Review
. 2007 May; 7(1):49-55.
doi: 10.1007/s11882-007-0030-2.

Immunology of anaphylaxis: lessons from murine models

M Luisa Baeza 1 José Manuel Zubeldia  
Affiliations
  • PMID: 17504661
  •     54 References
  •     2 citations

Abstract

The use of animal models is increasing, and mice are suitable animals to use in exploring systemic anaphylaxis based on the similarity between human and mouse immune systems. Two anaphylaxis pathways have been characterized in mice, which may help in understanding some of the discrepancies found in humans. In addition, cytokine studies are raising new concepts that may put together some of the puzzling mechanisms described in this disease. Finally, the study of the mechanisms that parasitic infections use to evade the human immune system and the scene in which a parasite induces clinical anaphylaxis are opening new insights in the immunology pathways and new strategies to fight against this exclusive disease.

Mast cells are required for experimental oral allergen-induced diarrhea.
Eric B Brandt, Richard T Strait, +6 authors, Marc E Rothenberg.
J Clin Invest, 2003 Dec 09; 112(11). PMID: 14660743    Free PMC article.
Highly Cited.
Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-beta.
Atsushi Okamoto, Tatsuyoshi Kawamura, +4 authors, Atsuhito Nakao.
Int Immunol, 2005 Apr 20; 17(6). PMID: 15837712
Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.
D Dombrowicz, V Flamand, +3 authors, J P Kinet.
J Clin Invest, 1997 Mar 01; 99(5). PMID: 9062349    Free PMC article.
Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model.
Xiu-Min Li, Kamal Srivastava, +3 authors, Hugh A Sampson.
J Immunol, 2003 Mar 11; 170(6). PMID: 12626588
Anisakis simplex allergy: a murine model of anaphylaxis induced by parasitic proteins displays a mixed Th1/Th2 pattern.
M L Baeza, L Conejero, +5 authors, J M Zubeldia.
Clin Exp Immunol, 2005 Nov 22; 142(3). PMID: 16297154    Free PMC article.
Comparison of different monoclonal antibodies against immunosuppressive proteins of Ascaris suum.
T M Oshiro, A Rafael, +2 authors, M F Macedo-Soares.
Braz J Med Biol Res, 2004 Feb 06; 37(2). PMID: 14762577
Food allergy animal models: an overview.
Ricki M Helm.
Ann N Y Acad Sci, 2002 May 23; 964. PMID: 12023201
Review.
CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization.
Femke van Wijk, Sanne Hoeks, +5 authors, Raymond Pieters.
J Immunol, 2004 Dec 22; 174(1). PMID: 15611239
Production and characterization of a monoclonal antibody against an Ascaris suum allergenic component.
R R Pires, T M Oshiro, +2 authors, M F Macedo-Soares.
Braz J Med Biol Res, 2001 Jul 27; 34(8). PMID: 11471042
A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses.
X M Li, D Serebrisky, +7 authors, H A Sampson.
J Allergy Clin Immunol, 2000 Jul 11; 106(1 Pt 1). PMID: 10887318
A murine model of IgE-mediated cow's milk hypersensitivity.
X M Li, B H Schofield, +2 authors, H A Sampson.
J Allergy Clin Immunol, 1999 Feb 09; 103(2 Pt 1). PMID: 9949309
Molecular mechanisms of anaphylaxis: lessons from studies with murine models.
Fred D Finkelman, Marc E Rothenberg, +2 authors, Richard T Strait.
J Allergy Clin Immunol, 2005 Mar 09; 115(3). PMID: 15753886
Review.
Oral tolerance.
K M Smith, A D Eaton, L M Finlayson, P Garside.
Am J Respir Crit Care Med, 2000 Oct 13; 162(4 Pt 2). PMID: 11029390
Review.
The germless theory of allergic disease: revisiting the hygiene hypothesis.
M Wills-Karp, J Santeliz, C L Karp.
Nat Rev Immunol, 2002 Mar 22; 1(1). PMID: 11905816
Highly Cited. Review.
Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice.
C Godfraind, J Louahed, +4 authors, J C Renauld.
J Immunol, 1998 Apr 29; 160(8). PMID: 9558107
Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity.
