. 2008 Mar; 8(4):247-58.
doi: 10.1038/nri2274.

T-cell quality in memory and protection: implications for vaccine design

Robert A Seder 1 Patricia A Darrah  Mario Roederer  
  • PMID: 18323851
  •     761 citations


T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.

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K Kai McKinstry, Tara M Strutt, Susan L Swain.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636812    Free PMC article.
TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.
Jun Du, Zhiyuan Wu, +4 authors, Chunfeng Qu.
Vaccine, 2010 Jul 20; 28(38). PMID: 20637759    Free PMC article.
Single-shot immunization with recombinant adenovirus encoding vaccinia virus glycoprotein A27L is protective against a virulent respiratory poxvirus infection.
Rajeev Rudraraju, Alistair J Ramsay.
Vaccine, 2010 Jul 24; 28(31). PMID: 20653083    Free PMC article.
Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates.
Thomas W Geisbert, Michael Bailey, +8 authors, Nancy J Sullivan.
J Virol, 2010 Jul 28; 84(19). PMID: 20660192    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Monofunctional and polyfunctional CD8+ T cell responses to human herpesvirus 8 lytic and latency proteins.
Lauren Lepone, Giovanna Rappocciolo, +4 authors, Charles R Rinaldo.
Clin Vaccine Immunol, 2010 Aug 20; 17(10). PMID: 20719985    Free PMC article.
Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool.
Chulwoo Kim, Matthew A Williams.
Immunology, 2010 Aug 27; 131(3). PMID: 20738422    Free PMC article.
Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1.
Anju Singh, Anna Jatzek, +3 authors, M Suresh.
Mol Cell Biol, 2010 Sep 02; 30(21). PMID: 20805358    Free PMC article.
The impact of ex vivo clinical grade activation protocols on human T-cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy.
Paul C Tumeh, Richard C Koya, +4 authors, Antoni Ribas.
J Immunother, 2010 Sep 16; 33(8). PMID: 20842061    Free PMC article.
IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
John S Yi, Jennifer T Ingram, Allan J Zajac.
J Immunol, 2010 Sep 17; 185(8). PMID: 20844201    Free PMC article.
Selection Sampling from Large Data Sets for Targeted Inference in Mixture Modeling.
Ioanna Manolopoulou, Cliburn Chan, Mike West.
Bayesian Anal, 2010 Sep 25; 5(3). PMID: 20865145    Free PMC article.
T(H)2 heterogeneity: Does function follow form?
Calman Prussin, Yuzhi Yin, Bhaskar Upadhyaya.
J Allergy Clin Immunol, 2010 Oct 19; 126(6). PMID: 20951419    Free PMC article.
Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.
Jürgen Kuball, Karin de Boer, +11 authors, Matthias Theobald.
Cancer Immunol Immunother, 2010 Oct 22; 60(2). PMID: 20963411    Free PMC article.
Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease.
Lerisa Govender, Brian Abel, +10 authors, Willem A Hanekom.
Vaccine, 2010 Oct 27; 29(1). PMID: 20974305    Free PMC article.
Designing vaccines based on biology of human dendritic cell subsets.
Karolina Palucka, Jacques Banchereau, Ira Mellman.
Immunity, 2010 Oct 30; 33(4). PMID: 21029958    Free PMC article.
Highly Cited. Review.
Adaptive immunity against Leishmania nucleoside hydrolase maps its c-terminal domain as the target of the CD4+ T cell-driven protective response.
Dirlei Nico, Carla Claser, +5 authors, Clarisa B Palatnik-de-Sousa.
PLoS Negl Trop Dis, 2010 Nov 19; 4(11). PMID: 21085470    Free PMC article.
Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.
Dennis Christensen, Thomas Lindenstrøm, +2 authors, Else Marie Agger.
PLoS One, 2010 Dec 03; 5(11). PMID: 21124731    Free PMC article.
Effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on CD4+ T cell activation by dendritic cells.
Cyril Le Nouën, Philippa Hillyer, +6 authors, Ursula J Buchholz.
PLoS One, 2010 Dec 03; 5(11). PMID: 21124776    Free PMC article.
Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.
Robin Stephens, Jean Langhorne.
PLoS Pathog, 2010 Dec 03; 6(11). PMID: 21124875    Free PMC article.
Genetic immunization in the lung induces potent local and systemic immune responses.
Kaimei Song, Diane L Bolton, +15 authors, Srinivas S Rao.
Proc Natl Acad Sci U S A, 2010 Dec 08; 107(51). PMID: 21135247    Free PMC article.
Immunotherapy coming of age: what will it take to make it standard of care for glioblastoma?
Amy B Heimberger, John H Sampson.
Neuro Oncol, 2010 Dec 15; 13(1). PMID: 21149252    Free PMC article.
Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis.
Rosalyn Casey, Deena Blumenkrantz, +8 authors, Ajit Lalvani.
PLoS One, 2010 Dec 24; 5(12). PMID: 21179481    Free PMC article.
Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination.
Mathias Streitz, Stephan Fuhrmann, +6 authors, Florian Kern.
J Infect Dis, 2010 Dec 28; 203(3). PMID: 21186260    Free PMC article.
Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses.
Byoung-Shik Shim, Sung-Moo Park, +10 authors, Cheol-Heui Yun.
BMC Immunol, 2011 Jan 05; 11. PMID: 21194475    Free PMC article.
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
Eric Tran, Julie S Nielsen, +6 authors, Brad H Nelson.
PLoS One, 2011 Jan 05; 5(12). PMID: 21203522    Free PMC article.
CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.
Kristin Scheible, Gang Zhang, +5 authors, David J Topham.
Vaccine, 2011 Jan 08; 29(11). PMID: 21211588    Free PMC article.
Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis.
L D Snyder, R Medinas, +4 authors, K J Weinhold.
Am J Transplant, 2011 Jan 12; 11(3). PMID: 21219584    Free PMC article.
Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.
L Jean Patterson, Mara Daltabuit-Test, +16 authors, Marjorie Robert-Guroff.
Virology, 2011 Jan 18; 411(1). PMID: 21237474    Free PMC article.
Stem cell-based approaches to treating HIV infection.
Scott G Kitchen, Jerome A Zack.
Curr Opin HIV AIDS, 2011 Jan 19; 6(1). PMID: 21242896    Free PMC article.
Identification of human T-cell responses to Mycobacterium tuberculosis resuscitation-promoting factors in long-term latently infected individuals.
Susanna Commandeur, Krista E van Meijgaarden, +7 authors, Tom H M Ottenhoff.
Clin Vaccine Immunol, 2011 Jan 21; 18(4). PMID: 21248154    Free PMC article.
Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.
Michel DuPage, Ann F Cheung, +6 authors, Tyler Jacks.
Cancer Cell, 2011 Jan 22; 19(1). PMID: 21251614    Free PMC article.
Highly Cited.
SPICE: exploration and analysis of post-cytometric complex multivariate datasets.
Mario Roederer, Joshua L Nozzi, Martha C Nason.
Cytometry A, 2011 Jan 26; 79(2). PMID: 21265010    Free PMC article.
Highly Cited.
Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques.
Wen-Hsuan Lin, Diane E Griffin, +10 authors, Scott Winston.
Proc Natl Acad Sci U S A, 2011 Feb 02; 108(7). PMID: 21282608    Free PMC article.
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
Christina F Thobakgale, Hendrik Streeck, +9 authors, Thumbi Ndung'u.
AIDS Res Hum Retroviruses, 2011 Feb 04; 27(9). PMID: 21288139    Free PMC article.
Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation.
Joshua T Mattila, Collin R Diedrich, +2 authors, JoAnne L Flynn.
J Immunol, 2011 Feb 15; 186(6). PMID: 21317393    Free PMC article.
Immunologic basis for revaccination of HIV-infected children receiving HAART.
Kaitlin Rainwater-Lovett, William J Moss.
Future Virol, 2011 Feb 23; 6(1). PMID: 21339832    Free PMC article.
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.
A P Turner, V O Shaffer, +7 authors, C P Larsen.
Am J Transplant, 2011 Feb 24; 11(3). PMID: 21342450    Free PMC article.
A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses.
Daniela Santoro Rosa, Susan Pereira Ribeiro, +4 authors, Edecio Cunha-Neto.
PLoS One, 2011 Feb 25; 6(2). PMID: 21347287    Free PMC article.
CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells.
Brian M Olson, Douglas G McNeel.
Cancer Immunol Immunother, 2011 Feb 26; 60(6). PMID: 21350948    Free PMC article.
Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults.
Kondwani C Jambo, Enoch Sepako, +5 authors, Stephen B Gordon.
Thorax, 2011 Mar 02; 66(5). PMID: 21357587    Free PMC article.
Hallmarks of CD4 T cell immunity against influenza.
K K McKinstry, T M Strutt, S L Swain.
J Intern Med, 2011 Mar 03; 269(5). PMID: 21362069    Free PMC article.
T-cell immune responses against Env from CRF12_BF and subtype B HIV-1 show high clade-specificity that can be overridden by multiclade immunizations.
Daniela C Mónaco, Ana M Rodríguez, +8 authors, M Magdalena Gherardi.
PLoS One, 2011 Mar 03; 6(2). PMID: 21364754    Free PMC article.
Development of new vaccines and drugs for TB: limitations and potential strategic errors.
Ian M Orme.
Future Microbiol, 2011 Mar 04; 6(2). PMID: 21366417    Free PMC article.
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.
Takuya Yamamoto, David A Price, +10 authors, Richard A Koup.
Blood, 2011 Mar 15; 117(18). PMID: 21398582    Free PMC article.
Highly Cited.
Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections.
Simon Metenou, Benoit Dembele, +12 authors, Thomas B Nutman.
J Immunol, 2011 Mar 18; 186(8). PMID: 21411732    Free PMC article.
The augmented neutrophil respiratory burst in response to Escherichia coli is reduced in liver cirrhosis during infection.
T Bruns, J Peter, +2 authors, A Stallmach.
Clin Exp Immunol, 2011 Mar 19; 164(3). PMID: 21413941    Free PMC article.
Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines.
Lukas Flatz, Rahul Roychoudhuri, +8 authors, Gary J Nabel.
Proc Natl Acad Sci U S A, 2011 Mar 23; 108(14). PMID: 21422297    Free PMC article.
HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo.
Aude G Chapuis, Corey Casper, +9 authors, Philip D Greenberg.
Blood, 2011 Mar 23; 117(20). PMID: 21422474    Free PMC article.
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection.
Kerry A Millington, Sarah M Fortune, +5 authors, Ajit Lalvani.
Proc Natl Acad Sci U S A, 2011 Mar 24; 108(14). PMID: 21427227    Free PMC article.
Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.
Mareike Meythaler, Zichun Wang, +5 authors, Amitinder Kaur.
J Immunol, 2011 Mar 29; 186(9). PMID: 21441446    Free PMC article.
Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors.
Cristina Cellerai, Alexandre Harari, +11 authors, Sabine Kinloch-de Loes.
PLoS One, 2011 Apr 13; 6(4). PMID: 21483676    Free PMC article.
Respiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the human T lymphocyte response.
Shirin Munir, Philippa Hillyer, +4 authors, Alexander Bukreyev.
PLoS Pathog, 2011 May 03; 7(4). PMID: 21533073    Free PMC article.
Latency antigen α-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines.
Bappaditya Dey, Ruchi Jain, +4 authors, Anil K Tyagi.
PLoS One, 2011 May 03; 6(4). PMID: 21533158    Free PMC article.
A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.
Chao Ma, Rong Fan, +9 authors, James R Heath.
Nat Med, 2011 May 24; 17(6). PMID: 21602800    Free PMC article.
Highly Cited.
Tuberculosis vaccines in clinical trials.
Rosalind Rowland, Helen McShane.
Expert Rev Vaccines, 2011 May 25; 10(5). PMID: 21604985    Free PMC article.
Recombinant HBHA boosting effect on BCG-induced immunity against Mycobacterium tuberculosis infection.
G G Guerrero, C Locht.
Clin Dev Immunol, 2011 Jun 08; 2011. PMID: 21647410    Free PMC article.
Cytomegalovirus viral load and virus-specific immune reconstitution after peripheral blood stem cell versus bone marrow transplantation.
Abraham Guerrero, Stanley R Riddell, +8 authors, Michael Boeckh.
Biol Blood Marrow Transplant, 2011 Jun 15; 18(1). PMID: 21664286    Free PMC article.
Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.
Gabriel Pedersen, Diane Major, +3 authors, Rebecca J Cox.
Influenza Other Respir Viruses, 2011 Jun 15; 5(6). PMID: 21668670    Free PMC article.
Vaccines for gonorrhea: can we rise to the challenge?
Weiyan Zhu, Ching-Ju Chen, +3 authors, P Frederick Sparling.
Front Microbiol, 2011 Jun 21; 2. PMID: 21687431    Free PMC article.
Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion.
Joanne M Lumsden, Sathit Pichyangkul, +13 authors, Anjali Yadava.
Infect Immun, 2011 Jun 22; 79(9). PMID: 21690242    Free PMC article.
Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection.
Shahram Salek-Ardakani, Magdalini Moutaftsi, Alessandro Sette, Michael Croft.
J Virol, 2011 Jul 01; 85(17). PMID: 21715499    Free PMC article.
Latent tuberculosis: what the host "sees"?
Hannah P Gideon, JoAnne L Flynn.
Immunol Res, 2011 Jul 01; 50(2-3). PMID: 21717066    Free PMC article.
Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge.
Daryan A Kaveh, Véronique S Bachy, R Glyn Hewinson, Philip J Hogarth.
PLoS One, 2011 Jul 02; 6(6). PMID: 21720558    Free PMC article.
Escape from highly effective public CD8+ T-cell clonotypes by HIV.
Maria Candela Iglesias, Jorge R Almeida, +19 authors, Victor Appay.
Blood, 2011 Jul 08; 118(8). PMID: 21734237    Free PMC article.
The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine.
Signe C Svindland, Åsne Jul-Larsen, +5 authors, Rebecca J Cox.
Influenza Other Respir Viruses, 2011 Jul 14; 6(2). PMID: 21749672    Free PMC article.
Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells.
Joanne M Lumsden, Robert J Schwenk, +7 authors, Urszula Krzych.
PLoS One, 2011 Jul 23; 6(7). PMID: 21779319    Free PMC article.
Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions.
Brian D Rudd, Vanessa Venturi, +5 authors, Janko Nikolich-Žugich.
Proc Natl Acad Sci U S A, 2011 Aug 05; 108(33). PMID: 21813761    Free PMC article.
Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.
Shannon P Hilchey, Alexander F Rosenberg, +8 authors, Steven H Bernstein.
Blood, 2011 Aug 09; 118(13). PMID: 21821704    Free PMC article.
The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.
Matthew D Martin, Thomas C Wirth, +2 authors, Vladimir P Badovinac.
J Immunol, 2011 Aug 13; 187(6). PMID: 21832161    Free PMC article.
Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.
Bhaskar Upadhyaya, Yuzhi Yin, +2 authors, Calman Prussin.
J Immunol, 2011 Aug 19; 187(6). PMID: 21849680    Free PMC article.
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Wolfgang Kastenmuller, Georg Gasteiger, +5 authors, Ronald N Germain.
J Immunol, 2011 Aug 19; 187(6). PMID: 21849683    Free PMC article.
Biomarkers in T cell therapy clinical trials.
Michael Kalos.
J Transl Med, 2011 Aug 20; 9. PMID: 21851646    Free PMC article.
A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis.
Bappaditya Dey, Ruchi Jain, +3 authors, Anil K Tyagi.
PLoS One, 2011 Aug 23; 6(8). PMID: 21858087    Free PMC article.
Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells.
Alice E Denton, Brendan E Russ, +2 authors, Stephen J Turner.
Proc Natl Acad Sci U S A, 2011 Aug 31; 108(37). PMID: 21876173    Free PMC article.
Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques.
Katherine M Mladinich, Shari M Piaskowski, +10 authors, David I Watkins.
Immunogenetics, 2011 Sep 02; 64(2). PMID: 21881953
GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo.
Lara Vojnov, Mauricio A Martins, +19 authors, David I Watkins.
PLoS One, 2011 Sep 03; 6(8). PMID: 21887264    Free PMC article.
Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4(+) and CD8(+) polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins.
Raymond J Ning, Xue Q Xu, Kwok H Chan, Alan K S Chiang.
Immunology, 2011 Sep 08; 134(2). PMID: 21896011    Free PMC article.
A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.
Juan García-Arriaza, José Luis Nájera, +5 authors, Mariano Esteban.
PLoS One, 2011 Sep 13; 6(8). PMID: 21909386    Free PMC article.
GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination.
Valeria Judkowski, Alcinette Bunying, +11 authors, Clemencia Pinilla.
PLoS One, 2011 Sep 21; 6(9). PMID: 21931646    Free PMC article.
Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses.
Yolanda D Mahnke, Areej Saqr, +3 authors, Ramu A Subbramanian.
Vaccine, 2011 Sep 24; 29(47). PMID: 21939709    Free PMC article.
Tregs in infection and vaccinology: heroes or traitors?
Luciana Berod, Franz Puttur, Jochen Huehn, Tim Sparwasser.
Microb Biotechnol, 2011 Sep 29; 5(2). PMID: 21951341    Free PMC article.
Design of therapeutic vaccines: hepatitis B as an example.
Sarah Kutscher, Tanja Bauer, +2 authors, Ulrike Protzer.
Microb Biotechnol, 2011 Oct 01; 5(2). PMID: 21958338    Free PMC article.
Cyclic di-nucleotides: new era for small molecules as adjuvants.
Rimma Libanova, Pablo D Becker, Carlos A Guzmán.
Microb Biotechnol, 2011 Oct 01; 5(2). PMID: 21958423    Free PMC article.
A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis.
Navin Varadarajan, Boris Julg, +10 authors, J Christopher Love.
J Clin Invest, 2011 Oct 04; 121(11). PMID: 21965332    Free PMC article.
Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination.
Chiara Nembrini, Armando Stano, +5 authors, Jeffrey A Hubbell.
Proc Natl Acad Sci U S A, 2011 Oct 05; 108(44). PMID: 21969597    Free PMC article.
Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery.
Shajo Kunnath-Velayudhan, Maria Laura Gennaro.
Clin Microbiol Rev, 2011 Oct 07; 24(4). PMID: 21976609    Free PMC article.
Production of a particulate hepatitis C vaccine candidate by an engineered Lactococcus lactis strain.
Natalie A Parlane, Katrin Grage, +3 authors, Bernd H A Rehm.
Appl Environ Microbiol, 2011 Oct 11; 77(24). PMID: 21984246    Free PMC article.
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Joshua J Obar, Evan R Jellison, +4 authors, Leo Lefrançois.
J Immunol, 2011 Oct 12; 187(10). PMID: 21987662    Free PMC article.
Highly Cited.
Direct activation of antigen-presenting cells is required for CD8+ T-cell priming and tumor vaccination.
Wolfgang Kratky, Caetano Reis e Sousa, Annette Oxenius, Roman Spörri.
