Review
. 2008 Oct;42().
doi: 10.1016/j.yasu.2008.03.002.

Gene expression profiling of breast cancer

Ting Bao 1 Nancy E Davidson  
Affiliations
  • PMID: 18953822
  •     26 References
  •     10 citations

Abstract

Gene expression profiling is enabling scientists to understand the heterogeneous nature of breast cancer on a genomic level. Several gene expression profiles for breast cancers have emerged in the initial studies and appear to be generally concordant in their ability to predict poor outcome. Of these profiles, the Oncotype Dx and Mammaprint assays are the best validated and are commercially available. Their role in clinical practice is being refined through ongoing clinical trials. Other efforts are directed at determining host factors that might help identify prognosis as well as response and toxicity of therapy. It is expected that availability of these types of analyses will only increase in the future. It will be imperative that such assays be well validated and have implications for how to modify care for the individual patient.

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
T Sørlie, C M Perou, +14 authors, A L Børresen-Dale.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815    Free PMC article.
Highly Cited.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
Molecular profiling in breast cancer.
Shannon R Morris, Lisa A Carey.
Rev Endocr Metab Disord, 2007 Apr 28; 8(3). PMID: 17464566
Review.
Role of CYP2D6 testing in selection of endocrine therapy for breast cancer.
Justin Stebbing, Vered Stearns, Nancy E Davidson.
Pharmacogenomics, 2006 Dec 26; 8(1). PMID: 17187500
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer.
Marc Buyse, Sherene Loi, +18 authors, TRANSBIG Consortium.
J Natl Cancer Inst, 2006 Sep 07; 98(17). PMID: 16954471
Highly Cited.
Concordance among gene-expression-based predictors for breast cancer.
Cheng Fan, Daniel S Oh, +5 authors, Charles M Perou.
N Engl J Med, 2006 Aug 11; 355(6). PMID: 16899776
Highly Cited.
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients.
Laurel A Habel, Steven Shak, +12 authors, Charles P Quesenberry.
Breast Cancer Res, 2006 Jun 02; 8(3). PMID: 16737553    Free PMC article.
Highly Cited.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Microarray analysis and tumor classification.
John Quackenbush.
N Engl J Med, 2006 Jun 09; 354(23). PMID: 16760446
Highly Cited. Review.
Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer.
John A Foekens, David Atkins, +17 authors, Yixin Wang.
J Clin Oncol, 2006 Mar 01; 24(11). PMID: 16505412
NCCN Task Force Report: Adjuvant Therapy for Breast Cancer.
Robert W Carlson, Elizabeth Brown, +13 authors, National Comprehensive Cancer Network.
J Natl Compr Canc Netw, 2006 Mar 02; 4 Suppl 1. PMID: 16507275
Review.
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
Matthew P Goetz, James M Rae, +10 authors, James N Ingle.
J Clin Oncol, 2005 Dec 20; 23(36). PMID: 16361630
Highly Cited.
Gene expression profiling of breast cancer: a new tumor marker.
Laura J van't Veer, Soonmyung Paik, Daniel F Hayes.
J Clin Oncol, 2005 Mar 10; 23(8). PMID: 15755970
Review.
Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer.
Luca Gianni, Milvia Zambetti, +14 authors, Steven Shak.
J Clin Oncol, 2005 Sep 08; 23(29). PMID: 16145055
Highly Cited.
Quantitative monitoring of gene expression patterns with a complementary DNA microarray.
M Schena, D Shalon, R W Davis, P O Brown.
Science, 1995 Oct 20; 270(5235). PMID: 7569999
Highly Cited.
Using oligonucleotide probe arrays to access genetic diversity.
R J Lipshutz, D Morris, +6 authors, S P Fodor.
Biotechniques, 1995 Sep 01; 19(3). PMID: 7495558
Review.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang, Jan G M Klijn, +11 authors, John A Foekens.
Lancet, 2005 Feb 22; 365(9460). PMID: 15721472
Highly Cited.
Findings from recent National Surgical Adjuvant Breast and Bowel Project adjuvant studies in stage I breast cancer.
B Fisher, J H Jeong, +4 authors, N Wolmark.
J Natl Cancer Inst Monogr, 2002 Jan 05; (30). PMID: 11773294
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998.
Christopher I Li, Janet R Daling, Kathleen E Malone.
J Clin Oncol, 2002 Dec 31; 21(1). PMID: 12506166
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein.
Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800    Free PMC article.
Highly Cited.
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Xiao-Jun Ma, Zuncai Wang, +27 authors, Dennis C Sgroi.
Cancer Cell, 2004 Jun 15; 5(6). PMID: 15193263
Highly Cited.
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Howard Y Chang, Julie B Sneddon, +7 authors, Patrick O Brown.
PLoS Biol, 2004 Jan 23; 2(2). PMID: 14737219    Free PMC article.
Highly Cited.
Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay.
Maureen Cronin, Mylan Pho, +5 authors, Joffre B Baker.
Am J Pathol, 2003 Dec 26; 164(1). PMID: 14695316    Free PMC article.
Highly Cited.
GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example.
Ivan P Gorlov, Gary E Gallick, +2 authors, Christopher J Logothetis.
PLoS One, 2009 Aug 05; 4(8). PMID: 19652704    Free PMC article.
Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile.
K Graham, A de las Morenas, +10 authors, C L Rosenberg.
Br J Cancer, 2010 Mar 04; 102(8). PMID: 20197764    Free PMC article.
Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer.
Rachel C Jankowitz, Kristine Cooper, +5 authors, Adam Brufsky.
Breast Cancer Res, 2011 Oct 18; 13(5). PMID: 21999244    Free PMC article.
The effect of Oncotype DX recurrence score on treatment recommendations for patients with estrogen receptor-positive early stage breast cancer and correlation with estimation of recurrence risk by breast cancer specialists.
Jennifer E Joh, Nicole N Esposito, +10 authors, Geza Acs.
Oncologist, 2011 Oct 22; 16(11). PMID: 22016474    Free PMC article.
Fertility Preservation for the Young Breast Cancer Patient.
Shari B Goldfarb, Sabrina A Kamer, +6 authors, Mary L Gemignani.
Ann Surg Oncol, 2016 Jan 23; 23(5). PMID: 26790670    Free PMC article.
Estimating the OncotypeDX score: validation of an inexpensive estimation tool.
Anne A Eaton, Catherine E Pesce, +5 authors, Mahmoud El-Tamer.
Breast Cancer Res Treat, 2016 Dec 09; 161(3). PMID: 27928699    Free PMC article.
Understanding breast cancer - The long and winding road.
Kiven Erique Lukong.
BBA Clin, 2017 Feb 15; 7. PMID: 28194329    Free PMC article.
Review.
Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway.
LingLi Hou, Jiancheng Tu, +6 authors, Guojun Zhou.
Cancer Cell Int, 2018 Sep 27; 18. PMID: 30250400    Free PMC article.
Collective effects of long-range DNA methylations predict gene expressions and estimate phenotypes in cancer.
Soyeon Kim, Hyun Jung Park, Xiangqin Cui, Degui Zhi.
Sci Rep, 2020 Mar 05; 10(1). PMID: 32127627    Free PMC article.
Independent Prognostic Value of Intratumoral Heterogeneity and Immune Response Features by Automated Digital Immunohistochemistry Analysis in Early Hormone Receptor-Positive Breast Carcinoma.
Dovile Zilenaite, Allan Rasmusson, +5 authors, Arvydas Laurinavicius.
Front Oncol, 2020 Jul 03; 10. PMID: 32612954    Free PMC article.