Journal Article
. 1991 Jul; 325(3):164-70.
doi: 10.1056/NEJM199107183250305.

Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer

J Crawford 1 H Ozer  R Stoller  D Johnson  G Lyman  I Tabbara  M Kris  J Grous  V Picozzi  G Rausch  
Affiliations
  • PMID: 1711156
  •     234 citations

Abstract

Background: Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients with cancer. We conducted a randomized clinical trial to test this hypothesis and the clinical implications.

Methods: Patients with small-cell lung cancer were enrolled in a multicenter, randomized, double-blind, placebo-controlled trial of recombinant methionyl G-CSF to study the incidence of infection as manifested by fever with neutropenia (absolute neutrophil count, less than 1.0 x 10(9) per liter, with a temperature greater than or equal to 38.2 degrees C) resulting from up to six cycles of chemotherapy with cyclophosphamide, doxorubicin, and etoposide. The patients were randomly assigned to receive either placebo or G-CSF, with treatment beginning on day 4 and continuing through day 17 of a 21-day cycle.

Results: The safety of the study treatment could be evaluated in 207 of the 211 patients assigned to either drug, and its efficacy in 199. At least one episode of fever with neutropenia occurred in 77 percent of the placebo group, as compared with 40 percent of the G-CSF group (P less than 0.001). Over all cycles of chemotherapy, the median duration of grade IV neutropenia (absolute neutrophil count, less than 0.5 x 10(9) per liter) was six days with placebo as compared with one day with G-CSF. During cycles of blinded treatment, the number of days of treatment with intravenous antibiotics, the number of days of hospitalization, and the incidence of confirmed infections were reduced by approximately 50 percent when G-CSF was given, as compared with placebo. Mild-to-moderate medullary bone pain occurred in 20 percent of the patients receiving G-CSF.

Conclusions: The use of G-CSF as an adjunct to chemotherapy in patients with small-cell cancer of the lung was well tolerated and led to reductions in the incidence of fever with neutropenia and culture-confirmed infections; in the incidence, duration, and severity of grade IV neutropenia; and in the total number of days of treatment with intravenous antibiotics and days of hospitalization.

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Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer.
Andrea L Merz, Natalie J Serkova.
Biomark Med, 2010 Feb 18; 3(3). PMID: 20160999    Free PMC article.
Development and validation of a prediction model for the risk of developing febrile neutropenia in the first cycle of chemotherapy among elderly patients with breast, lung, colorectal, and prostate cancer.
Wylie Hosmer, Jennifer Malin, Mitchell Wong.
Support Care Cancer, 2010 Feb 25; 19(3). PMID: 20179995    Free PMC article.
Prophylaxis of chemotherapy-induced febrile neutropenia with granulocyte colony-stimulating factors: where are we now?
Matti Aapro, Jeffrey Crawford, Didier Kamioner.
Support Care Cancer, 2010 Mar 02; 18(5). PMID: 20191292    Free PMC article.
The colony-stimulating factors and cancer.
Donald Metcalf.
Nat Rev Cancer, 2010 May 25; 10(6). PMID: 20495576    Free PMC article.
Review.
Pegfilgrastim on the Same Day Versus Next Day of Chemotherapy in Patients With Breast Cancer, Non-Small-Cell Lung Cancer, Ovarian Cancer, and Non-Hodgkin's Lymphoma: Results of Four Multicenter, Double-Blind, Randomized Phase II Studies.
Howard A Burris, Chandra P Belani, +6 authors, Alan Saven.
J Oncol Pract, 2010 Sep 03; 6(3). PMID: 20808556    Free PMC article.
How we treat febrile neutropenia in patients receiving cancer chemotherapy.
Gary H Lyman, Kenneth V I Rolston.
J Oncol Pract, 2010 Sep 03; 6(3). PMID: 20808559    Free PMC article.
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.
Marcin Kowanetz, Xiumin Wu, +18 authors, Napoleone Ferrara.
Proc Natl Acad Sci U S A, 2010 Nov 18; 107(50). PMID: 21081700    Free PMC article.
Highly Cited.
Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy.
Gary H Lyman, Nicole M Kuderer, +4 authors, David C Dale.
Cancer, 2011 Apr 22; 117(9). PMID: 21509769    Free PMC article.
Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae.
An-Bin Zhao, Bin Yu, +4 authors, Xiao-Yin Chen.
Pharmacogn Mag, 2011 Jul 01; 7(26). PMID: 21716623    Free PMC article.
Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis.
Katy L Cooper, Jason Madan, +2 authors, Ron L Akehurst.
BMC Cancer, 2011 Sep 29; 11. PMID: 21943360    Free PMC article.
Systematic Review.
Re: personalized medicine and cancer supportive care: appropriate use of colony-stimulating factor support of chemotherapy.
Arnold L Potosky, Jennifer L Malin, +2 authors, Jane C Weeks.
J Natl Cancer Inst, 2011 Nov 01; 103(24). PMID: 22036767    Free PMC article.
Aurora kinase inhibitors: progress towards the clinic.
Madhu Kollareddy, Daniella Zheleva, +3 authors, Marian Hajduch.
Invest New Drugs, 2012 Feb 22; 30(6). PMID: 22350019    Free PMC article.
Highly Cited. Review.
A way forward on the medically appropriate use of white cell growth factors.
Thomas J Smith, Bruce E Hillner.
J Clin Oncol, 2012 Mar 01; 30(14). PMID: 22370327    Free PMC article.
Review.
Pharmacoeconomics of the myeloid growth factors: a critical and systematic review.
Bradford R Hirsch, Gary H Lyman.
Pharmacoeconomics, 2012 May 01; 30(6). PMID: 22540394
Systematic Review.
Treatment-related death in patients with small-cell lung cancer in phase III trials over the last two decades.
Nobuaki Ochi, Katsuyuki Hotta, +7 authors, Katsuyuki Kiura.
PLoS One, 2012 Aug 11; 7(8). PMID: 22880112    Free PMC article.
Guideline-Based Peer-to-Peer Consultation Optimizes Pegfilgrastim Use With No Adverse Clinical Consequences.
Marc L Fishman, Akhil Kumar, +2 authors, William J M Hrushesky.
J Oncol Pract, 2012 Sep 04; 8(3 Suppl). PMID: 22942828    Free PMC article.
Filgrastim improves survival in lethally irradiated nonhuman primates.
Ann M Farese, Melanie V Cohen, +4 authors, Thomas J MacVittie.
Radiat Res, 2012 Dec 06; 179(1). PMID: 23210705    Free PMC article.
Small cell lung cancer.
Gregory P Kalemkerian, Wallace Akerley, +24 authors, National Comprehensive Cancer Network.
J Natl Compr Canc Netw, 2013 Jan 12; 11(1). PMID: 23307984    Free PMC article.
Highly Cited.
Supportive therapy in medical therapy of head and neck tumors.
Hartmut Link.
GMS Curr Top Otorhinolaryngol Head Neck Surg, 2013 Jan 16; 11. PMID: 23320053    Free PMC article.
Neutropenia and G-CSF in lymphoproliferative diseases.
Roberto Ria, Antonia Reale, +2 authors, Angelo Vacca.
Hematology, 2013 Jan 17; 18(3). PMID: 23321273    Free PMC article.
Effectiveness of daily versus non-daily granulocyte colony-stimulating factors in patients with solid tumours undergoing chemotherapy: a multivariate analysis of data from current practice.
D Almenar Cubells, C Bosch Roig, +8 authors, LEARN II Study Group.
Eur J Cancer Care (Engl), 2013 Jan 22; 22(3). PMID: 23331323    Free PMC article.
Colony-stimulating factors for febrile neutropenia during cancer therapy.
Charles L Bennett, Benjamin Djulbegovic, LeAnn B Norris, James O Armitage.
N Engl J Med, 2013 Mar 22; 368(12). PMID: 23514290    Free PMC article.
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Real-world impact of granulocyte-colony stimulating factor on febrile neutropenia.
A K Altwairgi, W M Hopman, M Mates.
Curr Oncol, 2013 Jun 06; 20(3). PMID: 23737687    Free PMC article.
Efficacy and safety of lipegfilgrastim versus pegfilgrastim: a randomized, multicenter, active-control phase 3 trial in patients with breast cancer receiving doxorubicin/docetaxel chemotherapy.
Igor Bondarenko, Oleg A Gladkov, +2 authors, Peter Bias.
