Journal Article
. 1991 Jul; 325(3):164-70.
doi: 10.1056/NEJM199107183250305.

Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer

J Crawford 1 H Ozer  R Stoller  D Johnson  G Lyman  I Tabbara  M Kris  J Grous  V Picozzi  G Rausch  
  • PMID: 1711156
  •     234 citations


Background: Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients with cancer. We conducted a randomized clinical trial to test this hypothesis and the clinical implications.

Methods: Patients with small-cell lung cancer were enrolled in a multicenter, randomized, double-blind, placebo-controlled trial of recombinant methionyl G-CSF to study the incidence of infection as manifested by fever with neutropenia (absolute neutrophil count, less than 1.0 x 10(9) per liter, with a temperature greater than or equal to 38.2 degrees C) resulting from up to six cycles of chemotherapy with cyclophosphamide, doxorubicin, and etoposide. The patients were randomly assigned to receive either placebo or G-CSF, with treatment beginning on day 4 and continuing through day 17 of a 21-day cycle.

Results: The safety of the study treatment could be evaluated in 207 of the 211 patients assigned to either drug, and its efficacy in 199. At least one episode of fever with neutropenia occurred in 77 percent of the placebo group, as compared with 40 percent of the G-CSF group (P less than 0.001). Over all cycles of chemotherapy, the median duration of grade IV neutropenia (absolute neutrophil count, less than 0.5 x 10(9) per liter) was six days with placebo as compared with one day with G-CSF. During cycles of blinded treatment, the number of days of treatment with intravenous antibiotics, the number of days of hospitalization, and the incidence of confirmed infections were reduced by approximately 50 percent when G-CSF was given, as compared with placebo. Mild-to-moderate medullary bone pain occurred in 20 percent of the patients receiving G-CSF.

Conclusions: The use of G-CSF as an adjunct to chemotherapy in patients with small-cell cancer of the lung was well tolerated and led to reductions in the incidence of fever with neutropenia and culture-confirmed infections; in the incidence, duration, and severity of grade IV neutropenia; and in the total number of days of treatment with intravenous antibiotics and days of hospitalization.

Granulocyte colony-stimulating factor treatment in AIDS patients.
U R Hengge, N H Brockmeyer, M Goos.
Clin Investig, 1992 Oct 01; 70(10). PMID: 1280496
The use of granulocyte colony-stimulating factor to shorten the interval between cycles of mitomycin C, vindesine, and cisplatin chemotherapy in non-small-cell lung cancer.
M Takada, M Fukuoka, +7 authors, T Kuriyama.
Cancer Chemother Pharmacol, 1992 Jan 01; 31(3). PMID: 1281446
Phase II feasibility study of high dose epirubicin plus etoposide and cisplatin (HDEEC) regimen in small cell lung cancer.
R Rosell, J Carles, +5 authors, N Haboubi.
Invest New Drugs, 1992 Jul 01; 10(2). PMID: 1323550
The impact of surgery on the multidisciplinary treatment of bronchogenic small cell carcinoma (updated review including ongoing studies).
W Theuer, O Selawry, K Karrer.
Med Oncol Tumor Pharmacother, 1992 Jan 01; 9(3). PMID: 1341324
New perspectives in lung cancer. 4. Haematopoietic growth factors and lung cancer treatment.
N Thatcher.
Thorax, 1992 Feb 01; 47(2). PMID: 1372450    Free PMC article.
Current issues in cancer. Biological therapy.
T Perren, P Selby.
BMJ, 1992 Jun 20; 304(6842). PMID: 1378335    Free PMC article.
G-CSF: status quo and new indications.
F Herrmann.
Infection, 1992 Jul 01; 20(4). PMID: 1381701
Immunomodulators. Future prospects.
B C Takx-Köhlen.
Pharm Weekbl Sci, 1992 Aug 21; 14(4A). PMID: 1437506
Selective decontamination in neutropenic patients.
E Kurrle, T Schmeiser, W Kern.
Epidemiol Infect, 1992 Dec 01; 109(3). PMID: 1468518    Free PMC article.
The concept of dose intensification in the treatment of neoplastic disease.
U B Wandl, N Niederle.
Infection, 1992 Jan 01; 20 Suppl 2. PMID: 1493934
Respiratory diseases.
D G James.
Postgrad Med J, 1992 Mar 01; 68(797). PMID: 1589373    Free PMC article.
Recombinant granulocyte colony-stimulating factor (rG-CSF). A review of its pharmacological properties and prospective role in neutropenic conditions.
L M Hollingshead, K L Goa.
Drugs, 1991 Aug 01; 42(2). PMID: 1717226
Pharmacodynamic analysis of hematologic profiles.
G L Rosner, P Müller.
J Pharmacokinet Biopharm, 1994 Dec 01; 22(6). PMID: 7473079
First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.
J R Kendra, F P Rugman, +4 authors, L Russell.
Postgrad Med J, 1993 Nov 01; 69(817). PMID: 7507240    Free PMC article.
The intramuscular administration of granulocyte colony-stimulating factor as an adjunct to chemotherapy in pretreated ovarian cancer patients: an Italian Trials in Medical Oncology (ITMO) Group pilot study.
A Di Leo, E Bajetta, +7 authors, F Raspagliesi.
Br J Cancer, 1994 May 01; 69(5). PMID: 7514030    Free PMC article.
Recombinant methionyl granulocyte colony-stimulating factor (filgrastim): a new dimension in immunotherapy.
G Schwab, T Hecht.
Ann Hematol, 1994 Jul 01; 69(1). PMID: 7520285
Erysipelas in neutropenia of unknown origin, successfully treated with r-metHuG-CSF (filgrastim)
M Müller-Lühr, N Breyer, A Martin, H Haacke.
Ann Hematol, 1994 Aug 01; 69(2). PMID: 7521672
Optimizing the effectiveness of hematopoietic growth factors.
D E Williams.
J Clin Immunol, 1994 Jul 01; 14(4). PMID: 7523435
Phase I study of mitozantrone, methotrexate and mitomycin with granulocyte colony-stimulating factor (filgrastim) in patients with advanced breast cancer.
M E O'Brien, M Nicolson, +3 authors, T J Powles.
Br J Cancer, 1994 Nov 01; 70(5). PMID: 7524607    Free PMC article.
Successful treatment of a Trichosporon beigelii septicemia in a granulocytopenic patient with amphotericin B and granulocyte colony-stimulating factor.
M E Grauer, C Bokemeyer, +2 authors, H Link.
Infection, 1994 Jul 01; 22(4). PMID: 7528173
Filgrastim. A review of its pharmacological properties and therapeutic efficacy in neutropenia.
J E Frampton, C R Lee, D Faulds.
Drugs, 1994 Nov 01; 48(5). PMID: 7530630
Colony-stimulating factors for adjunctive therapy of infections in neutropenic cancer patients.
J I Mayordomo, F Rivera, H Cortes-Funes.
Support Care Cancer, 1995 Jan 01; 3(1). PMID: 7535169
Risks of rhG-CSF treatment in drug-induced agranulocytosis.
H Demuynck, P Zachée, +4 authors, M A Boogaerts.
Ann Hematol, 1995 Mar 01; 70(3). PMID: 7536476
Optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation. A prospective randomized study.
A Torres Gómez, M A Jimenez, +7 authors, C Herrera.
Ann Hematol, 1995 Aug 01; 71(2). PMID: 7544628
Attempted dose intensified cyclophosphamide, etoposide, and granulocyte colony-stimulating factor for treatment of malignant astrocytoma.
H B Newton, C L Newton.
J Neurooncol, 1995 Jan 01; 24(3). PMID: 7595759
Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL).
R Scherrer, K Geissler, +7 authors, C Sillaber.
Ann Hematol, 1993 Jun 01; 66(6). PMID: 7686404
Use and toxicity of the colony-stimulating factors.