Proc Natl Acad Sci U S A, 2011 Oct 12; 108(42). PMID: 21987815    Free PMC article.
Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.
Martha Sedegah, Cindy Tamminga, +31 authors, Thomas L Richie.
PLoS One, 2011 Oct 18; 6(10). PMID: 22003383    Free PMC article.
Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component.
Cindy Tamminga, Martha Sedegah, +39 authors, Thomas L Richie.
PLoS One, 2011 Oct 18; 6(10). PMID: 22003411    Free PMC article.
OX40:OX40L axis: emerging targets for improving poxvirus-based CD8(+) T-cell vaccines against respiratory viruses.
John Goulding, Vikas Tahiliani, Shahram Salek-Ardakani.
Immunol Rev, 2011 Oct 25; 244(1). PMID: 22017437    Free PMC article.
Rapid, multiparameter profiling of cellular secretion using silicon photonic microring resonator arrays.
Matthew S Luchansky, Ryan C Bailey.
J Am Chem Soc, 2011 Nov 02; 133(50). PMID: 22040005    Free PMC article.
Differential expression of CD300a/c on human TH1 and TH17 cells.
Venkateswara R Simhadri, John L Mariano, +2 authors, Francisco Borrego.
BMC Immunol, 2011 Nov 04; 12. PMID: 22046970    Free PMC article.
T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.
Shalini Sharma, Aarthi Sundararajan, +6 authors, Barry T Rouse.
Proc Natl Acad Sci U S A, 2011 Nov 05; 108(47). PMID: 22052881    Free PMC article.
Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP.
Gabriel Kristian Pedersen, Thomas Ebensen, +4 authors, Rebecca Jane Cox.
PLoS One, 2011 Nov 10; 6(11). PMID: 22069479    Free PMC article.
Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses.
Raskit Lachmann, Martha Bajwa, +4 authors, Florian Kern.
J Virol, 2011 Nov 11; 86(2). PMID: 22072753    Free PMC article.
Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans.
Anne C Teirlinck, Matthew B B McCall, +7 authors, Robert W Sauerwein.
PLoS Pathog, 2011 Dec 07; 7(12). PMID: 22144890    Free PMC article.
Polyfunctional responses by human T cells result from sequential release of cytokines.
Qing Han, Neda Bagheri, +3 authors, J Christopher Love.
Proc Natl Acad Sci U S A, 2011 Dec 14; 109(5). PMID: 22160692    Free PMC article.
Highly Cited.
Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines.
Jennifer D Bassett, Stephanie L Swift, +5 authors, Jonathan L Bramson.
Mol Ther, 2011 Dec 22; 20(4). PMID: 22186790    Free PMC article.
Systems biology in vaccine design.
Adrien Six, Bertrand Bellier, Véronique Thomas-Vaslin, David Klatzmann.
Microb Biotechnol, 2011 Dec 23; 5(2). PMID: 22189033    Free PMC article.
Development of an antibody to bovine IL-2 reveals multifunctional CD4 T(EM) cells in cattle naturally infected with bovine tuberculosis.
Adam O Whelan, Bernardo Villarreal-Ramos, H Martin Vordermeier, Philip J Hogarth.
PLoS One, 2012 Jan 05; 6(12). PMID: 22216206    Free PMC article.
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.
Eleanor Barnes, Antonella Folgori, +25 authors, Paul Klenerman.
Sci Transl Med, 2012 Jan 06; 4(115). PMID: 22218690    Free PMC article.
Highly Cited.
Adaptive immunity to Anaplasma pathogens and immune dysregulation: implications for bacterial persistence.
Wendy C Brown.
Comp Immunol Microbiol Infect Dis, 2012 Jan 10; 35(3). PMID: 22226382    Free PMC article.
Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling.
Evandro R Winkelmann, Douglas G Widman, +7 authors, Gregg N Milligan.
Vaccine, 2012 Jan 10; 30(8). PMID: 22226862    Free PMC article.
In vitro sensitization of T cells with DC-associated/delivered HIV constructs can induce a polyfunctional CTL response, memory T-cell response, and virus suppression.
Swarali Kurle, Madhuri Thakar, Ashwini Shete, Ramesh Paranjape.
Viral Immunol, 2012 Jan 12; 25(1). PMID: 22233251    Free PMC article.
A hybrid multistage protein vaccine induces protective immunity against murine malaria.
Balwan Singh, Monica Cabrera-Mora, Jianlin Jiang, Alberto Moreno.
Infect Immun, 2012 Jan 19; 80(4). PMID: 22252877    Free PMC article.
Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever.
Kelly Lyn Warfield, Gene Garrard Olinger.
J Biomed Biotechnol, 2012 Jan 19; 2011. PMID: 22253531    Free PMC article.
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.
Evan W Newell, Natalia Sigal, +2 authors, Mark M Davis.
Immunity, 2012 Jan 24; 36(1). PMID: 22265676    Free PMC article.
Highly Cited.
Expanding roles for CD4⁺ T cells in immunity to viruses.
Susan L Swain, K Kai McKinstry, Tara M Strutt.
Nat Rev Immunol, 2012 Jan 24; 12(2). PMID: 22266691    Free PMC article.
Highly Cited. Review.
Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.
Laura K Mackay, Linda Wakim, +6 authors, Francis R Carbone.
J Immunol, 2012 Jan 25; 188(5). PMID: 22271651    Free PMC article.
Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.
Roberto De Pascalis, Alicia Y Chou, +3 authors, Karen L Elkins.
PLoS Pathog, 2012 Jan 26; 8(1). PMID: 22275868    Free PMC article.
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters.
Masaki Shoji, Shinji Yoshizaki, +2 authors, Masaru Shimada.
PLoS One, 2012 Jan 26; 7(1). PMID: 22276174    Free PMC article.
Travels in time: assessing the functional complexity of T cells.
W Nicholas Haining.
Proc Natl Acad Sci U S A, 2012 Feb 07; 109(5). PMID: 22307586    Free PMC article.
Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis.
Henriette Cordes, Ulla Riber, Tim K Jensen, Gregers Jungersen.
Vet Res, 2012 Feb 10; 43. PMID: 22316065    Free PMC article.
CD40 ligand enhances immunogenicity of vector-based vaccines in immunocompetent and CD4+ T cell deficient individuals.
Matthew W Auten, Weitao Huang, Guixiang Dai, Alistair J Ramsay.
Vaccine, 2012 Feb 22; 30(17). PMID: 22349523    Free PMC article.
Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4+ and CD8+ T cells in melanoma patients.
An M T Van Nuffel, Daphné Benteyn, +8 authors, Aude Bonehill.
Mol Ther, 2012 Mar 01; 20(5). PMID: 22371843    Free PMC article.
Can an immune-regulatory vaccine prevent HIV infection?
Tobias Boettler, Edecio Cunha-Neto, Jorge Kalil, Matthias von Herrath.
Expert Rev Anti Infect Ther, 2012 Mar 09; 10(3). PMID: 22397564    Free PMC article.
Signatures of T cells as correlates of immunity to Francisella tularensis.
Kjell Eneslätt, Monica Normark, +5 authors, Anders Sjöstedt.
PLoS One, 2012 Mar 14; 7(3). PMID: 22412866    Free PMC article.
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery.
David N Nguyen, Kerry P Mahon, +10 authors, Daniel G Anderson.
Proc Natl Acad Sci U S A, 2012 Mar 17; 109(14). PMID: 22421433    Free PMC article.
Expression of CD200 on AML blasts directly suppresses memory T-cell function.
S J Coles, R K Hills, +4 authors, A Tonks.
Leukemia, 2012 Mar 21; 26(9). PMID: 22430635    Free PMC article.
Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates.
Alexandra J Spencer, Fergal Hill, +9 authors, Adrian V S Hill.
PLoS One, 2012 Apr 04; 7(3). PMID: 22470455    Free PMC article.
The origin of diversity: studying the evolution of multi-faceted CD8+ T cell responses.
Veit R Buchholz, Patricia Gräf, Dirk H Busch.
Cell Mol Life Sci, 2012 Apr 06; 69(10). PMID: 22476589
Multivariate analysis of flow cytometric data using decision trees.
Svenja Simon, Reinhard Guthke, Thomas Kamradt, Oliver Frey.
Front Microbiol, 2012 Apr 10; 3. PMID: 22485112    Free PMC article.
Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques.
Takushi Nomura, Hiroyuki Yamamoto, +16 authors, Tetsuro Matano.
J Virol, 2012 Apr 12; 86(12). PMID: 22491464    Free PMC article.
Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection.
Kelly P Burke, Supriya Munshaw, +6 authors, Andrea L Cox.
J Immunol, 2012 Apr 18; 188(10). PMID: 22508927    Free PMC article.
In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells.
Scott G Kitchen, Bernard R Levin, +6 authors, Jerome A Zack.
PLoS Pathog, 2012 Apr 19; 8(4). PMID: 22511873    Free PMC article.
Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication.
Stephanie A Freel, Ralph A Picking, +13 authors, Georgia D Tomaras.
J Virol, 2012 Apr 20; 86(12). PMID: 22514337    Free PMC article.
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Adam R Hersperger, Nicholas A Siciliano, Laurence C Eisenlohr.
J Virol, 2012 Apr 26; 86(13). PMID: 22532670    Free PMC article.
Cyclosporin A and tacrolimus reduce T-cell polyfunctionality but not interferon-γ responses directed at cytomegalovirus.
Stephan Fuhrmann, Raskit Lachmann, +4 authors, Florian Kern.
Immunology, 2012 Apr 27; 136(4). PMID: 22533718    Free PMC article.
The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming.
Jacques Banchereau, LuAnn Thompson-Snipes, +6 authors, Eynav Klechevsky.
Blood, 2012 Apr 27; 119(24). PMID: 22535664    Free PMC article.
Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination.
Xi Li, Hongyu Miao, +4 authors, Tim R Mosmann.
Vaccine, 2012 May 05; 30(31). PMID: 22554464    Free PMC article.
Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery.
Isabelle Bouvier, Hélène Jusforgues-Saklani, +10 authors, Matthew L Albert.
Front Immunol, 2011 Jan 01; 2. PMID: 22566860    Free PMC article.
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Scott M Krummey, Mandy L Ford.
Front Immunol, 2012 May 09; 3. PMID: 22566919    Free PMC article.
CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.
Megan J Welch, John R Teijaro, +2 authors, Michael B A Oldstone.
Virology, 2012 May 15; 429(2). PMID: 22579352    Free PMC article.
The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants.
Åsne Jul-Larsen, Abdullah S Madhun, +3 authors, Rebecca J Cox.
Hum Vaccin Immunother, 2012 May 29; 8(5). PMID: 22634440    Free PMC article.
Immune and viral correlates of "secondary viral control" after treatment interruption in chronically HIV-1 infected patients.
Ellen Van Gulck, Lotte Bracke, +6 authors, Guido Vanham.
PLoS One, 2012 Jun 06; 7(5). PMID: 22666392    Free PMC article.
Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.
Samuel Amoah, Rama D Yammani, Jason M Grayson, Martha A Alexander-Miller.
J Immunol, 2012 Jun 19; 189(2). PMID: 22706075    Free PMC article.
High quality long-term CD4+ and CD8+ effector memory populations stimulated by DNA-LACK/MVA-LACK regimen in Leishmania major BALB/c model of infection.
Lucas Sánchez-Sampedro, Carmen Elena Gómez, +2 authors, Mariano Esteban.
PLoS One, 2012 Jun 21; 7(6). PMID: 22715418    Free PMC article.
The duration of antigen-stimulation significantly alters the diversity of multifunctional CD4 T cells measured by intracellular cytokine staining.
Daryan A Kaveh, Adam O Whelan, Philip J Hogarth.
PLoS One, 2012 Jun 22; 7(6). PMID: 22719990    Free PMC article.
Priming T-cell responses with recombinant measles vaccine vector in a heterologous prime-boost setting in non-human primates.
Diane L Bolton, Sampa Santra, +11 authors, Katarina Radošević.
Vaccine, 2012 Jun 27; 30(41). PMID: 22732429    Free PMC article.
Linear fidelity in quantification of anti-viral CD8+ T cells.
Inge E A Flesch, Natasha A Hollett, Yik Chun Wong, David C Tscharke.
PLoS One, 2012 Jun 30; 7(6). PMID: 22745779    Free PMC article.
Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection.
Yan Zhou, Benoît Callendret, +8 authors, Christopher M Walker.
J Exp Med, 2012 Jul 04; 209(8). PMID: 22753925    Free PMC article.
The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunity.
Rolf Billeskov, Tara T Elvang, Peter L Andersen, Jes Dietrich.
PLoS One, 2012 Jul 07; 7(6). PMID: 22768165    Free PMC article.
Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever.
Luzia Maria de-Oliveira-Pinto, Cíntia Ferreira Marinho, +11 authors, Claire Fernandes Kubelka.
PLoS One, 2012 Jul 21; 7(7). PMID: 22815692    Free PMC article.
Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans.
Janet C Lindow, Nathan Borochoff-Porte, +4 authors, Beth D Kirkpatrick.
PLoS Negl Trop Dis, 2012 Jul 21; 6(7). PMID: 22816004    Free PMC article.
A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guérin immunisation in children and adults.
Nicole Ritz, Madeleine Strach, +7 authors, Nigel Curtis.
PLoS One, 2012 Jul 26; 7(7). PMID: 22829867    Free PMC article.
Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes.
Lisa P Daley-Bauer, Grace M Wynn, Edward S Mocarski.
Immunity, 2012 Jul 31; 37(1). PMID: 22840843    Free PMC article.
Stability and function of secondary Th1 memory cells are dependent on the nature of the secondary stimulus.
Chulwoo Kim, David C Jay, Matthew A Williams.
J Immunol, 2012 Jul 31; 189(5). PMID: 22844122    Free PMC article.
Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis.
Rodolfo D Vicetti Miguel, Samantha A Maryak, Thomas L Cherpes.
J Immunol Methods, 2012 Aug 02; 384(1-2). PMID: 22850275    Free PMC article.
Optofluidic detection for cellular phenotyping.
Yi-Chung Tung, Nien-Tsu Huang, +6 authors, Katsuo Kurabayashi.
Lab Chip, 2012 Aug 03; 12(19). PMID: 22854915    Free PMC article.
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.
David C Gondek, Andrew J Olive, Georg Stary, Michael N Starnbach.
J Immunol, 2012 Aug 03; 189(5). PMID: 22855710    Free PMC article.
An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping.
Nien-Tsu Huang, Weiqiang Chen, +4 authors, Katsuo Kurabayashi.
Lab Chip, 2012 Aug 16; 12(20). PMID: 22892681    Free PMC article.
Induction of multi-functional T cells in a phase I clinical trial of dendritic cell immunotherapy in hepatitis C virus infected individuals.
Shuo Li, Stuart Roberts, +10 authors, Eric J Gowans.
PLoS One, 2012 Aug 21; 7(8). PMID: 22905088    Free PMC article.
Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella.
Matt Maybeno, Anke Redeker, +5 authors, Ramon Arens.
PLoS One, 2012 Aug 23; 7(8). PMID: 22912884    Free PMC article.
Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors.
Tara M Strutt, K Kai McKinstry, +2 authors, Susan L Swain.
Proc Natl Acad Sci U S A, 2012 Aug 29; 109(38). PMID: 22927425    Free PMC article.
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
Julia Ekeruche-Makinde, Mathew Clement, +17 authors, Andrew K Sewell.
J Biol Chem, 2012 Sep 07; 287(44). PMID: 22952231    Free PMC article.
Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cells.
Catherine Riou, Florette Treurnicht, +11 authors, CAPRISA 002 Study Team.
J Immunol, 2012 Sep 12; 189(8). PMID: 22966086    Free PMC article.
How the interval between prime and boost injection affects the immune response in a computational model of the immune system.
F Castiglione, F Mantile, P De Berardinis, A Prisco.
Comput Math Methods Med, 2012 Sep 22; 2012. PMID: 22997539    Free PMC article.
High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.
J A Akulian, M R Pipeling, +3 authors, J F McDyer.
Am J Transplant, 2012 Sep 29; 13(1). PMID: 23016698    Free PMC article.
Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.
Joshua M Walker, Hans-Peter Raué, Mark K Slifka.
J Virol, 2012 Oct 12; 86(24). PMID: 23055558    Free PMC article.
Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses.
Nicolas Çuburu, Barney S Graham, +5 authors, John T Schiller.
J Clin Invest, 2012 Nov 13; 122(12). PMID: 23143305    Free PMC article.
Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy.
Molly R Perkins, Caroline Ryschkewitsch, +17 authors, Daniel C Douek.
PLoS Pathog, 2012 Nov 13; 8(11). PMID: 23144619    Free PMC article.
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Wendy W J Unger, Todd Pearson, +10 authors, Bart O Roep.
PLoS One, 2012 Nov 17; 7(11). PMID: 23155466    Free PMC article.
A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine.
Signe C Svindland, Gabriel K Pedersen, +10 authors, Rebecca J Cox.
Influenza Other Respir Viruses, 2012 Nov 23; 7(6). PMID: 23170900    Free PMC article.
Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.
Mehrnoosh Doroudchi, Oleg Yegorov, +8 authors, Bader Yassine-Diab.
PLoS One, 2012 Nov 28; 7(11). PMID: 23185362    Free PMC article.
Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving.
Yvonne J Yamanaka, Gregory L Szeto, +6 authors, J Christopher Love.
Anal Chem, 2012 Dec 05; 84(24). PMID: 23205933    Free PMC article.
T-cell intrinsic and extrinsic mechanisms of p27Kip1 in the regulation of CD8 T-cell memory.
Anna Jatzek, Melba Marie Tejera, +2 authors, M Suresh.
Immunol Cell Biol, 2012 Dec 05; 91(2). PMID: 23207280    Free PMC article.
CD8 T cell memory: it takes all kinds.
Sara E Hamilton, Stephen C Jameson.
Front Immunol, 2012 Dec 12; 3. PMID: 23230436    Free PMC article.
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Byram W Bridle, Lan Chen, +9 authors, Yonghong Wan.
Mol Ther, 2013 Jan 09; 21(4). PMID: 23295947    Free PMC article.
Performance of multiplex commercial kits to quantify cytokine and chemokine responses in culture supernatants from Plasmodium falciparum stimulations.
Gemma Moncunill, John J Aponte, Augusto J Nhabomba, Carlota Dobaño.
PLoS One, 2013 Jan 10; 8(1). PMID: 23300981    Free PMC article.
Expansion of activated memory CD4+ T cells affects infectivity of CCR5-tropic HIV-1 in humanized NOD/SCID/JAK3null mice.
Kazutaka Terahara, Masayuki Ishige, +4 authors, Yasuko Tsunetsugu-Yokota.
PLoS One, 2013 Jan 10; 8(1). PMID: 23301078    Free PMC article.
Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.
Monica A McArthur, Marcelo B Sztein.
Clin Immunol, 2013 Jan 22; 146(2). PMID: 23333555    Free PMC article.
High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity.
Yao Lu, Jonathan J Chen, +8 authors, Rong Fan.
Anal Chem, 2013 Jan 24; 85(4). PMID: 23339603    Free PMC article.
Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.
Sophie Roetynck, Ally Olotu, +4 authors, Jean Langhorne.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383106    Free PMC article.
Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.
Danushka K Wijesundara, David C Tscharke, Ronald J Jackson, Charani Ranasinghe.
PLoS One, 2013 Feb 06; 8(1). PMID: 23383283    Free PMC article.
Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction.
Minsuk Kwak, Luye Mu, +3 authors, Rong Fan.
Front Oncol, 2013 Feb 08; 3. PMID: 23390614    Free PMC article.
Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes.
Mariana Manrique, Pamela A Kozlowski, +5 authors, Anna Aldovini.
J Virol, 2013 Feb 15; 87(8). PMID: 23408627    Free PMC article.
The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level.
Veit R Buchholz, Patricia Gräf, Dirk H Busch.
Front Immunol, 2013 Feb 21; 4. PMID: 23424063    Free PMC article.
Expansion of pathogen-specific mono- and multifunctional Th1 and Th17 cells in multi-focal tuberculous lymphadenitis.
Nathella Pavan Kumar, Rathinam Sridhar, +4 authors, Subash Babu.
PLoS One, 2013 Mar 02; 8(2). PMID: 23451159    Free PMC article.
Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia.
Philippe Totte, Aboubakar Yaya, +5 authors, François Thiaucourt.
PLoS One, 2013 Mar 08; 8(2). PMID: 23469008    Free PMC article.
Highly multiplexed quantitation of gene expression on single cells.
Maria H Dominguez, Pratip K Chattopadhyay, +6 authors, Mario Roederer.
J Immunol Methods, 2013 Mar 19; 391(1-2). PMID: 23500781    Free PMC article.
Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy.
Chao Ma, Ann F Cheung, +12 authors, James R Heath.
Cancer Discov, 2013 Mar 23; 3(4). PMID: 23519018    Free PMC article.
The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses.
Weidong Xu, Douglas M Watts, +11 authors, June Kan-Mitchell.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527138    Free PMC article.
Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi.
Raquel Tayar Nogueira, Alanderson Rocha Nogueira, +4 authors, Myrna Cristina Bonaldo.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527169    Free PMC article.
Humoral and cellular immunity to Plasmodium falciparum merozoite surface protein 1 and protection from infection with blood-stage parasites.
Ann M Moormann, Peter Odada Sumba, +7 authors, James W Kazura.
J Infect Dis, 2013 Mar 30; 208(1). PMID: 23539744    Free PMC article.
Attenuated and replication-competent vaccinia virus strains M65 and M101 with distinct biology and immunogenicity as potential vaccine candidates against pathogens.
Lucas Sánchez-Sampedro, Carmen Elena Gómez, +3 authors, Mariano Esteban.
J Virol, 2013 Apr 19; 87(12). PMID: 23596295    Free PMC article.
Emerging microfluidic tools for functional cellular immunophenotyping: a new potential paradigm for immune status characterization.
Weiqiang Chen, Nien-Tsu Huang, +3 authors, Jianping Fu.
Front Oncol, 2013 Apr 30; 3. PMID: 23626950    Free PMC article.
Involvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis.
Bingfen Yang, Xinjing Wang, Jing Jiang, Xiaoxing Cheng.
PLoS One, 2013 May 03; 8(4). PMID: 23638187    Free PMC article.
Ever closer to a prophylactic vaccine for HCV.
Leo Swadling, Paul Klenerman, Eleanor Barnes.
Expert Opin Biol Ther, 2013 May 09; 13(8). PMID: 23651228    Free PMC article.
Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response.
Jacoba G Slagter-Jäger, Alexa Raney, +3 authors, Irina Y Tcherepanova.
Mol Ther Nucleic Acids, 2013 May 09; 2. PMID: 23653155    Free PMC article.
Adjunctive immunotherapy with α-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice.
Priyanka Chauhan, Ruchi Jain, Bappaditya Dey, Anil K Tyagi.
Sci Rep, 2013 May 11; 3. PMID: 23660989    Free PMC article.
Consensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cells.
Olga Krotova, Elizaveta Starodubova, +12 authors, Maria G Isaguliants.
PLoS One, 2013 May 15; 8(5). PMID: 23667513    Free PMC article.
When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes.
Marco Antonio Moro-García, Rebeca Alonso-Arias, Carlos López-Larrea.
Front Immunol, 2013 May 16; 4. PMID: 23675374    Free PMC article.
Broadening of the T-cell repertoire to HIV-1 Gag p24 by vaccination of HLA-A2/DR transgenic mice with overlapping peptides in the CAF05 adjuvant.
Karen S Korsholm, Ingrid Karlsson, +5 authors, Anders Fomsgaard.
PLoS One, 2013 May 22; 8(5). PMID: 23691069    Free PMC article.
Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful.
K Kai McKinstry, Richard W Dutton, Susan L Swain, Tara M Strutt.
Arch Immunol Ther Exp (Warsz), 2013 May 28; 61(5). PMID: 23708562    Free PMC article.
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.
Janelle A Olson, Cameron McDonald-Hyman, Stephen C Jameson, Sara E Hamilton.
Immunity, 2013 Jun 12; 38(6). PMID: 23746652    Free PMC article.
Highly Cited.
Single cell functional proteomics for assessing immune response in cancer therapy: technology, methods, and applications.
Chao Ma, Rong Fan, Meltem Elitas.
Front Oncol, 2013 Jun 12; 3. PMID: 23755371    Free PMC article.
CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis.
Korey R Demers, Morgan A Reuter, Michael R Betts.
Immunol Rev, 2013 Jun 19; 254(1). PMID: 23772621    Free PMC article.
A heterologous prime/boost vaccination strategy enhances the immunogenicity of therapeutic vaccines for hepatitis C virus.
Anne Fournillier, Lars Frelin, +9 authors, Matti Sällberg.
J Infect Dis, 2013 Jun 19; 208(6). PMID: 23776192    Free PMC article.
Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways.
Juan García-Arriaza, Pilar Arnáez, +2 authors, Mariano Esteban.
PLoS One, 2013 Jul 05; 8(6). PMID: 23826170    Free PMC article.
Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.
Sophie Schussek, Angela Trieu, +3 authors, Denise L Doolan.
Infect Immun, 2013 Jul 10; 81(10). PMID: 23836827    Free PMC article.
Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity.
Il-Kyu Choi, Yan Li, +2 authors, Chae-Ok Yun.
PLoS One, 2013 Jul 12; 8(7). PMID: 23844018    Free PMC article.
Dendritic-cell-based therapeutic cancer vaccines.
Karolina Palucka, Jacques Banchereau.
Immunity, 2013 Jul 31; 39(1). PMID: 23890062    Free PMC article.
Highly Cited. Review.
Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection.
Cindy Tamminga, Martha Sedegah, +30 authors, Thomas L Richie.
Hum Vaccin Immunother, 2013 Aug 01; 9(10). PMID: 23899517    Free PMC article.
Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell-mediated HIV-1 dissemination.
Robbie B Mailliard, Kellie N Smith, +6 authors, Charles R Rinaldo.
J Immunol, 2013 Aug 06; 191(5). PMID: 23913962    Free PMC article.
Modeling pre-existing immunity to adenovirus in rodents: immunological requirements for successful development of a recombinant adenovirus serotype 5-based ebola vaccine.
Jin Huk Choi, Stephen C Schafer, +3 authors, Maria A Croyle.
Mol Pharm, 2013 Aug 07; 10(9). PMID: 23915419    Free PMC article.
Assessment of the phenotype and functionality of porcine CD8 T cell responses following vaccination with live attenuated classical swine fever virus (CSFV) and virulent CSFV challenge.
Giulia Franzoni, Nitin V Kurkure, +5 authors, Simon P Graham.
Clin Vaccine Immunol, 2013 Aug 24; 20(10). PMID: 23966552    Free PMC article.
CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases.
Rajarshi Bhadra, Dustin A Cobb, Imtiaz A Khan.
Crit Rev Immunol, 2013 Aug 27; 33(4). PMID: 23971530    Free PMC article.
Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model.
Rolf Billeskov, Jan P Christensen, +2 authors, Jes Dietrich.
PLoS One, 2013 Aug 27; 8(8). PMID: 23977248    Free PMC article.
Short-lived effector CD8 T cells induced by genetically attenuated malaria parasite vaccination express CD11c.
Laura A Cooney, Megha Gupta, +9 authors, Ruobing Wang.
Infect Immun, 2013 Aug 28; 81(11). PMID: 23980113    Free PMC article.
Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research.
Wei Wei, Young Shik Shin, +4 authors, James R Heath.
Genome Med, 2013 Sep 04; 5(8). PMID: 23998271    Free PMC article.
An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig.
D F Pinelli, M E Wagener, +7 authors, M L Ford.
Am J Transplant, 2013 Sep 07; 13(11). PMID: 24007441    Free PMC article.
Anti-dystrophin T cell responses in Duchenne muscular dystrophy: prevalence and a glucocorticoid treatment effect.
Kevin M Flanigan, Katie Campbell, +4 authors, Jerry R Mendell.
Hum Gene Ther, 2013 Sep 10; 24(9). PMID: 24010700    Free PMC article.
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia.
Armen Mardiros, Cedric Dos Santos, +14 authors, Stephen J Forman.
Blood, 2013 Sep 14; 122(18). PMID: 24030378    Free PMC article.
Highly Cited.
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Ross B Fulton, Kayla A Weiss, +2 authors, Steven M Varga.
J Virol, 2013 Sep 21; 87(23). PMID: 24049171    Free PMC article.
DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus.
Anna Gil, Siyuan Shen, +4 authors, Shan Lu.
Hum Vaccin Immunother, 2013 Sep 21; 9(10). PMID: 24051429    Free PMC article.
Oncolytic vesicular stomatitis virus quantitatively and qualitatively improves primary CD8+ T-cell responses to anticancer vaccines.
Byram W Bridle, Derek Clouthier, +5 authors, Yonghong Wan.
Oncoimmunology, 2013 Oct 02; 2(8). PMID: 24083086    Free PMC article.
Clinical validation of IFNγ/IL-10 and IFNγ/IL-2 FluoroSpot assays for the detection of Tr1 T cells and influenza vaccine monitoring in humans.
Anne Chauvat, Nadine Benhamouda, +11 authors, Eric Tartour.
Hum Vaccin Immunother, 2013 Oct 03; 10(1). PMID: 24084262    Free PMC article.
Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells.
Joel C Sunshine, Karlo Perica, Jonathan P Schneck, Jordan J Green.
Biomaterials, 2013 Oct 09; 35(1). PMID: 24099710    Free PMC article.
Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.
Jonathan D Buhrman, Kimberly R Jordan, +3 authors, Jill E Slansky.
J Biol Chem, 2013 Oct 10; 288(46). PMID: 24106273    Free PMC article.
Overnight resting of PBMC changes functional signatures of antigen specific T- cell responses: impact for immune monitoring within clinical trials.
Sarah Kutscher, Claudia J Dembek, +10 authors, Tanja Bauer.
PLoS One, 2013 Oct 23; 8(10). PMID: 24146841    Free PMC article.
Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.
Catherine Riou, Wendy A Burgers, +5 authors, Clive M Gray.
J Virol, 2013 Nov 15; 88(3). PMID: 24227857    Free PMC article.
Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.
Bram Slütter, Lecia L Pewe, Susan M Kaech, John T Harty.
Immunity, 2013 Nov 19; 39(5). PMID: 24238342    Free PMC article.
Highly Cited.
Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.
Alexandre de Titta, Marie Ballester, +5 authors, Jeffrey A Hubbell.
Proc Natl Acad Sci U S A, 2013 Nov 20; 110(49). PMID: 24248387    Free PMC article.
Highly Cited.
Discrimination of T-cell subsets and T-cell receptor repertoire distribution.
Isabell Bretschneider, Michael J Clemente, +6 authors, Hans-Dieter Volk.
Immunol Res, 2013 Nov 26; 58(1). PMID: 24272857
Chimeric antigen receptor therapy for cancer.
David M Barrett, Nathan Singh, +2 authors, Carl H June.
Annu Rev Med, 2013 Nov 28; 65. PMID: 24274181    Free PMC article.
Highly Cited. Review.
HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-cell Function But Normal CD4 T-cell Numbers in the Foreskin.
Jessica L Prodger, Taha Hirbod, +9 authors, Rakai Genital Immunology Research Group.
J Infect Dis, 2013 Nov 28; 209(8). PMID: 24277744    Free PMC article.
Sprouty-2 regulates HIV-specific T cell polyfunctionality.
Yen-Ling Chiu, Liang Shan, +11 authors, Jonathan P Schneck.
J Clin Invest, 2013 Dec 03; 124(1). PMID: 24292711    Free PMC article.
Immunological characterization of a modified vaccinia virus Ankara vector expressing the human papillomavirus 16 E1 protein.
Christelle Remy-Ziller, Claire Germain, +5 authors, Xavier Préville.
Clin Vaccine Immunol, 2013 Dec 07; 21(2). PMID: 24307238    Free PMC article.
Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice.
Lijun Xiao, Dimin Wang, +4 authors, Ling Chen.
Hum Vaccin Immunother, 2013 Dec 12; 10(3). PMID: 24326266    Free PMC article.
Human memory T cells: generation, compartmentalization and homeostasis.
Donna L Farber, Naomi A Yudanin, Nicholas P Restifo.
Nat Rev Immunol, 2013 Dec 18; 14(1). PMID: 24336101    Free PMC article.
Highly Cited. Review.
Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults.
María C Albareda, Ana M De Rissio, +9 authors, Susana A Laucella.
PLoS Negl Trop Dis, 2013 Dec 19; 7(12). PMID: 24349591    Free PMC article.
Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responses.
Peng Peng Ip, Annemarie Boerma, +4 authors, Toos Daemen.
Mol Ther, 2013 Dec 29; 22(4). PMID: 24370701    Free PMC article.
Immune response to mycobacterial infection: lessons from flow cytometry.
Nikoletta Rovina, Marios Panagiotou, +3 authors, Antonia Koutsoukou.
Clin Dev Immunol, 2014 Jan 01; 2013. PMID: 24376464    Free PMC article.
Proteome-wide screening reveals immunodominance in the CD8 T cell response against classical swine fever virus with antigen-specificity dependent on MHC class I haplotype expression.
Giulia Franzoni, Nitin V Kurkure, +5 authors, Simon P Graham.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376799    Free PMC article.
Deletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens.
Juan García-Arriaza, Carmen E Gómez, Carlos Óscar S Sorzano, Mariano Esteban.
J Virol, 2014 Jan 07; 88(6). PMID: 24390336    Free PMC article.
Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.
Niels Peter H Knudsen, Sara Nørskov-Lauritsen, +5 authors, Claus Aagaard.
Proc Natl Acad Sci U S A, 2014 Jan 08; 111(3). PMID: 24395772    Free PMC article.
Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells.
Evan W Newell, Mark M Davis.
Nat Biotechnol, 2014 Jan 21; 32(2). PMID: 24441473    Free PMC article.
Highly Cited. Review.
Novel vaccine regimen elicits strong airway immune responses and control of respiratory syncytial virus in nonhuman primates.
Thomas Grunwald, Matthias Tenbusch, +6 authors, Christiane Stahl-Hennig.
J Virol, 2014 Jan 24; 88(8). PMID: 24453366    Free PMC article.
Multi-functional flow cytometry analysis of CD4+ T cells as an immune biomarker for latent tuberculosis status in patients treated with tumour necrosis factor (TNF) antagonists.
I Sauzullo, R Scrivo, +5 authors, C M Mastroianni.
Clin Exp Immunol, 2014 Feb 18; 176(3). PMID: 24528189    Free PMC article.
Systems-level analysis of innate immunity.
Daniel E Zak, Vincent C Tam, Alan Aderem.
Annu Rev Immunol, 2014 Mar 25; 32. PMID: 24655298    Free PMC article.
Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells.
Smita K Nair, Gabriel De Leon, +9 authors, Duane A Mitchell.
Clin Cancer Res, 2014 Mar 25; 20(10). PMID: 24658154    Free PMC article.
Age-associated Epstein-Barr virus-specific T cell responses in seropositive healthy adults.
D Cárdenas Sierra, G Vélez Colmenares, +2 authors, S M Quijano Gómez.
Clin Exp Immunol, 2014 Mar 29; 177(1). PMID: 24666437    Free PMC article.
Human metapneumovirus SH and G glycoproteins inhibit macropinocytosis-mediated entry into human dendritic cells and reduce CD4+ T cell activation.
Cyril Le Nouën, Philippa Hillyer, +4 authors, Ursula J Buchholz.
J Virol, 2014 Mar 29; 88(11). PMID: 24672038    Free PMC article.
Maturation of innate responses to mycobacteria over the first nine months of life.
Muki S Shey, Elisa Nemes, +10 authors, Willem A Hanekom.
J Immunol, 2014 Apr 16; 192(10). PMID: 24733845    Free PMC article.
Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA.
Wen-Hsuan W Lin, Chien-Hsiung Pan, +2 authors, Diane E Griffin.
mBio, 2014 Apr 17; 5(2). PMID: 24736226    Free PMC article.
Elucidating the role of T cells in protection against and pathogenesis of dengue virus infections.
Anuja Mathew, Elizabeth Townsley, Francis A Ennis.
Future Microbiol, 2014 Apr 26; 9(3). PMID: 24762312    Free PMC article.
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
Rajarshi Bhadra, Magali M Moretto, +7 authors, Imtiaz A Khan.
J Clin Invest, 2014 Apr 26; 124(6). PMID: 24762437    Free PMC article.
Prime-boost bacillus Calmette-Guérin vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against Mycobacterium tuberculosis in mice.
Ying Xu, Enzhuo Yang, +7 authors, Honghai Wang.
Immunology, 2014 Apr 30; 143(2). PMID: 24773322    Free PMC article.
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.
Michael M Opata, Robin Stephens.
Curr Immunol Rev, 2014 May 03; 9(3). PMID: 24790593    Free PMC article.
T cell responses to viral infections - opportunities for Peptide vaccination.
Sietske Rosendahl Huber, Josine van Beek, +2 authors, Debbie van Baarle.
Front Immunol, 2014 May 06; 5. PMID: 24795718    Free PMC article.
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis.
Teresa Prezzemolo, Giuliana Guggino, +3 authors, Nadia Caccamo.
Front Immunol, 2014 May 06; 5. PMID: 24795723    Free PMC article.
Highly Cited. Review.
Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection.
Yue Zhang, Patricio Mena, Galina Romanov, James B Bliska.
Infect Immun, 2014 May 07; 82(7). PMID: 24799630    Free PMC article.
The longevity of memory CD8 T cell responses after repetitive antigen stimulations.
Deepa Rai, Matthew D Martin, Vladimir P Badovinac.
J Immunol, 2014 May 16; 192(12). PMID: 24829415    Free PMC article.
Dynamic functional modulation of CD4+ T cell recall responses is dependent on the inflammatory environment of the secondary stimulus.
Chulwoo Kim, David C Jay, Matthew A Williams.
PLoS Pathog, 2014 May 24; 10(5). PMID: 24854337    Free PMC article.