BMC Cancer, 2013 Aug 16; 13. PMID: 23945072    Free PMC article.
Epidemiology of chemotherapy-induced neutropenia at a tertiary university hospital in Oman.
Maram Abou Saleh, Rose Ngozi Mafiana, +3 authors, Ibrahim Al-Zakwani.
Int J Clin Pharm, 2013 Oct 09; 35(6). PMID: 24101032
Neutropenia management and granulocyte colony-stimulating factor use in patients with solid tumours receiving myelotoxic chemotherapy--findings from clinical practice.
K Krzemieniecki, P Sevelda, +7 authors, J Maenpaa.
Support Care Cancer, 2013 Oct 25; 22(3). PMID: 24154740    Free PMC article.
Study design: two long-term observational studies of the biosimilar filgrastim Nivestim™ (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia.
Didier Kamioner, Stefan Fruehauf, +3 authors, Christian Berthou.
BMC Cancer, 2013 Nov 19; 13. PMID: 24237790    Free PMC article.
Efficacy and safety analysis of once per cycle pegfilgrastim and daily lenograstim in patients with breast cancer receiving adjuvant myelosuppressive chemotherapy FEC 100: a pilot study.
Luigi Rossi, Federica Tomao, +10 authors, Silverio Tomao.
Ther Clin Risk Manag, 2013 Nov 21; 9. PMID: 24255599    Free PMC article.
Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.
Hui Lin Chua, P Artur Plett, +5 authors, Christie M Orschell.
Health Phys, 2013 Nov 28; 106(1). PMID: 24276547    Free PMC article.
A prospective observational study to evaluate G-CSF usage in patients with solid tumors receiving myelosuppressive chemotherapy in Italian clinical oncology practice.
S Barni, V Lorusso, +10 authors, P Pronzato.
Med Oncol, 2013 Dec 07; 31(1). PMID: 24307348
Clinical efficacy of adjunctive G-CSF on solid tumor and lymphoma patients with established febrile neutropenia.
Alexandre Chan, Qi Xuan Wong, +2 authors, Li Yang Hsu.
Support Care Cancer, 2013 Dec 10; 22(4). PMID: 24317848
Impact of granulocyte colony-stimulating factors in metastatic colorectal cancer patients.
A Amadio, R Burkes, +2 authors, B Coleman.
Curr Oncol, 2014 Feb 14; 21(1). PMID: 24523621    Free PMC article.
Severe neutropenia and relative dose intensity among patients<65 and ≥65 years with non-Hodgkin's lymphoma receiving CHOP-based chemotherapy.
Lee S Schwartzberg, Mansoor Saleh, Sadie Whittaker, Esteban Abella.
Support Care Cancer, 2014 Feb 19; 22(7). PMID: 24535242
Use of pegfilgrastim primary prophylaxis and risk of infection, by chemotherapy cycle and regimen, among patients with breast cancer or non-Hodgkin's lymphoma.
Wendy J Langeberg, Conchitina C Siozon, +2 authors, Victoria M Chia.
Support Care Cancer, 2014 Mar 22; 22(8). PMID: 24652049
Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study.
Eva Culakova, Ramya Thota, +5 authors, Gary H Lyman.
Cancer Med, 2014 Apr 08; 3(2). PMID: 24706592    Free PMC article.
Risk and consequences of chemotherapy-induced neutropenic complications in patients receiving daily filgrastim: the importance of duration of prophylaxis.
Derek Weycker, Rich Barron, +3 authors, Andrew G Glass.
BMC Health Serv Res, 2014 Apr 29; 14. PMID: 24767095    Free PMC article.
Leukemoid reaction and autocrine growth of bladder cancer induced by paraneoplastic production of granulocyte colony-stimulating factor--a potential neoplastic marker: a case report and review of the literature.
Anup Kasi Loknath Kumar, Megha Teeka Satyan, +2 authors, Peter Van Veldhuizen.
J Med Case Rep, 2014 Jun 03; 8. PMID: 24885603    Free PMC article.
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Septic shock due to community-acquired Pseudomonas aeruginosa necrotizing fasciitis: A case report and literature review.
Guang-Ju Zhao, Guang-Liang Hong, +2 authors, Zhong-Qiu Lu.
