Journal Article
. 2006 Sep; 74(11):6387-97.
doi: 10.1128/IAI.01088-06.

Cytosolic entry controls CD8+-T-cell potency during bacterial infection

Keith S Bahjat 1 Weiqun Liu  Edward E Lemmens  Stephen P Schoenberger  Daniel A Portnoy  Thomas W Dubensky  Dirk G Brockstedt  
Affiliations
  • PMID: 16954391
  •     56 References
  •     39 citations

Abstract

Interaction with host immunoreceptors during microbial infection directly impacts the magnitude of the ensuing innate immune response. How these signals affect the quality of the adaptive T-cell response remains poorly understood. Utilizing an engineered strain of the intracellular pathogen Listeria monocytogenes that infects cells but fails to escape from the phagosome, we demonstrate the induction of long-lived memory T cells that are capable of secondary expansion and effector function but are incapable of providing protective immunity. We demonstrate that microbial invasion of the cytosol is required for dendritic cell activation and integration of CD40 signaling, ultimately determining the ability of the elicited CD8+-T-cell pool to protect against lethal wild-type L. monocytogenes challenge. These results reveal a crucial role for phagosomal escape, not for delivery of antigen to the class I major histocompatibility complex pathway but for establishing the appropriate cellular context during CD8+-T-cell priming.

A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes.
G Geginat, S Schenk, +2 authors, H Hof.
J Immunol, 2001 Feb 13; 166(3). PMID: 11160235
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
F Hayashi, K D Smith, +7 authors, A Aderem.
Nature, 2001 Apr 27; 410(6832). PMID: 11323673
Highly Cited.
Natural adjuvants: endogenous activators of dendritic cells.
S Gallucci, M Lolkema, P Matzinger.
Nat Med, 1999 Nov 05; 5(11). PMID: 10545990
Highly Cited.
Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.
A Rodriguez, A Regnault, +2 authors, S Amigorena.
Nat Cell Biol, 1999 Nov 24; 1(6). PMID: 10559964
Highly Cited.
Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice.
S M Santini, C Lapenta, +4 authors, F Belardelli.
J Exp Med, 2000 May 17; 191(10). PMID: 10811870    Free PMC article.
Highly Cited.
CD8+ T cell effector mechanisms in resistance to infection.
J T Harty, A R Tvinnereim, D W White.
Annu Rev Immunol, 2000 Jun 03; 18. PMID: 10837060
Highly Cited. Review.
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal.
O Schulz, A D Edwards, +4 authors, C Reis e Sousa.
Immunity, 2000 Nov 09; 13(4). PMID: 11070164
Highly Cited.
Priming of memory but not effector CD8 T cells by a killed bacterial vaccine.
G Lauvau, S Vijh, +5 authors, E G Pamer.
Science, 2001 Nov 27; 294(5547). PMID: 11721060
Type I interferons produced by dendritic cells promote their phenotypic and functional activation.
Maria Montoya, Giovanna Schiavoni, +4 authors, David F Tough.
Blood, 2002 Apr 20; 99(9). PMID: 11964292
Highly Cited.
Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors.
Peter Lauer, Man Yin Nora Chow, +2 authors, Richard Calendar.
J Bacteriol, 2002 Jul 11; 184(15). PMID: 12107135    Free PMC article.
Highly Cited.
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Steffen Jung, Derya Unutmaz, +10 authors, Richard A Lang.
Immunity, 2002 Aug 28; 17(2). PMID: 12196292    Free PMC article.
Highly Cited.
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.
Mary O'Riordan, Caroline H Yi, +2 authors, Daniel A Portnoy.
Proc Natl Acad Sci U S A, 2002 Oct 03; 99(21). PMID: 12359878    Free PMC article.
Highly Cited.
T cell fitness determined by signal strength.
Amanda V Gett, Federica Sallusto, Antonio Lanzavecchia, Jens Geginat.
Nat Immunol, 2003 Mar 18; 4(4). PMID: 12640450
Highly Cited.
Requirement for CD4 T cell help in generating functional CD8 T cell memory.
Devon J Shedlock, Hao Shen.
Science, 2003 Apr 12; 300(5617). PMID: 12690201
Highly Cited.
