Journal Article
. 2008 Oct; 322(5899):271-5.
doi: 10.1126/science.1160062.

CTLA-4 control over Foxp3+ regulatory T cell function

Kajsa Wing 1 Yasushi Onishi  Paz Prieto-Martin  Tomoyuki Yamaguchi  Makoto Miyara  Zoltan Fehervari  Takashi Nomura  Shimon Sakaguchi  
Affiliations
  • PMID: 18845758
  •     1185 citations

Abstract

Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell-mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice, and it also produces potent tumor immunity. Treg-specific CTLA-4 deficiency impairs in vivo and in vitro suppressive function of Tregs-in particular, Treg-mediated down-regulation of CD80 and CD86 expression on dendritic cells. Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells.

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Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
Trevor D Burt, Lillian Seu, +2 authors, Joseph M McCune.
J Immunol, 2010 Oct 06; 185(9). PMID: 20921523    Free PMC article.
Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice.
Inês Antunes, George Kassiotis.
J Virol, 2010 Oct 15; 84(24). PMID: 20943986    Free PMC article.
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
Tessy Iype, Mohan Sankarshanan, +2 authors, Ulrike Lorenz.
J Immunol, 2010 Oct 19; 185(10). PMID: 20952680    Free PMC article.
Tumor-infiltrating lymphocytes and hepatocellular carcinoma: pathology and clinical management.
Ken Shirabe, Takashi Motomura, +10 authors, Yoshihiko Maehara.
Int J Clin Oncol, 2010 Oct 22; 15(6). PMID: 20963618
Review.
Co-stimulation blockade as a new strategy in kidney transplantation: benefits and limits.
Renaud Snanoudj, Julien Zuber, Christophe Legendre.
Drugs, 2010 Oct 23; 70(16). PMID: 20964456
Review.
Clues to immune tolerance: the monogenic autoimmune syndromes.
Michael Waterfield, Mark S Anderson.
Ann N Y Acad Sci, 2010 Oct 26; 1214. PMID: 20969580    Free PMC article.
Review.
T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics.
Yael S Barach, Jun Sik Lee, Xingxing Zang.
Trends Mol Med, 2010 Oct 26; 17(1). PMID: 20971039    Free PMC article.
Review.
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
Luke Barron, Hans Dooms, +4 authors, Abul K Abbas.
J Immunol, 2010 Nov 03; 185(11). PMID: 21037099    Free PMC article.
Highly Cited.
Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells.
Zhonghua Yan, Sanjay K Garg, Ruma Banerjee.
J Biol Chem, 2010 Nov 03; 285(53). PMID: 21037289    Free PMC article.
Immunology: Conditional stability of T cells.
Shimon Sakaguchi.
Nature, 2010 Nov 05; 468(7320). PMID: 21048753
Minimal change disease: a "two-hit" podocyte immune disorder?
Michiko Shimada, Carlos Araya, +3 authors, Eduardo H Garin.
Pediatr Nephrol, 2010 Nov 06; 26(4). PMID: 21052729
Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis.
Stewart T G Burgess, David Frew, +4 authors, John F Huntley.
BMC Genomics, 2010 Nov 12; 11. PMID: 21067579    Free PMC article.
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.
Margaret K Callahan, Jedd D Wolchok, James P Allison.
Semin Oncol, 2010 Nov 16; 37(5). PMID: 21074063    Free PMC article.
Review.
3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance.
Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami.
Int Immunopharmacol, 2010 Nov 19; 11(5). PMID: 21084064    Free PMC article.
Review.
CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
Ashraful Haque, Shannon E Best, +6 authors, Christian R Engwerda.
PLoS Pathog, 2010 Dec 21; 6(12). PMID: 21170302    Free PMC article.
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Virginia A Pedicord, Welby Montalvo, Ingrid M Leiner, James P Allison.
Proc Natl Acad Sci U S A, 2010 Dec 22; 108(1). PMID: 21173239    Free PMC article.
Therapeutic cancer vaccines: are we there yet?
Christopher A Klebanoff, Nicolas Acquavella, Zhiya Yu, Nicholas P Restifo.
Immunol Rev, 2011 Jan 05; 239(1). PMID: 21198663    Free PMC article.
Highly Cited. Review.
Cellular response to mycobacteria: balancing protection and pathology.
Egídio Torrado, Richard T Robinson, Andrea M Cooper.
Trends Immunol, 2011 Jan 11; 32(2). PMID: 21216195    Free PMC article.
Review.
Phenotypical and functional specialization of FOXP3+ regulatory T cells.
Daniel J Campbell, Meghan A Koch.
Nat Rev Immunol, 2011 Jan 27; 11(2). PMID: 21267013    Free PMC article.
Highly Cited. Review.
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.
Taku Okazaki, Il-mi Okazaki, +9 authors, Tasuku Honjo.
J Exp Med, 2011 Feb 09; 208(2). PMID: 21300912    Free PMC article.
Genetic susceptibility to autoimmune liver disease.
Jochen Mattner.
World J Hepatol, 2011 Feb 11; 3(1). PMID: 21307981    Free PMC article.
The consequence of immune suppressive cells in the use of therapeutic cancer vaccines and their importance in immune monitoring.
Matteo Vergati, Jeffrey Schlom, Kwong Y Tsang.
J Biomed Biotechnol, 2011 Feb 15; 2011. PMID: 21318157    Free PMC article.
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.
Yorifumi Satou, Jun-Ichirou Yasunaga, +11 authors, Masao Matsuoka.
PLoS Pathog, 2011 Feb 25; 7(2). PMID: 21347344    Free PMC article.
Highly Cited.
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.
Erika Cretney, Annie Xin, +8 authors, Axel Kallies.
Nat Immunol, 2011 Mar 08; 12(4). PMID: 21378976
Highly Cited.
Whole recombinant yeast vaccine induces antitumor immunity and improves survival in a genetically engineered mouse model of melanoma.
A Tanaka, J D Jensen, +6 authors, M Fujita.
Gene Ther, 2011 Mar 11; 18(8). PMID: 21390072    Free PMC article.
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
Daniel T Patton, Marcus D Wilson, +2 authors, Klaus Okkenhaug.
PLoS One, 2011 Mar 11; 6(3). PMID: 21390257    Free PMC article.
Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells.
V Di Caro, A D'Anneo, +6 authors, N Giannoukakis.
Clin Exp Immunol, 2011 Mar 19; 165(1). PMID: 21413939    Free PMC article.
Tolerance in clinical transplantation: progress, challenge or just a dream?
Fred Fändrich.
Langenbecks Arch Surg, 2011 Mar 19; 396(4). PMID: 21416128
Review.
Initiation and regulation of T-cell responses in tuberculosis.
K B Urdahl, S Shafiani, J D Ernst.
Mucosal Immunol, 2011 Apr 01; 4(3). PMID: 21451503    Free PMC article.
Review.
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Omar S Qureshi, Yong Zheng, +12 authors, David M Sansom.
Science, 2011 Apr 09; 332(6029). PMID: 21474713    Free PMC article.
Highly Cited.
Co-inhibitory molecules: Controlling the effectors or controlling the controllers?
Govindarajan Thangavelu, Christa Smolarchuk, Colin C Anderson.
Self Nonself, 2011 Apr 14; 1(2). PMID: 21487510    Free PMC article.
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Sergio A Quezada, Karl S Peggs, Tyler R Simpson, James P Allison.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488893    Free PMC article.
Highly Cited. Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
Oral tolerance.
Howard L Weiner, Andre Pires da Cunha, Francisco Quintana, Henry Wu.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488901    Free PMC article.
Highly Cited. Review.
Cell surface signaling molecules in the control of immune responses: a tide model.
Yuwen Zhu, Sheng Yao, Lieping Chen.
Immunity, 2011 Apr 23; 34(4). PMID: 21511182    Free PMC article.
Review.
A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice.
Anna Morena D'Alise, Ayla Ergun, +2 authors, Christophe Benoist.
Proc Natl Acad Sci U S A, 2011 May 06; 108(21). PMID: 21543717    Free PMC article.
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
Michael A Curran, Myoungjoo Kim, +2 authors, James P Allison.
PLoS One, 2011 May 12; 6(4). PMID: 21559358    Free PMC article.
Highly Cited.
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.
Kay D Gerold, Peilin Zheng, +3 authors, Stephan Kissler.
Diabetes, 2011 May 24; 60(7). PMID: 21602513    Free PMC article.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
Regulatory T cells: stability revisited.
Samantha L Bailey-Bucktrout, Jeffrey A Bluestone.
Trends Immunol, 2011 May 31; 32(7). PMID: 21620768    Free PMC article.
The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells.
Xin Chen, Joost J Oppenheim.
Immunology, 2011 Jun 03; 133(4). PMID: 21631498    Free PMC article.
Review.
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Xin Chen, Joost J Oppenheim.
Int Immunopharmacol, 2011 Jun 04; 11(10). PMID: 21635972    Free PMC article.
Review.
Connexin 43 signaling enhances the generation of Foxp3+ regulatory T cells.
Michal Kuczma, Jeffrey R Lee, Piotr Kraj.
J Immunol, 2011 Jun 07; 187(1). PMID: 21642545    Free PMC article.
Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection.
Jason P Gigley, Imtiaz A Khan.
PLoS One, 2011 Jun 23; 6(6). PMID: 21695169    Free PMC article.
Induction of self-antigen-specific Foxp3+ regulatory T cells in the periphery by lymphodepletion treatment with anti-mouse thymocyte globulin in mice.
Yan Lu, Jun Suzuki, +2 authors, Zhibin Chen.
Immunology, 2011 Jun 30; 134(1). PMID: 21711461    Free PMC article.
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Lei Tian, John A Altin, +5 authors, Adrian Liston.
Blood, 2011 Jul 01; 118(7). PMID: 21715314    Free PMC article.
Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human.
Fabian Birzele, Tanja Fauti, +6 authors, Detlev Mennerich.
Nucleic Acids Res, 2011 Jul 07; 39(18). PMID: 21729870    Free PMC article.
PKC-θ function at the immunological synapse: prospects for therapeutic targeting.
Alexandra Zanin-Zhorov, Michael L Dustin, Bruce R Blazar.
Trends Immunol, 2011 Jul 08; 32(8). PMID: 21733754    Free PMC article.
Review.
Regulatory T cells for tolerance therapy: revisiting the concept.
Christian Leguern.
Crit Rev Immunol, 2011 Jul 12; 31(3). PMID: 21740350    Free PMC article.
Review.
Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner.
T Zhang, S Fresnay, +11 authors, A M Azimzadeh.
Am J Transplant, 2011 Jul 14; 11(8). PMID: 21749640    Free PMC article.
Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens.
Jared H Rowe, James M Ertelt, +2 authors, Sing Sing Way.
Cell Host Microbe, 2011 Jul 20; 10(1). PMID: 21767812    Free PMC article.
Cooperative regulation of NOTCH1 protein-phosphatidylinositol 3-kinase (PI3K) signaling by NOD1, NOD2, and TLR2 receptors renders enhanced refractoriness to transforming growth factor-beta (TGF-beta)- or cytotoxic T-lymphocyte antigen 4 (CTLA-4)-mediated impairment of human dendritic cell maturation.
Devram Sampat Ghorpade, Srini V Kaveri, Jagadeesh Bayry, Kithiganahalli Narayanaswamy Balaji.
J Biol Chem, 2011 Jul 20; 286(36). PMID: 21768114    Free PMC article.
Foxp3+ follicular regulatory T cells control the germinal center response.
Michelle A Linterman, Wim Pierson, +11 authors, Carola G Vinuesa.
Nat Med, 2011 Jul 26; 17(8). PMID: 21785433    Free PMC article.
Highly Cited.
Opposing functions of IL-2 and IL-7 in the regulation of immune responses.
Shoshana D Katzman, Katrina K Hoyer, +5 authors, Abul K Abbas.
Cytokine, 2011 Aug 03; 56(1). PMID: 21807532    Free PMC article.
Review.
Clinical perspectives for regulatory T cells in transplantation tolerance.
Keli L Hippen, James L Riley, Carl H June, Bruce R Blazar.
Semin Immunol, 2011 Aug 09; 23(6). PMID: 21820917    Free PMC article.
Review.
Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.
Wolfgang Kastenmuller, Georg Gasteiger, +5 authors, Ronald N Germain.
J Immunol, 2011 Aug 19; 187(6). PMID: 21849683    Free PMC article.
Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization.
Qibo Zhang, Samuel C Leong, +3 authors, Adam Finn.
PLoS Pathog, 2011 Aug 20; 7(8). PMID: 21852948    Free PMC article.
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production.
Reiko Takahashi, Shuhei Nishimoto, +7 authors, Akihiko Yoshimura.
J Exp Med, 2011 Sep 07; 208(10). PMID: 21893603    Free PMC article.
Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.
Pedro Morgado, Yi-Ching Ong, John C Boothroyd, Melissa B Lodoen.
Infect Immun, 2011 Sep 14; 79(11). PMID: 21911468    Free PMC article.
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
Paul A Beavis, Bernard Gregory, +6 authors, Fionula M Brennan.
Proc Natl Acad Sci U S A, 2011 Sep 20; 108(40). PMID: 21926327    Free PMC article.
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Hardis Rabe, Anna-Carin Lundell, +3 authors, Anna Rudin.
J Leukoc Biol, 2011 Sep 22; 90(6). PMID: 21934066    Free PMC article.
Beyond cancer vaccines: a reason for future optimism with immunomodulatory therapy.
Michael Postow, Margaret K Callahan, Jedd D Wolchok.
Cancer J, 2011 Sep 29; 17(5). PMID: 21952288    Free PMC article.
Review.
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.
Elizabeth A Wohlfert, John R Grainger, +14 authors, Yasmine Belkaid.
J Clin Invest, 2011 Oct 04; 121(11). PMID: 21965331    Free PMC article.
Highly Cited.
Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells.
Min Chen, Kumar Felix, Jin Wang.
J Immunol, 2011 Oct 28; 187(11). PMID: 22031758    Free PMC article.
Immune recovery after cyclophosphamide treatment in multiple myeloma: implication for maintenance immunotherapy.
Amir Sharabi, Nechama Haran-Ghera.
Bone Marrow Res, 2011 Nov 03; 2011. PMID: 22046558    Free PMC article.
Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma.
Xiang-Yang Wang, Daming Zuo, Devanand Sarkar, Paul B Fisher.
Expert Opin Pharmacother, 2011 Nov 15; 12(17). PMID: 22077831    Free PMC article.
Review.
Regulatory T cells and IL-10 independently counterregulate cytotoxic T lymphocyte responses induced by transcutaneous immunization.
Pamela Stein, Michael Weber, +7 authors, Markus P Radsak.
PLoS One, 2011 Nov 25; 6(11). PMID: 22114725    Free PMC article.
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Lucy S K Walker, David M Sansom.
Nat Rev Immunol, 2011 Nov 26; 11(12). PMID: 22116087
Highly Cited.
Response to self antigen imprints regulatory memory in tissues.
Michael D Rosenblum, Iris K Gratz, +3 authors, Abul K Abbas.
Nature, 2011 Nov 29; 480(7378). PMID: 22121024    Free PMC article.
Highly Cited.
Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Sue M Liu, Andrew P R Sutherland, +7 authors, Vijay K Kuchroo.
J Immunol, 2011 Nov 30; 188(1). PMID: 22124121    Free PMC article.
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.
Jeffrey Pido-Lopez, William W Kwok, +2 authors, Neil A Williams.
PLoS Pathog, 2011 Dec 07; 7(12). PMID: 22144893    Free PMC article.
Induction of immunological tolerance by oral anti-CD3.
Andre Pires da Cunha, Howard L Weiner.
Clin Dev Immunol, 2011 Dec 14; 2012. PMID: 22162715    Free PMC article.
Review.
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
Pietro Presicce, Kris Orsborn, +3 authors, Claire A Chougnet.
PLoS One, 2011 Dec 14; 6(12). PMID: 22162758    Free PMC article.
Malignant B cells induce the conversion of CD4+CD25- T cells to regulatory T cells in B-cell non-Hodgkin lymphoma.
Yixiang Han, Jianbo Wu, +7 authors, Shenghui Zhang.
PLoS One, 2011 Dec 17; 6(12). PMID: 22174855    Free PMC article.
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Seng-Ryong Woo, Meghan E Turnis, +18 authors, Dario A A Vignali.
Cancer Res, 2011 Dec 22; 72(4). PMID: 22186141    Free PMC article.
Highly Cited.
Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.
Li-Wen Lai, Kim-Chong Yong, Yeong-Hau H Lien.
Kidney Int, 2011 Dec 23; 81(10). PMID: 22189844    Free PMC article.
Cancer immunotherapy comes of age.
Ira Mellman, George Coukos, Glenn Dranoff.
Nature, 2011 Dec 24; 480(7378). PMID: 22193102    Free PMC article.
Highly Cited. Review.
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
Yuming Yu, Jennifer R Zitzner, +6 authors, Xunrong Luo.
PLoS One, 2011 Dec 24; 6(12). PMID: 22194954    Free PMC article.
The battle against immunopathology: infectious tolerance mediated by regulatory T cells.
David M Gravano, Dario A A Vignali.
Cell Mol Life Sci, 2011 Dec 30; 69(12). PMID: 22205213    Free PMC article.
Review.
Foxp3(+) regulatory T cells, immune stimulation and host defence against infection.
Jared H Rowe, James M Ertelt, Sing Sing Way.
Immunology, 2012 Jan 04; 136(1). PMID: 22211994    Free PMC article.
Review.
Monogenic autoimmunity.
Mickie H Cheng, Mark S Anderson.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224765    Free PMC article.
Review.
Regulatory T cells: mechanisms of differentiation and function.
Steven Z Josefowicz, Li-Fan Lu, Alexander Y Rudensky.
Annu Rev Immunol, 2012 Jan 10; 30. PMID: 22224781    Free PMC article.
Highly Cited. Review.
Re-establishing immunological self-tolerance in autoimmune disease.
Shimon Sakaguchi, Fiona Powrie, Richard M Ransohoff.
Nat Med, 2012 Jan 10; 18(1). PMID: 22227673
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Curr Opin Immunol, 2012 Jan 13; 24(2). PMID: 22236695    Free PMC article.
Highly Cited. Review.
Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function.
Yujie Liu, Liqing Wang, +2 authors, Wayne W Hancock.
PLoS One, 2012 Jan 17; 7(1). PMID: 22247766    Free PMC article.
Association of CTLA-4 gene polymorphisms with sporadic breast cancer risk and clinical features in Han women of northeast China.
Dalin Li, Qiujin Zhang, +4 authors, Da Pang.
Mol Cell Biochem, 2012 Jan 18; 364(1-2). PMID: 22249287
Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome.
F Barzaghi, L Passerini, +17 authors, R Bacchetta.
J Autoimmun, 2012 Jan 24; 38(1). PMID: 22264504    Free PMC article.
Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation.
Ani Grigorian, Haik Mkhikian, Michael Demetriou.
Ann N Y Acad Sci, 2012 Feb 01; 1253. PMID: 22288682    Free PMC article.
Review.
Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions.
Stephen C Juvet, Li Zhang.
J Mol Cell Biol, 2012 Feb 02; 4(1). PMID: 22294241    Free PMC article.
Review.
Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
K Singh, N Kozyr, +4 authors, L S Kean.
Am J Transplant, 2012 Feb 04; 12(6). PMID: 22300641    Free PMC article.
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Peng Gu, Julia Fang Gao, +3 authors, Li Zhang.
Cell Mol Immunol, 2012 Feb 07; 9(2). PMID: 22307040    Free PMC article.
Accumulation of CCR4⁺CTLA-4 FOXP3⁺CD25(hi) regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells.
Helena Svensson, Veronica Olofsson, +5 authors, Marianne Quiding-Järbrink.
PLoS One, 2012 Feb 10; 7(2). PMID: 22319577    Free PMC article.
Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris.
Jaclyn Peraino, Huiping Zhang, +4 authors, Zhirui Wang.
Protein Expr Purif, 2012 Feb 14; 82(2). PMID: 22326797    Free PMC article.
Targeting regulatory T cells.
Christine Ménétrier-Caux, Tyler Curiel, +3 authors, Weiping Zou.
Target Oncol, 2012 Feb 14; 7(1). PMID: 22327882
Review.
Immunotherapy earns its spot in the ranks of cancer therapy.
Drew Pardoll, Charles Drake.
J Exp Med, 2012 Feb 15; 209(2). PMID: 22330682    Free PMC article.
Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells.
Jozsef Karman, Ji-Lei Jiang, +7 authors, Yunxiang Zhu.
J Biol Chem, 2012 Feb 18; 287(14). PMID: 22337882    Free PMC article.
The role of interleukin-2 during homeostasis and activation of the immune system.
Onur Boyman, Jonathan Sprent.
Nat Rev Immunol, 2012 Feb 22; 12(3). PMID: 22343569
Highly Cited. Review.
A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand.
Avijit Ray, Sreemanti Basu, +2 authors, Bonnie N Dittel.
J Immunol, 2012 Mar 01; 188(7). PMID: 22368274    Free PMC article.
Highly Cited.
CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.
Tomoyuki Shimazu, Ryuji Iida, +4 authors, Paul W Kincade.
Blood, 2012 Mar 01; 119(21). PMID: 22371880    Free PMC article.
The immunogenetic architecture of autoimmune disease.
An Goris, Adrian Liston.
Cold Spring Harb Perspect Biol, 2012 Mar 03; 4(3). PMID: 22383754    Free PMC article.
Review.
Breakdown in peripheral tolerance in type 1 diabetes in mice and humans.
Lukas T Jeker, Hélène Bour-Jordan, Jeffrey A Bluestone.
Cold Spring Harb Perspect Med, 2012 Mar 07; 2(3). PMID: 22393537    Free PMC article.
Review.
Historical overview of immunological tolerance.
Ronald H Schwartz.
Cold Spring Harb Perspect Biol, 2012 Mar 08; 4(4). PMID: 22395097    Free PMC article.
Review.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Xuguang Tai, François Van Laethem, +9 authors, Alfred Singer.
Blood, 2012 Mar 10; 119(22). PMID: 22403258    Free PMC article.
Highly Cited.
Shedding light on melanocyte pathobiology in vivo.
M Raza Zaidi, Edward C De Fabo, Frances P Noonan, Glenn Merlino.
Cancer Res, 2012 Mar 17; 72(7). PMID: 22422936    Free PMC article.
Review.
Regulation generation: the suppressive functions of human regulatory T cells.
Wendy A Goodman, Kevin D Cooper, Thomas S McCormick.
Crit Rev Immunol, 2012 Mar 21; 32(1). PMID: 22428855    Free PMC article.
Review.
The blockade of immune checkpoints in cancer immunotherapy.
Drew M Pardoll.
Nat Rev Cancer, 2012 Mar 23; 12(4). PMID: 22437870    Free PMC article.
Highly Cited. Review.
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.
Thomas Duhen, Rebekka Duhen, +2 authors, Daniel J Campbell.
Blood, 2012 Mar 23; 119(19). PMID: 22438251    Free PMC article.
Highly Cited.
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Soyoung Oh, Malinda Aitken, +4 authors, Andrew J Caton.
J Immunol, 2012 Mar 28; 188(9). PMID: 22450809    Free PMC article.
Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.
Janet Y Li, Steven Horwitz, +3 authors, Christiane Querfeld.
Cancer Manag Res, 2012 Mar 30; 4. PMID: 22457602    Free PMC article.