Exp Ther Med, 2014 Jun 14; 7(6). PMID: 24926341    Free PMC article.
Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial.
Benjamin Hibbert, Bradley Hayley, +13 authors, Christopher Glover.
CMAJ, 2014 Jun 18; 186(11). PMID: 24934893    Free PMC article.
Necrotizing fasciitis in a young patient with acute myeloid leukemia - a diagnostic challenge.
Mareen Brumann, Viktoria Bogner, +3 authors, Wolf Mutschler.
Patient Saf Surg, 2014 Jul 09; 8. PMID: 25002906    Free PMC article.
Understanding, treating and avoiding hematological disease: better medicine through mathematics?
David C Dale, Michael C Mackey.
Bull Math Biol, 2014 Sep 13; 77(5). PMID: 25213154    Free PMC article.
Granulocyte colony-stimulating factors as prophylaxis against febrile neutropenia.
Sol Cortés de Miguel, Miguel Ángel Calleja-Hernández, Salomón Menjón-Beltrán, Inmaculada Vallejo-Rodríguez.
Support Care Cancer, 2014 Oct 07; 23(2). PMID: 25284722
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Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia.
Laurence A Boxer, Audrey Anna Bolyard, +5 authors, David C Dale.
Obstet Gynecol, 2015 Jan 07; 125(1). PMID: 25560125    Free PMC article.
An open-label, randomized, multicenter dose-finding study of once-per-cycle pegfilgrastim versus daily filgrastim in Chinese breast cancer patients receiving TAC chemotherapy.
Wei Zhang, Zhiwei Jiang, +2 authors, Jielai Xia.
Med Oncol, 2015 Mar 31; 32(5). PMID: 25820754
The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials.
Li Wang, Onur Baser, +2 authors, Richard Barron.
Support Care Cancer, 2015 Mar 31; 23(11). PMID: 25821144    Free PMC article.
Systematic Review.
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
Ruth J Napier, Brian A Norris, +14 authors, Daniel Kalman.
PLoS Pathog, 2015 Mar 31; 11(3). PMID: 25822986    Free PMC article.
Phase II dose-finding study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy.
Oleg Gladkov, Vladimir Moiseyenko, +5 authors, Noa Avisar.
Med Oncol, 2015 May 15; 32(6). PMID: 25966791
Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor.
Tara Arvedson, James O'Kelly, Bing-Bing Yang.
BioDrugs, 2015 May 23; 29(3). PMID: 25998211    Free PMC article.
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A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects.
Liat Adar, Noa Avisar, +2 authors, Ofer Spiegelstein.
Drug Des Devel Ther, 2015 Jun 02; 9. PMID: 26028962    Free PMC article.
Risk factors for bone pain among patients with cancer receiving myelosuppressive chemotherapy and pegfilgrastim.
H Xu, Q Gong, +2 authors, J H Page.
Support Care Cancer, 2015 Jul 15; 24(2). PMID: 26162536
Immunotherapy treatments for small-cell lung cancer: past, present and future.
Matthew Whitehurst, Alberto Chiappori.
Lung Cancer Manag, 2013 Jan 01; 2(6). PMID: 26236401    Free PMC article.
G-CSF and GM-CSF in Neutropenia.
Hrishikesh M Mehta, Michael Malandra, Seth J Corey.
J Immunol, 2015 Aug 09; 195(4). PMID: 26254266    Free PMC article.
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Attitudes of physicians toward assessing risk and using granulocyte colony-stimulating factor as primary prophylaxis in patients receiving chemotherapy associated with an intermediate risk of febrile neutropenia.
Gilles Freyer, Ewa Kalinka-Warzocha, +9 authors, Zsolt Szabo.
Med Oncol, 2015 Sep 01; 32(10). PMID: 26315712
Investigation of the biological and anti-cancer properties of ellagic acid-encapsulated nano-sized metalla-cages.
Abhishek Dubey, Dae Won Park, +5 authors, Ki-Whan Chi.
Int J Nanomedicine, 2015 Sep 15; 10 Spec Iss. PMID: 26366074    Free PMC article.
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.
YanHe Lue, Ronald Swerdloff, +9 authors, Christina Wang.
Endocrinology, 2015 Sep 19; 156(12). PMID: 26384090    Free PMC article.
Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter?