Anthony A Horner, Kenji Takabayashi, +8 authors, Eyal Raz.
J Allergy Clin Immunol, 2002 Sep 05; 110(3). PMID: 12209088
Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy.
Christophe P Frossard, Conrad Hauser, Philippe A Eigenmann.
J Allergy Clin Immunol, 2004 Aug 19; 114(2). PMID: 15316519
Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes.
C Petit-Frere, B Dugas, P Braquet, J M Mencia-Huerta.
Immunology, 1993 May 01; 79(1). PMID: 8509135    Free PMC article.
Peripheral deletion of antigen-reactive T cells in oral tolerance.
Y Chen, J Inobe, +3 authors, H L Weiner.
Nature, 1995 Jul 13; 376(6536). PMID: 7603570
Highly Cited.
Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial.
Jean-Marc Fellrath, Alexander Kettner, +5 authors, François Spertini.
J Allergy Clin Immunol, 2003 Apr 22; 111(4). PMID: 12704369
Pathways of anaphylaxis in the mouse.
Richard T Strait, Suzanne C Morris, +2 authors, Fred D Finkelman.
J Allergy Clin Immunol, 2002 Apr 10; 109(4). PMID: 11941316
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
Richard T Strait, Suzanne C Morris, Fred D Finkelman.
J Clin Invest, 2006 Feb 25; 116(3). PMID: 16498503    Free PMC article.
An enteric helminth infection protects against an allergic response to dietary antigen.
Mohamed Elfatih H Bashir, Peter Andersen, +2 authors, Cathryn Nagler-Anderson.
J Immunol, 2002 Sep 10; 169(6). PMID: 12218148
Inhibition of IgE-induced activation of human mast cells by IL-10.
B Royer, S Varadaradjalou, +3 authors, M Arock.
Clin Exp Allergy, 2001 Jun 26; 31(5). PMID: 11422128
The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy.
Kamal D Srivastava, Jacob D Kattan, +6 authors, Xiu-Min Li.
J Allergy Clin Immunol, 2005 Jan 08; 115(1). PMID: 15637565
Anti-granulocyte antibody suppression of active and passive anaphylactic shock in WBB6F1-W/Wv mice.
S Kimura, M Nagata, +2 authors, M Harada.
Cell Mol Life Sci, 1997 Aug 01; 53(8). PMID: 9351469
Anisakis simplex-sensitized patients: should fish be excluded from their diet?
M T Gracia-Bara, V Matheu, +6 authors, M L Baeza.
Ann Allergy Asthma Immunol, 2001 Jun 29; 86(6). PMID: 11428742
Recurrent anaphylaxis caused by Anisakis simplex parasitizing fish.
M T Audicana, L Fernández de Corres, +3 authors, M D del Pozo.
J Allergy Clin Immunol, 1995 Oct 01; 96(4). PMID: 7560669
DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice.
A A Horner, M D Nguyen, +3 authors, E Raz.
J Allergy Clin Immunol, 2000 Aug 10; 106(2). PMID: 10932080
Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG.
F D Finkelman, I Scher, +3 authors, E S Metcalf.
J Immunol, 1982 Aug 01; 129(2). PMID: 6177773
Asthma: an epidemic of dysregulated immunity.
Dale T Umetsu, Jennifer J McIntire, +2 authors, Rosemarie H DeKruyff.
Nat Immunol, 2002 Jul 30; 3(8). PMID: 12145657
Highly Cited. Review.
Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice.
Vivian Morafo, Kamal Srivastava, +4 authors, AndXiu-Min Li.
J Allergy Clin Immunol, 2003 May 14; 111(5). PMID: 12743580
Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios.
Petra A Wachholz, Kayhan T Nouri-Aria, +4 authors, Stephen R Durham.
Immunology, 2002 Feb 19; 105(1). PMID: 11849315    Free PMC article.
A novel model of sensitization and oral tolerance to peanut protein.
Jessica Strid, Melanie Thomson, +2 authors, Stephan Strobel.
Immunology, 2004 Oct 27; 113(3). PMID: 15500615    Free PMC article.
Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI.
B Wang, A Rieger, +5 authors, G Stingl.
J Exp Med, 1992 May 01; 175(5). PMID: 1533243    Free PMC article.
Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene.
D Dombrowicz, V Flamand, +2 authors, J P Kinet.
Cell, 1993 Dec 03; 75(5). PMID: 8252632
Highly Cited.
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.
