Review
. 2006 Oct; 59(10):1008-16.
doi: 10.1136/jcp.2005.035345.

Coeliac disease: an update for pathologists

B C Dickson 1 C J Streutker  R Chetty  
Affiliations
  • PMID: 17021129
  •     82 References
  •     81 citations

Abstract

Coeliac disease is the manifestation of an immune hypersensitivity reaction towards gluten and related proteins, in genetically predisposed people. Although the precise pathogenesis of this condition remains to be fully elucidated, it is probably multifactorial in origin. The diagnosis of coeliac disease has traditionally depended on intestinal biopsies alone; nowadays, the diagnosis has been expanded to include an array of serological markers. This review is intended to offer pathologists an update of the relevant history and immunopathology pertaining to coeliac disease and also to offer recommendations on the ongoing responsibilities of the pathologist in the diagnosis and reporting of coeliac disease.

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Am J Gastroenterol, 2016 Jan 06; 111(1). PMID: 26729543
Coeliac disease, mucosal change and IEL: doing what counts the best.
Michael N Marsh.
Gastroenterol Hepatol Bed Bench, 2016 Jan 09; 9(1). PMID: 26744607    Free PMC article.
HLA Profile of Celiac Disease among First-Degree Relatives from a Tertiary Care Center in North India.
Shilpy Singla, Praveen Kumar, +3 authors, Monisha Choudhury.
Indian J Pediatr, 2016 Jun 07; 83(11). PMID: 27264101
Maternal and perinatal conditions and the risk of developing celiac disease during childhood.
Fredinah Namatovu, Cecilia Olsson, +4 authors, Olof Sandström.
BMC Pediatr, 2016 Jun 09; 16. PMID: 27267234    Free PMC article.
The broad spectrum of celiac disease and gluten sensitive enteropathy.
Oana Mocan, Dan L Dumitraşcu.
Clujul Med, 2016 Aug 23; 89(3). PMID: 27547052    Free PMC article.
Review.
Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients.
Edward J Ciaccio, Govind Bhagat, Suzanne K Lewis, Peter H Green.
World J Gastrointest Endosc, 2016 Nov 03; 8(18). PMID: 27803772    Free PMC article.
Macrophage activation syndrome triggered by coeliac disease: a unique case report.
J Palman, J May, C Pilkington.
Pediatr Rheumatol Online J, 2016 Dec 13; 14(1). PMID: 27938384    Free PMC article.
Evolutionary Developments in Interpreting the  Gluten-Induced Mucosal Celiac Lesion: An  Archimedian Heuristic.
Michael N Marsh, Calvin J Heal.
Nutrients, 2017 Mar 08; 9(3). PMID: 28264483    Free PMC article.
Review.
Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy.
Jing Liu, Rebecca A Law, +3 authors, Courtney E W Sulentic.
Dig Liver Dis, 2017 May 06; 49(8). PMID: 28473300    Free PMC article.
Ultrasound capsule endoscopy: sounding out the future.
Benjamin F Cox, Fraser Stewart, +6 authors, Sandy Cochran.
Ann Transl Med, 2017 Jun 02; 5(9). PMID: 28567381    Free PMC article.
Coexistence of celiac disease & type 1 diabetes mellitus in children.
Preeti Singh, Anju Seth, Praveen Kumar, Sushma Sajjan.
Indian J Med Res, 2017 Jun 03; 145(1). PMID: 28574011    Free PMC article.
The identification of celiac disease in asymptomatic children: the Generation R Study.
Michelle Jansen, Menno van Zelm, +6 authors, Johanna Escher.
J Gastroenterol, 2017 Jun 08; 53(3). PMID: 28589338    Free PMC article.
Lymphocytic duodenitis or microscopic enteritis and gluten-related conditions: what needs to be explored?
Enzo Ierardi, Giuseppe Losurdo, +6 authors, Alfredo Di Leo.
Ann Gastroenterol, 2017 Jun 29; 30(4). PMID: 28655974    Free PMC article.