Novel vaccination strategies against tuberculosis.
Peter Andersen, Stefan H E Kaufmann.
Cold Spring Harb Perspect Med, 2014 Jun 04; 4(6). PMID: 24890836    Free PMC article.
Dietary pyridoxine controls efficacy of vitamin B6-auxotrophic tuberculosis vaccine bacillus Calmette-Guérin ΔureC::hly Δpdx1 in mice.
Martin Gengenbacher, Alexis Vogelzang, +3 authors, Stefan H E Kaufmann.
mBio, 2014 Jun 05; 5(3). PMID: 24895310    Free PMC article.
Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.
Adam R Hersperger, Nicholas A Siciliano, +2 authors, Laurence C Eisenlohr.
J Virol, 2014 Jun 06; 88(16). PMID: 24899206    Free PMC article.
Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.
Matthew L Bettini, Clifford Guy, +7 authors, Dario A A Vignali.
J Immunol, 2014 Jun 06; 193(1). PMID: 24899501    Free PMC article.
Proliferation conditions promote intrinsic changes in NK cells for an IL-10 response.
Margarite L Tarrio, Seung-Hwan Lee, +4 authors, Christine A Biron.
J Immunol, 2014 Jun 08; 193(1). PMID: 24907347    Free PMC article.
Characterization of pandemic influenza immune memory signature after vaccination or infection.
Olivia Bonduelle, Fabrice Carrat, +11 authors, Behazine Combadiere.
J Clin Invest, 2014 Jun 10; 124(7). PMID: 24911149    Free PMC article.
Changes in immunological profile as a function of urbanization and lifestyle.
Moustapha Mbow, Sanne E de Jong, +4 authors, Maria Yazdanbakhsh.
Immunology, 2014 Jun 14; 143(4). PMID: 24924958    Free PMC article.
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory.
Anna Okhrimenko, Joachim R Grün, +16 authors, Jun Dong.
Proc Natl Acad Sci U S A, 2014 Jun 14; 111(25). PMID: 24927527    Free PMC article.
Highly Cited.
Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.
Alexis Vogelzang, Carolina Perdomo, +4 authors, Stefan H E Kaufmann.
J Infect Dis, 2014 Jun 20; 210(12). PMID: 24943726    Free PMC article.
Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.
Alexandra J Spencer, Matthew G Cottingham, +8 authors, Adrian V S Hill.
PLoS One, 2014 Jun 20; 9(6). PMID: 24945248    Free PMC article.
Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression.
Frederik Graw, Roland R Regoes.
J Virol, 2014 Jun 27; 88(17). PMID: 24965450    Free PMC article.
Enhanced protective efficacy against Mycobacterium tuberculosis afforded by BCG prime-DNA boost regimen in an early challenge mouse model is associated with increased splenic interleukin-2-producing CD4 T-cell frequency post-vaccination.
Han Kang, Qin Yuan, +5 authors, Xiao-Yong Fan.
Immunology, 2014 Jun 27; 143(4). PMID: 24965530    Free PMC article.
Leishmania donovani Nucleoside Hydrolase Terminal Domains in Cross-Protective Immunotherapy Against Leishmania amazonensis Murine Infection.
Dirlei Nico, Daniele Crespo Gomes, +3 authors, Clarisa Beatriz Palatnik-de-Sousa.
Front Immunol, 2014 Jun 27; 5. PMID: 24966857    Free PMC article.
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents.
Synne Jenum, Harleen M S Grewal, +5 authors, TB Trials Study Group.
PLoS One, 2014 Jul 06; 9(7). PMID: 24992314    Free PMC article.
Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
Patricia A Darrah, Diane L Bolton, +13 authors, Robert A Seder.
J Immunol, 2014 Jul 16; 193(4). PMID: 25024382    Free PMC article.
Microdevices for examining immunological responses of single cells to HIV.
Jonghoon Choi, Yoon Jeong, Hyung-Seop Han, Kwan Hyi Lee.
Biosci Rep, 2014 Jul 17; 34(4). PMID: 25028990    Free PMC article.
Intact dendritic cell pathogen-recognition receptor functions associate with chronic hepatitis C treatment-induced viral clearance.
Ian Gaël Rodrigue-Gervais, Hawley Rigsby, +2 authors, Daniel Lamarre.
PLoS One, 2014 Jul 18; 9(7). PMID: 25033043    Free PMC article.
Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection.
Rudragouda Channappanavar, Craig Fett, +2 authors, Stanley Perlman.
J Virol, 2014 Jul 25; 88(19). PMID: 25056892    Free PMC article.
Highly Cited.
Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.
Mika Nagaoka, Yasuko Hatta, Yoshihiro Kawaoka, Laurent P Malherbe.
J Immunol, 2014 Aug 03; 193(6). PMID: 25086170    Free PMC article.
Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.
Raquel Gomez-Eerland, Bastiaan Nuijen, +8 authors, Annelies Jorritsma.
Hum Gene Ther Methods, 2014 Aug 22; 25(5). PMID: 25143008    Free PMC article.
Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis.
Rafael J Argüello, Carlos Vigliano, +6 authors, Susana A Laucella.
PLoS Negl Trop Dis, 2014 Aug 22; 8(8). PMID: 25144227    Free PMC article.
A complex role of herpes viruses in the disease process of multiple sclerosis.
Simone C Wuest, Ina Mexhitaj, +6 authors, Bibiana Bielekova.
PLoS One, 2014 Aug 26; 9(8). PMID: 25148387    Free PMC article.
Dose of incorporated immunodominant antigen in recombinant BCG impacts modestly on Th1 immune response and protective efficiency against Mycobacterium tuberculosis in mice.
Hui Ma, Kang Wu, +6 authors, Xiao-Yong Fan.
J Immunol Res, 2014 Aug 26; 2014. PMID: 25152895    Free PMC article.
Agonistic anti-CD40 enhances the CD8+ T cell response during vesicular stomatitis virus infection.
Julianne M Zickovich, Susan I Meyer, Hideo Yagita, Joshua J Obar.
PLoS One, 2014 Aug 29; 9(8). PMID: 25166494    Free PMC article.
T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses.
Jason M Schenkel, Kathryn A Fraser, +3 authors, David Masopust.
Science, 2014 Aug 30; 346(6205). PMID: 25170049    Free PMC article.
Highly Cited.
Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge.
Daphne A Stanley, Anna N Honko, +20 authors, Nancy J Sullivan.
Nat Med, 2014 Sep 10; 20(10). PMID: 25194571
Highly Cited.
Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10.
Parakkal Jovvian George, Rajamanickam Anuradha, +4 authors, Subash Babu.
PLoS Pathog, 2014 Sep 12; 10(9). PMID: 25211342    Free PMC article.
Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes.
Martha Sedegah, Michael R Hollingdale, +17 authors, Thomas L Richie.
PLoS One, 2014 Sep 12; 9(9). PMID: 25211344    Free PMC article.
A novel, live-attenuated vesicular stomatitis virus vector displaying conformationally intact, functional HIV-1 envelope trimers that elicits potent cellular and humoral responses in mice.
Svetlana Rabinovich, Rebecca L R Powell, +15 authors, Christopher L Parks.
PLoS One, 2014 Sep 13; 9(9). PMID: 25215861    Free PMC article.
Vaccine-induced CD107a+ CD4+ T cells are resistant to depletion following AIDS virus infection.
Kazutaka Terahara, Hiroshi Ishii, +5 authors, Tetsuro Matano.
J Virol, 2014 Oct 03; 88(24). PMID: 25275131    Free PMC article.
Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.
Natalie E Riddell, Stephen J Griffiths, +9 authors, Arne N Akbar.
Immunology, 2014 Oct 15; 144(4). PMID: 25314332    Free PMC article.
Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge.
Nicolas Çuburu, Kening Wang, +5 authors, John T Schiller.
J Virol, 2014 Oct 17; 89(1). PMID: 25320297    Free PMC article.
Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1.
Ana I Costa, Dan Koning, +9 authors, Debbie van Baarle.
J Virol, 2014 Oct 17; 89(1). PMID: 25320304    Free PMC article.
Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy.
Stefanie J Mandl, Ryan B Rountree, +6 authors, Alex Franzusoff.
J Immunother Cancer, 2014 Oct 21; 2(1). PMID: 25328681    Free PMC article.
Molecular regulation of effector and memory T cell differentiation.
John T Chang, E John Wherry, Ananda W Goldrath.
Nat Immunol, 2014 Nov 15; 15(12). PMID: 25396352    Free PMC article.
Highly Cited. Review.
Peripheral CD4+ T cell cytokine responses following human challenge and re-challenge with Campylobacter jejuni.
Kelly A Fimlaid, Janet C Lindow, +3 authors, Beth D Kirkpatrick.
PLoS One, 2014 Nov 15; 9(11). PMID: 25397604    Free PMC article.
Fast vaccine design and development based on correlates of protection (COPs).
Cécile van Els, Siri Mjaaland, +10 authors, Fredrik Oftung.
Hum Vaccin Immunother, 2014 Nov 27; 10(7). PMID: 25424803    Free PMC article.
Functional aspects of intrahepatic hepatitis B virus-specific T cells induced by therapeutic DNA vaccination.
Anette Brass, Lars Frelin, +2 authors, Gustaf Ahlén.
Mol Ther, 2014 Dec 11; 23(3). PMID: 25492563    Free PMC article.
Subsets of memory CD4+ T cell and bactericidal antibody response to Neisseria meningitidis serogroup C after immunization of HIV-infected children and adolescents.
Lucimar G Milagres, Priscilla R Costa, +7 authors, Esper G Kallas.
PLoS One, 2014 Dec 23; 9(12). PMID: 25532028    Free PMC article.
Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine.
Jin Huk Choi, Stephen C Schafer, Alexander N Freiberg, Maria A Croyle.
Mol Pharm, 2015 Jan 01; 12(8). PMID: 25549696    Free PMC article.
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.
Christoph Reissfelder, Slava Stamova, +14 authors, Philipp Beckhove.
J Clin Invest, 2015 Jan 07; 125(2). PMID: 25562322    Free PMC article.
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease.
Jose Mateus, Paola Lasso, +6 authors, Adriana Cuéllar.
PLoS Negl Trop Dis, 2015 Jan 09; 9(1). PMID: 25569149    Free PMC article.
PPE57 induces activation of macrophages and drives Th1-type immune responses through TLR2.
Ying Xu, Enzhuo Yang, +6 authors, Honghai Wang.
J Mol Med (Berl), 2015 Jan 15; 93(6). PMID: 25586105
CD4 T-cell subsets in malaria: TH1/TH2 revisited.
Damian Perez-Mazliah, Jean Langhorne.
Front Immunol, 2015 Jan 30; 5. PMID: 25628621    Free PMC article.
Highly Cited. Review.
The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species.
Matthew D J Dicks, Efrain Guzman, +4 authors, Matthew G Cottingham.
Vaccine, 2015 Jan 30; 33(9). PMID: 25629523    Free PMC article.
Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations.
Michelle J Boyle, Prasanna Jagannathan, +11 authors, Margaret E Feeney.
J Infect Dis, 2015 Feb 04; 212(3). PMID: 25646355    Free PMC article.
Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands.
Yao Lu, Qiong Xue, +7 authors, Rong Fan.
Proc Natl Acad Sci U S A, 2015 Feb 04; 112(7). PMID: 25646488    Free PMC article.
Highly Cited.
Filarial infection modulates the immune response to Mycobacterium tuberculosis through expansion of CD4+ IL-4 memory T cells.
Soumya Chatterjee, Carolyn E Clark, +2 authors, Thomas B Nutman.
J Immunol, 2015 Feb 11; 194(6). PMID: 25667413    Free PMC article.
Protein energy malnutrition during vaccination has limited influence on vaccine efficacy but abolishes immunity if administered during Mycobacterium tuberculosis infection.
Truc Hoang, Else Marie Agger, +2 authors, Peter Andersen.
Infect Immun, 2015 Mar 11; 83(5). PMID: 25754202    Free PMC article.
A novel respiratory syncytial virus (RSV) F subunit vaccine adjuvanted with GLA-SE elicits robust protective TH1-type humoral and cellular immunity in rodent models.
Stacie L Lambert, Shahin Aslam, +7 authors, Roderick S Tang.
PLoS One, 2015 Mar 21; 10(3). PMID: 25793508    Free PMC article.
Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.
Magali M Moretto, Danielle I Harrow, Imtiaz A Khan.
Semin Immunopathol, 2015 Apr 11; 37(3). PMID: 25860800    Free PMC article.
Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans.
R Wahid, S Fresnay, M M Levine, M B Sztein.
Mucosal Immunol, 2015 Apr 16; 8(6). PMID: 25872480    Free PMC article.
Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model.
Daniel O Villarreal, Nikolaos Svoronos, +4 authors, David B Weiner.
Vaccine, 2015 Apr 19; 33(35). PMID: 25887087    Free PMC article.
PCV2 vaccination induces IFN-γ/TNF-α co-producing T cells with a potential role in protection.
Hanna C Koinig, Stephanie C Talker, +6 authors, Armin Saalmüller.
Vet Res, 2015 Apr 19; 46. PMID: 25888899    Free PMC article.
Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data.
Lin Lin, Jacob Frelinger, +7 authors, Raphael Gottardo.
Cytometry A, 2015 Apr 25; 87(7). PMID: 25908275    Free PMC article.
Magnitude and kinetics of multifunctional CD4+ and CD8β+ T cells in pigs infected with swine influenza A virus.
Stephanie C Talker, Hanna C Koinig, +10 authors, Wilhelm Gerner.
Vet Res, 2015 May 15; 46. PMID: 25971313    Free PMC article.
Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection.
D F Pinelli, B S Wakeman, +2 authors, M L Ford.
Am J Transplant, 2015 May 21; 15(10). PMID: 25989700    Free PMC article.
Whole-animal imaging and flow cytometric techniques for analysis of antigen-specific CD8+ T cell responses after nanoparticle vaccination.
Lukasz J Ochyl, James J Moon.
J Vis Exp, 2015 May 21; (98). PMID: 25992469    Free PMC article.
Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease.
María Cecilia Albareda, Susana Adriana Laucella.
Mem Inst Oswaldo Cruz, 2015 May 21; 110(3). PMID: 25993507    Free PMC article.
Immunogenicity without Efficacy of an Adenoviral Tuberculosis Vaccine in a Stringent Mouse Model for Immunotherapy during Treatment.
S Anisah Alyahya, Scott T Nolan, +3 authors, Gyanu Lamichhane.
PLoS One, 2015 May 23; 10(5). PMID: 25996375    Free PMC article.
A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice.
Jason Gummow, Yanrui Li, +7 authors, Eric J Gowans.
J Virol, 2015 May 29; 89(15). PMID: 26018154    Free PMC article.
Evaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques.
A D White, C Sarfas, +7 authors, S A Sharpe.
Clin Vaccine Immunol, 2015 Jun 26; 22(9). PMID: 26108288    Free PMC article.
Boosting BCG-primed mice with chimeric DNA vaccine HG856A induces potent multifunctional T cell responses and enhanced protection against Mycobacterium tuberculosis.
Ping Ji, Zhi-Dong Hu, +7 authors, Xiao-Yong Fan.
Immunol Res, 2015 Jun 27; 64(1). PMID: 26111521
Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.
Elizabeth A Thompson, Frank Liang, +7 authors, Karin Loré.
J Immunol, 2015 Jul 01; 195(3). PMID: 26123354    Free PMC article.
Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: A randomized, placebo-controlled, phase 1 trial.
Friedrich H Schmitz-Winnenthal, Nicolas Hohmann, +26 authors, Philipp Beckhove.
Oncoimmunology, 2015 Jul 03; 4(4). PMID: 26137397    Free PMC article.
Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses.
Michelle Meyer, Tania Garron, +7 authors, Alexander Bukreyev.
J Clin Invest, 2015 Jul 15; 125(8). PMID: 26168222    Free PMC article.
Induction of Multifunctional Broadly Reactive T Cell Responses by a Plasmodium vivax Circumsporozoite Protein Recombinant Chimera.
Monica Cabrera-Mora, Jairo Andres Fonseca, +4 authors, Alberto Moreno.
Infect Immun, 2015 Jul 15; 83(9). PMID: 26169267    Free PMC article.
Epstein-Barr virus-specific CD8(+) T lymphocytes from diffuse large B cell lymphoma patients are functionally impaired.
D Cárdenas, G Vélez, +10 authors, S Quijano.
Clin Exp Immunol, 2015 Jul 16; 182(2). PMID: 26174440    Free PMC article.
Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.
Oscar Silva, Jillian Crocetti, +2 authors, M Carrie Miceli.
PLoS One, 2015 Jul 18; 10(7). PMID: 26186728    Free PMC article.
Human Infant Memory B Cell and CD4+ T Cell Responses to HibMenCY-TT Glyco-Conjugate Vaccine.
Angela Fuery, Peter C Richmond, Andrew J Currie.
PLoS One, 2015 Jul 21; 10(7). PMID: 26191794    Free PMC article.
Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in Strongyloides stercoralis Infection.
Rajamanickam Anuradha, Saravanan Munisankar, +3 authors, Subash Babu.
J Immunol, 2015 Jul 24; 195(5). PMID: 26202988    Free PMC article.
A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients.
Benjamin J D Weist, Patrizia Wehler, +6 authors, Nina Babel.
Kidney Int, 2015 Jul 30; 88(6). PMID: 26221751
Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile.
David Lissauer, Suzy A Eldershaw, +3 authors, Mark D Kilby.
Eur J Immunol, 2015 Aug 08; 45(10). PMID: 26249148    Free PMC article.
Characterization of the HCMV-Specific CD4 T Cell Responses that Are Associated with Protective Immunity.
Marie Wunsch, Wenji Zhang, +6 authors, Paul V Lehmann.
Viruses, 2015 Aug 11; 7(8). PMID: 26258786    Free PMC article.
Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges.
Lynda Coughlan, Teresa Lambe.
Vaccines (Basel), 2015 Sep 08; 3(2). PMID: 26343189    Free PMC article.
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.
Steven G Smith, Kaatje Smits, +10 authors, TBVI TB Biomarker Working Group.
PLoS One, 2015 Sep 15; 10(9). PMID: 26367374    Free PMC article.
Antigen-Specific Mammary Inflammation Depends on the Production of IL-17A and IFN-γ by Bovine CD4+ T Lymphocytes.
Pascal Rainard, Patricia Cunha, +5 authors, Gilles Foucras.
PLoS One, 2015 Sep 17; 10(9). PMID: 26375594    Free PMC article.
Naloxone/alum mixture a potent adjuvant for HIV-1 vaccine: induction of cellular and poly-isotypic humoral immune responses.
Sima Velashjerdi Farahani, Mohammad Reza Aghasadeghi, +3 authors, Mehdi Mahdavi.
Pathog Glob Health, 2015 Sep 26; 110(2). PMID: 26403975    Free PMC article.
Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.
Wendy Wj Unger, Christian T Mayer, +9 authors, Yvette van Kooyk.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405564    Free PMC article.
The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.
