Journal Article
. 2007 Jan; 50(2):266-73.
doi: 10.1111/j.1365-2559.2006.02581.x.

A randomized controlled trial of the diagnostic accuracy of internet-based telepathology compared with conventional microscopy

P Furness 1 
Affiliations
  • PMID: 17222256
  •     16 citations

Abstract

Aims: To compare the diagnostic accuracy of internet-based virtual microscopy with conventional light microscopy, in the context of renal biopsies assessed by participants in the UK National Renal Pathology External Quality Assessment (EQA) Scheme.

Methods And Results: 'Virtual slides' of current EQA cases were made available over the internet to participants in the scheme. The approach permitted what may reasonably be described as a randomized controlled trial of the diagnostic accuracy of this mode of telepathology, in the context of renal pathology. No significant difference in diagnostic accuracy could be detected between the diagnoses proffered on the basis of virtual slides and conventional slides; but using virtual slides took pathologists considerably longer.

Conclusions: This result provides some encouragement for the implementation of such virtual slide-based telepathology systems. However, in failing to detect a difference, equivalence of diagnostic accuracy has not been proved; nor has the relevance of this result to other fields of histopathology been demonstrated. A decision to implement a diagnostic telepathology system requires consideration of numerous factors beyond diagnostic accuracy, including financial, legal, professional and ethical issues.

[Cytology in the internet].
K Glatz, L Bubendorf, D Glatz.
Pathologe, 2007 Jul 17; 28(5). PMID: 17632721
The application of JPEG2000 in virtual microscopy.
Vilppu J Tuominen, Jorma Isola.
J Digit Imaging, 2007 Nov 14; 22(3). PMID: 17999112    Free PMC article.
A European network for virtual microscopy--design, implementation and evaluation of performance.
Mikael Lundin, Janusz Szymas, +11 authors, Johan Lundin.
Virchows Arch, 2009 Mar 13; 454(4). PMID: 19280223
Cytologic evaluation of image-guided fine needle aspiration biopsies via robotic microscopy: A validation study.
Guoping Cai, Lisa A Teot, +4 authors, Anil V Parwani.
J Pathol Inform, 2010 Sep 02; 1. PMID: 20805959    Free PMC article.
Quantitative image analysis in the assessment of diffuse large B-cell lymphoma.
Devon S Chabot-Richards, David R Martin, +2 authors, Kristin E Hunt.
Mod Pathol, 2011 Aug 16; 24(12). PMID: 21841768    Free PMC article.
Review of the current state of whole slide imaging in pathology.
Liron Pantanowitz, Paul N Valenstein, +5 authors, Terence J Colgan.
J Pathol Inform, 2011 Sep 03; 2. PMID: 21886892    Free PMC article.
Highly Cited.
Improving international research with clinical specimens: 5 achievable objectives.
Joshua LaBaer.
J Proteome Res, 2012 Sep 25; 11(12). PMID: 22998582    Free PMC article.
A study assessing the feasibility and diagnostic accuracy of real-time teledermatopathology.
Elisabeth Riedl, Masoud Asgari, +2 authors, Geoffrey J Gottlieb.
Dermatol Pract Concept, 2012 Apr 01; 2(2). PMID: 23785590    Free PMC article.
Whole slide images for primary diagnostics of urinary system pathology: a feasibility study.
Shaimaa Al-Janabi, André Huisman, +3 authors, Paul J van Diest.
J Renal Inj Prev, 2015 Jan 23; 3(4). PMID: 25610886    Free PMC article.
Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes.
Cynthia C Nast, Kevin V Lemley, +4 authors, Laura Barisoni.
Semin Nephrol, 2015 Jul 29; 35(3). PMID: 26215864    Free PMC article.
Review.
Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology.
Laura Barisoni, Charlotte Gimpel, +8 authors, Stephen M Hewitt.
Clin Kidney J, 2017 Jun 07; 10(2). PMID: 28584625    Free PMC article.
Digital pathology in nephrology clinical trials, research, and pathology practice.
Laura Barisoni, Jeffrey B Hodgin.
Curr Opin Nephrol Hypertens, 2017 Sep 01; 26(6). PMID: 28858910    Free PMC article.
Review.
Reproducibility and Feasibility of Strategies for Morphologic Assessment of Renal Biopsies Using the Nephrotic Syndrome Study Network Digital Pathology Scoring System.
Jarcy Zee, Jeffrey B Hodgin, +8 authors, Laura Barisoni.
Arch Pathol Lab Med, 2018 Feb 20; 142(5). PMID: 29457738    Free PMC article.
Clinical Application of a Real-Time Telepathology System for Frozen Section Diagnosis in Comparison With Optical Microscope.
Yu Ting Huang, Salvatore Lorenzo Renne, +5 authors, Luca Di Tommaso.
Front Med (Lausanne), 2019 Oct 23; 6. PMID: 31637244    Free PMC article.
Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center.
Liron Pantanowitz, John H Sinard, +8 authors, College of American Pathologists Pathology and Laboratory Quality Center.
Arch Pathol Lab Med, 2013 May 03; 137(12). PMID: 23634907    Free PMC article.
Highly Cited. Review.
Application of telepathology for neuropathologic intraoperative consultations.
Craig Horbinski, Ronald L Hamilton.
Brain Pathol, 2009 Mar 18; 19(2). PMID: 19290998    Free PMC article.