Journal Article
. 2007 Jan; 8(3):277-84.
doi: 10.1038/ni1437.

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

Luke M Williams 1 Alexander Y Rudensky  
Affiliations
  • PMID: 17220892
  •     356 citations

Abstract

The transcription factor Foxp3 is required for the development of regulatory T cells (T(reg) cell). Here we report that induced ablation of a loxP-flanked Foxp3 allele in mature T(reg) cells resulted in the loss of their suppressive function in vivo and acquisition of the ability to produce interleukin 2 and T helper type 1 cytokines. Furthermore, after adoptive transfer in the absence of functional T(reg) cells into lymphopenic hosts, T(reg) cells with deletion of Foxp3 proliferated and were predominant among tissue-infiltrating T cells. In agreement with those results, we found deregulation of Foxp3 target gene expression after Foxp3 deletion. Thus, continued Foxp3 expression in mature T(reg) cells is needed to maintain the transcriptional and functional program established during T(reg) cell development.

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Cancer J, 2012 Feb 01; 18(1). PMID: 22290259    Free PMC article.
Review.
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
Hye-Sook Kwon, Hyung W Lim, +3 authors, Melanie Ott.
J Immunol, 2012 Feb 09; 188(6). PMID: 22312127    Free PMC article.
Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells.
D Tischner, G J Wiegers, +2 authors, A Villunger.
Cell Death Differ, 2012 Feb 11; 19(8). PMID: 22322859    Free PMC article.
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.
Xin Gao, Yibei Zhu, +7 authors, Binfeng Lu.
PLoS One, 2012 Mar 01; 7(2). PMID: 22363469    Free PMC article.
Highly Cited.
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.
Garima Garg, Jennifer R Tyler, +9 authors, Timothy I M Tree.
J Immunol, 2012 Mar 31; 188(9). PMID: 22461703    Free PMC article.
Highly Cited.
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Matthew L Bettini, Fan Pan, +8 authors, Dario A A Vignali.
Immunity, 2012 May 15; 36(5). PMID: 22579476    Free PMC article.
Highly Cited.
Maintaining differentiated cellular identity.
Johan Holmberg, Thomas Perlmann.
Nat Rev Genet, 2012 May 19; 13(6). PMID: 22596319
Review.
Cellular and molecular determinants for the development of natural and induced regulatory T cells.
Xiaomei Yuan, Thomas R Malek.
Hum Immunol, 2012 Jun 05; 73(8). PMID: 22659217    Free PMC article.
Review.
Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy.
Ravi S Swamy, Neha Reshamwala, +7 authors, Kari C Nadeau.
J Allergy Clin Immunol, 2012 Jun 09; 130(1). PMID: 22677046    Free PMC article.
The effects of TLR activation on T-cell development and differentiation.
Bo Jin, Tao Sun, +2 authors, Anthony E T Yeo.
Clin Dev Immunol, 2012 Jun 28; 2012. PMID: 22737174    Free PMC article.
Review.
Transcription factor Foxp3 and its protein partners form a complex regulatory network.
Dipayan Rudra, Paul deRoos, +7 authors, Alexander Y Rudensky.
Nat Immunol, 2012 Aug 28; 13(10). PMID: 22922362    Free PMC article.
Highly Cited.
T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
Meghan A Koch, Kerri R Thomas, +3 authors, Daniel J Campbell.
Immunity, 2012 Sep 11; 37(3). PMID: 22960221    Free PMC article.
Highly Cited.
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of  T Cell Activation.
Hanna Bendfeldt, Manuela Benary, +4 authors, Ria Baumgrass.
Front Immunol, 2012 Sep 13; 3. PMID: 22969764    Free PMC article.
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Frederico S Regateiro, Ye Chen, +12 authors, Duncan Howie.
J Immunol, 2012 Sep 19; 189(8). PMID: 22988034    Free PMC article.
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.
Robert M Samstein, Aaron Arvey, +11 authors, Alexander Y Rudensky.
Cell, 2012 Oct 02; 151(1). PMID: 23021222    Free PMC article.
Highly Cited.
FOXP3, CBLB and ITCH gene expression and cytotoxic T lymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosis.
F Sellebjerg, M Krakauer, +2 authors, P S Sørensen.
Clin Exp Immunol, 2012 Oct 09; 170(2). PMID: 23039885    Free PMC article.
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus.
Lisa A Reynolds, Kara J Filbey, Rick M Maizels.
Semin Immunopathol, 2012 Oct 12; 34(6). PMID: 23053394    Free PMC article.
Review.
Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunity.
Federica Barzaghi, Laura Passerini, Rosa Bacchetta.
Front Immunol, 2012 Oct 13; 3. PMID: 23060872    Free PMC article.
Highly Cited.
Mechanism of oral tolerance induction to therapeutic proteins.
Xiaomei Wang, Alexandra Sherman, +4 authors, Roland W Herzog.
Adv Drug Deliv Rev, 2012 Nov 06; 65(6). PMID: 23123293    Free PMC article.
Review.
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.
Tuure Kinnunen, Nicolas Chamberlain, +10 authors, Eric Meffre.
Blood, 2012 Dec 12; 121(9). PMID: 23223361    Free PMC article.
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.
Guoyan Cheng, Aixin Yu, Michael J Dee, Thomas R Malek.
J Immunol, 2013 Jan 15; 190(4). PMID: 23315074    Free PMC article.
Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?
Stephanie M Coomes, Victoria S Pelly, Mark S Wilson.
Open Biol, 2013 Jan 25; 3(1). PMID: 23345540    Free PMC article.
Review.
Control of inflammation by integration of environmental cues by regulatory T cells.
Ashutosh Chaudhry, Alexander Y Rudensky.
J Clin Invest, 2013 Mar 05; 123(3). PMID: 23454755    Free PMC article.
Highly Cited. Review.
Mechanisms of regulatory T cell counter-regulation by innate immunity.
Heidi Yeh, Daniel J Moore, James F Markmann, James I Kim.
Transplant Rev (Orlando), 2013 Mar 12; 27(2). PMID: 23474287    Free PMC article.
Review.
Regulators of chromatin state and transcription in CD4 T-cell polarization.
Steven Z Josefowicz.
Immunology, 2013 Apr 18; 139(3). PMID: 23590627    Free PMC article.
Review.
T-cell tolerance in cancer.
Roza Nurieva, Junmei Wang, Anupama Sahoo.
Immunotherapy, 2013 May 04; 5(5). PMID: 23638746    Free PMC article.
Review.
Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases.
Julie Massayo Maeda Oda, Bruna Karina Banin Hirata, Roberta Losi Guembarovski, Maria Angelica Ehara Watanabe.
J Genet, 2013 May 04; 92(1). PMID: 23640423
Review.
Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers.
Taofeng Du, Yasuhiro Nagai, +2 authors, Hongtao Zhang.
Exp Mol Pathol, 2013 May 07; 95(1). PMID: 23644046    Free PMC article.
Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes.
Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi.
Front Immunol, 2013 May 16; 4. PMID: 23675373    Free PMC article.
The plasticity and stability of regulatory T cells.
Shimon Sakaguchi, Dario A A Vignali, +2 authors, Herman Waldmann.
Nat Rev Immunol, 2013 May 18; 13(6). PMID: 23681097
Highly Cited.
T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
Chaoran Li, Peter J R Ebert, Qi-Jing Li.
J Biol Chem, 2013 May 21; 288(26). PMID: 23687305    Free PMC article.
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Zhuting Hu, Weijun Zhang, Edward J Usherwood.
J Immunol, 2013 Jun 05; 191(1). PMID: 23733872    Free PMC article.
Generation and function of induced regulatory T cells.
Erica G Schmitt, Calvin B Williams.
Front Immunol, 2013 Jun 27; 4. PMID: 23801990    Free PMC article.
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
Jennifer M Monk, Tim Y Hou, +2 authors, Robert S Chapkin.
J Nutr, 2013 Jul 19; 143(9). PMID: 23864512    Free PMC article.
The role of ubiquitin ligases in the control of organ specific autoimmunity.
Gerard F Hoyne.
Am J Clin Exp Immunol, 2012 Jan 01; 1(2). PMID: 23885319    Free PMC article.
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.
Jorg van Loosdregt, Veerle Fleskens, +15 authors, Paul J Coffer.
Immunity, 2013 Aug 27; 39(2). PMID: 23973222    Free PMC article.
Highly Cited.
PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
Pin Zhang, Takashi Maruyama, +4 authors, Wanjun Chen.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977081    Free PMC article.
Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions.
Haiqi He, Bing Ni, +6 authors, Yong Zhang.
Immunology, 2013 Oct 25; 141(3). PMID: 24152290    Free PMC article.
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo.
Katherine A Smith, Rick M Maizels.
Eur J Immunol, 2013 Nov 05; 44(1). PMID: 24185641    Free PMC article.
Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging.
David C Glahn, Jack W Kent, +15 authors, John Blangero.
Proc Natl Acad Sci U S A, 2013 Nov 06; 110(47). PMID: 24191011    Free PMC article.
The plasticity of human Treg and Th17 cells and its role in autoimmunity.
Markus Kleinewietfeld, David A Hafler.
Semin Immunol, 2013 Nov 12; 25(4). PMID: 24211039    Free PMC article.
Highly Cited. Review.
Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.
Samantha L Bailey-Bucktrout, Marc Martinez-Llordella, +5 authors, Jeffrey A Bluestone.
Immunity, 2013 Nov 19; 39(5). PMID: 24238343    Free PMC article.
Highly Cited.
Nfil3-independent lineage maintenance and antiviral response of natural killer cells.
Matthew A Firth, Sharline Madera, +7 authors, Joseph C Sun.
J Exp Med, 2013 Nov 28; 210(13). PMID: 24277151    Free PMC article.
Highly Cited.
Nano polymeric carrier fabrication technologies for advanced antitumor therapy.
Wei Li, Mengxin Zhao, +8 authors, Yajun Guo.
Biomed Res Int, 2013 Dec 26; 2013. PMID: 24369011    Free PMC article.
Good guys gone bad: exTreg cells promote autoimmune arthritis.
Nicole Joller, Vijay K Kuchroo.
Nat Med, 2014 Jan 09; 20(1). PMID: 24398957
C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.
Ida Christine Norrie, Ewa Ohlsson, +2 authors, Bo T Porse.
PLoS One, 2014 Jan 10; 9(1). PMID: 24404186    Free PMC article.
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.
David A Schaer, Sadna Budhu, +8 authors, Jedd D Wolchok.
Cancer Immunol Res, 2014 Jan 15; 1(5). PMID: 24416730    Free PMC article.
Highly Cited.
Homeostatic control of regulatory T cell diversity.
Adrian Liston, Daniel H D Gray.
Nat Rev Immunol, 2014 Feb 01; 14(3). PMID: 24481337
Highly Cited. Review.
The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling.
Lisa Schreiber, Beate Pietzsch, +4 authors, Jochen Huehn.
PLoS One, 2014 Feb 08; 9(2). PMID: 24505473    Free PMC article.
The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice.
V Dioszeghy, L Mondoulet, +4 authors, P-H Benhamou.
Clin Exp Allergy, 2014 Mar 29; 44(6). PMID: 24666588    Free PMC article.
Harnessing FOXP3+ regulatory T cells for transplantation tolerance.
Herman Waldmann, Robert Hilbrands, Duncan Howie, Stephen Cobbold.
J Clin Invest, 2014 Apr 03; 124(4). PMID: 24691478    Free PMC article.
Review.
The role of T-cell receptor recognition of peptide:MHC complexes in the formation and activity of Foxp3⁺ regulatory T cells.
Katherine A Weissler, Andrew J Caton.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712456    Free PMC article.
Review.
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.
Kate S Smigiel, Shivani Srivastava, J Michael Stolley, Daniel J Campbell.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712458    Free PMC article.
Highly Cited. Review.
The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.
Xiaomei Yuan, Guoyan Cheng, Thomas R Malek.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712462    Free PMC article.
Review.
Treg functional stability and its responsiveness to the microenvironment.
Joseph Barbi, Drew Pardoll, Fan Pan.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712463    Free PMC article.
Review.
Once a Treg, always a Treg?
Deepali V Sawant, Dario A A Vignali.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712466    Free PMC article.
Highly Cited. Review.
FOXP3 and scurfy: how it all began.
Fred Ramsdell, Steven F Ziegler.
Nat Rev Immunol, 2014 Apr 12; 14(5). PMID: 24722479
Highly Cited. Review.
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells.
Aaron Arvey, Joris van der Veeken, +3 authors, Alexander Y Rudensky.
Nat Immunol, 2014 Apr 15; 15(6). PMID: 24728351    Free PMC article.
Highly Cited.
Ubiquitous points of control over regulatory T cells.
Fan Pan, Joseph Barbi.
J Mol Med (Berl), 2014 Apr 30; 92(6). PMID: 24777637    Free PMC article.
Review.
Regulatory T cells and their roles in immune dysregulation and allergy.
Laurence Pellerin, Jennifer A Jenks, +2 authors, Kari C Nadeau.
Immunol Res, 2014 May 02; 58(2-3). PMID: 24781194    Free PMC article.
Review.
Transcriptional regulatory networks for CD4 T cell differentiation.