Review.
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation.
Kamran Rostami, Michael N Marsh, +38 authors, Amitabh Srivastava.
Gut, 2017 Sep 13; 66(12). PMID: 28893865    Free PMC article.
Comparison between digital and optical microscopy: Analysis in a mouse gut inflammation model.
Airton Pereira E Silva, Sylvia Maria Nicolau Campos, Isabelle Mazza Guimarães, Gerlinde Agate Platais Brasil Teixeira.
Biomed Rep, 2017 Sep 13; 7(3). PMID: 28894572    Free PMC article.
Celiac disease-related osteopathy among Saudi celiac patients: Are we adherent to recommendations?
Mona A Fouda.
Saudi J Gastroenterol, 2017 Sep 25; 23(5). PMID: 28937024    Free PMC article.
Environmental Enteric Dysfunction: A Case Definition for Intervention Trials.
Donna M Denno, Phillip I Tarr, James P Nataro.
Am J Trop Med Hyg, 2017 Oct 11; 97(6). PMID: 29016294    Free PMC article.
A Caucasian American patient with celiac disease diagnosed in Japan and successfully treated with a gluten-free diet.
Haruka Wada, Mari Hayashida, +13 authors, Tadakazu Hisamatsu.
Clin J Gastroenterol, 2017 Nov 03; 11(1). PMID: 29094324
Factors associated with number of duodenal samples obtained in suspected celiac disease.
Leonid Shamban, Serge Sorser, +7 authors, Peter H R Green.
Endosc Int Open, 2017 Dec 09; 5(12). PMID: 29218313    Free PMC article.
Psychiatric Comorbidity in Children and Adults with Gluten-Related Disorders: A Narrative Review.
Mahmoud Slim, Fernando Rico-Villademoros, Elena P Calandre.
Nutrients, 2018 Jul 11; 10(7). PMID: 29986423    Free PMC article.
Review.
Social and Emotional Fears and Worries Influencing the Quality of Life of Female Celiac Disease Patients Following a Gluten-Free Diet.
Wioleta Zysk, Dominika Głąbska, Dominika Guzek.
Nutrients, 2018 Oct 05; 10(10). PMID: 30282900    Free PMC article.
Can High Titres of Anti Tissue Transglutaminase Antibodies Reduce the Need for Intestinal Biopsy for Diagnosis of Celiac Disease?
Ekta Bansal, Navpreet Kaur, Naveen Mittal.
Indian J Clin Biochem, 2018 Oct 16; 33(4). PMID: 30319193    Free PMC article.
A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet.
Klaudia Feruś, Natalia Drabińska, Urszula Krupa-Kozak, Elżbieta Jarocka-Cyrta.
Nutrients, 2018 Nov 25; 10(11). PMID: 30469412    Free PMC article.
Assessing the Utility of Multiplexed Liquid Chromatography-Mass Spectrometry for Gluten Detection in Australian Breakfast Food Products.
Haili Li, Utpal Bose, +2 authors, Michelle Colgrave.
Molecules, 2019 Oct 17; 24(20). PMID: 31614625    Free PMC article.
The Use of Biopsy and "No-Biopsy" Approach for Diagnosing Paediatric Coeliac Disease in the Central European Region.
Petra Riznik, Márta Balogh, +19 authors, Jernej Dolinsek.
Gastroenterol Res Pract, 2019 Dec 13; 2019. PMID: 31827506    Free PMC article.
Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging.
Ching Lam, David S Sanders, +8 authors, Robin Spiller.
United European Gastroenterol J, 2019 Dec 17; 7(10). PMID: 31839961    Free PMC article.
Diagnosing coeliac disease: Out with the old and in with the new?
Richard Pg Charlesworth.
World J Gastroenterol, 2020 Jan 15; 26(1). PMID: 31933510    Free PMC article.
Review.
Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease.
Rachel Freire, Laura Ingano, +6 authors, Stefania Senger.
Sci Rep, 2019 May 09; 9(1). PMID: 31065051    Free PMC article.
A Cell Proliferation and Inflammatory Signature Is Induced by Lawsonia intracellularis Infection in Swine.