Defective CD8 T cell memory following acute infection without CD4 T cell help.
Joseph C Sun, Michael J Bevan.
Science, 2003 Apr 12; 300(5617). PMID: 12690202    Free PMC article.
Highly Cited.
ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Pierre Guermonprez, Loredana Saveanu, +3 authors, Sebastian Amigorena.
Nature, 2003 Sep 26; 425(6956). PMID: 14508489
Highly Cited.
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon.
Agnes Le Bon, Nathalie Etchart, +5 authors, David F Tough.
Nat Immunol, 2003 Sep 23; 4(10). PMID: 14502286
Highly Cited.
Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses.
Gabrielle T Belz, Christopher M Smith, +4 authors, William R Heath.
J Immunol, 2004 Feb 07; 172(4). PMID: 14764661
Highly Cited.
Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
David Torres, Mathieu Barrier, +5 authors, François Erard.
Infect Immun, 2004 Mar 25; 72(4). PMID: 15039335    Free PMC article.
Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens.
Amy R Tvinnereim, Sara E Hamilton, John T Harty.
J Immunol, 2004 Jul 22; 173(3). PMID: 15265934
A specific gene expression program triggered by Gram-positive bacteria in the cytosol.
Ramona L McCaffrey, Paul Fawcett, +4 authors, Daniel A Portnoy.
Proc Natl Acad Sci U S A, 2004 Jul 23; 101(31). PMID: 15269347    Free PMC article.
Cytoplasmic entry of Listeria monocytogenes enhances dendritic cell maturation and T cell differentiation and function.
Kristina L Brzoza, Andrea B Rockel, Elizabeth M Hiltbold.
J Immunol, 2004 Aug 06; 173(4). PMID: 15294981
Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
Victoria Auerbuch, Dirk G Brockstedt, +2 authors, Daniel A Portnoy.
J Exp Med, 2004 Aug 11; 200(4). PMID: 15302899    Free PMC article.
Highly Cited.
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.
Joseph C Sun, Matthew A Williams, Michael J Bevan.
Nat Immunol, 2004 Aug 10; 5(9). PMID: 15300249    Free PMC article.
Highly Cited.
Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Dirk G Brockstedt, Martin A Giedlin, +7 authors, Thomas W Dubensky.
Proc Natl Acad Sci U S A, 2004 Sep 15; 101(38). PMID: 15365184    Free PMC article.
Highly Cited.
Immune responses to Listeria monocytogenes.
Eric G Pamer.
Nat Rev Immunol, 2004 Oct 02; 4(10). PMID: 15459672
Highly Cited. Review.
Minor H antigens introduced on H-2 different stimulating cells cross-react at the cytotoxic T cell level during in vivo priming.
M J Bevan.
J Immunol, 1976 Dec 01; 117(6). PMID: 825578
Highly Cited.
Failure of killed Listeria monocytogenes vaccine to produce protective immunity.
C H von Koenig, H Finger, H Hof.
Nature, 1982 May 20; 297(5863). PMID: 6176874
Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell-mediated immunity.
P Berche, J L Gaillard, P J Sansonetti.
J Immunol, 1987 Apr 01; 138(7). PMID: 3104455
Highly Cited.
T cell recognition of listeriolysin O is induced during infection with Listeria monocytogenes.
P Berche, J L Gaillard, C Geoffroy, J E Alouf.
J Immunol, 1987 Dec 01; 139(11). PMID: 3119720
Role of hemolysin for the intracellular growth of Listeria monocytogenes.
D A Portnoy, P S Jacks, D J Hinrichs.
J Exp Med, 1988 Apr 01; 167(4). PMID: 2833557    Free PMC article.
Highly Cited.
Detection of anti-listeriolysin O for serodiagnosis of human listeriosis.
P Berche, K A Reich, +7 authors, H Kreis.
Lancet, 1990 Mar 17; 335(8690). PMID: 1969016
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
L M Brunt, D A Portnoy, E R Unanue.
J Immunol, 1990 Dec 01; 145(11). PMID: 2147195
Highly Cited.
Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes.
E G Pamer, J T Harty, M J Bevan.
Nature, 1991 Oct 31; 353(6347). PMID: 1719425    Free PMC article.
Highly Cited.
Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread.
