomes for patients with node-negative hormone receptor-positive breast cancer and intermediate 21-gene Recurrence Scores.
Jonathan Chen, Xian Wu, +2 authors, Himanshu Nagar.
Breast Cancer Res, 2018 Apr 18; 20(1). PMID: 29661221    Free PMC article.
Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.
Anne-Laure Renault, Noura Mebirouk, +42 authors, Fabienne Lesueur.
Breast Cancer Res, 2018 Apr 19; 20(1). PMID: 29665859    Free PMC article.
The 21-gene Recurrence Score® assay predicts distant recurrence in lymph node-positive, hormone receptor-positive, breast cancer patients treated with adjuvant sequential epirubicin- and docetaxel-based or epirubicin-based chemotherapy (PACS-01 trial).
Frédérique Penault-Llorca, Thomas Filleron, +12 authors, Henri Roché.
BMC Cancer, 2018 May 08; 18(1). PMID: 29728098    Free PMC article.
Combined pathologic-genomic algorithm for early-stage breast cancer improves cost-effective use of the 21-gene recurrence score assay.
M M Gage, W C Mylander, +9 authors, R S Jackson.
Ann Oncol, 2018 May 23; 29(5). PMID: 29788166    Free PMC article.
Gene expression profiling in prognosis of distant recurrence in HR-positive and HER2-negative breast cancer patients.
Tzu-Ting Huang, Nicolas Pennarun, +3 authors, Skye Hung-Chun Cheng.
Oncotarget, 2018 May 26; 9(33). PMID: 29796180    Free PMC article.
Spinal cord injured women's treatment of breast carcinoma: alert to complications.
Ashley L de Padua, Kimberly Strickland, Mary Patrick, John F Ditunno.
Spinal Cord Ser Cases, 2018 May 31; 4. PMID: 29844929    Free PMC article.
Prognostic gene expression assays in breast cancer: are two better than one?
Joseph A Sparano.
NPJ Breast Cancer, 2018 May 31; 4. PMID: 29845110    Free PMC article.
Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer.
Jon Whitney, German Corredor, +6 authors, Anant Madabhushi.
BMC Cancer, 2018 Jun 01; 18(1). PMID: 29848291    Free PMC article.
Three-lncRNA signature is a potential prognostic biomarker for pancreatic adenocarcinoma.
Xiuhui Shi, Yan Zhao, +8 authors, Renyi Qin.
Oncotarget, 2018 Jun 01; 9(36). PMID: 29849937    Free PMC article.
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2018 Jun 05; 379(2). PMID: 29860917    Free PMC article.
Highly Cited.
A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score.
Feilin Qu, Xiaosong Chen, +10 authors, Kunwei Shen.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861607    Free PMC article.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.
S K L Chia.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655    Free PMC article.
Review.
Verification of a Western Nomogram for Predicting Oncotype DX™ Recurrence Scores in Korean Patients with Breast Cancer.
Jae-Myung Kim, Jai Min Ryu, +6 authors, Jeong Eon Lee.
J Breast Cancer, 2018 Jul 03; 21(2). PMID: 29963119    Free PMC article.
Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology.
Danielle M Bello, Christy Russell, +2 authors, Monica Morrow.
Ann Surg Oncol, 2018 Jul 04; 25(10). PMID: 29968028    Free PMC article.
Gene expression assay and Watson for Oncology for optimization of treatment in ER-positive, HER2-negative breast cancer.
Yun Yeong Kim, Se Jeong Oh, +2 authors, Heung Kyu Park.
PLoS One, 2018 Jul 07; 13(7). PMID: 29979736    Free PMC article.
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
Kamran A Ahmed, G Daniel Grass, +7 authors, Roberto Diaz.
Int J Breast Cancer, 2018 Jul 10; 2018. PMID: 29984003    Free PMC article.
Review.
Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.
W Iris Zhi, Evan Ingram, +3 authors, Ting Bao.
Integr Cancer Ther, 2018 Jul 22; 17(4). PMID: 30027756    Free PMC article.
Development of a Novel Proteomic Risk-Classifier for Prognostication of Patients With Early-Stage Hormone Receptor-Positive Breast Cancer.