Fernando L Leite, Juan E Abrahante, +7 authors, Richard E Isaacson.
mBio, 2019 Jan 31; 10(1). PMID: 30696739    Free PMC article.
Relaxation of Extracellular Matrix Forces Directs Crypt Formation and Architecture in Intestinal Organoids.
Ella A Hushka, F Max Yavitt, +2 authors, Kristi S Anseth.
Adv Healthc Mater, 2020 Jan 21; 9(8). PMID: 31957249    Free PMC article.
Coexistence of Autoimmune Disorders and Type 1 Diabetes Mellitus in Children: An Observation from Western Part of India.
Balram Sharma, Hardeva R Nehara, +3 authors, Sandeep K Mathur.
Indian J Endocrinol Metab, 2019 Apr 25; 23(1). PMID: 31016148    Free PMC article.
Simultaneous analyses of carbohydrate-mediated serum GLP-1 and GLP-2 and duodenal receptor expression in children with and without celiac disease.
Marianna Rachmiel, Gilad Ben-Yehudah, Haim Shirin, Efrat Broide.
Therap Adv Gastroenterol, 2019 May 01; 12. PMID: 31037120    Free PMC article.
IgA nephropathy associated with coeliac disease.
Ireneusz Habura, Katarzyna Fiedorowicz, +3 authors, Andrzej Oko.
Cent Eur J Immunol, 2019 May 23; 44(1). PMID: 31114445    Free PMC article.
Celiac disease in Iranian irritable bowel syndrome patients; a systematic review and meta-analysis.
Milad Azami, Gholamreza Badfar, Ghobad Abangah, Leily Mahmoudi.
Gastroenterol Hepatol Bed Bench, 2019 Jun 14; 12(2). PMID: 31191832    Free PMC article.
Review.
Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort.
Marisa G Stahl, Fran Dong, +8 authors, Karl Mårild.
Scand J Gastroenterol, 2020 Sep 18; 55(11). PMID: 32941083    Free PMC article.
Unrecognised coeliac disease among men and women undergoing fertility treatment: A screening study.
Louise B Grode, Inge E Agerholm, +4 authors, Thomas M Jensen.
United European Gastroenterol J, 2018 Dec 24; 6(10). PMID: 30574318    Free PMC article.
The Phenotype of Celiac Disease Has Low Concordance between Siblings, Despite a Similar Distribution of HLA Haplotypes.
Saana Kauma, Katri Kaukinen, +6 authors, Kalle Kurppa.
Nutrients, 2019 Mar 03; 11(2). PMID: 30823533    Free PMC article.
Daily Life Restrictions are Common and Associated with Health Concerns and Dietary Challenges in Adult Celiac Disease Patients Diagnosed in Childhood.
Heini Leinonen, Laura Kivelä, +3 authors, Kalle Kurppa.
Nutrients, 2019 Jul 28; 11(8). PMID: 31349675    Free PMC article.
Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.
Laura Airaksinen, Pilvi Laurikka, +5 authors, Katri Lindfors.
Nutrients, 2020 Dec 16; 12(12). PMID: 33317091    Free PMC article.
Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols.
Charlene B Van Buiten, Ryan J Elias.
Int J Mol Sci, 2021 Jan 14; 22(2). PMID: 33435615    Free PMC article.
Review.
The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance.
Nastaran Asri, Mohammad Rostami-Nejad, Robert P Anderson, Kamran Rostami.
Appl Clin Genet, 2021 Feb 20; 14. PMID: 33603437    Free PMC article.
Review.
Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes.
Mara Cerqueiro Bybrant, Elin Udén, +16 authors, Annelie Carlsson.
Pediatr Diabetes, 2020 Dec 02; 22(3). PMID: 33259121    Free PMC article.
GLP-1 and Intestinal Diseases.
Jenna Elizabeth Hunt, Jens Juul Holst, Palle Bekker Jeppesen, Hannelouise Kissow.
Biomedicines, 2021 May 01; 9(4). PMID: 33916501    Free PMC article.
Review.
Effect of a gluten-free diet on albuminuria in children with newly diagnosed celiac disease.
Jeremiah Levine, Leora Hauptman, Libia Moy, Howard Trachtman.
Glomerular Dis, 2021 Aug 10; 1(1). PMID: 34368799    Free PMC article.