Review
. 2007 Feb; 8(3):239-45.
doi: 10.1038/ni1443.

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

Arlene H Sharpe 1 E John Wherry  Rafi Ahmed  Gordon J Freeman  
Affiliations
  • PMID: 17304234
  •     613 citations

Abstract

The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.

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Hepatology, 2011 Apr 20; 54(1). PMID: 21503939    Free PMC article.
Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.
Joseph A Conrad, Ramesh K Ramalingam, +7 authors, Spyros A Kalams.
J Immunol, 2011 May 13; 186(12). PMID: 21562156    Free PMC article.
T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection.
Sultan Tousif, Yogesh Singh, +3 authors, Gobardhan Das.
PLoS One, 2011 May 19; 6(5). PMID: 21589883    Free PMC article.
Cancer immunotherapy: Progress and challenges in the clinical setting.
Hassane M Zarour, Soldano Ferrone.
Eur J Immunol, 2011 May 28; 41(6). PMID: 21618503    Free PMC article.
Review.
Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
Tao Shen, Jiajia Zheng, +5 authors, Fengmin Lu.
Virol J, 2011 Jun 08; 8. PMID: 21645420    Free PMC article.
Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice.
Jian-Ming Li, Lauren Southerland, +6 authors, Edmund K Waller.
J Immunol, 2011 Jun 17; 187(2). PMID: 21677142    Free PMC article.
The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo.
Alison M Paterson, Keturah E Brown, +7 authors, Arlene H Sharpe.
J Immunol, 2011 Jun 24; 187(3). PMID: 21697456    Free PMC article.
CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease.
Marius Strioga, Vita Pasukoniene, Dainius Characiejus.
Immunology, 2011 Jun 30; 134(1). PMID: 21711350    Free PMC article.
Highly Cited. Review.
Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke.
Xuefang Ren, Kozaburo Akiyoshi, +2 authors, Halina Offner.
Stroke, 2011 Jul 09; 42(9). PMID: 21737801    Free PMC article.
PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells.
Katarzyna Karwacz, Christopher Bricogne, +4 authors, David Escors.
EMBO Mol Med, 2011 Jul 09; 3(10). PMID: 21739608    Free PMC article.
4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.
Vaiva Vezys, Pablo Penaloza-MacMaster, +5 authors, Rafi Ahmed.
J Immunol, 2011 Jul 12; 187(4). PMID: 21742975    Free PMC article.
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.
Kathryn W Juchem, Britt E Anderson, +6 authors, Mark J Shlomchik.
Blood, 2011 Jul 20; 118(23). PMID: 21768295    Free PMC article.
Longitudinal analysis of the human T cell response during acute hantavirus infection.
Therese Lindgren, Clas Ahlm, +3 authors, Niklas K Björkström.
J Virol, 2011 Jul 29; 85(19). PMID: 21795350    Free PMC article.
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Young-June Kim, Su-Jung Park, Hal E Broxmeyer.
J Immunol, 2011 Jul 29; 187(5). PMID: 21795591    Free PMC article.
HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells.
Karuppiah Muthumani, Devon J Shedlock, +10 authors, David B Weiner.
J Immunol, 2011 Aug 23; 187(6). PMID: 21856939    Free PMC article.
Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.
Gennadiy Zelinskyy, Lara Myers, +8 authors, Ulf Dittmer.
J Immunol, 2011 Aug 30; 187(7). PMID: 21873525    Free PMC article.
T cell costimulation and coinhibition: genetics and disease.
Lisa Scandiuzzi, Kaya Ghosh, Xingxing Zang.
Discov Med, 2011 Sep 01; 12(63). PMID: 21878189    Free PMC article.
Review.
The role of dendritic cells in viral persistence.
Cherie T Ng, Brian M Sullivan, Michael B A Oldstone.
Curr Opin Virol, 2011 Sep 13; 1(3). PMID: 21909344    Free PMC article.
Review.
Intracellular events and cell fate in filovirus infection.
Judith Olejnik, Elena Ryabchikova, Ronald B Corley, Elke Mühlberger.
Viruses, 2011 Sep 20; 3(8). PMID: 21927676    Free PMC article.
Review.
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Ben Youngblood, Kenneth J Oestreich, +9 authors, Rafi Ahmed.
Immunity, 2011 Sep 29; 35(3). PMID: 21943489    Free PMC article.
Highly Cited.
Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases.
Kelly Olino, Satoshi Wada, +10 authors, Kiyoshi Yoshimura.
Ann Surg Oncol, 2011 Oct 08; 19 Suppl 3. PMID: 21979110    Free PMC article.
Distinct strategies are required to suppress antigen-specific responses to genetically modified keratinocytes and fibroblasts.
Soosan Ghazizadeh, Li T Huang, Weibing Zhang.
Mol Ther, 2011 Oct 13; 20(1). PMID: 21988876    Free PMC article.
The expression of PD-1 ligands and their involvement in regulation of T cell functions in acute and chronic woodchuck hepatitis virus infection.
Ejuan Zhang, Xiaoyong Zhang, +9 authors, Mengji Lu.
PLoS One, 2011 Oct 25; 6(10). PMID: 22022563    Free PMC article.
Interleukin-10 is expressed in HepG2.2.15 cells and regulated by STAT1 pathway.
Min Liu, Youhua Hao, +2 authors, Mengji Lu.
J Huazhong Univ Sci Technolog Med Sci, 2011 Nov 01; 31(5). PMID: 22038351
Up-regulation of Tim-3 expression contributes to development of burn-induced T cell immune suppression in mice.
Zhaohui Tang, Yan Yu, +2 authors, Xiangping Yang.
J Huazhong Univ Sci Technolog Med Sci, 2011 Nov 01; 31(5). PMID: 22038354
Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer.
Sahil Adriouch, Emilie Franck, +4 authors, Olivier Boyer.
Front Microbiol, 2011 Nov 03; 2. PMID: 22046170    Free PMC article.
Ontogeny of the immune response in the ovine lung.
Fatoumata B Sow, Jack M Gallup, +2 authors, Mark R Ackermann.
Immunol Invest, 2011 Nov 30; 41(3). PMID: 22122502    Free PMC article.
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.
Noah S Butler, Jacqueline Moebius, +6 authors, John T Harty.
Nat Immunol, 2011 Dec 14; 13(2). PMID: 22157630    Free PMC article.
Highly Cited.
Immune correlates of herpes zoster in HIV-infected children and youth.
Adriana Weinberg, Sharon Huang, +5 authors, Myron J Levin.
J Virol, 2011 Dec 16; 86(5). PMID: 22171274    Free PMC article.
Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade.
Sian M Henson, Richard Macaulay, Ornella Franzese, Arne N Akbar.
Immunology, 2012 Jan 04; 135(4). PMID: 22211948    Free PMC article.
The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis.
Ricardo F Antunes, Juan Carlos Kaski, Ingrid E Dumitriu.
J Biomed Biotechnol, 2012 Jan 12; 2012. PMID: 22235167    Free PMC article.
Review.
Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors.
Vilma Decman, Brian J Laidlaw, +4 authors, E John Wherry.
J Immunol, 2012 Jan 17; 188(4). PMID: 22246631    Free PMC article.
An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells.
Andrew Stamm, Laura Valentine, Rashaun Potts, Mary Premenko-Lanier.
Virology, 2012 Feb 07; 425(2). PMID: 22305620    Free PMC article.
Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab.
D Bedoret, A K Singh, +6 authors, D T Umetsu.
Mucosal Immunol, 2012 Feb 10; 5(3). PMID: 22318492    Free PMC article.
The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.
Julius Clemence R Hafalla, Carla Claser, +4 authors, Eleanor M Riley.
PLoS Pathog, 2012 Feb 10; 8(2). PMID: 22319445    Free PMC article.
A potent vaccination strategy that circumvents lymphodepletion for effective antitumor adoptive T-cell therapy.
Hyun-Il Cho, Eduardo Reyes-Vargas, Julio C Delgado, Esteban Celis.
Cancer Res, 2012 Mar 01; 72(8). PMID: 22367213    Free PMC article.
Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis.
Bon-A Cho, Ji Hyun Sim, +10 authors, Hang-Rae Kim.
J Clin Immunol, 2012 Mar 01; 32(4). PMID: 22367266
Increased B7-H1 expression on peripheral blood T cells in oral lichen planus correlated with disease severity.
Gang Zhou, Jing Zhang, +3 authors, Xue-yi Xu.
J Clin Immunol, 2012 Mar 21; 32(4). PMID: 22430646
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation.
André Ballesteros-Tato, Beatriz León, +4 authors, Troy D Randall.
Immunity, 2012 Apr 03; 36(5). PMID: 22464171    Free PMC article.
Highly Cited.
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Kerry A Casey, Kathryn A Fraser, +9 authors, David Masopust.
J Immunol, 2012 Apr 17; 188(10). PMID: 22504644    Free PMC article.
Highly Cited.
PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques.
Ravi Dyavar Shetty, Vijayakumar Velu, +4 authors, Rama Rao Amara.
J Clin Invest, 2012 Apr 24; 122(5). PMID: 22523065    Free PMC article.
Highly Cited.
Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia.
Maciej Grzywnowicz, Joanna Zaleska, +7 authors, Krzysztof Giannopoulos.
PLoS One, 2012 Apr 26; 7(4). PMID: 22532845    Free PMC article.
Positive and negative regulation of cellular immune responses in physiologic conditions and diseases.
S Viganò, M Perreau, G Pantaleo, A Harari.
Clin Dev Immunol, 2012 May 02; 2012. PMID: 22548114    Free PMC article.
Review.
Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
Lucile Garidou, Sara Heydari, Selamawit Gossa, Dorian B McGavern.
J Virol, 2012 May 04; 86(13). PMID: 22553324    Free PMC article.
The ambiguity in immunology.
Vincenzo Barnaba, Marino Paroli, Silvia Piconese.
Front Immunol, 2012 May 09; 3. PMID: 22566903    Free PMC article.
Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells.
Edwin J Vazquez-Cintron, Ngozi R Monu, +6 authors, Alan B Frey.
PLoS One, 2012 May 09; 7(5). PMID: 22567129    Free PMC article.
PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines.
Bingbing Dai, Liang Xiao, +2 authors, Pin Wang.
Mol Ther, 2012 May 17; 20(9). PMID: 22588271    Free PMC article.
Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo.
Janine Gotot, Catherine Gottschalk, +4 authors, Isis Ludwig-Portugall.
Proc Natl Acad Sci U S A, 2012 Jun 13; 109(26). PMID: 22689978    Free PMC article.
Innate IFN-γ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.
Jared H Rowe, James M Ertelt, Sing Sing Way.
J Immunol, 2012 Jun 20; 189(2). PMID: 22711893    Free PMC article.
ICOS, SLAM and PD-1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV-related illness with pulmonary tuberculosis.
Javier Oscar Jurado, Virginia Pasquinelli, +8 authors, María Florencia Quiroga.
J Int AIDS Soc, 2012 Jun 21; 15(2). PMID: 22713261    Free PMC article.
CD28 family and chronic rejection: "to belatacept...And beyond!".
Marcos V Silva, Juliana R Machado, +3 authors, Rosana R M Corrêa.
J Transplant, 2012 Jun 22; 2012. PMID: 22720132    Free PMC article.
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Cristina Penaranda, Wilson Kuswanto, +6 authors, Hans Dooms.
Proc Natl Acad Sci U S A, 2012 Jun 27; 109(31). PMID: 22733744    Free PMC article.
Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection.
Debora Franceschini, Paola Del Porto, +10 authors, Vincenzo Barnaba.
PLoS Pathog, 2012 Jun 28; 8(6). PMID: 22737070    Free PMC article.
Deciphering the transcriptional network of the dendritic cell lineage.
Jennifer C Miller, Brian D Brown, +18 authors, Immunological Genome Consortium.
Nat Immunol, 2012 Jul 17; 13(9). PMID: 22797772    Free PMC article.
Highly Cited.
Coinhibitory molecules in autoimmune diseases.
Norihiko Watanabe, Hiroshi Nakajima.
Clin Dev Immunol, 2012 Sep 22; 2012. PMID: 22997525    Free PMC article.
Review.
Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-γ producing T cells.
Amar Singh, Aparajita Ballave Dey, +2 authors, Dipendra Kumar Mitra.
PLoS One, 2012 Oct 03; 7(9). PMID: 23028594    Free PMC article.
Transcriptomic responses to salinity stress in the Pacific oyster Crassostrea gigas.
Xuelin Zhao, Hong Yu, Lingfeng Kong, Qi Li.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029449    Free PMC article.
Cytotoxic activity of dendritic cells as a possible mechanism of negative regulation of T lymphocytes in pulmonary tuberculosis.
Ludmila V Sakhno, Marina A Tikhonova, +6 authors, Elena R Chernykh.
Clin Dev Immunol, 2012 Oct 12; 2012. PMID: 23056139    Free PMC article.
On the role of CD8 T cells in the control of persistent infections.
Sean P Stromberg, Rustom Antia.
Biophys J, 2012 Oct 23; 103(8). PMID: 23083724    Free PMC article.
The DC-HIL ligand syndecan-4 is a negative regulator of T-cell allo-reactivity responsible for graft-versus-host disease.
Jin-Sung Chung, Mizuki Tomihari, +3 authors, Kiyoshi Ariizumi.
Immunology, 2012 Nov 02; 138(2). PMID: 23113638    Free PMC article.
Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions.
Yueqin Qiu, Jianbo Chen, +15 authors, Zheng W Chen.
PLoS Pathog, 2012 Nov 13; 8(11). PMID: 23144609    Free PMC article.
Immunology beats cancer: a blueprint for successful translation.
Drew M Pardoll.
Nat Immunol, 2012 Nov 20; 13(12). PMID: 23160205    Free PMC article.
A novel hypothesis: regulatory B lymphocytes shape outcome from experimental stroke.
Halina Offner, Patricia D Hurn.
Transl Stroke Res, 2012 Nov 24; 3(3). PMID: 23175646    Free PMC article.
Functional avidity: a measure to predict the efficacy of effector T cells?
Selena Viganò, Daniel T Utzschneider, +3 authors, Alexandre Harari.
Clin Dev Immunol, 2012 Dec 12; 2012. PMID: 23227083    Free PMC article.
Review.
Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases.
Michela Flego, Alessandro Ascione, Maurizio Cianfriglia, Stefano Vella.
BMC Med, 2013 Jan 08; 11. PMID: 23289632    Free PMC article.
Review.
Regulatory B cells in autoimmune diseases.
Min Yang, Ke Rui, Shengjun Wang, Liwei Lu.
Cell Mol Immunol, 2013 Jan 08; 10(2). PMID: 23292280    Free PMC article.
Highly Cited. Review.
Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients.
Jian-Ming Li, Mohammad S Hossain, Lauren Southerland, Edmund K Waller.
Blood, 2013 Jan 18; 121(12). PMID: 23325838    Free PMC article.
