Journal Article
. 2006 Sep;98(17).
doi: 10.1093/jnci/djj329.

Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

Marc Buyse 1 Sherene Loi  Laura van't Veer  Giuseppe Viale  Mauro Delorenzi  Annuska M Glas  Mahasti Saghatchian d'Assignies  Jonas Bergh  Rosette Lidereau  Paul Ellis  Adrian Harris  Jan Bogaerts  Patrick Therasse  Arno Floore  Mohamed Amakrane  Fanny Piette  Emiel Rutgers  Christos Sotiriou  Fatima Cardoso  Martine J Piccart  TRANSBIG Consortium  
Affiliations
  • PMID: 16954471
  •     328 citations

Abstract

Background: A 70-gene signature was previously shown to have prognostic value in patients with node-negative breast cancer. Our goal was to validate the signature in an independent group of patients.

Methods: Patients (n = 307, with 137 events after a median follow-up of 13.6 years) from five European centers were divided into high- and low-risk groups based on the gene signature classification and on clinical risk classifications. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis-free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by Adjuvant! software, was greater than 88% (for estrogen receptor [ER]-positive patients) or 92% (for ER-negative patients). Hazard ratios (HRs) were estimated to compare time to distant metastases, disease-free survival, and overall survival in high- versus low-risk groups.

Results: The 70-gene signature outperformed the clinicopathologic risk assessment in predicting all endpoints. For time to distant metastases, the gene signature yielded HR = 2.32 (95% confidence interval [CI] = 1.35 to 4.00) without adjustment for clinical risk and hazard ratios ranging from 2.13 to 2.15 after adjustment for various estimates of clinical risk; clinicopathologic risk using Adjuvant! software yielded an unadjusted HR = 1.68 (95% CI = 0.92 to 3.07). For overall survival, the gene signature yielded an unadjusted HR = 2.79 (95% CI = 1.60 to 4.87) and adjusted hazard ratios ranging from 2.63 to 2.89; clinicopathologic risk yielded an unadjusted HR = 1.67 (95% CI = 0.93 to 2.98). For patients in the gene signature high-risk group, 10-year overall survival was 0.69 for patients in both the low- and high-clinical risk groups; for patients in the gene signature low-risk group, the 10-year survival rates were 0.88 and 0.89, respectively.

Conclusions: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer.

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Michael L Maitland, Richard L Schilsky.
CA Cancer J Clin, 2011 Oct 29; 61(6). PMID: 22034206    Free PMC article.
Lack of sufficiently strong informative features limits the potential of gene expression analysis as predictive tool for many clinical classification problems.
Kenneth R Hess, Caimiao Wei, +3 authors, Lajos Pusztai.
BMC Bioinformatics, 2011 Dec 03; 12. PMID: 22132775    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
Early developments in gene-expression profiling of breast tumors: potential for increasing black-white patient disparities in breast cancer outcomes?
Donna H Odierna, Aimee Afable-Munsuz, +5 authors, Ninez A Ponce.
Per Med, 2011 Dec 23; 8(6). PMID: 22190978    Free PMC article.
Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657).
Laura J Esserman, Donald A Berry, +32 authors, I-SPY 1 TRIAL Investigators.
Breast Cancer Res Treat, 2011 Dec 27; 132(3). PMID: 22198468    Free PMC article.
Highly Cited.
Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer.
E Fountzilas, K Markou, +8 authors, D Spentzos.
Ann Oncol, 2012 Jan 06; 23(8). PMID: 22219018    Free PMC article.
Gene expression profiling: changing face of breast cancer classification and management.
Robert Wesolowski, Bhuvaneswari Ramaswamy.
Gene Expr, 2012 Jan 25; 15(3). PMID: 22268293    Free PMC article.
Review.
A gene signature for predicting outcome in patients with basal-like breast cancer.
Robin M Hallett, Anna Dvorkin-Gheva, Anita Bane, John A Hassell.
Sci Rep, 2012 Feb 23; 2. PMID: 22355741    Free PMC article.
Application of microarray in breast cancer: An overview.
Rajnish Kumar, Anju Sharma, Rajesh Kumar Tiwari.
J Pharm Bioallied Sci, 2012 Mar 01; 4(1). PMID: 22368395    Free PMC article.
Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy.