Darah Christie, Jinfang Zhu.
Curr Top Microbiol Immunol, 2014 May 20; 381. PMID: 24839135    Free PMC article.
Review.
Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells.
Michael W Y Chan, Chia-Bin Chang, +3 authors, Shu-Fen Wu.
Mol Med, 2014 May 30; 20. PMID: 24869907    Free PMC article.
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity.
Fang-Hsuean Liao, Jr-Wen Shui, +5 authors, Ching-Yu Huang.
Cell Biosci, 2014 Jun 07; 4. PMID: 24904742    Free PMC article.
Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.
Yuning Xiong, Phyllis A Svingen, +6 authors, William A Faubion.
Am J Physiol Regul Integr Comp Physiol, 2014 Jun 20; 307(6). PMID: 24944246    Free PMC article.
Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels.
Jia-Bao Chang, Rong Xue, +4 authors, Yong-Feng Yang.
Exp Ther Med, 2014 Jun 20; 8(1). PMID: 24944616    Free PMC article.
MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
Chaoran Li, Shan Jiang, +5 authors, Qi-Jing Li.
Proc Natl Acad Sci U S A, 2014 Jun 25; 111(27). PMID: 24958888    Free PMC article.
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
Natsumi Araya, Tomoo Sato, +16 authors, Yoshihisa Yamano.
J Clin Invest, 2014 Jun 25; 124(8). PMID: 24960164    Free PMC article.
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.
Chuan Wu, Theresa Thalhamer, +7 authors, Vijay K Kuchroo.
Immunity, 2014 Jul 30; 41(2). PMID: 25065622    Free PMC article.
Highly Cited.
PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation.
Zhiyuan Li, Fang Lin, +10 authors, Bin Li.
J Biol Chem, 2014 Aug 07; 289(39). PMID: 25096571    Free PMC article.
Transcriptional and epigenetic regulation of T-helper lineage specification.
Subhash K Tripathi, Riitta Lahesmaa.
Immunol Rev, 2014 Aug 16; 261(1). PMID: 25123277    Free PMC article.
Review.
Complex interactions of transcription factors in mediating cytokine biology in T cells.
Peng Li, Rosanne Spolski, Wei Liao, Warren J Leonard.
Immunol Rev, 2014 Aug 16; 261(1). PMID: 25123282    Free PMC article.
Review.
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Xudong Li, Yuqiong Liang, +2 authors, Ye Zheng.
Cell, 2014 Aug 16; 158(4). PMID: 25126782    Free PMC article.
Highly Cited.
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.
Yongqiang Feng, Aaron Arvey, +3 authors, Alexander Y Rudensky.
Cell, 2014 Aug 16; 158(4). PMID: 25126783    Free PMC article.
Highly Cited.
Decreased percentage of CD4(+)Foxp3(+)TGF-β(+) and increased percentage of CD4(+)IL-17(+) cells in bronchoalveolar lavage of asthmatics.
Adam Barczyk, Wladyslaw Pierzchala, +4 authors, Ian M Adcock.
J Inflamm (Lond), 2014 Aug 19; 11. PMID: 25132806    Free PMC article.
Utilizing regulatory T cells against rheumatoid arthritis.
Mohammad Haque, Kristin Fino, +2 authors, Jianxun Song.
Front Oncol, 2014 Aug 26; 4. PMID: 25152867    Free PMC article.
Review.
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.
Duncan Howie, Herman Waldmann, Stephen Cobbold.
Front Immunol, 2014 Sep 16; 5. PMID: 25221554    Free PMC article.
Review.
The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant: Therapeutic Potential and Implications.
Jiemiao Hu, Jun Yan, +4 authors, Shulin Li.
Int Rev Immunol, 2016 Nov 01; 35(4). PMID: 25259408    Free PMC article.
Review.
Continuous requirement for the TCR in regulatory T cell function.
Andrew G Levine, Aaron Arvey, Wei Jin, Alexander Y Rudensky.
Nat Immunol, 2014 Sep 30; 15(11). PMID: 25263123    Free PMC article.
Highly Cited.
MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu.
Dewan M S Hossain, Abir K Panda, +7 authors, Gaurisankar Sa.
Immunology, 2014 Oct 07; 144(4). PMID: 25284464    Free PMC article.
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
Daniel Bilbao, Luisa Luciani, +2 authors, Nadia Rosenthal.
EMBO Mol Med, 2014 Oct 24; 6(11). PMID: 25339185    Free PMC article.
Constitutive activation of MEK1 promotes Treg cell instability in vivo.
Jitao Guo, Jianhua Zhang, +3 authors, Xuyu Zhou.
J Biol Chem, 2014 Nov 02; 289(51). PMID: 25361764    Free PMC article.
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Maura Rossetti, Roberto Spreafico, +7 authors, Salvatore Albani.
J Immunol, 2014 Dec 03; 194(1). PMID: 25452562    Free PMC article.
Regulatory T cells resist virus infection-induced apoptosis.
Jenny W Che, Anke R M Kraft, Liisa K Selin, Raymond M Welsh.
J Virol, 2014 Dec 05; 89(4). PMID: 25473049    Free PMC article.
Treg identity protection by an epigenetic switch.
Xudong Li, Ye Zheng.
Cell Cycle, 2014 Dec 09; 13(20). PMID: 25485491    Free PMC article.
CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells.
Ulysse Ateba-Ngoa, Ghyslain Mombo-Ngoma, +8 authors, Ayola Akim Adegnika.
PLoS One, 2014 Dec 23; 9(12). PMID: 25531674    Free PMC article.
Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.
Dean Franckaert, James Dooley, +7 authors, Susan M Schlenner.
Immunol Cell Biol, 2014 Dec 24; 93(4). PMID: 25533288    Free PMC article.
DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Yongheng Chen, Chunxia Chen, +9 authors, Lin Chen.
Nucleic Acids Res, 2015 Jan 09; 43(2). PMID: 25567984    Free PMC article.
Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing.
Zachary Chow, Ashish Banerjee, Michael J Hickey.
Immunol Cell Biol, 2015 Jan 15; 93(4). PMID: 25582339
Review.
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
Ajithkumar Vasanthakumar, Kazuyo Moro, +18 authors, Axel Kallies.
Nat Immunol, 2015 Jan 20; 16(3). PMID: 25599561
Highly Cited.
GP96 is a GARP chaperone and controls regulatory T cell functions.
Yongliang Zhang, Bill X Wu, +9 authors, Zihai Li.
J Clin Invest, 2015 Jan 22; 125(2). PMID: 25607841    Free PMC article.
Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection.
D E de Almeida Nagata, H-A Ting, +5 authors, N W Lukacs.
Mucosal Immunol, 2015 Feb 12; 8(5). PMID: 25669152    Free PMC article.
