Journal Article
. 2006 Aug;355(6).
doi: 10.1056/NEJMoa052933.

Concordance among gene-expression-based predictors for breast cancer

Cheng Fan 1 Daniel S Oh  Lodewyk Wessels  Britta Weigelt  Dimitry S A Nuyten  Andrew B Nobel  Laura J van't Veer  Charles M Perou  
Affiliations
  • PMID: 16899776
  •     446 citations

Abstract

Background: Gene-expression-profiling studies of primary breast tumors performed by different laboratories have resulted in the identification of a number of distinct prognostic profiles, or gene sets, with little overlap in terms of gene identity.

Methods: To compare the predictions derived from these gene sets for individual samples, we obtained a single data set of 295 samples and applied five gene-expression-based models: intrinsic subtypes, 70-gene profile, wound response, recurrence score, and the two-gene ratio (for patients who had been treated with tamoxifen).

Results: We found that most models had high rates of concordance in their outcome predictions for the individual samples. In particular, almost all tumors identified as having an intrinsic subtype of basal-like, HER2-positive and estrogen-receptor-negative, or luminal B (associated with a poor prognosis) were also classified as having a poor 70-gene profile, activated wound response, and high recurrence score. The 70-gene and recurrence-score models, which are beginning to be used in the clinical setting, showed 77 to 81 percent agreement in outcome classification.

Conclusions: Even though different gene sets were used for prognostication in patients with breast cancer, four of the five tested showed significant agreement in the outcome predictions for individual patients and are probably tracking a common set of biologic phenotypes.

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Cancer Genet Cytogenet, 2009 Jul 16; 193(1). PMID: 19602461    Free PMC article.
Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer.
Steven Buechler.
BMC Cancer, 2009 Jul 22; 9. PMID: 19619298    Free PMC article.
Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair.
Jean-Christophe Marine, Geert Berx.
Breast Cancer Res, 2009 Aug 12; 11(4). PMID: 19664188    Free PMC article.
Convergent Random Forest predictor: methodology for predicting drug response from genome-scale data applied to anti-TNF response.
Jadwiga R Bienkowska, Gul S Dalgin, +4 authors, John P Carulli.
Genomics, 2009 Aug 25; 94(6). PMID: 19699293    Free PMC article.
Biological determinants of endocrine resistance in breast cancer.
Elizabeth A Musgrove, Robert L Sutherland.
Nat Rev Cancer, 2009 Aug 25; 9(9). PMID: 19701242
Highly Cited. Review.
Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer.
Dezheng Huo, Francis Ikpatt, +15 authors, Olufunmilayo I Olopade.
J Clin Oncol, 2009 Aug 26; 27(27). PMID: 19704069    Free PMC article.
Highly Cited.
Genetic characterization of breast cancer and implications for clinical management.
Felipe C Geyer, Maria A Lopez-Garcia, Maryou B Lambros, Jorge S Reis-Filho.
J Cell Mol Med, 2009 Sep 17; 13(10). PMID: 19754664    Free PMC article.
Review.
Preinvasive breast cancer.
Dennis C Sgroi.
Annu Rev Pathol, 2009 Oct 15; 5. PMID: 19824828    Free PMC article.
Review.
Can survival prediction be improved by merging gene expression data sets?
Haleh Yasrebi, Peter Sperisen, Viviane Praz, Philipp Bucher.
PLoS One, 2009 Oct 24; 4(10). PMID: 19851466    Free PMC article.
Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions.
Celina G Kleer.
Arch Pathol Lab Med, 2009 Nov 06; 133(11). PMID: 19886718    Free PMC article.
Activation of host wound responses in breast cancer microenvironment.
Melissa A Troester, Myung Hee Lee, +7 authors, Sallie Smith Schneider.
Clin Cancer Res, 2009 Nov 06; 15(22). PMID: 19887484    Free PMC article.
Similar expression profiles of a core of genes and proteins in cells that have acquired a metastatic phenotype, genetically or by in vivo evolution.
Laila Illán Rubio, Bertrand Tavitian, Elina Zueva.
Clin Exp Metastasis, 2009 Nov 12; 27(6). PMID: 19904617
GeneSigDB--a curated database of gene expression signatures.
Aedín C Culhane, Thomas Schwarzl, +8 authors, John Quackenbush.
Nucleic Acids Res, 2009 Nov 26; 38(Database issue). PMID: 19934259    Free PMC article.
Histological and molecular types of breast cancer: is there a unifying taxonomy?
Britta Weigelt, Jorge S Reis-Filho.
Nat Rev Clin Oncol, 2009 Nov 28; 6(12). PMID: 19942925
Highly Cited. Review.
Increased H2O2 level in exhaled breath condensate in primary breast cancer patients.
Robert A Stolarek, Elzbieta Potargowicz, +4 authors, Dariusz Nowak.
J Cancer Res Clin Oncol, 2009 Dec 08; 136(6). PMID: 19967414
A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy.
Yiing Lin, Shin Lin, +6 authors, Rebecca L Aft.
Breast Cancer Res Treat, 2009 Dec 08; 123(3). PMID: 19967557    Free PMC article.
Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer.
Philippe L Bedard, Angelo Di Leo, Martine J Piccart-Gebhart.
Nat Rev Clin Oncol, 2009 Dec 10; 7(1). PMID: 19997076
Review.
Effect of training-sample size and classification difficulty on the accuracy of genomic predictors.
Vlad Popovici, Weijie Chen, +15 authors, Lajos Pusztai.
Breast Cancer Res, 2010 Jan 13; 12(1). PMID: 20064235    Free PMC article.
Molecular-based tumour subtypes of canine mammary carcinomas assessed by immunohistochemistry.
Francesco Sassi, Cinzia Benazzi, Gastone Castellani, Giuseppe Sarli.
BMC Vet Res, 2010 Jan 30; 6. PMID: 20109214    Free PMC article.
Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group.
Elai Davicioni, James R Anderson, +2 authors, Timothy J Triche.
J Clin Oncol, 2010 Feb 04; 28(7). PMID: 20124188    Free PMC article.
A population-based gene signature is predictive of breast cancer survival and chemoresponse.
Shruti Rathnagiriswaran, Ying-Wooi Wan, +3 authors, Nancy L Guo.
Int J Oncol, 2010 Feb 04; 36(3). PMID: 20126981    Free PMC article.
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Anita Wolfer, Ben S Wittner, +14 authors, Sridhar Ramaswamy.
Proc Natl Acad Sci U S A, 2010 Feb 06; 107(8). PMID: 20133671    Free PMC article.
Have the roles of two functional polymorphisms in breast cancer, R72P in P53 and MDM2-309 in MDM2, become clearer?
Rodney J Scott.
Breast Cancer Res, 2010 Feb 17; 12(1). PMID: 20156327    Free PMC article.
LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer.