Lasse Folkersen, Jonas Persson, +5 authors, Gabrielle Paulsson-Berne.
Mol Med, 2012 Mar 01; 18. PMID: 22371308    Free PMC article.
The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.
Marian Grade, Hendrik A Wolff, Jochen Gaedcke, B Michael Ghadimi.
Langenbecks Arch Surg, 2012 Mar 03; 397(4). PMID: 22382702    Free PMC article.
Review.
Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
Shannon Puhalla, Saveri Bhattacharya, Nancy E Davidson.
Mol Oncol, 2012 Mar 13; 6(2). PMID: 22406404    Free PMC article.
Review.
Patients with positive axillary lymph nodes: how to use genomic assays.
Ruta Rao.
Curr Treat Options Oncol, 2012 Mar 20; 13(2). PMID: 22426945
Toward individualized breast cancer therapy: translating biological concepts to the bedside.
Gabriel N Hortobagyi.
Oncologist, 2012 Apr 05; 17(4). PMID: 22474069    Free PMC article.
Molecular signatures from omics data: from chaos to consensus.
Jaeyun Sung, Yuliang Wang, +2 authors, Nathan D Price.
Biotechnol J, 2012 Apr 25; 7(8). PMID: 22528809    Free PMC article.
Review.
Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen.
A Prat, J S Parker, +9 authors, C M Perou.
Ann Oncol, 2012 Apr 26; 23(11). PMID: 22532584    Free PMC article.
Predicting glioblastoma prognosis networks using weighted gene co-expression network analysis on TCGA data.
Yang Xiang, Cun-Quan Zhang, Kun Huang.
BMC Bioinformatics, 2012 May 02; 13 Suppl 2. PMID: 22536863    Free PMC article.
The 70-Gene Signature as Prognostic Factor for Elderly Women with Hormone Receptor-Positive, HER2-Negative Breast Cancer.
Steffi Hartmann, Bernd Gerber, +2 authors, Toralf Reimer.
Breast Care (Basel), 2012 May 04; 7(1). PMID: 22553468    Free PMC article.
Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes.
Christof Winter, Glen Kristiansen, +18 authors, Robert Grützmann.
PLoS Comput Biol, 2012 May 23; 8(5). PMID: 22615549    Free PMC article.
Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.
Sylvie M Noordermeer, Marloes Wennemers, +6 authors, Bert A van der Reijden.
Breast Cancer Res Treat, 2012 Jun 19; 135(1). PMID: 22706632    Free PMC article.
Proteomic studies in breast cancer (Review).
Xian-Ju Qin, Bruce X Ling.
Oncol Lett, 2012 Jun 29; 3(4). PMID: 22740985    Free PMC article.
Signatures of tumor-immune interactions as biomarkers for breast cancer prognosis.
Masoud H Manjili, Kayvan Najarian, Xiang-Yang Wang.
Future Oncol, 2012 Jul 07; 8(6). PMID: 22764768    Free PMC article.
Review.
Development of novel breast cancer recurrence prediction model using support vector machine.
Woojae Kim, Ku Sang Kim, +5 authors, Rae Woong Park.
J Breast Cancer, 2012 Jul 19; 15(2). PMID: 22807942    Free PMC article.
Assessment of performance of survival prediction models for cancer prognosis.
Hung-Chia Chen, Ralph L Kodell, Kuang Fu Cheng, James J Chen.
BMC Med Res Methodol, 2012 Jul 25; 12. PMID: 22824262    Free PMC article.
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity.
Aaron Boudreau, Laura J van't Veer, Mina J Bissell.
Cell Adh Migr, 2012 Aug 07; 6(3). PMID: 22863741    Free PMC article.
Review.
The non-crosslinking fixative RCL2®-CS100 is compatible with both pathology diagnosis and molecular analyses.
Florence Boissière-Michot, Amélie Denouël, +5 authors, Frédéric Bibeau.
Pathol Oncol Res, 2012 Aug 16; 19(1). PMID: 22893391
Scenario drafting to anticipate future developments in technology assessment.
Valesca P Retèl, Manuela A Joore, +2 authors, Wim H van Harten.
BMC Res Notes, 2012 Aug 17; 5. PMID: 22894140    Free PMC article.
Weighted frequent gene co-expression network mining to identify genes involved in genome stability.
