Journal Article
. 2008 Apr; 3:17.
doi: 10.1186/1746-1596-3-17.

Image standards in tissue-based diagnosis (diagnostic surgical pathology)

Klaus Kayser 1 Jürgen Görtler  Torsten Goldmann  Ekkehard Vollmer  Peter Hufnagl  Gian Kayser  
Affiliations
  • PMID: 18423031
  •     65 References
  •     19 citations

Abstract

Background: Progress in automated image analysis, virtual microscopy, hospital information systems, and interdisciplinary data exchange require image standards to be applied in tissue-based diagnosis.

Aims: To describe the theoretical background, practical experiences and comparable solutions in other medical fields to promote image standards applicable for diagnostic pathology. THEORY AND EXPERIENCES: Images used in tissue-based diagnosis present with pathology-specific characteristics. It seems appropriate to discuss their characteristics and potential standardization in relation to the levels of hierarchy in which they appear. All levels can be divided into legal, medical, and technological properties. Standards applied to the first level include regulations or aims to be fulfilled. In legal properties, they have to regulate features of privacy, image documentation, transmission, and presentation; in medical properties, features of disease-image combination, human-diagnostics, automated information extraction, archive retrieval and access; and in technological properties features of image acquisition, display, formats, transfer speed, safety, and system dynamics. The next lower second level has to implement the prescriptions of the upper one, i.e. describe how they are implemented. Legal aspects should demand secure encryption for privacy of all patient related data, image archives that include all images used for diagnostics for a period of 10 years at minimum, accurate annotations of dates and viewing, and precise hardware and software information. Medical aspects should demand standardized patients' files such as DICOM 3 or HL 7 including history and previous examinations, information of image display hardware and software, of image resolution and fields of view, of relation between sizes of biological objects and image sizes, and of access to archives and retrieval. Technological aspects should deal with image acquisition systems (resolution, colour temperature, focus, brightness, and quality evaluation procedures), display resolution data, implemented image formats, storage, cycle frequency, backup procedures, operation system, and external system accessibility. The lowest third level describes the permitted limits and threshold in detail. At present, an applicable standard including all mentioned features does not exist to our knowledge; some aspects can be taken from radiological standards (PACS, DICOM 3); others require specific solutions or are not covered yet.

Conclusion: The progress in virtual microscopy and application of artificial intelligence (AI) in tissue-based diagnosis demands fast preparation and implementation of an internationally acceptable standard. The described hierarchic order as well as analytic investigation in all potentially necessary aspects and details offers an appropriate tool to specifically determine standardized requirements.

Effect of image compression on telepathology. A randomized clinical trial.
A Marcelo, P Fontelo, M Farolan, H Cualing.
Arch Pathol Lab Med, 2000 Nov 18; 124(11). PMID: 11079019
Robotic telepathology: efficacy and usability in pulmonary pathology.
F J W-M Leong, A G Nicholson, J O'D McGee.
J Pathol, 2002 May 17; 197(2). PMID: 12015745
Store-and-forward diagnostic telepathology of small biopsies by e-mail attachment: a feasibility pilot study with a view for future application in Thailand diagnostic pathology services.
J Settakorn, T Kuakpaetoon, +2 authors, K Ichijima.
Telemed J E Health, 2002 Nov 07; 8(3). PMID: 12419027
Standardization and quality control of quantitative microscopy in pathology.
R L Becker.
J Cell Biochem Suppl, 1993 Jan 01; 17G. PMID: 8007698
Towards an automated virtual slide screening: theoretical considerations and practical experiences of automated tissue-based virtual diagnosis to be implemented in the Internet.
Klaus Kayser, Dominik Radziszowski, +2 authors, Gian Kayser.
Diagn Pathol, 2006 Jun 13; 1. PMID: 16764733    Free PMC article.
Digital imaging in pathology: the case for standardization.
Yukako Yagi, John R Gilbertson.
J Telemed Telecare, 2005 May 20; 11(3). PMID: 15901437
Society of Toxicologic Pathology position paper on pathology image data: compliance with 21 CFR Parts 58 and 11.
Darrell L Tuomari, Ramon K Kemp, +6 authors, Society of Toxicologic Pathology.
Toxicol Pathol, 2007 May 03; 35(3). PMID: 17474067
An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study.
Ronald S Weinstein, Michael R Descour, +15 authors, Peter H Bartels.
Hum Pathol, 2005 Jan 26; 35(11). PMID: 15668886
Telepathology with an integrated services digital network--a new tool for image transfer in surgical pathology: a preliminary report.
