Journal Article
. 2008 Dec; 100(1):113-7.
doi: 10.1038/sj.bjc.6604812.

Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40

E Oflazoglu 1 I J Stone  L Brown  K A Gordon  N van Rooijen  M Jonas  C-L Law  I S Grewal  H-P Gerber  
Affiliations
  • PMID: 19066610
  •     19 References
  •     28 citations

Abstract

SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions.

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