Jie Zhang, Kewei Lu, +8 authors, Kun Huang.
PLoS Comput Biol, 2012 Sep 08; 8(8). PMID: 22956898    Free PMC article.
Future directions in cancer prevention.
Asad Umar, Barbara K Dunn, Peter Greenwald.
Nat Rev Cancer, 2012 Nov 16; 12(12). PMID: 23151603
Review.
A systematic evaluation of multi-gene predictors for the pathological response of breast cancer patients to chemotherapy.
Kui Shen, Nan Song, +6 authors, Jae K Lee.
PLoS One, 2012 Nov 28; 7(11). PMID: 23185353    Free PMC article.
Prediction and prognosis: impact of gene expression profiling in personalized treatment of breast cancer patients.
Michael R Mallmann, Andrea Staratschek-Jox, +5 authors, Joachim L Schultze.
EPMA J, 2010 Sep 01; 1(3). PMID: 23199086    Free PMC article.
A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease.
Matthew P Wagoner, Avtar Roopra.
BMC Genomics, 2012 Dec 12; 13. PMID: 23216891    Free PMC article.
Gene expression profiles for predicting metastasis in breast cancer: a cross-study comparison of classification methods.
Mark Burton, Mads Thomassen, Qihua Tan, Torben A Kruse.
ScientificWorldJournal, 2012 Dec 20; 2012. PMID: 23251101    Free PMC article.
Statistical aspects of omics data analysis using the random compound covariate.
Pei-Fang Su, Xi Chen, Heidi Chen, Yu Shyr.
BMC Syst Biol, 2013 Jan 11; 6 Suppl 3. PMID: 23281681    Free PMC article.
Prediction of breast cancer metastasis by gene expression profiles: a comparison of metagenes and single genes.
Mark Burton, Mads Thomassen, Qihua Tan, Torben A Kruse.
Cancer Inform, 2013 Jan 11; 11. PMID: 23304070    Free PMC article.
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
H A Azim, S Michiels, +9 authors, C Swanton.
Ann Oncol, 2013 Jan 23; 24(3). PMID: 23337633    Free PMC article.
Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.
K Kai, T Iwamoto, +10 authors, N T Ueno.
Oncogene, 2013 Feb 05; 33(4). PMID: 23376849    Free PMC article.
Translating metastasis-related biomarkers to the clinic--progress and pitfalls.
François-Clément Bidard, Jean-Yves Pierga, Jean-Charles Soria, Jean Paul Thiery.
Nat Rev Clin Oncol, 2013 Feb 06; 10(3). PMID: 23381003
Review.
A data similarity-based strategy for meta-analysis of transcriptional profiles in cancer.
Qingchao Qiu, Pengcheng Lu, +6 authors, Yajun Yi.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383020    Free PMC article.
Treating breast cancer in the 21st century: emerging biological therapies.
Gabriel Tinoco, Sean Warsch, +2 authors, Alberto J Montero.
J Cancer, 2013 Feb 07; 4(2). PMID: 23386910    Free PMC article.
Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?
Olga Golubnitschaja, Kristina Yeghiazaryan, +5 authors, Hans H Schild.
EPMA J, 2013 Feb 20; 4(1). PMID: 23418957    Free PMC article.
PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer.
Miguel Martín, Aleix Prat, +24 authors, Philip S Bernard.
Breast Cancer Res Treat, 2013 Feb 21; 138(2). PMID: 23423445    Free PMC article.
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.
Christophe J Desmet, Tristan Gallenne, +17 authors, Daniel S Peeper.
Proc Natl Acad Sci U S A, 2013 Mar 14; 110(13). PMID: 23483055    Free PMC article.
Highly Cited.
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways.
Margit L H Riis, Xi Zhao, +6 authors, Vessela N Kristensen.
ISRN Oncol, 2013 Mar 28; 2013. PMID: 23533813    Free PMC article.
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.
Patrick C O Leary, Sarah A Penny, +12 authors, William M Gallagher.
BMC Cancer, 2013 Apr 04; 13. PMID: 23547718    Free PMC article.
Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.
Ke-Da Yu, Rui Zhu, +11 authors, Jenny C Chang.
Clin Cancer Res, 2013 Apr 04; 19(10). PMID: 23549873    Free PMC article.
Gene expression profiling in breast cancer.