W P Fung-Leung, J De Sousa-Hitzler, +7 authors, C Y Lau.
J Exp Med, 1996 Jan 01; 183(1). PMID: 8551243    Free PMC article.
Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
Hugh A Sampson, Anne Muñoz-Furlong, +23 authors, Wyatt W Decker.
J Allergy Clin Immunol, 2006 Feb 08; 117(2). PMID: 16461139
Highly Cited.
High-affinity IgE receptor on eosinophils is involved in defence against parasites.
A S Gounni, B Lamkhioued, +5 authors, M Capron.
Nature, 1994 Jan 13; 367(6459). PMID: 8114916
Highly Cited.
IL-4 exacerbates anaphylaxis.
Richard T Strait, Suzanne C Morris, +2 authors, Fred D Finkelman.
J Immunol, 2003 Mar 21; 170(7). PMID: 12646651
Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses.
T Takeishi, T R Martin, +2 authors, S J Galli.
J Clin Invest, 1991 Aug 01; 88(2). PMID: 1864969    Free PMC article.
Allergy, parasites, and the hygiene hypothesis.
Maria Yazdanbakhsh, Peter G Kremsner, Ronald van Ree.
Science, 2002 Apr 20; 296(5567). PMID: 11964470
Highly Cited. Review.
A review on Fc epsilon RI on human epidermal Langerhans cells.
K Ochiai, B Wang, +6 authors, H Tomioka.
Int Arch Allergy Immunol, 1994 Jan 01; 104 Suppl 1(1). PMID: 8156009
Review.
Immunologic influences on allergy and the TH1/TH2 balance.
Sergio Romagnani.
J Allergy Clin Immunol, 2004 Feb 06; 113(3). PMID: 14758340
Review.
Anti-inflammatory activity of PAS-1, a protein component of Ascaris suum.
T M Oshiro, M S Macedo, M F Macedo-Soares.
Inflamm Res, 2005 Feb 22; 54(1). PMID: 15723200
Anaphylactic and non-anaphylactic murine IgG1 differ in their ability to bind to mast cells: relevance of proper glycosylation of the molecule.
Eliana L Faquim-Mauro, Jacqueline F Jacysyn, Mahasti S Macedo.
Immunobiology, 2003 Jun 05; 207(3). PMID: 12777058
Peanut- and cow's milk-specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin.
K Adel-Patient, H Bernard, +2 authors, J-M Wal.
Allergy, 2005 Apr 09; 60(5). PMID: 15813812
Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells.
I Bellinghausen, U Brand, +3 authors, J Saloga.
J Allergy Clin Immunol, 2001 Aug 10; 108(2). PMID: 11496241
Oral carrageenan induces antigen-dependent oral tolerance: prevention of anaphylaxis and induction of lymphocyte anergy in a murine model of food allergy.
C P Frossard, C Hauser, P A Eigenmann.
Pediatr Res, 2001 Mar 03; 49(3). PMID: 11228270
Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice.
Tamara Matysiak-Budnik, Guillaume van Niel, +5 authors, Martine Heyman.
Infect Immun, 2003 Aug 23; 71(9). PMID: 12933867    Free PMC article.
Quantitative assessment of immediate cutaneous hypersensitivity in a model of genetic predisposition to atopy.
A Daser, N Bätjer, +4 authors, H Renz.
Int Arch Allergy Immunol, 1999 Feb 27; 117(4). PMID: 10048895
IL-9 promotes but is not necessary for systemic anaphylaxis.
Laurent Knoops, Jamila Louahed, Jacques Van Snick, Jean-Christophe Renauld.
J Immunol, 2005 Jun 24; 175(1). PMID: 15972666
Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases.
K D Yang, C-A Liu, +4 authors, C-L Wang.
Clin Exp Allergy, 2004 Jan 15; 34(1). PMID: 14720259
Helminth infection protects mice from anaphylaxis via IL-10-producing B cells.
Niamh E Mangan, Rosemary E Fallon, +3 authors, Padraic G Fallon.
J Immunol, 2004 Nov 06; 173(10). PMID: 15528374
Understanding the mechanisms of anaphylaxis.
Richard D Peavy, Dean D Metcalfe.
Curr Opin Allergy Clin Immunol, 2008 Jul 04; 8(4). PMID: 18596587    Free PMC article.
Review.
Development of a BALB/c mouse model for food allergy: comparison of allergy-related responses to peanut agglutinin, β-lactoglobulin and potato acid phosphatase.
Chen Chen, Lu Lianhua, +2 authors, Jia Xudong.
Toxicol Res (Camb), 2017 Jan 16; 6(2). PMID: 30090496    Free PMC article.