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Huey-Wen Hsiao, Tzu-Sheng Hsu, +5 authors, Ming-Zong Lai.
Nat Commun, 2015 Feb 20; 6. PMID: 25695215    Free PMC article.
The role of regulatory T cells in immune dysfunction during sepsis.
Chao Cao, Tao Ma, Yan-Fen Chai, Song-Tao Shou.
World J Emerg Med, 2015 Mar 25; 6(1). PMID: 25802559    Free PMC article.
Review.
Regulatory T cells turn pathogenic.
Jitao Guo, Xuyu Zhou.
Cell Mol Immunol, 2015 May 06; 12(5). PMID: 25942597    Free PMC article.
Review.
FGL2 as a Multimodality Regulator of Tumor-Mediated Immune Suppression and Therapeutic Target in Gliomas.
Jun Yan, Ling-Yuan Kong, +5 authors, Shulin Li.
J Natl Cancer Inst, 2015 May 15; 107(8). PMID: 25971300    Free PMC article.
Regulatory T cell identity: formation and maintenance.
Xudong Li, Ye Zheng.
Trends Immunol, 2015 May 20; 36(6). PMID: 25981968    Free PMC article.
Highly Cited. Review.
Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.
Caroline Huygens, Stéphanie Liénart, +4 authors, Sophie Lucas.
J Biol Chem, 2015 Jul 02; 290(33). PMID: 26126825    Free PMC article.
Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.
Peter T Sage, Catherine L Tan, +2 authors, Arlene H Sharpe.
Cell Rep, 2015 Jul 07; 12(2). PMID: 26146074    Free PMC article.
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
Michelle J Boyle, Prasanna Jagannathan, +21 authors, Margaret E Feeney.
PLoS Pathog, 2015 Jul 17; 11(7). PMID: 26182204    Free PMC article.
AAV2/8-humanFOXP3 gene therapy shows robust anti-atherosclerosis efficacy in LDLR-KO mice on high cholesterol diet.
M Cao, S A Theus, +4 authors, P L Hermonat.
J Transl Med, 2015 Jul 19; 13. PMID: 26187646    Free PMC article.
Inflammation-associated genes: risks and benefits to Foxp3+ regulatory T-cell function.
Richard A O'Connor, Stephen M Anderton.
Immunology, 2015 Jul 21; 146(2). PMID: 26190495    Free PMC article.
Review.
Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.
Kailash Singh, Erik Kadesjö, +6 authors, Lina Thorvaldson.
Sci Rep, 2015 Aug 01; 5. PMID: 26224624    Free PMC article.
Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes.
Jennie H M Yang, Antony J Cutler, +10 authors, Timothy I M Tree.
Diabetes, 2015 Aug 01; 64(11). PMID: 26224887    Free PMC article.
Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity.
Andrzej Chruscinski, Hassan Sadozai, +4 authors, Gary A Levy.
Rambam Maimonides Med J, 2015 Aug 05; 6(3). PMID: 26241231    Free PMC article.
Foxp3-modified bone marrow mesenchymal stem cells promotes liver allograft tolerance through the generation of regulatory T cells in rats.
Haizhi Qi, Guangshun Chen, +2 authors, Jiequn Li.
J Transl Med, 2015 Aug 22; 13. PMID: 26293578    Free PMC article.
FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases.
Jia Nie, Yang Yang Li, +2 authors, Bin Li.
Front Immunol, 2015 Oct 07; 6. PMID: 26441996    Free PMC article.
Review.
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Y Zhong, H Tang, +7 authors, X Mao.
Clin Exp Immunol, 2015 Oct 11; 183(3). PMID: 26452441    Free PMC article.
In vivo induction of regulatory T cells for immune tolerance in hemophilia.
Xiaomei Wang, Cox Terhorst, Roland W Herzog.
Cell Immunol, 2015 Oct 12; 301. PMID: 26454643    Free PMC article.
Review.
Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.
Charlotte Spitz, Holger Winkels, +4 authors, Norbert Gerdes.
Cell Mol Life Sci, 2015 Nov 01; 73(5). PMID: 26518635
Review.
TGF-β in tolerance, development and regulation of immunity.
Chris J C Johnston, Danielle J Smyth, David W Dresser, Rick M Maizels.
Cell Immunol, 2015 Dec 01; 299. PMID: 26617281    Free PMC article.
FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly.
Audrey Romano, Xunya Hou, +15 authors, Alain Dessein.
PLoS Negl Trop Dis, 2016 Jan 06; 10(1). PMID: 26731721    Free PMC article.
Unstable FoxP3+ T regulatory cells in NZW mice.
Fabien Dépis, Ho-Keun Kwon, Diane Mathis, Christophe Benoist.
Proc Natl Acad Sci U S A, 2016 Jan 16; 113(5). PMID: 26768846    Free PMC article.
Expression and significance of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood of patients with different phenotypes of Guillain-Barré syndrome.
Hao Wang, Li Li, +3 authors, Wei-Dong Qian.
Int J Clin Exp Med, 2016 Jan 16; 8(10). PMID: 26770543    Free PMC article.
Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.
Shu Liu, Xiangdong Sun, +5 authors, Xinchen Sun.
Am J Cancer Res, 2016 Jan 26; 5(11). PMID: 26807310    Free PMC article.
Review.
Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.
Maninder Sidhu-Varma, David Q Shih, Stephan R Targan.
Inflamm Bowel Dis, 2016 Jan 29; 22(3). PMID: 26818423    Free PMC article.
YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity.
Soo Seok Hwang, Sung Woong Jang, +7 authors, Gap Ryol Lee.
Nat Commun, 2016 Feb 20; 7. PMID: 26892542    Free PMC article.
(Compl)Ex-Th17-Treg cell inter-relationship.
Nataša Obermajer, Marc H Dahlke.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942054    Free PMC article.
Haploidentical Hematopoietic Stem Cell Transplantation: Expanding the Horizon for Hematologic Disorders.
Mohammad Faizan Zahid, David Alan Rizzieri.
Adv Hematol, 2016 Mar 08; 2016. PMID: 26949395    Free PMC article.
Review.
Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.
Shimin Wang, Xiang Gao, +5 authors, Carl K Edwards.
Sci Rep, 2016 Apr 15; 6. PMID: 27075020    Free PMC article.
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Liping Sun, Hao Jin, Hui Li.
Oncotarget, 2016 Apr 21; 7(27). PMID: 27095576    Free PMC article.
Review.
A pilot study showing associations between frequency of CD4(+) memory cell subsets at diagnosis and duration of partial remission in type 1 diabetes.
Rosita Moya, Hannah Kathryn Robertson, +4 authors, Joanna Davida Davies.