Belisario A Arango, Celine L Rivera, Stefan Glück.
Am J Transl Res, 2013 Apr 11; 5(2). PMID: 23573359    Free PMC article.
Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.
Srikanth Nagalla, Jeff W Chou, +9 authors, Lance D Miller.
Genome Biol, 2013 Apr 27; 14(4). PMID: 23618380    Free PMC article.
Highly Cited.
Identification and validation of a new set of five genes for prediction of risk in early breast cancer.
Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi.
Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477    Free PMC article.
A simple and reproducible breast cancer prognostic test.
Luigi Marchionni, Bahman Afsari, Donald Geman, Jeffrey T Leek.
BMC Genomics, 2013 May 21; 14. PMID: 23682826    Free PMC article.
Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses.
Roman Rouzier, Paolo Pronzato, +3 authors, William J Valentine.
Breast Cancer Res Treat, 2013 Jun 01; 139(3). PMID: 23722312    Free PMC article.
Systematic Review.
Recognising the benefits and harms of breast cancer screening: an opportunity to target improvement.
C O'Donoghue, L Esserman.
Br J Cancer, 2013 Jun 08; 108(11). PMID: 23744278    Free PMC article.
Association between genomic recurrence risk and well-being among breast cancer patients.
Valesca P Retèl, Catharina G M Groothuis-Oudshoorn, +3 authors, Wim H van Harten.
BMC Cancer, 2013 Jun 20; 13. PMID: 23777535    Free PMC article.
Interrogating differences in expression of targeted gene sets to predict breast cancer outcome.
Sarah A Andres, Guy N Brock, James L Wittliff.
BMC Cancer, 2013 Jul 04; 13. PMID: 23819905    Free PMC article.
A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences.
Lorenza Mittempergher, Mahasti Saghatchian, +9 authors, Laura J van't Veer.
Mol Oncol, 2013 Aug 06; 7(5). PMID: 23910573    Free PMC article.
The impact of the Oncotype Dx breast cancer assay in clinical practice: a systematic review and meta-analysis.
Josh J Carlson, Joshua A Roth.
Breast Cancer Res Treat, 2013 Aug 27; 141(1). PMID: 23974828    Free PMC article.
Highly Cited. Systematic Review.
Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine.
Ashley G Rivenbark, Siobhan M O'Connor, William B Coleman.
Am J Pathol, 2013 Sep 03; 183(4). PMID: 23993780    Free PMC article.
Review.
TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
Xiaoping Wang, Hitomi Saso, +10 authors, Naoto T Ueno.
Cancer Res, 2013 Sep 10; 73(21). PMID: 24014597    Free PMC article.
Analytical Study of Performance of Linear Discriminant Analysis in Stochastic Settings.
Amin Zollanvari, Jianping Hua, Edward R Dougherty.
Pattern Recognit, 2013 Sep 17; 46(11). PMID: 24039299    Free PMC article.
Validation of a proliferation-based expression signature as prognostic marker in early stage lung adenocarcinoma.
Ignacio I Wistuba, Carmen Behrens, +16 authors, Edward S Kim.
Clin Cancer Res, 2013 Sep 21; 19(22). PMID: 24048333    Free PMC article.
Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.
Rumiko Kinoshita, Jin-Min Nam, +13 authors, Hisataka Sabe.
PLoS One, 2013 Oct 12; 8(10). PMID: 24116160    Free PMC article.
A pathway-based data integration framework for prediction of disease progression.
José A Seoane, Ian N M Day, Tom R Gaunt, Colin Campbell.
Bioinformatics, 2013 Oct 29; 30(6). PMID: 24162466    Free PMC article.
PROGgene: gene expression based survival analysis web application for multiple cancers.
Chirayu Pankaj Goswami, Harikrishna Nakshatri.
J Clin Bioinforma, 2013 Oct 30; 3(1). PMID: 24165311    Free PMC article.
Highly Cited.
An optimized five-gene multi-platform predictor of hormone receptor negative and triple negative breast cancer metastatic risk.
Christina Yau, John Sninsky, +9 authors, Christopher C Benz.
Breast Cancer Res, 2013 Nov 01; 15(5). PMID: 24172169    Free PMC article.
Biological resonance for cancer metastasis, a new hypothesis based on comparisons between primary cancers and metastases.