R A Barry, H G Bouwer, D A Portnoy, D J Hinrichs.
Infect Immun, 1992 Apr 01; 60(4). PMID: 1548084    Free PMC article.
Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection.
C H Ladel, I E Flesch, J Arnoldi, S H Kaufmann.
J Immunol, 1994 Oct 01; 153(7). PMID: 7726898
Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.
G Ikonomidis, Y Paterson, F J Kos, D A Portnoy.
J Exp Med, 1994 Dec 01; 180(6). PMID: 7964496    Free PMC article.
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
M Cella, D Scheidegger, +3 authors, G Alber.
J Exp Med, 1996 Aug 01; 184(2). PMID: 8760829    Free PMC article.
Highly Cited.
CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells.
P Björck, J Banchereau, L Flores-Romo.
Int Immunol, 1997 Mar 01; 9(3). PMID: 9088975
Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.
H Shen, J F Miller, +3 authors, J T Harty.
Cell, 1998 Mar 10; 92(4). PMID: 9491894
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs.
M L Albert, B Sauter, N Bhardwaj.
Nature, 1998 Mar 24; 392(6671). PMID: 9510252
Highly Cited.
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.
S P Schoenberger, R E Toes, +2 authors, C J Melief.
Nature, 1998 Jun 12; 393(6684). PMID: 9624005
Highly Cited.
Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.
M A Moors, B Levitt, P Youngman, D A Portnoy.
Infect Immun, 1998 Dec 24; 67(1). PMID: 9864207    Free PMC article.
Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection.
L P Cousens, R Peterson, +4 authors, C A Biron.
J Exp Med, 1999 Apr 20; 189(8). PMID: 10209048    Free PMC article.
Highly Cited.
Delivery of protein to the cytosol of macrophages using Escherichia coli K-12.
D E Higgins, N Shastri, D A Portnoy.
Mol Microbiol, 1999 Apr 21; 31(6). PMID: 10209738
Immunization of mice against Listeria monocytogenes.
H F HASENCLEVER, W W KARAKAWA.
J Bacteriol, 1957 Nov 01; 74(5). PMID: 13480995    Free PMC article.
Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes.
Eric Muraille, Rielle Giannino, +4 authors, Gregoire Lauvau.
Eur J Immunol, 2005 Apr 09; 35(5). PMID: 15816001
Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.
Reinhard Obst, Hisse-Martien van Santen, Diane Mathis, Christophe Benoist.
J Exp Med, 2005 May 18; 201(10). PMID: 15897273    Free PMC article.
Highly Cited.
CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo.
Gabrielle T Belz, Ken Shortman, Michael J Bevan, William R Heath.
J Immunol, 2005 Jun 24; 175(1). PMID: 15972648    Free PMC article.
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells.
Giorgio Napolitani, Andrea Rinaldi, +2 authors, Antonio Lanzavecchia.
Nat Immunol, 2005 Jul 05; 6(8). PMID: 15995707    Free PMC article.
Highly Cited.
Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity.
D G Brockstedt, K S Bahjat, +16 authors, T W Dubensky.
Nat Med, 2005 Jul 26; 11(8). PMID: 16041382
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
Daniel B Stetson, Ruslan Medzhitov.
Immunity, 2006 Jan 18; 24(1). PMID: 16413926
Highly Cited.
Vaccination with irradiated Listeria induces protective T cell immunity.
Sandip K Datta, Sharon Okamoto, +6 authors, Eyal Raz.
Immunity, 2006 Jul 25; 25(1). PMID: 16860763
Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens.
Lauren A Zenewicz, Kathryn E Foulds, +2 authors, Hao Shen.
J Immunol, 2002 Nov 08; 169(10). PMID: 12421961
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.
Edith M Janssen, Edward E Lemmens, +3 authors, Stephen P Schoenberger.
Nature, 2003 Feb 21; 421(6925). PMID: 12594515
Highly Cited.
CD8 T cell immunome analysis of Listeria monocytogenes.
Christian Kamm, Mojca Skoberne, Gernot Geginat.
FEMS Immunol Med Microbiol, 2003 Mar 22; 35(3). PMID: 12648842
IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection.
Sing Sing Way, Colin Havenar-Daughton, +2 authors, Kaja Murali-Krishna.