M Oberholzer, H R Fischer, +7 authors, L Bächthold.
Hum Pathol, 1993 Oct 01; 24(10). PMID: 8406418
Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go?
M D Smith, D Baeten, +6 authors, OMERACT synovial special interests group.
Ann Rheum Dis, 2005 Jun 25; 65(1). PMID: 15975970    Free PMC article.
Review.
Digital pathology: DICOM-conform draft, testbed, and first results.
Ralf Zwönitzer, Thomas Kalinski, +2 authors, Johannes Bernarding.
Comput Methods Programs Biomed, 2007 Jul 10; 87(3). PMID: 17618703
Digital photography: a primer for pathologists.
Roger S Riley, Jonathan M Ben-Ezra, +2 authors, Gina Romagnoli.
J Clin Lab Anal, 2004 Apr 06; 18(2). PMID: 15065212    Free PMC article.
Review.
Telepathology in Europe. Its practical use.
K Kayser.
Arch Anat Cytol Pathol, 1995 Jan 01; 43(4). PMID: 8526551
Diagnostic architectural and dynamic features at breast MR imaging: multicenter study.
Mitchell D Schnall, Jeffrey Blume, +14 authors, Constantine A Gatsonis.
Radiology, 2005 Dec 24; 238(1). PMID: 16373758
Highly Cited.
A new approach to the validation of tissue microarrays.
L Goethals, C Perneel, +6 authors, K M Haustermans.
J Pathol, 2006 Jan 26; 208(5). PMID: 16435284
Strategies for efficient virtual microscopy in pathological samples using JPEG2000.
Marcela Iregui, Francisco Gómez, Eduardo Romero.
Micron, 2007 Jun 29; 38(7). PMID: 17596952
[Virtual microscopy: first applications].
K Glatz-Krieger, D Glatz, M J Mihatsch.
Pathologe, 2005 Aug 13; 27(6). PMID: 16096757
Review.
The use of digital 'virtual slides' in the quality assessment of haematological morphology: results of a pilot exercise involving UK NEQAS(H) participants.
J Burthem, M Brereton, +9 authors, K Hyde.
Br J Haematol, 2005 Jul 21; 130(2). PMID: 16029459
DNA histogram interpretation based on statistical approaches.
G Haroske, V Dimmer, W Meyer, K D Kunze.
Anal Cell Pathol, 1997 Jan 01; 15(3). PMID: 9497853    Free PMC article.
Telecommunication--a new tool for quality assurance and control in diagnostic pathology.
K Kayser, M Beyer, S Blum, G Kayser.
Folia Neuropathol, 2000 Nov 01; 38(2). PMID: 11057040
Compression guidelines for diagnostic telepathology.
D J Foran, P P Meer, T Papathomas, I Marsic.
IEEE Trans Inf Technol Biomed, 1997 Mar 01; 1(1). PMID: 11020810
Refining DICOM for pathology--progress from the IHE and DICOM pathology working groups.
Christel Le Bozec, Dominique Henin, +3 authors, Bruce Beckwith.
Stud Health Technol Inform, 2007 Oct 04; 129(Pt 1). PMID: 17911754
The application of the MPEG-4 standard to telepathology images for electronic patient records.
Georg A Brox, Janis L Huston.
J Telemed Telecare, 2003 Sep 04; 9 Suppl 1. PMID: 12952709
Digital storage of glass slides for quality assurance in histopathology and cytopathology.
Francesca Demichelis, Vincenzo Della Mea, +2 authors, Carlo Alberto Beltrami.
J Telemed Telecare, 2002 Jul 05; 8(3). PMID: 12097174
Review.
Interlaboratory comparison of DNA image analysis. Management group report of internal quality assurance programme in the CAAC breast cancer project.
F B Thunnissen, I O Ellis, U Jütting, G Burger.
Zentralbl Pathol, 1994 Feb 01; 139(6). PMID: 7512823
A telepathology based Virtual Reference and Certification Centre for DNA image cytometry.
G Haroske, F Giroud, K D Kunze, W Meyer.
Anal Cell Pathol, 2001 May 08; 21(3-4). PMID: 11339562    Free PMC article.
Review.
The diagnostic path, a useful visualisation tool in virtual microscopy.
Thomas Schrader, Sonja Niepage, +5 authors, Manfred Dietel.
Diagn Pathol, 2006 Nov 10; 1. PMID: 17092352    Free PMC article.
Quality assessment of genetic markers used for therapy stratification.