Charusheila Ramkumar, Ljubomir Buturovic, +7 authors, Manjiri M Bakre.
Biomark Insights, 2018 Aug 08; 13. PMID: 30083053    Free PMC article.
Breast Cancers of Special Histologic Subtypes Are Biologically Diverse.
Audree B Tadros, Hannah Y Wen, Monica Morrow.
Ann Surg Oncol, 2018 Aug 11; 25(11). PMID: 30094484    Free PMC article.
Overview of Breast Cancer Therapy.
Tracy-Ann Moo, Rachel Sanford, Chau Dang, Monica Morrow.
PET Clin, 2018 Aug 14; 13(3). PMID: 30100074    Free PMC article.
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Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center.
Hans-Ullrich Voelker, Lea Frey, Annette Strehl, Michael Weigel.
Int J Breast Cancer, 2018 Aug 17; 2018. PMID: 30112216    Free PMC article.
SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment.
Yu-Hsiang Huang, Pei-Yi Chu, +8 authors, Chun-Yu Liu.
J Clin Med, 2018 Aug 30; 7(9). PMID: 30154367    Free PMC article.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era.
Eleftherios P Mamounas, Christy A Russell, +2 authors, Kathy S Albain.
NPJ Breast Cancer, 2018 Aug 30; 4. PMID: 30155517    Free PMC article.
Review.
Genomic Testing in the Management of Early-Stage Breast Cancer.
Sima Ehsani, Kari Braun Wisinski.
J Clin Outcomes Manag, 2017 May 01; 24(5). PMID: 30158821    Free PMC article.
Levels of uPA and PAI-1 in breast cancer and its correlation to Ki67-index and results of a 21-multigene-array.
Hans-Ullrich Völker, Michael Weigel, Annette Strehl, Lea Frey.
Diagn Pathol, 2018 Sep 02; 13(1). PMID: 30170623    Free PMC article.
The digital age of melanoma management: detection and diagnostics.
Alexander L Fogel, Kavita Sarin.
Melanoma Manag, 2015 Nov 01; 2(4). PMID: 30190865    Free PMC article.
Review.
RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer-From Cell Line Models to Liquid Biopsies.
Marvin C J Lim, Anne-Marie Baird, +5 authors, Stephen P Finn.
Diagnostics (Basel), 2018 Sep 12; 8(3). PMID: 30200254    Free PMC article.
Review.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study.
Wei Wang, Xiaosong Chen, +12 authors, Kunwei Shen.
J Cancer, 2018 Oct 03; 9(18). PMID: 30271480    Free PMC article.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Combined Performance of Screening and Variable Selection Methods in Ultra-High Dimensional Data in Predicting Time-To-Event Outcomes.
Lira Pi, Susan Halabi.
Diagn Progn Res, 2018 Nov 06; 2. PMID: 30393771    Free PMC article.
21-Gene assay as predictor of chemotherapy benefit in HER2-negative breast cancer.
Charles E Geyer, Gong Tang, +8 authors, Norman Wolmark.
NPJ Breast Cancer, 2018 Nov 21; 4. PMID: 30456299    Free PMC article.
Microfluidics: Rapid Diagnosis for Breast Cancer.
Satvinder Panesar, Suresh Neethirajan.
Nanomicro Lett, 2016 Jan 01; 8(3). PMID: 30460281    Free PMC article.
Review.
BCT score predicts chemotherapy benefit in Asian patients with hormone receptor-positive, HER2-negative, lymph node-negative breast cancer.
Mi Jeong Kwon, Sae Byul Lee, +8 authors, Young Kee Shin.
PLoS One, 2018 Nov 22; 13(11). PMID: 30462685    Free PMC article.
The Warwick Experience of the Oncotype DX® Breast Recurrence Score® Assay as a Predictor of Chemotherapy Administration.
Mashuk Alam Khan, Laura Henderson, +2 authors, Lucie Jones.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498424    Free PMC article.
Adjuvant Systemic Treatment of Premenopausal Women With Hormone Receptor-Positive Early Breast Cancer: Lights and Shadows.