J R Schriber, R S Negrin.
Drug Saf, 1993 Jun 01; 8(6). PMID: 7687134
Effects of interleukin-3 on myelosuppression induced by chemotherapy for ovarian cancer and small cell undifferentiated tumours.
M W Dercksen, K Hoekman, +5 authors, H M Pinedo.
Br J Cancer, 1993 Nov 01; 68(5). PMID: 7692922    Free PMC article.
Systemic lupus erythematosus--disease management.
M F Gourley.
Springer Semin Immunopathol, 1994 Jan 01; 16(2-3). PMID: 7716709
Idiosyncratic drug-induced haematological abnormalities. Incidence, pathogenesis, management and avoidance.
W N Patton, S B Duffull.
Drug Saf, 1994 Dec 01; 11(6). PMID: 7727054
Common emergencies in cancer medicine: infectious and treatment-related syndromes, Part I.
C R Thomas, L V Wood, +3 authors, R Panicker.
J Natl Med Assoc, 1994 Oct 01; 86(10). PMID: 7807561    Free PMC article.
Present status and potential role of high-dose adjuvant chemotherapy in breast cancer with poor prognosis.
B Thürlimann.
Arch Gynecol Obstet, 1994 Jan 01; 255 Suppl 2. PMID: 7847932
Empirical therapy for bacterial infections in neutropenic patients.
J Klastersky.
Support Care Cancer, 1994 Nov 01; 2(6). PMID: 7858926
Interventional antimicrobial therapy in febrile neutropenic patients. Study Group of the Paul Ehrlich Society for Chemotherapy.
H Link, G Maschmeyer, +4 authors, D Adam.
Ann Hematol, 1994 Nov 01; 69(5). PMID: 7948312
Economic study of neutropenia induced by myelotoxic chemotherapy.
M C Montero, M L Valdivia, +4 authors, M Atienza.
Pharm World Sci, 1994 Aug 05; 16(4). PMID: 7951132
From laboratory expertise to clinical practice: multidrug-resistance-based gene therapy becomes available for urologists.
G H Mickisch, F H Schroeder.
World J Urol, 1994 Jan 01; 12(2). PMID: 8087140
Cytokines in Hematology, Oncology, and Immunology. 3rd International Symposium. Hannover, June 23-26, 1993. Abstracts.
Ann Hematol, 1993 Jun 01; 66(6). PMID: 8100451    Free PMC article.
The aged patient with lung cancer. Management recommendations.
V Zagonel, U Tirelli, +6 authors, S Monfardini.
Drugs Aging, 1994 Jan 01; 4(1). PMID: 8130381
Febrile neutropenia.
J Klastersky.
Support Care Cancer, 1993 Sep 01; 1(5). PMID: 8156232
Efficacy of recombinant human granulocyte-macrophage colony-stimulating factor for chemotherapy-induced leukopenia in patients with non-small-cell lung cancer.
K Eguchi, J Kabe, +7 authors, T Uzawa.
Cancer Chemother Pharmacol, 1994 Jan 01; 34(1). PMID: 8174201
Granulocyte-macrophage colony-stimulating factor (GM-CSF) allows acceleration and dose intensity increase of CEF chemotherapy: a randomised study in patients with advanced breast cancer.
A Ardizzoni, M Venturini, +7 authors, P Queirolo.
Br J Cancer, 1994 Feb 01; 69(2). PMID: 8297739    Free PMC article.
Bone marrow myeloid cell kinetics during treatment of small cell carcinoma of the lung with chemotherapy not associated and associated with granulocyte-macrophage colony-stimulating factor.
A Riccardi, M Danova, +7 authors, L Chieco-Bianchi.
Ann Hematol, 1993 Apr 01; 66(4). PMID: 8387346
Adverse haematological complications of anticancer drugs. Clinical presentation, management and avoidance.
D C Bodensteiner, G C Doolittle.
Drug Saf, 1993 Mar 01; 8(3). PMID: 8452662
Early tracheotomy in neutropenic, mechanically ventilated patients: rationale and results of a pilot study.
F Blot, M Guiguet, +3 authors, B Escudier.
Support Care Cancer, 1995 Sep 01; 3(5). PMID: 8520874
Safety of tracheotomy in neutropenic patients: a retrospective study of 26 consecutive cases.
F Blot, G Nitenberg, +5 authors, B Escudier.
Intensive Care Med, 1995 Aug 01; 21(8). PMID: 8522676    Free PMC article.
Physiological aspects of aging. Implications for the treatment of cancer.
S M Lichtman.
Drugs Aging, 1995 Sep 01; 7(3). PMID: 8535051
Antifungal combination therapy with granulocyte colony-stimulating factor and fluconazole in experimental disseminated candidiasis.
J R Graybill, R Bocanegra, M Luther.
Eur J Clin Microbiol Infect Dis, 1995 Aug 01; 14(8). PMID: 8565989
Critical influence of timing of administration of granulocyte colony-stimulating factor on antibacterial effect in experimental endocarditis due to Pseudomonas aeruginosa.
S Vignes, B Fantin, +3 authors, C Carbon.
Antimicrob Agents Chemother, 1995 Dec 01; 39(12). PMID: 8593006    Free PMC article.
A feasibility study of accelerated polychemotherapy with cisplatin, epidoxorubicin and cyclophosphamide (PEC) in advanced ovarian cancer.
P Pronzato, G Bertelli, A Vigani, F Vaira.
Br J Cancer, 1996 Jun 01; 73(11). PMID: 8645591    Free PMC article.
Aging and haemopoiesis. Implications for treatment with haemopoietic growth factors.
G S Chatta, D C Dale.
Drugs Aging, 1996 Jul 01; 9(1). PMID: 8818584
Phase I study of simultaneous dose escalation and schedule acceleration of cyclophosphamide-doxorubicin-etoposide using granulocyte colony-stimulating factor with or without antimicrobial prophylaxis in patients with small-cell lung cancer.
A Ardizzoni, M C Pennucci, +7 authors, R Rosso.
Br J Cancer, 1996 Oct 01; 74(7). PMID: 8855989    Free PMC article.
CODE chemotherapy with and without granulocyte colony-stimulating factor in small-cell lung cancer.
M Fukuoka, N Masuda, +10 authors, K Furuse.
Br J Cancer, 1997 Jan 01; 75(2). PMID: 9010043    Free PMC article.
Hematopoietic growth factors in cancer patients with invasive fungal infections.
F Offner.
Eur J Clin Microbiol Infect Dis, 1997 Jan 01; 16(1). PMID: 9063675
[G-CSF in radiochemotherapy].
M Riepl, R Fietkau, R Sauer.
Strahlenther Onkol, 1997 Feb 01; 173(2). PMID: 9072843
Tolerability and efficacy of GM-CSF [Leucomax] in patients with small cell lung cancer treated with intensive chemotherapy.
J Walewski, J Romejko-Jarosińska, +2 authors, P Siedlecki.
Med Oncol, 1996 Dec 01; 13(4). PMID: 9152970
Haemopoietic growth factors.
N J Ketley, A C Newland.
Postgrad Med J, 1997 Apr 01; 73(858). PMID: 9156123    Free PMC article.
Granulocyte colony-stimulating factor receptor expression on human transitional cell carcinoma of the bladder.
M Tachibana, A Miyakawa, +5 authors, J I Hata.
Br J Cancer, 1997 Jan 01; 75(10). PMID: 9166942    Free PMC article.
A comparative review of colony-stimulating factors.
J Nemunaitis.
Drugs, 1997 Nov 14; 54(5). PMID: 9360058
Timing of recombinant human granulocyte colony-stimulating factor administration on neutropenia induced by cyclophosphamide in normal mice.
M Misaki, Y Ueyama, G Tsukamoto, T Matsumura.
Br J Cancer, 1998 Apr 07; 77(6). PMID: 9528829    Free PMC article.
The discovery, development and clinical applications of granulocyte colony-stimulating factor.