Derek Weycker, Xiaoyan Li, +3 authors, May Hagiwara.
Support Care Cancer, 2015 Nov 27; 24(5). PMID: 26607482    Free PMC article.
Clinical safety of tbo-filgrastim, a short-acting human granulocyte colony-stimulating factor.
Ruth Pettengell, Peter Bias, Udo Mueller, Nicole Lang.
Support Care Cancer, 2016 Jan 19; 24(6). PMID: 26780505
Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients.
Roberto Guariglia, Maria Carmen Martorelli, +3 authors, Pellegrino Musto.
Biologics, 2016 Feb 10; 10. PMID: 26858523    Free PMC article.
Review.
Trajectory of absolute neutrophil counts in patients treated with pegfilgrastim on the day of chemotherapy versus the day after chemotherapy.
Yanli Li, Zandra Klippel, +3 authors, John H Page.
Cancer Chemother Pharmacol, 2016 Feb 18; 77(4). PMID: 26886017    Free PMC article.
Biosimilars in the management of neutropenia: focus on filgrastim.
Désirée Caselli, Simone Cesaro, Maurizio Aricò.
Biologics, 2016 Mar 05; 10. PMID: 26937170    Free PMC article.
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An update on drug-induced arthritis.
Marwan H Adwan.
Rheumatol Int, 2016 Mar 24; 36(8). PMID: 27000044
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Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.
Asaf Spiegel, Mary W Brooks, +14 authors, Robert A Weinberg.
Cancer Discov, 2016 Apr 14; 6(6). PMID: 27072748    Free PMC article.
Highly Cited.
Computational cell analysis for label-free detection of cell properties in a microfluidic laminar flow.
Alex Ce Zhang, Yi Gu, +5 authors, Yu-Hwa Lo.
Analyst, 2016 May 11; 141(13). PMID: 27163941    Free PMC article.
BO-1055, a novel DNA cross-linking agent with remarkable low myelotoxicity shows potent activity in sarcoma models.
Srikanth R Ambati, Jae-Hung Shieh, +6 authors, Malcolm A S Moore.
Oncotarget, 2016 Jun 02; 7(28). PMID: 27248664    Free PMC article.
Relationship between severity and duration of chemotherapy-induced neutropenia and risk of infection among patients with nonmyeloid malignancies.
Yanli Li, Zandra Klippel, +3 authors, John H Page.
Support Care Cancer, 2016 Jun 10; 24(10). PMID: 27278272
Neutrophils in cancer: neutral no more.
Seth B Coffelt, Max D Wellenstein, Karin E de Visser.
Nat Rev Cancer, 2016 Jun 11; 16(7). PMID: 27282249
Highly Cited. Review.
Burden of Chemotherapy-Induced Febrile Neutropenia Hospitalizations in US Clinical Practice, by Use and Patterns of Prophylaxis with Colony-Stimulating Factor.
Derek Weycker, Xiaoyan Li, +5 authors, Gary H Lyman.
Support Care Cancer, 2016 Oct 14; 25(2). PMID: 27734153
Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality.
Lin Li, Xiaotian Qi, +12 authors, Lingtao Wu.
EMBO Mol Med, 2016 Nov 04; 8(11). PMID: 27737899    Free PMC article.
Compatibility of Biosimilar Filgrastim with Cytotoxic Chemotherapy during the Treatment of Malignant Diseases (VENICE): A Prospective, Multicenter, Non-Interventional, Longitudinal Study.
Stefan Fruehauf, Burkhard Otremba, Oliver Stötzer, Christine Rudolph.
Adv Ther, 2016 Oct 28; 33(11). PMID: 27743353    Free PMC article.
Impact of Abbreviated Filgrastim Schedule on Survival and Hematopoietic Recovery after Irradiation in Four Mouse Strains with Different Radiosensitivity.
Merriline Satyamitra, Vidya P Kumar, +4 authors, Sanchita P Ghosh.
Radiat Res, 2017 Apr 01; 187(6). PMID: 28362168    Free PMC article.
Meta-analysis and indirect treatment comparison of lipegfilgrastim with pegfilgrastim and filgrastim for the reduction of chemotherapy-induced neutropenia-related events.
T Christopher Bond, Erika Szabo, +5 authors, Boxiong Tang.