I M Ambros, J Benard, +30 authors, P F Ambros.
J Clin Oncol, 2003 May 31; 21(11). PMID: 12775732
The current status of breast MR imaging. Part I. Choice of technique, image interpretation, diagnostic accuracy, and transfer to clinical practice.
Christiane Kuhl.
Radiology, 2007 Jul 21; 244(2). PMID: 17641361
Highly Cited. Review.
Standardisation of DNA quantitation by image analysis: quality control of instrumentation.
M Puech, F Giroud.
Cytometry, 1999 May 20; 36(1). PMID: 10331622
Image dissemination and archiving.
Ian Robertson.
Clin Tech Small Anim Pract, 2007 Sep 12; 22(3). PMID: 17844820
Review.
Signal analysis and compression performance evaluation of pathological microscopic images.
A Okumura, J Suzuki, +2 authors, T Ashihara.
IEEE Trans Med Imaging, 1998 Apr 09; 16(6). PMID: 9533571
Digitized pathology: theory and experiences in automated tissue-based virtual diagnosis.
K Kayser, D Radziszowski, +2 authors, G Kayser.
Rom J Morphol Embryol, 2006 Jul 14; 47(1). PMID: 16838053
Histopathology and the 'third great lie'. When is an image not a scientifically authentic image?
S K Suvarna, M A Ansary.
Histopathology, 2001 Dec 12; 39(5). PMID: 11737300
Review.
Large image microscope array for the compilation of multimodality whole organ image databases.
Eman Namati, Jessica De Ryk, +3 authors, Geoffrey Mclennan.
Anat Rec (Hoboken), 2007 Sep 14; 290(11). PMID: 17853414
Automated screening for cervical cancer: diagnostic decision procedures.
P H Bartels, G L Wied.
Acta Cytol, 1997 Jan 01; 41(1). PMID: 9022719
The UICC Telepathology Consultation Center. International Union Against Cancer. A global approach to improving consultation for pathologists in cancer diagnosis.
M Dietel, T N Nguyen-Dobinsky, P Hufnagl.
Cancer, 2000 Jul 18; 89(1). PMID: 10897017
The framework of pathology: good laboratory practice by quantitative and molecular methods.
Jan P A Baak.
J Pathol, 2002 Oct 11; 198(3). PMID: 12375259
Review.
Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slides.
Gian Kayser, Dominik Radziszowski, +2 authors, Klaus Kayser.
Anal Quant Cytol Histol, 2006 Mar 29; 28(1). PMID: 16566277
[Small but high throughput: how "tissue-microarrays" became a favorite tool for pathologists and scientists].
Jocelyne Jacquemier, Christophe Ginestier, +4 authors, Daniel Birnbaum.
Ann Pathol, 2004 Apr 20; 23(6). PMID: 15094604
A European de facto standard for image folders applied to telepathology and teaching.
J Klossa, J C Cordier, +2 authors, J Hémet.
Int J Med Inform, 1998 May 26; 48(1-3). PMID: 9600422
Applications of virtual reality technology in pathology.
G J Grimes, S A McClellan, +6 authors, W Fleming.
Stud Health Technol Inform, 1996 Dec 08; 39. PMID: 10168927
Texture- and object-related automated information analysis in histological still images of various organs.
Klaus Kayser, Sabah Amir Hoshang, +6 authors, Gian Kayser.
Anal Quant Cytol Histol, 2009 Jan 24; 30(6). PMID: 19160697
Teleconsultation in diagnostic pathology: experience from Iran and Germany with the use of two European telepathology servers.
Masoud Mireskandari, Gian Kayser, +2 authors, Klaus Kayser.
J Telemed Telecare, 2004 Apr 08; 10(2). PMID: 15068646
Guidelines from the European Society of Breast Imaging for diagnostic interventional breast procedures.
Matthew Wallis, Anne Tardivon, +3 authors, European Society of Breast Imaging.
Eur Radiol, 2006 Oct 03; 17(2). PMID: 17013595
Review.
Introducing Diagnostic Pathology.
Klaus Kayser.
Diagn Pathol, 2006 Jun 09; 1. PMID: 16759425    Free PMC article.
Fastest is always best and other PACS fallacies.
M Cannavo.
Health Manag Technol, 1995 Oct 05; 16(12). PMID: 10152756
Digital slide and virtual microscopy based routine and telepathology evaluation of routine gastrointestinal biopsy specimens.
B Molnar, L Berczi, +4 authors, Z Tulassay.