Shaniya H Khan, Matthew D Martin, +3 authors, Vladimir P Badovinac.
PLoS Pathog, 2015 Oct 03; 11(10). PMID: 26431533    Free PMC article.
Development and Function of Protective and Pathologic Memory CD4 T Cells.
Shafqat Ahrar Jaigirdar, Megan K L MacLeod.
Front Immunol, 2015 Oct 07; 6. PMID: 26441961    Free PMC article.
Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.
Matthew D Martin, Marie T Kim, +4 authors, Vladimir P Badovinac.
PLoS Pathog, 2015 Oct 21; 11(10). PMID: 26485703    Free PMC article.
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.
Geoffrey M Lynn, Richard Laga, +24 authors, Robert A Seder.
Nat Biotechnol, 2015 Oct 27; 33(11). PMID: 26501954    Free PMC article.
Highly Cited.
Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs.
Diane L Bolton, Amarendra Pegu, +13 authors, Richard A Koup.
J Virol, 2015 Nov 20; 90(3). PMID: 26581981    Free PMC article.
Priming of Qualitatively Superior Human Effector CD8+ T Cells Using TLR8 Ligand Combined with FLT3 Ligand.
Anna Lissina, Olivia Briceño, +5 authors, Victor Appay.
J Immunol, 2015 Nov 27; 196(1). PMID: 26608912    Free PMC article.
Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation.
Elliott T J Dunn, Edward S Taylor, +3 authors, Roslyn A Kemp.
Immunol Cell Biol, 2015 Dec 10; 94(5). PMID: 26647966
Protective Efficacy of an Inactive Vaccine Based on the LY02 Isolate against Acute Haemophilus parasuis Infection in Piglets.
Xiao-Hua Li, Guo-Zhen Zhao, +3 authors, Xiao-Yan Yang.
Biomed Res Int, 2015 Dec 22; 2015. PMID: 26688815    Free PMC article.
Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells.
Maurizio Perdicchio, Lenneke A M Cornelissen, +6 authors, Wendy W J Unger.
Oncotarget, 2016 Jan 08; 7(8). PMID: 26741508    Free PMC article.
Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.
Yen-Ling Chiu, Chung-Hao Lin, +5 authors, George C Wang.
Sci Rep, 2016 Jan 19; 6. PMID: 26778409    Free PMC article.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy.
Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox.
J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324    Free PMC article.
Highly Cited. Review.
Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.
Niels Peter H Knudsen, Anja Olsen, +14 authors, Else Marie Agger.
Sci Rep, 2016 Jan 23; 6. PMID: 26791076    Free PMC article.
Highly Cited.
Flagellin Encoded in Gene-Based Vector Vaccines Is a Route-Dependent Immune Adjuvant.
Hamada F Rady, Guixiang Dai, +2 authors, Alistair J Ramsay.
PLoS One, 2016 Feb 06; 11(2). PMID: 26844553    Free PMC article.
A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults.
Alice Minhinnick, Iman Satti, +13 authors, Helen McShane.
Vaccine, 2016 Feb 09; 34(11). PMID: 26854906    Free PMC article.
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.
Anna Lissina, David R Ambrozak, +12 authors, Victor Appay.
Immunol Cell Biol, 2016 Feb 11; 94(6). PMID: 26860368
Balancing Immune Protection and Immune Pathology by CD8(+) T-Cell Responses to Influenza Infection.
Susu Duan, Paul G Thomas.
Front Immunol, 2016 Feb 24; 7. PMID: 26904022    Free PMC article.
Highly Cited. Review.
The Non-structural Protein 5 and Matrix Protein Are Antigenic Targets of T Cell Immunity to Genotype 1 Porcine Reproductive and Respiratory Syndrome Viruses.
Helen Mokhtar, Miriam Pedrera, +8 authors, Simon P Graham.
Front Immunol, 2016 Feb 26; 7. PMID: 26909080    Free PMC article.
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
Amelia R Hofstetter, Juan A De La Cruz, +14 authors, Shivaprakash Gangappa.
PLoS One, 2016 Feb 26; 11(2). PMID: 26910342    Free PMC article.
The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Th1 immune response in mice.
Dongqing Gu, Wei Chen, +3 authors, Lang Bao.
Acta Biochim Biophys Sin (Shanghai), 2016 Feb 29; 48(4). PMID: 26922320    Free PMC article.
Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans.
Stephanie Fresnay, Monica A McArthur, +8 authors, Marcelo B Sztein.
J Transl Med, 2016 Mar 02; 14. PMID: 26928826    Free PMC article.
Long-lasting multifunctional CD8+ T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination.
Florian Wimmers, Erik H J G Aarntzen, +4 authors, I Jolanda M de Vries.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942087    Free PMC article.
Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
Susan P Foy, Stefanie J Mandl, +7 authors, Ryan B Rountree.
Cancer Immunol Immunother, 2016 Mar 11; 65(5). PMID: 26961085    Free PMC article.
Role of memory T cell subsets for adoptive immunotherapy.
Dirk H Busch, Simon P Fräßle, +2 authors, Stanley R Riddell.
Semin Immunol, 2016 Mar 16; 28(1). PMID: 26976826    Free PMC article.
Highly Cited. Review.
IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.
Jason M Schenkel, Kathryn A Fraser, +4 authors, David Masopust.
J Immunol, 2016 Mar 24; 196(9). PMID: 27001957    Free PMC article.
Highly Cited.
An HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses.
Mehdi Mahdavi, Massoumeh Ebtekar, +4 authors, Keyhan Azadmanesh.
Int J Mol Cell Med, 2016 Mar 26; 4(4). PMID: 27014646    Free PMC article.
Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination.
Qian Qi, Mary M Cavanagh, +13 authors, Jörg J Goronzy.
Sci Transl Med, 2016 Apr 01; 8(332). PMID: 27030598    Free PMC article.
Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10.
Prasanna Jagannathan, Katherine Bowen, +15 authors, Margaret E Feeney.
J Infect Dis, 2016 Apr 14; 214(2). PMID: 27067196    Free PMC article.
The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects.
Fábio Muniz de Oliveira, Monalisa Martins Trentini, Ana Paula Junqueira-Kipnis, André Kipnis.
Mem Inst Oswaldo Cruz, 2016 Apr 14; 111(4). PMID: 27074251    Free PMC article.
Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy.
Edouard Lhomme, Laura Richert, +6 authors, Rodolphe Thiébaut.
PLoS One, 2016 Apr 29; 11(4). PMID: 27124598    Free PMC article.
Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response.
Jessie Thalmensi, Elodie Pliquet, +12 authors, Pierre Langlade-Demoyen.
Oncoimmunology, 2016 May 04; 5(3). PMID: 27141336    Free PMC article.
Cutaneous Leishmaniasis Vaccination: A Matter of Quality.
Paula Mello De Luca, Amanda Beatriz Barreto Macedo.
Front Immunol, 2016 May 06; 7. PMID: 27148270    Free PMC article.
Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation.
Jasmine Li, Kristine Hardy, +22 authors, Sudha Rao.
J Cell Sci, 2016 May 07; 129(12). PMID: 27149922    Free PMC article.
Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells.
Francesca Ronchi, Camilla Basso, +5 authors, Federica Sallusto.
Nat Commun, 2016 May 18; 7. PMID: 27189410    Free PMC article.
Human T cell responses to Japanese encephalitis virus in health and disease.
Lance Turtle, Tanushka Bali, +24 authors, Tom Solomon.
J Exp Med, 2016 Jun 01; 213(7). PMID: 27242166    Free PMC article.
Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.
Duane Moogk, Shi Zhong, +11 authors, Michelle Krogsgaard.
J Immunol, 2016 Jun 09; 197(2). PMID: 27271569    Free PMC article.
Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity.
Nathella P Kumar, Kadar Moideen, +2 authors, Subash Babu.
Immunology, 2016 Jun 12; 149(1). PMID: 27289086    Free PMC article.
The Role of Lymphatic Niches in T Cell Differentiation.
Tara Capece, Minsoo Kim.
Mol Cells, 2016 Jun 17; 39(7). PMID: 27306645    Free PMC article.
Moving forward with human papillomavirus immunotherapies.
Nicolas Çuburu, John T Schiller.
Hum Vaccin Immunother, 2016 Jul 09; 12(11). PMID: 27388123    Free PMC article.
Construction and Immunological Evaluation of CpG-Au@HBc Virus-Like Nanoparticles as a Potential Vaccine.
Yarun Wang, Yue Wang, +5 authors, Guohong Zhuang.
Nanoscale Res Lett, 2016 Jul 21; 11(1). PMID: 27435343    Free PMC article.
Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals.
Marie T Kim, Samarchith P Kurup, Gabriel R Starbeck-Miller, John T Harty.
J Immunol, 2016 Jul 22; 197(5). PMID: 27439516    Free PMC article.
flowVS: channel-specific variance stabilization in flow cytometry.
Ariful Azad, Bartek Rajwa, Alex Pothen.
BMC Bioinformatics, 2016 Jul 29; 17. PMID: 27465477    Free PMC article.
Multiplexed Nanoplasmonic Temporal Profiling of T-Cell Response under Immunomodulatory Agent Exposure.
Bo-Ram Oh, Pengyu Chen, +5 authors, Katsuo Kurabayashi.
ACS Sens, 2016 Aug 02; 1(7). PMID: 27478873    Free PMC article.
Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia.
Leonar Arroyo, Mauricio Rojas, +2 authors, Luis F Barrera.
Clin Vaccine Immunol, 2016 Aug 05; 23(10). PMID: 27489136    Free PMC article.
Influenza A Virus Infection in Pigs Attracts Multifunctional and Cross-Reactive T Cells to the Lung.
Stephanie C Talker, Maria Stadler, +13 authors, Wilhelm Gerner.
J Virol, 2016 Aug 12; 90(20). PMID: 27512056    Free PMC article.
Functional Diversity of Cytomegalovirus-Specific T Cells Is Maintained in Older People and Significantly Associated With Protein Specificity and Response Size.
Martha Bajwa, Serena Vita, +8 authors, Florian Kern.
J Infect Dis, 2016 Aug 16; 214(9). PMID: 27521364    Free PMC article.
Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis.
Rolf Billeskov, Esterlina V Tan, +6 authors, Peter Andersen.
PLoS One, 2016 Aug 16; 11(8). PMID: 27525651    Free PMC article.
Immunotherapy for tuberculosis: future prospects.
Getahun Abate, Daniel F Hoft.
Immunotargets Ther, 2016 Aug 17; 5. PMID: 27529060    Free PMC article.
Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity.
Jilei Ma, Maopeng Tian, +5 authors, Zijie Zhou.
Oncotarget, 2016 Aug 28; 7(39). PMID: 27566581    Free PMC article.
A Recombinant Chimeric Ad5/3 Vector Expressing a Multistage Plasmodium Antigen Induces Protective Immunity in Mice Using Heterologous Prime-Boost Immunization Regimens.
Monica Cabrera-Mora, Jairo Andres Fonseca, +6 authors, Alberto Moreno.
J Immunol, 2016 Aug 31; 197(7). PMID: 27574299    Free PMC article.
Combination of TLR1/2 and TLR3 ligands enhances CD4(+) T cell longevity and antibody responses by modulating type I IFN production.
Bo Ryeong Lee, Soo Kyung Jeong, +4 authors, Sang-Jun Ha.
Sci Rep, 2016 Sep 02; 6. PMID: 27580796    Free PMC article.
HIV Suppression Restores the Lung Mucosal CD4+ T-Cell Viral Immune Response and Resolves CD8+ T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease.
Iulia Popescu, M Bradley Drummond, +9 authors, John F McDyer.
J Infect Dis, 2016 Oct 30; 214(10). PMID: 27613775    Free PMC article.
MHC class II tetramer analyses in AE37-vaccinated prostate cancer patients reveal vaccine-specific polyfunctional and long-lasting CD4(+) T-cells.
Eleftheria A Anastasopoulou, Ioannis F Voutsas, +2 authors, Sonia A Perez.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622033    Free PMC article.
Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a.
Rezwanul Wahid, Stephanie Fresnay, Myron M Levine, Marcelo B Sztein.
Clin Immunol, 2016 Sep 17; 173. PMID: 27634430    Free PMC article.
The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.
Eleni Panagioti, Anke Redeker, +4 authors, Ramon Arens.
PLoS Pathog, 2016 Sep 17; 12(9). PMID: 27637068    Free PMC article.
Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.
Tara M Strutt, Karl Kai McKinstry, +5 authors, Susan L Swain.
J Immunol, 2016 Sep 21; 197(8). PMID: 27647834    Free PMC article.
The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment".
Yaw Bediako, Joyce Mwongeli Ngoi, +6 authors, Francis Maina Ndungu.
BMC Med, 2016 Sep 24; 14(1). PMID: 27660116    Free PMC article.
Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review.
Nahid Maspi, Amir Abdoli, Fathemeh Ghaffarifar.
Pathog Glob Health, 2016 Sep 24; 110(6). PMID: 27660895    Free PMC article.
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119.
Jairo Andres Fonseca, Monica Cabrera-Mora, +5 authors, Alberto Moreno.
Sci Rep, 2016 Oct 07; 6. PMID: 27708348    Free PMC article.
Innate Immune Responses after Airway Epithelial Stimulation with Mycobacterium bovis Bacille-Calmette Guérin.
Erik Tenland, Gisela Håkansson, +5 authors, Gabriela Godaly.
PLoS One, 2016 Oct 11; 11(10). PMID: 27723804    Free PMC article.
Norovirus-Specific Memory T Cell Responses in Adult Human Donors.
Maria Malm, Kirsi Tamminen, Timo Vesikari, Vesna Blazevic.
Front Microbiol, 2016 Oct 19; 7. PMID: 27752254    Free PMC article.
Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.
Qian Qi, Mary M Cavanagh, +10 authors, Jörg J Goronzy.
PLoS Pathog, 2016 Oct 21; 12(10). PMID: 27764254    Free PMC article.
Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells.
João Luiz Silva-Filho, Celso Caruso-Neves, Ana Acacia Sá Pinheiro.
Sci Rep, 2016 Oct 27; 6. PMID: 27782175    Free PMC article.
Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.
Melissa Nyendak, Gwendolyn M Swarbrick, +11 authors, David M Lewinsohn.
Sci Rep, 2016 Nov 03; 6. PMID: 27805026    Free PMC article.
HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control.
Selena Viganò, Jordi J Negrón, +3 authors, Xu G Yu.
AIDS, 2016 Nov 12; 31(2). PMID: 27835619    Free PMC article.
Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations.
S Sharpe, A White, +10 authors, M Dennis.
Tuberculosis (Edinb), 2016 Nov 21; 101. PMID: 27865390    Free PMC article.
Teaching advanced flow cytometry in Africa: 10 years of lessons learned.
Elisa Nemes, Wendy A Burgers, +4 authors, Thomas Scriba.
Cytometry A, 2016 Nov 22; 89(11). PMID: 27870536    Free PMC article.
Immune signatures of protective spleen memory CD8 T cells.
Lilia Brinza, Sophia Djebali, +17 authors, Jacqueline Marvel.
Sci Rep, 2016 Nov 25; 6. PMID: 27883012    Free PMC article.
T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca2+ Influx.
Kristin Schmiedeberg, Hardy Krause, +3 authors, Monika C Brunner-Weinzierl.
PLoS One, 2016 Nov 29; 11(11). PMID: 27893767    Free PMC article.
Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution.
Lorena Martín-Jaular, Armando de Menezes-Neto, +6 authors, Hernando A Del Portillo.
Front Cell Dev Biol, 2016 Dec 03; 4. PMID: 27900319    Free PMC article.
The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses.
Ndongala Michel Lubaki, Patrick Younan, +4 authors, Alexander Bukreyev.
PLoS Pathog, 2016 Dec 09; 12(12). PMID: 27930745    Free PMC article.
Heterologous boosting with recombinant VSV-846 in BCG-primed mice confers improved protection against Mycobacterium infection.
Ming Zhang, Chunsheng Dong, Sidong Xiong.
Hum Vaccin Immunother, 2016 Dec 15; 13(4). PMID: 27960596    Free PMC article.
Functional impairment of infiltrating T cells in human colorectal cancer.
Edward S Taylor, John L McCall, +3 authors, Roslyn A Kemp.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999752    Free PMC article.
Poly-functional and long-lasting anticancer immune response elicited by a safe attenuated Pseudomonas aeruginosa vector for antigens delivery.
Xavier Chauchet, Dalil Hannani, +6 authors, Audrey Le Gouëllec.
Mol Ther Oncolytics, 2016 Dec 31; 3. PMID: 28035332    Free PMC article.
Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques.
Diane L Bolton, Kaimei Song, +2 authors, Mario Roederer.
Vaccine, 2017 Jan 04; 35(4). PMID: 28041780    Free PMC article.
Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus.
Denis Comte, Maria P Karampetsou, +3 authors, George C Tsokos.
Arthritis Rheumatol, 2017 Jan 12; 69(5). PMID: 28076903    Free PMC article.
Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods.
Sophie J Rhodes, Charlotte Sarfas, +7 authors, Richard G White.
Clin Vaccine Immunol, 2017 Jan 13; 24(3). PMID: 28077441    Free PMC article.
Vaccination to gain humoral immune memory.
Jana Sarkander, Shintaro Hojyo, Koji Tokoyoda.
Clin Transl Immunology, 2017 Jan 17; 5(12). PMID: 28090322    Free PMC article.
Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans.
Monica A McArthur, Wilbur H Chen, +2 authors, Marcelo B Sztein.
PLoS Negl Trop Dis, 2017 Jan 20; 11(1). PMID: 28103236    Free PMC article.
Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct.
Julie G Burel, Simon H Apte, +2 authors, Denise L Doolan.
JCI Insight, 2017 Feb 15; 2(3). PMID: 28194431    Free PMC article.
Cytomegalovirus-Responsive CD8+ T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease.
L E Higdon, J Trofe-Clark, +5 authors, J S Maltzman.
Am J Transplant, 2017 Feb 16; 17(8). PMID: 28199780    Free PMC article.
Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Reservoir.
Michael T Hensel, Jason D Marshall, +7 authors, Derek D Sloan.
J Virol, 2017 Feb 24; 91(9). PMID: 28228587    Free PMC article.
Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria.
João L Silva-Filho, Celso Caruso-Neves, Ana A S Pinheiro.
Front Cell Infect Microbiol, 2017 Mar 07; 7. PMID: 28261571    Free PMC article.
A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection.
Marcus Vinícius Alves-Silva, Dirlei Nico, +2 authors, Clarisa B Palatnik-de-Sousa.
Front Immunol, 2017 Mar 11; 8. PMID: 28280494    Free PMC article.
Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model.
Stephanie Fresnay, Monica A McArthur, +8 authors, Marcelo B Sztein.
Front Immunol, 2017 Mar 18; 8. PMID: 28303138    Free PMC article.
Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a Diameter-Dependent Manner.
Bala V K Karuturi, Shailendra B Tallapaka, +3 authors, Joseph A Vetro.
Mol Pharm, 2017 Mar 21; 14(5). PMID: 28319404    Free PMC article.