Clin Immunol, 2016 Apr 27; 166-167. PMID: 27114212    Free PMC article.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.
Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion.
Front Immunol, 2016 Jun 01; 7. PMID: 27242797    Free PMC article.
Review.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
Xin Li, Nicole V Acuff, +4 authors, Wendy T Watford.
J Biol Chem, 2016 Jun 05; 291(32). PMID: 27261457    Free PMC article.
Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.
Hajime Kashima, Fumiyasu Momose, +6 authors, Akira Asai.
PLoS One, 2016 Jun 11; 11(6). PMID: 27284967    Free PMC article.
TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.
Maura Rossetti, Roberto Spreafico, +11 authors, Salvatore Albani.
Ann Rheum Dis, 2016 Jun 18; 76(2). PMID: 27311837    Free PMC article.
Adenosine promotes Foxp3 expression in Treg cells in sepsis model by activating JNK/AP-1 pathway.
Rui Bao, Jiong Hou, +4 authors, Tao Yang.
Am J Transl Res, 2016 Jun 28; 8(5). PMID: 27347335    Free PMC article.
Regulatory T Cells: Differentiation and Function.
George Plitas, Alexander Y Rudensky.
Cancer Immunol Res, 2016 Sep 04; 4(9). PMID: 27590281    Free PMC article.
Highly Cited. Review.
Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells.
Shan-Shan Meng, Rong Gao, +7 authors, Jing Liu.
Respir Res, 2016 Sep 21; 17(1). PMID: 27646403    Free PMC article.
Restoring immune tolerance in neuromyelitis optica: Part II.
Amit Bar-Or, Larry Steinman, +15 authors, Michael R Yeaman.
Neurol Neuroimmunol Neuroinflamm, 2016 Sep 21; 3(5). PMID: 27648464    Free PMC article.
Review.
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Valerie A Gerriets, Rigel J Kishton, +10 authors, Jeffrey C Rathmell.
Nat Immunol, 2016 Nov 01; 17(12). PMID: 27695003    Free PMC article.
Highly Cited.
CD4+ Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T-cell suppression during chronic liver disease.
Dana Tedesco, Manoj Thapa, +7 authors, Arash Grakoui.
Hepatology, 2016 Oct 25; 65(2). PMID: 27774611    Free PMC article.
Control of inflammation by stromal Hedgehog pathway activation restrains colitis.
John J Lee, Michael E Rothenberg, +9 authors, Philip A Beachy.
Proc Natl Acad Sci U S A, 2016 Nov 07; 113(47). PMID: 27815529    Free PMC article.
Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
Alexandra Ion, Iris Maria Popa, +5 authors, Daniel Boda.
Dis Markers, 2016 Nov 09; 2016. PMID: 27821903    Free PMC article.
Review.
Functional defects in CD4+ CD25high FoxP3+ regulatory cells in ankylosing spondylitis.
Huifang Guo, Ming Zheng, +5 authors, Ping Zhu.
Sci Rep, 2016 Dec 03; 6. PMID: 27901054    Free PMC article.
Genetic and epigenetic studies of FOXP3 in asthma and allergy.
Cintia Rodrigues Marques, Ryan Santos Costa, +6 authors, Camila Alexandrina Figueiredo.
Asthma Res Pract, 2015 Oct 20; 1. PMID: 27965764    Free PMC article.
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Patrizia Fasching, Martin Stradner, +2 authors, Johannes Fessler.
Molecules, 2017 Jan 19; 22(1). PMID: 28098832    Free PMC article.
Review.
Expression of GARP Is Increased in Tumor-Infiltrating Regulatory T Cells and Is Correlated to Clinicopathology of Lung Cancer Patients.
Hao Jin, Liping Sun, +2 authors, Hui Li.
Front Immunol, 2017 Mar 07; 8. PMID: 28261204    Free PMC article.
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
David Zemmour, Alvin Pratama, +2 authors, Christophe Benoist.
Proc Natl Acad Sci U S A, 2017 Apr 12; 114(17). PMID: 28396406    Free PMC article.
Highly Cited.
Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer.
Dennis O Adeegbe, Yan Liu, +22 authors, Kwok-Kin Wong.
Cancer Discov, 2017 Apr 15; 7(8). PMID: 28408401    Free PMC article.
Highly Cited.
Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
Agata Bartczak, Jianhua Zhang, +6 authors, Gary A Levy.
World J Gastroenterol, 2017 May 11; 23(15). PMID: 28487604    Free PMC article.
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions.
David Bauché, Julien C Marie.
Clin Transl Immunology, 2017 May 20; 6(4). PMID: 28523126    Free PMC article.
Review.
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Andrew G Levine, Alejandra Mendoza, +11 authors, Alexander Y Rudensky.
Nature, 2017 Jun 14; 546(7658). PMID: 28607488    Free PMC article.
Highly Cited.
Molecular mechanisms underlying Th1-like Treg generation and function.
Alexandra Kitz, Margarita Dominguez-Villar.
Cell Mol Life Sci, 2017 Jun 19; 74(22). PMID: 28624966    Free PMC article.
Review.
Memory T Cells in Type 1 Diabetes: the Devil is in the Detail.
Aditi Narsale, Joanna D Davies.
Curr Diab Rep, 2017 Jul 04; 17(8). PMID: 28670660
Review.
Regulatory T cells in acute and chronic kidney diseases.
Rahul Sharma, Gilbert R Kinsey.
Am J Physiol Renal Physiol, 2017 Sep 08; 314(5). PMID: 28877881    Free PMC article.
Review.
Newly Characterized Murine Undifferentiated Sarcoma Models Sensitive to Virotherapy with Oncolytic HSV-1 M002.
Eric K Ring, Rong Li, +8 authors, Gregory K Friedman.
Mol Ther Oncolytics, 2017 Oct 17; 7. PMID: 29034313    Free PMC article.
Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.
Teresa Lozano, Marta Gorraiz, +9 authors, Juan José Lasarte.
Oncotarget, 2017 Oct 27; 8(42). PMID: 29069740    Free PMC article.
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production.
Fanny Polesso, Minhazur Sarker, +2 authors, Susan E Murray.
Sci Rep, 2017 Nov 09; 7(1). PMID: 29116141    Free PMC article.
Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.
Kyle L O'Hagan, Stephen D Miller, Hyewon Phee.
Sci Rep, 2017 Dec 08; 7(1). PMID: 29213081    Free PMC article.
Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
Connor J Dwyer, Allison L Bayer, +6 authors, Thomas R Malek.
Sci Signal, 2017 Dec 21; 10(510). PMID: 29259102    Free PMC article.
SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells.
Chuan Wu, Zuojia Chen, +4 authors, Vijay Kuchroo.