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
Anthony Joetham, Hiroshi Ohnishi, +5 authors, Erwin W Gelfand.
J Biol Chem, 2012 Mar 31; 287(21). PMID: 22461627    Free PMC article.
MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.
Magali Noval Rivas, Yi T Koh, +4 authors, Talal A Chatila.
J Clin Invest, 2012 Apr 03; 122(5). PMID: 22466646    Free PMC article.
Regulation of Immune Responses by Spontaneous and T cell-mediated Dendritic Cell Death.
Min Chen, Jin Wang.
J Clin Cell Immunol, 2012 Apr 03; S3. PMID: 22468233    Free PMC article.
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.
Ping Yu, Jason C Steel, +5 authors, Thomas A Waldmann.
Proc Natl Acad Sci U S A, 2012 Apr 05; 109(16). PMID: 22474386    Free PMC article.
Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice.
Shee Eun Lee, Xiangli Li, +6 authors, Eyal Raz.
Gastroenterology, 2012 Apr 06; 143(1). PMID: 22475534    Free PMC article.
Multiple associations between a broad spectrum of autoimmune diseases, chronic inflammatory diseases and cancer.
Alexis L Franks, Jill E Slansky.
Anticancer Res, 2012 Apr 12; 32(4). PMID: 22493341    Free PMC article.
Review.
Targeting costimulatory molecules to improve antitumor immunity.
Daria Capece, Daniela Verzella, +2 authors, Edoardo Alesse.
J Biomed Biotechnol, 2012 Apr 14; 2012. PMID: 22500111    Free PMC article.
Review.
Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer.
Akira Yoneda, Shinichiro Ito, +6 authors, Yasuhiro Nagata.
World J Gastroenterol, 2012 Apr 18; 18(13). PMID: 22509078    Free PMC article.
Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.
Melanie P Matheu, Yan Su, +4 authors, Michael D Cahalan.
Proc Natl Acad Sci U S A, 2012 Apr 19; 109(20). PMID: 22511718    Free PMC article.
T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice.
Daniel R Neill, Vitor E Fernandes, +8 authors, Peter W Andrew.
PLoS Pathog, 2012 May 09; 8(4). PMID: 22563306    Free PMC article.
Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells.
Katrien Pletinckx, Anja Döhler, Vladimir Pavlovic, Manfred B Lutz.
Front Immunol, 2011 Jan 01; 2. PMID: 22566829    Free PMC article.
The molecular mechanisms of regulatory T cell immunosuppression.
Pushpa Pandiyan, Lixin Zheng, Michael J Lenardo.
Front Immunol, 2011 Jan 01; 2. PMID: 22566849    Free PMC article.
Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
Peter J L Lane, Fabrina M Gaspal, +2 authors, Graham Anderson.
Front Immunol, 2012 May 09; 3. PMID: 22566908    Free PMC article.
The role of coinhibitory signaling pathways in transplantation and tolerance.
Martina M McGrath, Nader Najafian.
Front Immunol, 2012 May 09; 3. PMID: 22566929    Free PMC article.
Molecular mechanisms of treg-mediated T cell suppression.
Angelika Schmidt, Nina Oberle, Peter H Krammer.
Front Immunol, 2012 May 09; 3. PMID: 22566933    Free PMC article.
Highly Cited.
Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities.
Florencia Paula Madorsky-Rowdo, María Laura Lacreu, José Mordoh.
Front Immunol, 2012 May 09; 3. PMID: 22566975    Free PMC article.
Regulatory immune cells in transplantation.
Kathryn J Wood, Andrew Bushell, Joanna Hester.
Nat Rev Immunol, 2012 May 26; 12(6). PMID: 22627860
Highly Cited. Review.
Depletion of Tregs for adoptive T-cell therapy using CD44 and CD137 as selection markers.
Brian G Till, Oliver W Press.
Immunotherapy, 2012 May 31; 4(5). PMID: 22642331    Free PMC article.
HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals.
Yorifumi Satou, Atae Utsunomiya, +3 authors, Masao Matsuoka.
Retrovirology, 2012 Jun 01; 9. PMID: 22647666    Free PMC article.
Immunogenetic mechanisms leading to thyroid autoimmunity: recent advances in identifying susceptibility genes and regions.
Oliver J Brand, Stephen C L Gough.
Curr Genomics, 2012 Jun 02; 12(8). PMID: 22654554    Free PMC article.
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model.
Afonso R M Almeida, Inês F Amado, +4 authors, Antonio A Freitas.
Front Immunol, 2012 Jun 02; 3. PMID: 22654881    Free PMC article.
Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells.
N M Lerret, J L Houlihan, +3 authors, X Luo.
Am J Transplant, 2012 Jun 12; 12(9). PMID: 22681667    Free PMC article.
Plasmodium inui infection reduces the efficacy of a simian immunodeficiency virus DNA vaccine in a rhesus macaque model through alteration of the vaccine-induced immune response.
Jiangmei Yin, Maryanne T Vahey, +10 authors, Jean D Boyer.
J Infect Dis, 2012 Jun 14; 206(4). PMID: 22693228    Free PMC article.
Boosting regulatory T cell function by CD4 stimulation enters the clinic.
Christian Becker, Tobias Bopp, Helmut Jonuleit.
Front Immunol, 2012 Jun 22; 3. PMID: 22719741    Free PMC article.
CD28 family and chronic rejection: "to belatacept...And beyond!".
Marcos V Silva, Juliana R Machado, +3 authors, Rosana R M Corrêa.
J Transplant, 2012 Jun 22; 2012. PMID: 22720132    Free PMC article.
Human regulatory T cells induce T-lymphocyte senescence.
Jian Ye, Xingxu Huang, +6 authors, Guangyong Peng.
Blood, 2012 Jun 23; 120(10). PMID: 22723548    Free PMC article.
Immune checkpoints in central nervous system autoimmunity.
Nicole Joller, Anneli Peters, Ana C Anderson, Vijay K Kuchroo.
Immunol Rev, 2012 Jun 26; 248(1). PMID: 22725958    Free PMC article.
Review.
Genetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies.
Haowen Xiao, Yi Luo, +14 authors, He Huang.
Haematologica, 2012 Jun 27; 97(12). PMID: 22733023    Free PMC article.
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance.
Mara Kornete, Ciriaco A Piccirillo.
Front Immunol, 2012 Jun 28; 3. PMID: 22737152    Free PMC article.
Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer.
Helene Pere, Corinne Tanchot, +17 authors, Eric Tartour.
Oncoimmunology, 2012 Jun 28; 1(3). PMID: 22737608    Free PMC article.
Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Chun Jing Wang, Rupert Kenefeck, +6 authors, Lucy S K Walker.
J Immunol, 2012 Jul 04; 189(3). PMID: 22753931    Free PMC article.
Multiple treg suppressive modules and their adaptability.
James B Wing, Shimon Sakaguchi.
Front Immunol, 2012 Jul 04; 3. PMID: 22754556    Free PMC article.
The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.
C N Magee, O Boenisch, N Najafian.
Am J Transplant, 2012 Jul 05; 12(10). PMID: 22759274    Free PMC article.
Review.
Spontaneous autoimmunity in the absence of IL-2 is driven by uncontrolled dendritic cells.
Sara H Isakson, Shoshana D Katzman, Katrina K Hoyer.
J Immunol, 2012 Jul 11; 189(4). PMID: 22778392    Free PMC article.
Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.
Christian T Mayer, Luciana Berod, Tim Sparwasser.
Front Immunol, 2012 Jul 12; 3. PMID: 22783257    Free PMC article.
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.
Akio Ohta, Radhika Kini, +3 authors, Michail Sitkovsky.
Front Immunol, 2012 Jul 12; 3. PMID: 22783261    Free PMC article.
Highly Cited.
Foxp3+ Regulatory T-cells and IL-2: The Moirai of T-cell Fates?
Georg Gasteiger, Wolfgang Kastenmuller.
Front Immunol, 2012 Jul 19; 3. PMID: 22807926    Free PMC article.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
Hortensia de la Fuente, Danay Cibrián, Francisco Sánchez-Madrid.
FEBS Lett, 2012 Jul 24; 586(18). PMID: 22819828    Free PMC article.
Review.
Autologous regulatory T cells for the treatment of type 1 diabetes.
James A Thompson, Daniel Perry, Todd M Brusko.
Curr Diab Rep, 2012 Jul 31; 12(5). PMID: 22843491
Review.
CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.
M J Barnes, T Griseri, +3 authors, A Izcue.
Mucosal Immunol, 2012 Aug 23; 6(2). PMID: 22910217    Free PMC article.
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Dalya R Soond, Elizabeth C M Slack, +2 authors, Klaus Okkenhaug.
Front Immunol, 2012 Aug 23; 3. PMID: 22912633    Free PMC article.
In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells.
Pietro Presicce, Maria E Moreno-Fernandez, +2 authors, Claire A Chougnet.
PLoS One, 2012 Aug 23; 7(8). PMID: 22912740    Free PMC article.
FOXO transcription factors throughout T cell biology.
Stephen M Hedrick, Rodrigo Hess Michelini, +2 authors, Erica L Stone.
Nat Rev Immunol, 2012 Aug 25; 12(9). PMID: 22918467    Free PMC article.
Highly Cited. Review.
Translating tolerogenic therapies to the clinic - where do we stand?
Fadi Issa, Kathryn J Wood.
Front Immunol, 2012 Aug 31; 3. PMID: 22934094    Free PMC article.
MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
Therese Liechtenstein, Ines Dufait, +2 authors, David Escors.
Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252    Free PMC article.
Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.
Maria Grazia Ruocco, Karsten A Pilones, +7 authors, Sandra Demaria.
J Clin Invest, 2012 Sep 05; 122(10). PMID: 22945631    Free PMC article.
Highly Cited.
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Martin Vaeth, Ulrike Schliesser, +9 authors, Friederike Berberich-Siebelt.
Proc Natl Acad Sci U S A, 2012 Sep 20; 109(40). PMID: 22991461    Free PMC article.
Transient deficiency of dendritic cells results in lack of a merozoite surface protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection.
Anne-Marit Sponaas, Nikolai Belyaev, +2 authors, Jean Langhorne.
Infect Immun, 2012 Sep 26; 80(12). PMID: 23006847    Free PMC article.
T-cell inhibitors: a bench-to-bedside review.
Shinjita Das, Kiyoshi Ariizumi, Ponciano D Cruz.
Dermatitis, 2012 Sep 27; 23(5). PMID: 23010825    Free PMC article.
Review.
Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes.
D Han, X Cai, +4 authors, Z Chen.
Clin Exp Immunol, 2012 Oct 09; 170(2). PMID: 23039883    Free PMC article.
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.
Wiebke Hansen, Marina Hutzler, +10 authors, Iris Helfrich.
J Exp Med, 2012 Oct 10; 209(11). PMID: 23045606    Free PMC article.
Highly Cited.
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.
Yuning Lu, Helga Schneider, Christopher E Rudd.
Blood, 2012 Oct 11; 120(23). PMID: 23047820    Free PMC article.
Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.
Karthick Raja Muthu Raja, Lucie Rihova, +3 authors, Roman Hajek.
PLoS One, 2012 Oct 17; 7(10). PMID: 23071717    Free PMC article.
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells.
Andrea Balogh, Eszter Persa, +4 authors, Katalin Lumniczky.
Inflamm Res, 2012 Oct 20; 62(2). PMID: 23080082
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.
Louisa E Jeffery, Alice M Wood, +6 authors, David M Sansom.
J Immunol, 2012 Oct 23; 189(11). PMID: 23087405    Free PMC article.
Highly Cited.
The confluence of radiotherapy and immunotherapy.
Byron Burnette, Yang-Xin Fu, Ralph R Weichselbaum.
Front Oncol, 2012 Oct 23; 2. PMID: 23087904    Free PMC article.
Strategies for enhancing vaccine-induced CTL antitumor immune responses.
Xin Yong, Yü-Feng Xiao, +5 authors, Shi-Ming Yang.
J Biomed Biotechnol, 2012 Oct 25; 2012. PMID: 23093850    Free PMC article.
Review.
Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance.
C Tanchot, M Terme, +7 authors, E Tartour.
Cancer Microenviron, 2012 Oct 30; 6(2). PMID: 23104434    Free PMC article.
From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.
Dongmei Han, Xiaodong Cai, +2 authors, Zhibin Chen.
Front Immunol, 2012 Nov 01; 3. PMID: 23112798    Free PMC article.
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
Erica G Schmitt, Dipica Haribhai, +14 authors, Calvin B Williams.
J Immunol, 2012 Nov 06; 189(12). PMID: 23125413    Free PMC article.
Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
Weiming Ouyang, Will Liao, +13 authors, Ming O Li.
Nature, 2012 Nov 09; 491(7425). PMID: 23135404    Free PMC article.
Highly Cited.
Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways.
Seon-Yeong Lee, Mi-La Cho, +10 authors, Ho-Youn Kim.
Immunology, 2012 Nov 22; 137(4). PMID: 23167249    Free PMC article.
Immunotherapies: the blockade of inhibitory signals.
Yan-Ling Wu, Jing Liang, +2 authors, Hiroshi Sugiyama.
Int J Biol Sci, 2012 Dec 01; 8(10). PMID: 23197939    Free PMC article.
Review.
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
Anna Majowicz, Sander van der Marel, +4 authors, Valerie Ferreira.
BMC Gastroenterol, 2012 Dec 04; 12. PMID: 23198878    Free PMC article.
Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.
Kunihiro Ichinose, Zheng Zhang, +6 authors, George C Tsokos.
Arthritis Rheum, 2012 Dec 04; 65(3). PMID: 23203389    Free PMC article.
Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis.
Maíra Felonato, Adriana Pina, +4 authors, Vera L G Calich.
PLoS One, 2012 Dec 12; 7(11). PMID: 23226464    Free PMC article.
Regulatory T cells in HIV infection: can immunotherapy regulate the regulator?
Mohammad-Ali Jenabian, Petronela Ancuta, Norbert Gilmore, Jean-Pierre Routy.
Clin Dev Immunol, 2012 Dec 20; 2012. PMID: 23251223    Free PMC article.
Review.
Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice.
Takuji Ishimoto, Michiko Shimada, +8 authors, Richard J Johnson.
Nephrol Dial Transplant, 2012 Dec 25; 28(6). PMID: 23262434    Free PMC article.
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Johan Verhagen, Raphaël Genolet, +5 authors, David C Wraith.
Proc Natl Acad Sci U S A, 2012 Dec 26; 110(3). PMID: 23267099    Free PMC article.
An obligate cell-intrinsic function for CD28 in Tregs.
Ruan Zhang, Alexandria Huynh, +3 authors, Laurence A Turka.
J Clin Invest, 2013 Jan 03; 123(2). PMID: 23281398    Free PMC article.
Highly Cited.
Adaptive immunity in atherogenesis: new insights and therapeutic approaches.
Andrew H Lichtman, Christoph J Binder, Sotirios Tsimikas, Joseph L Witztum.
J Clin Invest, 2013 Jan 03; 123(1). PMID: 23281407    Free PMC article.
Highly Cited. Review.
The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.
Melanie Stumpf, Xuyu Zhou, Jeffrey A Bluestone.
J Immunol, 2013 Jan 08; 190(3). PMID: 23293354    Free PMC article.
Polymorphisms in CTLA4 influence incidence of drug-induced liver injury after renal transplantation in Chinese recipients.
Yifeng Guo, Yu Fan, +3 authors, Fang Guo.
PLoS One, 2013 Jan 10; 7(12). PMID: 23300559    Free PMC article.
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.
Ngar-Yee Huen, Alan Lap-Yin Pang, +11 authors, Kwong Y Tsang.
Int J Cancer, 2013 Jan 16; 133(2). PMID: 23319273    Free PMC article.
Targeting the B7 family of co-stimulatory molecules: successes and challenges.
Joseph R Podojil, Stephen D Miller.
BioDrugs, 2013 Jan 19; 27(1). PMID: 23329394    Free PMC article.
Review.
Modulation of p38 MAPK signaling enhances dendritic cell activation of human CD4+ Th17 responses to ovarian tumor antigen.
Martin J Cannon, Hannah E Goyne, +4 authors, Maurizio Chiriva-Internati.
Cancer Immunol Immunother, 2013 Jan 29; 62(5). PMID: 23354626    Free PMC article.
Primary mucosal melanoma arising from the eustachian tube with CTLA-4, IL-17A, IL-17C, and IL-17E upregulation.
Calvin Wei, Sasis Sirikanjanapong, +4 authors, Beverly Y Wang.
Ear Nose Throat J, 2013 Jan 29; 92(1). PMID: 23354891    Free PMC article.
Down-regulation of CTLA-4 by HIV-1 Nef protein.
Mohamed El-Far, Catherine Isabelle, +12 authors, Rafick-Pierre Sékaly.
PLoS One, 2013 Feb 02; 8(1). PMID: 23372701    Free PMC article.
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells.
Wing-hong Kwan, William van der Touw, +2 authors, Peter S Heeger.
J Exp Med, 2013 Feb 06; 210(2). PMID: 23382542    Free PMC article.
Highly Cited.
CTLA-4 blockade in tumor models: an overview of preclinical and translational research.
Joseph F Grosso, Maria N Jure-Kunkel.
Cancer Immun, 2013 Feb 08; 13. PMID: 23390376    Free PMC article.
Highly Cited. Review.
Tailoring gut immune responses with lipoteichoic acid-deficient Lactobacillus acidophilus.
Yaíma L Lightfoot, Mansour Mohamadzadeh.
Front Immunol, 2013 Feb 08; 4. PMID: 23390423    Free PMC article.
NF-κB: roles and regulation in different CD4(+) T-cell subsets.
Hyunju Oh, Sankar Ghosh.
Immunol Rev, 2013 Feb 15; 252(1). PMID: 23405894    Free PMC article.
Highly Cited. Review.
Impact of microbes on autoimmune diseases.
Claudia Danzer, Jochen Mattner.
Arch Immunol Ther Exp (Warsz), 2013 Feb 19; 61(3). PMID: 23417246    Free PMC article.
Review.
Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes.
Changyun Hu, Heyuan Ding, +2 authors, Li Wen.
Diabetes, 2013 Mar 01; 62(8). PMID: 23447122    Free PMC article.
Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy.
H Maazi, S Shirinbak, +4 authors, A J M van Oosterhout.
Clin Exp Immunol, 2013 Mar 14; 172(1). PMID: 23480191    Free PMC article.
Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.
Michael Weber, Corinna Lupp, +6 authors, Markus P Radsak.
PLoS One, 2013 Mar 14; 8(3). PMID: 23483980    Free PMC article.
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.
S A Quezada, K S Peggs.
Br J Cancer, 2013 Mar 21; 108(8). PMID: 23511566    Free PMC article.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman.
Retrovirology, 2013 Mar 22; 10. PMID: 23514593    Free PMC article.
Review.
Information-theoretic analysis of the dynamics of an executable biological model.
Avital Sadot, Septimia Sarbu, +4 authors, Ilya Shmulevich.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527156    Free PMC article.
Ribavirin Does Not Impair the Suppressive Activity of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells.
Jeewon Lee, Yoon Seok Choi, Eui-Cheol Shin.
Immune Netw, 2013 Apr 06; 13(1). PMID: 23559897    Free PMC article.
Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA.
A U Engela, M J Hoogduijn, +4 authors, C C Baan.
Clin Exp Immunol, 2013 Apr 24; 173(2). PMID: 23607314    Free PMC article.
CD4⁺ CD45RA⁻ FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes.
F Haseda, A Imagawa, +2 authors, T Hanafusa.
Clin Exp Immunol, 2013 Apr 24; 173(2). PMID: 23607886    Free PMC article.
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy.
Andrew M Intlekofer, Craig B Thompson.
J Leukoc Biol, 2013 Apr 30; 94(1). PMID: 23625198    Free PMC article.
Highly Cited. Review.
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.
Jaikumar Duraiswamy, Karen M Kaluza, Gordon J Freeman, George Coukos.
Cancer Res, 2013 May 02; 73(12). PMID: 23633484    Free PMC article.
Highly Cited.
T-cell tolerance in cancer.
Roza Nurieva, Junmei Wang, Anupama Sahoo.
Immunotherapy, 2013 May 04; 5(5). PMID: 23638746    Free PMC article.
Review.
IL-2-dependent adaptive control of NK cell homeostasis.
Georg Gasteiger, Saskia Hemmers, +2 authors, Alexander Y Rudensky.
J Exp Med, 2013 May 08; 210(6). PMID: 23650439    Free PMC article.
Highly Cited.
Induced and natural regulatory T cells in the development of inflammatory bowel disease.
Christopher G Mayne, Calvin B Williams.
Inflamm Bowel Dis, 2013 May 10; 19(8). PMID: 23656897    Free PMC article.
Review.
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.
Tomoyuki Yamaguchi, Ayumi Kishi, +5 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2013 May 22; 110(23). PMID: 23690575    Free PMC article.
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.
Aurélien Marabelle, Holbrook Kohrt, +13 authors, Ronald Levy.
J Clin Invest, 2013 Jun 04; 123(6). PMID: 23728179    Free PMC article.
Highly Cited.
Induction of immune tolerance and reduction of aggravated lung eosinophilia by co-exposure to Asian sand dust and ovalbumin for 14 weeks in mice.
Miao He, Takamichi Ichinose, +4 authors, Takayuki Shibamoto.
Allergy Asthma Clin Immunol, 2013 Jun 05; 9(1). PMID: 23731974    Free PMC article.
B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells.
James M Ertelt, Esra Z Buyukbasaran, +3 authors, Sing Sing Way.
J Leukoc Biol, 2013 Jun 08; 94(2). PMID: 23744647    Free PMC article.
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction.
Xinjuan Liu, Na Gao, +7 authors, Xiaofeng Zeng.
PLoS One, 2013 Jun 19; 8(6). PMID: 23776439    Free PMC article.
The availability of a functional tumor targeting T-cell repertoire determines the anti-tumor efficiency of combination therapy with anti-CTLA-4 and anti-4-1BB antibodies.
Benjamin A H Jensen, Sara R Pedersen, Jan P Christensen, Allan R Thomsen.
PLoS One, 2013 Jun 21; 8(6). PMID: 23785471    Free PMC article.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
Shahin Shafiani, Crystal Dinh, +7 authors, Kevin B Urdahl.
Immunity, 2013 Jun 25; 38(6). PMID: 23791647    Free PMC article.
Generation and function of induced regulatory T cells.
Erica G Schmitt, Calvin B Williams.
Front Immunol, 2013 Jun 27; 4. PMID: 23801990    Free PMC article.
mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.
Hu Zeng, Kai Yang, +3 authors, Hongbo Chi.
Nature, 2013 Jul 03; 499(7459). PMID: 23812589    Free PMC article.
Highly Cited.
Thymic versus induced regulatory T cells - who regulates the regulators?
Giovanni Antonio Maria Povoleri, Cristiano Scottà, +3 authors, Behdad Afzali.
Front Immunol, 2013 Jul 03; 4. PMID: 23818888    Free PMC article.
miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation.
Samir Kelada, Praveen Sethupathy, +12 authors, Mark S Wilson.
PLoS Pathog, 2013 Jul 05; 9(6). PMID: 23825948    Free PMC article.
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.
Koji Atarashi, Takeshi Tanoue, +19 authors, Kenya Honda.
Nature, 2013 Jul 12; 500(7461). PMID: 23842501
Highly Cited.