Yoon-La Choi, Melanie Bocanegra, +6 authors, Jonathan R Pollack.
Cancer Res, 2010 Mar 11; 70(6). PMID: 20215510    Free PMC article.
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
Chang Hoon Song, So Yeon Park, +4 authors, In Ah Kim.
Breast Cancer Res, 2010 Mar 17; 12(2). PMID: 20226014    Free PMC article.
Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures.
James Chen, Lee Sam, +5 authors, Yves A Lussier.
J Biomed Inform, 2010 Mar 31; 43(3). PMID: 20350617    Free PMC article.
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
Sabine Tejpar, Monica Bertagnolli, +18 authors, Arnaud Roth.
Oncologist, 2010 Mar 31; 15(4). PMID: 20350999    Free PMC article.
Review.
What should physicians look for in evaluating prognostic gene-expression signatures?
Jyothi Subramanian, Richard Simon.
Nat Rev Clin Oncol, 2010 Apr 28; 7(6). PMID: 20421890
Review.
Gene-expression-based prognostic assays for breast cancer.
Chungyeul Kim, Soonmyung Paik.
Nat Rev Clin Oncol, 2010 May 05; 7(6). PMID: 20440284
Review.
Current controversies in the management of breast cancer.
I Tusquets, L García-Estévez, +17 authors, A Lluch.
Clin Transl Oncol, 2010 May 14; 12(4). PMID: 20462837
Review.
Molecular basis for therapy resistance.
Per E Lønning.
Mol Oncol, 2010 May 15; 4(3). PMID: 20466604    Free PMC article.
Review.
Triple-negative breast cancer.
Rupert Bartsch, Reinhard Ziebermayr, Christoph C Zielinski, Guenther G Steger.
Wien Med Wochenschr, 2010 May 18; 160(7-8). PMID: 20473728
Review.
Prediction of breast cancer prognosis using gene set statistics provides signature stability and biological context.
Gad Abraham, Adam Kowalczyk, +2 authors, Justin Zobel.
BMC Bioinformatics, 2010 May 27; 11. PMID: 20500821    Free PMC article.
Prognostic significance of subtype classification for short- and long-term survival in breast cancer: survival time holds the key.
Stefan Ambs.
PLoS Med, 2010 Jun 04; 7(5). PMID: 20520798    Free PMC article.
miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.
G Vetter, A Saumet, +8 authors, E Friederich.
Oncogene, 2010 Jun 15; 29(31). PMID: 20543867    Free PMC article.
An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer.
Iker Sánchez-Navarro, Angelo Gámez-Pozo, +11 authors, Enrique Espinosa.
BMC Cancer, 2010 Jun 30; 10. PMID: 20584321    Free PMC article.
Breast cancer, neoadjuvant chemotherapy and residual disease.
Mariana Chávez-MacGregor, Ana María González-Angulo.
Clin Transl Oncol, 2010 Jul 10; 12(7). PMID: 20615822
Review.
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.
Zhe Jiang, Tao Deng, +8 authors, Eldad Zacksenhaus.
J Clin Invest, 2010 Aug 04; 120(9). PMID: 20679727    Free PMC article.
Genomic index of sensitivity to endocrine therapy for breast cancer.
W Fraser Symmans, Christos Hatzis, +13 authors, Lajos Pusztai.
J Clin Oncol, 2010 Aug 11; 28(27). PMID: 20697068    Free PMC article.
Highly Cited.
Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study.
Shaheenah Dawood, Rong Hu, +5 authors, Rulla M Tamimi.
Breast Cancer Res Treat, 2010 Aug 17; 126(1). PMID: 20711652    Free PMC article.
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.
Guillaume Banneau, Mickaël Guedj, +15 authors, Michel Longy.
Breast Cancer Res, 2010 Aug 18; 12(4). PMID: 20712882    Free PMC article.
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology.
Donal J Brennan, Darran P O'Connor, +2 authors, William M Gallagher.
Nat Rev Cancer, 2010 Aug 20; 10(9). PMID: 20720569
Review.
Breast cancer prognostic classification in the molecular era: the role of histological grade.
Emad A Rakha, Jorge S Reis-Filho, +15 authors, Ian O Ellis.
Breast Cancer Res, 2010 Sep 02; 12(4). PMID: 20804570    Free PMC article.
Highly Cited. Review.
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer.
Aleix Prat, Joel S Parker, +5 authors, Charles M Perou.
Breast Cancer Res, 2010 Sep 04; 12(5). PMID: 20813035    Free PMC article.
Highly Cited.
Analyzing the regulation of metabolic pathways in human breast cancer.
Gunnar Schramm, Eva-Maria Surmann, +4 authors, Rainer König.
BMC Med Genomics, 2010 Sep 14; 3. PMID: 20831783    Free PMC article.
A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer.
Torsten O Nielsen, Joel S Parker, +12 authors, Matthew J Ellis.
Clin Cancer Res, 2010 Sep 15; 16(21). PMID: 20837693    Free PMC article.
Highly Cited.
Gene expression array testing of FFPE archival breast tumor samples: an optimized protocol for WG-DASL sample preparation.
C C Ton, N Vartanian, +9 authors, P L Porter.
Breast Cancer Res Treat, 2010 Sep 16; 125(3). PMID: 20842525    Free PMC article.
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies.
Daniel J Toft, Vincent L Cryns.
Mol Endocrinol, 2010 Sep 24; 25(2). PMID: 20861225    Free PMC article.
Review.
Identification of high-quality cancer prognostic markers and metastasis network modules.
Jie Li, Anne E G Lenferink, +5 authors, Edwin Wang.
Nat Commun, 2010 Oct 27; 1. PMID: 20975711    Free PMC article.
Highly Cited.
Breast cancer in the personal genomics era.
Rachel E Ellsworth, David J Decewicz, Craig D Shriver, Darrell L Ellsworth.
Curr Genomics, 2010 Nov 03; 11(3). PMID: 21037853    Free PMC article.
Systems biology and genomics of breast cancer.
Charles M Perou, Anne-Lise Børresen-Dale.
Cold Spring Harb Perspect Biol, 2010 Nov 05; 3(2). PMID: 21047916    Free PMC article.
Review.
Node-Negative Breast Cancer: Which Patients Should Be Treated?
Marcus Schmidt.
Breast Care (Basel), 2008 Jan 01; 3(4). PMID: 21076603    Free PMC article.
Triple-negative breast cancer: epidemiology and management options.
Shaheenah Dawood.
Drugs, 2010 Nov 18; 70(17). PMID: 21080741
Review.
Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures.
M C Abba, E Lacunza, M Butti, C M Aldaz.
Biomark Insights, 2010 Nov 18; 5. PMID: 21082037    Free PMC article.
Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups.
Allison W Kurian, Kari Fish, Sarah J Shema, Christina A Clarke.