Neutralizing tumor-promoting chronic inflammation: a magic bullet?
Lisa M Coussens, Laurence Zitvogel, A Karolina Palucka.
Science, 2013 Jan 19; 339(6117). PMID: 23329041    Free PMC article.
Highly Cited. Review.
T-cell memory differentiation: insights from transcriptional signatures and epigenetics.
Ben Youngblood, J Scott Hale, Rafi Ahmed.
Immunology, 2013 Jan 26; 139(3). PMID: 23347146    Free PMC article.
Highly Cited. Review.
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
Richard S Hotchkiss, Guillaume Monneret, Didier Payen.
Lancet Infect Dis, 2013 Feb 23; 13(3). PMID: 23427891    Free PMC article.
Highly Cited. Review.
Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection.
Miranda Z Smith, Sonia Bastidas, Urs Karrer, Annette Oxenius.
BMC Infect Dis, 2013 Feb 28; 13. PMID: 23442890    Free PMC article.
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
Brian R Rosborough, Dàlia Raïch-Regué, +7 authors, Angus W Thomson.
Blood, 2013 Feb 28; 121(18). PMID: 23444404    Free PMC article.
The nature of activatory and tolerogenic dendritic cell-derived signal II.
Ghaith Bakdash, Simone P Sittig, +2 authors, I Jolanda M de Vries.
Front Immunol, 2013 Mar 02; 4. PMID: 23450201    Free PMC article.
Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.
Zhirong Mou, Helen M Muleme, +5 authors, Jude E Uzonna.
J Immunol, 2013 Mar 06; 190(7). PMID: 23460745    Free PMC article.
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis.
Bernd H Zinselmeyer, Sara Heydari, +7 authors, Dorian B McGavern.
J Exp Med, 2013 Mar 27; 210(4). PMID: 23530125    Free PMC article.
Highly Cited.
Strategies to reverse melanoma-induced T-cell dysfunction.
Julien Fourcade, Hassane M Zarour.
Clin Dermatol, 2013 Apr 24; 31(3). PMID: 23608444    Free PMC article.
PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice.
Jingying Zhou, Allen K L Cheung, +8 authors, Zhiwei Chen.
J Clin Invest, 2013 May 03; 123(6). PMID: 23635778    Free PMC article.
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.
Daniel T Utzschneider, Amandine Legat, +4 authors, Dietmar Zehn.
Nat Immunol, 2013 May 07; 14(6). PMID: 23644506
Highly Cited.
Programmed death 1 lives up to its reputation in active tuberculosis.
Suraj B Sable.
J Infect Dis, 2013 May 11; 208(4). PMID: 23661796    Free PMC article.
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis.
Katherine C Chang, Carey-Ann Burnham, +7 authors, Richard S Hotchkiss.
Crit Care, 2013 May 15; 17(3). PMID: 23663657    Free PMC article.
Highly Cited.
Human iPS cell-derived hematopoietic progenitor cells induce T-cell anergy in in vitro-generated alloreactive CD8(+) T cells.
Eun-Mi Kim, Gohar Manzar, Nicholas Zavazava.
Blood, 2013 May 21; 121(26). PMID: 23687092    Free PMC article.
A randomized, double-blind, placebo-controlled assessment of BMS-936558, a fully human monoclonal antibody to programmed death-1 (PD-1), in patients with chronic hepatitis C virus infection.
David Gardiner, Jay Lalezari, +15 authors, Israel Lowy.
PLoS One, 2013 May 30; 8(5). PMID: 23717490    Free PMC article.
Highly Cited.
VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice.
Jian-Ming Li, Kasia A Darlak, +5 authors, Edmund K Waller.
PLoS One, 2013 Jun 01; 8(5). PMID: 23723978    Free PMC article.
Networking at the level of host immunity: immune cell interactions during persistent viral infections.
Cherie T Ng, Laura M Snell, David G Brooks, Michael B A Oldstone.
Cell Host Microbe, 2013 Jun 19; 13(6). PMID: 23768490    Free PMC article.
Review.
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
Ben Youngblood, Alessandra Noto, +14 authors, Daniel E Kaufmann.
J Immunol, 2013 Jun 19; 191(2). PMID: 23772031    Free PMC article.
Highly Cited.
The heart of the matter: protection of the myocardium from T cells.
Andrew H Lichtman.
J Autoimmun, 2013 Jul 03; 45. PMID: 23810579    Free PMC article.
Review.
Programmed death-1 (PD-1)-dependent functional impairment of CD4(+) T cells in recurrent genital papilloma.
Dong-Yeop Chang, Sang Hoon Song, +5 authors, Eui-Cheol Shin.
Clin Exp Med, 2013 Jul 05; 14(3). PMID: 23824147
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.
Christopher J Nirschl, Charles G Drake.
Clin Cancer Res, 2013 Jul 23; 19(18). PMID: 23868869    Free PMC article.
Highly Cited. Review.
Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils.
Lauren A Licata, Cang T Nguyen, +6 authors, Steven C Katz.
J Leukoc Biol, 2013 Jul 26; 94(4). PMID: 23883516    Free PMC article.
Dendritic-cell-based therapeutic cancer vaccines.
Karolina Palucka, Jacques Banchereau.
Immunity, 2013 Jul 31; 39(1). PMID: 23890062    Free PMC article.
Highly Cited. Review.
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.
Kendra N Iskander, Marcin F Osuchowski, +4 authors, Daniel G Remick.
Physiol Rev, 2013 Aug 01; 93(3). PMID: 23899564    Free PMC article.
Highly Cited.
T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection.
Manohar B Mutnal, Scott J Schachtele, Shuxian Hu, James R Lokensgard.
J Neuroinflammation, 2013 Aug 02; 10. PMID: 23902750    Free PMC article.
Wnt signaling inhibits CTL memory programming.
Zhengguo Xiao, Zhifeng Sun, Kendra Smyth, Lei Li.
Mol Immunol, 2013 Aug 06; 56(4). PMID: 23911398    Free PMC article.
A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.
Cornelia Schuster, Helen Brosi, +2 authors, Reinhold Schirmbeck.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977133    Free PMC article.
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
Sheetal Bodhankar, Yingxin Chen, +2 authors, Halina Offner.
J Neuroinflammation, 2013 Sep 11; 10. PMID: 24015822    Free PMC article.
The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?
Jonathan S Boomer, Jonathan M Green, Richard S Hotchkiss.
Virulence, 2013 Sep 27; 5(1). PMID: 24067565    Free PMC article.
Highly Cited. Review.
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.
Esra A Akbay, Shohei Koyama, +24 authors, Kwok-Kin Wong.
Cancer Discov, 2013 Oct 01; 3(12). PMID: 24078774    Free PMC article.
Highly Cited.
Age-dependent changes in the expression of regulatory cell surface ligands in activated human T-cells.
David H Canaday, Karen E Parker, +3 authors, Christopher J Burant.
BMC Immunol, 2013 Oct 03; 14. PMID: 24083425    Free PMC article.
PD-1 modulates steady-state and infection-induced IL-10 production in vivo.
Cortez McBerry, Alexandra Dias, +5 authors, Julio Aliberti.
Eur J Immunol, 2013 Oct 30; 44(2). PMID: 24165808    Free PMC article.
Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants.
Seleeke Flingai, Matias Czerwonko, +3 authors, David B Weiner.
Front Immunol, 2013 Nov 10; 4. PMID: 24204366    Free PMC article.
Review.
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.
Praveen K Amancha, Jung Joo Hong, +2 authors, Francois Villinger.
J Immunol, 2013 Nov 15; 191(12). PMID: 24227774    Free PMC article.
Dendritic cells, inflammation, and breast cancer.
Karolina Palucka, Lisa M Coussens, Joyce O'Shaughnessy.
Cancer J, 2013 Nov 26; 19(6). PMID: 24270350    Free PMC article.
Review.
Neuroinflammation and brain functional disconnection in Alzheimer's disease.
Francesca Baglio, Marina Saresella, +7 authors, Mario Clerici.
Front Aging Neurosci, 2013 Dec 11; 5. PMID: 24324435    Free PMC article.
Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice.
Lijun Xiao, Dimin Wang, +4 authors, Ling Chen.
Hum Vaccin Immunother, 2013 Dec 12; 10(3). PMID: 24326266    Free PMC article.
T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.
Kiera L Clayton, Matthew S Haaland, +4 authors, Mario A Ostrowski.
J Immunol, 2013 Dec 18; 192(2). PMID: 24337741    Free PMC article.
From single nucleotide polymorphisms to constant immunosuppression: mesenchymal stem cell therapy for autoimmune diseases.
Raghavan Chinnadurai, Edmund K Waller, Jacques Galipeau, Ajay K Nooka.
Biomed Res Int, 2013 Dec 19; 2013. PMID: 24350294    Free PMC article.
Review.
TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma japonicum infection.
Yanan Gao, Lin Chen, +4 authors, Guanling Wu.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376539    Free PMC article.
Identification of B7-H1 as a novel mediator of the innate immune/proinflammatory response as well as a possible myeloid cell prognostic biomarker in sepsis.
Xin Huang, Yaping Chen, +4 authors, Alfred Ayala.
J Immunol, 2014 Jan 01; 192(3). PMID: 24379123    Free PMC article.
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis.
Katherine Chang, Catherine Svabek, +11 authors, Richard Hotchkiss.
Crit Care, 2014 Jan 07; 18(1). PMID: 24387680    Free PMC article.
Highly Cited.
Combinatorial immunotherapy of polyinosinic-polycytidylic acid and blockade of programmed death-ligand 1 induce effective CD8 T-cell responses against established tumors.
Toshihiro Nagato, Young-Ran Lee, Yasuaki Harabuchi, Esteban Celis.
Clin Cancer Res, 2014 Jan 07; 20(5). PMID: 24389326    Free PMC article.
Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.
Markus Cornberg, Laurie L Kenney, +5 authors, Liisa K Selin.
Front Immunol, 2014 Jan 07; 4. PMID: 24391647    Free PMC article.
Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke.
Peiying Li, Leilei Mao, +6 authors, Xiaoming Hu.
Stroke, 2014 Feb 06; 45(3). PMID: 24496394    Free PMC article.
Crotalus durissus collilineatus Venom Induces TNF- α and IL-10 Production in Human Peripheral Blood Mononuclear Cells.
Camila Bastos Ribeiro, Jéssica Cristina Dos Santos, +5 authors, Irmtraut Araci Hoffman Pfrimer.
ISRN Inflamm, 2014 Feb 25; 2014. PMID: 24563803    Free PMC article.
T-cell immunity to infection with dengue virus in humans.
Daniela Weiskopf, Alessandro Sette.
Front Immunol, 2014 Mar 19; 5. PMID: 24639680    Free PMC article.
Highly Cited. Review.
Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection.
Anuradha Bandaru, Kamakshi P Devalraju, +5 authors, Vijayalakshmi Valluri.
Eur J Immunol, 2014 Mar 20; 44(7). PMID: 24643836    Free PMC article.
Expansion of circulating TFH cells and their associated molecules: involvement in the immune landscape in patients with chronic HBV infection.
Ting-Ting Hu, Xiao-Fei Song, +3 authors, Peng Hu.
Virol J, 2014 Mar 25; 11. PMID: 24655429    Free PMC article.
The expression of programmed death-1 in circulating CD4+ and CD8+ T cells during hepatitis B virus infection progression and its correlation with clinical baseline characteristics.
Ping Xu, Yong-Jing Chen, +4 authors, Xue-Feng Wang.
Gut Liver, 2014 Mar 29; 8(2). PMID: 24672661    Free PMC article.
Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy.
Fernando Aranda, Erika Vacchelli, +5 authors, Lorenzo Galluzzi.
Oncoimmunology, 2014 Apr 05; 3(1). PMID: 24701370    Free PMC article.
Highly Cited.
Adaptive immune response during hepatitis C virus infection.
Juan Ramón Larrubia, Elia Moreno-Cubero, +5 authors, Eduardo Sanz-de-Villalobos.
World J Gastroenterol, 2014 Apr 08; 20(13). PMID: 24707125    Free PMC article.
Review.
Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis.
Joanne Boldison, Colin J Chu, +4 authors, Lindsay B Nicholson.
J Immunol, 2014 Apr 18; 192(10). PMID: 24740509    Free PMC article.
Dysfunctional adaptive immunity during parasitic infections.
Ryan A Zander, Noah S Butler.
Curr Immunol Rev, 2014 May 20; 9(3). PMID: 24839433    Free PMC article.
B cells with immune-regulating function in transplantation.
Jessica Stolp, Laurence A Turka, Kathryn J Wood.
Nat Rev Nephrol, 2014 May 23; 10(7). PMID: 24846332
Review.
Association of T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) polymorphisms with susceptibility and disease progression of HBV infection.
Jingyu Liao, Qi Zhang, +4 authors, Lanlan Wang.
PLoS One, 2014 May 29; 9(5). PMID: 24867713    Free PMC article.
Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development.
Thomas Tu, Magdalena A Budzinska, +6 authors, Nicholas A Shackel.
Int J Mol Sci, 2014 May 30; 15(6). PMID: 24871369    Free PMC article.
Review.
Malaria drives T cells to exhaustion.
Michelle N Wykes, Joshua M Horne-Debets, Chiuan-Yee Leow, Deshapriya S Karunarathne.
Front Microbiol, 2014 Jun 07; 5. PMID: 24904561    Free PMC article.
Review.
DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth.
Jin-Sung Chung, Kyoichi Tamura, Ponciano D Cruz, Kiyoshi Ariizumi.
J Invest Dermatol, 2014 Jun 18; 134(11). PMID: 24936834    Free PMC article.
Immunization-induced Anaplasma marginale-specific T-lymphocyte responses impaired by A. marginale infection are restored after eliminating infection with tetracycline.
Joshua E Turse, Glen A Scoles, +2 authors, Wendy C Brown.
Clin Vaccine Immunol, 2014 Jul 11; 21(9). PMID: 25008904    Free PMC article.
Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity.
Arun Chauhan, Yuyang Sun, +4 authors, Bibhuti B Mishra.
PLoS One, 2014 Jul 12; 9(7). PMID: 25013939    Free PMC article.
Targeting apoptosis in autoimmune hepatitis.
Albert J Czaja.
Dig Dis Sci, 2014 Jul 21; 59(12). PMID: 25038736
Review.
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Lunxian Tang, Jianwen Bai, +4 authors, Alfred Ayala.
Shock, 2014 Jul 25; 43(1). PMID: 25057927    Free PMC article.
CD160 isoforms and regulation of CD4 and CD8 T-cell responses.
Mohamed El-Far, Charles Pellerin, +8 authors, George Kukolj.
J Transl Med, 2014 Sep 03; 12. PMID: 25179432    Free PMC article.
Combining radiation and immunotherapy: a new systemic therapy for solid tumors?
Chad Tang, Xiaohong Wang, +14 authors, James W Welsh.