Regulatory T cells in the immunodiagnosis and outcome of kidney allograft rejection.
O Franzese, A Mascali, +3 authors, N Di Daniele.
Clin Dev Immunol, 2013 Jul 12; 2013. PMID: 23843861    Free PMC article.
Review.
Treg and CTLA-4: two intertwining pathways to immune tolerance.
Lucy S K Walker.
J Autoimmun, 2013 Jul 16; 45. PMID: 23849743    Free PMC article.
Highly Cited. Review.
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Wim Pierson, Bénédicte Cauwe, +17 authors, Adrian Liston.
Nat Immunol, 2013 Jul 16; 14(9). PMID: 23852275    Free PMC article.
Highly Cited.
New insights into the role of the immune microenvironment in breast carcinoma.
Luis de la Cruz-Merino, Antonio Barco-Sánchez, +12 authors, José Ibáñez Martínez.
Clin Dev Immunol, 2013 Jul 19; 2013. PMID: 23861693    Free PMC article.
Review.
Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models.
Maria Jure-Kunkel, Gregg Masters, +4 authors, Rachel Humphrey.
Cancer Immunol Immunother, 2013 Jul 23; 62(9). PMID: 23873089    Free PMC article.
Regulatory T cells and regulation of allergic airway disease.
Helen Martin, Christian Taube.
Am J Clin Exp Immunol, 2012 Jan 01; 1(2). PMID: 23885322    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.
Christine M Deppong, Traci L Bricker, +3 authors, Jonathan M Green.
J Immunol, 2013 Aug 21; 191(6). PMID: 23956428    Free PMC article.
Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity.
Aurélien Marabelle, Holbrook Kohrt, Ronald Levy.
Clin Cancer Res, 2013 Aug 24; 19(19). PMID: 23965900    Free PMC article.
Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment.
Cesar M Rueda, Paula A Velilla, Claire A Chougnet, Maria T Rugeles.
PLoS One, 2013 Aug 24; 8(8). PMID: 23967152    Free PMC article.
Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies.
Jeong M Kim, Avi Ashkenazi.
J Exp Med, 2013 Aug 28; 210(9). PMID: 23980122    Free PMC article.
Review.
Regulatory T cell in stroke: a new paradigm for immune regulation.
Sheng Chen, Haijian Wu, +3 authors, Jiping Tang.
Clin Dev Immunol, 2013 Aug 29; 2013. PMID: 23983771    Free PMC article.
Review.
Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer.
Alessia Burocchi, Mario P Colombo, Silvia Piconese.
Front Immunol, 2013 Aug 30; 4. PMID: 23986759    Free PMC article.
Regulatory T cells and Atherosclerosis.
Jahaira Lopez Pastrana, Xiaojin Sha, +5 authors, Xiao-Feng Yang.
J Clin Exp Cardiolog, 2013 Sep 03; 2012(Suppl 12). PMID: 23997979    Free PMC article.
CTLA4 gene polymorphisms influence the incidence of infection after renal transplantation in Chinese recipients.
Yifeng Guo, Fang Guo, +4 authors, Junwei Gao.
PLoS One, 2013 Sep 10; 8(8). PMID: 24015180    Free PMC article.
Mesenchymal stem cells control alloreactive CD8(+) CD28(-) T cells.
A U Engela, C C Baan, +4 authors, M J Hoogduijn.
Clin Exp Immunol, 2013 Sep 14; 174(3). PMID: 24028656    Free PMC article.
Secreted and transmembrane 1A is a novel co-stimulatory ligand.
Duncan Howie, Hugo Garcia Rueda, Marion H Brown, Herman Waldmann.
PLoS One, 2013 Sep 17; 8(9). PMID: 24039998    Free PMC article.
Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation.
Dominik Schneidawind, Antonio Pierini, Robert S Negrin.
Blood, 2013 Sep 27; 122(18). PMID: 24068494    Free PMC article.
Review.
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis.
Su-Jin Moon, Jin-Sil Park, +11 authors, Mi-La Cho.
Exp Mol Med, 2013 Oct 05; 45. PMID: 24091748    Free PMC article.
Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.
Tobias Boettler, Youn Soo Choi, +5 authors, Matthias von Herrath.
J Immunol, 2013 Oct 09; 191(10). PMID: 24101548    Free PMC article.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.
Paula D Bos, George Plitas, +2 authors, Alexander Y Rudensky.
J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486    Free PMC article.
Highly Cited.
Regulatory T cells in AKI.
Gilbert R Kinsey, Rahul Sharma, Mark D Okusa.
J Am Soc Nephrol, 2013 Oct 19; 24(11). PMID: 24136922    Free PMC article.
Review.
Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients.
H-B Jie, N Gildener-Leapman, +4 authors, R L Ferris.
Br J Cancer, 2013 Oct 31; 109(10). PMID: 24169351    Free PMC article.
Highly Cited.
Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.
D V Chan, H M Gibson, +4 authors, H K Wong.
Genes Immun, 2013 Nov 01; 15(1). PMID: 24173147    Free PMC article.
Induction and stability of the anergic phenotype in T cells.
Rut Valdor, Fernando Macian.
Semin Immunol, 2013 Nov 12; 25(4). PMID: 24211041    Free PMC article.
Review.
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Gouri Chattopadhyay, Ethan M Shevach.
J Immunol, 2013 Nov 13; 191(12). PMID: 24218453    Free PMC article.
Expanding role of T cells in acute kidney injury.
Gilbert R Kinsey, Mark D Okusa.
Curr Opin Nephrol Hypertens, 2013 Nov 16; 23(1). PMID: 24231312    Free PMC article.
Review.
IL-2 coordinates IL-2-producing and regulatory T cell interplay.
Inês F Amado, Julien Berges, +6 authors, Antonio A Freitas.
J Exp Med, 2013 Nov 20; 210(12). PMID: 24249704    Free PMC article.
Progressive Increase of Regulatory T Cells and Decrease of CD8+ T Cells and CD8+ T Cells/Regulatory T Cells Ratio during Colorectal Cancer Development.
Tae Jung Jang.
Korean J Pathol, 2013 Nov 21; 47(5). PMID: 24255632    Free PMC article.
CD28 and ITK signals regulate autoreactive T cell trafficking.
Nitya Jain, Bing Miu, +8 authors, Joonsoo Kang.
Nat Med, 2013 Nov 26; 19(12). PMID: 24270545    Free PMC article.
ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner.
Jian Zheng, Ping-Lung Chan, +6 authors, Wenwei Tu.
PLoS One, 2013 Dec 07; 8(12). PMID: 24312642    Free PMC article.
FoxP3⁺ regulatory T cells attenuate experimental necrotizing enterocolitis.
Bridgette M Dingle, Yuying Liu, +3 authors, Dat Q Tran.
PLoS One, 2013 Dec 25; 8(12). PMID: 24367573    Free PMC article.
Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells.
Nahzli Dilek, Nicolas Poirier, +7 authors, Bernard Vanhove.
PLoS One, 2014 Jan 01; 8(12). PMID: 24376655    Free PMC article.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Jagadeesh Bayry.
Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307    Free PMC article.
Review.
Regulatory T cell ablation causes acute T cell lymphopenia.
Bruno Moltedo, Saskia Hemmers, Alexander Y Rudensky.
PLoS One, 2014 Jan 28; 9(1). PMID: 24466225    Free PMC article.
Immunotherapy for prostate cancer: recent developments and future challenges.
Michael T Schweizer, Charles G Drake.
Cancer Metastasis Rev, 2014 Jan 31; 33(2-3). PMID: 24477411    Free PMC article.
Review.
Combining low-dose or metronomic chemotherapy with anticancer vaccines: A therapeutic opportunity for lymphomas.
Heng Sheng Sow, Stephen R Mattarollo.
Oncoimmunology, 2014 Feb 06; 2(12). PMID: 24498564    Free PMC article.
Review.
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Peter S Kim, Caroline Jochems, +5 authors, Benedetto Farsaci.
J Immunol, 2014 Feb 12; 192(6). PMID: 24516200    Free PMC article.
Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
Bodo C Melnik, Swen Malte John, Gerd Schmitz.
J Transl Med, 2014 Feb 14; 12. PMID: 24521175    Free PMC article.
Review.
High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
A Strömbeck, H Rabe, +6 authors, A Rudin.
Clin Exp Allergy, 2014 Feb 18; 44(7). PMID: 24528482    Free PMC article.
Impairment of T cell function in parasitic infections.
Vasco Rodrigues, Anabela Cordeiro-da-Silva, +4 authors, Jérôme Estaquier.
PLoS Negl Trop Dis, 2014 Feb 20; 8(2). PMID: 24551250    Free PMC article.
Review.
Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance.
Jason Miska, Midhat H Abdulreda, +5 authors, Zhibin Chen.
J Exp Med, 2014 Feb 26; 211(3). PMID: 24567447    Free PMC article.
Regulatory T cells as immunotherapy.
Benjamin D Singer, Landon S King, Franco R D'Alessio.
Front Immunol, 2014 Feb 28; 5. PMID: 24575095    Free PMC article.
Highly Cited. Review.
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
Martin Vaeth, Gerd Müller, +6 authors, Friederike Berberich-Siebelt.
J Exp Med, 2014 Mar 05; 211(3). PMID: 24590764    Free PMC article.
Highly Cited.
Expression of CTLA-4 and Foxp3 in peripheral blood T cells of patients with squamous cell laryngeal carcinoma.
Katarzyna Starska, Ewa Forma, +6 authors, Magdalena Bryś.
Contemp Oncol (Pozn), 2013 Jan 01; 17(4). PMID: 24592125    Free PMC article.
Animal models of autoimmune neuropathy.
Betty Soliven.
ILAR J, 2014 Mar 13; 54(3). PMID: 24615441    Free PMC article.
Review.
Host immune response to infection and cancer: unexpected commonalities.
Romina S Goldszmid, Amiran Dzutsev, Giorgio Trinchieri.
Cell Host Microbe, 2014 Mar 19; 15(3). PMID: 24629336    Free PMC article.
Review.
Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.
Melanie Stumpf, Xuyu Zhou, Shunsuke Chikuma, Jeffrey A Bluestone.
Eur J Immunol, 2014 Mar 22; 44(6). PMID: 24648182    Free PMC article.
Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C.
Matthew Witek, Erik S Blomain, +3 authors, Adam E Snook.
Int J Radiat Oncol Biol Phys, 2014 Mar 26; 88(5). PMID: 24661671    Free PMC article.
Human hepatocellular carcinoma-infiltrating CD4⁺CD69⁺Foxp3⁻ regulatory T cell suppresses T cell response via membrane-bound TGF-β1.
Yanmei Han, Yuan Yang, +8 authors, Xuetao Cao.
J Mol Med (Berl), 2014 Mar 29; 92(5). PMID: 24668348
The targeting of immunosuppressive mechanisms in hematological malignancies.
M H Andersen.
Leukemia, 2014 Apr 03; 28(9). PMID: 24691076
Review.
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.
Kok-Fai Kong, Guo Fu, +10 authors, Amnon Altman.
Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705298    Free PMC article.
Highly Cited.
Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis.
Hardis Rabe, Inger Nordström, +2 authors, Anna Rudin.
Immunology, 2014 Apr 09; 141(3). PMID: 24708420    Free PMC article.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.
Kesley Attridge, Lucy S K Walker.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457    Free PMC article.
Review.
tTregs, pTregs, and iTregs: similarities and differences.
Ethan M Shevach, Angela M Thornton.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712461    Free PMC article.
Highly Cited. Review.
The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.
Xiaomei Yuan, Guoyan Cheng, Thomas R Malek.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712462    Free PMC article.
Review.
Regulatory T cells in autoimmune neuroinflammation.
Markus Kleinewietfeld, David A Hafler.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712469    Free PMC article.
Highly Cited. Review.
A VISTA on PD-1H.
Yang Liu.
J Clin Invest, 2014 Apr 20; 124(5). PMID: 24743142    Free PMC article.
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.
Nicole Joller, Ester Lozano, +13 authors, Vijay K Kuchroo.
Immunity, 2014 Apr 22; 40(4). PMID: 24745333    Free PMC article.
Highly Cited.
Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy.
Thomas E Stinchcombe.
Med Oncol, 2014 Apr 22; 31(5). PMID: 24748366    Free PMC article.
Review.
Molecular mechanisms in autoimmune type 1 diabetes: a critical review.
Zhiguo Xie, Christopher Chang, Zhiguang Zhou.
Clin Rev Allergy Immunol, 2014 Apr 23; 47(2). PMID: 24752371
Review.
Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells.
Florian Wirsdörfer, Federica Cappuccini, +5 authors, Verena Jendrossek.
Radiat Oncol, 2014 Apr 29; 9. PMID: 24766907    Free PMC article.
Regulatory T cells-an important target for cancer immunotherapy.
Jae Il Shin, Sang-Jun Ha.
Nat Rev Clin Oncol, 2014 May 02; 11(6). PMID: 24781417
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
Christian A Bauer, Edward Y Kim, +3 authors, Thorsten R Mempel.
J Clin Invest, 2014 May 09; 124(6). PMID: 24812664    Free PMC article.
Highly Cited.
T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease.
Suresh Gopi Kalathil, Amit Anand Lugade, +4 authors, Yasmin Thanavala.
Am J Respir Crit Care Med, 2014 May 16; 190(1). PMID: 24825462    Free PMC article.
Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.
Tony T Jiang, Vandana Chaturvedi, +5 authors, Sing Sing Way.
J Immunol, 2014 May 20; 192(11). PMID: 24837152    Free PMC article.
Review.
Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.
Anne-Sophie Gautron, Margarita Dominguez-Villar, Marine de Marcken, David A Hafler.
Eur J Immunol, 2014 May 20; 44(9). PMID: 24838857    Free PMC article.
Attenuated Listeria monocytogenes: a powerful and versatile vector for the future of tumor immunotherapy.
Laurence M Wood, Yvonne Paterson.
Front Cell Infect Microbiol, 2014 May 27; 4. PMID: 24860789    Free PMC article.
Review.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.
Andreas Herrmann, Saul J Priceman, +10 authors, Hua Yu.
J Clin Invest, 2014 Jun 04; 124(7). PMID: 24892807    Free PMC article.
VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy.
J Louise Lines, Lorenzo F Sempere, +2 authors, Randolph Noelle.
Cancer Immunol Res, 2014 Jun 05; 2(6). PMID: 24894088    Free PMC article.
Highly Cited.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
Review.
Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand.
Mohan S Maddur, Meenu Sharma, +4 authors, Jagadeesh Bayry.
Nat Commun, 2014 Jun 10; 5. PMID: 24910129    Free PMC article.
Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions.
Tai Hato, Lipika Goyal, +2 authors, Andrew X Zhu.
Hepatology, 2014 Jun 11; 60(5). PMID: 24912948    Free PMC article.
Highly Cited. Review.
Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.
Laura Esposito, Kara M D Hunter, +12 authors, Linda S Wicker.
J Immunol, 2014 Jun 15; 193(2). PMID: 24928993    Free PMC article.
TREG-cell therapies for autoimmune rheumatic diseases.
Makoto Miyara, Yoshinaga Ito, Shimon Sakaguchi.
Nat Rev Rheumatol, 2014 Jul 02; 10(9). PMID: 24980140
Highly Cited. Review.
Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models.
Kouichi Furugaki, Lin Cui, +5 authors, Kenji Nakano.
PLoS One, 2014 Jul 12; 9(7). PMID: 25013909    Free PMC article.
Minimal change disease: a dysregulation of the podocyte CD80-CTLA-4 axis?
Gabriel Cara-Fuentes, Clive H Wasserfall, +2 authors, Eduardo H Garin.
Pediatr Nephrol, 2014 Jul 16; 29(12). PMID: 25017621    Free PMC article.
T-cell co-stimulatory blockade in kidney transplantation: back to the bench.
Leonardo V Riella, Mohamed H Sayegh.
Kidney Int Suppl (2011), 2011 Aug 01; 1(2). PMID: 25018899    Free PMC article.
Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity.
Luciana Berod, Philipp Stüve, +8 authors, Tim Sparwasser.
PLoS One, 2014 Jul 23; 9(7). PMID: 25050936    Free PMC article.
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.
O Palomares, M Martín-Fontecha, +4 authors, C A Akdis.
Genes Immun, 2014 Jul 25; 15(8). PMID: 25056447
Highly Cited. Review.
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.
Daniel S Shin, Ayana Jordan, +5 authors, Fernando Macian.
EMBO Rep, 2014 Jul 31; 15(9). PMID: 25074018    Free PMC article.
Organ-specific and memory treg cells: specificity, development, function, and maintenance.
Iris K Gratz, Daniel J Campbell.
Front Immunol, 2014 Aug 01; 5. PMID: 25076948    Free PMC article.
Review.
Alteration of regulatory T cells in type 1 diabetes mellitus: a comprehensive review.
Tingting Tan, Yufei Xiang, Christopher Chang, Zhiguang Zhou.
Clin Rev Allergy Immunol, 2014 Aug 05; 47(2). PMID: 25086642
Review.
PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation.
Zhiyuan Li, Fang Lin, +10 authors, Bin Li.
J Biol Chem, 2014 Aug 07; 289(39). PMID: 25096571    Free PMC article.
Inducible expression of B7-H1 (PD-L1) and its selective role in tumor site immune modulation.
Miguel F Sanmamed, Lieping Chen.
Cancer J, 2014 Aug 08; 20(4). PMID: 25098285    Free PMC article.
Review.
Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus.
D Mesquita, W M Cruvinel, +3 authors, L E C Andrade.
Braz J Med Biol Res, 2014 Aug 08; 47(8). PMID: 25098715    Free PMC article.
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
Pablo Penaloza-MacMaster, Alice O Kamphorst, +10 authors, Rafi Ahmed.
J Exp Med, 2014 Aug 13; 211(9). PMID: 25113973    Free PMC article.
Highly Cited.
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Xudong Li, Yuqiong Liang, +2 authors, Ye Zheng.
Cell, 2014 Aug 16; 158(4). PMID: 25126782    Free PMC article.
Highly Cited.
A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway.
Ling-Hui Hsu, Kun-Po Li, Kuan-Hua Chu, Bor-Luen Chiang.
Cell Mol Immunol, 2014 Aug 19; 12(3). PMID: 25132452    Free PMC article.
High levels of CD4⁺ CTLA-4⁺ Treg cells and CCR5 density in HIV-1-infected patients with visceral leishmaniasis.
A Vallejo, M Abad-Fernández, +4 authors, J L Casado.
Eur J Clin Microbiol Infect Dis, 2014 Aug 22; 34(2). PMID: 25142804
Utilizing regulatory T cells against rheumatoid arthritis.
Mohammad Haque, Kristin Fino, +2 authors, Jianxun Song.
Front Oncol, 2014 Aug 26; 4. PMID: 25152867    Free PMC article.
Review.
Antibody-based immunotherapy for malignant glioma.
Patrick C Gedeon, Katherine A Riccione, Peter E Fecci, John H Sampson.
Semin Oncol, 2014 Sep 01; 41(4). PMID: 25173142    Free PMC article.
Review.
T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance.
R Abdoli, N Najafian.
Int J Organ Transplant Med, 2014 Sep 04; 5(3). PMID: 25184030    Free PMC article.
Review.
Immunotherapy advances for glioblastoma.
David A Reardon, Gordon Freeman, +7 authors, Glenn Dranoff.
Neuro Oncol, 2014 Sep 06; 16(11). PMID: 25190673    Free PMC article.
Highly Cited. Review.
Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques.
Huma Qureshi, Meritxell Genescà, +3 authors, Christopher J Miller.
PLoS One, 2014 Sep 10; 9(9). PMID: 25203111    Free PMC article.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
Hye Sun Kuehn, Weiming Ouyang, +33 authors, Gulbu Uzel.
Science, 2014 Sep 13; 345(6204). PMID: 25213377    Free PMC article.
Highly Cited.
Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.
Priyadharshini Devarajan, Jason Miska, +2 authors, Zhibin Chen.
J Immunol, 2014 Sep 24; 193(9). PMID: 25246499    Free PMC article.
Continuous requirement for the TCR in regulatory T cell function.
Andrew G Levine, Aaron Arvey, Wei Jin, Alexander Y Rudensky.
Nat Immunol, 2014 Sep 30; 15(11). PMID: 25263123    Free PMC article.
Highly Cited.
From bench to bedside: immunotherapy for prostate cancer.
Brian Wan-Chi Tse, Lidija Jovanovic, +3 authors, Pamela Joan Russell.
Biomed Res Int, 2014 Oct 03; 2014. PMID: 25276838    Free PMC article.
Review.
MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu.
Dewan M S Hossain, Abir K Panda, +7 authors, Gaurisankar Sa.
Immunology, 2014 Oct 07; 144(4). PMID: 25284464    Free PMC article.
Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.
Benjamin D Singer, Jason R Mock, +10 authors, Franco R D'Alessio.
Am J Respir Cell Mol Biol, 2014 Oct 09; 52(5). PMID: 25295995    Free PMC article.
Duality of the immune response in cancer: lessons learned from skin.
Terry R Medler, Lisa M Coussens.
J Invest Dermatol, 2014 Oct 11; 134(e1). PMID: 25302470    Free PMC article.
Review.
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert, Claudia Bode, +37 authors, Bodo Grimbacher.
Nat Med, 2014 Oct 21; 20(12). PMID: 25329329    Free PMC article.
Highly Cited.
CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.
Timothy J Thauland, Yoshinobu Koguchi, Michael L Dustin, David C Parker.
J Immunol, 2014 Oct 31; 193(12). PMID: 25355918    Free PMC article.
Regulatory T cells in B cell follicles.
Jae-Hoon Chang, Yeonseok Chung.
Immune Netw, 2014 Nov 02; 14(5). PMID: 25360073    Free PMC article.
Review.
Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.
S M Krummey, M L Ford.
Am J Transplant, 2014 Nov 13; 14(12). PMID: 25387592    Free PMC article.
Review.
Both PD-1 ligands protect the kidney from ischemia reperfusion injury.
Katarzyna Jaworska, Joanna Ratajczak, +4 authors, Gilbert R Kinsey.
J Immunol, 2014 Nov 19; 194(1). PMID: 25404361    Free PMC article.
Bystander immunotherapy as a strategy to control allergen-driven airway inflammation.
S Navarro, A Lazzari, +4 authors, V Julia.
Mucosal Immunol, 2014 Nov 27; 8(4). PMID: 25425267    Free PMC article.
Immunotherapy in prostate cancer: review of the current evidence.
E M Fernández-García, F E Vera-Badillo, +2 authors, I Duran.
Clin Transl Oncol, 2014 Dec 07; 17(5). PMID: 25480118
Review.
Human mesenchymal stromal cells enhance the immunomodulatory function of CD8(+)CD28(-) regulatory T cells.
Qiuli Liu, Haiqing Zheng, +7 authors, Andy Peng Xiang.
Cell Mol Immunol, 2014 Dec 09; 12(6). PMID: 25482073    Free PMC article.
To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483644    Free PMC article.
Review.
Engineering better immunotherapies via RNA interference.
Mouldy Sioud.
Hum Vaccin Immunother, 2014 Dec 09; 10(11). PMID: 25483669    Free PMC article.
Review.
Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients.
L C M Arruda, J C C Lorenzi, +10 authors, K C R Malmegrim.
Bone Marrow Transplant, 2014 Dec 09; 50(3). PMID: 25486582
Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex®.
Anne-Kristin Heninger, Sabine Wentrup, +5 authors, Jutta Schröder-Braunstein.