D C Dale.
Trans Am Clin Climatol Assoc, 1998 May 28; 109. PMID: 9601125    Free PMC article.
Economic and quality-of-life aspects of treating small cell lung cancer.
P Graham, J Boyages.
Pharmacoeconomics, 1993 May 08; 3(6). PMID: 10146879
Recombinant granulocyte colony-stimulating factor (rG-CSF): pharmacoeconomic considerations in chemotherapy-induced neutropenia.
D Faulds, N J Lewis, R J Milne.
Pharmacoeconomics, 1992 Mar 09; 1(4). PMID: 10147015
The costs of treating febrile neutropenia in patients with malignant blood disorders.
B Leese, R Collin, D J Clark.
Pharmacoeconomics, 1994 Aug 06; 6(3). PMID: 10155266
Methodological issues in economic assessments of new therapies. The case of colony-stimulating factors.
M Drummond, J Menzin, G Oster.
Pharmacoeconomics, 1993 Dec 09; 6 Suppl 2. PMID: 10155592
Pharmacoeconomic evaluation of lenograstim. Conclusions and future directions.
J Menzin, G Oster, V Cour-Chabernaud, D Richard.
Pharmacoeconomics, 1993 Dec 09; 6 Suppl 2. PMID: 10155595
Pharmacoeconomic aspects in the treatment of curable and incurable cancer.
V Jønsson, S R Clausen, M M Hansen.
Pharmacoeconomics, 1995 Sep 05; 8(4). PMID: 10155669
Filgrastim. A reappraisal of pharmacoeconomic considerations in the prophylaxis and treatment of chemotherapy-induced neutropenia.
J E Frampton, D Faulds.
Pharmacoeconomics, 1995 Dec 09; 9(1). PMID: 10161371
Treatment costs and quality of life with granulocyte-macrophage colony-stimulating factor in patients with antineoplastic therapy-related febrile neutropenia. Results of a randomised placebo-controlled trial.
C A Uyl-de Groot, E Vellenga, +3 authors, F F Rutten.
Pharmacoeconomics, 1997 Aug 05; 12(3). PMID: 10170460
Cost-benefit analysis of prophylactic granulocyte colony-stimulating factor during CHOP antineoplastic therapy for non-Hodgkin's lymphoma.
G Dranitsaris, C Altmayer, I Quirt.
Pharmacoeconomics, 1997 May 07; 11(6). PMID: 10173030
Peripheral blood progenitor cell cycle kinetics following priming with pIXY321 in patients treated with the "ICE" regimen.
J R Murren, A Gollerkeri, +5 authors, B Smith.
Yale J Biol Med, 1999 Oct 20; 71(5). PMID: 10527363    Free PMC article.
Impact of ASCO guidelines for the use of hematopoietic colony stimulating factors (CSFs): survey results of fifteen Paris university hospitals.
I Debrix, I Madelaine, +7 authors, P Tilleul.
Pharm World Sci, 2000 Feb 05; 21(6). PMID: 10658236
Feasibility of a dose-intensive CMF regimen with granulocyte colony-stimulating factor as adjuvant therapy in premenopausal patients with node-positive breast cancer.
A M Bos, H de Graaf, +2 authors, P H Willemse.
Br J Cancer, 2000 Jun 23; 82(12). PMID: 10864198    Free PMC article.
Haemopoietic growth factors in paediatric oncology: a review of the literature.
L M Wagner, W L Furman.
Paediatr Drugs, 2001 Apr 20; 3(3). PMID: 11310717
Postdischarge adverse drug reactions in primary care originating from hospital care in France: a nationwide prospective study.
L Letrilliart, T Hanslik, +3 authors, A Flahault.
Drug Saf, 2001 Oct 26; 24(10). PMID: 11676305
Macrophage colony-stimulating factor prevents febrile neutropenia induced by chemotherapy.
T Hidaka, M Fujimura, M Sakai, S Saito.
Jpn J Cancer Res, 2001 Nov 21; 92(11). PMID: 11714451    Free PMC article.
A three-arm phase III randomised trial assessing, in patients with extensive-disease small-cell lung cancer, accelerated chemotherapy with support of haematological growth factor or oral antibiotics.
J P Sculier, M Paesmans, +13 authors, European Lung Cancer Working Party.
Br J Cancer, 2001 Nov 27; 85(10). PMID: 11720426    Free PMC article.
Failing to live up to the fanfare? A personal perspective on obstacles to the clinical development of thrombopoietic agents.
R L Basser, C G Begley.
Int J Hematol, 2002 Jan 17; 74(4). PMID: 11794693
Colony-stimulating factors for the management of neutropenia in cancer patients.
David C Dale.
Drugs, 2002 Dec 14; 62 Suppl 1. PMID: 12479591
Filgrastim in patients with neutropenia: potential effects on quality of life.
Gary H Lyman, Nicole M Kuderer.
Drugs, 2002 Dec 14; 62 Suppl 1. PMID: 12479595
Pegfilgrastim administered once per cycle reduces incidence of chemotherapy-induced neutropenia.
Jeffrey Crawford.
Drugs, 2002 Dec 14; 62 Suppl 1. PMID: 12479597
Phase 1 dose escalation study of docetaxel with filgrastim support in patients with advanced solid tumors.
Gregory A Masters, Bruce E Brockstein, Sridhar Mani, Mark J Ratain.
Med Oncol, 2003 Apr 01; 20(1). PMID: 12665678
Mechanistic models for myelosuppression.
Lena E Friberg, Mats O Karlsson.
Invest New Drugs, 2003 Aug 02; 21(2). PMID: 12889739
First-cycle absolute neutrophil count can be used to improve chemotherapy-dose delivery and reduce the risk of febrile neutropenia in patients receiving adjuvant therapy: a validation study.
Edgardo Rivera, M Haim Erder, +2 authors, Gabriel N Hortobagyi.
Breast Cancer Res, 2003 Aug 21; 5(5). PMID: 12927041    Free PMC article.
The impact of frequent injections for hematopoietic growth factor support on patients receiving chemotherapy: an observational study.
Susan Haithcox, Carmella R Ramnes, +2 authors, Gary H Lyman.
BMC Nurs, 2003 Sep 23; 2(1). PMID: 14498996    Free PMC article.
The role of colony-stimulating factors and granulocyte transfusion in treatment options for neutropenia in children with cancer.
Der-Cherng Liang.
Paediatr Drugs, 2003 Sep 27; 5(10). PMID: 14510625
Impact of neutropenia on delivering planned adjuvant chemotherapy: UK audit of primary breast cancer patients.
R C F Leonard, D Miles, +2 authors, UK Breast Cancer Neutropenia Audit Group.
Br J Cancer, 2003 Dec 04; 89(11). PMID: 14647139    Free PMC article.
Metronomic therapy for breast cancer.
Hanspreet Kaur, G Thomas Budd.
Curr Oncol Rep, 2003 Dec 11; 6(1). PMID: 14664761
Economic evaluations of granulocyte colony-stimulating factor: in the prevention and treatment of chemotherapy-induced neutropenia.
Marc Esser, Helmut Brunner.
Pharmacoeconomics, 2004 Jan 31; 21(18). PMID: 14750898
Systematic Review.
A prospective randomised evaluation of G-CSF or G-CSF plus oral antibiotics in chemotherapy-treated patients at high risk of developing febrile neutropenia.
Y Lalami, M Paesmans, +5 authors, J Klastersky.
Support Care Cancer, 2004 Jul 06; 12(10). PMID: 15235901
Extensive necrotising fasciitis caused by Pseudomonas aeruginosa in a child with acute myeloid leukaemia: case report and literature review.
Wen-Tsung Lo, Shin-Nan Cheng, Chih-Chien Wang, Mong-Ling Chu.
Eur J Pediatr, 2004 Oct 19; 164(2). PMID: 15490233
Continuing clozapine treatment despite neutropenia.