Leishmania donovani Nucleoside Hydrolase (NH36) Domains Induce T-Cell Cytokine Responses in Human Visceral Leishmaniasis.
Micheli Luize Barbosa Santos, Dirlei Nico, +11 authors, Clarisa Beatriz Palatnik-de-Sousa.
Front Immunol, 2017 Mar 23; 8. PMID: 28321221    Free PMC article.
The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.
Aditya Arra, Holger Lingel, +6 authors, Monika C Brunner-Weinzierl.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344884    Free PMC article.
Low Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.
Rolf Billeskov, Yichuan Wang, +6 authors, Jay A Berzofsky.
J Immunol, 2017 Mar 30; 198(9). PMID: 28348274    Free PMC article.
CD8+ T-cell mediated anti-malaria protection induced by malaria vaccines; assessment of hepatic CD8+ T cells by SCBC assay.
Jing Zhou, Alaina Kaiser, +7 authors, Moriya Tsuji.
Hum Vaccin Immunother, 2017 Apr 01; 13(7). PMID: 28362549    Free PMC article.
Dominant TNFα and impaired IL-2 cytokine profiles of CD4+ T cells from children with type-1 diabetes.
Julia Seyfarth, Katharina Förtsch, +7 authors, Marc Jacobsen.
Immunol Cell Biol, 2017 Apr 06; 95(7). PMID: 28377612
Molecular engineering and plant expression of an immunoglobulin heavy chain scaffold for delivery of a dengue vaccine candidate.
Mi-Young Kim, Craig Van Dolleweerd, +10 authors, Julian K Ma.
Plant Biotechnol J, 2017 Apr 20; 15(12). PMID: 28421694    Free PMC article.
CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.
Evans Raballah, Prakasha Kempaiah, +4 authors, John Michael Ong'echa.
PLoS One, 2017 Apr 21; 12(4). PMID: 28426727    Free PMC article.
Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes.
Jonathan Filskov, Marianne Mikkelsen, +5 authors, Else Marie Agger.
J Virol, 2017 Apr 28; 91(14). PMID: 28446674    Free PMC article.
A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis.
Javeed A Shah, Munyaradzi Musvosvi, +12 authors, Thomas R Hawn.
Am J Respir Crit Care Med, 2017 May 04; 196(4). PMID: 28463648    Free PMC article.
Single-cell profiling of lineage determining transcription factors in antigen-specific CD4+ T cells reveals unexpected complexity in recall responses during immune reconstitution.
Chansavath Phetsouphanh, Yin Xu, +2 authors, Anthony D Kelleher.
Immunol Cell Biol, 2017 May 10; 95(7). PMID: 28485382    Free PMC article.
Systematic Investigation of the Role of Surfactant Composition and Choice of oil: Design of a Nanoemulsion-Based Adjuvant Inducing Concomitant Humoral and CD4+ T-Cell Responses.
Signe Tandrup Schmidt, Malene Aaby Neustrup, +5 authors, Camilla Foged.
Pharm Res, 2017 May 19; 34(8). PMID: 28516400
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Influence of diabetes mellitus on immunity to human tuberculosis.
Pavan Kumar Nathella, Subash Babu.
Immunology, 2017 May 26; 152(1). PMID: 28543817    Free PMC article.
Highly Cited. Review.
Recombinant Bacille Calmette-Guérin coexpressing Ag85B-IFN-γ enhances the cell-mediated immunity in C57BL/6 mice.
Wei Liu, Ying Xu, +3 authors, Honghai Wang.
Exp Ther Med, 2017 Jun 02; 13(5). PMID: 28565847    Free PMC article.
Pathogen-Reactive T Helper Cell Analysis in the Pig.
Friederike Ebner, Patrycja Schwiertz, +7 authors, Susanne Hartmann.
Front Immunol, 2017 Jun 02; 8. PMID: 28567041    Free PMC article.
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Qi Yu, Xiaochun Wang, Xionglin Fan.
Front Immunol, 2017 Jun 03; 8. PMID: 28572807    Free PMC article.
Enrichment of IL-17A+ IFN-γ+ and IL-22+ IFN-γ+ T cell subsets is associated with reduction of NKp44+ ILC3s in the terminal ileum of Crohn's disease patients.
J Li, A L Doty, +6 authors, S C Glover.
Clin Exp Immunol, 2017 Jun 07; 190(1). PMID: 28586085    Free PMC article.
Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis.
Albanus O Moguche, Munyaradzi Musvosvi, +24 authors, Kevin B Urdahl.
Cell Host Microbe, 2017 Jun 16; 21(6). PMID: 28618268    Free PMC article.
Highly Cited.
Immunogenicity and Protective Efficacy of a Fusion Protein Tuberculosis Vaccine Combining Five Esx Family Proteins.
Zhi-Hao Xiang, Rui-Feng Sun, +6 authors, Jun Liu.
Front Cell Infect Microbiol, 2017 Jun 18; 7. PMID: 28620588    Free PMC article.
Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells.
Caroline Boudousquie, Giovanna Bossi, +3 authors, Namir J Hassan.
Immunology, 2017 Jun 24; 152(3). PMID: 28640942    Free PMC article.
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
Veronica Zanon, Karolina Pilipow, +8 authors, Enrico Lugli.
Eur J Immunol, 2017 Jul 04; 47(9). PMID: 28671275    Free PMC article.
Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8+ T Cell Responses Independently of Transgene Expression in DCs.
Alexandre Ghenassia, David-Alexandre Gross, +6 authors, Pascal Chappert.
Mol Ther, 2017 Jul 20; 25(10). PMID: 28720467    Free PMC article.
F1 Domain of the Leishmania (Leishmania) donovani Nucleoside Hydrolase Promotes a Th1 Response in Leishmania (Leishmania) infantum Cured Patients and in Asymptomatic Individuals Living in an Endemic Area of Leishmaniasis.
Eugenia Carrillo, Laura Fernandez, +7 authors, Clarisa B Palatnik-de-Sousa.
Front Immunol, 2017 Jul 28; 8. PMID: 28747911    Free PMC article.
Monocytes Phenotype and Cytokine Production in Human Immunodeficiency Virus-1 Infected Patients Receiving a Modified Vaccinia Ankara-Based HIV-1 Vaccine: Relationship to CD300 Molecules Expression.
Joana Vitallé, Olatz Zenarruzabeitia, +6 authors, Francisco Borrego.
Front Immunol, 2017 Aug 09; 8. PMID: 28785262    Free PMC article.
Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection.
Claudio Counoupas, Rachel Pinto, +3 authors, James A Triccas.
Sci Rep, 2017 Aug 19; 7(1). PMID: 28819247    Free PMC article.
MAGE-specific T cells detected directly ex-vivo correlate with complete remission in metastatic breast cancer patients after sequential immune-endocrine therapy.
Maxwell Janosky, Rachel L Sabado, +5 authors, Sylvia Adams.
J Immunother Cancer, 2014 Sep 16; 2(1). PMID: 28837000    Free PMC article.
A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.
Taylor B Poston, Yanyan Qu, +6 authors, Toni Darville.
J Immunol, 2017 Sep 01; 199(8). PMID: 28855311    Free PMC article.
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial.
Gemma Moncunill, Stephen C De Rosa, +16 authors, M Juliana McElrath.
Front Immunol, 2017 Sep 08; 8. PMID: 28878775    Free PMC article.
Altered expression of antigen-specific memory and regulatory T-cell subsets differentiate latent and active tuberculosis.
Balaji Pathakumari, Santhi Devasundaram, Alamelu Raja.
Immunology, 2017 Sep 08; 153(3). PMID: 28881482    Free PMC article.
Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude.
Kylie M Quinn, Wan-Ting Kan, +14 authors, Nicole L La Gruta.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886201    Free PMC article.
Genome-wide DNA methylation analysis of senescence in repetitively infected memory cytotoxic T lymphocytes.
Jumpei Shosaku.
Immunology, 2017 Sep 13; 153(2). PMID: 28898397    Free PMC article.
Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine.
Philippe Moris, Erik Jongert, Robbert G van der Most.
Hum Vaccin Immunother, 2017 Sep 22; 14(1). PMID: 28934066    Free PMC article.
New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells.
Edessa Negera, Kidist Bobosha, +5 authors, Diana N Lockwood.
Front Immunol, 2017 Oct 03; 8. PMID: 28966621    Free PMC article.
The Recombinant Bacille Calmette-Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing.
Natalie E Nieuwenhuizen, Prasad S Kulkarni, +5 authors, Stefan H E Kaufmann.
Front Immunol, 2017 Oct 05; 8. PMID: 28974949    Free PMC article.
Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).
Jan F Mieves, Kirsten Wittke, +3 authors, Leif G Hanitsch.
Curr Allergy Asthma Rep, 2017 Oct 07; 17(11). PMID: 28983790
Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice.
Thomas Ebensen, Jennifer Debarry, +6 authors, Carlos A Guzmán.
Front Immunol, 2017 Oct 17; 8. PMID: 29033942    Free PMC article.
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination.
Deborah A Lewinsohn, David M Lewinsohn, Thomas J Scriba.
Front Immunol, 2017 Oct 21; 8. PMID: 29051764    Free PMC article.
Highly Cited. Review.
An α-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major.
Eva Iniguez, Nathaniel S Schocker, +10 authors, Rosa A Maldonado.
PLoS Negl Trop Dis, 2017 Oct 27; 11(10). PMID: 29069089    Free PMC article.
Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.
Elizabeth A Reap, Carter M Suryadevara, +27 authors, John H Sampson.
Cancer Res, 2017 Nov 03; 78(1). PMID: 29093005    Free PMC article.
Density dependent re-tuning of autoreactive T cells alleviates their pathogenicity in a lymphopenic environment.
Eleanore Chuang, Marilyn Augustine, +2 authors, Nevil J Singh.
Immunol Lett, 2017 Nov 08; 192. PMID: 29111199    Free PMC article.
Quantification and phenotypic characterisation of peripheral IFN-γ producing leucocytes in chickens vaccinated against Newcastle disease.
S H Andersen, L Vervelde, +4 authors, T S Dalgaard.
Vet Immunol Immunopathol, 2017 Nov 14; 193-194. PMID: 29129224    Free PMC article.
Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.
Ryan A Zander, Rahul Vijay, +6 authors, Noah S Butler.
Cell Rep, 2017 Nov 16; 21(7). PMID: 29141217    Free PMC article.
Th1 cytokines, true functional signatures for protective immunity against TB?
Gucheng Zeng, Guoliang Zhang, Xinchun Chen.
Cell Mol Immunol, 2017 Nov 21; 15(3). PMID: 29151578    Free PMC article.
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response.
Qiong Xue, Emily Bettini, +11 authors, Jing Zhou.
J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157295    Free PMC article.
Local High-Dose Radiotherapy Induces Systemic Immunomodulating Effects of Potential Therapeutic Relevance in Oligometastatic Breast Cancer.
Elena Muraro, Carlo Furlan, +10 authors, Marco Trovo'.
Front Immunol, 2017 Nov 23; 8. PMID: 29163540    Free PMC article.
Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice.
Matthew D Martin, Derek B Danahy, +2 authors, Vladimir P Badovinac.
Front Immunol, 2017 Dec 08; 8. PMID: 29213267    Free PMC article.
Evaluation of Aggregated Ag85B Antigen for Its Biophysical Properties, Immunogenicity, and Vaccination Potential in a Murine Model of Tuberculosis Infection.
Faraz Ahmad, Swaleha Zubair, +3 authors, Mohammad Owais.
Front Immunol, 2017 Dec 13; 8. PMID: 29230211    Free PMC article.
Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.
Jian Hang Lam, Yen Leong Chua, +3 authors, Sylvie Alonso.
JCI Insight, 2017 Dec 22; 2(24). PMID: 29263304    Free PMC article.
Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice.
Claudio Counoupas, Rachel Pinto, +4 authors, James A Triccas.
NPJ Vaccines, 2016 Sep 15; 1. PMID: 29263854    Free PMC article.
A defined subunit vaccine that protects against vector-borne visceral leishmaniasis.
Malcolm S Duthie, Lais Pereira, +21 authors, Steven G Reed.
NPJ Vaccines, 2017 Dec 22; 2. PMID: 29263878    Free PMC article.
Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity.
Margherita Coccia, Catherine Collignon, +18 authors, Arnaud M Didierlaurent.
NPJ Vaccines, 2017 Dec 22; 2. PMID: 29263880    Free PMC article.
Highly Cited.
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines.
Johannes Lutz, Sandra Lazzaro, +8 authors, Mariola Fotin-Mleczek.
NPJ Vaccines, 2017 Dec 22; 2. PMID: 29263884    Free PMC article.
Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection.
Jessica Badolato-Corrêa, Juan Camilo Sánchez-Arcila, +8 authors, Luzia Maria de-Oliveira-Pinto.
Immun Inflamm Dis, 2017 Dec 29; 6(2). PMID: 29282904    Free PMC article.
Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease.
Kathryn Jones, Leroy Versteeg, +7 authors, Maria Elena Bottazzi.
Infect Immun, 2018 Jan 10; 86(4). PMID: 29311242    Free PMC article.
High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis.
Rolf Billeskov, Thomas Lindenstrøm, +6 authors, Peter Andersen.
Front Immunol, 2018 Jan 31; 8. PMID: 29379507    Free PMC article.
Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial.
Stéphane Pillet, Éric Aubin, +5 authors, Nathalie Landry.
NPJ Vaccines, 2018 Feb 02; 3. PMID: 29387473    Free PMC article.
IFN-Gamma-Dependent and Independent Mechanisms of CD4⁺ Memory T Cell-Mediated Protection from Listeria Infection.
Stephanie M Meek, Matthew A Williams.
Pathogens, 2018 Feb 14; 7(1). PMID: 29438281    Free PMC article.
Liposomal Elongation Factor-1α Triggers Effector CD4 and CD8 T Cells for Induction of Long-Lasting Protective Immunity against Visceral Leishmaniasis.
Abdus Sabur, Sudipta Bhowmick, +6 authors, Nahid Ali.
Front Immunol, 2018 Feb 15; 9. PMID: 29441060    Free PMC article.
Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium.
Kirsten E Lyke, Abdoulaye Dabo, +4 authors, Marcelo B Sztein.
Front Immunol, 2018 Feb 17; 8. PMID: 29449839    Free PMC article.
Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model.
Kunitaka Yoshida, Mitsuhiro Iyori, +12 authors, Shigeto Yoshida.
Sci Rep, 2018 Mar 03; 8(1). PMID: 29497047    Free PMC article.
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.
Eleni Panagioti, Paul Klenerman, +2 authors, Ramon Arens.
Front Immunol, 2018 Mar 06; 9. PMID: 29503649    Free PMC article.
Nanoparticle-Fusion Protein Complexes Protect against Mycobacterium tuberculosis Infection.
Peter Hart, Alastair Copland, +8 authors, Rajko Reljic.
Mol Ther, 2018 Mar 09; 26(3). PMID: 29518353    Free PMC article.
T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans.
Franklin R Toapanta, Paula J Bernal, +2 authors, Marcelo B Sztein.
J Transl Med, 2018 Mar 15; 16(1). PMID: 29534721    Free PMC article.
Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection.
Maopeng Tian, Zijie Zhou, +3 authors, Nadeem Ullah.
Front Immunol, 2018 Mar 15; 9. PMID: 29535714    Free PMC article.
Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection.
Janice K P Lam, K F Hui, +3 authors, Alan K S Chiang.
Front Microbiol, 2018 Mar 31; 9. PMID: 29599759    Free PMC article.
The Significance of Tumor Necrosis Factor Receptor Type II in CD8+ Regulatory T Cells and CD8+ Effector T Cells.
Lin-Lin Ye, Xiao-Shan Wei, +2 authors, Qiong Zhou.
Front Immunol, 2018 Apr 07; 9. PMID: 29623079    Free PMC article.
Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection.
Michael M Opata, Samad A Ibitokou, +6 authors, Robin Stephens.
PLoS Pathog, 2018 Apr 10; 14(4). PMID: 29630679    Free PMC article.
Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes.
Liudmila A Stepanova, Eugenia S Mardanova, +9 authors, Liudmila M Tsybalova.
J Biomed Sci, 2018 Apr 11; 25(1). PMID: 29631629    Free PMC article.
Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs.
Sita S Withers, Peter F Moore, +8 authors, Robert B Rebhun.
Dev Comp Immunol, 2018 Jun 04; 87. PMID: 29859828    Free PMC article.
NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis.
Dirlei Nico, Fernanda Martins Almeida, +7 authors, Clarisa Beatriz Palatnik-de-Sousa.
Front Immunol, 2018 Jun 06; 9. PMID: 29867949    Free PMC article.
Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8+ T Cell Dynamics.
Roland Frank, Michael Gabel, +2 authors, Frederik Graw.
Front Immunol, 2018 Jun 13; 9. PMID: 29892289    Free PMC article.
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.
John Rossi, Patrick Paczkowski, +13 authors, Adrian Bot.
Blood, 2018 Jun 14; 132(8). PMID: 29895668    Free PMC article.
Highly Cited.
The Regulation of Inflammation by Innate and Adaptive Lymphocytes.
David Alex Cronkite, Tara M Strutt.
J Immunol Res, 2018 Jul 12; 2018. PMID: 29992170    Free PMC article.
T Cell Immunity To Enterovirus 71 Infection In Humans And Implications For Vaccine Development.
Pinn Tsin Isabel Yee, Chit Laa Poh.
Int J Med Sci, 2018 Aug 21; 15(11). PMID: 30123051    Free PMC article.
The Profile of T Cell Responses in Bacille Calmette-Guérin-Primed Mice Boosted by a Novel Sendai Virus Vectored Anti-Tuberculosis Vaccine.
Zhidong Hu, Ling Gu, +3 authors, Xiao-Yong Fan.
Front Immunol, 2018 Aug 21; 9. PMID: 30123219    Free PMC article.
The small heat shock protein HSPB1 protects mice from sepsis.
Elise R Breed, Carolyn A Hilliard, +11 authors, Craig M Coopersmith.
Sci Rep, 2018 Aug 23; 8(1). PMID: 30131526    Free PMC article.
Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years.
Mai-Chi Trieu, Fan Zhou, +3 authors, Rebecca Jane Cox.
NPJ Vaccines, 2018 Aug 23; 3. PMID: 30131880    Free PMC article.
Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making.
Sophie J Rhodes, Jeremie Guedj, +5 authors, Richard G White.
NPJ Vaccines, 2018 Sep 25; 3. PMID: 30245860    Free PMC article.
Exploring the impact of inoculum dose on host immunity and morbidity to inform model-based vaccine design.
Andreas Handel, Yan Li, +3 authors, Rustom Antia.
PLoS Comput Biol, 2018 Oct 03; 14(10). PMID: 30273336    Free PMC article.
Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen.
Ana L Chiodetti, María F Sánchez Vallecillo, +8 authors, Belkys A Maletto.
Front Immunol, 2018 Oct 27; 9. PMID: 30364187    Free PMC article.
Phenotype, Polyfunctionality, and Antiviral Activity of in vitro Stimulated CD8+ T-Cells From HIV+ Subjects Who Initiated cART at Different Time-Points After Acute Infection.