Immun Inflamm Dis, 2014 Dec 17; 2(3). PMID: 25505551    Free PMC article.
The delicate balance of melanoma immunotherapy.
David E Gyorki, Margaret Callahan, Jedd D Wolchok, Charlotte E Ariyan.
Clin Transl Immunology, 2013 Aug 01; 2(8). PMID: 25505953    Free PMC article.
Review.
Balance and imbalance in the immune system: life on the edge.
Suzanne L Topalian, Arlene H Sharpe.
Immunity, 2014 Dec 18; 41(5). PMID: 25517610    Free PMC article.
Past, present and future targets for immunotherapy in ovarian cancer.
Carlton L Schwab, Diana P English, +2 authors, Alessandro D Santin.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524384    Free PMC article.
Review.
mTOR signaling, Tregs and immune modulation.
Nicole M Chapman, Hongbo Chi.
Immunotherapy, 2014 Dec 20; 6(12). PMID: 25524385    Free PMC article.
Review.
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.
Peter T Sage, Alison M Paterson, Scott B Lovitch, Arlene H Sharpe.
Immunity, 2014 Dec 20; 41(6). PMID: 25526313    Free PMC article.
Highly Cited.
Diverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.
Helga Schneider, Christopher E Rudd.
Front Immunol, 2014 Dec 30; 5. PMID: 25538704    Free PMC article.
Review.
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Chun Jing Wang, Frank Heuts, +7 authors, Lucy S K Walker.
Proc Natl Acad Sci U S A, 2014 Dec 31; 112(2). PMID: 25548162    Free PMC article.
Highly Cited.
New insights into T-cell cosignaling in allograft rejection and survival.
Scott M Krummey, Mandy L Ford.
Curr Opin Organ Transplant, 2015 Jan 08; 20(1). PMID: 25563991    Free PMC article.
Review.
Confusing signals: recent progress in CTLA-4 biology.
Lucy S K Walker, David M Sansom.
Trends Immunol, 2015 Jan 15; 36(2). PMID: 25582039    Free PMC article.
Highly Cited. Review.
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Dalil Hannani, Marie Vétizou, +30 authors, Laurence Zitvogel.
Cell Res, 2015 Jan 15; 25(2). PMID: 25582080    Free PMC article.
Highly Cited.
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.
Alexander Ulges, Matthias Klein, +27 authors, Tobias Bopp.
Nat Immunol, 2015 Jan 20; 16(3). PMID: 25599562
Highly Cited.
Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression.
Xi Jin, Yanrong Lu, Ye Zhao, Shounan Yi.
Cytotechnology, 2015 Jan 22; 68(4). PMID: 25605448    Free PMC article.
FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer.
Changhua Zhuo, Ye Xu, +5 authors, Bin Li.
Immunol Res, 2015 Jan 23; 61(3). PMID: 25608795
Review.
CD4+ T cell hyporesponsiveness after repeated exposure to Schistosoma mansoni larvae is dependent upon interleukin-10.
Catriona T Prendergast, David E Sanin, Peter C Cook, Adrian P Mountford.
Infect Immun, 2015 Jan 28; 83(4). PMID: 25624353    Free PMC article.
A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.
Tie Zheng Hou, Omar S Qureshi, +4 authors, David M Sansom.
J Immunol, 2015 Jan 30; 194(5). PMID: 25632005    Free PMC article.
Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs.
Xiaowei Yang, Jingjing Zhu, +4 authors, Baohua Zhou.
PLoS One, 2015 Feb 04; 10(2). PMID: 25646897    Free PMC article.
Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.
Melanie P Matheu, Shivashankar Othy, +7 authors, Michael D Cahalan.
Nat Commun, 2015 Feb 06; 6. PMID: 25653051    Free PMC article.
CTLA4 polymorphisms and de novo malignancy risk after renal transplantation in Chinese recipients.
Yi-feng Guo, Jian-xin Qiu, +2 authors, Ming-hua Shang.
Biomed Res Int, 2015 Feb 11; 2015. PMID: 25667935    Free PMC article.
Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation.
Hui Zhang, Shuang Wang, +5 authors, Shu Man Fu.
Clin Immunol, 2015 Feb 15; 157(2). PMID: 25680967    Free PMC article.
Immunotherapeutic advancements for glioblastoma.
Leonel Ampie, Eric C Woolf, Christopher Dardis.
Front Oncol, 2015 Feb 18; 5. PMID: 25688335    Free PMC article.
Review.
Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.
Ashley E Mahne, Joanna E Klementowicz, +2 authors, Qizhi Tang.
J Immunol, 2015 Mar 04; 194(7). PMID: 25732730    Free PMC article.
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Stephen M Hatfield, Jorgen Kjaergaard, +15 authors, Michail V Sitkovsky.
Sci Transl Med, 2015 Mar 06; 7(277). PMID: 25739764    Free PMC article.
Highly Cited.
Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.
Maxime Dhainaut, Caroline Coquerelle, +10 authors, Muriel Moser.
EMBO J, 2015 Mar 20; 34(10). PMID: 25787857    Free PMC article.
Harnessing regulatory T cells for the treatment of inflammatory bowel disease.
Duke Geem, Akihito Harusato, Kyle Flannigan, Timothy L Denning.
Inflamm Bowel Dis, 2015 Mar 21; 21(6). PMID: 25793328    Free PMC article.
Review.
Regulatory T cells require TCR signaling for their suppressive function.
Amanda M Schmidt, Wen Lu, +7 authors, Taku Kambayashi.
J Immunol, 2015 Mar 31; 194(9). PMID: 25821220    Free PMC article.
Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes.
Kazunari Kaneko, Shoji Tsuji, +3 authors, Shogo Kato.
World J Pediatr, 2015 Mar 31; 11(1). PMID: 25822700
Review.
Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients.
Maria Napolitano, Crescenzo D'Alterio, +11 authors, Stefania Scala.
Oncotarget, 2015 Apr 01; 6(10). PMID: 25823653    Free PMC article.
CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis.
Hyun-Bae Jie, Patrick J Schuler, +5 authors, Robert L Ferris.
Cancer Res, 2015 Apr 03; 75(11). PMID: 25832655    Free PMC article.
Highly Cited.
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Jeremy A Goettel, Subhabrata Biswas, +21 authors, Scott B Snapper.
Blood, 2015 Apr 03; 125(25). PMID: 25833964    Free PMC article.
Anti-programmed cell death protein-1/ligand-1 therapy in different cancers.
B Homet Moreno, A Ribas.
Br J Cancer, 2015 Apr 10; 112(9). PMID: 25856776    Free PMC article.
Highly Cited. Review.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
Suzanne L Topalian, Charles G Drake, Drew M Pardoll.
Cancer Cell, 2015 Apr 11; 27(4). PMID: 25858804    Free PMC article.
Highly Cited. Review.
Tissue resident regulatory T cells: novel therapeutic targets for human disease.
Xiaohui Zhou, Jiayou Tang, +2 authors, Bin Li.
Cell Mol Immunol, 2015 Apr 22; 12(5). PMID: 25891216    Free PMC article.
Review.
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients.
Emanuela Romano, Monika Kusio-Kobialka, +7 authors, Daniel E Speiser.
Proc Natl Acad Sci U S A, 2015 Apr 29; 112(19). PMID: 25918390    Free PMC article.
Highly Cited.
The glomerular permeability factors in idiopathic nephrotic syndrome.
Jean-Claude Davin.
Pediatr Nephrol, 2015 May 01; 31(2). PMID: 25925039    Free PMC article.
Review.
The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies.
Haoqing Shi, Xiangjie Qi, +4 authors, Haitao Niu.
Chin J Cancer Res, 2015 May 06; 27(2). PMID: 25937774    Free PMC article.
Review.
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell.
Comput Struct Biotechnol J, 2015 May 06; 13. PMID: 25941561    Free PMC article.
Highly Cited. Review.
Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.
Hanna A Knaus, Christopher G Kanakry, Leo Luznik, Ivana Gojo.
Curr Drug Targets, 2015 May 20; 18(3). PMID: 25981611    Free PMC article.
Review.
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade.
Frederick J Kohlhapp, Joseph R Broucek, +16 authors, Howard L Kaufman.
J Immunother Cancer, 2015 May 21; 3. PMID: 25992289    Free PMC article.
Donor Requirements for Regulatory T Cell Suppression of Murine Graft-versus-Host Disease.
Antonio Pierini, Lucrezia Colonna, +7 authors, Robert S Negrin.
J Immunol, 2015 May 23; 195(1). PMID: 25994967    Free PMC article.
Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.
Alice O Kamphorst, Koichi Araki, Rafi Ahmed.
Vaccine, 2015 May 30; 33 Suppl 2. PMID: 26022562    Free PMC article.
Review.
The functional and prognostic implications of regulatory T cells in colorectal carcinoma.
Xinhai Zhang, Sonia Kelaria, Justin Kerstetter, Jun Wang.
J Gastrointest Oncol, 2015 Jun 02; 6(3). PMID: 26029458    Free PMC article.
Review.
Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance.
Sylvaine You.
Front Immunol, 2015 Jun 05; 6. PMID: 26042125    Free PMC article.
Review.
Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function.
Cesar M Rueda, Maria E Moreno-Fernandez, +3 authors, Claire A Chougnet.
Eur J Immunol, 2015 Jun 06; 45(9). PMID: 26046326    Free PMC article.
Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy.
Jashodeep Datta, Erik Berk, +3 authors, Brian J Czerniecki.
Front Immunol, 2015 Jun 18; 6. PMID: 26082780    Free PMC article.
Review.
T follicular regulatory cells in the regulation of B cell responses.
Peter T Sage, Arlene H Sharpe.
Trends Immunol, 2015 Jun 21; 36(7). PMID: 26091728    Free PMC article.
Highly Cited. Review.
CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells.
Pablo Penaloza-MacMaster, Nicholas M Provine, Eryn Blass, Dan H Barouch.
J Immunol, 2015 Jun 28; 195(3). PMID: 26116499    Free PMC article.
Non-Small-Cell Lung Cancer: Role of the Immune System and Potential for Immunotherapy.
David P Carbone, David R Gandara, +2 authors, Luis Paz-Ares.
J Thorac Oncol, 2015 Jul 03; 10(7). PMID: 26134219    Free PMC article.
Review.
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
Louisa E Jeffery, Omar S Qureshi, +6 authors, David M Sansom.
PLoS One, 2015 Jul 03; 10(7). PMID: 26134669    Free PMC article.
Modulating effects of leflunomide on the balance of Th17/Treg cells in collageninduced arthritis DBA/1 mice.
Ming Zhu, Qi Xu, +2 authors, Wei-Feng Wang.
Cent Eur J Immunol, 2014 Jan 01; 39(2). PMID: 26155116    Free PMC article.
Clinical Development of Immune Checkpoint Inhibitors.
Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407    Free PMC article.
Review.
Beyond the Immune Suppression: The Immunotherapy in Prostate Cancer.
Ida Silvestri, Susanna Cattarino, +2 authors, Alessandro Sciarra.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161414    Free PMC article.
Review.
Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment.
Shuping Zhang, Xing Ke, +7 authors, Shiyang Pan.
Cell Mol Immunol, 2015 Jul 15; 12(5). PMID: 26166762    Free PMC article.
Inhibitory Receptors Beyond T Cell Exhaustion.
Silvia A Fuertes Marraco, Natalie J Neubert, Grégory Verdeil, Daniel E Speiser.
Front Immunol, 2015 Jul 15; 6. PMID: 26167163    Free PMC article.
Highly Cited. Review.
Immunotherapy for Bone and Soft Tissue Sarcomas.
Takenori Uehara, Tomohiro Fujiwara, +3 authors, Heiichiro Udono.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26167500    Free PMC article.
Review.
Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab.
Saskia Jam Santegoets, Anita Gm Stam, +9 authors, Tanja D de Gruijl.
J Immunother Cancer, 2014 Jan 01; 2. PMID: 26196012    Free PMC article.
Engineering an "infectious" T(reg) biomimetic through chemoselective tethering of TGF-β1 to PEG brush surfaces.
E Y Yang, J P Kronenfeld, +2 authors, C L Stabler.
Biomaterials, 2015 Jul 22; 67. PMID: 26197412    Free PMC article.
Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention.
Aaron Michels, Li Zhang, +3 authors, Massimo Pietropaolo.
Pediatr Diabetes, 2015 Jul 24; 16(7). PMID: 26202050    Free PMC article.
Review.
Noncoding RNAs and chronic inflammation: Micro-managing the fire within.
Margaret Alexander, Ryan M O'Connell.
Bioessays, 2015 Aug 08; 37(9). PMID: 26249326    Free PMC article.
Review.
Research Progress on Regulatory T Cells in Acute Kidney Injury.
Yamei Wang, Yuhong Tao.
J Immunol Res, 2015 Aug 15; 2015. PMID: 26273681    Free PMC article.
Review.
Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.
Holly A Bolton, Erhua Zhu, +9 authors, Barbara Fazekas de St Groth.
J Clin Invest, 2015 Aug 25; 125(9). PMID: 26301814    Free PMC article.
Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
Takashi Sekiya, Taisuke Kondo, +3 authors, Akihiko Yoshimura.
J Exp Med, 2015 Aug 26; 212(10). PMID: 26304965    Free PMC article.
PD-1: Dual guard for immunopathology.
Hye Ryun Kim, Hyo Jin Park, Sang-Jun Ha.
Oncotarget, 2015 Sep 01; 6(26). PMID: 26318040    Free PMC article.
Cancer and the Immune System: Basic Concepts and Targets for Intervention.
Drew Pardoll.
Semin Oncol, 2015 Sep 01; 42(4). PMID: 26320058    Free PMC article.
Highly Cited. Review.
Defects in Germinal Center Selection in SLE.
Megan Woods, Yong-Rui Zou, Anne Davidson.
Front Immunol, 2015 Sep 01; 6. PMID: 26322049    Free PMC article.
Review.
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade.
Elizabeth Buchbinder, F Stephen Hodi.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325034    Free PMC article.
Review.
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.
Lieping Chen, Xue Han.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325035    Free PMC article.
Highly Cited. Review.
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.
Nikhil S Joshi, Elliot H Akama-Garren, +11 authors, Tyler Jacks.
Immunity, 2015 Sep 06; 43(3). PMID: 26341400    Free PMC article.
Highly Cited.
Control of Regulatory T Cell Migration, Function, and Homeostasis.
Daniel J Campbell.
J Immunol, 2015 Sep 06; 195(6). PMID: 26342103    Free PMC article.
Highly Cited. Review.
Immunosuppression associated with chronic inflammation in the tumor microenvironment.
Dingzhi Wang, Raymond N DuBois.
Carcinogenesis, 2015 Sep 12; 36(10). PMID: 26354776    Free PMC article.
Highly Cited. Review.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Alison M Paterson, Scott B Lovitch, +9 authors, Arlene H Sharpe.
J Exp Med, 2015 Sep 16; 212(10). PMID: 26371185    Free PMC article.
Highly Cited.
Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus.
Valentina Perri, Benedetta Russo, +5 authors, Alessandra Fierabracci.
Int J Mol Sci, 2015 Sep 24; 16(9). PMID: 26393578    Free PMC article.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Alan Serrels, Tom Lund, +15 authors, Margaret C Frame.
Cell, 2015 Sep 26; 163(1). PMID: 26406376    Free PMC article.
Highly Cited.
TIGIT predominantly regulates the immune response via regulatory T cells.
Sema Kurtulus, Kaori Sakuishi, +6 authors, Ana C Anderson.
J Clin Invest, 2015 Sep 29; 125(11). PMID: 26413872    Free PMC article.
Highly Cited.
Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Junko Nishio, Minato Baba, +7 authors, Tadatsugu Taniguchi.
Proc Natl Acad Sci U S A, 2015 Oct 01; 112(41). PMID: 26420876    Free PMC article.
A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse.
Fabian Jakubczik, Ken Jones, +3 authors, Nick Holmes.
Diabetes, 2015 Oct 10; 65(1). PMID: 26450994    Free PMC article.
Immune checkpoint inhibitors: a new frontier in bladder cancer.
Max Kates, Nikolai A Sopko, +3 authors, Trinity J Bivalacqua.
World J Urol, 2015 Oct 22; 34(1). PMID: 26487055
Review.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy.
Kelly Kersten, Camilla Salvagno, Karin E de Visser.
Front Immunol, 2015 Oct 27; 6. PMID: 26500653    Free PMC article.
Review.
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition.
Elizabeth I Buchbinder, Anupam Desai.
Am J Clin Oncol, 2015 Nov 13; 39(1). PMID: 26558876    Free PMC article.
Highly Cited. Review.
Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.
Anna Śledzińska, Laurie Menger, +2 authors, Sergio A Quezada.
Mol Oncol, 2015 Nov 19; 9(10). PMID: 26578451    Free PMC article.
Review.
Depletion of fat-resident Treg cells prevents age-associated insulin resistance.
Sagar P Bapat, Jae Myoung Suh, +12 authors, Ye Zheng.
Nature, 2015 Nov 19; 528(7580). PMID: 26580014    Free PMC article.
Highly Cited.
GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.
Alexander Pedroza-Gonzalez, Guoying Zhou, +11 authors, Dave Sprengers.
Oncoimmunology, 2015 Nov 21; 4(12). PMID: 26587321    Free PMC article.
CTLA-4 and Autoimmunity: New Twists in the Tale.
Lucy S K Walker.
Trends Immunol, 2015 Nov 26; 36(12). PMID: 26596798    Free PMC article.
Role of immune tolerance in BALB/c mice with anaphylactic shock after Echinococcus granulosus infection.
Qin Zhang, Jian-Rong Ye, +3 authors, Hong Zheng.
Immunol Res, 2015 Nov 26; 64(1). PMID: 26603168
Immune homeostasis enforced by co-localized effector and regulatory T cells.
Zhiduo Liu, Michael Y Gerner, +3 authors, Ronald N Germain.
Nature, 2015 Nov 26; 528(7581). PMID: 26605524    Free PMC article.
Highly Cited.
The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection.
Laura E Richert-Spuhler, Jennifer M Lund.
Prog Mol Biol Transl Sci, 2015 Nov 29; 136. PMID: 26615099    Free PMC article.
Review.
Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy.
Silvia Gregori, Laura Passerini, Maria-Grazia Roncarolo.
Front Immunol, 2015 Dec 05; 6. PMID: 26635807    Free PMC article.
Review.
Variation in the CTLA4 3'UTR has phenotypic consequences for autoreactive T cells and associates with genetic risk for type 1 diabetes.
V M de Jong, A Zaldumbide, +3 authors, B O Roep.
Genes Immun, 2015 Dec 15; 17(1). PMID: 26656450
Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.
Uri Sela, Chae Gyu Park, +4 authors, Vincent A Fischetti.
PLoS One, 2016 Jan 09; 11(1). PMID: 26745371    Free PMC article.
The thymus and rheumatology: should we care?
Emilie Cosway, Graham Anderson, Paul Garside, Catriona Prendergast.
Curr Opin Rheumatol, 2016 Jan 12; 28(2). PMID: 26751840    Free PMC article.
Review.
Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.
Antonio Pierini, Dominik Schneidawind, Hidekazu Nishikii, Robert S Negrin.
Curr Stem Cell Rep, 2016 Jan 19; 1(4). PMID: 26779417    Free PMC article.
Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.
Shu Liu, Xiangdong Sun, +5 authors, Xinchen Sun.
Am J Cancer Res, 2016 Jan 26; 5(11). PMID: 26807310    Free PMC article.
Review.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.
Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod.
World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641    Free PMC article.
Review.
Inducing and Administering Tregs to Treat Human Disease.
Ana Luisa Perdigoto, Lucienne Chatenoud, Jeffrey A Bluestone, Kevan C Herold.
Front Immunol, 2016 Feb 03; 6. PMID: 26834735    Free PMC article.
Review.
Advances in immunotherapy for melanoma.
Jason M Redman, Geoffrey T Gibney, Michael B Atkins.
BMC Med, 2016 Feb 07; 14. PMID: 26850630    Free PMC article.
Highly Cited. Review.
Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa.
Christina Ballke, Einar Gran, Espen S Baekkevold, Frode L Jahnsen.
PLoS One, 2016 Feb 13; 11(2). PMID: 26866695    Free PMC article.
Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.
Joanna Brzostek, Nicholas R J Gascoigne, Vasily Rybakin.
Front Immunol, 2016 Feb 13; 7. PMID: 26870040    Free PMC article.
Review.
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm.
Kiyoshi Hirahara, Toshinori Nakayama.
Int Immunol, 2016 Feb 14; 28(4). PMID: 26874355    Free PMC article.
Highly Cited. Review.
NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell Engraftment.
Antonio Pierini, Maite Alvarez, Robert S Negrin.
Stem Cells Int, 2016 Feb 18; 2016. PMID: 26880996    Free PMC article.
Review.
Contemplating autoimmunity in the Aegean islands.
Lucy S K Walker, Steven Ziegler, Burkhard Becher.
Nat Immunol, 2016 Feb 18; 17(3). PMID: 26882250
Ipilimumab (Anti-Ctla-4 Mab) in the treatment of metastatic melanoma: Effectiveness and toxicity management.
Paola Savoia, Chiara Astrua, Paolo Fava.
Hum Vaccin Immunother, 2016 Feb 19; 12(5). PMID: 26889818    Free PMC article.
Review.
A novel multi-drug metronomic chemotherapy significantly delays tumor growth in mice.
Maria Tagliamonte, Annacarmen Petrizzo, +9 authors, Luigi Buonaguro.
J Transl Med, 2016 Feb 26; 14. PMID: 26911136    Free PMC article.
T Regulatory Cell Biology in Health and Disease.
Fayhan J Alroqi, Talal A Chatila.
Curr Allergy Asthma Rep, 2016 Mar 01; 16(4). PMID: 26922942    Free PMC article.
Review.
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
Nobumasa Watanabe, Osamu Kaminuma, Noriko Kitamura, Takachika Hiroi.
PLoS One, 2016 Mar 08; 11(3). PMID: 26950218    Free PMC article.
Dexamethasone attenuates echinococcosis-induced allergic reactions via regulatory T cells in mice.
Qin Zhang, Jianrong Ye, Hong Zheng.
BMC Immunol, 2016 Mar 13; 17. PMID: 26968945    Free PMC article.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.
Matthew M Halpert, Vanaja Konduri, +5 authors, William K Decker.
Stem Cells Dev, 2016 Mar 17; 25(10). PMID: 26979751    Free PMC article.
Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment.
Stefani Spranger.
Int Immunol, 2016 Mar 19; 28(8). PMID: 26989092    Free PMC article.
Highly Cited. Review.
Regulatory T cells are essential to promote proper CD4 T-cell priming upon mucosal infection.
A G Soerens, A Da Costa, J M Lund.
Mucosal Immunol, 2016 Mar 24; 9(6). PMID: 27007674    Free PMC article.
Immunotherapy for cancer in the central nervous system: Current and future directions.
David C Binder, Andrew A Davis, Derek A Wainwright.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057463    Free PMC article.
Highly Cited. Review.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.
Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, Kajsa Wing.
Proc Natl Acad Sci U S A, 2016 Apr 14; 113(17). PMID: 27071130    Free PMC article.
Highly Cited.
Development and maintenance of intestinal regulatory T cells.
Takeshi Tanoue, Koji Atarashi, Kenya Honda.
Nat Rev Immunol, 2016 Apr 19; 16(5). PMID: 27087661
Highly Cited. Review.