Breast Cancer Res, 2010 Nov 26; 12(6). PMID: 21092082    Free PMC article.
Analysing breast cancer microarrays from African Americans using shrinkage-based discriminant analysis.
Herbert Pang, Keita Ebisu, +2 authors, Tiejun Tong.
Hum Genomics, 2010 Nov 26; 5(1). PMID: 21106486    Free PMC article.
Regulation patterns in signaling networks of cancer.
Gunnar Schramm, Nandakumar Kannabiran, Rainer König.
BMC Syst Biol, 2010 Nov 30; 4. PMID: 21110851    Free PMC article.
The molecular pathology of breast cancer progression.
Alessandro Bombonati, Dennis C Sgroi.
J Pathol, 2010 Dec 03; 223(2). PMID: 21125683    Free PMC article.
Review.
Biomarkers in Barrett's esophagus and esophageal adenocarcinoma: predictors of progression and prognosis.
Chin-Ann J Ong, Pierre Lao-Sirieix, Rebecca C Fitzgerald.
World J Gastroenterol, 2010 Dec 04; 16(45). PMID: 21128316    Free PMC article.
Review.
Deconstructing the molecular portraits of breast cancer.
Aleix Prat, Charles M Perou.
Mol Oncol, 2010 Dec 15; 5(1). PMID: 21147047    Free PMC article.
Highly Cited. Review.
TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
Mirjam T Epping, Lars A T Meijer, +3 authors, René Bernards.
Nat Cell Biol, 2010 Dec 21; 13(1). PMID: 21170034
Molecular profiling currently offers no more than tumour morphology and basic immunohistochemistry.
Britta Weigelt, Jorge S Reis-Filho.
Breast Cancer Res, 2011 Jan 05; 12 Suppl 4. PMID: 21172089    Free PMC article.
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Maria Soledad Sosa, Cynthia Lopez-Haber, +10 authors, Marcelo G Kazanietz.
Mol Cell, 2010 Dec 22; 40(6). PMID: 21172654    Free PMC article.
Highly Cited.
Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features.
François Bertucci, Bruno Chetaille, Luc Xerri.
Adv Hematol, 2011 Jan 05; 2011. PMID: 21197104    Free PMC article.
Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures.
Cheng Fan, Aleix Prat, +4 authors, Charles M Perou.
BMC Med Genomics, 2011 Jan 11; 4. PMID: 21214954    Free PMC article.
Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.
Jack Cuzick, Gregory P Swanson, +18 authors, Transatlantic Prostate Group.
Lancet Oncol, 2011 Feb 12; 12(3). PMID: 21310658    Free PMC article.
Highly Cited.
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma.
Augusto Villanueva, Yujin Hoshida, +16 authors, Josep M Llovet.
Gastroenterology, 2011 Feb 16; 140(5). PMID: 21320499    Free PMC article.
Highly Cited.
Challenges to developing proteomic-based breast cancer diagnostics.
Richard R Drake, Lisa H Cazares, +3 authors, Christine Laronga.
OMICS, 2011 Feb 22; 15(5). PMID: 21332380    Free PMC article.
Review.
Can some patients avoid adjuvant chemotherapy for early-stage breast cancer?
Philippe L Bedard, Fatima Cardoso.
Nat Rev Clin Oncol, 2011 Mar 03; 8(5). PMID: 21364525
Review.
Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes?
Yotam Drier, Eytan Domany.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423753    Free PMC article.
Combining gene signatures improves prediction of breast cancer survival.
Xi Zhao, Einar Andreas Rødland, +6 authors, Ole Christian Lingjærde.
PLoS One, 2011 Mar 23; 6(3). PMID: 21423775    Free PMC article.
Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer.
Monique Chambon, Béatrice Orsetti, +8 authors, Vincent Cavaillès.
Am J Pathol, 2011 Mar 26; 178(4). PMID: 21435435    Free PMC article.
Exploring genomic profiles of hepatocellular carcinoma.
Hyun Goo Woo, Eun Sung Park, Snorri S Thorgeirsson, Yoon Jun Kim.
Mol Carcinog, 2011 Apr 06; 50(4). PMID: 21465573    Free PMC article.
Review.
Context-specific gene regulatory networks subdivide intrinsic subtypes of breast cancer.
Sara Nasser, Heather E Cunliffe, Michael A Black, Seungchan Kim.
BMC Bioinformatics, 2011 Apr 22; 12 Suppl 2. PMID: 21489222    Free PMC article.
Epigenetic Reactivation of Estrogen Receptor: Promising Tools for Restoring Response to Endocrine Therapy.
Neeraj K Saxena, Dipali Sharma.
Mol Cell Pharmacol, 2010 Jan 01; 2(5). PMID: 21499573    Free PMC article.
Breast cancer adjuvant therapy: time to consider its time-dependent effects.
Ismail Jatoi, William F Anderson, Jong-Hyeon Jeong, Carol K Redmond.
J Clin Oncol, 2011 May 11; 29(17). PMID: 21555693    Free PMC article.
The significance of HER-2/neu receptor positivity and immunophenotype in ductal carcinoma in situ with early invasive disease.
Shuko Harada, Rosemarie Mick, +7 authors, Paul J Zhang.
J Surg Oncol, 2011 May 11; 104(5). PMID: 21557226    Free PMC article.
Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial.
P-L Jerevall, X-J Ma, +9 authors, O Stål.
Br J Cancer, 2011 May 12; 104(11). PMID: 21559019    Free PMC article.
18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.
Nicolaos Palaskas, Steven M Larson, +20 authors, Ingo K Mellinghoff.
Cancer Res, 2011 Jun 08; 71(15). PMID: 21646475    Free PMC article.
Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
Yuh-Charn Lin, Chun-Chuan Chen, Chien-Jui Cheng, Ruey-Bing Yang.
J Biol Chem, 2011 Jun 10; 286(30). PMID: 21652720    Free PMC article.
Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer.
Wendy Weijia Soon, Lance David Miller, +7 authors, Edison T Liu.
EMBO Mol Med, 2011 Jun 10; 3(8). PMID: 21656687    Free PMC article.
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence.
James L Chen, Jianrong Li, Walter M Stadler, Yves A Lussier.
J Am Med Inform Assoc, 2011 Jun 16; 18(4). PMID: 21672909    Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction.
Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho.
Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441    Free PMC article.
Review.
Predictive and prognostic molecular markers for cancer medicine.
Sunali Mehta, Andrew Shelling, +4 authors, Cristin Print.
Ther Adv Med Oncol, 2010 Mar 01; 2(2). PMID: 21789130    Free PMC article.
Statistical association of basal cell keratins with metastasis-inducing proteins in a prognostically unfavorable group of sporadic breast cancers.
Suzete de Silva Rudland, Angela Platt-Higgins, +5 authors, Philip S Rudland.