Jimena Salido, María Julia Ruiz, +8 authors, Gabriela Turk.
Front Immunol, 2018 Nov 09; 9. PMID: 30405632    Free PMC article.
Heterologous Boost Following Mycobacterium bovis BCG Reduces the Late Persistent, Rather Than the Early Stage of Intranasal Tuberculosis Challenge Infection.
Yaqi Wu, Ming Cai, +4 authors, Xionglin Fan.
Front Immunol, 2018 Nov 15; 9. PMID: 30425711    Free PMC article.
Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.
Denny Miley Cárdenas, Angie Carolina Sánchez, +5 authors, Nestor Fabián Galvis.
BMC Gastroenterol, 2018 Dec 12; 18(1). PMID: 30526523    Free PMC article.
Identification of a First Human Norovirus CD8+ T Cell Epitope Restricted to HLA-A*0201 Allele.
Maria Malm, Timo Vesikari, Vesna Blazevic.
Front Immunol, 2018 Dec 14; 9. PMID: 30542352    Free PMC article.
IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure.
Lenette L Lu, Malisa T Smith, +15 authors, Galit Alter.
Nat Med, 2019 May 22; 25(6). PMID: 31110348    Free PMC article.
Highly Cited.
Human lung tissue resident memory T cells in health and disease.
Mark E Snyder, Donna L Farber.
Curr Opin Immunol, 2019 Jul 03; 59. PMID: 31265968    Free PMC article.
Early Diagnosis of Pathogen Infection by Cell-Based Activation Immunoassay.
Erez Bar-Haim, Shahar Rotem, +11 authors, Ofer Cohen.
Cells, 2019 Aug 25; 8(9). PMID: 31443439    Free PMC article.
The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).
Andrew R Kick, Amanda F Amaral, +4 authors, Tobias Käser.
Viruses, 2019 Sep 01; 11(9). PMID: 31470568    Free PMC article.
Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R- Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity.
Prossy Naluyima, Kerri G Lal, +21 authors, Michael A Eller.
J Immunol, 2019 Sep 15; 203(8). PMID: 31519862    Free PMC article.
Association of dengue virus-specific polyfunctional T-cell responses with clinical disease severity in acute dengue infection.
Dulharie T Wijeratne, Samitha Fernando, +7 authors, Gathsaurie N Malavige.
Immun Inflamm Dis, 2019 Oct 01; 7(4). PMID: 31568656    Free PMC article.
Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4)- and Programmed Death 1 (PD-1)-Mediated Regulation of Monofunctional and Dual Functional CD4+ and CD8+ T-Cell Responses in a Chronic Helminth Infection.
Anuradha Rajamanickam, Saravanan Munisankar, +2 authors, Subash Babu.
Infect Immun, 2019 Oct 02; 87(12). PMID: 31570560    Free PMC article.
Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants.
Agano Kiravu, Sophia Osawe, +12 authors, Clive M Gray.
Front Immunol, 2019 Oct 28; 10. PMID: 31649662    Free PMC article.
Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
Clare M Smith, Megan K Proulx, +8 authors, Christopher M Sassetti.
mBio, 2019 Nov 28; 10(6). PMID: 31772048    Free PMC article.
CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection.
Yoshiro Yamashita, Toshiyuki Oe, +9 authors, Koya Ariyoshi.
Front Immunol, 2019 Dec 19; 10. PMID: 31849981    Free PMC article.
Effect of Timing and Complement Receptor Antagonism on Intragraft Recruitment and Protolerogenic Effects of Mesenchymal Stromal Cells in Murine Kidney Transplantation.
Federica Casiraghi, Marta Todeschini, +10 authors, Giuseppe Remuzzi.
Transplantation, 2019 Feb 26; 103(6). PMID: 30801518    Free PMC article.
Rational Design and In Vivo Characterization of Vaccine Adjuvants.
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Dennis Christensen.
ILAR J, 2019 Jan 10; 59(3). PMID: 30624655    Free PMC article.
Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection.
Shailendra B Tallapaka, Bala V K Karuturi, +6 authors, Joseph A Vetro.
Int J Pharm, 2019 May 12; 565. PMID: 31077762    Free PMC article.
Cell mediated immune responses elicited in volunteers following immunization with candidate live oral Salmonella enterica serovar Paratyphi A attenuated vaccine strain CVD 1902.
Rezwanul Wahid, Karen L Kotloff, Myron M Levine, Marcelo B Sztein.
Clin Immunol, 2019 Mar 09; 201. PMID: 30849494    Free PMC article.
Circulating gluten-specific, but not CMV-specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire.
Laura Cook, C Mee Ling Munier, +6 authors, David van Bockel.
Clin Transl Immunology, 2020 Jan 21; 9(1). PMID: 31956412    Free PMC article.
High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence.
Laura Carretero-Iglesia, Barbara Couturaud, +5 authors, Nathalie Rufer.
Front Immunol, 2020 Jan 24; 10. PMID: 31969886    Free PMC article.
Synthetic Peptides Elicit Strong Cellular Immunity in Visceral Leishmaniasis Natural Reservoir and Contribute to Long-Lasting Polyfunctional T-Cells in BALB/c Mice.
Rory Cristiane Fortes De Brito, Jamille Mirelle de Oliveira Cardoso, +8 authors, Alexandre Barbosa Reis.
Vaccines (Basel), 2019 Oct 31; 7(4). PMID: 31661776    Free PMC article.
T-cell aging in end-stage renal disease: an evolving story with CMV.
TienYu Owen Yang, Yi-Fang Chuang, Yen-Ling Chiu.
Med Microbiol Immunol, 2019 Mar 25; 208(3-4). PMID: 30903371
Engineering Targeting Materials for Therapeutic Cancer Vaccines.
Priscilla S Briquez, Sylvie Hauert, +4 authors, Jeffrey A Hubbell.
Front Bioeng Biotechnol, 2020 Mar 03; 8. PMID: 32117911    Free PMC article.
Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults.
Ian Shannon, Chantelle L White, +3 authors, Jennifer L Nayak.
Sci Rep, 2019 Jan 30; 9(1). PMID: 30692574    Free PMC article.
Multivariate profiling of African green monkey and rhesus macaque T lymphocytes.
Wail M Hassan, Gregory F Burton, +3 authors, Mackenzie E Johnson.
Sci Rep, 2019 Mar 20; 9(1). PMID: 30886198    Free PMC article.
Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity.
João Manuel Santos, Camilla Heiniö, +9 authors, Akseli Hemminki.
J Immunother Cancer, 2020 Jan 16; 8(1). PMID: 31940588    Free PMC article.
Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival.
Emmanuel S Antonarakis, Eric J Small, +10 authors, Charles G Drake.
Clin Cancer Res, 2018 Jun 03; 24(19). PMID: 29858218    Free PMC article.
Targeting innate immunity for tuberculosis vaccination.
Shabaana A Khader, Maziar Divangahi, +12 authors, Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18.
J Clin Invest, 2019 Sep 04; 129(9). PMID: 31478909    Free PMC article.
Interferon gamma (IFN-γ) negative CD4+ and CD8+ T-cells can produce immune mediators in response to viral antigens.
Ritah Nakiboneka, Susan Mugaba, +5 authors, Jennifer Serwanga.
Vaccine, 2018 Nov 22; 37(1). PMID: 30459072    Free PMC article.
Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.
Andrew D Graustein, Elizabeth A Misch, +11 authors, Thomas R Hawn.
PLoS One, 2018 Dec 15; 13(12). PMID: 30550567    Free PMC article.
Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization.
Aneesh Thakur, Cristina Rodríguez-Rodríguez, +7 authors, Camilla Foged.
Front Immunol, 2018 Dec 18; 9. PMID: 30555488    Free PMC article.
Mycobacterium leprae Recombinant Antigen Induces High Expression of Multifunction T Lymphocytes and Is Promising as a Specific Vaccine for Leprosy.
Márcio Bezerra-Santos, Marise do Vale-Simon, +10 authors, Amélia Ribeiro de Jesus.
Front Immunol, 2019 Jan 12; 9. PMID: 30631322    Free PMC article.
Understanding Resistance vs. Susceptibility in Visceral Leishmaniasis Using Mouse Models of Leishmania infantum Infection.
Begoña Pérez-Cabezas, Pedro Cecílio, +3 authors, Anabela Cordeiro-da-Silva.
Front Cell Infect Microbiol, 2019 Mar 19; 9. PMID: 30881923    Free PMC article.
Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.
K Kai McKinstry, Fahmida Alam, +5 authors, Tara M Strutt.
PLoS Pathog, 2019 Aug 15; 15(8). PMID: 31412088    Free PMC article.
Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Trypanosoma cruzi.
Andrés Sanchez Alberti, Augusto E Bivona, +10 authors, Emilio L Malchiodi.
Front Immunol, 2020 Mar 11; 11. PMID: 32153562    Free PMC article.
Age Distribution of Multiple Functionally Relevant Subsets of CD4+ T Cells in Human Blood Using a Standardized and Validated 14-Color EuroFlow Immune Monitoring Tube.
Vitor Botafogo, Martín Pérez-Andres, +19 authors, Alberto Orfao.
Front Immunol, 2020 Mar 17; 11. PMID: 32174910    Free PMC article.
Immune Responses to Middle East Respiratory Syndrome Coronavirus During the Acute and Convalescent Phases of Human Infection.
Hyoung-Shik Shin, Yeonjae Kim, +8 authors, Dong-Gyun Lim.
Clin Infect Dis, 2018 Jul 31; 68(6). PMID: 30060038    Free PMC article.
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Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation.
Mark E Rudolph, Monica A McArthur, +3 authors, Marcelo B Sztein.
Front Immunol, 2019 Mar 20; 10. PMID: 30886613    Free PMC article.
Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum.
Jayaum S Booth, Seema A Patil, +3 authors, Marcelo B Sztein.
Front Immunol, 2019 Mar 30; 10. PMID: 30923521    Free PMC article.
Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes.
Janna Heide, Kerrie C Vaughan, +2 authors, Julian Schulze Zur Wiesch.
Front Immunol, 2019 Apr 06; 10. PMID: 30949162    Free PMC article.
Shaping of CD56bri Natural Killer Cells in Patients With Steroid-Refractory/Resistant Acute Graft-vs.-Host Disease via Extracorporeal Photopheresis.
Ming Ni, Lei Wang, +18 authors, Anita Schmitt.
Front Immunol, 2019 Apr 06; 10. PMID: 30949182    Free PMC article.
The F1F3 Recombinant Chimera of Leishmania donovani-Nucleoside Hydrolase (NH36) and Its Epitopes Induce Cross-Protection Against Leishmania (V.) braziliensis Infection in Mice.
Marcus Vinícius Alves-Silva, Dirlei Nico, Paula Melo de Luca, Clarisa B Palatnik de-Sousa.
Front Immunol, 2019 Apr 27; 10. PMID: 31024556    Free PMC article.
Nucleoside Hydrolase NH 36: A Vital Enzyme for the Leishmania Genus in the Development of T-Cell Epitope Cross-Protective Vaccines.
Clarisa Beatriz Palatnik-de-Sousa.
Front Immunol, 2019 May 02; 10. PMID: 31040850    Free PMC article.
Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells.
Marjolein Schluck, Roel Hammink, +2 authors, Jorieke Weiden.
Front Immunol, 2019 May 28; 10. PMID: 31130945    Free PMC article.
Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.
Ga Hye Lee, Kyung Taek Hong, +3 authors, Hyoung Jin Kang.
Clin Transl Immunology, 2020 Apr 14; 9(4). PMID: 32280463    Free PMC article.
Recalling the Future: Immunological Memory Toward Unpredictable Influenza Viruses.
Maria Auladell, Xiaoxiao Jia, +5 authors, Katherine Kedzierska.
Front Immunol, 2019 Jul 18; 10. PMID: 31312199    Free PMC article.
Inactivated Lactobacillus plantarum Carrying a Surface-Displayed Ag85B-ESAT-6 Fusion Antigen as a Booster Vaccine Against Mycobacterium tuberculosis Infection.
Katarzyna Kuczkowska, Alastair Copland, +5 authors, Rajko Reljic.
Front Immunol, 2019 Jul 30; 10. PMID: 31354727    Free PMC article.
Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B.
Patricia Pérez, María Q Marín, +4 authors, Juan García-Arriaza.
Vaccines (Basel), 2020 Feb 12; 8(1). PMID: 32041218    Free PMC article.
Mesenchymal Stromal Cells for Transplant Tolerance.
Manuel Alfredo Podestà, Giuseppe Remuzzi, Federica Casiraghi.
Front Immunol, 2019 Jun 25; 10. PMID: 31231393    Free PMC article.
Cutting Edge: Characterization of Human Tissue-Resident Memory T Cells at Different Infection Sites in Patients with Tuberculosis.
Qianting Yang, Mingxia Zhang, +10 authors, Li Ma.
J Immunol, 2020 Apr 02; 204(9). PMID: 32229539    Free PMC article.
The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease.
Katherine Kedzierska, Marios Koutsakos.
Viral Immunol, 2020 Apr 15; 33(3). PMID: 32286182    Free PMC article.
MHC-restricted Ag85B-specific CD8+ T cells are enhanced by recombinant BCG prime and DNA boost immunization in mice.
Shihoko Komine-Aizawa, Jiansheng Jiang, +5 authors, Mitsuo Honda.
Eur J Immunol, 2019 May 29; 49(9). PMID: 31135967    Free PMC article.
Influence of immune aging on vaccine responses.
Claire E Gustafson, Chulwoo Kim, Cornelia M Weyand, Jörg J Goronzy.
J Allergy Clin Immunol, 2020 May 11; 145(5). PMID: 32386655    Free PMC article.
Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.
Ryan A Zander, Rahul Vijay, +6 authors, Noah S Butler.
Cell Rep, 2018 Apr 26; 23(4). PMID: 29694898    Free PMC article.
Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.
Kelly Walton, Mario R Fernandez, +18 authors, Brian C Betts.
JCI Insight, 2020 Apr 08; 5(9). PMID: 32255769    Free PMC article.
Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception.
Stefanie Gryzik, Yen Hoang, +8 authors, Ria Baumgrass.
Elife, 2020 May 23; 9. PMID: 32441253    Free PMC article.
Clofazimine enhances the efficacy of BCG revaccination via stem cell-like memory T cells.
Shaheer Ahmad, Debapriya Bhattacharya, +4 authors, Gobardhan Das.
PLoS Pathog, 2020 May 22; 16(5). PMID: 32437421    Free PMC article.
CD4+ T cells support polyfunctionality of cytotoxic CD8+ T cells with memory potential in immunological control of tumor.
Naoko Imai, Isao Tawara, +3 authors, Hiroaki Ikeda.
Cancer Sci, 2020 Apr 19; 111(6). PMID: 32304127    Free PMC article.
Protective Efficacy of Inhaled BCG Vaccination Against Ultra-Low Dose Aerosol M. tuberculosis Challenge in Rhesus Macaques.
Andrew D White, Charlotte Sarfas, +11 authors, Sally A Sharpe.
Pharmaceutics, 2020 Apr 30; 12(5). PMID: 32344890    Free PMC article.
Evaluation of T-activated proteins as recall antigens to monitor Epstein-Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting.
Nina Körber, Uta Behrends, Ulrike Protzer, Tanja Bauer.
J Transl Med, 2020 Jun 20; 18(1). PMID: 32552697    Free PMC article.
T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients.
Arnaud G L'Huillier, Victor H Ferreira, +5 authors, Deepali Kumar.
Sci Rep, 2020 Jun 24; 10(1). PMID: 32572168    Free PMC article.
Oncolytic viruses for cancer immunotherapy.
Otto Hemminki, João Manuel Dos Santos, Akseli Hemminki.
J Hematol Oncol, 2020 Jul 01; 13(1). PMID: 32600470    Free PMC article.
Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis.
Rory Cristiane Fortes De Brito, Jeronimo Conceição Ruiz, +8 authors, Alexandre Barbosa Reis.
Vaccines (Basel), 2020 May 31; 8(2). PMID: 32471081    Free PMC article.
Modified Vaccinia Ankara-Vectored Vaccine Expressing Nucleoprotein and Matrix Protein 1 (M1) Activates Mucosal M1-Specific T-Cell Immunity and Tissue-Resident Memory T Cells in Human Nasopharynx-Associated Lymphoid Tissue.
Suttida Puksuriwong, Muhammad S Ahmed, +6 authors, Qibo Zhang.
J Infect Dis, 2019 Nov 20; 222(5). PMID: 31740938    Free PMC article.
PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer.
Marco Donia, Julie Westerlin Kjeldsen, +11 authors, Inge Marie Svane.
Clin Cancer Res, 2017 Jul 07; 23(19). PMID: 28679768    Free PMC article.
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells.
Benjamin J Meckiff, Ciro Ramírez-Suástegui, +11 authors, Pandurangan Vijayanand.
SSRN, 2020 Aug 04;. PMID: 32742242    Free PMC article.
Revisiting cellular immune response to oncogenic Marek's disease virus: the rising of avian T-cell immunity.
Yi Yang, Maoli Dong, +2 authors, Shaobin Shang.
Cell Mol Life Sci, 2020 Feb 23; 77(16). PMID: 32080753    Free PMC article.
Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development.
Sachin Mani, Franklin R Toapanta, +6 authors, Marcelo B Sztein.
Vaccine, 2019 Jun 25; 37(34). PMID: 31230883    Free PMC article.
Children From the Age of Three Show a Developmental Switch in T-Cell Differentiation.
Julienne Knolle, Mandy Pierau, +5 authors, Monika C Brunner-Weinzierl.
Front Immunol, 2020 Aug 28; 11. PMID: 32849561    Free PMC article.
Multiplexed, Sequential Secretion Analysis of the Same Single Cells Reveals Distinct Effector Response Dynamics Dependent on the Initial Basal State.
Zhuo Chen, Yao Lu, +3 authors, Rong Fan.
Adv Sci (Weinh), 2019 May 09; 6(9). PMID: 31065513    Free PMC article.
Immunization with Mycobacterium tuberculosis-Specific Antigens Bypasses T Cell Differentiation from Prior Bacillus Calmette-Guérin Vaccination and Improves Protection in Mice.
Claus Aagaard, Niels Peter Hell Knudsen, +10 authors, Rasmus Mortensen.
J Immunol, 2020 Sep 06; 205(8). PMID: 32887748    Free PMC article.
Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection.
Bennett Davenport, Jens Eberlein, +6 authors, Dirk Homann.
J Immunol, 2020 Sep 20; 205(8). PMID: 32948682    Free PMC article.
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Jose Ordovas-Montanes, Semir Beyaz, Seth Rakoff-Nahoum, Alex K Shalek.
Nat Rev Immunol, 2020 Feb 06; 20(5). PMID: 32015472    Free PMC article.
SIV antigen-specific effects on immune responses induced by vaccination with DNA electroporation and plasmid IL-12.
Ross W Lindsay, Ian Ouellette, +7 authors, C Richter King.
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Vaccine strategies for the Mtb/HIV copandemic.