Cancer Immunol Res, 2014 Sep 05; 2(9). PMID: 25187273    Free PMC article.
Highly Cited. Review.
Role of biphasic changes in splenic dendritic cell activity in a mouse model of multiple organ dysfunction syndrome.
Yi Lv, Qian Liu, +2 authors, Jiangyang Lu.
Int J Clin Exp Pathol, 2014 Sep 10; 7(8). PMID: 25197343    Free PMC article.
PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis.
Min Li, Jiandong Jiang, +9 authors, Xueguang Zhang.
Neural Regen Res, 2014 Sep 11; 8(35). PMID: 25206651    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
CD4+ T cells promote antibody production but not sustained affinity maturation during Borrelia burgdorferi infection.
Rebecca A Elsner, Christine J Hastey, Nicole Baumgarth.
Infect Immun, 2014 Oct 15; 83(1). PMID: 25312948    Free PMC article.
Antigen-induced regulation of T-cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.
Sten-Erik Bergström, Mehmet Uzunel, +2 authors, Karl-Gösta Sundqvist.
Immunology, 2014 Nov 14; 144(4). PMID: 25393517    Free PMC article.
Immunotherapy for primary brain tumors: no longer a matter of privilege.
Peter E Fecci, Amy B Heimberger, John H Sampson.
Clin Cancer Res, 2014 Nov 16; 20(22). PMID: 25398845    Free PMC article.
Review.
Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia.
Guang-Sheng Lei, Chen Zhang, Chao-Hung Lee.
Infect Immun, 2014 Nov 19; 83(2). PMID: 25404033    Free PMC article.
Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.
Yuichiro Shindo, Jacqueline Unsinger, +2 authors, Richard S Hotchkiss.
Shock, 2015 Jan 08; 43(4). PMID: 25565644    Free PMC article.
Phenotypic modulation of auto-reactive cells by insertion of tolerogenic molecules via MSC-derived exosomes.
Aram Mokarizadeh, Nowruz Delirezh, +3 authors, Bahram Dalir-Naghadeh.
Vet Res Forum, 2012 Oct 01; 3(4). PMID: 25653768    Free PMC article.
Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment.
Stephen J P Blake, Alan L H Ching, +4 authors, Raymond J Steptoe.
PLoS One, 2015 Mar 06; 10(3). PMID: 25741704    Free PMC article.
The role of checkpoints in the treatment of GBM.
Jennifer E Kim, Michael Lim.
J Neurooncol, 2015 Mar 10; 123(3). PMID: 25749875    Free PMC article.
Imbalance of dendritic cell co-stimulation in COPD.
Paul Stoll, Martin Ulrich, +3 authors, Marek Lommatzsch.
Respir Res, 2015 Mar 17; 16. PMID: 25775429    Free PMC article.
Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines.
Joanna J Charlton, Debbie Tsoukatou, Clio Mamalaki, Ioannis Chatzidakis.
PLoS One, 2015 Mar 25; 10(3). PMID: 25803808    Free PMC article.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Kathleen M Mahoney, Gordon J Freeman, David F McDermott.
Clin Ther, 2015 Apr 01; 37(4). PMID: 25823918    Free PMC article.
Highly Cited. Review.
Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T.
Rachel A Burga, Mitchell Thorn, +8 authors, Steven C Katz.
Cancer Immunol Immunother, 2015 Apr 09; 64(7). PMID: 25850344    Free PMC article.
Robust and sustained immune activation in human Ebola virus infection.
Judith N Mandl, Mark B Feinberg.
Proc Natl Acad Sci U S A, 2015 Apr 09; 112(15). PMID: 25852148    Free PMC article.
Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes.
Wendy C Brown, Joshua E Turse, +6 authors, Junzo Norimine.
Clin Vaccine Immunol, 2015 May 01; 22(7). PMID: 25924762    Free PMC article.
Decreased PD-1/PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal Ischemia Reperfusion.
Xu-Yu Zhang, Zi-Meng Liu, +4 authors, Ke-Xuan Liu.
Dig Dis Sci, 2015 May 07; 60(9). PMID: 25944714
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Therese Liechtenstein, Noemi Perez-Janices, +8 authors, David Escors.
Oncoimmunology, 2014 Jan 01; 3(7). PMID: 25954597    Free PMC article.
Immune checkpoint blockade and interferon-α in melanoma.
Imran Rafique, John M Kirkwood, Ahmad A Tarhini.
Semin Oncol, 2015 May 13; 42(3). PMID: 25965362    Free PMC article.
Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Review.
New and promising strategies in the management of bladder cancer.
Andrea B Apolo, Nicholas J Vogelzang, Dan Theodorescu.
Am Soc Clin Oncol Educ Book, 2015 May 21;. PMID: 25993148    Free PMC article.
Review.
Immunological markers predict the prognosis of patients with squamous non-small cell lung cancer.
Long Jiang, Zerui Zhao, +5 authors, Hao Long.
Immunol Res, 2015 May 23; 62(3). PMID: 25999209
Suppression of cell division-associated genes by Helicobacter pylori attenuates proliferation of RAW264.7 monocytic macrophage cells.
Grace Min Yi Tan, Chung Yeng Looi, +3 authors, Won Fen Wong.
Sci Rep, 2015 Jun 17; 5. PMID: 26078204    Free PMC article.
Tolerance Induction in Liver.
M H Karimi, B Geramizadeh, S A Malek-Hosseini.
Int J Organ Transplant Med, 2015 Jun 18; 6(2). PMID: 26082828    Free PMC article.
Review.
BLT humanized mice as a small animal model of HIV infection.
Marshall E Karpel, Christian L Boutwell, Todd M Allen.
Curr Opin Virol, 2015 Jun 18; 13. PMID: 26083316    Free PMC article.
Review.
CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells.
Pablo Penaloza-MacMaster, Nicholas M Provine, Eryn Blass, Dan H Barouch.
J Immunol, 2015 Jun 28; 195(3). PMID: 26116499    Free PMC article.
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in Neurocysticercosis.
Arun Chauhan, Fredice Z Quenum, +5 authors, Bibhuti B Mishra.
ASN Neuro, 2015 Jul 08; 7(4). PMID: 26148848    Free PMC article.
Assays for predicting and monitoring responses to lung cancer immunotherapy.
Cristina Teixidó, Niki Karachaliou, +2 authors, Rafael Rosell.
Cancer Biol Med, 2015 Jul 16; 12(2). PMID: 26175924    Free PMC article.
Review.
Molecular and cellular insights into T cell exhaustion.
E John Wherry, Makoto Kurachi.
Nat Rev Immunol, 2015 Jul 25; 15(8). PMID: 26205583    Free PMC article.
Highly Cited. Review.
Higher Frequency of Circulating PD-1(high) CXCR5(+)CD4(+) Tfh Cells in Patients with Chronic Schistosomiasis.
Yumei Zhang, Yanyan Jiang, +6 authors, Jianping Cao.
Int J Biol Sci, 2015 Jul 30; 11(9). PMID: 26221072    Free PMC article.
Programmed death-1 (PD-1) polymorphism is associated with gastric cardia adenocarcinoma.
Weifeng Tang, Yu Chen, +3 authors, Mingqiang Kang.
Int J Clin Exp Med, 2015 Jul 30; 8(5). PMID: 26221374    Free PMC article.
The role of programmed death ligand 1 pathway in persistent biomaterial-associated infections.
Agnieszka Magryś, Jolanta Paluch-Oleś, +3 authors, Maria Kozioł-Montewka.
J Microbiol, 2015 Aug 01; 53(8). PMID: 26224457
Expression of PD-1 by CD4(+)CD25(+)CD127(low) Treg cells in the peripheral blood of lung cancer patients.
AnYuan Zhong, Xue Pan, MinHua Shi.
Onco Targets Ther, 2015 Aug 01; 8. PMID: 26229490    Free PMC article.
Sepsis: From Pathophysiology to Individualized Patient Care.
Ildikó László, Domonkos Trásy, Zsolt Molnár, János Fazakas.
J Immunol Res, 2015 Aug 11; 2015. PMID: 26258150    Free PMC article.
Review.
Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells.
Jonathan Kevin Sia, Maria Georgieva, Jyothi Rengarajan.
J Immunol Res, 2015 Aug 11; 2015. PMID: 26258152    Free PMC article.
Review.
Comparison of biomarkers for systemic juvenile idiopathic arthritis.
Susan Shenoi, Jing-Ni Ou, +5 authors, Anne M Stevens.
Pediatr Res, 2015 Aug 13; 78(5). PMID: 26267155
Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming.
Martha Sedegah, Michael R Hollingdale, +9 authors, Eileen Villasante.
Hum Vaccin Immunother, 2015 Aug 21; 11(11). PMID: 26292027    Free PMC article.
Programmed Death 1 (PD-1) is involved in the development of proliferative diabetic retinopathy by mediating activation-induced apoptosis.
Mengyuan Fang, Qianli Meng, +7 authors, Jiening Zhu.
Mol Vis, 2015 Sep 01; 21. PMID: 26321864    Free PMC article.
Human Cancer Immunotherapy with PD-1/PD-L1 Blockade.
Peilin Zheng, Zhiguang Zhou.
Biomark Cancer, 2015 Oct 09; 7(Suppl 2). PMID: 26448693    Free PMC article.
Review.
PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells.
Kathleen M Mahoney, Heather Sun, +8 authors, Gordon J Freeman.
Cancer Immunol Res, 2015 Nov 08; 3(12). PMID: 26546452    Free PMC article.
Highly Cited.
Association of programmed death-1 gene polymorphism rs2227981 with tumor: evidence from a meta analysis.
Umarjan Mamat, Muyassar Arkinjan.
Int J Clin Exp Med, 2015 Nov 10; 8(8). PMID: 26550254    Free PMC article.
Melanoma: oncogenic drivers and the immune system.
Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell.
Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311    Free PMC article.
Review.
ADMIRE: analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay.
Jens Preussner, Julia Bayer, Carsten Kuenne, Mario Looso.
Epigenetics Chromatin, 2015 Dec 03; 8. PMID: 26628921    Free PMC article.
Polymorphisms of co-inhibitory molecules (CTLA-4/PD-1/PD-L1) and the risk of non-small cell lung cancer in a Chinese population.
Yuan Ma, Xiuchun Liu, +6 authors, Liu Jie.
Int J Clin Exp Med, 2015 Dec 03; 8(9). PMID: 26629188    Free PMC article.
Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.
Robert M Paris, Constantinos Petrovas, +11 authors, Richard A Koup.
PLoS One, 2015 Dec 19; 10(12). PMID: 26678998    Free PMC article.
Characterization of age-associated exhausted CD8⁺ T cells defined by increased expression of Tim-3 and PD-1.
Kyoo-A Lee, Kwang-Soo Shin, +5 authors, Chang-Yuil Kang.
Aging Cell, 2016 Jan 12; 15(2). PMID: 26750587    Free PMC article.
T cells from patients with Candida sepsis display a suppressive immunophenotype.
Andrej Spec, Yuichiro Shindo, +6 authors, Richard S Hotchkiss.
Crit Care, 2016 Jan 21; 20. PMID: 26786705    Free PMC article.
An increased number of PD-1+ and Tim-3+ CD8+ T cells is involved in immune evasion in gastric cancer.
Shuichi Takano, Hiroaki Saito, Masahide Ikeguchi.
Surg Today, 2016 Jan 24; 46(11). PMID: 26801344
Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.
Peggy P Ho, Lawrence Steinman.
Proc Natl Acad Sci U S A, 2016 Jan 27; 113(6). PMID: 26811456    Free PMC article.
Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.
Cherie T Ng, Juan L Mendoza, K Christopher Garcia, Michael B A Oldstone.
Cell, 2016 Jan 30; 164(3). PMID: 26824652    Free PMC article.
Highly Cited. Review.
How Cancers Escape Immune Destruction and Mechanisms of Action for the New Significantly Active Immune Therapies: Helping Nonimmunologists Decipher Recent Advances.
Jonathan L Messerschmidt, George C Prendergast, Gerald L Messerschmidt.
Oncologist, 2016 Feb 03; 21(2). PMID: 26834161    Free PMC article.
Review.
Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages.
Toshiaki Shimizu, Yutaka Tatano, Haruaki Tomioka.
Sci Rep, 2016 Feb 13; 6. PMID: 26868163    Free PMC article.
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.
Alison Taylor, James A Harker, +3 authors, Christopher E Rudd.
Immunity, 2016 Feb 18; 44(2). PMID: 26885856    Free PMC article.
Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients.
Marius Ilie, Véronique Hofman, +2 authors, Paul Hofman.
Virchows Arch, 2016 Feb 26; 468(5). PMID: 26915032
Highly Cited. Review.
The Role of γδ T Cells in Systemic Lupus Erythematosus.
Meng Wu, Jinhua Yang, Xiaofeng Li, Junwei Chen.
J Immunol Res, 2016 Mar 17; 2016. PMID: 26981547    Free PMC article.
Review.
PD-L1 Expression in Lung Cancer.
Hui Yu, Theresa A Boyle, +2 authors, Fred R Hirsch.
J Thorac Oncol, 2016 Apr 28; 11(7). PMID: 27117833    Free PMC article.
Highly Cited. Review.
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.
Eloah Rabello Suarez, De Kuan Chang, +5 authors, Wayne A Marasco.
Oncotarget, 2016 May 05; 7(23). PMID: 27145284    Free PMC article.
Highly Cited.
ENGAGE- 501: phase II study of entinostat (SNDX-275) in relapsed and refractory Hodgkin lymphoma.
Connie Lee Batlevi, Yvette Kasamon, +10 authors, Anas Younes.
Haematologica, 2016 May 07; 101(8). PMID: 27151994    Free PMC article.
Monocyte programmed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study.
Rui Shao, Yingying Fang, +3 authors, Chun-Sheng Li.
Crit Care, 2016 May 10; 20(1). PMID: 27156867    Free PMC article.
Emerging molecular classifications and therapeutic implications for gastric cancer.
Tao Chen, Xiao-Yue Xu, Ping-Hong Zhou.
Chin J Cancer, 2016 May 29; 35. PMID: 27233623    Free PMC article.
Review.
Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients.
Edwin R Parra, Carmen Behrens, +15 authors, Ignacio I Wistuba.
Clin Cancer Res, 2016 Jun 03; 22(24). PMID: 27252415    Free PMC article.
The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats.
Mei Tian, Yonghong Zhang, +3 authors, Aihua Liao.
Sci Rep, 2016 Jun 10; 6. PMID: 27277012    Free PMC article.
Expression of PD-L1 in triple-negative breast cancer based on different immunohistochemical antibodies.
Woo Young Sun, Yu Kyung Lee, Ja Seung Koo.
J Transl Med, 2016 Jun 12; 14(1). PMID: 27286842    Free PMC article.
Lymphocyte-activation gene-3, an important immune checkpoint in cancer.
