Journal Article
. 2008 Dec; 105(51):20410-5.
doi: 10.1073/pnas.0810114105.

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

Jianda Yuan 1 Sacha Gnjatic  Hao Li  Sarah Powel  Humilidad F Gallardo  Erika Ritter  Geoffrey Y Ku  Achim A Jungbluth  Neil H Segal  Teresa S Rasalan  Gregor Manukian  Yinyan Xu  Ruth-Ann Roman  Stephanie L Terzulli  Melanie Heywood  Evelina Pogoriler  Gerd Ritter  Lloyd J Old  James P Allison  Jedd D Wolchok  
Affiliations
  • PMID: 19074257
  •     32 References
  •     159 citations

Abstract

Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-4 therapy on human immune responses is still unclear. To explore this, we analyzed immune-related adverse events and immune responses in metastatic melanoma patients treated with ipilimumab, a fully human anti-CTLA-4 monoclonal antibody. Fifteen patients were selected on the basis of availability of suitable specimens for immunologic monitoring, and eight of these showed evidence of clinical benefit. Five of the eight patients with evidence of clinical benefit had NY-ESO-1 antibody, whereas none of seven clinical non-responders was seropositive for NY-ESO-1. All five NY-ESO-1 seropositive patients had clearly detectable CD4(+) and CD8(+) T cells against NY-ESO-1 following treatment with ipilimumab. One NY-ESO-1 seronegative clinical responder also had a NY-ESO-1 CD4(+) and CD8(+) T cell response, possibly related to prior vaccination with NY-ESO-1. Among five clinical non-responders analyzed, only one had a NY-ESO-1 CD4(+) T cell response and this patient did not have detectable anti-NY-ESO-1 antibody. Overall, NY-ESO-1-specific T cell responses increased in frequency and functionality during anti-CTLA-4 treatment, revealing a polyfunctional response pattern of IFN-gamma, MIP-1beta and TNF-alpha. We therefore suggest that CTLA-4 blockade enhanced NY-ESO-1 antigen-specific B cell and T cell immune responses in patients with durable objective clinical responses and stable disease. These data provide an immunologic rationale for the efficacy of anti-CTLA-4 therapy and call for immunotherapeutic designs that combine NY-ESO-1 vaccination with CTLA-4 blockade.