Am J Pathol, 2011 Aug 02; 179(2). PMID: 21801876    Free PMC article.
Inferring causal genomic alterations in breast cancer using gene expression data.
Linh M Tran, Bin Zhang, +6 authors, Jun Zhu.
BMC Syst Biol, 2011 Aug 03; 5. PMID: 21806811    Free PMC article.
Histopathological and genomic grading provide complementary prognostic information in breast cancer: a study on publicly available datasets.
Nilotpal Chowdhury.
Patholog Res Int, 2011 Aug 17; 2011. PMID: 21845210    Free PMC article.
Murine mammary tumor cells with a claudin-low genotype.
Craig I Campbell, Devan E Thompson, Megan D Siwicky, Roger A Moorehead.
Cancer Cell Int, 2011 Aug 19; 11. PMID: 21846397    Free PMC article.
Triple-negative breast cancers: an updated review on treatment options.
K B Reddy.
Curr Oncol, 2011 Aug 30; 18(4). PMID: 21874107    Free PMC article.
An iron regulatory gene signature predicts outcome in breast cancer.
Lance D Miller, Lan G Coffman, +5 authors, Frank M Torti.
Cancer Res, 2011 Aug 31; 71(21). PMID: 21875943    Free PMC article.
Prognostic significance of breast cancer subtype and p53 overexpression in patients with locally advanced or high-risk breast cancer treated using upfront modified radical mastectomy with or without post-mastectomy radiation therapy.
Dong Soo Lee, Sung Hwan Kim, +3 authors, Byoung Yong Shim.
Int J Clin Oncol, 2011 Sep 08; 17(5). PMID: 21898181
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer.
Ana M Gonzalez-Angulo, Bryan T Hennessy, +19 authors, Gordon B Mills.
Clin Proteomics, 2011 Sep 13; 8(1). PMID: 21906370    Free PMC article.
Breast cancer subtype-specific interactions with the microenvironment dictate mechanisms of invasion.
Tuyen T Dang, Amanda M Prechtl, Gray W Pearson.
Cancer Res, 2011 Sep 13; 71(21). PMID: 21908556    Free PMC article.
Predictive Power Estimation Algorithm (PPEA)--a new algorithm to reduce overfitting for genomic biomarker discovery.
Jiangang Liu, Robert A Jolly, +7 authors, Tao Wei.
PLoS One, 2011 Sep 22; 6(9). PMID: 21935387    Free PMC article.
Epidemiology of triple negative breast cancers.
Gretchen L Gierach, Aileen Burke, William F Anderson.
Breast Dis, 2011 Oct 04; 32(1-2). PMID: 21965309    Free PMC article.
A clinically relevant gene signature in triple negative and basal-like breast cancer.
Achim Rody, Thomas Karn, +11 authors, Manfred Kaufmann.
Breast Cancer Res, 2011 Oct 08; 13(5). PMID: 21978456    Free PMC article.
Highly Cited.
Tumor metastasis: molecular insights and evolving paradigms.
Scott Valastyan, Robert A Weinberg.
Cell, 2011 Oct 18; 147(2). PMID: 22000009    Free PMC article.
Highly Cited. Review.
Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature.
S E Franks, C I Campbell, +4 authors, R A Moorehead.
Oncogene, 2011 Oct 25; 31(27). PMID: 22020329    Free PMC article.
A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.
Wendy L Allen, Leanne Stevenson, +8 authors, Patrick G Johnston.
Mol Cancer Ther, 2011 Oct 27; 11(1). PMID: 22027693    Free PMC article.
Most random gene expression signatures are significantly associated with breast cancer outcome.
David Venet, Jacques E Dumont, Vincent Detours.
PLoS Comput Biol, 2011 Oct 27; 7(10). PMID: 22028643    Free PMC article.
Highly Cited.
Effects of tissue handling on RNA integrity and microarray measurements from resected breast cancers.
Christos Hatzis, Hongxia Sun, +6 authors, W Fraser Symmans.
J Natl Cancer Inst, 2011 Oct 29; 103(24). PMID: 22034635    Free PMC article.
Altered expression of insulin receptor isoforms in breast cancer.
Jiaqi Huang, Chris Morehouse, +12 authors, Yihong Yao.
PLoS One, 2011 Nov 03; 6(10). PMID: 22046260    Free PMC article.
Basal breast cancer: a complex and deadly molecular subtype.
F Bertucci, P Finetti, D Birnbaum.
Curr Mol Med, 2011 Nov 16; 12(1). PMID: 22082486    Free PMC article.
Review.
Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies.
Angela Hui, Christine How, Emma Ito, Fei-Fei Liu.
BMC Cancer, 2011 Dec 02; 11. PMID: 22128797    Free PMC article.
Review.
Invasive Breast Cancer: Recognition of Molecular Subtypes.
Johanna D Strehl, David L Wachter, +2 authors, Arndt Hartmann.
Breast Care (Basel), 2011 Dec 03; 6(4). PMID: 22135623    Free PMC article.
Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.
Lee H Chen, Wen-Hung Kuo, +7 authors, King-Jen Chang.
PLoS One, 2011 Dec 06; 6(11). PMID: 22140552    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
A simple but highly effective approach to evaluate the prognostic performance of gene expression signatures.
Maud H W Starmans, Glenn Fung, +2 authors, Philippe Lambin.
PLoS One, 2011 Dec 14; 6(12). PMID: 22163293    Free PMC article.
Early developments in gene-expression profiling of breast tumors: potential for increasing black-white patient disparities in breast cancer outcomes?
Donna H Odierna, Aimee Afable-Munsuz, +5 authors, Ninez A Ponce.
Per Med, 2011 Dec 23; 8(6). PMID: 22190978    Free PMC article.
The influence of feature selection methods on accuracy, stability and interpretability of molecular signatures.
Anne-Claire Haury, Pierre Gestraud, Jean-Philippe Vert.
PLoS One, 2011 Dec 30; 6(12). PMID: 22205940    Free PMC article.
A three-gene model to robustly identify breast cancer molecular subtypes.
Benjamin Haibe-Kains, Christine Desmedt, +4 authors, Christos Sotiriou.
J Natl Cancer Inst, 2012 Jan 21; 104(4). PMID: 22262870    Free PMC article.
Highly Cited.
Gene expression profiling: changing face of breast cancer classification and management.
Robert Wesolowski, Bhuvaneswari Ramaswamy.
Gene Expr, 2012 Jan 25; 15(3). PMID: 22268293    Free PMC article.
Review.
Single sample expression-anchored mechanisms predict survival in head and neck cancer.
Xinan Yang, Kelly Regan, +6 authors, Yves A Lussier.
PLoS Comput Biol, 2012 Feb 01; 8(1). PMID: 22291585    Free PMC article.
Molecular basis of triple negative breast cancer and implications for therapy.
Parvin F Peddi, Matthew J Ellis, Cynthia Ma.