Yayi He, Christopher J Rivard, +5 authors, Fred R Hirsch.
Cancer Sci, 2016 Jun 15; 107(9). PMID: 27297395    Free PMC article.
Highly Cited. Review.
Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy.
Chang-Ae Shin, Hyun-Woo Cho, +3 authors, Tai-Gyu Kim.
Oncotarget, 2016 Jun 22; 7(29). PMID: 27323820    Free PMC article.
The Expression of Programmed Death-1 on CD4+ and CD8+ T Lymphocytes in Patients with Type 2 Diabetes and Severe Sepsis.
Yumei Jia, Yongzhen Zhao, Chunsheng Li, Rui Shao.
PLoS One, 2016 Jul 28; 11(7). PMID: 27459386    Free PMC article.
Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma.
Hans A Schlößer, Uta Drebber, +20 authors, Michael von Bergwelt-Baildon.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467911    Free PMC article.
Evaluation of the pharmacokinetics and metabolism of pembrolizumab in the treatment of melanoma.
Teresa C Longoria, Krishnansu S Tewari.
Expert Opin Drug Metab Toxicol, 2016 Aug 04; 12(10). PMID: 27485741    Free PMC article.
Review.
Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer.
Kazuhiko Shien, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba.
Lung Cancer, 2016 Aug 28; 99. PMID: 27565919    Free PMC article.
Review.
PD-L1 expression in human cancers and its association with clinical outcomes.
Xin Wang, Feifei Teng, Li Kong, Jinming Yu.
Onco Targets Ther, 2016 Aug 31; 9. PMID: 27574444    Free PMC article.
Highly Cited. Review.
Dendritic cells and parasites: from recognition and activation to immune response instruction.
Claudia Cristina Motran, Laura Fernanda Ambrosio, +2 authors, Laura Cervi.
Semin Immunopathol, 2016 Sep 03; 39(2). PMID: 27587063
Review.
PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma.
Asma Beldi-Ferchiou, Marion Lambert, +10 authors, Sophie Caillat-Zucman.
Oncotarget, 2016 Sep 24; 7(45). PMID: 27662664    Free PMC article.
Highly Cited.
Programmed death-1+ T cells inhibit effector T cells at the pathological site of miliary tuberculosis.
A Singh, A Mohan, A B Dey, D K Mitra.
Clin Exp Immunol, 2016 Sep 27; 187(2). PMID: 27665733    Free PMC article.
B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.
Luisa Klotz, Ivan Kuzmanov, +13 authors, Heinz Wiendl.
Proc Natl Acad Sci U S A, 2016 Sep 28; 113(41). PMID: 27671636    Free PMC article.
Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2+ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis.
José L Reyes, Fernando Lopes, +7 authors, Derek M McKay.
Infect Immun, 2016 Sep 28; 84(12). PMID: 27672083    Free PMC article.
Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells.
Haiyan S Li, Chengwen Liu, +8 authors, Stephanie S Watowich.
Sci Signal, 2016 Sep 30; 9(447). PMID: 27678219    Free PMC article.
Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer.
Eileen E Parkes, Steven M Walker, +12 authors, Richard D Kennedy.
J Natl Cancer Inst, 2016 Oct 07; 109(1). PMID: 27707838    Free PMC article.
Highly Cited.
Near infrared photoimmunotherapy with avelumab, an anti-programmed death-ligand 1 (PD-L1) antibody.
Tadanobu Nagaya, Yuko Nakamura, +5 authors, Hisataka Kobayashi.
Oncotarget, 2016 Oct 08; 8(5). PMID: 27716622    Free PMC article.
Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma.
Hiroyuki Inoue, Jae-Hyun Park, +16 authors, Yusuke Nakamura.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757299    Free PMC article.
A Novel Role for Programmed Cell Death Receptor Ligand-1 (PD-L1) in Sepsis-Induced Intestinal Dysfunction.
Youping Wu, Chun-Shiang Chung, +5 authors, Alfred Ayala.
Mol Med, 2016 Oct 27; 22. PMID: 27782294    Free PMC article.
PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection.
Cinthia C Stempin, Claudia C Motrán, +3 authors, Laura Cervi.
Oncotarget, 2016 Oct 27; 7(47). PMID: 27783986    Free PMC article.
A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.
Bridgette Janine Connell, Sui-Yuan Chang, +8 authors, Hugues Lortat-Jacob.
PLoS One, 2016 Oct 28; 11(10). PMID: 27788205    Free PMC article.
Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse.
Valerio Nardone, Cirino Botta, +18 authors, Pierpaolo Correale.
Cancer Biol Ther, 2016 Oct 30; 17(11). PMID: 27791459    Free PMC article.
Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica.
Sha Zhou, Xin Jin, +8 authors, Chuan Su.
PLoS Negl Trop Dis, 2016 Oct 30; 10(10). PMID: 27792733    Free PMC article.
STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.
Shinya Hidano, Louise M Randall, +12 authors, Christopher A Hunter.
mBio, 2016 Nov 12; 7(6). PMID: 27834206    Free PMC article.
IL-1β, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis.
Emmanuel Stephen-Victor, Varun Kumar Sharma, +6 authors, Jagadeesh Bayry.
Front Immunol, 2016 Nov 22; 7. PMID: 27867382    Free PMC article.
Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.
Camilla Margaroli, Rabindra Tirouvanziam.
Mol Cell Pediatr, 2016 Nov 22; 3(1). PMID: 27868161    Free PMC article.
Review.
KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer.
Yayi He, Paul A Bunn, Caicun Zhou, Dan Chan.
Oncotarget, 2016 Nov 29; 7(50). PMID: 27893413    Free PMC article.
Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren's syndrome in non-obese diabetic mice.
Jing Zhou, Jun-O Jin, Toshihisa Kawai, Qing Yu.
Sci Rep, 2016 Dec 15; 6. PMID: 27966604    Free PMC article.
PD-L1, PD-L2 and PD-1 expression in metastatic melanoma: Correlation with tumor-infiltrating immune cells and clinical outcome.
Joseph M Obeid, Gulsun Erdag, +5 authors, Craig L Slingluff.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999753    Free PMC article.
Model-Based Population Pharmacokinetic Analysis of Nivolumab in Patients With Solid Tumors.
G Bajaj, X Wang, +3 authors, Y Feng.
CPT Pharmacometrics Syst Pharmacol, 2016 Dec 27; 6(1). PMID: 28019091    Free PMC article.
Highly Cited.
Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis.
Christina Tejeda, Alaine K Broadaway, +10 authors, Sampath Prahalad.
Curr Rheumatol Rev, 2017 Jan 07; 13(3). PMID: 28056736    Free PMC article.
Increased PD-1 Expression and Altered T Cell Repertoire Diversity Predict Mortality in Patients with Septic Shock: A Preliminary Study.
Atsutoshi Tomino, Masanobu Tsuda, +5 authors, Naoshi Takeyama.
PLoS One, 2017 Jan 11; 12(1). PMID: 28072859    Free PMC article.
An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage.
J H Southcombe, G Mounce, +5 authors, I Granne.
Sci Rep, 2017 Jan 24; 7. PMID: 28112260    Free PMC article.
Host controls of HIV broadly neutralizing antibody development.
Garnett Kelsoe, Barton F Haynes.
Immunol Rev, 2017 Jan 31; 275(1). PMID: 28133807    Free PMC article.
Highly Cited. Review.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells.
Taiji Mizoguchi, Kazuyuki Kasahara, +9 authors, Ken-Ichi Hirata.
Heart Vessels, 2017 Feb 10; 32(6). PMID: 28181012
Validation of Anti-Mouse PDL-1 Goat Polyclonal Antibody Staining with Mouse PDL-1 In Situ Hybridization on Adjacent Sections of Cell Pellets and Mouse Tumors.
Jacob Ricca, Mesruh Turkekul, +7 authors, Katia Manova-Todorova.
Methods Mol Biol, 2017 Feb 12; 1554. PMID: 28185198    Free PMC article.
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.
Eszter Lázár-Molnár, Lisa Scandiuzzi, +7 authors, Steven C Almo.
EBioMedicine, 2017 Feb 25; 17. PMID: 28233730    Free PMC article.
PD-1, PD-L1 Protein Expression in Non-Small Cell Lung Cancer and Their Relationship with Tumor-Infiltrating Lymphocytes.
Yayi He, Leslie Rozeboom, +5 authors, Fred R Hirsch.
Med Sci Monit, 2017 Mar 10; 23. PMID: 28275222    Free PMC article.
Programming T cell Killers for an HIV Cure: Teach the New Dogs New Tricks and Let the Sleeping Dogs Lie.
Kellie N Smith, Robbie B Mailliard, Charles R Rinaldo.
For Immunopathol Dis Therap, 2015 Jan 01; 6(1-2). PMID: 28344852    Free PMC article.
Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
Saly Al-Taei, Josephine Salimu, +3 authors, Zsuzsanna Tabi.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344879    Free PMC article.
Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone.
Megan L Cramer, Guohong Shao, +2 authors, Paul T Martin.
Hum Gene Ther, 2017 Mar 28; 28(6). PMID: 28345428    Free PMC article.
Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis.
Qiang Liu, Chun-Sheng Li.
Chin Med J (Engl), 2017 Apr 12; 130(8). PMID: 28397730    Free PMC article.
Review.
Vitamin D increases programmed death receptor-1 expression in Crohn's disease.
Mia Bendix, Stinne Greisen, +6 authors, Jørgen Agnholt.
Oncotarget, 2017 Apr 17; 8(15). PMID: 28412753    Free PMC article.
Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.
Laurent Verkoczy.
Adv Immunol, 2017 Apr 18; 134. PMID: 28413022    Free PMC article.
Review.
The use of immunotherapy in the treatment of melanoma.
Tala Achkar, Ahmad A Tarhini.
J Hematol Oncol, 2017 Apr 25; 10(1). PMID: 28434398    Free PMC article.
Review.
PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma.
Jacqueline Fontugne, Jérémy Augustin, +8 authors, Julien Calderaro.
Oncotarget, 2017 Apr 28; 8(15). PMID: 28445951    Free PMC article.
Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.
Pankaj Seth, Eva Csizmadia, +5 authors, Barbara Wegiel.
Cancer Res, 2017 Apr 28; 77(13). PMID: 28446465    Free PMC article.
PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC).
Liyan Jiang, Xinying Su, +18 authors, Yi Gu.
Oncotarget, 2017 May 04; 8(16). PMID: 28460468    Free PMC article.
"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.
Cesar Boggiano, Katrin Eichelberg, +7 authors, Hardy Kornfeld.
Vaccine, 2017 May 10; 35(27). PMID: 28476627    Free PMC article.
Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.
Katarzyna Bocian, Ewelina Kiernozek, +3 authors, Nadzieja Drela.
Arch Immunol Ther Exp (Warsz), 2017 May 10; 65(6). PMID: 28477096    Free PMC article.
Review.
B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes.
Mehmet Altan, Vasiliki Pelekanou, +5 authors, David L Rimm.
Clin Cancer Res, 2017 May 26; 23(17). PMID: 28539467    Free PMC article.
Circulating soluble programmed death-1 levels may differentiate immune-tolerant phase from other phases and hepatocellular carcinoma from other clinical diseases in chronic hepatitis B virus infection.
Na Li, Zhihua Zhou, +6 authors, Zhengwen Liu.
Oncotarget, 2017 May 26; 8(28). PMID: 28545019    Free PMC article.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Review.
Emerging treatment options for the management of Hodgkin's lymphoma: clinical utility of nivolumab.
David A Bond, Lapo Alinari.
J Blood Med, 2017 May 27; 8. PMID: 28546779    Free PMC article.
Review.
Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.
W Li, J Tu, X Liu, W Yang.
Clin Exp Immunol, 2017 May 31; 190(1). PMID: 28556912    Free PMC article.
T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.
Kohei Hosokawa, Sachiko Kajigaya, +5 authors, Neal S Young.
J Immunol, 2017 Jun 21; 199(2). PMID: 28630090    Free PMC article.
Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.
Antje Heit, Frank Schmitz, +9 authors, M Juliana McElrath.
J Exp Med, 2017 Jun 24; 214(7). PMID: 28637884    Free PMC article.
Highly Cited.
PD-1 and cancer: molecular mechanisms and polymorphisms.
Arash Salmaninejad, Vahid Khoramshahi, +6 authors, Sayed Mostafa Hosseini.
Immunogenetics, 2017 Jun 24; 70(2). PMID: 28642997
Review.
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Mark Ayers, Jared Lunceford, +12 authors, Terrill K McClanahan.
J Clin Invest, 2017 Jun 27; 127(8). PMID: 28650338    Free PMC article.
Highly Cited.
Decreased T helper 17 cells in tuberculosis is associated with increased percentages of programmed death ligand 1, T helper 2 and regulatory T cells.
Chin-Chung Shu, Ming-Fang Wu, +4 authors, Chong-Jen Yu.
Respir Res, 2017 Jun 28; 18(1). PMID: 28651576    Free PMC article.
Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer.
Xinxin Zhu, Jinghe Lang.
J Gynecol Oncol, 2017 Jun 29; 28(5). PMID: 28657225    Free PMC article.
Review.
Immunohistochemical Analysis of Foxp3+, CD4+, CD8+ Cell Infiltrates and PD-L1 in Oral Squamous Cell Carcinoma.
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz.
Pathol Oncol Res, 2017 Jul 03; 24(3). PMID: 28669079    Free PMC article.
BIN1 reverses PD-L1-mediated immune escape by inactivating the c-MYC and EGFR/MAPK signaling pathways in non-small cell lung cancer.
J Wang, Y Jia, +7 authors, L Liu.
Oncogene, 2017 Jul 18; 36(45). PMID: 28714960
Comparison of Different Antibody Clones for Immunohistochemistry Detection of Programmed Cell Death Ligand 1 (PD-L1) on Non-Small Cell Lung Carcinoma.
Edwin R Parra, Pamela Villalobos, Barbara Mino, Jaime Rodriguez-Canales.
Appl Immunohistochem Mol Morphol, 2017 Jul 19; 26(2). PMID: 28719380    Free PMC article.
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.
Ricardo C Ferreira, Henry Z Simons, +16 authors, Marcin L Pekalski.
J Autoimmun, 2017 Jul 28; 84. PMID: 28747257    Free PMC article.
Programmed death 1 is highly expressed on CD8+ CD57+ T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus.
Maria T Cencioni, Roberta Magliozzi, +6 authors, Paolo A Muraro.
Immunology, 2017 Aug 03; 152(4). PMID: 28767147    Free PMC article.
Prognostic value of programmed cell death protein 1 expression on CD8+ T lymphocytes in pancreatic cancer.
Tao Shen, Liangjing Zhou, +4 authors, Liping Cao.
Sci Rep, 2017 Aug 12; 7(1). PMID: 28798308    Free PMC article.
PD1 signal transduction pathways in T cells.