Meredith M Regan, Gini F Fleming, +2 authors, Olivia Pagani.
J Clin Oncol, 2019 Feb 28; 37(11). PMID: 30811287    Free PMC article.
Impact of 21-Gene Recurrence Score on Chemotherapy Decision in Invasive Ductal Carcinoma of Breast with Nodal Micrometastases.
Wei-Rong Chen, Jia-Peng Deng, +3 authors, San-Gang Wu.
Cancer Res Treat, 2019 Mar 28; 51(4). PMID: 30913871    Free PMC article.
Evaluation of the Incorporation of Recurrence Score into the American Joint Committee on Cancer Eighth Edition Staging System in Patients with T1-2N0M0, Estrogen Receptor-Positive, Human Epidermal Growth Receptor 2-Negative Invasive Breast Cancer: A Population-Based Analysis.
Shuning Ding, Jiayi Wu, +6 authors, Li Zhu.
Oncologist, 2019 Apr 26; 24(11). PMID: 31019021    Free PMC article.
From latency to overt bone metastasis in breast cancer: potential for treatment and prevention.
Fernando Salvador, Alicia Llorente, Roger R Gomis.
J Pathol, 2019 May 17; 249(1). PMID: 31095738    Free PMC article.
Review.
The Pros and Cons of Incorporating Transcriptomics in the Age of Precision Oncology.
Victor T G Lin, Eddy S Yang.
J Natl Cancer Inst, 2019 Jun 06; 111(10). PMID: 31165154    Free PMC article.
Review.
The effect of Oncotype DX® on adjuvant chemotherapy treatment decisions in early breast cancer.
M A Rabie, A Rankin, A Burger, Mmg Youssef.
Ann R Coll Surg Engl, 2019 Jun 21; 101(8). PMID: 31219316    Free PMC article.
Diffusion-weighted MRI of estrogen receptor-positive, HER2-negative, node-negative breast cancer: association between intratumoral heterogeneity and recurrence risk.
Jin You Kim, Jin Joo Kim, +8 authors, Robert Grimm.
Eur Radiol, 2019 Aug 07; 30(1). PMID: 31385051
Artificial intelligence in digital pathology - new tools for diagnosis and precision oncology.
Kaustav Bera, Kurt A Schalper, +2 authors, Anant Madabhushi.
Nat Rev Clin Oncol, 2019 Aug 11; 16(11). PMID: 31399699    Free PMC article.
Highly Cited. Review.
Panoptic View of Prognostic Models for Personalized Breast Cancer Management.
Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225    Free PMC article.
Review.
Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer.
Tanja Ovcaricek, Iztok Takac, Erika Matos.
Radiol Oncol, 2019 Sep 26; 53(3). PMID: 31553709    Free PMC article.
Review.
Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial.
Joseph A Sparano, Robert J Gray, +26 authors, George W Sledge.
JAMA Oncol, 2019 Oct 01; 6(3). PMID: 31566680    Free PMC article.
21-Gene recurrence score influences the chemotherapy decision for patients with breast cancer of different luminal subtypes.
Wei Wang, Lin Lin, +11 authors, Kunwei Shen.
Oncol Lett, 2019 Oct 04; 18(4). PMID: 31579428    Free PMC article.
GSIAR: gene-subcategory interaction-based improved deep representation learning for breast cancer subcategorical analysis using gene expression, applicable for precision medicine.
Chiranjib Sur.
Med Biol Eng Comput, 2019 Oct 09; 57(11). PMID: 31591679
Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30.
Seho Park, Yunan Han, +7 authors, Yikyung Park.
Breast Cancer Res, 2019 Oct 18; 21(1). PMID: 31619259    Free PMC article.
Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959).
Di Dong, Fan Zhang, +7 authors, Ling-Long Tang.
BMC Med, 2019 Oct 24; 17(1). PMID: 31640711    Free PMC article.
Impact of the 21-gene recurrence score assay on chemotherapy decision making and outcomes for breast cancer patients with four or more positive lymph nodes.
Qing-Hong Zhang, Wen-Wen Zhang, +4 authors, San-Gang Wu.
Ann Transl Med, 2019 Nov 09; 7(18). PMID: 31700882    Free PMC article.