Cell Rep, 2018 Jan 19; 22(3). PMID: 29346764    Free PMC article.
Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy.
Tom Erkers, Arwen Stikvoort, Michael Uhlin.
Stem Cells Int, 2018 Jan 20; 2017. PMID: 29348758    Free PMC article.
Review.
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Wan-Chen Hsieh, Tzu-Sheng Hsu, Ya-Jen Chang, Ming-Zong Lai.
Nat Commun, 2018 Feb 02; 9(1). PMID: 29386580    Free PMC article.
When worlds collide: Th17 and Treg cells in cancer and autoimmunity.
Hannah M Knochelmann, Connor J Dwyer, +4 authors, Chrystal M Paulos.
Cell Mol Immunol, 2018 Mar 23; 15(5). PMID: 29563615    Free PMC article.
Highly Cited. Review.
FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.
Jianguang Du, Qun Wang, Steven F Ziegler, Baohua Zhou.
J Biol Chem, 2018 May 19; 293(26). PMID: 29773655    Free PMC article.
Tight correlation between FoxM1 and FoxP3+ Tregs in gastric cancer and their clinical significance.
Xiaoxiao Li, Kai Ma, +4 authors, Zimin Liu.
Clin Exp Med, 2018 May 29; 18(3). PMID: 29804142
Regulatory T Lymphocytes in Periodontitis: A Translational View.
Carla Alvarez, Carolina Rojas, +3 authors, Rolando Vernal.
Mediators Inflamm, 2018 May 29; 2018. PMID: 29805313    Free PMC article.
Review.
Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model.
Jiang Wu, Yan Zhong, +2 authors, Wei Cai.
Food Nutr Res, 2018 Jun 09; 62. PMID: 29881333    Free PMC article.
Study of the association of forkhead box P3 (FOXP3) gene polymorphisms with unexplained recurrent spontaneous abortions in Indian population.
Shivani Mishra, Anukool Srivastava, Kausik Mandal, Shubha R Phadke.
J Genet, 2018 Jun 23; 97(2). PMID: 29932060
MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease.
Cuilian Liu, Haoran Yang, +2 authors, Qingguo Ruan.
Immunology, 2018 Aug 23; 155(4). PMID: 30133700    Free PMC article.
Review.
Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus.
Suba Nookala, Santhosh Mukundan, +2 authors, Malak Kotb.
Infect Immun, 2018 Sep 19; 86(12). PMID: 30224551    Free PMC article.
The FOXP3 rs3761547 Gene Polymorphism in Multiple Sclerosis as a Male-Specific Risk Factor.
Natalia Wawrusiewicz-Kurylonek, Monika Chorąży, +6 authors, Alina Kułakowska.
Neuromolecular Med, 2018 Sep 20; 20(4). PMID: 30229436    Free PMC article.
The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells.
Sayantani Ghosh, Sinchita Roy-Chowdhuri, +2 authors, Dipayan Rudra.
Nat Commun, 2018 Oct 28; 9(1). PMID: 30367168    Free PMC article.
The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.
Nada Abdel Aziz, Justin Komguep Nono, Thabo Mpotje, Frank Brombacher.
PLoS Biol, 2018 Nov 01; 16(10). PMID: 30379806    Free PMC article.
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
Xiang Sun, Yu Cui, +2 authors, Xiaolong Liu.
J Exp Med, 2019 Sep 14; 216(12). PMID: 31515281    Free PMC article.
Foxp3 Instability Helps tTregs Distinguish Self and Non-self.
Zhongmei Zhang, Xuyu Zhou.
Front Immunol, 2019 Oct 15; 10. PMID: 31608056    Free PMC article.
Review.
T-Follicular Regulatory Cells: Potential Therapeutic Targets in Rheumatoid Arthritis.
Tingting Ding, Hongqing Niu, +3 authors, Caihong Wang.
Front Immunol, 2019 Dec 19; 10. PMID: 31849938    Free PMC article.
Review.
Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function.
Sung Woong Jang, Soo Seok Hwang, +7 authors, Gap Ryol Lee.
Proc Natl Acad Sci U S A, 2019 Dec 04; 116(51). PMID: 31792183    Free PMC article.
Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.
Runze Qiu, Liyu Zhou, +5 authors, Dongping Yuan.
Clin Rev Allergy Immunol, 2018 Nov 19; 58(1). PMID: 30449014
Review.
FoxP3 in Treg cell biology: a molecular and structural perspective.
G Deng, X Song, M I Greene.
Clin Exp Immunol, 2019 Aug 07; 199(3). PMID: 31386175    Free PMC article.
Review.
Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program.
Handong Zheng, Xiang Wu, +7 authors, Xuexian O Yang.
Mucosal Immunol, 2019 Nov 30; 13(2). PMID: 31780776    Free PMC article.
The Role of Fibrinogen-Like Protein 2 on Immunosuppression and Malignant Progression in Glioma.
Khatri Latha, Jun Yan, +13 authors, Ganesh Rao.
J Natl Cancer Inst, 2018 Jun 28; 111(3). PMID: 29947810    Free PMC article.
Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients.
Tom D Y Reijnders, Coen A Stegeman, +3 authors, Wayel H Abdulahad.
Sci Rep, 2019 Jun 06; 9(1). PMID: 31164680    Free PMC article.
An immunometabolic pathomechanism for chronic obstructive pulmonary disease.
Sara Bruzzaniti, Marialuisa Bocchino, +17 authors, Mario Galgani.
Proc Natl Acad Sci U S A, 2019 Jul 17; 116(31). PMID: 31308239    Free PMC article.
Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut-sensitized mice.
L Mondoulet, V Dioszeghy, +9 authors, J Tost.
Allergy, 2018 May 21; 74(1). PMID: 29779209    Free PMC article.
Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease.
Linyan Zhou, Dongyan Liu, +2 authors, Yan Li.
Gut Liver, 2019 Jan 03; 13(4). PMID: 30600673    Free PMC article.
High concentrations of atorvastatin reduce in-vitro function of conventional T and regulatory T cells.
A L Rodríguez-Perea, M Rojas, P A Velilla-Hernández.
Clin Exp Immunol, 2019 Jan 15; 196(2). PMID: 30638266    Free PMC article.
The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.
Bing Liu, Oscar C Salgado, +8 authors, Hai-Bin Ruan.
Nat Commun, 2019 Jan 22; 10(1). PMID: 30664665    Free PMC article.
Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease.
Jinfeng Yang, Abdulraouf Ramadan, +7 authors, Sophie Paczesny.
JCI Insight, 2019 Jan 30; 4(5). PMID: 30694220    Free PMC article.
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.
Shenda Hou, Rachel L Clement, +4 authors, Peter T Sage.