Hugo Arasanz, Maria Gato-Cañas, +4 authors, David Escors.
Oncotarget, 2017 Sep 09; 8(31). PMID: 28881701    Free PMC article.
Highly Cited. Review.
The altered PD-1/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg/Th17 imbalance in pre-eclampsia.
Yonghong Zhang, Zhaozhao Liu, +4 authors, Aihua Liao.
Cell Mol Immunol, 2017 Sep 12; 15(7). PMID: 28890543    Free PMC article.
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functions.
Bogusław Nedoszytko, Magdalena Lange, +10 authors, Roman Nowicki.
Postepy Dermatol Alergol, 2017 Sep 28; 34(4). PMID: 28951701    Free PMC article.
Review.
PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
Mohammad S Hossain, Ghada M Kunter, +5 authors, Edmund K Waller.
PLoS One, 2017 Sep 28; 12(9). PMID: 28953925    Free PMC article.
Checkpoint Inhibitors: Applications for Autoimmunity.
Anna S Tocheva, Adam Mor.
Curr Allergy Asthma Rep, 2017 Sep 29; 17(10). PMID: 28956259    Free PMC article.
Review.
A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments.
Anna Minchom, Parames Thavasu, +8 authors, Udai Banerji.
PLoS One, 2017 Oct 06; 12(10). PMID: 28982179    Free PMC article.
Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes.
Kurtis M Host, Sarah R Jacobs, +5 authors, Blossom Damania.
mBio, 2017 Oct 12; 8(5). PMID: 29018115    Free PMC article.
Potential Immunotherapeutics for Immunosuppression in Sepsis.
Jinwook Shin, Mirim Jin.
Biomol Ther (Seoul), 2017 Oct 31; 25(6). PMID: 29081088    Free PMC article.
Review.
Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer.
Nicola Carlomagno, Paola Incollingo, +12 authors, Michele Santangelo.
Biomed Res Int, 2017 Nov 03; 2017. PMID: 29094049    Free PMC article.
Review.
Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy.
Miren Zuazo, Maria Gato-Cañas, +4 authors, David Escors.
Ann Transl Med, 2017 Nov 09; 5(19). PMID: 29114543    Free PMC article.
Review.
Quantitative label-free proteomic analysis of human urine to identify novel candidate protein biomarkers for schistosomiasis.
Olugbenga Samson Onile, Bridget Calder, +2 authors, Jonathan M Blackburn.
PLoS Negl Trop Dis, 2017 Nov 09; 11(11). PMID: 29117212    Free PMC article.
Dynamic Changes in Host Gene Expression following In Vitro Viral Mimic Stimulation in Crocodile Cells.
Subir Sarker, Yinan Wang, Brenden Warren-Smith, Karla J Helbig.
Front Immunol, 2017 Dec 08; 8. PMID: 29213275    Free PMC article.
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Zijun Y Xu-Monette, Mingzhi Zhang, Jianyong Li, Ken H Young.
Front Immunol, 2017 Dec 20; 8. PMID: 29255458    Free PMC article.
Highly Cited. Review.
Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens.
Kazuma Kiyotani, Hiu Ting Chan, Yusuke Nakamura.
Cancer Sci, 2017 Dec 31; 109(3). PMID: 29288513    Free PMC article.
Review.
Mycoplasma bovis-Induced Inhibition of Bovine Peripheral Blood Mononuclear Cell Proliferation Is Ameliorated after Blocking the Immune-Inhibitory Programmed Death 1 Receptor.
Muhammad Suleman, Farhan S Cyprian, +4 authors, Jose Perez-Casal.
Infect Immun, 2018 Jan 10; 86(3). PMID: 29311234    Free PMC article.
Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5- CD8+ T Cells during Chronic HIV Infection.
Yan-Mei Jiao, Hong-Ge Yang, +15 authors, Fu-Sheng Wang.
Front Immunol, 2018 Jan 10; 8. PMID: 29312314    Free PMC article.
Perspective on immune oncology with liquid biopsy, peripheral blood mononuclear cells, and microbiome with non-invasive biomarkers in cancer patients.
A Mitsuhashi, Y Okuma.
Clin Transl Oncol, 2018 Jan 10; 20(8). PMID: 29313208
Review.
Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer.
Jiajia Zhang, Christopher L Wolfgang, Lei Zheng.
Cancers (Basel), 2018 Feb 02; 10(2). PMID: 29385739    Free PMC article.
Review.
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis.
Eleanor A Fallon, Bethany M Biron-Girard, +4 authors, Alfred Ayala.
J Leukoc Biol, 2018 Feb 03;. PMID: 29393983    Free PMC article.
Review.
Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.
Sitanshu S Singh, Seetharama D Jois.
Adv Protein Chem Struct Biol, 2018 Feb 21; 111. PMID: 29459028    Free PMC article.
Review.
Surface receptor Toso controls B cell-mediated regulation of T cell immunity.
Jinbo Yu, Vu Huy Hoang Duong, +7 authors, Kyeong-Hee Lee.
J Clin Invest, 2018 Feb 21; 128(5). PMID: 29461978    Free PMC article.
A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma.
Tadashi Sakane, Takayuki Murase, +11 authors, Hiroshi Inagaki.
Oncotarget, 2018 Feb 23; 9(6). PMID: 29467945    Free PMC article.
Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.
Zhongfang Wang, Lingyan Zhu, +27 authors, Katherine Kedzierska.
Nat Commun, 2018 Feb 28; 9(1). PMID: 29483513    Free PMC article.
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
Dmitriy Zamarin, Jacob M Ricca, +7 authors, Jedd D Wolchok.
J Clin Invest, 2018 Mar 06; 128(4). PMID: 29504948    Free PMC article.
Highly Cited.
Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen.
Niwa Ali, Bahar Zirak, +4 authors, Michael D Rosenblum.
J Immunol, 2018 Mar 23; 200(9). PMID: 29563179    Free PMC article.
The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas.
Luyan Mu, Yu Long, +12 authors, Jianping Huang.
Front Mol Neurosci, 2018 Apr 13; 11. PMID: 29643764    Free PMC article.
PD-L1 expression testing in non-small cell lung cancer.
Cristina Teixidó, Noelia Vilariño, Roxana Reyes, Noemí Reguart.
Ther Adv Med Oncol, 2018 Apr 18; 10. PMID: 29662547    Free PMC article.
Highly Cited. Review.
Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management.
Albert J Czaja.
Dig Dis Sci, 2018 Apr 20; 63(7). PMID: 29671161
Review.
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?
Laura de Ramon, Jordi Guiteras, +3 authors, Juan Torras.
Int J Mol Sci, 2018 Apr 26; 19(5). PMID: 29693595    Free PMC article.
Review.
High Serum Level of Soluble Programmed Death Ligand 1 is Associated With a Poor Prognosis in Hodgkin Lymphoma.
Xiaofang Guo, Juan Wang, +7 authors, Xiaofei Sun.
Transl Oncol, 2018 Apr 27; 11(3). PMID: 29698935    Free PMC article.
The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC.
Yayi He, Sangtian Liu, +3 authors, Daniel Chan.
Drug Des Devel Ther, 2018 May 08; 12. PMID: 29731605    Free PMC article.
The design of high affinity human PD-1 mutants by using molecular dynamics simulations (MD).
Jiangfeng Du, Yaping Qin, +5 authors, Yanfeng Gao.
Cell Commun Signal, 2018 Jun 09; 16(1). PMID: 29879980    Free PMC article.
Biomaterials at the interface of nano- and micro-scale vector-cellular interactions in genetic vaccine design.
Charles H Jones, Anders P Hakansson, Blaine A Pfeifer.
J Mater Chem B, 2014 Jan 01; 46. PMID: 29887986    Free PMC article.
Construction of an anti-programmed death-ligand 1 chimeric antigen receptor and determination of its antitumor function with transduced cells.
Jiasen Xie, Zishan Zhou, Shunchang Jiao, Xiaokun Li.
Oncol Lett, 2018 Jun 22; 16(1). PMID: 29928397    Free PMC article.
Key questions about the checkpoint blockade-are microRNAs an answer?
Mihnea Dragomir, Baoqing Chen, Xiao Fu, George A Calin.
Cancer Biol Med, 2018 Jun 29; 15(2). PMID: 29951335    Free PMC article.
Diagnosis and Management of Acral Lentiginous Melanoma.
Yoshiyuki Nakamura, Yasuhiro Fujisawa.
Curr Treat Options Oncol, 2018 Jun 29; 19(8). PMID: 29951919
Review.
PD-1/PD-L1 immune checkpoint inhibitors in advanced cervical cancer.
Ozlen Saglam, Jose Conejo-Garcia.
Integr Cancer Sci Ther, 2018 Jun 30; 5(2). PMID: 29955379    Free PMC article.
Biomarkers of gastric cancer: Current topics and future perspective.
Tasuku Matsuoka, Masakazu Yashiro.
World J Gastroenterol, 2018 Jul 19; 24(26). PMID: 30018477    Free PMC article.
Review.
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.
Yuli Cheng, Xing Zhu, +6 authors, Xinping Zhu.
Front Immunol, 2018 Aug 11; 9. PMID: 30093899    Free PMC article.
Programmed Cell Death-1/Programmed Death-Ligand 1 Blockade Improves Survival of Animals with Sepsis: A Systematic Review and Meta-Analysis.
Qiang Zhang, Zhijiang Qi, Bo-Liu, Chun-Sheng Li.
Biomed Res Int, 2018 Aug 31; 2018. PMID: 30159323    Free PMC article.
Systematic Review.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Review.
PD-1 has a unique capacity to inhibit allergen-specific human CD4+ T cell responses.
Sandra Rosskopf, Beatrice Jahn-Schmid, +2 authors, Peter Steinberger.
Sci Rep, 2018 Sep 12; 8(1). PMID: 30201974    Free PMC article.
Personal history of infections and immunotherapy: Unexpected links and possible therapeutic opportunities.
Camille Jacqueline, Nathalie Bonnefoy, +2 authors, Benjamin Roche.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221066    Free PMC article.
Review.
Not All Immune Checkpoints Are Created Equal.
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger.
Front Immunol, 2018 Sep 21; 9. PMID: 30233564    Free PMC article.
Highly Cited. Review.
The intracellular signalosome of PD-L1 in cancer cells.
David Escors, María Gato-Cañas, +4 authors, Grazyna Kochan.
Signal Transduct Target Ther, 2018 Oct 03; 3. PMID: 30275987    Free PMC article.
Highly Cited. Review.
Elevated serum soluble programmed cell death ligand 1 concentration as a potential marker for poor prognosis in small cell lung cancer patients with chemotherapy.
Jianjun Jin, Jiming Si, +3 authors, Jing Wang.
Respir Res, 2018 Oct 07; 19(1). PMID: 30290817    Free PMC article.
The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2α and ATF4 in Lung Cancer.
Liang-Che Chang, Tzu-Ping Chen, Wei-Ke Kuo, Chung-Ching Hua.
Dis Markers, 2018 Oct 12; 2018. PMID: 30305853    Free PMC article.
On the Road to Immunotherapy-Prospects for Treating Head and Neck Cancers With Checkpoint Inhibitor Antibodies.
Frank J Ward, Lekh N Dahal, Rasha Abu-Eid.
Front Immunol, 2018 Oct 16; 9. PMID: 30319637    Free PMC article.
Review.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression.
Elena Gianchecchi, Alessandra Fierabracci.
Front Immunol, 2018 Nov 06; 9. PMID: 30386337    Free PMC article.
Highly Cited. Review.
Activated pulmonary tuberculosis in a patient with melanoma during PD-1 inhibition: a case report.
Wan He, Xiangmei Zhang, +6 authors, Peize Zhang.
Onco Targets Ther, 2018 Nov 15; 11. PMID: 30425530    Free PMC article.
Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.
J Klingström, A Smed-Sörensen, +4 authors, H G Ljunggren.
J Intern Med, 2019 Jan 22; 285(5). PMID: 30663801    Free PMC article.
Review.
PD1+CCR2+CD8+ T Cells Infiltrate the Central Nervous System during Acute Japanese Encephalitis Virus Infection.
Fang Zhang, Linlin Qi, +5 authors, Bin Wei.
Virol Sin, 2019 Jun 20; 34(5). PMID: 31215000    Free PMC article.
Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke.
Hilary A Seifert, Wenbin Zhu, +2 authors, Halina Offner.
Metab Brain Dis, 2019 Aug 15; 34(6). PMID: 31410774    Free PMC article.
Programmed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab Therapy in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC).
Lorena Incorvaia, Daniele Fanale, +10 authors, Antonio Russo.
Adv Ther, 2019 Aug 23; 36(10). PMID: 31432460    Free PMC article.
Review.
αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion.
Andrea Vannini, Valerio Leoni, +5 authors, Tatiana Gianni.
Proc Natl Acad Sci U S A, 2019 Sep 19; 116(40). PMID: 31527243    Free PMC article.
Molecular Modeling Studies on the Binding Mode of the PD-1/PD-L1 Complex Inhibitors.
Suliman Almahmoud, Haizhen A Zhong.
Int J Mol Sci, 2019 Sep 25; 20(18). PMID: 31546905    Free PMC article.
Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4)- and Programmed Death 1 (PD-1)-Mediated Regulation of Monofunctional and Dual Functional CD4+ and CD8+ T-Cell Responses in a Chronic Helminth Infection.
Anuradha Rajamanickam, Saravanan Munisankar, +2 authors, Subash Babu.
Infect Immun, 2019 Oct 02; 87(12). PMID: 31570560    Free PMC article.
Hepatic expression of programmed death-1 (PD-1) and its ligand, PD-L1, in children with autoimmune hepatitis: relation to treatment response.
Hala A Agina, Nermine A Ehsan, +3 authors, Mostafa M Sira.
Clin Exp Hepatol, 2019 Oct 11; 5(3). PMID: 31598564    Free PMC article.
Recall Responses from Brain-Resident Memory CD8+ T Cells (bTRM) Induce Reactive Gliosis.
Sujata Prasad, Shuxian Hu, +2 authors, James R Lokensgard.
iScience, 2019 Oct 28; 20. PMID: 31655062    Free PMC article.
Immunomodulatory aspects in the progression and treatment of oral malignancy.
Nobuo Kondoh, Masako Mizuno-Kamiya, +5 authors, Shinichiro Sumitomo.
Jpn Dent Sci Rev, 2019 Oct 30; 55(1). PMID: 31660091    Free PMC article.
Review.
Precision medicine in gastric cancer.
Patrizia Bonelli, Antonella Borrelli, +3 authors, Franco Maria Buonaguro.
World J Gastrointest Oncol, 2019 Oct 31; 11(10). PMID: 31662821    Free PMC article.
Review.
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Franz Fenninger, Jeffrey Han, +8 authors, Wilfred A Jefferies.
Front Immunol, 2019 Nov 19; 10. PMID: 31736943    Free PMC article.
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy.
Madiha Saeed, Jing Gao, +2 authors, Haijun Yu.