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.
Liping Sun, Hao Jin, Hui Li.
Oncotarget, 2016 Apr 21; 7(27). PMID: 27095576    Free PMC article.
Review.
Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival.
Christopher M Borges, Dawn K Reichenbach, +3 authors, Laurence A Turka.
Transpl Int, 2016 Apr 27; 29(8). PMID: 27112509    Free PMC article.
PD-L1 Expression in Lung Cancer.
Hui Yu, Theresa A Boyle, +2 authors, Fred R Hirsch.
J Thorac Oncol, 2016 Apr 28; 11(7). PMID: 27117833    Free PMC article.
Highly Cited. Review.
CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor.
X-Y Qin, Y Wang, +11 authors, X-J Huang.
J Transl Med, 2016 Apr 28; 14. PMID: 27118383    Free PMC article.
Immune based therapy for melanoma.
Robert Ancuceanu, Monica Neagu.
Indian J Med Res, 2016 Apr 29; 143(2). PMID: 27121512    Free PMC article.
Review.
Phenotypical characterization of regulatory T cells in humans and rodents.
A L Rodríguez-Perea, E D Arcia, C M Rueda, P A Velilla.
Clin Exp Immunol, 2016 Apr 29; 185(3). PMID: 27124481    Free PMC article.
Review.
Anti-CD28 Antibody and Belatacept Exert Differential Effects on Mechanisms of Renal Allograft Rejection.
Simon Ville, Nicolas Poirier, +13 authors, Gilles Blancho.
J Am Soc Nephrol, 2016 May 11; 27(12). PMID: 27160407    Free PMC article.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
Adam N Odeh, Jerry W Simecka.
PLoS One, 2016 May 14; 11(5). PMID: 27175511    Free PMC article.
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Frank A Schildberg, Sarah R Klein, Gordon J Freeman, Arlene H Sharpe.
Immunity, 2016 May 19; 44(5). PMID: 27192563    Free PMC article.
Highly Cited. Review.
CD28 Costimulation: From Mechanism to Therapy.
Jonathan H Esensten, Ynes A Helou, +2 authors, Jeffrey A Bluestone.
Immunity, 2016 May 19; 44(5). PMID: 27192564    Free PMC article.
Highly Cited. Review.
Monoclonal regulatory T cells provide insights into T cell suppression.
Céline Gubser, Mathias Schmaler, Simona W Rossi, Ed Palmer.
Sci Rep, 2016 May 24; 6. PMID: 27210828    Free PMC article.
Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Ruth J Davis, Carter Van Waes, Clint T Allen.
Oral Oncol, 2016 May 25; 58. PMID: 27215705    Free PMC article.
Review.
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
Hristina Nedelkovska, Alexander F Rosenberg, +9 authors, Steven H Bernstein.
PLoS One, 2016 May 27; 11(5). PMID: 27228053    Free PMC article.
Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules.
Sreenivas Gannavaram, Parna Bhattacharya, +3 authors, Hira L Nakhasi.
Front Immunol, 2016 Jun 01; 7. PMID: 27242794    Free PMC article.
Review.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression.
Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion.
Front Immunol, 2016 Jun 01; 7. PMID: 27242797    Free PMC article.
Review.
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression.
Emily R Mercadante, Ulrike M Lorenz.
Front Immunol, 2016 Jun 01; 7. PMID: 27242798    Free PMC article.
Review.
A second chance for telomerase reverse transcriptase in anticancer immunotherapy.
Maurizio Zanetti.
Nat Rev Clin Oncol, 2016 Nov 03; 14(2). PMID: 27245281
Review.
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung.
J Immunol, 2016 Jun 05; 197(1). PMID: 27259856    Free PMC article.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
Xin Li, Nicole V Acuff, +4 authors, Wendy T Watford.
J Biol Chem, 2016 Jun 05; 291(32). PMID: 27261457    Free PMC article.
Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4+ regulatory T cell subsets circulating in human malaria.
Raquel M Gonçalves-Lopes, Nathália F Lima, +3 authors, Marcelo U Ferreira.
Microbes Infect, 2016 Jun 21; 18(10). PMID: 27320393    Free PMC article.
Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab.
Janet Retseck, Robert VanderWeele, +3 authors, Ahmad A Tarhini.
J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330811    Free PMC article.
Insights into the development and regulation of T follicular helper cells.
Shradha Wali, Anupama Sahoo, +2 authors, Roza Nurieva.
Cytokine, 2016 Jun 25; 87. PMID: 27339151    Free PMC article.
Review.
CTLA-4 Limits Anti-CD20-Mediated Tumor Regression.
Zhenhua Ren, Jingya Guo, +7 authors, Yang-Xin Fu.
Clin Cancer Res, 2016 Jun 30; 23(1). PMID: 27354469    Free PMC article.
Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates.
Lisa Gamrad, Christoph Rehbock, +3 authors, Wiebke Hansen.
Sci Rep, 2016 Jul 07; 6. PMID: 27381215    Free PMC article.
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.
Baihao Zhang, Shunsuke Chikuma, +2 authors, Tasuku Honjo.
Proc Natl Acad Sci U S A, 2016 Jul 14; 113(30). PMID: 27410049    Free PMC article.
Highly Cited.
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency.
Bernice Lo, Jill M Fritz, +3 authors, Michael J Lenardo.
Blood, 2016 Jul 16; 128(8). PMID: 27418640    Free PMC article.
Review.
The balance between Foxp3 and Ror-γt expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis.
Yoshifumi Tada, Nobuyuki Ono, +8 authors, Syuichi Koarada.
BMC Musculoskelet Disord, 2016 Jul 17; 17. PMID: 27421886    Free PMC article.
Drug discovery in advanced prostate cancer: translating biology into therapy.
Timothy A Yap, Alan D Smith, +3 authors, Johann S de Bono.
Nat Rev Drug Discov, 2016 Jul 23; 15(10). PMID: 27444228
Review.
Maraviroc decreases CCL8-mediated migration of CCR5(+) regulatory T cells and reduces metastatic tumor growth in the lungs.
E C Halvorsen, M J Hamilton, +6 authors, K L Bennewith.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471618    Free PMC article.
Stabilization of high-risk plaques.
Kohei Takata, Satoshi Imaizumi, +2 authors, Keijiro Saku.
Cardiovasc Diagn Ther, 2016 Aug 09; 6(4). PMID: 27500090    Free PMC article.
Review.
Novel melanoma therapy.
Eddy C Hsueh, Kalyan C Gorantla.
Exp Hematol Oncol, 2015 Jan 01; 5. PMID: 27508107    Free PMC article.
Review.
Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation.
Alison C Billroth-MacLurg, Jill Ford, +2 authors, Deborah J Fowell.
J Immunol, 2016 Aug 12; 197(6). PMID: 27511734    Free PMC article.
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.
Benjamin Herzberg, Meghan J Campo, Justin F Gainor.
Oncologist, 2016 Aug 19; 22(1). PMID: 27534574    Free PMC article.
Review.
IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release.
Julia Siede, Anja Fröhlich, +6 authors, Max Löhning.
PLoS One, 2016 Aug 23; 11(8). PMID: 27548066    Free PMC article.
Baicalein induces CD4(+)Foxp3(+) T cells and enhances intestinal barrier function in a mouse model of food allergy.
Min-Jung Bae, Hee Soon Shin, +3 authors, Dong-Hwa Shon.
Sci Rep, 2016 Aug 27; 6. PMID: 27561877    Free PMC article.
Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells.
Xiaoyin Niu, Shaohua Deng, +6 authors, Guangjie Chen.
Mol Med, 2016 Sep 01; 22. PMID: 27579476    Free PMC article.
Regulatory T Cells: Differentiation and Function.
George Plitas, Alexander Y Rudensky.
Cancer Immunol Res, 2016 Sep 04; 4(9). PMID: 27590281    Free PMC article.
Highly Cited. Review.
Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway.
Andrew B Adams, Mandy L Ford, Christian P Larsen.
J Immunol, 2016 Sep 04; 197(6). PMID: 27591335    Free PMC article.
Review.
Regulatory T cells in allergic diseases.
Magali Noval Rivas, Talal A Chatila.
J Allergy Clin Immunol, 2016 Sep 07; 138(3). PMID: 27596705    Free PMC article.
Highly Cited. Review.
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
Mark J Selby, John J Engelhardt, +11 authors, Alan J Korman.
PLoS One, 2016 Sep 10; 11(9). PMID: 27610613    Free PMC article.
Highly Cited.
Microbiota, regulatory T cell subsets, and allergic disorders.
Caspar Ohnmacht.
Allergo J Int, 2016 Sep 23; 25(5). PMID: 27656354    Free PMC article.
Restoring Regulatory T Cells in Type 1 Diabetes.
Allyson Spence, Qizhi Tang.
Curr Diab Rep, 2016 Sep 25; 16(11). PMID: 27664043
Review.
Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease.
Nadine Kuttkat, Antje Mohs, +5 authors, Christian Trautwein.
Gut, 2016 Oct 01; 66(5). PMID: 27686093    Free PMC article.
Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization.
Nina Pilat, Benedikt Mahr, +6 authors, Thomas Wekerle.
JCI Insight, 2016 Oct 05; 1(7). PMID: 27699263    Free PMC article.
Modulation of Phenotype and Function of Human CD4+CD25+ T Regulatory Lymphocytes Mediated by cAMP-Elevating Agents.
Antonella Riccomi, Valentina Gesa, +2 authors, Silvia Vendetti.
Front Immunol, 2016 Oct 06; 7. PMID: 27703455    Free PMC article.
FOXP3+ associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients.
Jian-Guo Zhang, Xiao-Juan Chen, Tao Liu, Shu-Juan Jiang.
Exp Ther Med, 2016 Oct 06; 12(4). PMID: 27703517    Free PMC article.
Regulatory T Cells in SLE: Biology and Use in Treatment.
Sophia Giang, Antonio La Cava.
Curr Rheumatol Rep, 2016 Oct 06; 18(11). PMID: 27704250
Review.
Regulatory T-Cell Therapy for Graft-versus-host Disease.
Jessica Heinrichs, David Bastian, +3 authors, Xue-Zhong Yu.
J Immunol Res Ther, 2016 Oct 11; 1(1). PMID: 27722210    Free PMC article.
Targeting immune checkpoints in malignant glioma.
Xuhao Zhang, Shan Zhu, +3 authors, Jingtao Chen.
Oncotarget, 2016 Oct 21; 8(4). PMID: 27756892    Free PMC article.
Review.
Immunotherapy in urothelial carcinoma: fade or future standard?
Johannes Breyer, Maximilian Burger, Wolfgang Otto.
Transl Androl Urol, 2016 Oct 28; 5(5). PMID: 27785423    Free PMC article.
Review.
Co-stimulation Blockade Plus T-Cell Depletion in Transplant Patients: Towards a Steroid- and Calcineurin Inhibitor-Free Future?
Florence Herr, Melanie Brunel, Nathalie Roders, Antoine Durrbach.
Drugs, 2016 Oct 28; 76(17). PMID: 27785759
Review.
Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.
Andrew Jones, Jessica Bourque, +4 authors, Daniel Hawiger.
Immunity, 2016 Oct 30; 45(5). PMID: 27793593    Free PMC article.
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells.
Masahiro Hirakawa, Tiago R Matos, +16 authors, Jerome Ritz.
JCI Insight, 2016 Nov 05; 1(18). PMID: 27812545    Free PMC article.
Checkpoint Proteins in Pediatric Brain and Extracranial Solid Tumors: Opportunities for Immunotherapy.
Eric K Ring, James M Markert, G Yancey Gillespie, Gregory K Friedman.
Clin Cancer Res, 2016 Nov 12; 23(2). PMID: 27836863    Free PMC article.
Review.
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Charis E Teh, Najoua Lalaoui, +18 authors, Daniel H D Gray.
Nat Commun, 2016 Nov 20; 7. PMID: 27857075    Free PMC article.
Immune modulation of CD4+CD25+ regulatory T cells by zoledronic acid.
Hsien Liu, Shih-Han Wang, +3 authors, Tsun-Mei Lin.
BMC Immunol, 2016 Nov 27; 17(1). PMID: 27887569    Free PMC article.
Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis.
Barbara Rossi, Gabriela Constantin.
Front Immunol, 2016 Dec 06; 7. PMID: 27917173    Free PMC article.
Review.
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells.
Da-Wei Wang, Ning Dong, +3 authors, Yong-Ming Yao.
Sci Rep, 2016 Dec 13; 6. PMID: 27941849    Free PMC article.
Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia.
James W Swann, Kelly Woods, +2 authors, Oliver A Garden.
PLoS One, 2016 Dec 13; 11(12). PMID: 27942026    Free PMC article.
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Yohko Kitagawa, Naganari Ohkura, +10 authors, Shimon Sakaguchi.
Nat Immunol, 2016 Dec 20; 18(2). PMID: 27992401    Free PMC article.
Highly Cited.
Regulatory T cells in cancer immunotherapy.
Atsushi Tanaka, Shimon Sakaguchi.
Cell Res, 2016 Dec 21; 27(1). PMID: 27995907    Free PMC article.
Highly Cited. Review.
Radiotherapy and immune checkpoint blockades: a snapshot in 2016.
Taeryool Koo, In Ah Kim.
Radiat Oncol J, 2016 Dec 30; 34(4). PMID: 28030901    Free PMC article.
Review.
A New VISTA on combination therapy for negative checkpoint regulator blockade.
Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J Noelle.
J Immunother Cancer, 2016 Dec 30; 4. PMID: 28031817    Free PMC article.
Review.
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.
Michael P Holt, George A Punkosdy, Deborah D Glass, Ethan M Shevach.
J Immunol, 2017 Jan 06; 198(4). PMID: 28053234    Free PMC article.
An expanding stage for commensal microbes in host immune regulation.
Yan Shi, Libing Mu.
Cell Mol Immunol, 2017 Jan 10; 14(4). PMID: 28065939    Free PMC article.
Review.
T cell exhaustion: from pathophysiological basics to tumor immunotherapy.
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger.
Cell Commun Signal, 2017 Jan 12; 15(1). PMID: 28073373    Free PMC article.
Highly Cited. Review.
Negative Regulation of Type 2 Immunity.
Dimitri A de Kouchkovsky, Sourav Ghosh, Carla V Rothlin.
Trends Immunol, 2017 Jan 14; 38(3). PMID: 28082101    Free PMC article.
Review.
Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.
Jiahuan Chen, Anutosh Ganguly, +14 authors, Yan Shi.
J Exp Med, 2017 Jan 14; 214(2). PMID: 28082358    Free PMC article.
Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo.
Jiacong Yan, Bo Liu, Yan Shi, Hai Qi.
J Exp Med, 2017 Jan 14; 214(2). PMID: 28082359    Free PMC article.
Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy.
Henoch S Hong, Sven D Koch, +9 authors, James M Billingsley.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123889    Free PMC article.
Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives.
Grainne M O'Kane, Natasha B Leighl.
Transl Lung Cancer Res, 2017 Feb 06; 5(6). PMID: 28149757    Free PMC article.
Review.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Tie Zheng Hou, Nisha Verma, +17 authors, David M Sansom.
Blood, 2017 Feb 06; 129(11). PMID: 28159733    Free PMC article.
Tumor regulation of the tissue environment in the liver.
Tobias Eggert, Tim F Greten.
Pharmacol Ther, 2017 Feb 09; 173. PMID: 28167218    Free PMC article.
Review.
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma.
Antonio Miguel, Luis Sendra, +5 authors, Salvador F Aliño.
Onco Targets Ther, 2017 Feb 09; 10. PMID: 28176947    Free PMC article.
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Ruea-Yea Huang, Ariel Francois, +2 authors, Kunle Odunsi.
Oncoimmunology, 2017 Feb 16; 6(1). PMID: 28197366    Free PMC article.
Highly Cited.
T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.
Arielle Glatman Zaretsky, Christoph Konradt, +17 authors, Christopher A Hunter.
Cell Rep, 2017 Feb 24; 18(8). PMID: 28228257    Free PMC article.
Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.
Leslie S Kean, Laurence A Turka, Bruce R Blazar.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258702    Free PMC article.
Review.
Expression of GARP Is Increased in Tumor-Infiltrating Regulatory T Cells and Is Correlated to Clinicopathology of Lung Cancer Patients.
Hao Jin, Liping Sun, +2 authors, Hui Li.
Front Immunol, 2017 Mar 07; 8. PMID: 28261204    Free PMC article.
Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.
Ricardo C Ferreira, Daniel B Rainbow, +6 authors, John A Todd.
Clin Immunol, 2017 Mar 13; 179. PMID: 28284938    Free PMC article.
Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development.
István P Sugár, Jayajit Das, Ciriyam Jayaprakash, Stuart C Sealfon.
Biophys J, 2017 Mar 16; 112(5). PMID: 28297658    Free PMC article.
Current modalities in cancer immunotherapy: Immunomodulatory antibodies, CARs and vaccines.
Jason Lohmueller, Olivera J Finn.
Pharmacol Ther, 2017 Mar 23; 178. PMID: 28322974    Free PMC article.
Review.
Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma.
Jennifer D Moy, Jessica M Moskovitz, Robert L Ferris.
Eur J Cancer, 2017 Mar 23; 76. PMID: 28324750    Free PMC article.
Review.
IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients.
Rossana Tallerico, Costanza M Cristiani, +21 authors, Ennio Carbone.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344869    Free PMC article.
CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder.
Zeynep Yesim Kucuk, Louis-Marie Charbonnier, +2 authors, Jack J Bleesing.
J Allergy Clin Immunol, 2017 Apr 04; 140(3). PMID: 28366794    Free PMC article.
CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.
Pablo Penaloza-MacMaster.
Immunology, 2017 Apr 05; 151(2). PMID: 28375543    Free PMC article.
Review.
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Jake Wang, Curtis J Perry, +6 authors, Marcus Bosenberg.
Pigment Cell Melanoma Res, 2017 Apr 06; 30(4). PMID: 28379630    Free PMC article.
Highly Cited.
Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment.
Azharuddin Sajid Syed Khaja, Salman M Toor, +4 authors, Eyad Elkord.
Oncotarget, 2017 Apr 08; 8(20). PMID: 28388539    Free PMC article.
CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.
Carleigh A O'Brien, Christopher Overall, +7 authors, Tajie H Harris.
J Immunol, 2017 Apr 09; 198(10). PMID: 28389591    Free PMC article.
Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors.
Ornella Franzese, Francesco Torino, +5 authors, Stefania D'Atri.
Oncotarget, 2017 Apr 14; 8(25). PMID: 28404974    Free PMC article.
Review.
Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer.
Dennis O Adeegbe, Yan Liu, +22 authors, Kwok-Kin Wong.
Cancer Discov, 2017 Apr 15; 7(8). PMID: 28408401    Free PMC article.
Highly Cited.
Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.
Garima Garg, Eirini Nikolouli, +13 authors, Jochen Huehn.
Oncotarget, 2017 Apr 19; 8(22). PMID: 28415767    Free PMC article.
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.
Melita Irving, Romain Vuillefroy de Silly, +2 authors, George Coukos.
Front Immunol, 2017 Apr 20; 8. PMID: 28421069    Free PMC article.
Review.
T Regulatory Cells in Bone Remodelling.
Aline Bozec, Mario M Zaiss.
Curr Osteoporos Rep, 2017 Apr 23; 15(3). PMID: 28432597
Review.
iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells.
Songjie Cai, Jiangang Hou, +9 authors, Xiao-Kang Li.
Stem Cell Reports, 2017 Apr 25; 8(5). PMID: 28434942    Free PMC article.
Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses.
Nikolaos Patsoukis, Jessica D Weaver, +3 authors, Vassiliki A Boussiotis.
Front Immunol, 2017 Apr 27; 8. PMID: 28443090    Free PMC article.
Review.
Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis.
Sonja Reißig, Yilang Tang, +14 authors, Nadine Hövelmeyer.
Nat Commun, 2017 Apr 30; 8. PMID: 28452361    Free PMC article.
Progress and opportunities for enhancing the delivery and efficacy of checkpoint inhibitors for cancer immunotherapy.
David M Francis, Susan N Thomas.
Adv Drug Deliv Rev, 2017 Apr 30; 114. PMID: 28455187    Free PMC article.
Review.
Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.
Katarzyna Bocian, Ewelina Kiernozek, +3 authors, Nadzieja Drela.
Arch Immunol Ther Exp (Warsz), 2017 May 10; 65(6). PMID: 28477096    Free PMC article.
Review.
CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.
Katrin Klocke, Rikard Holmdahl, Kajsa Wing.
Immunology, 2017 May 13; 152(1). PMID: 28497863    Free PMC article.
Mechanisms of Immune Tolerance in Leukemia and Lymphoma.
Emily K Curran, James Godfrey, Justin Kline.
Trends Immunol, 2017 May 18; 38(7). PMID: 28511816    Free PMC article.
Review.
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Rebecca L Crepeau, Mandy L Ford.
Expert Opin Biol Ther, 2017 May 21; 17(8). PMID: 28525959    Free PMC article.
Review.
Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation.
Andrew Jones, Daniel Hawiger.
Front Immunol, 2017 May 26; 8. PMID: 28536579    Free PMC article.
Review.
Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.
Qing Zhao, Stacey N Harbour, +9 authors, Charles O Elson.
J Immunol, 2017 May 26; 199(1). PMID: 28539431    Free PMC article.
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival.
Sonja M Lacher, Julia Bruttger, +4 authors, Ari Waisman.
Cell Death Dis, 2017 May 26; 8(5). PMID: 28542128    Free PMC article.
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.
Hwei-Fang Tsai, Ping-Ning Hsu.
J Biomed Sci, 2017 May 27; 24(1). PMID: 28545567    Free PMC article.
Review.
Delivering safer immunotherapies for cancer.
Lauren Milling, Yuan Zhang, Darrell J Irvine.
Adv Drug Deliv Rev, 2017 May 27; 114. PMID: 28545888    Free PMC article.
Highly Cited. Review.
Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy.
Jingyu Zhang, Dai Liu, +4 authors, Jennifer D Wu.
Sci Adv, 2017 Jun 01; 3(5). PMID: 28560327    Free PMC article.
Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.
Awo Akosua Kesewa Layman, Guoping Deng, +7 authors, Paula M Oliver.
Nat Commun, 2017 Jun 06; 8. PMID: 28580955    Free PMC article.
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.
Themis Alissafi, Aggelos Banos, +8 authors, Panayotis Verginis.
J Clin Invest, 2017 Jun 06; 127(7). PMID: 28581446    Free PMC article.
Regulatory T Cells in Allergy and Asthma.
Elena Martín-Orozco, María Norte-Muñoz, Javier Martínez-García.
Front Pediatr, 2017 Jun 08; 5. PMID: 28589115    Free PMC article.
Review.
Immune deficiency and autoimmunity in patients with CTLA-4 (CD152) mutations.
N Verma, S O Burns, L S K Walker, D M Sansom.
Clin Exp Immunol, 2017 Jun 11; 190(1). PMID: 28600865    Free PMC article.
Review.
The Effect of TGF-β on Treg Cells in Adverse Pregnancy Outcome upon Toxoplasma gondii Infection.
Mingdong Zhao, Haixia Zhang, +3 authors, Xuemei Hu.
Front Microbiol, 2017 Jun 13; 8. PMID: 28603517    Free PMC article.
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Sebastian Peer, Gottfried Baier, Thomas Gruber.