Int J Breast Cancer, 2012 Feb 02; 2012. PMID: 22295242    Free PMC article.
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Benjamin T Spike, Dannielle D Engle, +3 authors, Geoffrey M Wahl.
Cell Stem Cell, 2012 Feb 07; 10(2). PMID: 22305568    Free PMC article.
Highly Cited.
Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing.
Maram Al-Otaiby, Elena Tassi, +8 authors, Anton Wellstein.
Am J Pathol, 2012 Feb 22; 180(4). PMID: 22342158    Free PMC article.
Emerging therapeutic strategies for Epstein-Barr virus+ post-transplant lymphoproliferative disorder.
Olivia Hatton, Olivia M Martinez, Carlos O Esquivel.
Pediatr Transplant, 2012 Feb 23; 16(3). PMID: 22353174    Free PMC article.
Review.
A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.
Timothy J Molloy, Paul Roepman, Bjørn Naume, Laura J van't Veer.
PLoS One, 2012 Mar 03; 7(2). PMID: 22384245    Free PMC article.
Agreement in risk prediction between the 21-gene recurrence score assay (Oncotype DX®) and the PAM50 breast cancer intrinsic Classifier™ in early-stage estrogen receptor-positive breast cancer.
Catherine M Kelly, Philip S Bernard, +7 authors, Lajos Pusztai.
Oncologist, 2012 Mar 16; 17(4). PMID: 22418568    Free PMC article.
Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen.
A Prat, J S Parker, +9 authors, C M Perou.
Ann Oncol, 2012 Apr 26; 23(11). PMID: 22532584    Free PMC article.
FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.
Yun-Yong Park, Sung Yun Jung, +10 authors, Ju-Seog Lee.
Carcinogenesis, 2012 May 15; 33(10). PMID: 22581827    Free PMC article.
The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells.
Xiufen Li, Jinqiu Kuang, +5 authors, Scott K Kuwada.
J Biol Chem, 2012 May 17; 287(27). PMID: 22589551    Free PMC article.
The implications of breast cancer molecular phenotype for radiation oncology.
Shirin Sioshansi, Kathryn E Huber, David E Wazer.
Front Oncol, 2011 Jan 01; 1. PMID: 22649753    Free PMC article.
Dynamic modeling of genes controlling cancer stem cell proliferation.
Zhong Wang, Jingyuan Liu, +5 authors, Rongling Wu.
Front Genet, 2012 Jun 05; 3. PMID: 22661984    Free PMC article.
A 50-gene intrinsic subtype classifier for prognosis and prediction of benefit from adjuvant tamoxifen.
Stephen K Chia, Vivien H Bramwell, +12 authors, Torsten O Nielsen.
Clin Cancer Res, 2012 Jun 20; 18(16). PMID: 22711706    Free PMC article.
Highly Cited.
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers.
Erhan Bilal, Kristen Vassallo, +8 authors, Shridar Ganesan.
PLoS One, 2012 Jun 22; 7(6). PMID: 22719901    Free PMC article.
Independent and functional validation of a multi-tumour-type proliferation signature.
M H W Starmans, N G Lieuwes, +8 authors, P Lambin.
Br J Cancer, 2012 Jun 23; 107(3). PMID: 22722312    Free PMC article.
Signatures of tumor-immune interactions as biomarkers for breast cancer prognosis.
Masoud H Manjili, Kayvan Najarian, Xiang-Yang Wang.
Future Oncol, 2012 Jul 07; 8(6). PMID: 22764768    Free PMC article.
Review.
Cancer develops, progresses and responds to therapies through restricted perturbation of the protein-protein interaction network.
Jordi Serra-Musach, Helena Aguilar, +5 authors, Miguel Angel Pujana.
Integr Biol (Camb), 2012 Jul 19; 4(9). PMID: 22806580    Free PMC article.
A network-based gene expression signature informs prognosis and treatment for colorectal cancer patients.
Mingguang Shi, R Daniel Beauchamp, Bing Zhang.
PLoS One, 2012 Jul 31; 7(7). PMID: 22844451    Free PMC article.
Clinical importance of phosphatase of regenerating liver-3 expression in breast cancer.
Bala Basak Oven Ustaalioglu, Ahmet Bilici, +5 authors, Mahmut Gumus.
Clin Transl Oncol, 2012 Aug 03; 14(12). PMID: 22855168
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity.
Aaron Boudreau, Laura J van't Veer, Mina J Bissell.
Cell Adh Migr, 2012 Aug 07; 6(3). PMID: 22863741    Free PMC article.
Review.
Challenges of incorporating gene expression data to predict HCC prognosis in the age of systems biology.
Yan Du, Guang-Wen Cao.
World J Gastroenterol, 2012 Aug 23; 18(30). PMID: 22912544    Free PMC article.
Developing and validating continuous genomic signatures in randomized clinical trials for predictive medicine.
Shigeyuki Matsui, Richard Simon, +3 authors, John Crowley.
Clin Cancer Res, 2012 Aug 29; 18(21). PMID: 22927484    Free PMC article.
A sample selection strategy to boost the statistical power of signature detection in cancer expression profile studies.
Zhenyu Jia, Yipeng Wang, +8 authors, Dan Mercola.
Anticancer Agents Med Chem, 2012 Sep 01; 13(2). PMID: 22934703    Free PMC article.
The molecular profile of luminal B breast cancer.
Chad J Creighton.
Biologics, 2012 Sep 08; 6. PMID: 22956860    Free PMC article.
The interaction between ER and NFκB in resistance to endocrine therapy.
Leen Sas, Filip Lardon, +5 authors, Steven J Van Laere.
Breast Cancer Res, 2012 Sep 12; 14(4). PMID: 22963717    Free PMC article.
Review.
Development and validation of a prognostic gene-expression signature for lung adenocarcinoma.
Yun-Yong Park, Eun Sung Park, +7 authors, Ju-Seog Lee.
PLoS One, 2012 Sep 13; 7(9). PMID: 22970185    Free PMC article.
Identification of common prognostic gene expression signatures with biological meanings from microarray gene expression datasets.
Jun Yao, Qi Zhao, +4 authors, John N Weinstein.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029298    Free PMC article.
Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population.
Chi-Cheng Huang, Shih-Hsin Tu, +7 authors, Eric Y Chuang.
J Transl Med, 2012 Oct 25; 10 Suppl 1. PMID: 23046482    Free PMC article.
Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis.
Medical Advisory Secretariat.
Ont Health Technol Assess Ser, 2010 Jan 01; 10(23). PMID: 23074401    Free PMC article.
Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers.
Kristin Jonsdottir, Susanne R Janssen, +4 authors, Emiel A M Janssen.
PLoS One, 2012 Nov 13; 7(11). PMID: 23144930    Free PMC article.
Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors.