Theranostics, 2019 Nov 23; 9(26). PMID: 31754376    Free PMC article.
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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity.
Lucien P Garo, Amrendra K Ajay, +8 authors, Gopal Murugaiyan.
Cell Rep, 2019 Sep 26; 28(13). PMID: 31553906    Free PMC article.
Population Pharmacokinetics of Nivolumab in Combination With Ipilimumab in Patients With Advanced Malignancies.
Jason Zhang, Kinjal Sanghavi, +6 authors, Li Zhu.
CPT Pharmacometrics Syst Pharmacol, 2019 Nov 12; 8(12). PMID: 31710163    Free PMC article.
Optimizing Strategies for Immune Checkpoint Imaging with Immuno-PET in Preclinical Study.
Jiale Chen, Ning Wang, Xinyu Yang, Yuan Li.
J Nucl Med, 2017 Nov 18; 59(4). PMID: 29146696    Free PMC article.
Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review.
Shaheen Khan, David E Gerber.
Semin Cancer Biol, 2019 Jul 23; 64. PMID: 31330185    Free PMC article.
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The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.
Neha Shah, Sabina Sandigursky, Adam Mor.
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PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma.
Ozlen Saglam, Junmin Zhou, Xuefeng Wang, Jose R Conejo-Garcia.
Int J Gynecol Pathol, 2019 Jul 06; 39(5). PMID: 31274701    Free PMC article.
Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy.
Yuting Liu, Jon Zugazagoitia, +5 authors, David L Rimm.
Clin Cancer Res, 2019 Oct 17; 26(4). PMID: 31615933    Free PMC article.
PD-L1 expression in gastric cancer determined by digital image analyses: pitfalls and correlation with pathologist interpretation.
Han-Na Kim, Jiryeon Jang, +8 authors, Kyoung-Mee Kim.
Virchows Arch, 2019 Aug 30; 476(2). PMID: 31463730
Recent advances in the clinical development of immune checkpoint blockade therapy.
Atefeh Ghahremanloo, Arash Soltani, Seyed Mohamad Sadegh Modaresi, Seyed Isaac Hashemy.
Cell Oncol (Dordr), 2019 Jun 16; 42(5). PMID: 31201647
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T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.
Pamela D Winterberg, Jennifer M Robertson, +2 authors, Mandy L Ford.
J Am Soc Nephrol, 2019 Feb 08;. PMID: 30728178    Free PMC article.
Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis.
Laura C Cappelli, Mekha A Thomas, +2 authors, Erika Darrah.
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Cancer diagnosis and immunotherapy in the age of CRISPR.
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A novel role for programmed cell death receptor ligand 2 in sepsis-induced hepatic dysfunction.
Anne-Lise Rossi, Marilyn Le, +7 authors, Alfred Ayala.
Am J Physiol Gastrointest Liver Physiol, 2018 Nov 16; 316(1). PMID: 30431333    Free PMC article.
Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy.
George Fromm, Suresh de Silva, +3 authors, Taylor H Schreiber.
J Immunother Cancer, 2018 Dec 20; 6(1). PMID: 30563566    Free PMC article.
The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity.
Rebecca Faleiro, Deshapriya S Karunarathne, Joshua M Horne-Debets, Michelle Wykes.
Front Immunol, 2019 Jan 12; 9. PMID: 30631323    Free PMC article.
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The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection.
Paul David, Dominik A Megger, +6 authors, Gennadiy Zelinskyy.
Front Immunol, 2019 Feb 26; 10. PMID: 30804928    Free PMC article.
Revisiting the Tissue Microenvironment of Infectious Mononucleosis: Identification of EBV Infection in T Cells and Deep Characterization of Immune Profiles.
Mário Henrique M Barros, Gabriela Vera-Lozada, +2 authors, Gerald Niedobitek.
Front Immunol, 2019 Mar 08; 10. PMID: 30842768    Free PMC article.
Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities.
Mohammad K Khan, Tahseen H Nasti, +2 authors, Stephen J Kron.
Cancer J, 2019 Mar 22; 25(2). PMID: 30896532    Free PMC article.
Review.
CD8+ T cell exhaustion.
Makoto Kurachi.
Semin Immunopathol, 2019 Apr 17; 41(3). PMID: 30989321
Review.
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.
Andreas von Knethen, Anne Schäfer, +24 authors, Bernhard Brüne.
Theranostics, 2019 May 01; 9(7). PMID: 31037153    Free PMC article.
Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D.
Peter S Linsley, S Alice Long.
Curr Opin Endocrinol Diabetes Obes, 2019 Jun 04; 26(4). PMID: 31157632    Free PMC article.
Review.
PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer.
Trine Vilsbøll Larsen, Dianna Hussmann, Anders Lade Nielsen.
Cancer Commun (Lond), 2019 Jun 05; 39(1). PMID: 31159869    Free PMC article.
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance.
Günther Schönrich, Martin J Raftery.
Front Cell Infect Microbiol, 2019 Jul 03; 9. PMID: 31263684    Free PMC article.
Highly Cited. Review.
Loss of ICP22 in HSV-1 Elicits Immune Infiltration and Maintains Stromal Keratitis Despite Reduced Primary and Latent Virus Infectivity.
Harry H Matundan, Ujjaldeep Jaggi, Shaohui Wang, Homayon Ghiasi.
Invest Ophthalmol Vis Sci, 2019 Aug 07; 60(10). PMID: 31387116    Free PMC article.
The Role of Immune Checkpoint Blockade in Uveal Melanoma.
Anja Wessely, Theresa Steeb, +5 authors, Markus Vincent Heppt.
Int J Mol Sci, 2020 Feb 06; 21(3). PMID: 32013269    Free PMC article.
Review.
Clinico-Immunological Profile of a 67-Year-Old Woman Affected by HER2-Positive Breast Cancer and Autoimmune Dermatomyositis.
Benedetta Pellegrino, Giulia Mazzaschi, +5 authors, Antonino Musolino.
Front Oncol, 2020 Mar 12; 10. PMID: 32158689    Free PMC article.
High-Plex Predictive Marker Discovery for Melanoma Immunotherapy-Treated Patients Using Digital Spatial Profiling.
Maria I Toki, Christopher R Merritt, +7 authors, David L Rimm.
Clin Cancer Res, 2019 Jun 14; 25(18). PMID: 31189645    Free PMC article.
Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains.
Yann Sellier, Florence Marliot, +7 authors, Marianne Leruez-Ville.
Microorganisms, 2020 Jan 30; 8(2). PMID: 31991822    Free PMC article.
Kidney Complications of Immune Checkpoint Inhibitors: A Review.
Roman Shingarev, Ilya G Glezerman.
Am J Kidney Dis, 2019 Jul 16; 74(4). PMID: 31303350    Free PMC article.
Review.
Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic.
Rafi Ahmed, Michael B A Oldstone, Peter Palese.
Nat Immunol, 2007 Oct 24; 8(11). PMID: 17952044    Free PMC article.
Review.
Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody.
Camilla Christensen, Lotte K Kristensen, +2 authors, Andreas Kjaer.
Eur J Nucl Med Mol Imaging, 2019 Dec 29; 47(5). PMID: 31883023    Free PMC article.
Protective role of follicular CXCR5+CD8+ T cells against dengue virus 2 infection.
Liannv Qiu, Hong Wang, +3 authors, Zhao Zhao.
Int J Infect Dis, 2019 Mar 25; 83. PMID: 30904675    Free PMC article.
Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.
Li Tang, Juntao Yang, +10 authors, Fuchu He.
Gastroenterology, 2009 Jul 28; 137(4). PMID: 19632227    Free PMC article.
The balancing act: Immunology of leishmaniosis.
Angela J Toepp, Christine A Petersen.
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The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals.
Elliot A Philips, Antonio Garcia-España, +5 authors, Xiang-Peng Kong.
J Biol Chem, 2019 Dec 29; 295(14). PMID: 31882544    Free PMC article.
The Role of PD-1 in Acute and Chronic Infection.
Jil M Jubel, Zachary R Barbati, +2 authors, Frank A Schildberg.
Front Immunol, 2020 Apr 09; 11. PMID: 32265932    Free PMC article.
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PD-1/PD-L1 pathway: current researches in cancer.
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Regulation of programmed cell death ligand 1 expression by atypical protein kinase C lambda/iota in cutaneous angiosarcoma.
Ai Kawamura, Takuji Kawamura, +4 authors, Masanori Nakayama.
Cancer Sci, 2019 Feb 26; 110(5). PMID: 30801864    Free PMC article.
T Cell Dysfunction in Cancer Immunity and Immunotherapy.
Anliang Xia, Yan Zhang, +2 authors, Xiao-Jie Lu.
Front Immunol, 2019 Aug 06; 10. PMID: 31379886    Free PMC article.
Highly Cited. Review.
Alveolar Macrophage Dysfunction and Increased PD-1 Expression During Chronic SIV Infection of Rhesus Macaques.
Ruth Hunegnaw, Zuena Mushtaq, +2 authors, Marjorie Robert-Guroff.
Front Immunol, 2019 Jul 25; 10. PMID: 31333668    Free PMC article.
Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
Luisa Chocarro de Erauso, Miren Zuazo, +8 authors, David Escors.
Front Pharmacol, 2020 Apr 23; 11. PMID: 32317979    Free PMC article.
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Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli-an Industry Perspective.
Jun Xu, Robert Saklatvala, +2 authors, Adam Procopio.
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ThymicPeptides Reverse Immune Exhaustion in Patients with Reactivated Human Alphaherpesvirus1 Infections.
Anna Hymos, Ewelina Grywalska, +3 authors, Jacek Roliński.
Int J Mol Sci, 2020 Apr 03; 21(7). PMID: 32235584    Free PMC article.
Current Insights into Combination Therapies with MAPK Inhibitors and Immune Checkpoint Blockade.
Min Hwa Shin, Jiyoung Kim, +2 authors, Kyung-Mi Lee.
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Targeted Therapies Combined With Immune Checkpoint Therapy.
Peter A Prieto, Alexandre Reuben, Zachary A Cooper, Jennifer A Wargo.
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Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA.
Pierre Tannig, Antonia Sophia Peter, +5 authors, Vladimir Temchura.
Vaccines (Basel), 2020 Jan 18; 8(1). PMID: 31947643    Free PMC article.
PD-L1 expression is a predictive biomarker for CIK cell-based immunotherapy in postoperative patients with breast cancer.
Zi-Qi Zhou, Jing-Jing Zhao, +6 authors, Jian-Chuan Xia.
J Immunother Cancer, 2019 Aug 29; 7(1). PMID: 31455411    Free PMC article.
Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab.
N Shah, J Jacob, +3 authors, H Soudy.
J Immunother Cancer, 2019 Sep 13; 7(1). PMID: 31511075    Free PMC article.
CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models.
Zhuangwei Lv, Ping Zhang, +8 authors, Yanhong Ji.
Oncoimmunology, 2020 May 05; 9(1). PMID: 32363119    Free PMC article.
Safety and Tolerability of Immune Checkpoint Inhibitors (PD-1 and PD-L1) in Cancer.
Iosune Baraibar, Ignacio Melero, Mariano Ponz-Sarvise, Eduardo Castanon.
Drug Saf, 2019 Jan 17; 42(2). PMID: 30649742
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Prognostic Value of Tumor-Infiltrating Lymphocytes Differs Depending on Lymphocyte Subsets in Esophageal Squamous Cell Carcinoma: An Updated Meta-Analysis.
Jiatao Hao, Meng Li, +5 authors, Shuai Wang.
Front Oncol, 2020 May 16; 10. PMID: 32411602    Free PMC article.
Systematic Review.
Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).
Richard S Hotchkiss, Elizabeth Colston, +12 authors, Dennis M Grasela.
Crit Care Med, 2019 Feb 13; 47(5). PMID: 30747773    Free PMC article.
Highly Cited.
Biological Difference Between Epstein-Barr Virus Positive and Negative Post-transplant Lymphoproliferative Disorders and Their Clinical Impact.
Valeria Ferla, Francesca Gaia Rossi, Maria Cecilia Goldaniga, Luca Baldini.
Front Oncol, 2020 May 28; 10. PMID: 32457824    Free PMC article.
Review.
Facing SARS-CoV-2 outbreak in immunotherapy era.
Fabrizio Citarella, Marco Russano, +4 authors, Daniele Santini.
Future Oncol, 2020 May 30; 16(20). PMID: 32468851    Free PMC article.
Review.
Effect of HIV infection and antiretroviral therapy on immune cellular functions.
Marek Korencak, Morgan Byrne, +14 authors, Hendrik Streeck.
JCI Insight, 2019 Jun 21; 4(12). PMID: 31217351    Free PMC article.
Forebrain Transcriptional Response to Transient Changes in Circulating Androgens in a Cichlid Fish.
Ana S Félix, Sara D Cardoso, António Roleira, Rui F Oliveira.
G3 (Bethesda), 2020 Apr 12; 10(6). PMID: 32276961    Free PMC article.
Activity of PD1 inhibitor therapy in advanced sarcoma: a single-center retrospective analysis.
Dionisia Quiroga, David A Liebner, +7 authors, Gabriel Tinoco.
BMC Cancer, 2020 Jun 07; 20(1). PMID: 32503455    Free PMC article.
Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells.
Shijia Wang, Guan Wang, +5 authors, Kai Cao.
Cell Biosci, 2020 Jun 09; 10. PMID: 32509271    Free PMC article.
Characteristics of Circulating CD4+ T Cell Subsets in Patients with Mycobacterium avium Complex Pulmonary Disease.
Sun Ae Han, Yousang Ko, Sung Jae Shin, Byung Woo Jhun.
J Clin Med, 2020 May 08; 9(5). PMID: 32375214    Free PMC article.
Immune Evasion by Head and Neck Cancer: Foundations for Combination Therapy.
Joshua D Horton, Hannah M Knochelmann, +2 authors, David M Neskey.
Trends Cancer, 2019 Apr 10; 5(4). PMID: 30961829    Free PMC article.
Review.
Hybrid phenotype mining method for investigating off-target protein and underlying side effects of anti-tumor immunotherapy.
Yuyu Zheng, Xiangyu Meng, +2 authors, Jingbo Xia.
BMC Med Inform Decis Mak, 2020 Jul 11; 20(Suppl 3). PMID: 32646421    Free PMC article.
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Jan A Rath, Caroline Arber.
Cells, 2020 Jun 24; 9(6). PMID: 32570906    Free PMC article.
Review.
A Review of MicroRNA in Uveal Melanoma.
Yi Fan Li, Li Dong, Yang Li, Wen Bin Wei.
Onco Targets Ther, 2020 Jul 17; 13. PMID: 32669855    Free PMC article.
Review.
High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions.
Soumaya Allouch, Ahmed Malki, +3 authors, Ala-Eddin Al Moustafa.
Front Oncol, 2020 Jul 23; 10. PMID: 32695664    Free PMC article.