Oncotarget, 2017 Jun 15; 8(26). PMID: 28611299    Free PMC article.
Selective CD28 Blockade Results in Superior Inhibition of Donor-Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4-Ig.
I R Badell, G M La Muraglia, +3 authors, M L Ford.
Am J Transplant, 2017 Jun 22; 18(1). PMID: 28637095    Free PMC article.
Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage.
Shuang Geng, Yiwei Zhong, +7 authors, Bin Wang.
Front Immunol, 2017 Jun 24; 8. PMID: 28638384    Free PMC article.
Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.
Maher G Nawaf, Maria H Ulvmar, +7 authors, Peter J L Lane.
J Immunol, 2017 Jun 25; 199(3). PMID: 28646041    Free PMC article.
CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases.
Erna-Elise Paulsen, Thomas K Kilvaer, +6 authors, Tom Donnem.
Cancer Immunol Immunother, 2017 Jul 15; 66(11). PMID: 28707078    Free PMC article.
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Frida Ewald Sander, Malin Nilsson, +11 authors, Anna Martner.
Cancer Immunol Immunother, 2017 Jul 20; 66(11). PMID: 28721449    Free PMC article.
Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer.
Jung-Eun Jang, Cristina H Hajdu, +3 authors, Dafna Bar-Sagi.
Cell Rep, 2017 Jul 21; 20(3). PMID: 28723561    Free PMC article.
Highly Cited.
Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.
Qi Wang, Jianwei He, +2 authors, Lieping Chen.
Sci Rep, 2017 Jul 22; 7(1). PMID: 28729608    Free PMC article.
The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells.
Alessandra Audia, Siobhan Conroy, Rainer Glass, Krishna P L Bhat.
Front Oncol, 2017 Jul 26; 7. PMID: 28740831    Free PMC article.
Review.
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer.
Clemence Granier, Eleonore De Guillebon, +7 authors, Eric Tartour.
ESMO Open, 2017 Aug 02; 2(2). PMID: 28761757    Free PMC article.
Highly Cited. Review.
Antigen-specific regulatory T-cell responses to intestinal microbiota.
E V Russler-Germain, S Rengarajan, C-S Hsieh.
Mucosal Immunol, 2017 Aug 03; 10(6). PMID: 28766556    Free PMC article.
Review.
Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression.
Li Yang, P Charles Lin.
Semin Cancer Biol, 2017 Aug 08; 47. PMID: 28782608    Free PMC article.
Review.
Dendritic Cells As Inducers of Peripheral Tolerance.
Courtney A Iberg, Andrew Jones, Daniel Hawiger.
Trends Immunol, 2017 Aug 23; 38(11). PMID: 28826942    Free PMC article.
Highly Cited. Review.
Regulatory T cells in acute and chronic kidney diseases.
Rahul Sharma, Gilbert R Kinsey.
Am J Physiol Renal Physiol, 2017 Sep 08; 314(5). PMID: 28877881    Free PMC article.
Review.
Tim-3, Lag-3, and TIGIT.
Nicole Joller, Vijay K Kuchroo.
Curr Top Microbiol Immunol, 2017 Sep 14; 410. PMID: 28900677    Free PMC article.
Review.
Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells.
Paul E Clavijo, Ellen C Moore, +6 authors, Clint T Allen.
Oncotarget, 2017 Sep 17; 8(34). PMID: 28915554    Free PMC article.
Profile of pembrolizumab in the treatment of head and neck squamous cell carcinoma: design development and place in therapy.
Sulsal Haque, Mahender Yellu, Jaskirat Randhawa, Nooshin Hashemi-Sadraei.
Drug Des Devel Ther, 2017 Sep 19; 11. PMID: 28919706    Free PMC article.
Review.
Targets for immunotherapy of liver cancer.
Tim F Greten, Bruno Sangro.
J Hepatol, 2017 Sep 20;. PMID: 28923358    Free PMC article.
Review.
Liver X receptor activation promotes differentiation of regulatory T cells.
Martin Herold, Johanna Breuer, +4 authors, Luisa Klotz.
PLoS One, 2017 Sep 20; 12(9). PMID: 28926619    Free PMC article.
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
Victor Tkachev, Scott N Furlan, +15 authors, Leslie S Kean.
Sci Transl Med, 2017 Sep 22; 9(408). PMID: 28931653    Free PMC article.
Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives.
Emanuele Rinninella, Lucia Cerrito, +4 authors, Antonio Gasbarrini.
J Clin Transl Hepatol, 2017 Sep 25; 5(3). PMID: 28936405    Free PMC article.
Review.
PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
Mohammad S Hossain, Ghada M Kunter, +5 authors, Edmund K Waller.
PLoS One, 2017 Sep 28; 12(9). PMID: 28953925    Free PMC article.
Checkpoint Inhibitors: Applications for Autoimmunity.
Anna S Tocheva, Adam Mor.
Curr Allergy Asthma Rep, 2017 Sep 29; 17(10). PMID: 28956259    Free PMC article.
Review.
Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment.
Yuki Muroyama, Thomas R Nirschl, +14 authors, Charles G Drake.
Cancer Immunol Res, 2017 Oct 04; 5(11). PMID: 28970196    Free PMC article.
Highly Cited.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Review.
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.
Isobel S Okoye, Michael Houghton, +2 authors, Shokrollah Elahi.
Front Immunol, 2017 Oct 17; 8. PMID: 29033936    Free PMC article.
Review.
Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes.
Ling Xiao, Belinda Van't Land, +3 authors, Johan Garssen.
Front Immunol, 2017 Oct 17; 8. PMID: 29033938    Free PMC article.
Review.
CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.
Colleen S McGary, Claire Deleage, +14 authors, Mirko Paiardini.
Immunity, 2017 Oct 19; 47(4). PMID: 29045906    Free PMC article.
Highly Cited.
Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy.
Laura Passerini, Rosa Bacchetta.
Front Immunol, 2017 Oct 28; 8. PMID: 29075264    Free PMC article.
Review.
Immune checkpoint inhibitors in renal cell carcinoma.
Kirsty Ross, Rob J Jones.
Clin Sci (Lond), 2017 Oct 29; 131(21). PMID: 29079639    Free PMC article.
Review.
Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats.
Salim Hamdani, Allan Thiolat, +8 authors, Caroline Pilon.
World J Gastroenterol, 2017 Nov 04; 23(38). PMID: 29097869    Free PMC article.
Cardiotoxicity of immune checkpoint inhibitors.
Gilda Varricchi, Maria Rosaria Galdiero, +5 authors, Carlo Gabriele Tocchetti.
ESMO Open, 2017 Nov 07; 2(4). PMID: 29104763    Free PMC article.
Highly Cited. Review.
Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells.
Chien-Hui Chien, Bor-Luen Chiang.
J Biomed Sci, 2017 Nov 21; 24(1). PMID: 29151021    Free PMC article.
Review.
Blockade of Treg Cell Differentiation and Function by the Interleukin-21-Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus.
Hiroshi Kato, Andras Perl.
Arthritis Rheumatol, 2017 Nov 22; 70(3). PMID: 29161463    Free PMC article.
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Madhav Kishore, Kenneth C P Cheung, +17 authors, Federica M Marelli-Berg.
Immunity, 2017 Nov 23; 47(5). PMID: 29166588    Free PMC article.
Highly Cited.
Dissecting the mechanisms involved in anti-human T-lymphocyte immunoglobulin (ATG)-induced tolerance in the setting of allogeneic stem cell transplantation - potential implications for graft versus host disease.
Katia Beider, David Naor, +9 authors, Arnon Nagler.
Oncotarget, 2017 Dec 07; 8(53). PMID: 29207601    Free PMC article.
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity.
Christophe Pedros, Ann J Canonigo-Balancio, Kok-Fai Kong, Amnon Altman.
JCI Insight, 2017 Dec 08; 2(23). PMID: 29212947    Free PMC article.
Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.
Kyle L O'Hagan, Stephen D Miller, Hyewon Phee.
Sci Rep, 2017 Dec 08; 7(1). PMID: 29213081    Free PMC article.
Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.
Jawaher Alsughayyir, Gavin J Pettigrew, Reza Motallebzadeh.
Front Immunol, 2017 Dec 09; 8. PMID: 29218052    Free PMC article.
Review.
Advances in T-cell checkpoint immunotherapy for head and neck squamous cell carcinoma.
Xinmeng Qi, Bo Jia, Xue Zhao, Dan Yu.
Onco Targets Ther, 2017 Dec 15; 10. PMID: 29238207    Free PMC article.
Review.
Immunotherapies for malignant glioma.
Vassiliki A Boussiotis, Alain Charest.
Oncogene, 2017 Dec 16; 37(9). PMID: 29242608    Free PMC article.
Review.
Review: Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis.
Yuya Kondo, Masahiro Yokosawa, +5 authors, Takayuki Sumida.
Arthritis Rheumatol, 2017 Dec 16; 70(5). PMID: 29245178    Free PMC article.
Review.
Autoimmunity and primary immunodeficiency: two sides of the same coin?
Reinhold E Schmidt, Bodo Grimbacher, Torsten Witte.
Nat Rev Rheumatol, 2017 Dec 20; 14(1). PMID: 29255211
Review.
Identification of key genes implicated in the suppressive function of human FOXP3+CD25+CD4+ regulatory T cells through the analysis of time‑series data.
Xiaofeng Bai, Hua Shi, +3 authors, Shuxiong Xu.
Mol Med Rep, 2017 Dec 30; 17(3). PMID: 29286140    Free PMC article.
Infiltration of effector regulatory T cells predicts poor prognosis of diffuse large B-cell lymphoma, not otherwise specified.
Shoko Nakayama, Taiji Yokote, +10 authors, Motomu Tsuji.
Blood Adv, 2018 Jan 04; 1(8). PMID: 29296965    Free PMC article.
P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells.
Jinyong Choi, David Randall Pease, +2 authors, Hyewon Phee.
Immunology, 2018 Jan 04; 154(2). PMID: 29297928    Free PMC article.
Synthetic Nanoparticles That Promote Tumor Necrosis Factor Receptor 2 Expressing Regulatory T Cells in the Lung and Resistance to Allergic Airways Inflammation.
Rohimah Mohamud, Jeanne S LeMasurier, +5 authors, Magdalena Plebanski.
Front Immunol, 2018 Jan 10; 8. PMID: 29312323    Free PMC article.
Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti-CD154-Treated Monkeys.
Tianshu Zhang, Agnes M Azimzadeh, +14 authors, Richard N Pierson.
Transplantation, 2018 Jan 11; 102(3). PMID: 29319621    Free PMC article.
Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy.
Tom Erkers, Arwen Stikvoort, Michael Uhlin.
Stem Cells Int, 2018 Jan 20; 2017. PMID: 29348758    Free PMC article.
Review.
Regulatory T Cell Metabolism in the Hepatic Microenvironment.
Rebecca Ellen Wawman, Helen Bartlett, Ye Htun Oo.
Front Immunol, 2018 Jan 24; 8. PMID: 29358934    Free PMC article.
Review.
Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.
Jason Miska, Jen Bon Lui, +7 authors, Zhibin Chen.
J Exp Med, 2018 Jan 28; 215(3). PMID: 29374027    Free PMC article.
Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo.
Clémence Roux, Gaëlle Saviane, +9 authors, Matthieu Rouleau.
Front Immunol, 2018 Feb 10; 8. PMID: 29422893    Free PMC article.
Inhibition of tumor growth by cancer vaccine combined with metronomic chemotherapy and anti-PD-1 in a pre-clinical setting.
Annacarmen Petrizzo, Angela Mauriello, +11 authors, Luigi Buonaguro.
Oncotarget, 2018 Feb 10; 9(3). PMID: 29423067    Free PMC article.
Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia.
Marina Wierz, Sandrine Pierson, +10 authors, Etienne Moussay.
Blood, 2018 Feb 15; 131(14). PMID: 29439955    Free PMC article.
Upconversion in photodynamic therapy: plumbing the depths.
Michael R Hamblin.
Dalton Trans, 2018 Feb 17; 47(26). PMID: 29451568    Free PMC article.
The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.
Yenkel Grinberg-Bleyer, Rachel Caron, +5 authors, Sankar Ghosh.
J Immunol, 2018 Feb 21; 200(7). PMID: 29459403    Free PMC article.
MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.
Mingfeng Zhang, Jeremy J Racine, +6 authors, Defu Zeng.
Proc Natl Acad Sci U S A, 2018 Feb 22; 115(10). PMID: 29463744    Free PMC article.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Rajani Ravi, Kimberly A Noonan, +13 authors, Atul Bedi.
Nat Commun, 2018 Feb 23; 9(1). PMID: 29467463    Free PMC article.
Highly Cited.
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy.
Xuexiang Du, Fei Tang, +14 authors, Yang Liu.
Cell Res, 2018 Feb 24; 28(4). PMID: 29472691    Free PMC article.
Highly Cited.
Human FOXP3+ T regulatory cell heterogeneity.
Audrey Mohr, Rajneesh Malhotra, +2 authors, Makoto Miyara.
Clin Transl Immunology, 2018 Feb 28; 7(1). PMID: 29484183    Free PMC article.
Highly Cited. Review.
Type 3 regulatory T cells at the interface of symbiosis.
Joo-Hong Park, Gérard Eberl.
J Microbiol, 2018 Mar 02; 56(3). PMID: 29492873
Review.
Immune Monitoring of Cancer Patients Prior to and During CTLA-4 or PD-1/PD-L1 Inhibitor Treatment.
Antje Tunger, Maximilian Kießler, +4 authors, Marc Schmitz.
Biomedicines, 2018 Mar 02; 6(1). PMID: 29494517    Free PMC article.
Review.
Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma.
Katarzyna C Pituch, Jason Miska, +8 authors, Irina V Balyasnikova.
Mol Ther, 2018 Mar 06; 26(4). PMID: 29503195    Free PMC article.
Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanisms to management.
Mark A Samaan, Polychronis Pavlidis, +2 authors, Peter M Irving.
Nat Rev Gastroenterol Hepatol, 2018 Mar 08; 15(4). PMID: 29512649
Review.
Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.
Mohamed B Ezzelarab, Lien Lu, +2 authors, Angus W Thomson.
Front Immunol, 2018 Mar 10; 9. PMID: 29520267    Free PMC article.
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew J S Furness, +32 authors, Sergio A Quezada.
Cancer Cell, 2018 Mar 27; 33(4). PMID: 29576375    Free PMC article.
Highly Cited.
Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Jessica R Ingram, Olga S Blomberg, +15 authors, Michael Dougan.
Proc Natl Acad Sci U S A, 2018 Mar 28; 115(15). PMID: 29581255    Free PMC article.
Highly Cited.
Gene Therapy With Regulatory T Cells: A Beneficial Alliance.
Moanaro Biswas, Sandeep R P Kumar, Cox Terhorst, Roland W Herzog.
Front Immunol, 2018 Apr 05; 9. PMID: 29616042    Free PMC article.
Review.
Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
Randi B Gombos, Ana Gonzalez, +24 authors, Nicholas S Wilson.
PLoS One, 2018 Apr 05; 13(4). PMID: 29617360    Free PMC article.
Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies.
Roberta Zappasodi, Taha Merghoub, Jedd D Wolchok.
Cancer Cell, 2018 Apr 11; 33(4). PMID: 29634946    Free PMC article.
Highly Cited. Review.
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.
Judith A Seidel, Atsushi Otsuka, Kenji Kabashima.
Front Oncol, 2018 Apr 13; 8. PMID: 29644214    Free PMC article.
Highly Cited. Review.
Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin.
Francesco Marangoni, Ruan Zhang, +8 authors, Thorsten R Mempel.
J Immunol, 2018 Apr 18; 200(10). PMID: 29661826    Free PMC article.
Functional Defects of Treg Cells: New Targets in Rheumatic Diseases, Including Ankylosing Spondylitis.
Jinlin Miao, Ping Zhu.
Curr Rheumatol Rep, 2018 Apr 18; 20(5). PMID: 29663162
Review.
Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma?
Sylvia C Kurz, Patrick Y Wen.
Curr Treat Options Neurol, 2018 Apr 19; 20(5). PMID: 29666934
Review.
Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation.
Hongyan Zhao, Ning Zhao, +5 authors, Dahong Ju.
J Immunol Res, 2018 Apr 21; 2018. PMID: 29675436    Free PMC article.
Review.
Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma.
Dai Kamamoto, Kentaro Ohara, +3 authors, Hikaru Sasaki.
J Neurooncol, 2018 Apr 21; 139(2). PMID: 29675794
Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation.
Jigesh A Shah, Miguel A Lanaspa, +3 authors, Kazuhiko Yamada.
J Immunol Res, 2018 Apr 25; 2018. PMID: 29687010    Free PMC article.
Review.
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?
Laura de Ramon, Jordi Guiteras, +3 authors, Juan Torras.
Int J Mol Sci, 2018 Apr 26; 19(5). PMID: 29693595    Free PMC article.
Review.
T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Claudia M Tellez Freitas, Deborah K Johnson, K Scott Weber.
Int J Mol Sci, 2018 Apr 28; 19(5). PMID: 29701673    Free PMC article.
Review.
Regulatory T Cells As Potential Targets for HIV Cure Research.
Adam J Kleinman, Ranjit Sivanandham, +2 authors, Cristian Apetrei.
Front Immunol, 2018 May 01; 9. PMID: 29706961    Free PMC article.
Review.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
Charlotte Schwab, Annemarie Gabrysch, +78 authors, Bodo Grimbacher.
J Allergy Clin Immunol, 2018 May 08; 142(6). PMID: 29729943    Free PMC article.
Highly Cited.
Very Low Numbers of CD4+ FoxP3+ Tregs Expanded in Donors via TL1A-Ig and Low-Dose IL-2 Exhibit a Distinct Activation/Functional Profile and Suppress GVHD in a Preclinical Model.
Sabrina Copsel, Dietlinde Wolf, +7 authors, Robert B Levy.
Biol Blood Marrow Transplant, 2018 May 12; 24(9). PMID: 29751114    Free PMC article.
Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases.
Stella Hartono, Michelina Rosa Ippoliti, +2 authors, Nicholas L Rider.
Clin Rev Allergy Immunol, 2018 May 14; 57(2). PMID: 29754192
Review.
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
Remy Thomas, Ghaneya Al-Khadairi, +4 authors, Julie Decock.
Front Immunol, 2018 May 18; 9. PMID: 29770138    Free PMC article.
Highly Cited. Review.
Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.
Pedro A C Costa, Maria M Figueiredo, +7 authors, Lis R V Antonelli.
J Infect Dis, 2018 May 26; 218(8). PMID: 29800313    Free PMC article.
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer.
Nicholas Borcherding, Ryan Kolb, +3 authors, Weizhou Zhang.
J Mol Biol, 2018 May 26; 430(14). PMID: 29800567    Free PMC article.
Review.
Immune checkpoint therapy in liver cancer.
Feng Xu, Tianqiang Jin, Yuwen Zhu, Chaoliu Dai.
J Exp Clin Cancer Res, 2018 May 31; 37(1). PMID: 29843754    Free PMC article.
Highly Cited. Review.
Type 1 Diabetes Mellitus: Cellular and Molecular Pathophysiology at A Glance.
Bahar Saberzadeh-Ardestani, Razieh Karamzadeh, +5 authors, Hossein Baharvand.
Cell J, 2018 May 31; 20(3). PMID: 29845781    Free PMC article.
The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway.
Xin-Ye Li, Liang Su, +7 authors, Wen-Bo Liang.
Evid Based Complement Alternat Med, 2018 Jun 01; 2018. PMID: 29849718    Free PMC article.
CNS cancer immunity cycle and strategies to target this for glioblastoma.
Malaka Ameratunga, Niamh Coleman, +2 authors, Juanita Lopez.
Oncotarget, 2018 Jun 02; 9(32). PMID: 29854316    Free PMC article.
Review.
Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens.
Mengjia Song, Xinfeng Chen, Liping Wang, Yi Zhang.
Chin J Cancer Res, 2018 Jun 05; 30(2). PMID: 29861603    Free PMC article.
Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
Maria J Forteza, Konstantinos A Polyzos, +6 authors, Daniel F J Ketelhuth.
Front Immunol, 2018 Jun 06; 9. PMID: 29867939    Free PMC article.
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.
Ethan M Shevach.
Front Immunol, 2018 Jun 06; 9. PMID: 29868011    Free PMC article.
Highly Cited. Review.
Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions.
Christian M Schürch.
Front Oncol, 2018 Jun 06; 8. PMID: 29868474    Free PMC article.
Review.
Emerging Functions of Regulatory T Cells in Tissue Homeostasis.
Amit Sharma, Dipayan Rudra.
Front Immunol, 2018 Jun 12; 9. PMID: 29887862    Free PMC article.
Highly Cited. Review.
Human αβ and γδ T Cells in Skin Immunity and Disease.
Michelle S Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson.
Front Immunol, 2018 Jun 22; 9. PMID: 29928283    Free PMC article.
Review.
Common Features of Regulatory T Cell Specialization During Th1 Responses.
Katharina Littringer, Claudia Moresi, +10 authors, Nicole Joller.
Front Immunol, 2018 Jun 29; 9. PMID: 29951069    Free PMC article.
Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future.
Mark A Perazella, Anushree C Shirali.
J Am Soc Nephrol, 2018 Jul 01; 29(8). PMID: 29959196    Free PMC article.
Highly Cited. Review.
Bladder Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer.
Skyler B Johnson, James B Yu.
Curr Oncol Rep, 2018 Jul 01; 20(9). PMID: 29959582
Review.
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma.
Janet Retseck, Alexis Nasr, +4 authors, Ahmad A Tarhini.
J Transl Med, 2018 Jul 06; 16(1). PMID: 29973204    Free PMC article.
CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function.
Yang Chen, Shu Chen, +13 authors, Tao Yang.
Sci Rep, 2018 Jul 06; 8(1). PMID: 29973665    Free PMC article.
CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse.
Rocky L Baker, Braxton L Jamison, +7 authors, Kathryn Haskins.
Diabetes, 2018 Jul 07; 67(9). PMID: 29976617    Free PMC article.
Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity.
Jiu-Cheng Zhang, Wei-Dong Chen, +6 authors, Hua Zhu.
Acta Pharmacol Sin, 2018 Jul 12; 39(11). PMID: 29991709    Free PMC article.
Review.
Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4.
Min Yang, Katrin Klocke, +4 authors, Rikard Holmdahl.
Immunology, 2018 Jul 12; 155(4). PMID: 29992549    Free PMC article.
Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases.
Yu Tai, Qingtong Wang, +2 authors, Wei Wei.
Front Pharmacol, 2018 Jul 13; 9. PMID: 29997500    Free PMC article.
Review.
Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells.
D Calzada, S Baos, L Cremades-Jimeno, B Cárdaba.
J Immunol Res, 2018 Jul 18; 2018. PMID: 30013991    Free PMC article.
Review.
CD226 opposes TIGIT to disrupt Tregs in melanoma.
Julien Fourcade, Zhaojun Sun, +11 authors, Hassane M Zarour.
JCI Insight, 2018 Jul 27; 3(14). PMID: 30046006    Free PMC article.
CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro.
Nina Pilat, Benedikt Mahr, +2 authors, Thomas Wekerle.
J Immunol Res, 2018 Jul 31; 2018. PMID: 30057914    Free PMC article.
Treg Fragility: A Prerequisite for Effective Antitumor Immunity?
Abigail E Overacre-Delgoffe, Dario A A Vignali.