J Oncol Pharm Pract, 2017 Jun 16; 24(6). PMID: 28614980    Free PMC article.
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A stakeholder-informed randomized, controlled comparative effectiveness study of an order prescribing intervention to improve colony stimulating factor use for cancer patients receiving myelosuppressive chemotherapy: the TrACER study.
Aasthaa Bansal, Sean D Sullivan, +4 authors, Scott D Ramsey.
J Comp Eff Res, 2017 Jul 08; 6(5). PMID: 28686055    Free PMC article.
ROLE OF HAEMATOPOIETIC GROWTH FACTORS IN MEDICINE.
Vivek Srivastava, Rajat Kumar.
Med J Armed Forces India, 1997 Jul 01; 53(3). PMID: 28769495    Free PMC article.
A systematic literature review of the efficacy, effectiveness, and safety of filgrastim.
David C Dale, Jeffrey Crawford, +6 authors, Gary H Lyman.
Support Care Cancer, 2017 Sep 25; 26(1). PMID: 28939926    Free PMC article.
Systematic Review.
Cost-Utility Analysis of Lipegfilgrastim Compared to Pegfilgrastim for the Prophylaxis of Chemotherapy-Induced Neutropenia in Patients with Stage II-IV Breast Cancer.
Esse I H Akpo, Irshaad R Jansen, Edith Maes, Steven Simoens.
Front Pharmacol, 2017 Sep 29; 8. PMID: 28955224    Free PMC article.
Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.
Sadhna O Piryani, Angel Y F Kam, +6 authors, Phuong L Doan.
Stem Cells, 2017 Nov 01; 36(2). PMID: 29086459    Free PMC article.
Model-based optimization of G-CSF treatment during cytotoxic chemotherapy.
Sibylle Schirm, Christoph Engel, +2 authors, Markus Scholz.
J Cancer Res Clin Oncol, 2017 Nov 06; 144(2). PMID: 29103159    Free PMC article.
Severity and predictive factors of adverse events in pemetrexed-containing chemotherapy for non-small cell lung cancer.
Tsuyoshi Miyahara, Naoko Sueoka-Aragane, +7 authors, Shinya Kimura.
Med Oncol, 2017 Nov 11; 34(12). PMID: 29124473
NOLAN: a randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim.
Jeffrey J Kirshner, Maxwell C McDonald, +7 authors, Phuong Khanh Morrow.
Support Care Cancer, 2017 Nov 18; 26(4). PMID: 29147854    Free PMC article.
Effectiveness and Safety of Pegfilgrastim in BEP Treatment for Patients with Germ Cell Tumor.
Hiroaki Iwamoto, Kouji Izumi, +5 authors, Atsushi Mizokami.
In Vivo, 2018 Jun 25; 32(4). PMID: 29936477    Free PMC article.
Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects.
Roumen Nakov, Sreekanth Gattu, +3 authors, Andrej Skerjanec.
Br J Clin Pharmacol, 2018 Aug 07; 84(12). PMID: 30079636    Free PMC article.
Comparison of biosimilar filgrastim with a reference product: pharmacokinetics, pharmacodynamics, and safety profiles in healthy volunteers.
Chungam Choi, Byung Won Yoo, +5 authors, Min Soo Park.
Drug Des Devel Ther, 2018 Aug 21; 12. PMID: 30122896    Free PMC article.
Appropriateness of granulocyte colony-stimulating factor use in patients receiving chemotherapy by febrile neutropenia risk level.
Hassam Baig, Barbara Somlo, +3 authors, Phuong K Morrow.
J Oncol Pharm Pract, 2018 Sep 12; 25(7). PMID: 30200842    Free PMC article.
Granulocyte-colony stimulating factor and umbilical cord blood cell transplantation: Synergistic therapies for the treatment of traumatic brain injury.
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Brain Circ, 2017 Jul 01; 3(3). PMID: 30276316    Free PMC article.
Review.
Pharmacokinetic-Pharmacodynamic Model of Neutropenia in Patients With Myeloma Receiving High-Dose Melphalan for Autologous Stem Cell Transplant.
Yu Kyoung Cho, Donald J Irby, +11 authors, Mitch A Phelps.
CPT Pharmacometrics Syst Pharmacol, 2018 Oct 22; 7(11). PMID: 30343510    Free PMC article.