David Esposito, Frédéric Rouillon, Frédéric Limosin.
Eur J Clin Pharmacol, 2005 Jan 22; 60(11). PMID: 15660271
Neoplastic fever: a neglected paraneoplastic syndrome.
Jason A Zell, Jae C Chang.
Support Care Cancer, 2005 May 03; 13(11). PMID: 15864658
Experiencing neutropenia: quality of life interviews with adult cancer patients.
Barry V Fortner, Kurt W Tauer, +2 authors, Lee S Schwartzberg.
BMC Nurs, 2005 Jul 12; 4. PMID: 16004611    Free PMC article.
Granulocyte colony--stimulating factor for chemotherapy-induced neutropenia in patients with small cell lung cancer : the 40% rule revisited.
Elizabeth A Calhoun, Glen T Schumock, +6 authors, Charles L Bennett.
Pharmacoeconomics, 2005 Aug 16; 23(8). PMID: 16097839
The safety of full-dose chemotherapy with secondary prophylactic granulocyte colony stimulating factor (G-CSF) following a prior cycle with febrile neutropenia.
Nissim Haim, Katerina Shulman, Hadassah Goldberg, Medy Tsalic.
Med Oncol, 2005 Aug 20; 22(3). PMID: 16110133
Temporal and geographic variation in the use of hematopoietic growth factors in older women receiving breast cancer chemotherapy: findings from a large population-based cohort.
Xianglin L Du, David R Lairson, Charles E Begley, Shenying Fang.
J Clin Oncol, 2005 Nov 30; 23(34). PMID: 16314624    Free PMC article.
Green fluorescent protein labeling Escherichia coli TG1 confirms intestinal bacterial translocation in a rat model of chemotherapy.
Desheng Song, Bin Shi, +5 authors, Jieshou Li.
Curr Microbiol, 2006 Jan 05; 52(1). PMID: 16392000
Low-dose granulocyte colony-stimulating factor overcomes neutropenia in the treatment of non-Hodgkin's lymphoma with higher cost-effectiveness.
Takeshi Hara, Hisashi Tsurumi, +10 authors, Hisataka Moriwaki.
Int J Hematol, 2006 Mar 15; 82(5). PMID: 16533747
Neutropenic event risk and impaired chemotherapy delivery in six European audits of breast cancer treatment.
Matthias Schwenkglenks, Christian Jackisch, +7 authors, Robert Leonard.
Support Care Cancer, 2006 Apr 20; 14(9). PMID: 16622653
Confirmation and prevention of intestinal barrier dysfunction and bacterial translocation caused by methotrexate.
Desheng Song, Bin Shi, +6 authors, Jieshou Li.
Dig Dis Sci, 2006 Aug 24; 51(9). PMID: 16927144
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators.
Anja K Schröder, Maren von der Ohe, +8 authors, Lothar Rink.
Immunology, 2006 Oct 28; 119(3). PMID: 17067311    Free PMC article.
Colony-stimulating factors: clinical evidence for treatment and prophylaxis of chemotherapy-induced febrile neutropenia.
César Gómez Raposo, Alvaro Pinto Marín, Manuel González Barón.
Clin Transl Oncol, 2006 Nov 01; 8(10). PMID: 17074671
Achieving full-dose, on-schedule administration of ACE chemotherapy every 14 days for the treatment of patients with extensive small-cell lung cancer.
R Pirker, E Ulsperger, +5 authors, T Skacel.
Lung, 2007 Jan 20; 184(5). PMID: 17235728
Therapeutic use of granulocyte colony-stimulating factors for established febrile neutropenia: effect on costs from a hospital perspective.
Leon E Cosler, Adi Eldar-Lissai, +4 authors, Gary H Lyman.
Pharmacoeconomics, 2007 Apr 04; 25(4). PMID: 17402806
Modern management of small-cell lung cancer.
Roberta Ferraldeschi, Sofia Baka, +3 authors, Paul Lorigan.
Drugs, 2007 Oct 12; 67(15). PMID: 17927281
Canadian supportive care recommendations for the management of neutropenia in patients with cancer.
C T Kouroukis, S Chia, +4 authors, J Mikhael.
Curr Oncol, 2008 Mar 05; 15(1). PMID: 18317581    Free PMC article.
Neutropenia occurrence and predictors of reduced chemotherapy delivery: results from the INC-EU prospective observational European neutropenia study.
Ruth Pettengell, Matthias Schwenkglenks, +6 authors, Impact of Neutropenia in Chemotherapy-European Study Group (INC-EU).
Support Care Cancer, 2008 Mar 21; 16(11). PMID: 18351398
XM02 is superior to placebo and equivalent to Neupogen in reducing the duration of severe neutropenia and the incidence of febrile neutropenia in cycle 1 in breast cancer patients receiving docetaxel/doxorubicin chemotherapy.
A del Giglio, A Eniu, +2 authors, H Lubenau.
BMC Cancer, 2008 Nov 19; 8. PMID: 19014494    Free PMC article.
Pegfilgrastim and daily granulocyte colony-stimulating factor: patterns of use and neutropenia-related outcomes in cancer patients in Spain--results of the LEARN Study.
D Almenar, J Mayans, +8 authors, J Sanchez.
Eur J Cancer Care (Engl), 2008 Dec 17; 18(3). PMID: 19076208    Free PMC article.
Neutrophil biology and the next generation of myeloid growth factors.
David C Dale.
J Natl Compr Canc Netw, 2009 Jan 30; 7(1). PMID: 19176209    Free PMC article.
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models.
Farbod Shojaei, Xiumin Wu, +5 authors, Napoleone Ferrara.
Proc Natl Acad Sci U S A, 2009 Apr 07; 106(16). PMID: 19346489    Free PMC article.
Highly Cited.
Effects of recombinant human granulocyte colony-stimulating factor (filgrastim) on ECG parameters in neutropenic patients: a single-centre, prospective study.
Ozlem Guneysel, Ozge Ecmel Onur, Arzu Denizbasi.
Clin Drug Investig, 2009 Jul 14; 29(8). PMID: 19591516
Prevention of febrile neutropenia: use of granulocyte colony-stimulating factors.
S Kelly, D Wheatley.
Br J Cancer, 2009 Sep 17; 101 Suppl 1. PMID: 19756005    Free PMC article.
Phase II, randomized, open-label study of pegfilgrastim-supported VDC/IE chemotherapy in pediatric sarcoma patients.
Sheri L Spunt, Helen Irving, +5 authors, Victor M Santana.
J Clin Oncol, 2010 Feb 10; 28(8). PMID: 20142595    Free PMC article.
Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer.
Andrea L Merz, Natalie J Serkova.
Biomark Med, 2010 Feb 18; 3(3). PMID: 20160999    Free PMC article.
Development and validation of a prediction model for the risk of developing febrile neutropenia in the first cycle of chemotherapy among elderly patients with breast, lung, colorectal, and prostate cancer.
Wylie Hosmer, Jennifer Malin, Mitchell Wong.
Support Care Cancer, 2010 Feb 25; 19(3). PMID: 20179995    Free PMC article.
Prophylaxis of chemotherapy-induced febrile neutropenia with granulocyte colony-stimulating factors: where are we now?
Matti Aapro, Jeffrey Crawford, Didier Kamioner.
Support Care Cancer, 2010 Mar 02; 18(5). PMID: 20191292    Free PMC article.
The colony-stimulating factors and cancer.
Donald Metcalf.
Nat Rev Cancer, 2010 May 25; 10(6). PMID: 20495576    Free PMC article.
Pegfilgrastim on the Same Day Versus Next Day of Chemotherapy in Patients With Breast Cancer, Non-Small-Cell Lung Cancer, Ovarian Cancer, and Non-Hodgkin's Lymphoma: Results of Four Multicenter, Double-Blind, Randomized Phase II Studies.
Howard A Burris, Chandra P Belani, +6 authors, Alan Saven.