Dongwei Gao, Sha Li.
Cancer Microenviron, 2013 Nov 12; 6(3). PMID: 24214411    Free PMC article.
Molecular profiling for breast cancer: a comprehensive review.
Muaiad Kittaneh, Alberto J Montero, Stefan Glück.
Biomark Cancer, 2013 Nov 20; 5. PMID: 24250234    Free PMC article.
Review.
An unmet need: tailoring extended adjuvant endocrine therapy.
G Bianchini, L Gianni.
Br J Cancer, 2013 Nov 21; 109(12). PMID: 24253504    Free PMC article.
Construction and analysis of multiparameter prognostic models for melanoma outcome.
Bonnie E Gould Rothberg, David L Rimm.
Methods Mol Biol, 2013 Nov 22; 1102. PMID: 24258982    Free PMC article.
Systematic Review.
MammaPrint Feasibility in a Large Tertiary Urban Medical Center: An Initial Experience.
C Francisco Espinel, Shaughn Keating, +4 authors, Sheldon Feldman.
Scientifica (Cairo), 2012 Jan 01; 2012. PMID: 24278759    Free PMC article.
Prognostic discrimination using a 70-gene signature among patients with estrogen receptor-positive breast cancer and an intermediate 21-gene recurrence score.
Sung Gwe Ahn, Hak Min Lee, +5 authors, In-Sun Chu.
Int J Mol Sci, 2013 Dec 07; 14(12). PMID: 24304542    Free PMC article.
Network Based Prediction Model for Genomics Data Analysis.
Ying Huang, Pei Wang.
Stat Biosci, 2012 Apr 01; 4(1). PMID: 24348880    Free PMC article.
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Anna Tessari, Dario Palmieri, Serena Di Cosimo.
Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841    Free PMC article.
Review.
Breast Cancer Biomarkers: Utility in Clinical Practice.
Fanny Le Du, Naoto T Ueno, Ana M Gonzalez-Angulo.
Curr Breast Cancer Rep, 2014 Jan 15; 5(4). PMID: 24416469    Free PMC article.
Long-term impact of the 70-gene signature on breast cancer outcome.
C A Drukker, H van Tinteren, +4 authors, L J Van't Veer.
Breast Cancer Res Treat, 2014 Jan 22; 143(3). PMID: 24445566    Free PMC article.
Mammographic screening detects low-risk tumor biology breast cancers.
C A Drukker, M K Schmidt, +8 authors, L J Van't Veer.
Breast Cancer Res Treat, 2014 Jan 29; 144(1). PMID: 24469641    Free PMC article.
Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types.
Yang Yang, Leng Han, +3 authors, Han Liang.
Nat Commun, 2014 Feb 04; 5. PMID: 24488081    Free PMC article.
Highly Cited.
Epithelial-mesenchymal transition-associated secretory phenotype predicts survival in lung cancer patients.
Ajaya Kumar Reka, Guoan Chen, +7 authors, Venkateshwar G Keshamouni.
Carcinogenesis, 2014 Feb 11; 35(6). PMID: 24510113    Free PMC article.
Genomic profiling in luminal breast cancer.
Oleg Gluz, Daniel Hofmann, +3 authors, Nadia Harbeck.
Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550749    Free PMC article.
Review.
Good practice guidelines for biomarker discovery from array data: a case study for breast cancer prognosis.
Jie Cheng, Joel Greshock, +3 authors, Kwan Lee.
BMC Syst Biol, 2014 Feb 26; 7 Suppl 4. PMID: 24565120    Free PMC article.
Application of a decision analytic framework for adoption of clinical trial results: are the data regarding TARGIT-A IORT ready for prime time?
L J Esserman, M D Alvarado, +5 authors, E M Ozanne.
Breast Cancer Res Treat, 2014 Mar 04; 144(2). PMID: 24584875    Free PMC article.
Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer.
Kristin Jonsdottir, Jörg Assmus, +4 authors, Emiel A M Janssen.
PLoS One, 2014 Mar 07; 9(3). PMID: 24599057    Free PMC article.
Recent advances in the molecular characterization of circulating tumor cells.
Lori E Lowes, Alison L Allan.
Cancers (Basel), 2014 Mar 19; 6(1). PMID: 24633084    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.