Marcus Schmidt, Patrick Micke, Mathias Gehrmann, Jan G Hengstler.
Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170262    Free PMC article.
An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis.
Françoise Bonnet, Mickael Guedj, +14 authors, Michel Longy.
BMC Med Genomics, 2012 Nov 29; 5. PMID: 23186559    Free PMC article.
A DNA repair BRCA1 estrogen receptor and targeted therapy in breast cancer.
Adisorn Ratanaphan.
Int J Mol Sci, 2012 Dec 04; 13(11). PMID: 23203101    Free PMC article.
Review.
Clinical and multiple gene expression variables in survival analysis of breast cancer: analysis with the hypertabastic survival model.
Mohammad A Tabatabai, Wayne M Eby, +2 authors, Karan P Singh.
BMC Med Genomics, 2012 Dec 18; 5. PMID: 23241496    Free PMC article.
Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.
Yves A Lussier, Nikolai N Khodarev, +15 authors, Ralph R Weichselbaum.
PLoS One, 2012 Dec 20; 7(12). PMID: 23251360    Free PMC article.
Challenges in Biomarker Discovery: Combining Expert Insights with Statistical Analysis of Complex Omics Data.
Jason E McDermott, Jing Wang, +4 authors, Karin D Rodland.
Expert Opin Med Diagn, 2013 Jan 22; 7(1). PMID: 23335946    Free PMC article.
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.
David H Nguyen, Erik Fredlund, +4 authors, Mary Helen Barcellos-Hoff.
Clin Cancer Res, 2013 Jan 23; 19(6). PMID: 23339125    Free PMC article.
Translating metastasis-related biomarkers to the clinic--progress and pitfalls.
François-Clément Bidard, Jean-Yves Pierga, Jean-Charles Soria, Jean Paul Thiery.
Nat Rev Clin Oncol, 2013 Feb 06; 10(3). PMID: 23381003
Review.
A data similarity-based strategy for meta-analysis of transcriptional profiles in cancer.
Qingchao Qiu, Pengcheng Lu, +6 authors, Yajun Yi.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383020    Free PMC article.
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways.
Margit L H Riis, Xi Zhao, +6 authors, Vessela N Kristensen.
ISRN Oncol, 2013 Mar 28; 2013. PMID: 23533813    Free PMC article.
Specific siRNA targeting receptor for advanced glycation end products (RAGE) decreases proliferation in human breast cancer cell lines.
Al-Madhagi Radia, Al-Madhagi Yaser, +7 authors, Wei Wang.
Int J Mol Sci, 2013 Apr 13; 14(4). PMID: 23579957    Free PMC article.
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer.
Stefano Volinia, Carlo M Croce.
Proc Natl Acad Sci U S A, 2013 Apr 17; 110(18). PMID: 23589849    Free PMC article.
Highly Cited.
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Il-Jin Kim, David Quigley, +9 authors, Allan Balmain.
Nat Commun, 2013 Apr 18; 4. PMID: 23591868    Free PMC article.
Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.
Srikanth Nagalla, Jeff W Chou, +9 authors, Lance D Miller.
Genome Biol, 2013 Apr 27; 14(4). PMID: 23618380    Free PMC article.
Highly Cited.
Identification and validation of a new set of five genes for prediction of risk in early breast cancer.
Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi.
Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477    Free PMC article.
Multiple suboptimal solutions for prediction rules in gene expression data.
Osamu Komori, Mari Pritchard, Shinto Eguchi.
Comput Math Methods Med, 2013 May 11; 2013. PMID: 23662163    Free PMC article.
Efficacy, safety, pharmacokinetics and biomarker findings in patients with HER2-positive advanced or metastatic breast cancer treated with lapatinib in combination with capecitabine: results from 51 Japanese patients treated in a clinical study.
Hiroji Iwata, Hirofumi Fujii, +6 authors, Seigo Nakamura.
Breast Cancer, 2013 May 22; 22(2). PMID: 23689990    Free PMC article.
Genomic biomarkers for personalized medicine: development and validation in clinical studies.
Shigeyuki Matsui.
Comput Math Methods Med, 2013 May 22; 2013. PMID: 23690882    Free PMC article.
Review.
TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.
Virginie Maire, Céline Baldeyron, +15 authors, Thierry Dubois.
PLoS One, 2013 May 24; 8(5). PMID: 23700430    Free PMC article.
p16 expression correlates with basal-like triple-negative breast carcinoma.
Amany A Abou-Bakr, Hany I Eldweny.
Ecancermedicalscience, 2013 May 30; 7. PMID: 23717338    Free PMC article.
Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses.
Roman Rouzier, Paolo Pronzato, +3 authors, William J Valentine.
Breast Cancer Res Treat, 2013 Jun 01; 139(3). PMID: 23722312    Free PMC article.
Systematic Review.
Integrative analysis of cancer-related signaling pathways.
Thomas Kessler, Hendrik Hache, Christoph Wierling.
Front Physiol, 2013 Jun 14; 4. PMID: 23760067    Free PMC article.
Predictive accuracy of covariates for event times.
Li Chen, D Y Lin, Donglin Zeng.
Biometrika, 2013 Jul 12; 99(3). PMID: 23843671    Free PMC article.
Using large-scale molecular data sets to improve breast cancer treatment.
Chad J Creighton.
Breast Cancer Manag, 2012 May 01; 1(1). PMID: 23869198    Free PMC article.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Review.
The molecular diversity of Luminal A breast tumors.
Giovanni Ciriello, Rileen Sinha, +5 authors, Nikolaus Schultz.
Breast Cancer Res Treat, 2013 Oct 08; 141(3). PMID: 24096568    Free PMC article.
Concurrent gene signatures for han chinese breast cancers.
Chi-Cheng Huang, Shih-Hsin Tu, +5 authors, Eric Y Chuang.
PLoS One, 2013 Oct 08; 8(10). PMID: 24098497    Free PMC article.
Hybrid method for prediction of metastasis in breast cancer patients using gene expression signals.
Alireza Mehri Dehnavi, Mohammad Reza Sehhati, Hossein Rabbani.
J Med Signals Sens, 2013 Oct 08; 3(2). PMID: 24098861    Free PMC article.
A robust prognostic signature for hormone-positive node-negative breast cancer.
Obi L Griffith, François Pepin, +4 authors, Joe W Gray.
Genome Med, 2013 Oct 12; 5(10). PMID: 24112773    Free PMC article.
Obesity, metabolism and the microenvironment: Links to cancer.
Sneha Sundaram, Amy R Johnson, Liza Makowski.
J Carcinog, 2013 Nov 15; 12. PMID: 24227994    Free PMC article.
Review.
Two-gene expression ratio as predictor for breast cancer treated with tamoxifen: evidence from meta-analysis.
Lin Zhao, Shimiao Zhu, Ying Gao, Yaogang Wang.