J Oncol Pract, 2010 Sep 03; 6(3). PMID: 20808556    Free PMC article.
How we treat febrile neutropenia in patients receiving cancer chemotherapy.
Gary H Lyman, Kenneth V I Rolston.
J Oncol Pract, 2010 Sep 03; 6(3). PMID: 20808559    Free PMC article.
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.
Marcin Kowanetz, Xiumin Wu, +18 authors, Napoleone Ferrara.
Proc Natl Acad Sci U S A, 2010 Nov 18; 107(50). PMID: 21081700    Free PMC article.
Highly Cited.
Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy.
Gary H Lyman, Nicole M Kuderer, +4 authors, David C Dale.
Cancer, 2011 Apr 22; 117(9). PMID: 21509769    Free PMC article.
Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae.
An-Bin Zhao, Bin Yu, +4 authors, Xiao-Yin Chen.
Pharmacogn Mag, 2011 Jul 01; 7(26). PMID: 21716623    Free PMC article.
Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis.
Katy L Cooper, Jason Madan, +2 authors, Ron L Akehurst.
BMC Cancer, 2011 Sep 29; 11. PMID: 21943360    Free PMC article.
Systematic Review.
Re: personalized medicine and cancer supportive care: appropriate use of colony-stimulating factor support of chemotherapy.
Arnold L Potosky, Jennifer L Malin, +2 authors, Jane C Weeks.
J Natl Cancer Inst, 2011 Nov 01; 103(24). PMID: 22036767    Free PMC article.
Aurora kinase inhibitors: progress towards the clinic.
Madhu Kollareddy, Daniella Zheleva, +3 authors, Marian Hajduch.
Invest New Drugs, 2012 Feb 22; 30(6). PMID: 22350019    Free PMC article.
Highly Cited. Review.
A way forward on the medically appropriate use of white cell growth factors.
Thomas J Smith, Bruce E Hillner.
J Clin Oncol, 2012 Mar 01; 30(14). PMID: 22370327    Free PMC article.
Pharmacoeconomics of the myeloid growth factors: a critical and systematic review.
Bradford R Hirsch, Gary H Lyman.
Pharmacoeconomics, 2012 May 01; 30(6). PMID: 22540394
Systematic Review.
Treatment-related death in patients with small-cell lung cancer in phase III trials over the last two decades.
Nobuaki Ochi, Katsuyuki Hotta, +7 authors, Katsuyuki Kiura.
PLoS One, 2012 Aug 11; 7(8). PMID: 22880112    Free PMC article.
Guideline-Based Peer-to-Peer Consultation Optimizes Pegfilgrastim Use With No Adverse Clinical Consequences.
Marc L Fishman, Akhil Kumar, +2 authors, William J M Hrushesky.
J Oncol Pract, 2012 Sep 04; 8(3 Suppl). PMID: 22942828    Free PMC article.
Filgrastim improves survival in lethally irradiated nonhuman primates.
Ann M Farese, Melanie V Cohen, +4 authors, Thomas J MacVittie.
Radiat Res, 2012 Dec 06; 179(1). PMID: 23210705    Free PMC article.
Small cell lung cancer.
Gregory P Kalemkerian, Wallace Akerley, +24 authors, National Comprehensive Cancer Network.
J Natl Compr Canc Netw, 2013 Jan 12; 11(1). PMID: 23307984    Free PMC article.
Highly Cited.
Supportive therapy in medical therapy of head and neck tumors.
Hartmut Link.
GMS Curr Top Otorhinolaryngol Head Neck Surg, 2013 Jan 16; 11. PMID: 23320053    Free PMC article.
Neutropenia and G-CSF in lymphoproliferative diseases.
Roberto Ria, Antonia Reale, +2 authors, Angelo Vacca.
Hematology, 2013 Jan 17; 18(3). PMID: 23321273    Free PMC article.
Effectiveness of daily versus non-daily granulocyte colony-stimulating factors in patients with solid tumours undergoing chemotherapy: a multivariate analysis of data from current practice.
D Almenar Cubells, C Bosch Roig, +8 authors, LEARN II Study Group.
Eur J Cancer Care (Engl), 2013 Jan 22; 22(3). PMID: 23331323    Free PMC article.
Colony-stimulating factors for febrile neutropenia during cancer therapy.
Charles L Bennett, Benjamin Djulbegovic, LeAnn B Norris, James O Armitage.
N Engl J Med, 2013 Mar 22; 368(12). PMID: 23514290    Free PMC article.
Real-world impact of granulocyte-colony stimulating factor on febrile neutropenia.
A K Altwairgi, W M Hopman, M Mates.
Curr Oncol, 2013 Jun 06; 20(3). PMID: 23737687    Free PMC article.
Efficacy and safety of lipegfilgrastim versus pegfilgrastim: a randomized, multicenter, active-control phase 3 trial in patients with breast cancer receiving doxorubicin/docetaxel chemotherapy.
Igor Bondarenko, Oleg A Gladkov, +2 authors, Peter Bias.
BMC Cancer, 2013 Aug 16; 13. PMID: 23945072    Free PMC article.
Epidemiology of chemotherapy-induced neutropenia at a tertiary university hospital in Oman.
Maram Abou Saleh, Rose Ngozi Mafiana, +3 authors, Ibrahim Al-Zakwani.
Int J Clin Pharm, 2013 Oct 09; 35(6). PMID: 24101032
Neutropenia management and granulocyte colony-stimulating factor use in patients with solid tumours receiving myelotoxic chemotherapy--findings from clinical practice.
K Krzemieniecki, P Sevelda, +7 authors, J Maenpaa.
Support Care Cancer, 2013 Oct 25; 22(3). PMID: 24154740    Free PMC article.
Study design: two long-term observational studies of the biosimilar filgrastim Nivestim™ (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia.
Didier Kamioner, Stefan Fruehauf, +3 authors, Christian Berthou.
BMC Cancer, 2013 Nov 19; 13. PMID: 24237790    Free PMC article.
Efficacy and safety analysis of once per cycle pegfilgrastim and daily lenograstim in patients with breast cancer receiving adjuvant myelosuppressive chemotherapy FEC 100: a pilot study.
Luigi Rossi, Federica Tomao, +10 authors, Silverio Tomao.
Ther Clin Risk Manag, 2013 Nov 21; 9. PMID: 24255599    Free PMC article.
Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.
Hui Lin Chua, P Artur Plett, +5 authors, Christie M Orschell.
Health Phys, 2013 Nov 28; 106(1). PMID: 24276547    Free PMC article.
A prospective observational study to evaluate G-CSF usage in patients with solid tumors receiving myelosuppressive chemotherapy in Italian clinical oncology practice.
S Barni, V Lorusso, +10 authors, P Pronzato.
Med Oncol, 2013 Dec 07; 31(1). PMID: 24307348
Clinical efficacy of adjunctive G-CSF on solid tumor and lymphoma patients with established febrile neutropenia.
Alexandre Chan, Qi Xuan Wong, +2 authors, Li Yang Hsu.
Support Care Cancer, 2013 Dec 10; 22(4). PMID: 24317848
Impact of granulocyte colony-stimulating factors in metastatic colorectal cancer patients.
A Amadio, R Burkes, +2 authors, B Coleman.
Curr Oncol, 2014 Feb 14; 21(1). PMID: 24523621    Free PMC article.
Severe neutropenia and relative dose intensity among patients<65 and ≥65 years with non-Hodgkin's lymphoma receiving CHOP-based chemotherapy.
Lee S Schwartzberg, Mansoor Saleh, Sadie Whittaker, Esteban Abella.
Support Care Cancer, 2014 Feb 19; 22(7). PMID: 24535242
Use of pegfilgrastim primary prophylaxis and risk of infection, by chemotherapy cycle and regimen, among patients with breast cancer or non-Hodgkin's lymphoma.