F Al-Ejeh, P T Simpson, +12 authors, K K Khanna.
Oncogenesis, 2014 Apr 23; 3. PMID: 24752235    Free PMC article.
Optimized outcome prediction in breast cancer by combining the 70-gene signature with clinical risk prediction algorithms.
C A Drukker, M V Nijenhuis, +10 authors, S C Linn.
Breast Cancer Res Treat, 2014 Apr 25; 145(3). PMID: 24760482    Free PMC article.
Patients' perceptions of gene expression profiling in breast cancer treatment decisions.
Y Bombard, L Rozmovits, +3 authors, D A Marshall.
Curr Oncol, 2014 Apr 26; 21(2). PMID: 24764705    Free PMC article.
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility.
P Sinn, S Aulmann, +6 authors, A Schneeweiss.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(9). PMID: 24771945    Free PMC article.
Addressing overdiagnosis and overtreatment in cancer: a prescription for change.
Laura J Esserman, Ian M Thompson, +10 authors, Sudhir Srivastava.
Lancet Oncol, 2014 May 09; 15(6). PMID: 24807866    Free PMC article.
Highly Cited.
Predictive and prognostic value of the 21-gene recurrence score in hormone receptor-positive, node-positive breast cancer.
Adam M Brufsky.
Am J Clin Oncol, 2014 May 24; 37(4). PMID: 24853663    Free PMC article.
Systematic Review.
Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.
Thomas E Rohan, Xiaonan Xue, +10 authors, Joan G Jones.
J Natl Cancer Inst, 2014 Jun 05; 106(8). PMID: 24895374    Free PMC article.
Highly Cited.
Modern Risk Assessment for Individualizing Treatment Concepts in Early-stage Breast Cancer.
Alex Farr, Rachel Wuerstlein, +2 authors, Nadia Harbeck.
Rev Obstet Gynecol, 2013 Jan 01; 6(3-4). PMID: 24920978    Free PMC article.
Access to personalized medicine: factors influencing the use and value of gene expression profiling in breast cancer treatment.
Y Bombard, L Rozmovits, +3 authors, D A Marshall.
Curr Oncol, 2014 Jun 19; 21(3). PMID: 24940102    Free PMC article.
The multigene signature MammaPrint impacts on multidisciplinary team decisions in ER+, HER2- early breast cancer.
R Exner, Z Bago-Horvath, +9 authors, P Dubsky.
Br J Cancer, 2014 Jul 09; 111(5). PMID: 25003667    Free PMC article.
Ductal Carcinoma In Situ of the Breast: Evaluating the Role of Radiation Therapy in the Management and Attempts to Identify Low-risk Patients.
Chirag Shah, Frank A Vicini, +6 authors, Neal Goldstein.
Am J Clin Oncol, 2014 Jul 19; 38(5). PMID: 25036472    Free PMC article.
Review.
Diagnostic tests based on gene expression profile in breast cancer: from background to clinical use.
Laura Zanotti, Alberto Bottini, +2 authors, Maria Rosa Cappelletti.
Tumour Biol, 2014 Jul 23; 35(9). PMID: 25048969
Review.
Molecular subtyping predicts pathologic tumor response in early-stage breast cancer treated with neoadjuvant docetaxel plus capecitabine with or without trastuzumab chemotherapy.
Soley Bayraktar, Melanie Royce, +2 authors, Stefan Glück.
Med Oncol, 2014 Sep 05; 31(10). PMID: 25186065
Genome-based risk prediction for early stage breast cancer.
Christina Adaniel, Komal Jhaveri, Adriana Heguy, Francisco J Esteva.
Oncologist, 2014 Sep 05; 19(10). PMID: 25187476    Free PMC article.
Review.
Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: novel therapeutic strategy for aggressive breast cancers.
Suruchi Mittal, Ankur Sharma, +4 authors, Annapoorni Rangarajan.
Mol Cancer Ther, 2014 Sep 26; 13(12). PMID: 25253780    Free PMC article.
Time dependence of biomarkers: non-proportional effects of immunohistochemical panels predicting relapse risk in early breast cancer.
J Stephen, G Murray, +13 authors, J M S Bartlett.
Br J Cancer, 2014 Oct 15; 111(12). PMID: 25314051    Free PMC article.
Added predictive value of omics data: specific issues related to validation illustrated by two case studies.