J Exp Med, 2019 Feb 02; 216(3). PMID: 30705058    Free PMC article.
Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression.
Nicholas Borcherding, Andrew P Voigt, +3 authors, Ali Jabbari.
Clin Cancer Res, 2019 Feb 06; 25(10). PMID: 30718356    Free PMC article.
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Garima Garg, Andreas Muschaweckh, +19 authors, Thomas Korn.
Cell Rep, 2019 Feb 14; 26(7). PMID: 30759395    Free PMC article.
Highly Cited.
The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.
Yuanming Xu, Johanna Melo-Cardenas, +9 authors, Deyu Fang.
JCI Insight, 2019 Mar 08; 4(5). PMID: 30843874    Free PMC article.
Treg programming and therapeutic reprogramming in cancer.
Mariela A Moreno Ayala, Zehui Li, Michel DuPage.
Immunology, 2019 Mar 14; 157(3). PMID: 30866047    Free PMC article.
Review.
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.
Veerle Fleskens, Carlos M Minutti, +11 authors, Paul J Coffer.
Cell Rep, 2019 Mar 28; 26(13). PMID: 30917315    Free PMC article.
Treg cells in autoimmunity: from identification to Treg-based therapies.
Lisa Göschl, Clemens Scheinecker, Michael Bonelli.
Semin Immunopathol, 2019 Apr 07; 41(3). PMID: 30953162
Review.
Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function.
Jiazi Ren, Lei Han, +8 authors, Haikun Wang.
PLoS Biol, 2019 May 28; 17(5). PMID: 31125332    Free PMC article.
Remembering to remember: T cell memory maintenance and plasticity.
Kyla D Omilusik, Ananda W Goldrath.
Curr Opin Immunol, 2019 Jun 07; 58. PMID: 31170601    Free PMC article.
Review.
Blocking inflammation to improve immunotherapy of advanced cancer.
Antonio Macciò, Clelia Madeddu.
Immunology, 2019 Dec 11; 159(4). PMID: 31821533    Free PMC article.
Review.
Transcriptional control of regulatory T cell development and function.
Chong T Luo, Ming O Li.
Trends Immunol, 2013 Sep 11; 34(11). PMID: 24016547    Free PMC article.
Review.
Regulatory T Cells and Plasmacytoid Dendritic Cells Within the Tumor Microenvironment in Gastric Cancer Are Correlated With Gastric Microbiota Dysbiosis: A Preliminary Study.
Zongxin Ling, Li Shao, +5 authors, Xiaosun Liu.
Front Immunol, 2019 Apr 03; 10. PMID: 30936882    Free PMC article.
High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer.
Minyu Wang, Yu-Kuan Huang, +14 authors, Alex Boussioutas.
Clin Transl Immunology, 2020 May 08; 9(5). PMID: 32377339    Free PMC article.
Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.
Kelly Walton, Mario R Fernandez, +18 authors, Brian C Betts.
JCI Insight, 2020 Apr 08; 5(9). PMID: 32255769    Free PMC article.
Airway Remodeling in Asthma.
Kenneth P Hough, Miranda L Curtiss, +4 authors, Victor J Thannickal.
Front Med (Lausanne), 2020 Jun 09; 7. PMID: 32509793    Free PMC article.
Review.
Reduced frequency and functional defects of CD4+CD25highCD127low/- regulatory T cells in patients with unexplained recurrent spontaneous abortion.
Li Luo, Xun Zeng, +3 authors, Shangwei Li.
Reprod Biol Endocrinol, 2020 Jun 12; 18(1). PMID: 32522204    Free PMC article.
CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Jessica T Cortez, Elena Montauti, +22 authors, Deyu Fang.
Nature, 2020 Jun 06; 582(7812). PMID: 32499641    Free PMC article.
Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells.
Mark D Mannie, Kayla B DeOca, Alexander G Bastian, Cody D Moorman.
Cell Immunol, 2020 Jul 28; 355. PMID: 32712270    Free PMC article.
Review.
Tissue regulatory T cells.
Prudence PokWai Lui, Inchul Cho, Niwa Ali.
Immunology, 2020 May 29; 161(1). PMID: 32463116    Free PMC article.
Review.
T-Regulatory Cells Confer Increased Myelination and Stem Cell Activity after Stroke-Induced White Matter Injury.
Sydney Zarriello, Elliot G Neal, Yuji Kaneko, Cesario V Borlongan.
J Clin Med, 2019 Apr 24; 8(4). PMID: 31010132    Free PMC article.
Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects.
Chang-Zhu Pei, Young Ju Kim, Kwang-Hyun Baek.
Obstet Gynecol Sci, 2019 Jul 25; 62(4). PMID: 31338338    Free PMC article.
Review.
Toxoplasma gondii excreted-secreted antigens suppress Foxp3 promoter activity via a SP1-dependent mechanism.
Jinling Chen, Jingjing Wang, +3 authors, Yinong Duan.
J Cell Mol Med, 2020 Jul 31; 24(18). PMID: 32729205    Free PMC article.
Medical Treatment Can Unintentionally Alter the Regulatory T-Cell Compartment in Patients with Widespread Pathophysiologic Conditions.
Sabrina N Copsel, Thomas R Malek, Robert B Levy.
Am J Pathol, 2020 Aug 04; 190(10). PMID: 32745461    Free PMC article.
Review.
Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf.
Massimo Claudio Fantini, Agnese Favale, Sara Onali, Federica Facciotti.
Int J Mol Sci, 2020 Sep 18; 21(18). PMID: 32937953    Free PMC article.
Review.
HIF-2α is indispensable for regulatory T cell function.
Tzu-Sheng Hsu, Yen-Lin Lin, +6 authors, Ming-Zong Lai.
Nat Commun, 2020 Oct 08; 11(1). PMID: 33024109    Free PMC article.
Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory.
Wojciech Siwek, Sahar S H Tehrani, João F Mata, Lars E T Jansen.
Mol Cell, 2020 Oct 28; 80(3). PMID: 33108759    Free PMC article.
Intron-1 rs3761548 is related to the defective transcription of Foxp3 in psoriasis through abrogating E47/c-Myb binding.
Z Shen, L Chen, +2 authors, Y Liu.
J Cell Mol Med, 2010 Apr 24; 14(1-2). PMID: 20414968    Free PMC article.
Proximal human FOXP3 promoter transactivated by NF-kappaB and negatively controlled by feedback loop and SP3.
Paul Eckerstorfer, Michael Novy, +4 authors, Hannes Stockinger.
Mol Immunol, 2010 May 14; 47(11-12). PMID: 20462637    Free PMC article.
Transcriptional regulation of CD4+ TH  cells that mediate tissue inflammation.
Tiffany T Loo, Yuanyuan Gao, Vanja Lazarevic.