Germline variants associated with leukocyte genes predict tumor recurrence in breast cancer patients.
Jean-Sébastien Milanese, Chabane Tibiche, +5 authors, Edwin Wang.
NPJ Precis Oncol, 2019 Nov 09; 3. PMID: 31701019    Free PMC article.
Ten-year clinical outcomes in N0 ER+ breast cancer patients with Recurrence Score-guided therapy.
Salomon M Stemmer, Mariana Steiner, +16 authors, David B Geffen.
NPJ Breast Cancer, 2019 Nov 16; 5. PMID: 31728408    Free PMC article.
A Nomogram To Predict The Overall Survival Of Breast Cancer Patients And Guide The Postoperative Adjuvant Chemotherapy In China.
Xin Wang, Ziwei Feng, +12 authors, Kexin Chen.
Cancer Manag Res, 2019 Dec 11; 11. PMID: 31819635    Free PMC article.
Genetic determinants of the molecular portraits of epithelial cancers.
Youli Xia, Cheng Fan, +2 authors, Charles M Perou.
Nat Commun, 2019 Dec 13; 10(1). PMID: 31827079    Free PMC article.
Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help?
Marie Alexandre, Aurélie Maran-Gonzalez, +6 authors, Séverine Guiu.
Cancer Manag Res, 2019 Dec 19; 11. PMID: 31849525    Free PMC article.
Review.
Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice.
Douglas Grossman, Caroline C Kim, +6 authors, Susan M Swetter.
Melanoma Manag, 2019 Dec 25; 6(4). PMID: 31871621    Free PMC article.
Review.
In Silico Approach for the Definition of radiomiRNomic Signatures for Breast Cancer Differential Diagnosis.
Francesca Gallivanone, Claudia Cava, +2 authors, Isabella Castiglioni.
Int J Mol Sci, 2019 Nov 24; 20(23). PMID: 31756987    Free PMC article.
Omission of Chemotherapy for the Treatment of Mucinous Breast Cancer: A Nationwide Study from the Korean Breast Cancer Society.
Hyung Suk Kim, Jong Uk Lee, +4 authors, Woo Chan Park.
J Breast Cancer, 2020 Jan 04; 22(4). PMID: 31897333    Free PMC article.
Evaluation of Prognosis in Hormone Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancer With Low Oncotype DX Recurrence Score.
Jane Meisel, Chao Zhang, +7 authors, Xiaoxian Li.
Clin Breast Cancer, 2018 Jan 07; 18(5). PMID: 29305309    Free PMC article.
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Yu-Jin Kim, Gyunghwa Lee, +4 authors, Young Kee Shin.
Front Oncol, 2020 Feb 11; 9. PMID: 32039034    Free PMC article.
Development of an Immune-Related Prognostic Signature in Breast Cancer.
Peiling Xie, Yuying Ma, +3 authors, Huimin Zhang.
Front Genet, 2020 Feb 13; 10. PMID: 32047513    Free PMC article.
Comparison of 21-gene assay and St.Gallen International Expert Consensus in the treatment decision for patients with early invasive breast cancers.
Ming Luo, Fu Li, +2 authors, Jian Zeng.
Cancer Biol Ther, 2019 Oct 31; 21(2). PMID: 31663437    Free PMC article.
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer.
Joseph A Sparano, Robert J Gray, +27 authors, George W Sledge.
N Engl J Med, 2019 Jun 04; 380(25). PMID: 31157962    Free PMC article.
Highly Cited.
miRNAs and Long-term Breast Cancer Survival: Evidence from the WHEL Study.
Loki Natarajan, Minya Pu, +10 authors, Karen Messer.
Cancer Epidemiol Biomarkers Prev, 2019 Jun 13; 28(9). PMID: 31186261    Free PMC article.
Prognostic Impact of the 21-Gene Recurrence Score Assay Among Young Women With Node-Negative and Node-Positive ER-Positive/HER2-Negative Breast Cancer.
Philip D Poorvu, Shari I Gelber, +12 authors, Ann H Partridge.
J Clin Oncol, 2019 Dec 07; 38(7). PMID: 31809240    Free PMC article.
MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer.
Begoña Alday-Parejo, François Richard, +5 authors, Curzio Rüegg.
Cancers (Basel), 2020 Jan 23; 12(1). PMID: 31963297    Free PMC article.
Indications for prognostic gene expression profiling in early breast cancer.
Erin F Cobain, Daniel F Hayes.
Curr Treat Options Oncol, 2015 May 02; 16(5). PMID: 25929335
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21-Gene Recurrence Score and Adjuvant Chemotherapy Decision for Breast Cancer Patients with Positive Lymph Nodes.
Yiwei Tong, Jiayi Wu, +6 authors, Kunwei Shen.
Sci Rep, 2019 Sep 13; 9(1). PMID: 31511599    Free PMC article.
Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer.
Andreana N Holowatyj, Michele L Cote, +5 authors, Kristen S Purrington.
J Clin Oncol, 2018 Jan 18; 36(7). PMID: 29341832    Free PMC article.
The Prosigna 50-gene profile and responsiveness to adjuvant anthracycline-based chemotherapy in high-risk breast cancer patients.
Maj-Britt Jensen, Anne-Vibeke Lænkholm, +9 authors, Bent Ejlertsen.
NPJ Breast Cancer, 2020 Mar 07; 6. PMID: 32140564    Free PMC article.
Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.
Kelsey H Natsuhara, Katya Losk, +7 authors, Rachel A Freedman.
Oncologist, 2018 Aug 05; 24(5). PMID: 30076279    Free PMC article.
Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy?
Abiola F Ibraheem, David J Press, Olufunmilayo I Olopade, Dezheng Huo.
Cancer, 2018 Nov 06; 125(2). PMID: 30387876    Free PMC article.
Lymph node involvement: Positive about the role of the recurrence score in estrogen-driven breast cancer?
Kevin Kalinsky, Ruth M O'Regan.
Cancer, 2018 Nov 06; 125(2). PMID: 30387877    Free PMC article.
Breast Cancers With Magee Equation Score of Less Than 18, or 18-25 and Mitosis Score of 1, Do Not Require Oncotype DX Testing: A Value Study.
Rohit Bhargava, Beth Z Clark, David J Dabbs.
Am J Clin Pathol, 2018 Nov 06; 151(3). PMID: 30395177    Free PMC article.
Kinetic Features of Invasive Breast Cancers on Computer-Aided Diagnosis Using 3T MRI Data: Correlation with Clinical and Pathologic Prognostic Factors.
Sung Eun Song, Kyu Ran Cho, +3 authors, Deuk Jae Sung.
Korean J Radiol, 2019 Feb 26; 20(3). PMID: 30799572    Free PMC article.
SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment.
Tarek M A Abdel-Fatah, Reuben J Broom, +20 authors, Dong-Xu Liu.
Br J Cancer, 2019 Mar 01; 120(7). PMID: 30816325    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
Oncotype DX: Where Does It Stand in India?
Atul Batra, Amol Patel, +6 authors, Priyanka Srivastava.
J Glob Oncol, 2019 Jul 17; 5. PMID: 31310569    Free PMC article.
A Multigene Assay Determines Risk of Recurrence in Patients with Triple-Negative Breast Cancer.
Rachel L Stewart, Katherine L Updike, +4 authors, Katherine E Varley.
Cancer Res, 2019 May 03; 79(13). PMID: 31048497    Free PMC article.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
The impact of Oncotype DX breast cancer assay results on clinical practice: a UK experience.
Valerie E Crolley, Husam Marashi, +12 authors, Judy King.
Breast Cancer Res Treat, 2020 Mar 15; 180(3). PMID: 32170635    Free PMC article.
PRDX4 overexpression is associated with poor prognosis in gastric cancer.
Sun Yi Park, Young-Joon Lee, +11 authors, Sang-Ho Jeong.
Oncol Lett, 2020 Apr 10; 19(5). PMID: 32269626    Free PMC article.
Gene Expression Profiling Tests for Early-Stage Invasive Breast Cancer: A Health Technology Assessment.
Ontario Health (Quality).