Riti Sharan, Deepak Kaushal.
NPJ Vaccines, 2020 Oct 22; 5. PMID: 33083030    Free PMC article.
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19.
Benjamin J Meckiff, Ciro Ramírez-Suástegui, +12 authors, Pandurangan Vijayanand.
Cell, 2020 Oct 24; 183(5). PMID: 33096020    Free PMC article.
Airway delivery of both a BCG prime and adenoviral boost drives CD4 and CD8 T cells into the lung tissue parenchyma.
Daryan A Kaveh, M Carmen Garcia-Pelayo, +3 authors, Philip J Hogarth.
Sci Rep, 2020 Nov 01; 10(1). PMID: 33127956    Free PMC article.
A Longitudinal Study of Immune Cells in Severe COVID-19 Patients.
Didier Payen, Maxime Cravat, +5 authors, Marcelo De Carvalho Bittencourt.
Front Immunol, 2020 Nov 13; 11. PMID: 33178207    Free PMC article.
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Biochem Biophys Res Commun, 2020 Nov 17; 538. PMID: 33190827    Free PMC article.
HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.
Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, +6 authors, Kailapuri Gangatharan Murugavel.
Curr HIV Res, 2018 Dec 14; 16(4). PMID: 30543175    Free PMC article.
A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates.
Miguel J Rodo, Virginie Rozot, +4 authors, Thomas J Scriba.
PLoS Pathog, 2019 Mar 05; 15(3). PMID: 30830940    Free PMC article.
Immunization with a recombinant antigen composed of conserved blocks from TSA56 provides broad genotype protection against scrub typhus.
Hong-Il Kim, Na-Young Ha, +5 authors, Nam-Hyuk Cho.
Emerg Microbes Infect, 2019 Jun 27; 8(1). PMID: 31237478    Free PMC article.
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.
Annika Nelde, Tatjana Bilich, +39 authors, Juliane S Walz.
Nat Immunol, 2020 Oct 02; 22(1). PMID: 32999467
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Gaëlle Breton, Pilar Mendoza, +7 authors, Michel C Nussenzweig.
bioRxiv, 2020 Dec 18;. PMID: 33330867    Free PMC article.
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells.
Kim-Long Truong, Stephan Schlickeiser, +16 authors, Birgit Sawitzki.
Nat Commun, 2019 May 24; 10(1). PMID: 31118448    Free PMC article.
HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients.
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Front Immunol, 2021 Jan 12; 11. PMID: 33424856    Free PMC article.
B and T Cell Immunity in Tissues and Across the Ages.
Jayaum S Booth, Franklin R Toapanta.
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Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers.
Tone Otterhaug, Sylvia Janetzki, +9 authors, Anders Høgset.
Front Immunol, 2021 Jan 26; 11. PMID: 33488576    Free PMC article.
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Gaëlle Breton, Pilar Mendoza, +7 authors, Michel C Nussenzweig.
J Exp Med, 2021 Feb 04; 218(4). PMID: 33533915    Free PMC article.
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Mark M Davis.
Curr Opin Immunol, 2020 Jul 01; 65. PMID: 32604000    Free PMC article.
Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults.
Athena P Y Li, Carolyn A Cohen, +11 authors, Sophie A Valkenburg.
NPJ Vaccines, 2021 Feb 18; 6(1). PMID: 33594050    Free PMC article.
IFN-γ+ CD4+T cell-driven prophylactic potential of recombinant LDBPK_252400 hypothetical protein of Leishmania donovani against visceral leishmaniasis.
Sunita Yadav, Jay Prakash, +4 authors, Vikash Kumar Dubey.
Cell Immunol, 2021 Jan 15; 361. PMID: 33445051    Free PMC article.
Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines.
Ariel Isaacs, Zheyi Li, +7 authors, Keith J Chappell.
Vaccines (Basel), 2021 Jan 28; 9(2). PMID: 33498370    Free PMC article.
CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy.
Jennifer R Richardson, Anna Schöllhorn, Cécile Gouttefangeas, Juliane Schuhmacher.
Cancers (Basel), 2021 Feb 07; 13(4). PMID: 33546283    Free PMC article.
Immune profiling of Mycobacterium tuberculosis-specific T cells in recent and remote infection.
Cheleka A M Mpande, Virginie Rozot, +7 authors, ACS Study Team.
EBioMedicine, 2021 Feb 21; 64. PMID: 33610126    Free PMC article.
Detection of Antigen-specific T cells in Spleens of Vaccinated Mice Applying 3[H]-Thymidine Incorporation Assay and Luminex Multiple Cytokine Analysis Technology.
Maria Agallou, Evdokia Karagouni.
Bio Protoc, 2019 Jun 05; 9(11). PMID: 33654777    Free PMC article.
Effector memory CD8 T cell response elicits Hepatitis E Virus genotype 3 pathogenesis in the elderly.
Hicham El Costa, Jordi Gouilly, +5 authors, Jacques Izopet.
PLoS Pathog, 2021 Feb 23; 17(2). PMID: 33617602    Free PMC article.
Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates.
Peng Xiao, Krista Dienger-Stambaugh, +9 authors, Paul Spearman.
Front Immunol, 2021 Mar 16; 12. PMID: 33717130    Free PMC article.
Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates.
Hadar Marcus, Emily Thompson, +8 authors, Nancy J Sullivan.
Front Immunol, 2021 Apr 02; 12. PMID: 33790899    Free PMC article.
Rapid Isolation of Functional ex vivo Human Skin Tissue-Resident Memory T Lymphocytes.
Weijie Du, Daniel Lenz, +9 authors, Jun Dong.
Front Immunol, 2021 Apr 09; 12. PMID: 33828548    Free PMC article.
Integrin Activation Enables Sensitive Detection of Functional CD4+ and CD8+ T Cells: Application to Characterize SARS-CoV-2 Immunity.
Anna Schöllhorn, Juliane Schuhmacher, +8 authors, Stoyan Dimitrov.
Front Immunol, 2021 Apr 16; 12. PMID: 33854501    Free PMC article.
T cell phenotypes in COVID-19 - a living review.
Stephanie J Hanna, Amy S Codd, +15 authors, Anita Milicic.
Oxf Open Immunol, 2021 Feb 13; 2(1). PMID: 33575657    Free PMC article.
Complement-activated human endothelial cells stimulate increased polyfunctionality in alloreactive T cells.
Catherine B Xie, Jing Zhou, Sean Mackay, Jordan S Pober.
Am J Transplant, 2021 Jan 09; 21(5). PMID: 33415805    Free PMC article.
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
Jianmin Zuo, Alexander C Dowell, +21 authors, Paul Moss.
Nat Immunol, 2021 Mar 07; 22(5). PMID: 33674800    Free PMC article.
Therapeutic Liposomal Vaccines for Dendritic Cell Activation or Tolerance.
Noémi Anna Nagy, Aram M de Haas, +4 authors, Esther C de Jong.
Front Immunol, 2021 Jun 01; 12. PMID: 34054859    Free PMC article.
High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation.
Laura Sibley, Andrew D White, +16 authors, Sally Sharpe.
Sci Rep, 2021 Jun 12; 11(1). PMID: 34112845    Free PMC article.
Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection.
Catherine Riou, Elsa du Bruyn, +12 authors, HIATUS consortium.
J Clin Invest, 2021 May 05; 131(12). PMID: 33945513    Free PMC article.
Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.
María Ailén Natale, Todd Minning, +9 authors, Susana Adriana Laucella.
PLoS Negl Trop Dis, 2021 Jun 02; 15(6). PMID: 34061845    Free PMC article.
Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults.
Aditya Arra, Maximilian Pech, +10 authors, Monika C Brunner-Weinzierl.
Oncoimmunology, 2021 Jun 29; 10(1). PMID: 34178430    Free PMC article.
Booster immunization with a fractional dose of Prevnar 13 affects cell-mediated immune response but not humoral immunity in CD-1 mice.
Rose-Marie Catalioto, Claudio Valenti, +5 authors, Stefania Meini.
Heliyon, 2021 Jul 02; 7(6). PMID: 34195422    Free PMC article.
Intranasal plus subcutaneous prime vaccination with a dual antigen COVID-19 vaccine elicits T-cell and antibody responses in mice.
Adrian Rice, Mohit Verma, +16 authors, Patrick Soon-Shiong.
Sci Rep, 2021 Jul 23; 11(1). PMID: 34290317    Free PMC article.
Comparison of Lethal and Nonlethal Mouse Models of Orientia tsutsugamushi Infection Reveals T-Cell Population-Associated Cytokine Signatures Correlated with Lethality and Protection.
Alison Luce-Fedrow, Suchismita Chattopadhyay, +3 authors, Allen L Richards.
Trop Med Infect Dis, 2021 Jul 22; 6(3). PMID: 34287349    Free PMC article.
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.
Pierre Tonnerre, David Wolski, +27 authors, Georg M Lauer.
Nat Immunol, 2021 Jul 28; 22(8). PMID: 34312544    Free PMC article.
Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology.
Sophie Steiner, Tatjana Schwarz, +6 authors, Leif G Hanitsch.
Front Immunol, 2021 Jul 30; 12. PMID: 34322120    Free PMC article.
Broad and Efficient Activation of Memory CD4+ T Cells by Novel HAdV- and HCMV-Derived Peptide Pools.
Alexander Höttler, Léo März, +2 authors, Stefan Stevanović.
Front Immunol, 2021 Jul 30; 12. PMID: 34322126    Free PMC article.
Variable immunogenicity of a vivax malaria blood-stage vaccine candidate.
Sai Lata De, Samuel May, +7 authors, John H Adams.
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The combined vaccination protocol of DNA/MVA expressing Zika virus structural proteins as efficient inducer of T and B cell immune responses.
Patricia Pérez, Miguel A Martín-Acebes, +5 authors, Juan García-Arriaza.
Emerg Microbes Infect, 2021 Jul 03; 10(1). PMID: 34213405    Free PMC article.
Interfacing Biomaterials with Synthetic T Cell Immunity.
Fang-Yi Su, Quoc D Mac, Anirudh Sivakumar, Gabriel A Kwong.
Adv Healthc Mater, 2021 Apr 23; 10(15). PMID: 33887123    Free PMC article.
Mycobacterium tuberculosis-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection.
Cheleka A M Mpande, Pia Steigler, +11 authors, Elisa Nemes.
Front Immunol, 2021 Sep 17; 12. PMID: 34526988    Free PMC article.
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients.
Jonathan Youngs, Nicholas M Provine, +32 authors, Tihana Bicanic.
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Association between circulating CD39+CD8+ T cells pre-chemoradiotherapy and prognosis in patients with nasopharyngeal carcinoma.
Dan-Ning Dong, Pei-Wen Fan, +5 authors, Jin-Ming Yu.
Chin Med J (Engl), 2021 Aug 27; 134(17). PMID: 34435978    Free PMC article.
Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection.
Hongyan Hou, Yandi Zhang, +10 authors, Feng Wang.
J Allergy Clin Immunol, 2021 Sep 19; 148(6). PMID: 34536418    Free PMC article.
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine.
Sonia Jangra, Jeffrey J Landers, +8 authors, Pamela T Wong.
Front Immunol, 2021 Oct 05; 12. PMID: 34603303    Free PMC article.
Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A.
Kristina Ritter, Jochen Behrends, +6 authors, Christoph Hölscher.
J Mol Med (Berl), 2021 Aug 06; 99(11). PMID: 34351501    Free PMC article.
Pandemic Preparedness Against Influenza: DNA Vaccine for Rapid Relief.
Tor Kristian Andersen, Johanna Bodin, +3 authors, Gunnveig Grødeland.
Front Immunol, 2021 Oct 26; 12. PMID: 34691056    Free PMC article.
Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques.
Hannah A D King, M Gordon Joyce, +54 authors, Diane L Bolton.
Proc Natl Acad Sci U S A, 2021 Sep 03; 118(38). PMID: 34470866    Free PMC article.
CD8+ T Cell Response Quality Is Related to Parasite Control in an Animal Model of Single and Mixed Chronic Trypanosoma cruzi Infections.
Jose Mateus, Paola Nocua, +7 authors, Adriana Cuéllar.
Front Cell Infect Microbiol, 2021 Oct 30; 11. PMID: 34712620    Free PMC article.
Immunotherapy With 5, 15-DPP Mediates Macrophage M1 Polarization and Modulates Subsequent Mycobacterium tuberculosis Infectivity in rBCG30 Immunized Mice.
Faraz Ahmad, Mohd Saad Umar, +5 authors, Mohammad Owais.
Front Immunol, 2021 Nov 16; 12. PMID: 34777338    Free PMC article.
Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines.
Trine Sundebo Meldgaard, Fabiola Blengio, +7 authors, Sylvie Bertholet.
Front Immunol, 2021 Nov 16; 12. PMID: 34777370    Free PMC article.
Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8High T Cells Are Associated With the Cure of Human Visceral Leishmaniasis.
Lorranny Santana Rodrigues, Aline Silva Barreto, +8 authors, Roque Pacheco de Almeida.
Front Immunol, 2021 Nov 16; 12. PMID: 34777391    Free PMC article.
Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma.
Catherine S Forconi, David H Mulama, +7 authors, Ann M Moormann.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771539    Free PMC article.
T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses.
Elahe Aleebrahim-Dehkordi, Bahareh Molavi, +7 authors, Ali Hasanpour-Dehkordi.
Transpl Immunol, 2021 Nov 15; 70. PMID: 34774738    Free PMC article.
An overview of multiplexed analyses of CAR T-cell therapies: insights and potential.
Brittany Paige DePriest, Noah Vieira, Alan Bidgoli, Sophie Paczesny.
Expert Rev Proteomics, 2021 Oct 12; 18(9). PMID: 34628995    Free PMC article.
Ensemble Machine Learning Model to Predict SARS-CoV-2 T-Cell Epitopes as Potential Vaccine Targets.
Syed Nisar Hussain Bukhari, Amit Jain, +2 authors, Julian Webber.
Diagnostics (Basel), 2021 Nov 28; 11(11). PMID: 34829338    Free PMC article.
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients.
Synne Jenum, Kristian Tonby, +11 authors, Anne Ma Dyrhol-Riise.
Nat Commun, 2021 Nov 24; 12(1). PMID: 34811370    Free PMC article.
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates.
Stéphane Pillet, Prabhu S Arunachalam, +20 authors, Brian J Ward.
Cell Mol Immunol, 2022 Jan 06; 19(2). PMID: 34983950    Free PMC article.
Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.
Damian A Oyong, Jessica R Loughland, +13 authors, Michelle J Boyle.
EBioMedicine, 2021 Dec 31; 75. PMID: 34968760    Free PMC article.
Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.
Nina Koerber, Alina Priller, +22 authors, Percy A Knolle.
Nat Commun, 2022 Jan 12; 13(1). PMID: 35013191    Free PMC article.
The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory.
Anjuman Ara, Aizhang Xu, +5 authors, Jim Xiang.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008461    Free PMC article.
Restoring the Balance between Pro-Inflammatory and Anti-Inflammatory Cytokines in the Treatment of Rheumatoid Arthritis: New Insights from Animal Models.
Adrienn Markovics, Ken S Rosenthal, +3 authors, Daniel H Zimmerman.
Biomedicines, 2022 Jan 22; 10(1). PMID: 35052724    Free PMC article.
Interleukin-27 in Tuberculosis: A Sheep in Wolf's Clothing?
Kristina Ritter, Jasmin Rousseau, Christoph Hölscher.
Front Immunol, 2022 Feb 05; 12. PMID: 35116036    Free PMC article.
Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal.
Yolanda Corripio-Miyar, Adam Hayward, +7 authors, Tom N McNeilly.
Sci Rep, 2022 Feb 26; 12(1). PMID: 35210503    Free PMC article.
Machine Learning Techniques for the Prediction of B-Cell and T-Cell Epitopes as Potential Vaccine Targets with a Specific Focus on SARS-CoV-2 Pathogen: A Review.
Syed Nisar Hussain Bukhari, Amit Jain, +2 authors, Julian Webber.
Pathogens, 2022 Feb 27; 11(2). PMID: 35215090    Free PMC article.
CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis.
Nan Zheng, Joy Fleming, +7 authors, Hongtai Zhang.
Microbiol Spectr, 2022 Feb 25; 10(1). PMID: 35196822    Free PMC article.
Longitudinal association of cytokine-producing CMV-specific T cells with frailty in HIV-infected and -uninfected men who have sex with men.
Weiying Zhang, Huifen Li, +3 authors, Joseph B Margolick.
Immun Ageing, 2022 Mar 09; 19(1). PMID: 35255947    Free PMC article.
Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection.
Matthew Zirui Tay, Angeline Rouers, +27 authors, Lisa Fp Ng.
EMBO Mol Med, 2022 Jan 08; 14(3). PMID: 34994081    Free PMC article.
Polymeric Systems for Cancer Immunotherapy: A Review.
Thai Minh Duy Le, A-Rum Yoon, Thavasyappan Thambi, Chae-Ok Yun.
Front Immunol, 2022 Mar 12; 13. PMID: 35273607    Free PMC article.
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients.
Xavier Charmetant, Maxime Espi, +20 authors, Olivier Thaunat.
Sci Transl Med, 2022 Feb 02; 14(636). PMID: 35103481    Free PMC article.
Mechanisms of cellular and humoral immunity through the lens of VLP-based vaccines.
Hunter McFall-Boegeman, Xuefei Huang.
Expert Rev Vaccines, 2022 Jan 14; 21(4). PMID: 35023430    Free PMC article.
Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.
Ida Laurén, Sebastian Havervall, +28 authors, Sara Mangsbo.
Immun Inflamm Dis, 2022 Mar 30; 10(4). PMID: 35349756    Free PMC article.
Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza.
Kunal Dhume, Caroline M Finn, +7 authors, Karl Kai McKinstry.
J Immunol, 2022 Mar 27; 208(8). PMID: 35338093    Free PMC article.
Adult Memory T Cell Responses to the Respiratory Syncytial Virus Fusion Protein During a Single RSV Season (2018-2019).
Brittani N Blunck, Laura S Angelo, +6 authors, Pedro A Piedra.
Front Immunol, 2022 Apr 16; 13. PMID: 35422803    Free PMC article.
Mycobacterium tuberculosis-Specific T-Cell Responses Are Impaired During Late Pregnancy With Elevated Biomarkers of Tuberculosis Risk Postpartum.
Aparajita Saha, Jaclyn Escuduero, +10 authors, Javeed A Shah.
J Infect Dis, 2021 Dec 21; 225(9). PMID: 34929030    Free PMC article.
In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals.
Li Li, Muharrem Muftuoglu, +7 authors, Simrit Parmar.
JCI Insight, 2022 Mar 02; 7(7). PMID: 35230977    Free PMC article.
Immune Response to Microsporidia.
Magali M Moretto, Imtiaz A Khan.
Exp Suppl, 2022 May 12; 114. PMID: 35544009
TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.
Kattria van der Ploeg, Adam S Kirosingh, +19 authors, Prasanna Jagannathan.
Cell Rep Med, 2022 May 20;. PMID: 35588734    Free PMC article.