Review.
T Cells Modified with CD70 as an Alternative Cellular Vaccine for Antitumor Immunity.
Sang-Eun Lee, A-Ri Shin, +2 authors, Tai-Gyu Kim.
Cancer Res Treat, 2020 Feb 18; 52(3). PMID: 32065848    Free PMC article.
SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges.
Yu Chen, Min Gao, +2 authors, Xiangjiao Meng.
J Hematol Oncol, 2020 Jul 30; 13(1). PMID: 32723363    Free PMC article.
Review.
The Ways of Isolating Neoantigen-Specific T Cells.
Qing Li, Zhen-Yu Ding.
Front Oncol, 2020 Aug 28; 10. PMID: 32850430    Free PMC article.
Review.
[Clinical Research Progress of Immune Checkpoint Inhibitors in the Treatment of 
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Benlin Huang, Yong Duan.
Zhongguo Fei Ai Za Zhi, 2019 Apr 25; 22(4). PMID: 31014443    Free PMC article.
Review.
[Progress on PD-1/PD-L1 Checkpoint Inhibitors in Lung Cancer].
Di Zhang, Jiaqi Huang, +2 authors, Qisen Guo.
Zhongguo Fei Ai Za Zhi, 2019 Jun 15; 22(6). PMID: 31196371    Free PMC article.
Review.
EBV-specific CD8 T lymphocytes and B cells during glatiramer acetate therapy in patients with MS.
Gisella Guerrera, Serena Ruggieri, +9 authors, Daniela F Angelini.
Neurol Neuroimmunol Neuroinflamm, 2020 Aug 21; 7(6). PMID: 32817203    Free PMC article.
To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.
Anna Mondino, Teresa Manzo.
Front Immunol, 2020 Sep 26; 11. PMID: 32973794    Free PMC article.
Review.
Experimental exposure of Burkholderia pseudomallei crude culture filtrate upregulates PD-1 on T lymphocytes.
Nivedita Menon, Vanitha Mariappan, +6 authors, Esaki Muthu Shankar.
Access Microbiol, 2020 Sep 26; 2(5). PMID: 32974575    Free PMC article.
Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer.
Mehmet Altan, Kelley M Kidwell, +7 authors, David L Rimm.
NPJ Breast Cancer, 2018 Dec 20; 4. PMID: 30564631    Free PMC article.
Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases.
Krupa Naran, Trishana Nundalall, Shivan Chetty, Stefan Barth.
Front Microbiol, 2019 Jan 10; 9. PMID: 30622524    Free PMC article.
Review.
Exploiting NK Cell Surveillance Pathways for Cancer Therapy.
Alexander David Barrow, Marco Colonna.
Cancers (Basel), 2019 Jan 11; 11(1). PMID: 30626155    Free PMC article.
Review.
Making cold malignant pleural effusions hot: driving novel immunotherapies.
Pranav Murthy, Chigozirim N Ekeke, +6 authors, Michael T Lotze.
Oncoimmunology, 2019 Mar 25; 8(4). PMID: 30906651    Free PMC article.
Review.
Efficacy of immunotherapy in sarcomatoid lung cancer, a case report and literature review.
Magda Palka Kotlowska, Ana Gómez Rueda, +6 authors, Pilar Garrido López.
Respir Med Case Rep, 2019 Apr 02; 26. PMID: 30931249    Free PMC article.
The optimal neoadjuvant treatment of locally advanced esophageal cancer.
Berend J van der Wilk, Ben M Eyck, +4 authors, J Jan B van Lanschot.
J Thorac Dis, 2019 May 14; 11(Suppl 5). PMID: 31080638    Free PMC article.
Review.
Peripheral blood T lymphocytes are downregulated by the PD-1/PD-L1 axis in advanced gastric cancer.
Witold Zgodzinski, Ewelina Grywalska, +6 authors, Grzegorz T Wallner.
Arch Med Sci, 2019 May 22; 15(3). PMID: 31110545    Free PMC article.
Analysis of Regulatory T Cell Subsets and Their Expression of Helios and PD-1 in Patients with Hashimoto Thyroiditis.
Yifang Hu, Lijuan Zhang, +5 authors, Dai Cui.
Int J Endocrinol, 2019 Jun 20; 2019. PMID: 31214258    Free PMC article.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent.
Katrijn Broos, Quentin Lecocq, +9 authors, Karine Breckpot.
Cancers (Basel), 2019 Jun 27; 11(6). PMID: 31234464    Free PMC article.
Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer.
Jiaojie Wei, Yang Long, +7 authors, Qin He.
Acta Pharm Sin B, 2019 Aug 07; 9(4). PMID: 31384541    Free PMC article.
A PD-L1-Based Cancer Vaccine Elicits Antitumor Immunity in a Mouse Melanoma Model.
Zhibing Lin, Yan Zhang, +4 authors, Rongxiu Li.
Mol Ther Oncolytics, 2019 Aug 07; 14. PMID: 31384666    Free PMC article.
Host Genetics of Cytomegalovirus Pathogenesis.
Efe Sezgin, Ping An, Cheryl A Winkler.
Front Genet, 2019 Aug 10; 10. PMID: 31396258    Free PMC article.
Review.
New Agents in Development for Sepsis: Any Reason for Hope?
Philippe Vignon, Pierre-François Laterre, Thomas Daix, Bruno François.
Drugs, 2020 Sep 21; 80(17). PMID: 32951149    Free PMC article.
Review.
Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
Weilei Hu, Guosheng Wang, +2 authors, Ming You.
iScience, 2020 Oct 22; 23(10). PMID: 33083746    Free PMC article.
Review.
A Novel Signature of 23 Immunity-Related Gene Pairs Is Prognostic of Cutaneous Melanoma.
Ya-Nan Xue, Yi-Nan Xue, +3 authors, Wei-Qiang Tan.
Front Immunol, 2020 Nov 17; 11. PMID: 33193373    Free PMC article.
The Mechanisms of PD-L1 Regulation in Non-Small-Cell Lung Cancer (NSCLC): Which Are the Involved Players?
Giuseppe Lamberti, Monia Sisi, +5 authors, Francesco Gelsomino.
Cancers (Basel), 2020 Oct 30; 12(11). PMID: 33114576    Free PMC article.
Review.
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis.
Pavan Brahmamdam, Shigeaki Inoue, +3 authors, Richard S Hotchkiss.
J Leukoc Biol, 2010 May 21; 88(2). PMID: 20483923    Free PMC article.
Highly Cited.
Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination.
Masaru Shimada, Shinji Yoshizaki, +2 authors, Kenji Okuda.
Vaccine, 2014 Jul 30; 32(40). PMID: 25066739    Free PMC article.
Emerging immunotherapies for bladder cancer.
Joseph W Kim, Yusuke Tomita, Jane Trepel, Andrea B Apolo.
Curr Opin Oncol, 2015 Mar 27; 27(3). PMID: 25811346    Free PMC article.
Review.
Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways.
Elisaveta Voynova, Tamer Mahmoud, +3 authors, Helen Braley-Mullen.
Immunohorizons, 2019 Jan 05; 2(1). PMID: 30607385    Free PMC article.
Prognostic value of PD-L1 expression in patients with pancreatic cancer: A PRISMA-compliant meta-analysis.
Ying Hu, Wanzhen Chen, +3 authors, Jiege Huo.
Medicine (Baltimore), 2019 Jan 18; 98(3). PMID: 30653106    Free PMC article.
Programmed death ligand 1 expression in early stage, resectable non-small cell lung cancer.
Manolo D'Arcangelo, Armida D'Incecco, +14 authors, Federico Cappuzzo.
Oncotarget, 2019 Feb 08; 10(5). PMID: 30728907    Free PMC article.
Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma.
Xin Wang, Gaochao Guo, +3 authors, Jinming Yu.
J Exp Clin Cancer Res, 2019 Feb 20; 38(1). PMID: 30777100    Free PMC article.
Highly Cited. Review.
Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.
Peng Sun, Qingyan Jin, +4 authors, Fang Guo.
J Diabetes Res, 2019 Apr 23; 2019. PMID: 31008114    Free PMC article.
PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models.
Leah A Mitchell, Kader Yagiz, +14 authors, Amy H Lin.
Oncotarget, 2019 May 02; 10(23). PMID: 31040917    Free PMC article.
IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.
Alexander Thiem, Sonja Hesbacher, +7 authors, David Schrama.
J Exp Clin Cancer Res, 2019 Sep 12; 38(1). PMID: 31506076    Free PMC article.
From the Infection to the Immunotherapy in Cervical Cancer: Can We Stop the Natural Course of the Disease?
Daniela Luvero, Salvatore Lopez, +2 authors, Roberto Angioli.
Vaccines (Basel), 2020 Oct 15; 8(4). PMID: 33050484    Free PMC article.
Review.
Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Javier Arranz-Nicolás, Miguel Martin-Salgado, +6 authors, Isabel Merida.
J Immunother Cancer, 2020 Nov 29; 8(2). PMID: 33246984    Free PMC article.
Role of PD-L1 in Gut Mucosa Tolerance and Chronic Inflammation.
Marina Chulkina, Ellen J Beswick, Irina V Pinchuk.
Int J Mol Sci, 2020 Dec 05; 21(23). PMID: 33271941    Free PMC article.
Review.
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy.
Xing Huang, Tianyu Tang, +5 authors, Tingbo Liang.
NPJ Precis Oncol, 2020 Dec 11; 4(1). PMID: 33299118    Free PMC article.
Engineering Prodrug Nanomedicine for Cancer Immunotherapy.
Bin Yang, Jing Gao, +2 authors, Haijun Yu.
Adv Sci (Weinh), 2020 Dec 12; 7(23). PMID: 33304763    Free PMC article.
Review.
Transcriptional Regulation of Cancer Immune Checkpoints: Emerging Strategies for Immunotherapy.
Simran Venkatraman, Jarek Meller, +2 authors, Somchai Chutipongtanate.
Vaccines (Basel), 2020 Dec 10; 8(4). PMID: 33291616    Free PMC article.
Review.
Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators.
Tilahun Ayane Debele, Cheng-Fa Yeh, Wen-Pin Su.
Cancers (Basel), 2020 Dec 19; 12(12). PMID: 33333816    Free PMC article.
Review.
The Role of Type I IFNs in Influenza: Antiviral Superheroes or Immunopathogenic Villains?
Wenxin Wu, Jordan P Metcalf.
J Innate Immun, 2020 Jun 22; 12(6). PMID: 32564033    Free PMC article.
Review.
Increased Expression of PD-1 and PD-L1 in Patients With Laryngotracheal Stenosis.
Ruth J Davis, Ioan Lina, +4 authors, Alexander T Hillel.
Laryngoscope, 2020 Jun 20; 131(5). PMID: 32557663    Free PMC article.
The nature of triple-negative breast cancer classification and antitumoral strategies.
Songmi Kim, Dong Hee Kim, +3 authors, Kyudong Han.
Genomics Inform, 2021 Jan 09; 18(4). PMID: 33412751    Free PMC article.
Cytomegalovirus infection as an underestimated trigger for checkpoint inhibitor-related pneumonitis in lung cancer: a retrospective study.
X Lin, T Lu, +10 authors, C Zhou.
Clin Transl Oncol, 2020 Jul 03; 23(2). PMID: 32613413
Gender-related disparities in the frequencies of PD-1 and PD-L1 positive peripheral blood T and B lymphocytes in patients with alcohol-related liver disease: a single center pilot study.
Beata Kasztelan-Szczerbinska, Katarzyna Adamczyk, +5 authors, Halina Cichoz-Lach.
PeerJ, 2021 Feb 09; 9. PMID: 33552711    Free PMC article.
Predicting Toxicity and Response to Pembrolizumab Through Germline Genomic HLA Class 1 Analysis.
Marco A J Iafolla, Cindy Yang, +11 authors, Lillian L Siu.
JNCI Cancer Spectr, 2021 Feb 09; 5(1). PMID: 33554038    Free PMC article.
Metabolic and epigenetic regulation of T-cell exhaustion.
Fabien Franco, Alison Jaccard, +2 authors, Ping-Chih Ho.
Nat Metab, 2020 Sep 23; 2(10). PMID: 32958939
Review.
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy.
Tianyu Tang, Xing Huang, +3 authors, Tingbo Liang.
Signal Transduct Target Ther, 2021 Feb 21; 6(1). PMID: 33608497    Free PMC article.
Review.
Mechanisms of resistance to chemotherapy in non-small cell lung cancer.
Hye-Young Min, Ho-Young Lee.
Arch Pharm Res, 2021 Feb 21; 44(2). PMID: 33608812
Review.
Immune checkpoint inhibition in COVID-19: risks and benefits.
Parmida Sadat Pezeshki, Nima Rezaei.
Expert Opin Biol Ther, 2021 Feb 06; 21(9). PMID: 33543652    Free PMC article.
Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms.
Arta M Monjazeb, Ziming Wang, +4 authors, William J Murphy.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578798    Free PMC article.
Non-Genetically Encoded Epitopes Are Relevant Targets in Autoimmune Diabetes.
Hai Nguyen, Perrin Guyer, Ruth A Ettinger, Eddie A James.
Biomedicines, 2021 Mar 07; 9(2). PMID: 33671312    Free PMC article.
Review.
Atezolizumab and granzyme B as immunotoxin against PD-L1 antigen; an insilico study.
Fateme Sefid, Zahra Payandeh, +7 authors, Mahnam Alaei Ardakani.
In Silico Pharmacol, 2021 Mar 09; 9(1). PMID: 33680705    Free PMC article.
Transcriptional and epigenetic regulation of PD-1 expression.
Zengde Chi, Yan Lu, +2 authors, Peiyuan Lu.
Cell Mol Life Sci, 2021 Mar 20; 78(7). PMID: 33738533
Review.
Chimeric Antigen Receptor T Cells Targeting Integrin αvβ6 Expressed on Cholangiocarcinoma Cells.
Nattaporn Phanthaphol, Chalermchai Somboonpatarakun, +6 authors, Pa-Thai Yenchitsomanus.
Front Oncol, 2021 Mar 26; 11. PMID: 33763382    Free PMC article.
Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.
Pilar Martín, Rafael Blanco-Domínguez, Raquel Sánchez-Díaz.
Cell Mol Immunol, 2020 Nov 26; 18(4). PMID: 33235388    Free PMC article.
Review.
Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review.
Aasir M Suliman, Shaza A Bek, +7 authors, Nabil E Omar.
Cancer Immunol Immunother, 2020 Oct 19; 70(4). PMID: 33070259    Free PMC article.
Review.
Cancer Vaccines, Adjuvants, and Delivery Systems.
Samantha J Paston, Victoria A Brentville, Peter Symonds, Lindy G Durrant.
Front Immunol, 2021 Apr 17; 12. PMID: 33859638    Free PMC article.
Review.
A systematic review and meta-analysis on the regulation of programmed cell death-1 on T-cells in type 2 diabetes.