Wendy J Langeberg, Conchitina C Siozon, +2 authors, Victoria M Chia.
Support Care Cancer, 2014 Mar 22; 22(8). PMID: 24652049
Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study.
Eva Culakova, Ramya Thota, +5 authors, Gary H Lyman.
Cancer Med, 2014 Apr 08; 3(2). PMID: 24706592    Free PMC article.
Risk and consequences of chemotherapy-induced neutropenic complications in patients receiving daily filgrastim: the importance of duration of prophylaxis.
Derek Weycker, Rich Barron, +3 authors, Andrew G Glass.
BMC Health Serv Res, 2014 Apr 29; 14. PMID: 24767095    Free PMC article.
Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony-stimulating factor--a potential neoplastic marker: a case report and review of the literature.
Anup Kasi Loknath Kumar, Megha Teeka Satyan, +2 authors, Peter Van Veldhuizen.
J Med Case Rep, 2014 Jun 03; 8. PMID: 24885603    Free PMC article.
Septic shock due to community-acquired Pseudomonas aeruginosa necrotizing fasciitis: A case report and literature review.
Guang-Ju Zhao, Guang-Liang Hong, +2 authors, Zhong-Qiu Lu.
Exp Ther Med, 2014 Jun 14; 7(6). PMID: 24926341    Free PMC article.
Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial.
Benjamin Hibbert, Bradley Hayley, +13 authors, Christopher Glover.
CMAJ, 2014 Jun 18; 186(11). PMID: 24934893    Free PMC article.
Necrotizing fasciitis in a young patient with acute myeloid leukemia - a diagnostic challenge.
Mareen Brumann, Viktoria Bogner, +3 authors, Wolf Mutschler.
Patient Saf Surg, 2014 Jul 09; 8. PMID: 25002906    Free PMC article.
Understanding, treating and avoiding hematological disease: better medicine through mathematics?
David C Dale, Michael C Mackey.
Bull Math Biol, 2014 Sep 13; 77(5). PMID: 25213154    Free PMC article.
Granulocyte colony-stimulating factors as prophylaxis against febrile neutropenia.
Sol Cortés de Miguel, Miguel Ángel Calleja-Hernández, Salomón Menjón-Beltrán, Inmaculada Vallejo-Rodríguez.
Support Care Cancer, 2014 Oct 07; 23(2). PMID: 25284722
Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia.
Laurence A Boxer, Audrey Anna Bolyard, +5 authors, David C Dale.
Obstet Gynecol, 2015 Jan 07; 125(1). PMID: 25560125    Free PMC article.
An open-label, randomized, multicenter dose-finding study of once-per-cycle pegfilgrastim versus daily filgrastim in Chinese breast cancer patients receiving TAC chemotherapy.
Wei Zhang, Zhiwei Jiang, +2 authors, Jielai Xia.
Med Oncol, 2015 Mar 31; 32(5). PMID: 25820754
The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials.
Li Wang, Onur Baser, +2 authors, Richard Barron.
Support Care Cancer, 2015 Mar 31; 23(11). PMID: 25821144    Free PMC article.
Systematic Review.
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
Ruth J Napier, Brian A Norris, +14 authors, Daniel Kalman.
PLoS Pathog, 2015 Mar 31; 11(3). PMID: 25822986    Free PMC article.
Phase II dose-finding study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy.
Oleg Gladkov, Vladimir Moiseyenko, +5 authors, Noa Avisar.
Med Oncol, 2015 May 15; 32(6). PMID: 25966791
Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor.
Tara Arvedson, James O'Kelly, Bing-Bing Yang.
BioDrugs, 2015 May 23; 29(3). PMID: 25998211    Free PMC article.
A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects.
Liat Adar, Noa Avisar, +2 authors, Ofer Spiegelstein.
Drug Des Devel Ther, 2015 Jun 02; 9. PMID: 26028962    Free PMC article.
Risk factors for bone pain among patients with cancer receiving myelosuppressive chemotherapy and pegfilgrastim.
H Xu, Q Gong, +2 authors, J H Page.
Support Care Cancer, 2015 Jul 15; 24(2). PMID: 26162536
Immunotherapy treatments for small-cell lung cancer: past, present and future.
Matthew Whitehurst, Alberto Chiappori.
Lung Cancer Manag, 2013 Jan 01; 2(6). PMID: 26236401    Free PMC article.
G-CSF and GM-CSF in Neutropenia.
Hrishikesh M Mehta, Michael Malandra, Seth J Corey.
J Immunol, 2015 Aug 09; 195(4). PMID: 26254266    Free PMC article.
Attitudes of physicians toward assessing risk and using granulocyte colony-stimulating factor as primary prophylaxis in patients receiving chemotherapy associated with an intermediate risk of febrile neutropenia.
Gilles Freyer, Ewa Kalinka-Warzocha, +9 authors, Zsolt Szabo.
Med Oncol, 2015 Sep 01; 32(10). PMID: 26315712
Investigation of the biological and anti-cancer properties of ellagic acid-encapsulated nano-sized metalla-cages.
Abhishek Dubey, Dae Won Park, +5 authors, Ki-Whan Chi.
Int J Nanomedicine, 2015 Sep 15; 10 Spec Iss. PMID: 26366074    Free PMC article.
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.
YanHe Lue, Ronald Swerdloff, +9 authors, Christina Wang.
Endocrinology, 2015 Sep 19; 156(12). PMID: 26384090    Free PMC article.
Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter?
Derek Weycker, Xiaoyan Li, +3 authors, May Hagiwara.
Support Care Cancer, 2015 Nov 27; 24(5). PMID: 26607482    Free PMC article.
Clinical safety of tbo-filgrastim, a short-acting human granulocyte colony-stimulating factor.
Ruth Pettengell, Peter Bias, Udo Mueller, Nicole Lang.
Support Care Cancer, 2016 Jan 19; 24(6). PMID: 26780505
Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients.
Roberto Guariglia, Maria Carmen Martorelli, +3 authors, Pellegrino Musto.
Biologics, 2016 Feb 10; 10. PMID: 26858523    Free PMC article.
Trajectory of absolute neutrophil counts in patients treated with pegfilgrastim on the day of chemotherapy versus the day after chemotherapy.
Yanli Li, Zandra Klippel, +3 authors, John H Page.
Cancer Chemother Pharmacol, 2016 Feb 18; 77(4). PMID: 26886017    Free PMC article.
Biosimilars in the management of neutropenia: focus on filgrastim.
Désirée Caselli, Simone Cesaro, Maurizio Aricò.
Biologics, 2016 Mar 05; 10. PMID: 26937170    Free PMC article.
An update on drug-induced arthritis.
Marwan H Adwan.
Rheumatol Int, 2016 Mar 24; 36(8). PMID: 27000044
Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.
Asaf Spiegel, Mary W Brooks, +14 authors, Robert A Weinberg.
Cancer Discov, 2016 Apr 14; 6(6). PMID: 27072748    Free PMC article.
Highly Cited.
Computational cell analysis for label-free detection of cell properties in a microfluidic laminar flow.
Alex Ce Zhang, Yi Gu, +5 authors, Yu-Hwa Lo.
Analyst, 2016 May 11; 141(13). PMID: 27163941    Free PMC article.
BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models.
Srikanth R Ambati, Jae-Hung Shieh, +6 authors, Malcolm A S Moore.
Oncotarget, 2016 Jun 02; 7(28). PMID: 27248664    Free PMC article.
Relationship between severity and duration of chemotherapy-induced neutropenia and risk of infection among patients with nonmyeloid malignancies.
Yanli Li, Zandra Klippel, +3 authors, John H Page.
Support Care Cancer, 2016 Jun 10; 24(10). PMID: 27278272
Neutrophils in cancer: neutral no more.
Seth B Coffelt, Max D Wellenstein, Karin E de Visser.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282249
Highly Cited. Review.