Cancer Immunol Res, 2018 Aug 03; 6(8). PMID: 30068755    Free PMC article.
Review.
CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
Benjamin K Watkins, Victor Tkachev, +21 authors, Leslie S Kean.
J Clin Invest, 2018 Aug 14; 128(9). PMID: 30102255    Free PMC article.
Detection of Treg/Th17 cells and related cytokines in peripheral blood of chronic hepatitis B patients combined with thrombocytopenia and the clinical significance.
Yinghui Wang, Liru Wang, +2 authors, Yanhua Su.
Exp Ther Med, 2018 Aug 17; 16(2). PMID: 30112063    Free PMC article.
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors.
Yang Liu, Yinping Dong, +3 authors, Jinming Yu.
J Hematol Oncol, 2018 Aug 18; 11(1). PMID: 30115069    Free PMC article.
Highly Cited. Review.
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy.
Thibault Le Bourgeois, Laura Strauss, +4 authors, Vassiliki A Boussiotis.
Front Oncol, 2018 Aug 21; 8. PMID: 30123774    Free PMC article.
Highly Cited. Review.
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options.
Derya Kabacaoglu, Katrin J Ciecielski, Dietrich A Ruess, Hana Algül.
Front Immunol, 2018 Aug 31; 9. PMID: 30158932    Free PMC article.
Review.
Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology.
Lei Qin, Tayab C Waseem, +4 authors, Roza Nurieva.
Front Immunol, 2018 Aug 31; 9. PMID: 30158933    Free PMC article.
Review.
Regulation of human T cell responses by dNP2-ctCTLA-4 inhibits human skin and microvessel graft rejection.
Sangho Lim, Nancy C Kirkiles-Smith, +2 authors, Je-Min Choi.
Biomaterials, 2018 Aug 31; 183. PMID: 30165256    Free PMC article.
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.
Lee-Shing Chang, Romualdo Barroso-Sousa, +3 authors, Le Min.
Endocr Rev, 2018 Sep 06; 40(1). PMID: 30184160    Free PMC article.
Review.
Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells.
Juhee Kim, Jun Young Lee, +6 authors, Jae-Ho Cho.
Front Immunol, 2018 Sep 08; 9. PMID: 30190718    Free PMC article.
Immune checkpoint inhibitors for hepatocellular carcinoma.
Christopher E Jensen, Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes.
Hepat Oncol, 2016 Aug 01; 3(3). PMID: 30191042    Free PMC article.
Review.
Control of Germinal Center Responses by T-Follicular Regulatory Cells.
James B Wing, Murat Tekgüç, Shimon Sakaguchi.
Front Immunol, 2018 Sep 11; 9. PMID: 30197643    Free PMC article.
Review.
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
Andreas Jeron, Julia D Boehme, +7 authors, Dunja Bruder.
Int J Mol Sci, 2018 Sep 12; 19(9). PMID: 30200513    Free PMC article.
New strategies in immunotherapy for lung cancer: beyond PD-1/PD-L1.
Nicolas Villanueva, Lyudmila Bazhenova.
Ther Adv Respir Dis, 2018 Sep 15; 12. PMID: 30215300    Free PMC article.
Review.
Characterization of CTLA4 Trafficking and Implications for Its Function.
Sahamoddin Khailaie, Behzad Rowshanravan, +6 authors, Michael Meyer-Hermann.
Biophys J, 2018 Sep 17; 115(7). PMID: 30219287    Free PMC article.
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia.
Marina Wierz, Bassam Janji, +2 authors, Jerome Paggetti.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221064    Free PMC article.
Combination immune checkpoint blockade as an effective therapy for mesothelioma.
Vanessa S Fear, Caitlin Tilsed, +10 authors, Scott A Fisher.
Oncoimmunology, 2018 Oct 06; 7(10). PMID: 30288361    Free PMC article.
Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T cells.
Alejandra Marinelarena, Palash Bhattacharya, +2 authors, Bellur S Prabhakar.
Sci Rep, 2018 Oct 10; 8(1). PMID: 30297856    Free PMC article.
Regulatory T cells in the treatment of disease.
Amir Sharabi, Maria G Tsokos, +3 authors, George C Tsokos.
Nat Rev Drug Discov, 2018 Oct 13; 17(11). PMID: 30310234
Highly Cited. Review.
Role of the immunosuppressive microenvironment in immunotherapy.
Garth W Tormoen, Marka R Crittenden, Michael J Gough.
Adv Radiat Oncol, 2018 Oct 30; 3(4). PMID: 30370351    Free PMC article.
Review.
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.
Tomokazu Sumida, Matthew R Lincoln, +7 authors, David A Hafler.
Nat Immunol, 2018 Oct 31; 19(12). PMID: 30374130    Free PMC article.
Regulatory T Cells in Systemic Sclerosis.
Camelia Frantz, Cedric Auffray, Jerome Avouac, Yannick Allanore.
Front Immunol, 2018 Oct 31; 9. PMID: 30374354    Free PMC article.
Review.
Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.
Samantha L Bucktrout, Jeffrey A Bluestone, Fred Ramsdell.
Genome Med, 2018 Nov 01; 10(1). PMID: 30376867    Free PMC article.
Review.
Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency.
Leisa Rebecca Watson, Charlotte A Slade, +9 authors, Michael Sze Yuan Low.
Allergy Asthma Clin Immunol, 2018 Nov 01; 14. PMID: 30377434    Free PMC article.
The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.
Nada Abdel Aziz, Justin Komguep Nono, Thabo Mpotje, Frank Brombacher.
PLoS Biol, 2018 Nov 01; 16(10). PMID: 30379806    Free PMC article.
Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses.
Christophe Pedros, Amnon Altman, Kok-Fai Kong.
Front Immunol, 2018 Nov 09; 9. PMID: 30405612    Free PMC article.
Review.
Regulation of the Germinal Center Response.
Marisa Stebegg, Saumya D Kumar, +3 authors, Luis Graca.
Front Immunol, 2018 Nov 10; 9. PMID: 30410492    Free PMC article.
Review.
Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny.
Mark R Dowling, Andrey Kan, +3 authors, Edwin D Hawkins.
Front Immunol, 2018 Nov 15; 9. PMID: 30425712    Free PMC article.
Control of the Germinal Center by Follicular Regulatory T Cells During Infection.
Brodie Miles, Elizabeth Connick.
Front Immunol, 2018 Dec 14; 9. PMID: 30524440    Free PMC article.
Review.
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy.
Monika C Brunner-Weinzierl, Christopher E Rudd.
Front Immunol, 2018 Dec 14; 9. PMID: 30542345    Free PMC article.
Review.
Response of regulatory T cells to classic heat stroke in mice.
Jie Hu, Hong-Jun Kang, +3 authors, Fei-Hu Zhou.
Exp Ther Med, 2018 Dec 14; 16(6). PMID: 30542411    Free PMC article.
Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood.
Magdalena Niedzielska, Elisabeth Israelsson, +5 authors, Céline Dumont.
Oncotarget, 2018 Dec 14; 9(90). PMID: 30546835    Free PMC article.
Targeting Type 1 Diabetes: Selective Approaches for New Therapies.
Daniel F Sheehy, Sean P Quinnell, Arturo J Vegas.
Biochemistry, 2019 Jan 05; 58(4). PMID: 30608114    Free PMC article.
Review.
Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg-mediated suppression of cytokine expression.
Rubin N Joshi, Sunjay Jude Fernandes, +4 authors, Angelika Schmidt.
J Leukoc Biol, 2019 Mar 19; 106(2). PMID: 30882958    Free PMC article.
Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.
Tomoyuki Yamaguchi, Shunsuke Teraguchi, +5 authors, Toshio Yanagida.
Int Immunol, 2019 May 28; 31(11). PMID: 31131864    Free PMC article.
pH-sensitive anti-CTLA4 antibodies: yes to efficacy, no to toxicity.
Amnon Altman, Kok-Fai Kong.
Cell Res, 2019 Jul 14; 29(8). PMID: 31300731    Free PMC article.
Radiation as an In Situ Auto-Vaccination: Current Perspectives and Challenges.
Taichiro Goto.
Vaccines (Basel), 2019 Aug 29; 7(3). PMID: 31455032    Free PMC article.
Review.
Challenges and Opportunities for Childhood Cancer Drug Development.
Peter J Houghton, Raushan T Kurmasheva.
Pharmacol Rev, 2019 Sep 29; 71(4). PMID: 31558580    Free PMC article.
Review.
Immune Checkpoints as Promising Targets for the Treatment of Idiopathic Pulmonary Fibrosis?
JanWillem Duitman, Tom van den Ende, C Arnold Spek.
J Clin Med, 2019 Sep 29; 8(10). PMID: 31561518    Free PMC article.
Review.
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Martina Di Giovangiulio, Angelamaria Rizzo, +8 authors, Massimo C Fantini.
Front Immunol, 2019 Oct 02; 10. PMID: 31572375    Free PMC article.
Current Perspectives in Cancer Immunotherapy.
Theodoulakis Christofi, Stavroula Baritaki, +2 authors, Apostolos Zaravinos.
Cancers (Basel), 2019 Oct 03; 11(10). PMID: 31575023    Free PMC article.
Review.
Immuno-Oncology Therapy for Hepatocellular Carcinoma: Current Status and Ongoing Trials.
Masatoshi Kudo.
Liver Cancer, 2019 Oct 12; 8(4). PMID: 31602367    Free PMC article.
Immunobiology of Atherosclerosis: A Complex Net of Interactions.
Beatriz Herrero-Fernandez, Raquel Gomez-Bris, Beatriz Somovilla-Crespo, Jose Maria Gonzalez-Granado.
Int J Mol Sci, 2019 Oct 28; 20(21). PMID: 31653058    Free PMC article.
Review.
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story.
Geny Piro, Carmine Carbone, +6 authors, Giampaolo Tortora.
Cancers (Basel), 2019 Oct 30; 11(10). PMID: 31658667    Free PMC article.
Review.
Translational Approaches Targeting Ceramide Generation From Sphingomyelin in T Cells to Modulate Immunity in Humans.
Claudia Hollmann, Teresa Wiese, +3 authors, Niklas Beyersdorf.
Front Immunol, 2019 Nov 05; 10. PMID: 31681273    Free PMC article.
Review.
IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors.
Ju Chen, Xiaoyang Ye, +6 authors, Kepeng Wang.
J Immunother Cancer, 2019 Nov 30; 7(1). PMID: 31775909    Free PMC article.
Regulatory T cell modulation of cytokine and cellular networks in corneal graft rejection.
Maryam Tahvildari, Takenori Inomata, Afsaneh Amouzegar, Reza Dana.
Curr Ophthalmol Rep, 2019 Dec 07; 6(4). PMID: 31807370    Free PMC article.
Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function.
Hye Ryun Kim, Hyo Jin Park, +13 authors, Sang-Jun Ha.
J Immunother Cancer, 2019 Dec 06; 7(1). PMID: 31801611    Free PMC article.
Setting the scene - a future 'epidemic' of immune-related adverse events in association with checkpoint inhibitor therapy.
Maria V Bermudez, Sophie Papa.
Rheumatology (Oxford), 2019 Dec 10; 58(Suppl 7). PMID: 31816083    Free PMC article.
Review.
STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer.
Ayman J Oweida, Laurel Darragh, +11 authors, Sana D Karam.
J Natl Cancer Inst, 2019 Mar 14; 111(12). PMID: 30863843    Free PMC article.
Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function.
Sung Woong Jang, Soo Seok Hwang, +7 authors, Gap Ryol Lee.
Proc Natl Acad Sci U S A, 2019 Dec 04; 116(51). PMID: 31792183    Free PMC article.
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer.
Katsiaryna Marhelava, Zofia Pilch, +2 authors, Radoslaw Zagozdzon.
Cancers (Basel), 2019 Nov 14; 11(11). PMID: 31717326    Free PMC article.
Review.
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Yunlong Zhao, Calvin K Lee, +8 authors, Enfu Hui.
Immunity, 2019 Nov 24; 51(6). PMID: 31757674    Free PMC article.
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
Yan Zhang, Xuexiang Du, +9 authors, Yang Liu.
Cell Res, 2019 Jul 04; 29(8). PMID: 31267017    Free PMC article.
T-Regulatory Cells In Tumor Progression And Therapy.
Amit Verma, Rohit Mathur, +3 authors, Bilikere S Dwarakanath.
Cancer Manag Res, 2020 Jan 11; 11. PMID: 31920383    Free PMC article.
Review.
CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation.
Antonella Mancusi, Sara Piccinelli, Andrea Velardi, Antonio Pierini.
Front Immunol, 2020 Jan 11; 10. PMID: 31921162    Free PMC article.
Review.
Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients.
Salman M Toor, Khaled Murshed, +3 authors, Eyad Elkord.
Front Immunol, 2020 Jan 11; 10. PMID: 31921188    Free PMC article.
Impact of infection on transplantation tolerance.
Shuangjin Yu, Chang Su, Xunrong Luo.
Immunol Rev, 2019 Sep 21; 292(1). PMID: 31538351    Free PMC article.
Review.
Reduced GLP-1 response to a meal is associated with the CTLA4 rs3087243 G/G genotype.
András Zóka, Gábor Barna, +5 authors, Gábor Firneisz.
Cent Eur J Immunol, 2020 Jan 15; 44(3). PMID: 31933538    Free PMC article.
Anti-Leishmanial Vaccines: Assumptions, Approaches, and Annulments.
Shubhranshu Zutshi, Sunil Kumar, +5 authors, Bhaskar Saha.
Vaccines (Basel), 2019 Oct 23; 7(4). PMID: 31635276    Free PMC article.
Review.
Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Tijana Martinov, Brian T Fife.
Ann N Y Acad Sci, 2019 Apr 27; 1461(1). PMID: 31025378    Free PMC article.
Review.
IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors.
Jonathan H DeLong, Aisling O'Hara Hall, +8 authors, Christopher A Hunter.
Immunohorizons, 2019 Jul 30; 3(1). PMID: 31356173    Free PMC article.
Costimulation Blockade in Kidney Transplant Recipients.
Marieke van der Zwan, Dennis A Hesselink, Martijn W F van den Hoogen, Carla C Baan.
Drugs, 2019 Nov 22; 80(1). PMID: 31749062    Free PMC article.
Review.
Reverting Immune Suppression to Enhance Cancer Immunotherapy.
Bella S Guerrouahen, Cristina Maccalli, +2 authors, Emmanuel T Akporiaye.
Front Oncol, 2020 Feb 11; 9. PMID: 32039024    Free PMC article.
Review.
PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.
Johanna A Knipper, David Wright, +2 authors, Rose Zamoyska.
Front Immunol, 2020 Feb 13; 11. PMID: 32047502    Free PMC article.
CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.
Ning Wang, Shuang Liang, +5 authors, Lihua Chen.
Immunol Res, 2020 Jan 11; 67(6). PMID: 31919790
Regulatory T Cells for More Targeted Immunosuppressive Therapies.
Hazim Allos, Basmah S Al Dulaijan, John Choi, Jamil Azzi.
Clin Lab Med, 2019 Feb 03; 39(1). PMID: 30709499    Free PMC article.
Review.
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.
Bi-Huei Yang, Ke Wang, +10 authors, Wenxian Fu.
Cell Rep, 2019 Jun 20; 27(12). PMID: 31216480    Free PMC article.
NLRC5: new cancer buster?
Feng Tang, Yadi Xu, Bing Zhao.
Mol Biol Rep, 2020 Jan 12; 47(3). PMID: 31925644
Review.
Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response.
Qingyang Xiao, André Nobre, +5 authors, Isabel Barragán.
J Clin Med, 2020 Jan 24; 9(1). PMID: 31968651    Free PMC article.
Review.
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.
Sara Saab, Hussein Zalzale, +3 authors, Humam Kadara.
Front Immunol, 2020 Mar 03; 11. PMID: 32117295    Free PMC article.
Review.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.
Takahiro Kamada, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa.
Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147    Free PMC article.
Highly Cited.
Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens.
Andreia S Da Costa, Jessica B Graham, Jessica L Swarts, Jennifer M Lund.
Proc Natl Acad Sci U S A, 2019 May 01; 116(20). PMID: 31036644    Free PMC article.
Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance.
Radhika R Gudi, Subha Karumuthil-Melethil, +2 authors, Chenthamarakshan Vasu.
Sci Rep, 2019 Aug 21; 9(1). PMID: 31427630    Free PMC article.
T lymphocyte-targeted immune checkpoint modulation in glioma.
William James Kelly, Amber Jin Giles, Mark Gilbert.
J Immunother Cancer, 2020 Feb 14; 8(1). PMID: 32051289    Free PMC article.
Review.
CTLA-4: a moving target in immunotherapy.
Behzad Rowshanravan, Neil Halliday, David M Sansom.
Blood, 2017 Nov 10; 131(1). PMID: 29118008    Free PMC article.
Highly Cited. Review.
Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Xiaolei Li, Changshun Shao, Yufang Shi, Weidong Han.
J Hematol Oncol, 2018 Feb 28; 11(1). PMID: 29482595    Free PMC article.
Highly Cited. Review.
Clinical Relevance of the serum CTLA-4 in Cats with Mammary Carcinoma.
Ana Catarina Urbano, Catarina Nascimento, +2 authors, Fernando Ferreira.
Sci Rep, 2020 Mar 04; 10(1). PMID: 32123292    Free PMC article.
CAR T cells for infection, autoimmunity and allotransplantation.
Colby R Maldini, Gavin I Ellis, James L Riley.
Nat Rev Immunol, 2018 Jul 27; 18(10). PMID: 30046149    Free PMC article.
Highly Cited. Review.
Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers.
Anu Sharma, Sumit K Subudhi, +6 authors, Padmanee Sharma.
Clin Cancer Res, 2018 Jul 29; 25(4). PMID: 30054281    Free PMC article.
Highly Cited.
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid.
C Álvarez-Larrotta, O M Agudelo, +5 authors, E Arango.
Clin Exp Immunol, 2018 Sep 09; 195(1). PMID: 30194852    Free PMC article.
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Abdul Malik Tyagi, Mingcan Yu, +8 authors, Roberto Pacifici.
Immunity, 2018 Nov 18; 49(6). PMID: 30446387    Free PMC article.
Highly Cited.
Human CD8+HLA-DR+ Regulatory T Cells, Similarly to Classical CD4+Foxp3+ Cells, Suppress Immune Responses via PD-1/PD-L1 Axis.
Andres Machicote, Santiago Belén, +2 authors, Leonardo Fainboim.
Front Immunol, 2018 Dec 18; 9. PMID: 30555473    Free PMC article.
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody.
Danbee Ha, Atsushi Tanaka, +10 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2018 Dec 28; 116(2). PMID: 30587582    Free PMC article.
Unregulated antigen-presenting cell activation by T cells breaks self tolerance.
Jaeu Yi, Jisun Jung, +5 authors, Charles D Surh.
Proc Natl Acad Sci U S A, 2019 Jan 02; 116(3). PMID: 30598454    Free PMC article.
Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer.
Franziska Eckert, Karin Schilbach, +5 authors, Stephan M Huber.
Front Immunol, 2019 Jan 10; 9. PMID: 30622535    Free PMC article.
Review.
Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3.
Ashley E Landuyt, Barbara J Klocke, +2 authors, Craig L Maynard.
J Immunol, 2019 Jan 16; 202(4). PMID: 30642977    Free PMC article.
Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.
Billur Akkaya, Yoshihiro Oya, +8 authors, Ethan M Shevach.
Nat Immunol, 2019 Jan 16; 20(2). PMID: 30643268    Free PMC article.
Highly Cited.
The eye as a novel imaging site in diabetes research.
Shao-Nian Yang, Per-Olof Berggren.
Pharmacol Ther, 2019 Jan 25; 197. PMID: 30677477    Free PMC article.
Review.
TLR4 signaling improves PD-1 blockade therapy during chronic viral infection.
Yidan Wang, Young Rock Chung, +4 authors, Pablo Penaloza-MacMaster.
PLoS Pathog, 2019 Feb 07; 15(2). PMID: 30726291    Free PMC article.
α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma.
Qianhui Chen, Xuxue Guo, +9 authors, Hanxiang Nie.
J Biol Chem, 2019 Feb 13; 294(14). PMID: 30745361    Free PMC article.
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Garima Garg, Andreas Muschaweckh, +19 authors, Thomas Korn.
Cell Rep, 2019 Feb 14; 26(7). PMID: 30759395    Free PMC article.
Highly Cited.
IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.
Quan Liu, Gaelen K Dwyer, +13 authors, Hēth R Turnquist.
JCI Insight, 2019 Feb 20; 4(6). PMID: 30779711    Free PMC article.
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.
Jessica Bourque, Daniel Hawiger.
Crit Rev Immunol, 2019 Feb 23; 38(5). PMID: 30792568    Free PMC article.
Highly Cited. Review.
Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.
Julia Roider, Abigail Ngoepe, +6 authors, Alasdair Leslie.
Front Immunol, 2019 Feb 28; 10. PMID: 30809229    Free PMC article.
Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework.
Oskar A Haas.
Front Immunol, 2019 Feb 28; 9. PMID: 30809233    Free PMC article.
Review.
Immunotherapy: Current Status and Future Perspectives.
Charalampos S Floudas, Gagandeep Brar, Tim F Greten.
Dig Dis Sci, 2019 Mar 05; 64(4). PMID: 30830521
Review.
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
Marcin Łyszkiewicz, Samantha J Winter, +19 authors, Andreas Krueger.
PLoS Biol, 2019 Mar 12; 17(3). PMID: 30856173    Free PMC article.
Immune targets in the tumor microenvironment treated by radiotherapy.
Omer M Ozpiskin, Lu Zhang, Jian Jian Li.
Theranostics, 2019 Mar 15; 9(5). PMID: 30867826    Free PMC article.
Highly Cited. Review.
Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells.
Priscilla Do, Kyle A Beckwith, +9 authors, John C Byrd.
J Immunol, 2019 Mar 27; 202(9). PMID: 30910862    Free PMC article.
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Spencer C Wei, Roshan Sharma, +8 authors, James P Allison.
Immunity, 2019 Mar 31; 50(4). PMID: 30926234    Free PMC article.
Treg cells in autoimmunity: from identification to Treg-based therapies.
Lisa Göschl, Clemens Scheinecker, Michael Bonelli.
Semin Immunopathol, 2019 Apr 07; 41(3). PMID: 30953162
Review.
Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function.
Jiazi Ren, Lei Han, +8 authors, Haikun Wang.
PLoS Biol, 2019 May 28; 17(5). PMID: 31125332    Free PMC article.
Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Marc Rosenbaum, Andreas Gewies, +11 authors, Jürgen Ruland.
Nat Commun, 2019 May 30; 10(1). PMID: 31138793    Free PMC article.
CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells.
Vitalijs Ovcinnikovs, Ellen M Ross, +9 authors, Lucy S K Walker.
Sci Immunol, 2019 Jun 04; 4(35). PMID: 31152091    Free PMC article.
Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells.
Theodore T Drashansky, Eric Helm, +12 authors, Dorina Avram.
Sci Adv, 2019 Aug 29; 5(8). PMID: 31457080    Free PMC article.
Bcl11b prevents catastrophic autoimmunity by controlling multiple aspects of a regulatory T cell gene expression program.
Syed Nurul Hasan, Amit Sharma, +5 authors, Dipayan Rudra.
Sci Adv, 2019 Aug 29; 5(8). PMID: 31457081    Free PMC article.
Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy.
Anna Galstyan, Janet L Markman, +18 authors, Julia Y Ljubimova.