Ont Health Technol Assess Ser, 2020 Apr 15; 20(10). PMID: 32284770    Free PMC article.
The Correlation of Magee EquationsTM and Oncotype DX® Recurrence Score From Core Needle Biopsy Tissues in Predicting Response to Neoadjuvant Chemotherapy in ER+ and HER2- Breast Cancer.
Atilla Soran, Kaori Tane, Efe Sezgin, Rohit Bhargava.
Eur J Breast Health, 2020 Apr 15; 16(2). PMID: 32285033    Free PMC article.
Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX® recurrence score <26.
Bradley M Turner, Mary Ann Gimenez-Sanders, +6 authors, David G Hicks.
Cancer Med, 2019 Jun 15; 8(9). PMID: 31199586    Free PMC article.
Ki-67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive cohort study.
Yanna Zhang, Yidong Zhou, +2 authors, Qiang Sun.
Cancer Commun (Lond), 2020 Apr 16; 40(4). PMID: 32291973    Free PMC article.
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Epidemiology, 2020 Feb 25; 31(3). PMID: 32091429    Free PMC article.
Simulation Modeling to Extend Clinical Trials of Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Early Breast Cancer.
Jinani Jayasekera, Joseph A Sparano, +5 authors, Jeanne Mandelblatt.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337487    Free PMC article.
Association of Adjuvant Chemotherapy With Overall Survival in Patients With Early-Stage Breast Cancer and 21-Gene Recurrence Scores of 26 or Higher.
Sung Jun Ma, Oluwadamilola T Oladeru, Anurag K Singh.
JAMA Netw Open, 2020 May 05; 3(5). PMID: 32364592    Free PMC article.
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Ying Liu, Robert West, Jason D Weber, Graham A Colditz.
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Tamoxifen Metabolism and Breast Cancer Recurrence: A Question Unanswered by CYPTAM.
Matthew P Goetz, Vera J Suman, +3 authors, James N Ingle.
J Clin Oncol, 2019 Jun 19; 37(22). PMID: 31211604    Free PMC article.
Chromatin regulators mediate anthracycline sensitivity in breast cancer.
Jose A Seoane, Jacob G Kirkland, +2 authors, Christina Curtis.
Nat Med, 2019 Nov 09; 25(11). PMID: 31700186    Free PMC article.
21-Gene Recurrence Score Adds Significant Value for Grade 3 Breast Cancers: Results From a National Cohort.
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JCO Precis Oncol, 2019 Jan 01; 3. PMID: 32457931    Free PMC article.
Do 21-Gene Recurrence Score Influence Chemotherapy Decisions in T1bN0 Breast Cancer Patients?
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
Front Oncol, 2020 Jun 02; 10. PMID: 32477946    Free PMC article.
Impact of Recurrence Score on type and duration of chemotherapy in breast cancer.
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Curr Oncol, 2020 Jun 04; 27(2). PMID: 32489257    Free PMC article.
Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia.
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World J Surg Oncol, 2020 Jun 01; 18(1). PMID: 32473643    Free PMC article.
DGM-CM6: A New Model to Predict Distant Recurrence Risk in Operable Endocrine-Responsive Breast Cancer.
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Front Oncol, 2020 Jun 13; 10. PMID: 32528885    Free PMC article.
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Br J Cancer, 2020 Apr 09; 122(12). PMID: 32265507    Free PMC article.
Radiogenomics of magnetic resonance imaging and a new multi-gene classifier for predicting recurrence prognosis in estrogen receptor-positive breast cancer: A preliminary study.
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Medicine (Baltimore), 2020 Apr 22; 99(16). PMID: 32311939    Free PMC article.
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Breast Cancer Res Treat, 2020 May 21; 182(1). PMID: 32430679    Free PMC article.
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J Natl Cancer Inst, 2019 Oct 16; 112(6). PMID: 31612212    Free PMC article.
Does Mode of Surgical Intervention Based on Oncotype DX Score Influence Disease Recurrence in Early Breast Cancer?
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J Breast Cancer, 2020 Jul 01; 23(3). PMID: 32595988    Free PMC article.
The concordance of treatment decision guided by OncotypeDX and the PREDICT tool in real-world early-stage breast cancer.