Tumour Biol, 2013 Nov 23; 35(4). PMID: 24264313
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling.
Y Yu, C-H Xiao, +3 authors, Y-M Feng.
Br J Cancer, 2013 Dec 18; 110(3). PMID: 24335925    Free PMC article.
Highly Cited.
Pituitary tumor-transforming gene 1 is expressed in primary ductal breast carcinoma, lymph node infiltration, and distant metastases.
Fabio Grizzi, Sonia Di Biccari, +2 authors, Piergiuseppe Colombo.
Dis Markers, 2013 Dec 18; 35(4). PMID: 24344401    Free PMC article.
Identifying breast cancer subtype related miRNAs from two constructed miRNAs interaction networks in silico method.
Lin Hua, Lin Li, Ping Zhou.
Biomed Res Int, 2013 Dec 19; 2013. PMID: 24350289    Free PMC article.
Micro-RNAs as potential new molecular biomarkers in oncology: have they reached relevance for the clinical imaging sciences?
Frank Berger, Maximilian F Reiser.
Theranostics, 2014 Jan 08; 3(12). PMID: 24396505    Free PMC article.
Review.
Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity.
Denise M Wolf, Marc E Lenburg, +2 authors, Laura J van 't Veer.
PLoS One, 2014 Feb 12; 9(2). PMID: 24516633    Free PMC article.
Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.
Erica B Schleifman, Rupal Desai, +13 authors, Mark R Lackner.
PLoS One, 2014 Feb 13; 9(2). PMID: 24520381    Free PMC article.
Which threshold for ER positivity? a retrospective study based on 9639 patients.
M Yi, L Huo, +11 authors, K K Hunt.
Ann Oncol, 2014 Feb 25; 25(5). PMID: 24562447    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Invasive breast cancer: stratification of histological grade by gene-based assays: a still relevant example from an older data set.
Leslie Dalton.
Histopathology, 2014 Mar 29; 65(3). PMID: 24673556    Free PMC article.
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility.
P Sinn, S Aulmann, +6 authors, A Schneeweiss.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(9). PMID: 24771945    Free PMC article.
US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status.
Nadia Howlader, Sean F Altekruse, +4 authors, Kathleen A Cronin.
J Natl Cancer Inst, 2014 Apr 30; 106(5). PMID: 24777111    Free PMC article.
Highly Cited.
Circulating tumor cells predict survival in early average-to-high risk breast cancer patients.
Brigitte Rack, Christian Schindlbeck, +15 authors, SUCCESS Study Group.
J Natl Cancer Inst, 2014 May 17; 106(5). PMID: 24832787    Free PMC article.
Highly Cited.
The use of Bayesian hierarchical models for adaptive randomization in biomarker-driven phase II studies.
William T Barry, Charles M Perou, +2 authors, Joseph G Ibrahim.
J Biopharm Stat, 2014 May 20; 25(1). PMID: 24836519    Free PMC article.
Extracts from Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro.
Xiu-Fei Gao, Qing-Lin Li, +5 authors, Ai-Qin Zhang.
Evid Based Complement Alternat Med, 2014 Jun 03; 2014. PMID: 24883070    Free PMC article.
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.
Thomas E Rohan, Xiaonan Xue, +10 authors, Joan G Jones.
J Natl Cancer Inst, 2014 Jun 05; 106(8). PMID: 24895374    Free PMC article.
Highly Cited.
Late recurrences in early breast cancer: for whom and how long is endocrine therapy beneficial?
Michael Knauer, Martin Filipits, Peter Dubsky.
Breast Care (Basel), 2014 Jun 20; 9(2). PMID: 24944551    Free PMC article.
Review.
Functional characterization of breast cancer using pathway profiles.
Feng Tian, Yajie Wang, Michael Seiler, Zhenjun Hu.
BMC Med Genomics, 2014 Jul 22; 7. PMID: 25041817    Free PMC article.
Biological subtypes of breast cancer: Prognostic and therapeutic implications.
Ozlem Yersal, Sabri Barutca.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114856    Free PMC article.
Highly Cited. Review.
How many etiological subtypes of breast cancer: two, three, four, or more?
William F Anderson, Philip S Rosenberg, +2 authors, Mark E Sherman.
J Natl Cancer Inst, 2014 Aug 15; 106(8). PMID: 25118203    Free PMC article.
Highly Cited. Review.
Moving towards personalized medicine in rheumatoid arthritis.
Tamarah D de Jong, Saskia Vosslamber, Cornelis L Verweij.
Arthritis Res Ther, 2014 Aug 29; 16(3). PMID: 25166016    Free PMC article.
Genome-based risk prediction for early stage breast cancer.
Christina Adaniel, Komal Jhaveri, Adriana Heguy, Francisco J Esteva.
Oncologist, 2014 Sep 05; 19(10). PMID: 25187476    Free PMC article.
Review.
A novel model to combine clinical and pathway-based transcriptomic information for the prognosis prediction of breast cancer.
Sijia Huang, Cameron Yee, +2 authors, Lana X Garmire.
PLoS Comput Biol, 2014 Sep 19; 10(9). PMID: 25233347    Free PMC article.
Immunohistochemical detection improves the prognostic value of lymphatic and blood vessel invasion in primary ductal breast cancer.
Fadia J A Gujam, James J Going, +3 authors, Donald C McMillan.
BMC Cancer, 2014 Sep 23; 14. PMID: 25234410    Free PMC article.
TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients.
Sandra V Fernandez, Catherine Bingham, +5 authors, Massimo Cristofanilli.
Breast Cancer Res, 2014 Oct 14; 16(5). PMID: 25307991    Free PMC article.
Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice.
Sneha Sundaram, Alex J Freemerman, +5 authors, Liza Makowski.
PLoS One, 2014 Oct 30; 9(10). PMID: 25354395    Free PMC article.
Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases.
L Bollen, C Wibmer, +9 authors, P D S Dijkstra.
Clin Exp Metastasis, 2014 Nov 02; 32(1). PMID: 25359620
A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft.
Daniel Baron, Gérard Ramstein, +11 authors, Sophie Brouard.
Kidney Int, 2015 Jan 30; 87(5). PMID: 25629549    Free PMC article.
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival.
Ivan O Potapenko, Torben Lüders, +7 authors, Vilde D Haakensen.
Mol Oncol, 2015 Feb 07; 9(4). PMID: 25655580    Free PMC article.
Study of integrated heterogeneous data reveals prognostic power of gene expression for breast cancer survival.
Richard E Neapolitan, Xia Jiang.
PLoS One, 2015 Feb 28; 10(2). PMID: 25723490    Free PMC article.
Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.
Maurice P H M Jansen, Leen Sas, +20 authors, Steven Van Laere.
Mol Oncol, 2015 Mar 17; 9(6). PMID: 25771305    Free PMC article.
Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis.