Nat Commun, 2019 Aug 30; 10(1). PMID: 31462642    Free PMC article.
Highly Cited.
Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research.
Shinji Maeda, Satoshi Osaga, +4 authors, Akio Niimi.
PLoS One, 2019 Nov 21; 14(11). PMID: 31747403    Free PMC article.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Kei Kunimasa, Taichiro Goto.
Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413    Free PMC article.
Review.
Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy.
Wenhua Xu, Mingshan Ren, +5 authors, Jiajun Cui.
Mediators Inflamm, 2020 Mar 10; 2020. PMID: 32148437    Free PMC article.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy.
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The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases.
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Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy.
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Front Immunol, 2020 Mar 21; 11. PMID: 32194568    Free PMC article.
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Down-regulated Treg cells in exacerbated periodontal disease during pregnancy.
Aislinn Hays, Xingyu Duan, +8 authors, Shuang Liang.
Int Immunopharmacol, 2019 Feb 13; 69. PMID: 30753969    Free PMC article.
Foxp3⁺ T(reg) cells in humoral immunity.
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Immunosuppressive mechanisms during viral infectious diseases.
Ghanashyam Sarikonda, Matthias G von Herrath.
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The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.
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CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes.
Moritz Rapp, Maximilian W M Wintergerst, +18 authors, David Anz.
J Exp Med, 2019 Mar 27; 216(5). PMID: 30910796    Free PMC article.
Development of immune checkpoint therapy for cancer.
Jill M Fritz, Michael J Lenardo.
J Exp Med, 2019 May 10; 216(6). PMID: 31068379    Free PMC article.
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FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy.
Xin Chen, Xiaomin Song, Kang Li, Tong Zhang.
Front Immunol, 2019 Mar 14; 10. PMID: 30863404    Free PMC article.
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The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells.
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The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer.
Nanna Jørgensen, Gry Persson, Thomas Vauvert F Hviid.
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Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma.
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Front Immunol, 2019 May 28; 10. PMID: 31134073    Free PMC article.
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MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.
Annelies Demeyer, Ioannis Skordos, +5 authors, Rudi Beyaert.
Front Immunol, 2019 Sep 03; 10. PMID: 31474984    Free PMC article.
Role of Regulatory Immune Cells and Molecules in Autoimmune Bullous Dermatoses.
Tianyu Cao, Shuai Shao, +2 authors, Gang Wang.
Front Immunol, 2019 Aug 21; 10. PMID: 31428090    Free PMC article.
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JunB Controls Intestinal Effector Programs in Regulatory T Cells.
Joshua D Wheaton, Maria Ciofani.
Front Immunol, 2020 Apr 17; 11. PMID: 32296416    Free PMC article.
Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease.
Elisa Martini, Silvia Giugliano, Maria Rescigno, Marinos Kallikourdis.
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Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help.
Eleni Maria Varypataki, Fabio Hasler, +6 authors, Pål Johansen.
Front Immunol, 2019 Jul 25; 10. PMID: 31333674    Free PMC article.
Mechanisms of checkpoint inhibition-induced adverse events.
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Bee Venom Phospholipase A2 Induces Regulatory T Cell Populations by Suppressing Apoptotic Signaling Pathway.
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Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells.
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T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
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Solid Tumors Challenges and New Insights of CAR T Cell Engineering.
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Stem Cell Rev Rep, 2019 Jun 05; 15(5). PMID: 31161552
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IL36 Cooperates With Anti-CTLA-4 mAbs to Facilitate Antitumor Immune Responses.
Qiuxia Qu, Zhiwei Zhai, +3 authors, Binfeng Lu.
Front Immunol, 2020 May 01; 11. PMID: 32351508    Free PMC article.
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy.
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Regulatory T Cells: the Many Faces of Foxp3.
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Preserving the CTLA-4 Checkpoint for Safer and More Effective Cancer Immunotherapy.
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Changing paradigms for targeted therapies against diffuse infiltrative gliomas: tackling a moving target.
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Expert Rev Neurother, 2019 May 21; 19(7). PMID: 31106606    Free PMC article.
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TGFβ1 mimetic peptide modulates immune response to grass pollen allergens in mice.
Galber R Araujo, Lorenz Aglas, +6 authors, Fatima Ferreira.
Allergy, 2019 Nov 22; 75(4). PMID: 31750952    Free PMC article.
Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities.
Kristen E Pauken, Michael Dougan, +2 authors, Arlene H Sharpe.
Trends Immunol, 2019 May 06; 40(6). PMID: 31053497    Free PMC article.
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Regulatory T-cell therapy in Crohn's disease: challenges and advances.
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An Integrative Network Modeling Approach to T CD4 Cell Activation.
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Front Physiol, 2020 May 20; 11. PMID: 32425809    Free PMC article.
A guide to cancer immunotherapy: from T cell basic science to clinical practice.
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Normalization Cancer Immunotherapy for Melanoma.
Matthew D Vesely, Lieping Chen.
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IRF4 instructs effector Treg differentiation and immune suppression in human cancer.
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Facing SARS-CoV-2 outbreak in immunotherapy era.
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Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis.
Yiding Li, Zhiming Wang, +16 authors, Lifan Xu.
Front Immunol, 2020 Jun 02; 11. PMID: 32477338    Free PMC article.
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.
Ciara N Magee, Naoka Murakami, +15 authors, Leonardo V Riella.
Circulation, 2019 Jul 04; 140(10). PMID: 31266349    Free PMC article.
A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.
Zachary T Freeman, Thomas R Nirschl, +17 authors, Charles G Drake.
J Clin Invest, 2020 Feb 06; 130(3). PMID: 32015231    Free PMC article.
Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints.
Kristian M Hargadon.
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Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
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Proc Natl Acad Sci U S A, 2020 May 18; 117(22). PMID: 32414925    Free PMC article.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
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Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding on Mechanisms of Resistance and Biomarkers of Response to Treatment.
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Gene Expr, 2020 Apr 29; 20(1). PMID: 32340652    Free PMC article.
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The efficacy and safety of combined immune checkpoint inhibitors (nivolumab plus ipilimumab): a systematic review and meta-analysis.
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Andrea Cossarizza, Hyun-Dong Chang, +433 authors, Arturo Zychlinsky.
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Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases.
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Directed differentiation of regulatory T cells from naive T cells and prevention of their inflammation-mediated instability using small molecules.
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CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells.
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Commun Biol, 2020 Jul 16; 3(1). PMID: 32665635    Free PMC article.
Protein Kinase C-η Deficiency Does Not Impair Antiviral Immunity and CD8+ T Cell Activation.
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J Immunol, 2020 Mar 22; 204(9). PMID: 32198145    Free PMC article.
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.
Michael A Gillette, Shankha Satpathy, +66 authors, Clinical Proteomic Tumor Analysis Consortium.
Cell, 2020 Jul 11; 182(1). PMID: 32649874    Free PMC article.
Immunological Basis of Genesis of Hepatocellular Carcinoma: Unique Challenges and Potential Opportunities through Immunomodulation.
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Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy.
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Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors.
Diwakar Davar, Hassane M Zarour.
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Regulatory Role of Immune Cell-Derived Extracellular Vesicles in Cancer: The Message Is in the Envelope.
Chi Li, Howard Donninger, John Eaton, Kavitha Yaddanapudi.
Front Immunol, 2020 Aug 09; 11. PMID: 32765528    Free PMC article.
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Targeting immune checkpoints in hematological malignancies.
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Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.
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PLoS One, 2020 Aug 14; 15(8). PMID: 32785290    Free PMC article.
Relevance of Regulatory T Cells during Colorectal Cancer Development.
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Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
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Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.
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Blood Adv, 2020 Aug 21; 4(16). PMID: 32818226    Free PMC article.
Exosome: A New Player in Translational Nanomedicine.
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Combinatorial approach to cancer immunotherapy: strength in numbers.
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The clinical promise of immunotherapy in triple-negative breast cancer.
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The Therapeutic Strategies of Regulatory T Cells in Malignancies and Stem Cell Transplantations.
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Heart failure in cancer: role of checkpoint inhibitors.
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Combination Cancer Immunotherapy with Molecular Targeted Agents/Anti-CTLA-4 Antibody for Hepatocellular Carcinoma.
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Liver Cancer, 2019 Mar 01; 8(1). PMID: 30815391    Free PMC article.
Pediatric Patients With Steroid-Sensitive Nephrotic Syndrome Have Higher Expression of T Regulatory Lymphocytes in Comparison to Steroid-Resistant Disease.
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Turning the Tide Against Regulatory T Cells.
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Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy.
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Cancers (Basel), 2019 May 08; 11(5). PMID: 31060225    Free PMC article.
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Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations.
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AP-1 Transcription Factors as Regulators of Immune Responses in Cancer.
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Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives.
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The evolving immuno-oncology landscape in advanced lung cancer: first-line treatment of non-small cell lung cancer.
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Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.
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Revisiting the PD-1 pathway.
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ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases.
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Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.
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Nat Immunol, 2019 Jan 16; 20(2). PMID: 30643266    Free PMC article.
Highly Cited.
Tolerance in the Age of Immunotherapy.
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Understanding and Overcoming the Inflammatory Toxicities of Immunotherapy.
Michael Dougan.
Cancer Immunol Res, 2020 Oct 03; 8(10). PMID: 33004412    Free PMC article.
The Role of MicroRNAs in Development and Function of Regulatory T Cells - Lessons for a Better Understanding of MicroRNA Biology.
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Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf.
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Sarcomatoid renal cell carcinoma: biology, natural history and management.
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Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade.
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PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
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Transcriptional regulation of Treg homeostasis and functional specification.
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IL-4Rα signaling in CD4+CD25+FoxP3+ T regulatory cells restrains airway inflammation via limiting local tissue IL-33.
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Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity.
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The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?
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Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism.
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Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
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Systematic Review.
Immunotherapy in Hematologic Malignancies: Emerging Therapies and Novel Approaches.
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Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?
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CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade.
Justin M Drerup, Yilun Deng, +11 authors, Tyler J Curiel.
Cancer Res, 2020 Sep 20; 80(22). PMID: 32948605    Free PMC article.
Combinational immunotherapy based on immune checkpoints inhibitors in small cell lung cancer: is this the beginning to reverse the refractory situation?
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Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
S C Sasson, J J Zaunders, +17 authors, A D Kelleher.
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Recent Advances on Rare Earth Upconversion Nanomaterials for Combined Tumor Near-Infrared Photoimmunotherapy.
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Regulatory T Cells: From Discovery to Autoimmunity.
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TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.
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A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates.
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Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study.
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Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
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How Does an Anti-CTLA-4 Antibody Promote Cancer Immunity?
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Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium.
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Medicine (Baltimore), 2019 Apr 16; 98(15). PMID: 30985663    Free PMC article.
PM2.5 affects establishment of immune tolerance in newborn mice by reducing PD-L1 expression.
L I Yan, Caihui Gong, +4 authors, Zhou Fu.
J Biosci, 2019 Jun 11; 44(2). PMID: 31180054
Combination of CTLA-4 and PD-1 blockers for treatment of cancer.
Anand Rotte.
J Exp Clin Cancer Res, 2019 Jun 15; 38(1). PMID: 31196207    Free PMC article.
Highly Cited. Review.
Immunotherapy for hepatocellular carcinoma: Current and future.
Michael P Johnston, Salim I Khakoo.
World J Gastroenterol, 2019 Jul 12; 25(24). PMID: 31293335    Free PMC article.
Review.
Haploidentical mixed chimerism cures autoimmunity in established type 1 diabetic mice.
Yuqing Liu, Xiaoqi Wang, +7 authors, Defu Zeng.
J Clin Invest, 2020 Aug 21; 130(12). PMID: 32817590    Free PMC article.
Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma.
Mohamed A Abd El Aziz, Antonio Facciorusso, +4 authors, Rodolfo Sacco.
Vaccines (Basel), 2020 Oct 23; 8(4). PMID: 33086471    Free PMC article.
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CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells.
Yini Sun, Jianfeng Xie, +7 authors, Mandy L Ford.
J Immunol, 2020 Nov 08; 205(12). PMID: 33158954    Free PMC article.
Host Response to Coccidioides Infection: Fungal Immunity.
Anh L Diep, Katrina K Hoyer.
Front Cell Infect Microbiol, 2020 Dec 03; 10. PMID: 33262956    Free PMC article.
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Activating the Antitumor Immune Response in Non-Hodgkin Lymphoma Using Immune Checkpoint Inhibitors.
Maansi Joshi, Stephen M Ansell.
J Immunol Res, 2020 Dec 10; 2020. PMID: 33294467    Free PMC article.
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Targeting co-stimulatory molecules in autoimmune disease.
Natalie M Edner, Gianluca Carlesso, James S Rush, Lucy S K Walker.
Nat Rev Drug Discov, 2020 Sep 18; 19(12). PMID: 32939077
Review.
The role of the programmed cell death protein-1/programmed death-ligand 1 pathway, regulatory T cells and T helper 17 cells in tumor immunity: a narrative review.
Lanfang Zhang, Mingjuan Zhang, +6 authors, Meiling Gu.
Ann Transl Med, 2020 Dec 15; 8(22). PMID: 33313271    Free PMC article.
Review.
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer.
Eva Pastille, Marie-Hélène Wasmer, +14 authors, Philippe Krebs.
Mucosal Immunol, 2019 Jun 06; 12(4). PMID: 31165767    Free PMC article.
Highly Cited.
MIF-Dependent Control of Tumor Immunity.
Jordan T Noe, Robert A Mitchell.
Front Immunol, 2020 Dec 17; 11. PMID: 33324425    Free PMC article.
Review.
Inhibitory receptor agonists: the future of autoimmune disease therapeutics?
Stephanie Grebinoski, Dario Aa Vignali.
Curr Opin Immunol, 2020 Jul 04; 67. PMID: 32619929    Free PMC article.
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Cutaneous plaque in adult T cell leukemia/lymphoma: A case report.
Chen Shuang Lei, Qian Jiang, Qinhua Yu, Liannv Qiu.
Medicine (Baltimore), 2020 Dec 18; 99(50). PMID: 33327284    Free PMC article.
Epstein-Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity.
Keiko Nagata, Kazuhiko Hayashi.
Microorganisms, 2020 Dec 03; 8(12). PMID: 33260824    Free PMC article.
Review.
Erythroid Differentiation Regulator 1 Ameliorates Collagen-Induced Arthritis via Activation of Regulatory T Cells.
Myun Soo Kim, Sora Lee, +3 authors, Daeho Cho.
Int J Mol Sci, 2020 Dec 19; 21(24). PMID: 33334006    Free PMC article.
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule.
Alexey Berezhnoy, Bradley J Sumrow, +16 authors, Paul A Moore.
Cell Rep Med, 2020 Dec 31; 1(9). PMID: 33377134    Free PMC article.
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease.
Andrea Kristina Horst, Kingsley Gideon Kumashie, +2 authors, Gisa Tiegs.
Cell Mol Immunol, 2020 Oct 29; 18(1). PMID: 33110250    Free PMC article.
Review.
Beyond T-Cells: Functional Characterization of CTLA-4 Expression in Immune and Non-Immune Cell Types.
Damilola Oyewole-Said, Vanaja Konduri, +3 authors, William K Decker.
Front Immunol, 2021 Jan 02; 11. PMID: 33384695    Free PMC article.
Review.
CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections.
Anna Estrada Brull, Felix Rost, +4 authors, Nicole Joller.
Int J Mol Sci, 2020 Dec 31; 22(1). PMID: 33375121    Free PMC article.
Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy.
Christopher Tay, Yamin Qian, Shimon Sakaguchi.
Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33375291    Free PMC article.
Review.
Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Ashley N Suah, Dong-Kha V Tran, +8 authors, Anita S Chong.
J Clin Invest, 2021 Jan 05; 131(1). PMID: 33393512    Free PMC article.
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: An Overview.
Diederick J van Doorn, Robert Bart Takkenberg, Heinz-Josef Klümpen.
Pharmaceuticals (Basel), 2020 Dec 31; 14(1). PMID: 33374927    Free PMC article.
Review.
CTLA-4 expression by B-1a B cells is essential for immune tolerance.
Yang Yang, Xiao Li, +19 authors, Leonore A Herzenberg.
Nat Commun, 2021 Jan 24; 12(1). PMID: 33483505    Free PMC article.
Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression.
Jesse D Armitage, Hannah V Newnes, +2 authors, Jason Waithman.
Cells, 2021 Jan 07; 10(1). PMID: 33401460    Free PMC article.
Review.
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.
Blagoje Soskic, Louisa E Jeffery, +8 authors, David M Sansom.
Front Immunol, 2021 Jan 26; 11. PMID: 33488578    Free PMC article.
Glucocorticoids and immune checkpoint inhibitors in glioblastoma.
William J Kelly, Mark R Gilbert.
J Neurooncol, 2020 Feb 29; 151(1). PMID: 32108294
Review.
CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent-Relapse Minimal Change Disease.
Yoong Mond Teh, Soo Kun Lim, +2 authors, Siti Aisyah Mualif.
Biomed Res Int, 2021 Jan 29; 2021. PMID: 33506028    Free PMC article.
Review.
SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis.
Parisa Shiri Aghbash, Narges Eslami, +2 authors, Hossein Bannazadeh Baghi.
Life Sci, 2021 Jan 29; 270. PMID: 33508291    Free PMC article.
Review.
Intestinal Regulatory T Cells.
Vanessa R Figliuolo da Paz, Deepa R Jamwal, Pawel R Kiela.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523448
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy.
H Ryan Kolb, Nicholas Borcherding, Weizhou Zhang.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523451
Modulation of regulatory T cell function and stability by co-inhibitory receptors.
Liliana E Lucca, Margarita Dominguez-Villar.
Nat Rev Immunol, 2020 Apr 10; 20(11). PMID: 32269380
Review.
The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes.
Amira Kohil, Maha Al-Asmakh, Mashael Al-Shafai, Annalisa Terranegra.
Front Nutr, 2021 Feb 16; 7. PMID: 33585535    Free PMC article.
Review.
Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune homeostasis against lipopolysaccharide-induced inflammatory responses in broilers.
Rujiu Hu, Hua Lin, +6 authors, Mingming Yang.
J Anim Sci Biotechnol, 2021 Feb 18; 12(1). PMID: 33593426    Free PMC article.
Immune profiles in primary squamous cell carcinoma of the head and neck.
Vassiliki Saloura, Evgeny Izumchenko, +22 authors, Tanguy Y Seiwert.
Oral Oncol, 2019 Aug 20; 96. PMID: 31422218    Free PMC article.
Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation.
Caroline Dudreuilh, Sumoyee Basu, +2 authors, Giovanna Lombardi.
Front Immunol, 2021 Feb 20; 11. PMID: 33603742    Free PMC article.
Review.
Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms.
Jianyu Chen, Honghao Zhang, +4 authors, Yuhua Li.
Front Oncol, 2021 Feb 23; 10. PMID: 33614478    Free PMC article.
Review.
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment.
Lesang Shen, Yunxiang Zhou, +6 authors, Jian Huang.
Oxid Med Cell Longev, 2021 Feb 26; 2021. PMID: 33628389    Free PMC article.
Review.
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity.
Vittoria Palmieri, Jana-Fabienne Ebel, +10 authors, Astrid M Westendorf.
Mucosal Immunol, 2021 Mar 04; 14(4). PMID: 33654214    Free PMC article.
A novel Foxp3-related immune prognostic signature for glioblastoma multiforme based on immunogenomic profiling.
Xiao-Yu Guo, Guan-Hua Zhang, +9 authors, Yong-Gao Mou.
Aging (Albany NY), 2021 Jan 12; 13(3). PMID: 33429364    Free PMC article.
Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.
Javid Moslehi, Andrew H Lichtman, +2 authors, Richard N Kitsis.
J Clin Invest, 2021 Mar 02; 131(5). PMID: 33645548    Free PMC article.
Review.
A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability.
Yikui Li, Helen M Tunbridge, +8 authors, Christoph Wülfing.
Cells, 2021 Mar 07; 10(2). PMID: 33671236    Free PMC article.
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, +8 authors, Chun-Bing Chen.
Front Immunol, 2021 Mar 16; 12. PMID: 33717075    Free PMC article.
Review.
"Complimenting the Complement": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma.
Astha Malik, Unmesha Thanekar, +4 authors, Pranavkumar Shivakumar.
Front Oncol, 2021 Mar 16; 10. PMID: 33718121    Free PMC article.
Review.
Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers.
Sandra Ortiz-Cuaran, Jebrane Bouaoud, +2 authors, Pierre Saintigny.
Front Oncol, 2021 Mar 16; 11. PMID: 33718169    Free PMC article.
Review.
Use of checkpoint inhibitors in patients with lymphoid malignancies receiving allogeneic cell transplantation: a review.
Sabela Bobillo, Juan Camilo Nieto, Pere Barba.
Bone Marrow Transplant, 2021 Mar 21; 56(8). PMID: 33742152
Review.
Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19-IL2 cures poorly immunogenic tumors when combined with radiotherapy.
Veronica Olivo Pimentel, Damiënne Marcus, +8 authors, Philippe Lambin.
J Immunother Cancer, 2021 Mar 11; 9(3). PMID: 33688020    Free PMC article.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Review.
Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer.
Pilar Martín, Rafael Blanco-Domínguez, Raquel Sánchez-Díaz.
Cell Mol Immunol, 2020 Nov 26; 18(4). PMID: 33235388    Free PMC article.
Review.
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Navid Sobhani, Dana Rae Tardiel-Cyril, +3 authors, Yong Li.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974    Free PMC article.
Review.
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts.
Yini Sun, Jerome C Anyalebechi, +6 authors, Mandy L Ford.
JCI Insight, 2021 Mar 09; 6(5). PMID: 33682797    Free PMC article.
Engaging the Innate and Adaptive Antitumor Immune Response in Lymphoma.
Clifford M Csizmar, Stephen M Ansell.
Int J Mol Sci, 2021 Apr 04; 22(7). PMID: 33804869    Free PMC article.
Review.
Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma.
Jingtao Chen, Jiefeng Yang, +7 authors, Ming Song.
Mol Oncol, 2021 Jan 30; 15(4). PMID: 33513276    Free PMC article.
Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.
Emilie Ronin, Charlotte Pouchy, +15 authors, Benoît L Salomon.
Proc Natl Acad Sci U S A, 2021 Mar 27; 118(13). PMID: 33766913    Free PMC article.
A snapshot of the PD-1/PD-L1 pathway.
Chinmoy Ghosh, Gary Luong, Yue Sun.
J Cancer, 2021 Apr 16; 12(9). PMID: 33854633    Free PMC article.
Review.
CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.
Roberta Zappasodi, Inna Serganova, +21 authors, Taha Merghoub.
Nature, 2021 Feb 16; 591(7851). PMID: 33588426    Free PMC article.
Inhibition of acid sphingomyelinase increases regulatory T cells in humans.
Teresa Wiese, Fabio Dennstädt, +16 authors, Niklas Beyersdorf.
Brain Commun, 2021 Apr 27; 3(2). PMID: 33898989    Free PMC article.
Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications.
Yi Dong, Cuiping Yang, Fan Pan.
Front Immunol, 2021 Apr 30; 12. PMID: 33912156    Free PMC article.
Review.
Metabolic barriers to cancer immunotherapy.
Kristin DePeaux, Greg M Delgoffe.
Nat Rev Immunol, 2021 May 01; 21(12). PMID: 33927375  &n