J Clin Pathol, 2003 Jun 05; 56(6). PMID: 12783970    Free PMC article.
Validation of novel optical imaging technologies: the pathologists' view.
Wendy A Wells, Peter E Barker, +3 authors, James M Crawford.
J Biomed Opt, 2007 Nov 13; 12(5). PMID: 17994879
Review.
Quality control for digital mammography in the ACRIN DMIST trial: part I.
Aili K Bloomquist, Martin J Yaffe, +12 authors, J A Seibert.
Med Phys, 2006 Aug 02; 33(3). PMID: 16878575
Grid technology in tissue-based diagnosis: fundamentals and potential developments.
Jürgen Görtler, Martin Berghoff, Gian Kayser, Klaus Kayser.
Diagn Pathol, 2006 Aug 26; 1. PMID: 16930477    Free PMC article.
JPEG compression of stereoscopic digital images for the diagnosis of diabetic retinopathy via teleophthalmology.
Chad F Baker, Christopher J Rudnisky, +4 authors, Mark D J Greve.
Can J Ophthalmol, 2005 Feb 09; 39(7). PMID: 15696764
Digital imagery/telecytology. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.
M J O'Brien, M Takahashi, +14 authors, C Winkler.
Acta Cytol, 1998 Feb 28; 42(1). PMID: 9479334
Review.
Increase of precision and accuracy of DNA cytometry by correcting diffraction and glare errors.
G Haroske, W Meyer, F Theissig, K D Kunze.
Anal Cell Pathol, 1995 Jul 01; 9(1). PMID: 7577750
Digital image documentation for quality assessment.
D Cruz, C Valentí, +2 authors, F Schmitt.
Arch Pathol Lab Med, 2001 Nov 08; 125(11). PMID: 11697997
Basic aspects of and recent developments in telepathology in Europe, with specific emphasis on quality assurance.
K Kayser, G Kayser.
Anal Quant Cytol Histol, 1999 Nov 24; 21(4). PMID: 10560509
Review.
Competence on demand in DNA image cytometry.
G Haroske, W Meyer, +2 authors, K D Kunze.
Pathol Res Pract, 2000 Jun 02; 196(5). PMID: 10834384
Review.
Analysis of the reliability of manual and automated immunohistochemical staining procedures. A pilot study.
Stefan Biesterfeld, Helen Louise Kraus, +3 authors, Christian Rudlowski.
Anal Quant Cytol Histol, 2003 May 16; 25(2). PMID: 12746978
Quantitative analysis of estrogen receptor heterogeneity in breast cancer.
Gina G Chung, Maciej P Zerkowski, +2 authors, David L Rimm.
Lab Invest, 2007 Mar 06; 87(7). PMID: 17334408
Aspects of standardization in telepathology.
K Kayser, P Schwarzmann.
Zentralbl Pathol, 1992 Dec 01; 138(6). PMID: 1297428
Development, standardization, and testing of a lexicon for reporting contrast-enhanced breast magnetic resonance imaging studies.
D M Ikeda, N M Hylton, +9 authors, M D Schnall.
J Magn Reson Imaging, 2001 May 31; 13(6). PMID: 11382949
How technology is reshaping the practice of nongynecologic cytology: frontiers of cytology symposium.
Marluce Bibbo.
Acta Cytol, 2007 Apr 12; 51(2). PMID: 17425194
Quantitative histopathological analysis of cervical intra-epithelial neoplasia sections: methodological issues.
Martial Guillaud, Dennis Cox, +7 authors, Calum MacAulay.
Cell Oncol, 2004 Sep 17; 26(1-2). PMID: 15371655    Free PMC article.
Image quality issues in a static image-based telepathology consultation practice.
Bruce H Williams, In Soon Hong, +3 authors, Timothy J O'Leary.
Hum Pathol, 2003 Dec 24; 34(12). PMID: 14691906
HIS/RIS/PACS integration: getting to the gold standard.
Stephen S Boochever.
Radiol Manage, 2004 Jul 21; 26(3). PMID: 15259683
How do surgical pathologists evaluate critical diagnoses (critical values)?
Masoud Mireskandari.
Diagn Pathol, 2008 Jul 16; 3. PMID: 18620590    Free PMC article.
Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process.
Stephan Wienert, Michael Beil, +2 authors, Thomas Schrader.
Diagn Pathol, 2009 Jan 13; 4. PMID: 19134181    Free PMC article.
Theory of sampling and its application in tissue based diagnosis.
Klaus Kayser, Holger Schultz, +3 authors, Ekkehard Vollmer.