Ping Wu, Xizhou Li, +5 authors, Weiqiang Zheng.
Contemp Oncol (Pozn), 2014 Jan 01; 18(6). PMID: 25784836    Free PMC article.
Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State.
Betsy A Kohler, Recinda L Sherman, +11 authors, Lynne Penberthy.
J Natl Cancer Inst, 2015 Apr 01; 107(6). PMID: 25825511    Free PMC article.
Highly Cited.
Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.
Angelika Modelska, Alessandro Quattrone, Angela Re.
Brief Bioinform, 2015 Apr 03; 16(6). PMID: 25832647    Free PMC article.
Review.
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value.
Brian David Lehmann, Yan Ding, +6 authors, Yajun Yi.
BMC Cancer, 2015 Apr 18; 15. PMID: 25886164    Free PMC article.
Expression of cell cycle-regulated genes and prostate cancer prognosis in a population-based cohort.
Rohina Rubicz, Shanshan Zhao, +9 authors, Janet L Stanford.
Prostate, 2015 May 21; 75(13). PMID: 25990700    Free PMC article.
Application of quantitative proteomics to the integrated analysis of the ubiquitylated and global proteomes of xenograft tumor tissues.
Stefani N Thomas, Hui Zhang, Robert J Cotter.
Clin Proteomics, 2015 May 29; 12(1). PMID: 26019700    Free PMC article.
Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics.
Justin Stebbing, Hua Zhang, +4 authors, Georgios Giamas.
Mol Cell Proteomics, 2015 Jun 20; 14(9). PMID: 26089344    Free PMC article.
Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study.
Noran Aboalela, Debra Lyon, +4 authors, Colleen Jackson-Cook.
PLoS One, 2015 Jul 16; 10(7). PMID: 26177092    Free PMC article.
Knowledge transfer via classification rules using functional mapping for integrative modeling of gene expression data.
Henry A Ogoe, Shyam Visweswaran, Xinghua Lu, Vanathi Gopalakrishnan.
BMC Bioinformatics, 2015 Jul 24; 16. PMID: 26202217    Free PMC article.
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.
Zhanwei Wang, Dionyssios Katsaros, +7 authors, Herbert Yu.
PLoS One, 2015 Aug 20; 10(8). PMID: 26287798    Free PMC article.
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Xiaoping Zhu, Jing Zhong, +7 authors, Stephen Wong.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26318291    Free PMC article.
ERRα Is a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer.
Subrata Manna, Josefine Bostner, +9 authors, Marina K Holz.
Clin Cancer Res, 2015 Nov 07; 22(6). PMID: 26542058    Free PMC article.
Bayesian predictive modeling for genomic based personalized treatment selection.
Junsheng Ma, Francesco C Stingo, Brian P Hobbs.
Biometrics, 2015 Nov 18; 72(2). PMID: 26575856    Free PMC article.
Biomarkers in Breast Cancer - An Update.
M Schmidt, P A Fasching, M W Beckmann, H Kölbl.
Geburtshilfe Frauenheilkd, 2012 Sep 01; 72(9). PMID: 26640290    Free PMC article.
Breast cancer intrinsic subtype classification, clinical use and future trends.
Xiaofeng Dai, Ting Li, +4 authors, Bozhi Shi.
Am J Cancer Res, 2015 Dec 23; 5(10). PMID: 26693050    Free PMC article.
Highly Cited. Review.
Statistical Significance of Clustering using Soft Thresholding.
Hanwen Huang, Yufeng Liu, Ming Yuan, J S Marron.
J Comput Graph Stat, 2016 Jan 13; 24(4). PMID: 26755893    Free PMC article.
High Proliferation Predicts Pathological Complete Response to Neoadjuvant Chemotherapy in Early Breast Cancer.
Emilio Alba, Ana Lluch, +18 authors, Federico Rojo.
Oncologist, 2016 Jan 21; 21(2). PMID: 26786263    Free PMC article.
Low Concordance between Gene Expression Signatures in ER Positive HER2 Negative Breast Carcinoma Could Impair Their Clinical Application.
Enora Laas, Peter Mallon, +3 authors, Fabien Reyal.
PLoS One, 2016 Feb 20; 11(2). PMID: 26895349    Free PMC article.
Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study.
Miguel Martin, Jan C Brase, +15 authors, Alvaro Rodriguez-Lescure.
Breast Cancer Res Treat, 2016 Feb 26; 156(1). PMID: 26909792    Free PMC article.
Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis.
Subapriya Rajamanickam, Subbarayalu Panneerdoss, +10 authors, Manjeet K Rao.
Clin Cancer Res, 2016 Mar 02; 22(14). PMID: 26927663    Free PMC article.
Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors.
Marion Lapierre, Aurélien Linares, +13 authors, Vincent Cavaillès.
Oncotarget, 2016 Mar 02; 7(15). PMID: 26930713    Free PMC article.
S100A8/A9 is associated with estrogen receptor loss in breast cancer.
Y I Bao, Antao Wang, Juanfen Mo.
Oncol Lett, 2016 Mar 22; 11(3). PMID: 26998104    Free PMC article.
An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.
Skye H Cheng, Chen-Fang Horng, +6 authors, Andrew T Huang.
EBioMedicine, 2016 Apr 15; 5. PMID: 27077114    Free PMC article.
Antibody Therapeutics in Oncology.
Erik D Wold, Vaughn V Smider, Brunhilde H Felding.
Immunotherapy (Los Angel), 2016 Apr 16; 2(1). PMID: 27081677    Free PMC article.
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others.
John M S Bartlett, Jane Bayani, +18 authors, OPTIMA TMG.
J Natl Cancer Inst, 2016 May 01; 108(9). PMID: 27130929    Free PMC article.
MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.
Hui Li, Yitan Zhu, +13 authors, Maryellen L Giger.
Radiology, 2016 Oct 19; 281(2). PMID: 27144536    Free PMC article.
Highly Cited.
A New Approach for Identification of Cancer-related Pathways using Protein Networks and Genomic Data.
André Fonseca, Marco D Gubitoso, +2 authors, Junior Barrera.
Cancer Inform, 2015 Jan 01; 14(Suppl 5). PMID: 27158220    Free PMC article.
TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer.
Rinath Jeselsohn, William T Barry, +10 authors, Luca Malorni.
Clin Cancer Res, 2016 Nov 01; 22(23). PMID: 27185372    Free PMC article.
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FREQUENT SUBGRAPH MINING OF PERSONALIZED SIGNALING PATHWAY NETWORKS GROUPS PATIENTS WITH FREQUENTLY DYSREGULATED DISEASE PATHWAYS AND PREDICTS PROGNOSIS.
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Polyphenols as Promising Drugs against Main Breast Cancer Signatures.
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The Era of Multigene Panels Comes? The Clinical Utility of Oncotype DX and MammaPrint.
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Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis.
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