Daniel A Goldstein, Chen Mayer, +5 authors, Hadar Goldvaser.
Cancer Med, 2020 May 07; 9(13). PMID: 32372569    Free PMC article.
A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management.
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Value Health, 2019 Sep 30; 22(10). PMID: 31563252    Free PMC article.
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JAMA Netw Open, 2020 Jul 10; 3(7). PMID: 32644137    Free PMC article.
Features, Outcomes, and Management Strategies of Male Breast Cancer: A Single Institution Comparison to Well-Matched Female Controls.
Joseph Liu, Anupama Suresh, +18 authors, Robert Wesolowski.
Eur J Breast Health, 2020 Jul 14; 16(3). PMID: 32656521    Free PMC article.
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Sex Disparity Observed for Oncotype DX Breast Recurrence Score in Predicting Mortality Among Patients with Early Stage ER-Positive Breast Cancer.
Fei Wang, Sonya Reid, +6 authors, Xiao-Ou Shu.
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The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.
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Adjuvant chemotherapy for node negative, high Recurrence ScoreTM breast cancer: in defense of de-escalation.
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NPJ Breast Cancer, 2019 Aug 21; 5. PMID: 31428677    Free PMC article.
Prospective observational study on the impact of the 21-gene assay on treatment decisions and resources optimization in breast cancer patients in Lombardy: The BONDX study.
Alberto Zambelli, Edda Simoncini, +11 authors, Carlo Tondini.
Breast, 2020 Apr 24; 52. PMID: 32325372    Free PMC article.
A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry.
Barbara L Smith, Anvy Nguyen, +6 authors, Michele A Gadd.
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Comparison of the Distribution Pattern of 21-Gene Recurrence Score between Mucinous Breast Cancer and Infiltrating Ductal Carcinoma in Chinese Population: A Retrospective Single-Center Study.
Jiayi Wu, Shuning Ding, +16 authors, Li Zhu.
Cancer Res Treat, 2020 Feb 06; 52(3). PMID: 32019280    Free PMC article.
Clinicopathological characteristics, adjuvant chemotherapy decision and disease outcome in patients with breast cancer with a 21-gene recurrence score of 26-30.
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Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724396    Free PMC article.
The healthcare value of the Magee Decision Algorithm™: use of Magee Equations™ and mitosis score to safely forgo molecular testing in breast cancer.
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Mod Pathol, 2020 Mar 24; 33(8). PMID: 32203092    Free PMC article.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.
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Association between the 21-gene recurrence score and isolated locoregional recurrence in stage I-II, hormone receptor-positive breast cancer.
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Discordance in 21-gene recurrence scores between paired breast cancer samples is inversely associated with patient age.
Sarah M Bernhardt, Pallave Dasari, +6 authors, Wendy V Ingman.
Breast Cancer Res, 2020 Aug 20; 22(1). PMID: 32811558    Free PMC article.
Primary 21-Gene Recurrence Score and Disease Outcome in Loco-Regional and Distant Recurrent Breast Cancer Patients.
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Front Oncol, 2020 Aug 28; 10. PMID: 32850415    Free PMC article.
Genomic comparison of paired primary breast carcinomas and lymph node macrometastases using the Oncotype DX Breast Recurrence Score® test.
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Breast Cancer Res Treat, 2019 Jul 16; 177(3). PMID: 31302854    Free PMC article.
Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes.
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Mol Cancer Res, 2020 Jun 11; 18(9). PMID: 32518213    Free PMC article.
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PLoS One, 2020 Sep 04; 15(9). PMID: 32881987    Free PMC article.
Predicting Expected Absolute Chemotherapy Treatment Benefit in Women With Early-Stage Breast Cancer Using EndoPredict, an Integrated 12-Gene Clinicomolecular Assay.
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JCO Precis Oncol, 2020 Sep 12; 3. PMID: 32914026    Free PMC article.
BCL-2 expression aids in the immunohistochemical prediction of the Oncotype DX breast cancer recurrence score.
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The Distribution and Outcomes of the 21-Gene Recurrence Score in T1-T2N0 Estrogen Receptor-Positive Breast Cancer With Different Histologic Subtypes.