Riccardo De Bin, Tobias Herold, Anne-Laure Boulesteix.
BMC Med Res Methodol, 2014 Oct 30; 14. PMID: 25352096    Free PMC article.
From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action.
Andreas Heinzel, Paul Perco, +3 authors, Bernd Mayer.
Front Cell Dev Biol, 2014 Nov 05; 2. PMID: 25364744    Free PMC article.
Prediction of individual response to anticancer therapy: historical and future perspectives.
Florian T Unger, Irene Witte, Kerstin A David.
Cell Mol Life Sci, 2014 Nov 13; 72(4). PMID: 25387856    Free PMC article.
Review.
Role of MTA2 in human cancer.
Kyle R Covington, Suzanne A W Fuqua.
Cancer Metastasis Rev, 2014 Nov 15; 33(4). PMID: 25394532    Free PMC article.
Review.
Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.
Gregory Weitsman, Katherine Lawler, +18 authors, Tony Ng.
Biochem Soc Trans, 2014 Nov 18; 42(6). PMID: 25399560    Free PMC article.
Review.
The value of multigene predictors of clinical outcome in breast cancer: an analysis of the evidence.
Amalia M Issa, Vivek S Chaudhari, Gary E Marchant.
Expert Rev Mol Diagn, 2014 Dec 06; 15(2). PMID: 25479414    Free PMC article.
Review.
Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas.
Lars Olsen, Benito Campos, +3 authors, Vladimir Brusic.
BMC Med Genomics, 2014 Dec 19; 7 Suppl 3. PMID: 25521819    Free PMC article.
A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis.
Sajjad Rafiq, Sofia Khan, +9 authors, Diana Eccles.
PLoS One, 2014 Dec 20; 9(12). PMID: 25526632    Free PMC article.
Understanding the economic value of molecular diagnostic tests: case studies and lessons learned.
Adrian Towse, Diego Ossa, +2 authors, Louis Garrison.
J Pers Med, 2013 Jan 01; 3(4). PMID: 25562729    Free PMC article.
Review.
Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer.
Purificacion Estevez-Garcia, Fernando Rivera, +8 authors, Rocio Garcia-Carbonero.
Oncotarget, 2015 Mar 03; 6(8). PMID: 25730906    Free PMC article.
Markers for the identification of late breast cancer recurrence.
Ivana Sestak, Jack Cuzick.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848913    Free PMC article.
Review.
Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers.
Kristina P Sørensen, Mads Thomassen, +5 authors, Torben A Kruse.
Breast Cancer Res, 2015 Apr 19; 17. PMID: 25887545    Free PMC article.
The UZ Leuven Policy for Extended Adjuvant Anti-estrogen Therapy in Women With Early Estrogen Receptor-Positive Breast Cancer.
Kathleen Van Asten, An Poppe, +4 authors, Patrick Neven.
Curr Treat Options Oncol, 2015 Jun 03; 16(7). PMID: 26031545
Review.
Application of a 70-Gene Expression Profile to Japanese Breast Cancer Patients.
Hideo Shimizu, Yoshiya Horimoto, +14 authors, Mitsue Saito.
Breast Care (Basel), 2015 Jul 22; 10(2). PMID: 26195940    Free PMC article.
Optimal approach in early breast cancer: Adjuvant and neoadjuvant treatment.
J Ribeiro, B Sousa, F Cardoso.
EJC Suppl, 2013 Sep 01; 11(2). PMID: 26217109    Free PMC article.
Review.
Combining large number of weak biomarkers based on AUC.
Li Yan, Lili Tian, Song Liu.
Stat Med, 2015 Aug 01; 34(29). PMID: 26227901    Free PMC article.
Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.
Siker Kimbung, Anikó Kovács, +10 authors, Ingrid Hedenfalk.
Oncotarget, 2015 Sep 17; 6(32). PMID: 26375671    Free PMC article.
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BMJ Open, 2016 Jun 04; 6(6). PMID: 27256091    Free PMC article.
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Proc Natl Acad Sci U S A, 2017 Mar 03; 114(11). PMID: 28251929    Free PMC article.
Personalized chemotherapy selection for breast cancer using gene expression profiles.
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Breast Cancer (Dove Med Press), 2017 Apr 21; 9. PMID: 28424560    Free PMC article.
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