Tawanda Maurice Nyambuya, Phiwayinkosi Vusi Dludla, Vuyolwethu Mxinwa, Bongani Brian Nkambule.
Medicine (Baltimore), 2021 Apr 14; 100(15). PMID: 33847657    Free PMC article.
Systematic Review.
Immunotherapy and targeted therapies in older patients with advanced melanoma; Young International Society of Geriatric Oncology review paper.
Esther Bastiaannet, Nicolò Battisti, +5 authors, Stuart Lichtman.
J Geriatr Oncol, 2018 Jul 22; 10(3). PMID: 30025821    Free PMC article.
Review.
Metabolism and immunity in breast cancer.
Deyu Zhang, Xiaojie Xu, Qinong Ye.
Front Med, 2020 Oct 20; 15(2). PMID: 33074528
Review.
Involvement of Smad7 in Inflammatory Diseases of the Gut and Colon Cancer.
Edoardo Troncone, Irene Marafini, Carmine Stolfi, Giovanni Monteleone.
Int J Mol Sci, 2021 May 01; 22(8). PMID: 33920230    Free PMC article.
Review.
Identification of PD-1 ligands: PD-L1 and PD-L2 on macrophages in lung cancer milieu by flow cytometry.
Iwona Kwiecień, Elżbieta Rutkowska, +3 authors, Joanna Domagała-Kulawik.
Transl Lung Cancer Res, 2021 May 21; 10(4). PMID: 34012784    Free PMC article.
Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.
Meihua Qiu, Yuqing Chen, Qiao Ye.
BMC Pulm Med, 2021 May 24; 21(1). PMID: 34022844    Free PMC article.
Near Infrared Photoimmunotherapy; A Review of Targets for Cancer Therapy.
Takuya Kato, Hiroaki Wakiyama, +2 authors, Hisataka Kobayashi.
Cancers (Basel), 2021 Jun 03; 13(11). PMID: 34064074    Free PMC article.
Review.
Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis.
Mayu Sun, Pengfei Gu, +7 authors, Hui Wang.
J Immunother Cancer, 2021 Jun 13; 9(6). PMID: 34117115    Free PMC article.
Programmable Unlocking Nano-Matryoshka-CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response.
Jin Yang, Zhike Li, +9 authors, Changyang Gong.
Adv Sci (Weinh), 2021 Jul 15; 8(13). PMID: 34258164    Free PMC article.
Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection.
Ryosuke Nakano, Lillian M Tran, +3 authors, Angus W Thomson.
Front Immunol, 2021 Jul 16; 12. PMID: 34262574    Free PMC article.
Review.
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.
Du-Min Go, Seung Hyun Lee, +9 authors, Dae-Yong Kim.
Cell Mol Gastroenterol Hepatol, 2021 Apr 25; 12(2). PMID: 33894424    Free PMC article.
Preoperative Immunotherapy in the Multidisciplinary Management of Oral Cavity Cancer.
Ramez Philips, Chihun Han, +4 authors, Jennifer Johnson.
Front Oncol, 2021 Jul 20; 11. PMID: 34277428    Free PMC article.
Review.
The journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences.
Amal F Alshammary, Abdulrahman M Al-Sulaiman.
Virulence, 2021 Jul 13; 12(1). PMID: 34251989    Free PMC article.
Review.
Prostasin regulates PD-L1 expression in human lung cancer cells.
Li-Mei Chen, Julius C Chai, +3 authors, Karl X Chai.
Biosci Rep, 2021 Jul 10; 41(7). PMID: 34240739    Free PMC article.
Tumor Microenvironment: Key Players in Triple Negative Breast Cancer Immunomodulation.
Hongmei Zheng, Sumit Siddharth, +2 authors, Dipali Sharma.
Cancers (Basel), 2021 Jul 21; 13(13). PMID: 34283088    Free PMC article.
Review.
Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity.
Patricia Solé, Pere Santamaria.
Front Immunol, 2021 Aug 03; 12. PMID: 34335585    Free PMC article.
Review.
CD8+ T Cell Exhaustion in Cancer.
Joseph S Dolina, Natalija Van Braeckel-Budimir, Graham D Thomas, Shahram Salek-Ardakani.
Front Immunol, 2021 Aug 07; 12. PMID: 34354714    Free PMC article.
Review.
PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective.
HaiXia Li, Chao Zheng, +3 authors, Tao Jin.
Front Cell Neurosci, 2021 Aug 13; 15. PMID: 34381337    Free PMC article.
Review.
Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.
Zhenqing Wang, Liang Chen, +7 authors, Jian Dong.
J Nanobiotechnology, 2021 Aug 14; 19(1). PMID: 34384429    Free PMC article.
High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence.
Ryo Muranushi, Kenichiro Araki, +16 authors, Ken Shirabe.
Cancer Sci, 2021 Jun 04; 112(8). PMID: 34080242    Free PMC article.
How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer.
Jacob Stultz, Lawrence Fong.
Prostate Cancer Prostatic Dis, 2021 Apr 07; 24(3). PMID: 33820953    Free PMC article.
Review.
Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy.
Juwon Lee, Youngjin Han, +7 authors, Yong Sang Song.
Biomolecules, 2021 Aug 28; 11(8). PMID: 34439774    Free PMC article.
Review.
Role of the Immune System Elements in Pulmonary Arterial Hypertension.
Michał Tomaszewski, Dominika Bębnowska, +4 authors, Ewelina Grywalska.
J Clin Med, 2021 Aug 28; 10(16). PMID: 34442052    Free PMC article.
Review.
Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA.
Kaya E Witte, Jesco Pfitzenmaier, +12 authors, Christian Kaltschmidt.
Int J Mol Sci, 2021 Aug 28; 22(16). PMID: 34445612    Free PMC article.
Real-world safety and effectiveness of nivolumab for recurrent or metastatic head and neck cancer in Japan: a post-marketing surveillance.
Makoto Tahara, Naomi Kiyota, +3 authors, Ryuichi Hayashi.
Int J Clin Oncol, 2021 Jun 11; 26(9). PMID: 34110532    Free PMC article.
Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft.
Duy Tri Le, Tridu R Huynh, +7 authors, Silke Paust.
JCI Insight, 2021 Jun 04; 6(13). PMID: 34081628    Free PMC article.
The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy.
Wenxiao Jiang, Shuya Pan, +2 authors, Xueqiong Zhu.
Mol Cancer, 2021 Sep 10; 20(1). PMID: 34496886    Free PMC article.
Review.
Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.
Harry H Matundan, Ujjaldeep Jaggi, +2 authors, Homayon Ghiasi.
mBio, 2021 Jul 21; 12(4). PMID: 34281386    Free PMC article.
Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the PD-1 Pathway.
Shankargouda Patil, Mohammed E Sayed, +11 authors, A Thirumal Raj.
Int J Mol Sci, 2021 Sep 11; 22(17). PMID: 34502071    Free PMC article.
High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis.
Philippa Li, Ji Yuan, +7 authors, Zenggang Pan.
Front Oncol, 2021 Sep 17; 11. PMID: 34527580    Free PMC article.
Granulocytic myeloid-derived suppressor cells inhibit T follicular helper cells during experimental Schistosoma japonicum infection.
Yumei Zhang, Yulong Wu, +4 authors, Jianping Cao.
Parasit Vectors, 2021 Sep 28; 14(1). PMID: 34565440    Free PMC article.
Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma.
Tao Yang, Yuki Mochida, +6 authors, Kazunori Kataoka.
Nat Biomed Eng, 2021 Oct 13; 5(11). PMID: 34635819
The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment.
Nadia Bolandi, Afshin Derakhshani, +7 authors, Behzad Baradaran.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639059    Free PMC article.
Review.
Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma.
Kelsey Maddison, Moira C Graves, +4 authors, Paul A Tooney.
Oncotarget, 2021 Oct 23; 12(21). PMID: 34676050    Free PMC article.
Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.
Yu-Chao Zhu, Hany M Elsheikha, +4 authors, Jia Chen.
J Immunother Cancer, 2021 Nov 03; 9(11). PMID: 34725213    Free PMC article.
New Insights into the Role of PD-1 and Its Ligands in Allergic Disease.
Miguel Angel Galván Morales, Josaphat Miguel Montero-Vargas, Juan Carlos Vizuet-de-Rueda, Luis M Teran.
Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34769327    Free PMC article.
Review.
EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses.
Dinoop Ravindran Menon, Yang Li, +5 authors, Mayumi Fujita.
Pharmaceuticals (Basel), 2021 Nov 28; 14(11). PMID: 34832863    Free PMC article.
The Potential Advantage of Targeting Both PD-L1/PD-L2/PD-1 and IL-10-IL-10R Pathways in Acute Myeloid Leukemia.
Laura Jimbu, Oana Mesaros, +5 authors, Mihnea Zdrenghea.
Pharmaceuticals (Basel), 2021 Nov 28; 14(11). PMID: 34832887    Free PMC article.
Review.
Wnt-β-Catenin Signaling in Human Dendritic Cells Mediates Regulatory T-Cell Responses to Fungi via the PD-L1 Pathway.
Anupama Karnam, Srinivasa Reddy Bonam, +3 authors, Jagadeesh Bayry.
mBio, 2021 Nov 17; 12(6). PMID: 34781737    Free PMC article.
Deep phenotyping of T cell populations under long-term treatment of tacrolimus and rapamycin in patients receiving renal transplantations by mass cytometry.
Yiyang Li, Huimin An, +6 authors, Xianting Ding.
Clin Transl Med, 2021 Nov 30; 11(11). PMID: 34841735    Free PMC article.
Advances in molecular mechanisms of interaction between Mycobacterium tuberculosis and lung cancer: a narrative review.
Kunlong Xiong, Wenwen Sun, Yayi He, Lin Fan.
Transl Lung Cancer Res, 2021 Dec 04; 10(10). PMID: 34858788    Free PMC article.
Review.
Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes.
Katelyn Mika, Mirna Marinić, +3 authors, Vincent J Lynch.
Elife, 2021 Oct 09; 10. PMID: 34623259    Free PMC article.
Emerging Role of PD-1/PD-L1 Inhibitors in Chronic Liver Diseases.
Vishakha Singh, Amit Khurana, +3 authors, Ralf Weiskirchen.
Front Pharmacol, 2022 Jan 11; 12. PMID: 35002724    Free PMC article.
Review.
miR-4759 suppresses breast cancer through immune checkpoint blockade.
You-Zhe Lin, Shu-Hsuan Liu, +8 authors, Shao-Chun Wang.
Comput Struct Biotechnol J, 2022 Jan 14; 20. PMID: 35024096    Free PMC article.
Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women.
Yanyuan Wu, Pranabananda Dutta, +2 authors, Jaydutt V Vadgama.
J Clin Med, 2022 Jan 22; 11(2). PMID: 35053979    Free PMC article.
The Regulatory Microenvironment in Feathers of Chickens Infected with Very Virulent Marek's Disease Virus.
Jegarubee Bavananthasivam, Nadiyah Alqazlan, +4 authors, Shayan Sharif.
Viruses, 2022 Jan 23; 14(1). PMID: 35062316    Free PMC article.
Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells.
Nadine Honke, Torsten Lowin, +5 authors, Georg Pongratz.
PLoS Biol, 2022 Jan 25; 20(1). PMID: 35073310    Free PMC article.
Vitamin D can reduce severity in COVID-19 through regulation of PD-L1.
Hatice Aygun.
Naunyn Schmiedebergs Arch Pharmacol, 2022 Feb 01; 395(4). PMID: 35099571    Free PMC article.
Review.
Immunotherapy as a targeted therapy in non-small cell lung cancer.
Danilo Rocco, Luigi Della Gravara, +2 authors, Ciro Battiloro.
Transl Cancer Res, 2019 Jan 01; 8(Suppl 1). PMID: 35117066    Free PMC article.
Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics.
Hirohito Yamaguchi, Jung-Mao Hsu, Wen-Hao Yang, Mien-Chie Hung.
Nat Rev Clin Oncol, 2022 Feb 09; 19(5). PMID: 35132224
Review.
Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.
Zhuochao Liu, Junxiang Wen, +3 authors, Weibin Zhang.
Cancer Sci, 2021 Dec 21; 113(2). PMID: 34927311    Free PMC article.
Inborn Errors of Immunity and Their Phenocopies: CTLA4 and PD-1.
Yuwei Hao, Matthew C Cook.
Front Immunol, 2022 Feb 15; 12. PMID: 35154081    Free PMC article.
Review.
Oral Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: Salivary Gland Dysfunction and Mucosal Diseases.
Yoshiaki Yura, Masakazu Hamada.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35159059    Free PMC article.
Review.
Immunotherapeutic Approaches for the Treatment of HPV-Associated (Pre-)Cancer of the Cervix, Vulva and Penis.
Tynisha S Rafael, Jossie Rotman, +5 authors, Ekaterina S Jordanova.
J Clin Med, 2022 Feb 26; 11(4). PMID: 35207374    Free PMC article.
Review.
PD-L1 Expression Correlated with Clinicopathological Factors and Akt/Stat3 Pathway in Oral SCC.
Dong-Ho Geum, Dae-Seok Hwang, +4 authors, Uk-Kyu Kim.
Life (Basel), 2022 Feb 26; 12(2). PMID: 35207525    Free PMC article.
Natural killer cell-related gene signature predicts malignancy of glioma and the survival of patients.
Chenglong Li, Fangkun Liu, +2 authors, Yu Zeng.
BMC Cancer, 2022 Mar 04; 22(1). PMID: 35236310    Free PMC article.
Diagnostic Performance of PD-L1 versus PD-1 Expression in Circulating CD20 Cells in Diffuse Large B-Cell Lymphoma.
Manal Mohamed Saber.
Antibodies (Basel), 2022 Mar 01; 11(1). PMID: 35225873    Free PMC article.
Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation.
Mengling Wu, Qianrui Huang, +4 authors, Yong Xia.
J Hematol Oncol, 2022 Mar 14; 15(1). PMID: 35279217    Free PMC article.
Review.
Integrative Analysis of Multi-Omics Data-Identified Key Genes With KLRC3 as the Core in a Gene Regulatory Network Related to Immune Phenotypes in Lung Adenocarcinoma.
Kai Mao, Yunxi Zhao, +4 authors, Qun Xue.
Front Genet, 2022 Apr 19; 13. PMID: 35432443    Free PMC article.
A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice.
Pauline Le Vu, Jayakumar Vadakekolathu, +7 authors, Stéphanie E McArdle.
Cancers (Basel), 2022 Apr 24; 14(8). PMID: 35454873    Free PMC article.
Platycodon grandiflorum Triggers Antitumor Immunity by Restricting PD-1 Expression of CD8+ T Cells in Local Tumor Microenvironment.
Ruijie Yang, Tianli Pei, +6 authors, Chao Huang.
Front Pharmacol, 2022 May 03; 13. PMID: 35496272    Free PMC article.