J Immunol, 2007 Mar 21; 178(7). PMID: 17372008    Free PMC article.
A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.
Nural N Orgun, Sing Sing Way.
Microb Pathog, 2007 Sep 25; 44(2). PMID: 17888620    Free PMC article.
Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains.
Peter Lauer, Bill Hanson, +9 authors, Thomas W Dubensky.
Infect Immun, 2008 Jun 11; 76(8). PMID: 18541651    Free PMC article.
Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature.
Paulo Cesar Maciag, Matthew M Seavey, +2 authors, Yvonne Paterson.
Cancer Res, 2008 Oct 03; 68(19). PMID: 18829565    Free PMC article.
KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity.
Mojca Skoberne, Alice Yewdall, +9 authors, Nina Bhardwaj.
J Clin Invest, 2008 Nov 27; 118(12). PMID: 19033668    Free PMC article.
Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.
Justin Skoble, John W Beaber, +9 authors, Thomas W Dubensky.
Infect Immun, 2009 Jan 27; 77(4). PMID: 19168734    Free PMC article.
Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria.
Keith S Bahjat, Nicole Meyer-Morse, +4 authors, Daniel A Portnoy.
PLoS Pathog, 2009 Sep 05; 5(9). PMID: 19730694    Free PMC article.
Dendritic cells inhibit the progression of Listeria monocytogenes intracellular infection by retaining bacteria in major histocompatibility complex class II-rich phagosomes and by limiting cytosolic growth.
Marlena M Westcott, Curtis J Henry, Jacqueline E Amis, Elizabeth M Hiltbold.
Infect Immun, 2010 Apr 21; 78(7). PMID: 20404078    Free PMC article.
Priming of protective anti-Listeria monocytogenes memory CD8+ T cells requires a functional SecA2 secretion system.
Massilva Rahmoun, Marilyn Gros, +6 authors, Grégoire Lauvau.
Infect Immun, 2011 Mar 16; 79(6). PMID: 21402759    Free PMC article.
Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo.
L M Mitchell, K L Brzoza-Lewis, +3 authors, E M Hiltbold.
Cell Immunol, 2011 Apr 05; 268(2). PMID: 21457950    Free PMC article.
Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.
Yujun Huang, Yunji Park, +12 authors, Hilde Cheroutre.
Nat Immunol, 2011 Oct 04; 12(11). PMID: 21964609    Free PMC article.
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Admar Verschoor, Michael Neuenhahn, +8 authors, Dirk H Busch.
Nat Immunol, 2011 Nov 01; 12(12). PMID: 22037602
A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction.
Dung T Le, Dirk G Brockstedt, +19 authors, Daniel A Laheru.
Clin Cancer Res, 2011 Dec 08; 18(3). PMID: 22147941    Free PMC article.
Highly Cited.
CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells.
Mélissa Mathieu, Natacha Cotta-Grand, +3 authors, Nathalie Labrecque.
PLoS One, 2012 Feb 01; 7(1). PMID: 22291907    Free PMC article.
Protective immunity to Listeria monocytogenes infection mediated by recombinant Listeria innocua harboring the VGC locus.
Walid Mohamed, Shneh Sethi, +2 authors, Trinad Chakraborty.
PLoS One, 2012 Apr 27; 7(4). PMID: 22536395    Free PMC article.
Clinical development of Listeria monocytogenes-based immunotherapies.
Dung T Le, Thomas W Dubenksy, Dirk G Brockstedt.
Semin Oncol, 2012 May 19; 39(3). PMID: 22595054    Free PMC article.
Review.
Cancer immunotherapy: a paradigm shift for prostate cancer treatment.
Dev Karan, Jeffrey M Holzbeierlein, Peter Van Veldhuizen, J Brantley Thrasher.
Nat Rev Urol, 2012 May 30; 9(7). PMID: 22641164
Review.
Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.
Matthew A Williams, Rebecca L Schmidt, Laurel L Lenz.
Trends Immunol, 2012 Jun 09; 33(10). PMID: 22677184    Free PMC article.
Review.
Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance.
Jared H Rowe, James M Ertelt, Lijun Xin, Sing Sing Way.