Home administration of filgrastim (Nivestim™) in primary prophylaxis of chemotherapy-induced febrile neutropenia.
Burkhard Otremba, Carsten Hielscher, Volker Petersen, Christian Petrik.
Patient Prefer Adherence, 2018 Nov 10; 12. PMID: 30410313    Free PMC article.
Biosimilar filgrastim treatment patterns and prevention of febrile neutropenia: a prospective multicentre study in France in patients with solid tumours (the ZOHé study).
Henri Roché, Jean-Christophe Eymard, +6 authors, Alain Toledano.
BMC Cancer, 2018 Nov 18; 18(1). PMID: 30445935    Free PMC article.
Filgrastim prophylaxis in elderly cancer patients in the real-life setting: a French multicenter observational study, the TULIP study.
Kamel Laribi, Delphine Badinand, +5 authors, Rafik Diab.
Support Care Cancer, 2019 Mar 16; 27(11). PMID: 30874925    Free PMC article.
Strategies to generate functionally normal neutrophils to reduce infection and infection-related mortality in cancer chemotherapy.
Hisham Abdel-Azim, Weili Sun, Lingtao Wu.
Pharmacol Ther, 2019 Aug 31; 204. PMID: 31470030    Free PMC article.
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Efficacy and tolerability of granulocyte colony-stimulating factors in cancer patients after chemotherapy: A systematic review and Bayesian network meta-analysis.
Yong Wang, Lin Chen, +4 authors, Yong Li.
Sci Rep, 2019 Oct 28; 9(1). PMID: 31653961    Free PMC article.
Systematic Review.
A method to determine if more than surrogate outcomes were improved: The EMR glitch experiment.
Jennifer Gill, Vinay Prasad.
Res Pract Thromb Haemost, 2020 Jan 29; 4(1). PMID: 31989081    Free PMC article.
A Survey of Oncologists' Perceptions and Opinions Regarding the Use of Granulocyte Colony-Stimulating Factors.
Alicia Hawkins, Alysa Murphy, +3 authors, Michael A Kelsh.
J Cancer Educ, 2019 Oct 28; 35(1). PMID: 31656028    Free PMC article.
Expression profiling revealed keratins and interleukins as potential biomarkers in squamous cell carcinoma of horn in Indian bullocks (Bos indicus).
Ketankumar Panchal, Prakash Koringa, +3 authors, Chaitanya Joshi.
3 Biotech, 2020 Feb 25; 10(3). PMID: 32089987    Free PMC article.
Automated detection of neutropenia using noninvasive video microscopy of superficial capillaries.
Alberto Pablo-Trinidad, Ian Butterworth, +14 authors, Aurélien Bourquard.
Am J Hematol, 2019 May 24; 94(8). PMID: 31120579    Free PMC article.
Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma.
Gregory S Calip, Kellyn M Moran, +7 authors, Brian C-H Chiu.
Cancer, 2018 Dec 15; 125(7). PMID: 30548485    Free PMC article.
Efficacy of Jackfruit365™ Green Jackfruit Flour Fortified Diet on Pegfilgrastim to Prevent Chemotherapy-Induced Leukopenia, Irrespective of Tumor Type or Drugs Used-A Retrospective Study.
Thomas Varughese, James Joseph, Rejeesh Menon.
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Granulopoiesis-stimulating factors to prevent adverse effects in the treatment of malignant lymphoma.
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Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors.
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Systematic Review.
Trends in the use of primary prophylactic colony-stimulating factors and neutropenia-related hospitalization in elderly cancer patients receiving myelosuppressive chemotherapy in the USA: 1995-2015.
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Support Care Cancer, 2019 Oct 19; 28(6). PMID: 31624920
Biosimilar Pegfilgrastim: Improving Access and Optimising Practice to Supportive Care that Enables Cure.
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The top 100 cited articles in lung cancer - a bibliometric analysis.
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A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer.
Montreh Tavakkoli, Cy R Wilkins, Jodi V Mones, Michael J Mauro.
Front Oncol, 2019 May 14; 9. PMID: 31080780    Free PMC article.
Prophylactic antibiotics or G(M)-CSF for the prevention of infections and improvement of survival in cancer patients receiving myelotoxic chemotherapy.
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