Burden of Chemotherapy-Induced Febrile Neutropenia Hospitalizations in US Clinical Practice, by Use and Patterns of Prophylaxis with Colony-Stimulating Factor.
Derek Weycker, Xiaoyan Li, +5 authors, Gary H Lyman.
Support Care Cancer, 2016 Oct 14; 25(2). PMID: 27734153
Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality.
Lin Li, Xiaotian Qi, +12 authors, Lingtao Wu.
EMBO Mol Med, 2016 Nov 04; 8(11). PMID: 27737899    Free PMC article.
Compatibility of Biosimilar Filgrastim with Cytotoxic Chemotherapy during the Treatment of Malignant Diseases (VENICE): A Prospective, Multicenter, Non-Interventional, Longitudinal Study.
Stefan Fruehauf, Burkhard Otremba, Oliver Stötzer, Christine Rudolph.
Adv Ther, 2016 Oct 28; 33(11). PMID: 27743353    Free PMC article.
Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity.
Merriline Satyamitra, Vidya P Kumar, +4 authors, Sanchita P Ghosh.
Radiat Res, 2017 Apr 01; 187(6). PMID: 28362168    Free PMC article.
Meta-analysis and indirect treatment comparison of lipegfilgrastim with pegfilgrastim and filgrastim for the reduction of chemotherapy-induced neutropenia-related events.
T Christopher Bond, Erika Szabo, +5 authors, Boxiong Tang.
J Oncol Pharm Pract, 2017 Jun 16; 24(6). PMID: 28614980    Free PMC article.
A stakeholder-informed randomized, controlled comparative effectiveness study of an order prescribing intervention to improve colony stimulating factor use for cancer patients receiving myelosuppressive chemotherapy: the TrACER study.
Aasthaa Bansal, Sean D Sullivan, +4 authors, Scott D Ramsey.
J Comp Eff Res, 2017 Jul 08; 6(5). PMID: 28686055    Free PMC article.
Vivek Srivastava, Rajat Kumar.
Med J Armed Forces India, 1997 Jul 01; 53(3). PMID: 28769495    Free PMC article.
A systematic literature review of the efficacy, effectiveness, and safety of filgrastim.
David C Dale, Jeffrey Crawford, +6 authors, Gary H Lyman.
Support Care Cancer, 2017 Sep 25; 26(1). PMID: 28939926    Free PMC article.
Systematic Review.
Cost-Utility Analysis of Lipegfilgrastim Compared to Pegfilgrastim for the Prophylaxis of Chemotherapy-Induced Neutropenia in Patients with Stage II-IV Breast Cancer.
Esse I H Akpo, Irshaad R Jansen, Edith Maes, Steven Simoens.
Front Pharmacol, 2017 Sep 29; 8. PMID: 28955224    Free PMC article.
Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.
Sadhna O Piryani, Angel Y F Kam, +6 authors, Phuong L Doan.
Stem Cells, 2017 Nov 01; 36(2). PMID: 29086459    Free PMC article.
Model-based optimization of G-CSF treatment during cytotoxic chemotherapy.
Sibylle Schirm, Christoph Engel, +2 authors, Markus Scholz.
J Cancer Res Clin Oncol, 2017 Nov 06; 144(2). PMID: 29103159    Free PMC article.
Severity and predictive factors of adverse events in pemetrexed-containing chemotherapy for non-small cell lung cancer.
Tsuyoshi Miyahara, Naoko Sueoka-Aragane, +7 authors, Shinya Kimura.
Med Oncol, 2017 Nov 11; 34(12). PMID: 29124473
NOLAN: a randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim.
Jeffrey J Kirshner, Maxwell C McDonald, +7 authors, Phuong Khanh Morrow.
Support Care Cancer, 2017 Nov 18; 26(4). PMID: 29147854    Free PMC article.
Effectiveness and Safety of Pegfilgrastim in BEP Treatment for Patients with Germ Cell Tumor.
Hiroaki Iwamoto, Kouji Izumi, +5 authors, Atsushi Mizokami.
In Vivo, 2018 Jun 25; 32(4). PMID: 29936477    Free PMC article.
Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects.
Roumen Nakov, Sreekanth Gattu, +3 authors, Andrej Skerjanec.
Br J Clin Pharmacol, 2018 Aug 07; 84(12). PMID: 30079636    Free PMC article.
Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers.
Chungam Choi, Byung Won Yoo, +5 authors, Min Soo Park.
Drug Des Devel Ther, 2018 Aug 21; 12. PMID: 30122896    Free PMC article.
Appropriateness of granulocyte colony-stimulating factor use in patients receiving chemotherapy by febrile neutropenia risk level.
Hassam Baig, Barbara Somlo, +3 authors, Phuong K Morrow.
J Oncol Pharm Pract, 2018 Sep 12; 25(7). PMID: 30200842    Free PMC article.
Granulocyte-colony stimulating factor and umbilical cord blood cell transplantation: Synergistic therapies for the treatment of traumatic brain injury.
Michael G Liska, Ike Dela Peña.
Brain Circ, 2017 Jul 01; 3(3). PMID: 30276316    Free PMC article.
Pharmacokinetic-Pharmacodynamic Model of Neutropenia in Patients With Myeloma Receiving High-Dose Melphalan for Autologous Stem Cell Transplant.
Yu Kyoung Cho, Donald J Irby, +11 authors, Mitch A Phelps.
CPT Pharmacometrics Syst Pharmacol, 2018 Oct 22; 7(11). PMID: 30343510    Free PMC article.
Home administration of filgrastim (Nivestim™) in primary prophylaxis of chemotherapy-induced febrile neutropenia.
Burkhard Otremba, Carsten Hielscher, Volker Petersen, Christian Petrik.
Patient Prefer Adherence, 2018 Nov 10; 12. PMID: 30410313    Free PMC article.
Biosimilar filgrastim treatment patterns and prevention of febrile neutropenia: a prospective multicentre study in France in patients with solid tumours (the ZOHé study).
Henri Roché, Jean-Christophe Eymard, +6 authors, Alain Toledano.
BMC Cancer, 2018 Nov 18; 18(1). PMID: 30445935    Free PMC article.
Filgrastim prophylaxis in elderly cancer patients in the real-life setting: a French multicenter observational study, the TULIP study.
Kamel Laribi, Delphine Badinand, +5 authors, Rafik Diab.
Support Care Cancer, 2019 Mar 16; 27(11). PMID: 30874925    Free PMC article.
Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.
Hisham Abdel-Azim, Weili Sun, Lingtao Wu.
Pharmacol Ther, 2019 Aug 31; 204. PMID: 31470030    Free PMC article.
Efficacy and tolerability of granulocyte colony-stimulating factors in cancer patients after chemotherapy: A systematic review and Bayesian network meta-analysis.
Yong Wang, Lin Chen, +4 authors, Yong Li.
Sci Rep, 2019 Oct 28; 9(1). PMID: 31653961    Free PMC article.
Systematic Review.
A method to determine if more than surrogate outcomes were improved: The EMR glitch experiment.
Jennifer Gill, Vinay Prasad.
Res Pract Thromb Haemost, 2020 Jan 29; 4(1). PMID: 31989081    Free PMC article.
A Survey of Oncologists' Perceptions and Opinions Regarding the Use of Granulocyte Colony-Stimulating Factors.
Alicia Hawkins, Alysa Murphy, +3 authors, Michael A Kelsh.
J Cancer Educ, 2019 Oct 28; 35(1). PMID: 31656028    Free PMC article.
Expression profiling revealed keratins and interleukins as potential biomarkers in squamous cell carcinoma of horn in Indian bullocks (Bos indicus).
Ketankumar Panchal, Prakash Koringa, +3 authors, Chaitanya Joshi.
3 Biotech, 2020 Feb 25; 10(3). PMID: 32089987    Free PMC article.
Automated detection of neutropenia using noninvasive video microscopy of superficial capillaries.