PLoS Pathog, 2012 Aug 24; 8(8). PMID: 22916020    Free PMC article.
A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion.
Jessica A Shugart, Shelly Bambina, +2 authors, Keith S Bahjat.
PLoS One, 2013 May 30; 8(5). PMID: 23717671    Free PMC article.
Inflammasome-mediated inhibition of Listeria monocytogenes-stimulated immunity is independent of myelomonocytic function.
Cassandra R Williams, Michael L Dustin, John-Demian Sauer.
PLoS One, 2013 Dec 19; 8(12). PMID: 24349458    Free PMC article.
STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes.
Kristina A Archer, Juliana Durack, Daniel A Portnoy.
PLoS Pathog, 2014 Jan 07; 10(1). PMID: 24391507    Free PMC article.
Highly Cited.
Vaccine therapy for pancreatic cancer.
Bulent Salman, Donger Zhou, +2 authors, Lei Zheng.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498551    Free PMC article.
Review.
Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin.
Aline Dupont, Fatima Mohamed, +14 authors, Cordula Stover.
Med Microbiol Immunol, 2014 Apr 15; 203(4). PMID: 24728387    Free PMC article.
Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants.
Thomas W Dubensky, David B Kanne, Meredith L Leong.
Ther Adv Vaccines, 2014 Apr 24; 1(4). PMID: 24757520    Free PMC article.
Review.
Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.
Patrick H Lizotte, Jason R Baird, +4 authors, Steven N Fiering.
Oncoimmunology, 2014 Aug 02; 3. PMID: 25083323    Free PMC article.
Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection.
Julianne M Zickovich, Susan I Meyer, Hideo Yagita, Joshua J Obar.
PLoS One, 2014 Aug 29; 9(8). PMID: 25166494    Free PMC article.
Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy.
Dayna R Clark, Vandana Chaturvedi, +4 authors, Sing Sing Way.
Cell Mol Immunol, 2014 Sep 23; 11(6). PMID: 25242275    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.
Alejandro F Alice, Gwen Kramer, +4 authors, Marka R Crittenden.
J Immunol, 2017 Nov 19; 200(1). PMID: 29150567    Free PMC article.
Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity.
Courtney E McDougal, John-Demian Sauer.
Pathogens, 2018 Jan 13; 7(1). PMID: 29324702    Free PMC article.
Review.
Animal and Human Tissue Models of Vertical Listeria monocytogenes Transmission and Implications for Other Pregnancy-Associated Infections.
David E Lowe, Jennifer R Robbins, Anna I Bakardjiev.
Infect Immun, 2018 Feb 28; 86(6). PMID: 29483290    Free PMC article.
Review.
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress.
John C Flickinger, Ulrich Rodeck, Adam E Snook.
Vaccines (Basel), 2018 Jul 26; 6(3). PMID: 30044426    Free PMC article.
Review.
The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.
Dave Maurice De Sousa, Frédéric Duval, +2 authors, Nathalie Labrecque.
PLoS One, 2019 Apr 06; 14(4). PMID: 30951556    Free PMC article.
Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?
Alfredo Chávez-Arroyo, Daniel A Portnoy.
Cell Microbiol, 2020 Mar 19; 22(4). PMID: 32185899    Free PMC article.
Review.
TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes.
Brittney N Nguyen, Alfredo Chávez-Arroyo, +3 authors, Daniel A Portnoy.
PLoS Pathog, 2020 Jul 08; 16(7). PMID: 32634175    Free PMC article.
Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3.
Livia Odagiu, Salix Boulet, +3 authors, Nathalie Labrecque.
Proc Natl Acad Sci U S A, 2020 Sep 12; 117(39). PMID: 32913051    Free PMC article.
Listeria monocytogenes cancer vaccines: bridging innate and adaptive immunity.
Zachary T Morrow, Zachary M Powers, John-Demian Sauer.
Curr Clin Microbiol Rep, 2020 Oct 20; 6(4). PMID: 33072493    Free PMC article.
Mechanistic diversity in MHC class I antigen recognition.
Camila R R Barbosa, Justin Barton, Adrian J Shepherd, Michele Mishto.
Biochem J, 2021 Dec 24; 478(24). PMID: 34940832    Free PMC article.
Review.