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Front Genet, 2019 Jan 09; 9. PMID: 30619463    Free PMC article.
Ki-67 index value and progesterone receptor status can predict prognosis and suitable treatment in node-negative breast cancer patients with estrogen receptor-positive and HER2-negative tumors.
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Examination of the Biomark assay as an alternative to Oncotype DX for defining chemotherapy benefit.
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Oncol Lett, 2019 Jan 25; 17(2). PMID: 30675242    Free PMC article.
21-Gene Recurrence Score Assay and Outcomes of Adjuvant Radiotherapy in Elderly Women With Early-Stage Breast Cancer After Breast-Conserving Surgery.
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Front Oncol, 2019 Feb 15; 9. PMID: 30761267    Free PMC article.
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A novel LARCassigner3 classification predicts outcomes in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy: a retrospective training and validation analysis.
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Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
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Relationship Study of The Verified H uman Epidermal Growth Factor Receptor 2 Amplification with Other Tumor Markers and Clinicohistopathological Characteristics in Patients with Invasive Breast Cancer, Using Chromogenic In Situ Hybridization.
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Cost effectiveness of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in a Middle-Income Country, Turkey: Results of a Prospective Multicenter Study.
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Eur J Breast Health, 2019 Jul 18; 15(3). PMID: 31312795    Free PMC article.
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Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
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Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
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Adjuvant chemotherapy could benefit early-stage ER/PR positive mucinous breast cancer: A SEER-based analysis.
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Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
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Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010-2016.
Thomas M Schwedhelm, Judy R Rees, +4 authors, Erika L Moen.
BMC Cancer, 2020 Sep 05; 20(1). PMID: 32883270    Free PMC article.
Cole Relaxation Frequency as a Prognostic Parameter for Breast Cancer.
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Racial and ethnic disparities in 21-gene recurrence scores, chemotherapy, and survival among women with hormone receptor-positive, node-negative breast cancer.
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Radiomics signature on 3T dynamic contrast-enhanced magnetic resonance imaging for estrogen receptor-positive invasive breast cancers: Preliminary results for correlation with Oncotype DX recurrence scores.
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A multiple breast cancer stem cell model to predict recurrence of T1-3, N0 breast cancer.
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BMC Cancer, 2019 Jul 26; 19(1). PMID: 31340763    Free PMC article.
Is Routine Recurrence Score Testing in Patients Older than 70 Years of Age Warranted? An Evaluation of the National Cancer Database After TAILORx.
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A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients.
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Degree of Early Estrogen Response Predict Survival after Endocrine Therapy in Primary and Metastatic ER-Positive Breast Cancer.
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A novel immune prognostic index for stratification of high-risk patients with early breast cancer.
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The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer.
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Factors That Predict Biological Aggressiveness in Estrogen Receptor-Positive / Human Epidermal Growth Factor Receptor 2-Negative / Lymph Node-Negative Breast Cancer.
Lauren E Arthur, Ashley H McMann, +4 authors, Ralph L Corsetti.
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Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients.
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Adjuvant Chemotherapy for Patients with Breast Cancer Based on Clinical and Evolving Oncotype DX Criteria.
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Immune Cell-Associated Protein Expression Helps to Predict Survival in Muscle-Invasive Urothelial Bladder Cancer Patients after Radical Cystectomy and Optional Adjuvant Chemotherapy.
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Oncotype DX testing in node-positive breast cancer strongly impacts chemotherapy use at a comprehensive cancer center.
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A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling.
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A nomogram to predict the high-risk RS in HR+/HER2-breast cancer patients older than 50 years of age.
Jing Yu, Jiayi Wu, +6 authors, Kunwei Shen.
J Transl Med, 2021 Feb 18; 19(1). PMID: 33593381    Free PMC article.
Background Parenchymal Enhancement on Breast MRI as a Prognostic Surrogate: Correlation With Breast Cancer Oncotype Dx Score.
Michelle Zhang, Meredith Sadinski, +5 authors, Elizabeth J Sutton.
Front Oncol, 2021 Feb 23; 10. PMID: 33614481    Free PMC article.