Diagn Pathol, 2009 Feb 18; 4. PMID: 19220904    Free PMC article.
A European network for virtual microscopy--design, implementation and evaluation of performance.
Mikael Lundin, Janusz Szymas, +11 authors, Johan Lundin.
Virchows Arch, 2009 Mar 13; 454(4). PMID: 19280223
Linking whole-slide microscope images with DICOM by using JPEG2000 interactive protocol.
Vilppu J Tuominen, Jorma Isola.
J Digit Imaging, 2009 May 06; 23(4). PMID: 19415383    Free PMC article.
Using a visual discrimination model for the detection of compression artifacts in virtual pathology images.
Jeffrey P Johnson, Elizabeth A Krupinski, +3 authors, Ronald S Weinstein.
IEEE Trans Med Imaging, 2010 Sep 30; 30(2). PMID: 20875970    Free PMC article.
Technical note on the validation of a semi-automated image analysis software application for estrogen and progesterone receptor detection in breast cancer.
László Krecsák, Tamás Micsik, +8 authors, Béla Molnár.
Diagn Pathol, 2011 Jan 20; 6. PMID: 21244664    Free PMC article.
A supervised visual model for finding regions of interest in basal cell carcinoma images.
Ricardo Gutiérrez, Francisco Gómez, Lucía Roa-Peña, Eduardo Romero.
Diagn Pathol, 2011 Mar 31; 6. PMID: 21447178    Free PMC article.
Optimizing automated characterization of liver fibrosis histological images by investigating color spaces at different resolutions.
Doaa Mahmoud-Ghoneim.
Theor Biol Med Model, 2011 Jul 16; 8. PMID: 21756305    Free PMC article.
History and structures of telecommunication in pathology, focusing on open access platforms.
Klaus Kayser, Stephan Borkenfeld, Amina Djenouni, Gian Kayser.
Diagn Pathol, 2011 Nov 09; 6. PMID: 22059444    Free PMC article.
Validation of diagnostic accuracy using digital slides in routine histopathology.
László Fónyad, Tibor Krenács, +7 authors, Béla Molnár.
Diagn Pathol, 2012 Apr 03; 7. PMID: 22463804    Free PMC article.
Nuclear image analysis study of neuroendocrine tumors.
Meeja Park, Taehwa Baek, +4 authors, Hyekyung Lee.
Korean J Pathol, 2012 Oct 31; 46(1). PMID: 23109976    Free PMC article.
Validation of a new classifier for the automated analysis of the human epidermal growth factor receptor 2 (HER2) gene amplification in breast cancer specimens.
Daniela Furrer, Simon Jacob, +3 authors, Caroline Diorio.
Diagn Pathol, 2013 Feb 06; 8. PMID: 23379971    Free PMC article.
Validation of various adaptive threshold methods of segmentation applied to follicular lymphoma digital images stained with 3,3'-Diaminobenzidine&Haematoxylin.
Anna Korzynska, Lukasz Roszkowiak, +3 authors, Marylene Lejeune.
Diagn Pathol, 2013 Mar 28; 8. PMID: 23531405    Free PMC article.
The history of pathology informatics: A global perspective.
Seung Park, Anil V Parwani, +15 authors, Liron Pantanowitz.
J Pathol Inform, 2013 Jul 23; 4. PMID: 23869286    Free PMC article.
Quantitative imaging with a mobile phone microscope.
Arunan Skandarajah, Clay D Reber, Neil A Switz, Daniel A Fletcher.
PLoS One, 2014 May 16; 9(5). PMID: 24824072    Free PMC article.
Difference of the Nuclear Green Light Intensity between Papillary Carcinoma Cells Showing Clear Nuclei and Non-neoplastic Follicular Epithelia in Papillary Thyroid Carcinoma.
Hyekyung Lee, Tae Hwa Baek, +5 authors, Soo Young Kim.
J Pathol Transl Med, 2016 Aug 24; 50(5). PMID: 27550048    Free PMC article.
Deep Learning- and Transfer Learning-Based Super Resolution Reconstruction from Single Medical Image.
YiNan Zhang, MingQiang An.
J Healthc Eng, 2017 Oct 27; 2017. PMID: 29065625    Free PMC article.
Digital Microscopy, Image Analysis, and Virtual Slide Repository.
Famke Aeffner, Hibret A Adissu, +8 authors, Kristin Wilson.
ILAR J, 2018 Dec 12; 59(1). PMID: 30535284    Free PMC article.