Alberto Pablo-Trinidad, Ian Butterworth, +14 authors, Aurélien Bourquard.
Am J Hematol, 2019 May 24; 94(8). PMID: 31120579    Free PMC article.
Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma.
Gregory S Calip, Kellyn M Moran, +7 authors, Brian C-H Chiu.
Cancer, 2018 Dec 15; 125(7). PMID: 30548485    Free PMC article.
Efficacy of Jackfruit365™ Green Jackfruit Flour Fortified Diet on Pegfilgrastim to Prevent Chemotherapy-Induced Leukopenia, Irrespective of Tumor Type or Drugs Used-A Retrospective Study.
Thomas Varughese, James Joseph, Rejeesh Menon.
Biomolecules, 2020 Feb 07; 10(2). PMID: 32024271    Free PMC article.
Biological response modifiers and infectious diseases: actual and potential therapeutic agents.
J J Rusthoven.
Int J Antimicrob Agents, 1994 Jan 01; 3(4). PMID: 18611565    Free PMC article.
Granulopoiesis-stimulating factors to prevent adverse effects in the treatment of malignant lymphoma.
Julia Bohlius, Christine Herbst, +2 authors, Andreas Engert.
Cochrane Database Syst Rev, 2008 Oct 10; (4). PMID: 18843642    Free PMC article.
Systematic Review.
Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors.
Philip Riley, Anne-Marie Glenny, +4 authors, Martin G McCabe.
Cochrane Database Syst Rev, 2017 Nov 29; 11. PMID: 29181845    Free PMC article.
Systematic Review.
Trends in the use of primary prophylactic colony-stimulating factors and neutropenia-related hospitalization in elderly cancer patients receiving myelosuppressive chemotherapy in the USA: 1995-2015.
Shuling Li, Jiannong Liu, +4 authors, David Chandler.
Support Care Cancer, 2019 Oct 19; 28(6). PMID: 31624920
Biosimilar Pegfilgrastim: Improving Access and Optimising Practice to Supportive Care that Enables Cure.
Paul Cornes, Pere Gascon, Arnold G Vulto, Matti Aapro.
BioDrugs, 2020 Apr 02; 34(3). PMID: 32232676    Free PMC article.
The top 100 cited articles in lung cancer - a bibliometric analysis.
Nilay Sengul Samanci, Emir Celik.
Contemp Oncol (Pozn), 2020 Jun 10; 24(1). PMID: 32514234    Free PMC article.
A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer.
Montreh Tavakkoli, Cy R Wilkins, Jodi V Mones, Michael J Mauro.
Front Oncol, 2019 May 14; 9. PMID: 31080780    Free PMC article.
Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy.
Nicole Skoetz, Julia Bohlius, +3 authors, Jörg-Janne Vehreschild.
Cochrane Database Syst Rev, 2015 Dec 22; (12). PMID: 26687844    Free PMC article.
Systematic Review.
Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With Non-Small Cell Lung Cancer: A Phase 2 Randomized Clinical Trial.
Douglas W Blayney, Qingyuan Zhang, +13 authors, Yuan-Kai Shi.
JAMA Oncol, 2020 Sep 25; 6(11). PMID: 32970104    Free PMC article.
Predicting neutropenia risk in patients with cancer using electronic data.
Pamala A Pawloski, Avis J Thomas, +3 authors, Gary H Lyman.
J Am Med Inform Assoc, 2016 Sep 18; 24(e1). PMID: 27638907    Free PMC article.
Comparative effectiveness of white blood cell growth factors on neutropenia, infection, and survival in older people with non-Hodgkin's lymphoma treated with chemotherapy.
Stephen K Gruschkus, David Lairson, +2 authors, Xianglin L Du.
J Am Geriatr Soc, 2010 Sep 16; 58(10). PMID: 20840455    Free PMC article.
A single-arm, retrospective analysis of the incidence of febrile neutropenia using same-day versus next-day pegfilgrastim in patients with gastrointestinal cancers treated with FOLFOX or FOLFIRI.
John Eckstrom, Trace Bartels, +6 authors, Ali McBride.
Support Care Cancer, 2018 Aug 10; 27(3). PMID: 30090991
Risk of chemotherapy-induced febrile neutropenia in patients with metastatic cancer not receiving granulocyte colony-stimulating factor prophylaxis in US clinical practice.
Ahuva Averin, Amanda Silvia, +8 authors, Derek Weycker.
Support Care Cancer, 2020 Sep 04; 29(4). PMID: 32880732    Free PMC article.
Randomized and dose-escalation trials of recombinant human serum albumin /granulocyte colony-stimulating factor in patients with breast cancer receiving anthracycline-containing chemotherapy.
Shanshan Chen, Yiqun Han, +15 authors, Binghe Xu.
BMC Cancer, 2021 Apr 02; 21(1). PMID: 33789616    Free PMC article.
Development and Internal Validation of a Nomogram Used to Predict Chemotherapy-Induced Neutropenia in Non-Small Cell Lung Cancer Patients: A Retrospective Cohort Study.
Wei Zou, Neng-Luan Xu.
Cancer Manag Res, 2021 Apr 06; 13. PMID: 33814928    Free PMC article.
G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation.
Ioannis Karagiannidis, Eralda Salataj, Erika Said Abu Egal, Ellen J Beswick.
Cytokine, 2021 Mar 08; 142. PMID: 33677228    Free PMC article.
Administration of docetaxel plus ramucirumab with primary prophylactic pegylated-granulocyte colony-stimulating factor for pretreated non-small cell lung cancer: a phase II study.
Norimitsu Kasahara, Noriaki Sunaga, +16 authors, Takeshi Hisada.
Support Care Cancer, 2020 Jan 27; 28(10). PMID: 31982960
Neutrophil-to-lymphocyte ratio in malignant pleural fluid: Prognostic significance.
Natalia Popowicz, Hui Min Cheah, +4 authors, Jenette Creaney.
PLoS One, 2021 Apr 27; 16(4). PMID: 33901252    Free PMC article.
A retrospective analysis of nadir-neutropenia directed pegylated granulocyte-colony stimulating factor on febrile neutropenia rates in (neo)adjuvant breast cancer chemotherapy regimens.
Sarah J Zardawi, Ina Nordman, Nicholas Zdenkowski.
Cancer Rep (Hoboken), 2020 Aug 08; 3(5). PMID: 32761893    Free PMC article.
Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma.
Takahiro Kametani, Yuichiro Otani, +13 authors, Masanori Ito.
Intern Med, 2020 Nov 17; 60(8). PMID: 33191326    Free PMC article.
Febrile neutropenia and role of prophylactic granulocyte colony-stimulating factor in docetaxel and cyclophosphamide chemotherapy for breast cancer.
Yuri Kimura, Shinsuke Sasada, +3 authors, Morihito Okada.
Support Care Cancer, 2020 Nov 05; 29(7). PMID: 33146835
Preclinical immunogenicity testing using anti-drug antibody analysis of GX-G3, Fc-fused recombinant human granulocyte colony-stimulating factor, in rat and monkey models.
Yun Jung Kim, Eun Mi Koh, +7 authors, Kyung Jin Jung.
Sci Rep, 2021 Jun 09; 11(1). PMID: 34099775    Free PMC article.
Pooled Analysis on the Effectiveness and Safety of Lipegfilgrastim in Patients With Urological Malignancies in the Real-World Setting.
Axel S Merseburger, Götz Geiges, +2 authors, Petra Pichler.
Front Oncol, 2021 Jun 15; 11. PMID: 34123810    Free PMC article.
Systematic Review.
Effectiveness of Herbal Medicine for Leukopenia/Neutropenia Induced by Chemotherapy in Adults with Colorectal Cancer: A Systematic Review and Meta-analysis.
Shao-Hua Yan, Shuo Feng, +11 authors, Yu-Fei Yang.
Integr Cancer Ther, 2021 Jun 13; 20. PMID: 34116595    Free PMC article.