J Leukoc Biol, 2018 Aug 27; 104(6). PMID: 30145844    Free PMC article.
Review.
High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response.
Noa Ziklo, Wilhelmina M Huston, Kuong Taing, Peter Timms.
BMC Infect Dis, 2019 Mar 06; 19(1). PMID: 30832593    Free PMC article.
<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.
Vitaly Kochin, Hiroyoshi Nishikawa.
Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651    Free PMC article.
Review.
Regulatory T Cell Stability and Plasticity in Atherosclerosis.
Amal J Ali, Jeffrey Makings, Klaus Ley.
Cells, 2020 Dec 17; 9(12). PMID: 33322482    Free PMC article.
Review.
Ubiquitin-Dependent Regulation of Treg Function and Plasticity.
Yi Dong, Fan Pan.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523443
Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia.
Cigdem Sahbaz, Noushin Zibandey, +6 authors, Tunc Akkoc.
Psychopharmacology (Berl), 2020 Mar 30; 237(6). PMID: 32221694
Regulatory T cells in autoimmune disease.
Margarita Dominguez-Villar, David A Hafler.
Nat Immunol, 2018 Jun 22; 19(7). PMID: 29925983    Free PMC article.
Highly Cited. Review.
The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial.
Zeinab Ghorbani, Pegah Rafiee, +5 authors, Mansoureh Togha.
J Pharm Health Care Sci, 2021 Mar 04; 7(1). PMID: 33653409    Free PMC article.
Searching for Peptide Inhibitors of T Regulatory Cell Activity by Targeting Specific Domains of FOXP3 Transcription Factor.
Teresa Lozano, Noelia Casares, +8 authors, Juan José Lasarte.
Biomedicines, 2021 Mar 07; 9(2). PMID: 33671179    Free PMC article.
Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming.
Allison E Norlander, Melissa H Bloodworth, +16 authors, R Stokes Peebles.
J Clin Invest, 2021 Feb 03; 131(7). PMID: 33529171    Free PMC article.
Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy.
Cody D Moorman, Sue J Sohn, Hyewon Phee.
Front Immunol, 2021 Apr 16; 12. PMID: 33854514    Free PMC article.
Review.
The role of Fibrinogen-like proteins in Cancer.
Jing Yu, Jing Li, +8 authors, Yueshui Zhao.
Int J Biol Sci, 2021 Apr 20; 17(4). PMID: 33867830    Free PMC article.
Review.
FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis.
Concetta Scazzone, Luisa Agnello, +9 authors, Marcello Ciaccio.
Brain Sci, 2021 Apr 04; 11(4). PMID: 33806248    Free PMC article.
Ex-TFRs: A Missing Piece of the SLE Puzzle?
Xundong Wei, Jianhua Zhang, Xuyu Zhou.
Front Immunol, 2021 Apr 27; 12. PMID: 33897710    Free PMC article.
Review.
Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19.
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Patterns (N Y), 2021 Apr 13; 2(5). PMID: 33842903    Free PMC article.
Clinicopathological analysis of hepatic immune-related adverse events in comparison with autoimmune hepatitis and graft-versus host disease.
Satoru Hagiwara, Tomohiro Watanabe, +15 authors, Naoshi Nishida.
Sci Rep, 2021 May 01; 11(1). PMID: 33927311    Free PMC article.
Analysis of therapeutic potential of preclinical models based on DR3/TL1A pathway modulation (Review).
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Exp Ther Med, 2021 May 15; 22(1). PMID: 33986858    Free PMC article.
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Improving the Efficacy of Regulatory T Cell Therapy.
Paulien Baeten, Lauren Van Zeebroeck, +2 authors, Bieke Broux.
Clin Rev Allergy Immunol, 2021 Jul 06; 62(2). PMID: 34224053    Free PMC article.
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Insights into the biology and therapeutic implications of TNF and regulatory T cells.
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Nat Rev Rheumatol, 2021 Jul 07; 17(8). PMID: 34226727
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Th17/Treg-Related Intracellular Signaling in Patients with Chronic Obstructive Pulmonary Disease: Comparison between Local and Systemic Responses.
Juliana D Lourenço, Walcy R Teodoro, +12 authors, Fernanda D T Q S Lopes.
Cells, 2021 Jul 03; 10(7). PMID: 34206428    Free PMC article.
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.
Stanislav Dikiy, Jun Li, +10 authors, Yongqiang Feng.
Immunity, 2021 Apr 11; 54(5). PMID: 33838102    Free PMC article.
Lineage Reprogramming of Effector Regulatory T Cells in Cancer.
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Front Immunol, 2021 Aug 17; 12. PMID: 34394124    Free PMC article.
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PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Alessandro Poli, Shidqiyyah Abdul-Hamid, +7 authors, Nullin Divecha.
Proc Natl Acad Sci U S A, 2021 Jul 28; 118(31). PMID: 34312224    Free PMC article.
Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle.
Aikaterini Hatzioannou, Athina Boumpas, +4 authors, Panayotis Verginis.
Front Immunol, 2021 Sep 21; 12. PMID: 34539668    Free PMC article.
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TGF-β-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model.
Jingrong Chen, Feng Huang, +7 authors, Song Guo Zheng.
Cell Mol Immunol, 2021 Sep 25; 18(11). PMID: 34556822    Free PMC article.
Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture.
Qiang Shan, Xiang Li, +5 authors, Hai-Hui Xue.
Nat Commun, 2021 Oct 08; 12(1). PMID: 34615872    Free PMC article.
Immunology and Immune Checkpoint Inhibition in Ovarian Cancer - Current Aspects.
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Geburtshilfe Frauenheilkd, 2021 Oct 12; 81(10). PMID: 34629492    Free PMC article.
Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells.
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Front Immunol, 2021 Oct 26; 12. PMID: 34691057    Free PMC article.
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Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry.
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Mucosal Immunol, 2021 Dec 01; 15(3). PMID: 34845322    Free PMC article.
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Deciphering DNA Methylation in HIV Infection.
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Front Immunol, 2021 Dec 21; 12. PMID: 34925380    Free PMC article.
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Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence.
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Front Immunol, 2022 Jan 25; 12. PMID: 35069590    Free PMC article.
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Immunologic Parameters for Disease Activity in Rheumatoid Arthritis.
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FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis.
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TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
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Cell Rep, 2020 Apr 09; 31(1). PMID: 32268093    Free PMC article.
Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation.
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Front Immunol, 2022 Mar 22; 13. PMID: 35309306    Free PMC article.
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Front Immunol, 2022 Apr 15; 13. PMID: 35418975    Free PMC article.
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Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer.
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J Immunother Cancer, 2022 Apr 08; 10(4). PMID: 35387780    Free PMC article.