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CTLA4 blockade broadens the peripheral T-cell receptor repertoire.
Lidia Robert, Jennifer Tsoi, +11 authors, Antoni Ribas.
Clin Cancer Res, 2014 Mar 04; 20(9). PMID: 24583799    Free PMC article.
Highly Cited.
Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells.
Smita K Nair, Gabriel De Leon, +9 authors, Duane A Mitchell.
Clin Cancer Res, 2014 Mar 25; 20(10). PMID: 24658154    Free PMC article.
Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma.
Jianda Yuan, Geoffrey Y Ku, +9 authors, Jedd D Wolchok.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829756    Free PMC article.
Bevacizumab plus ipilimumab in patients with metastatic melanoma.
F Stephen Hodi, Donald Lawrence, +20 authors, David McDermott.
Cancer Immunol Res, 2014 May 20; 2(7). PMID: 24838938    Free PMC article.
Highly Cited.
Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.
Yi-Chi M Kong, Jeffrey C Flynn.
Front Immunol, 2014 Jun 07; 5. PMID: 24904570    Free PMC article.
Review.
FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4(+) T regulatory cells.
Walter Moises Tobias Braga, Bruna Raphaeli da Silva, +5 authors, Gisele Wally Braga Colleoni.
Cancer Immunol Immunother, 2014 Aug 08; 63(11). PMID: 25099367    Free PMC article.
Molecular regulation of effector and memory T cell differentiation.
John T Chang, E John Wherry, Ananda W Goldrath.
Nat Immunol, 2014 Nov 15; 15(12). PMID: 25396352    Free PMC article.
Highly Cited. Review.
Vaccines versus immunotherapy: overview of approaches in deciding between options.
Angus G Dalgleish.
Hum Vaccin Immunother, 2015 Jan 28; 10(11). PMID: 25625932    Free PMC article.
Review.
Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma.
Rachel Lubong Sabado, Anna Pavlick, +22 authors, Nina Bhardwaj.
Cancer Immunol Res, 2015 Jan 31; 3(3). PMID: 25633712    Free PMC article.
Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience.
J Gao, Q He, +6 authors, P Sharma.
Oncogene, 2015 Feb 11; 34(43). PMID: 25659583    Free PMC article.
Review.
Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection.
Anders Boyd, Jorge R Almeida, +5 authors, Martin Larsen.
PLoS One, 2015 Jun 06; 10(6). PMID: 26046523    Free PMC article.
Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.
Maud Condomines, Jon Arnason, +3 authors, Michel Sadelain.
PLoS One, 2015 Jun 26; 10(6). PMID: 26110267    Free PMC article.
Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.
Oscar Silva, Jillian Crocetti, +2 authors, M Carrie Miceli.
PLoS One, 2015 Jul 18; 10(7). PMID: 26186728    Free PMC article.
NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.
Aaron P Rapoport, Edward A Stadtmauer, +32 authors, Carl H June.
Nat Med, 2015 Jul 21; 21(8). PMID: 26193344    Free PMC article.
Highly Cited.
Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.
Jianbin Wang, Joshua J DeClercq, +5 authors, Michael C Holmes.
Nucleic Acids Res, 2015 Nov 04; 44(3). PMID: 26527725    Free PMC article.
The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNFα/IL17 Dependent.
Vy Phan-Lai, Yushe Dang, +2 authors, Mary L Disis.
Clin Cancer Res, 2015 Dec 15; 22(9). PMID: 26660518    Free PMC article.
Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations.
Michael P Castro, Neal Goldstein.
J Immunother Cancer, 2015 Dec 18; 3. PMID: 26674132    Free PMC article.
Novel technologies and emerging biomarkers for personalized cancer immunotherapy.
Jianda Yuan, Priti S Hegde, +16 authors, Bernard A Fox.
J Immunother Cancer, 2016 Jan 21; 4. PMID: 26788324    Free PMC article.
Highly Cited. Review.
Emerging Tissue and Blood-Based Biomarkers that may Predict Response to Immune Checkpoint Inhibition.
Claire F Friedman, Michael A Postow.
Curr Oncol Rep, 2016 Feb 29; 18(4). PMID: 26922327    Free PMC article.
Review.
Long-lasting multifunctional CD8+ T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination.
Florian Wimmers, Erik H J G Aarntzen, +4 authors, I Jolanda M de Vries.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942087    Free PMC article.
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.
Holbrook E Kohrt, Paul C Tumeh, +33 authors, Cancer Immunotherapy Trials Network (CITN).
J Immunother Cancer, 2016 Mar 17; 4. PMID: 26981245    Free PMC article.
Review.
Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study.
Cristina Maccalli, Diana Giannarelli, +5 authors, Michele Maio.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057436    Free PMC article.
SHP-1: the next checkpoint target for cancer immunotherapy?
H Angharad Watson, Sophie Wehenkel, James Matthews, Ann Ager.
Biochem Soc Trans, 2016 Apr 14; 44(2). PMID: 27068940    Free PMC article.
Review.
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.
Suzanne L Topalian, Janis M Taube, Robert A Anders, Drew M Pardoll.
Nat Rev Cancer, 2016 Apr 16; 16(5). PMID: 27079802    Free PMC article.
Highly Cited. Review.
TNFRSF14 aberrations in follicular lymphoma increase clinically significant allogeneic T-cell responses.
Eleni Kotsiou, Jessica Okosun, +5 authors, Jeffrey K Davies.
Blood, 2016 Apr 23; 128(1). PMID: 27103745    Free PMC article.
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab.
Alexander Martens, Kilian Wistuba-Hamprecht, +15 authors, Benjamin Weide.
Clin Cancer Res, 2016 May 14; 22(19). PMID: 27169993    Free PMC article.
Highly Cited.
Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies.
Marianna Sabatino, Jinhui Hu, +12 authors, Luca Gattinoni.
Blood, 2016 May 27; 128(4). PMID: 27226436    Free PMC article.
Highly Cited.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy.
Weijie Ma, Barbara M Gilligan, Jianda Yuan, Tianhong Li.
J Hematol Oncol, 2016 May 29; 9(1). PMID: 27234522    Free PMC article.
Highly Cited. Review.
Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy.
Weizhou Hou, Padma Sampath, Juan J Rojas, Steve H Thorne.
Cancer Cell, 2016 Jul 05; 30(1). PMID: 27374223    Free PMC article.
HLA ligandomics identifies histone deacetylase 1 as target for ovarian cancer immunotherapy.
Janet Kerstin Peper, Hans-Christian Bösmüller, +9 authors, Annette Staebler.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467910    Free PMC article.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Ornella Franzese, Belinda Palermo, +6 authors, Paola Nisticò.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467927    Free PMC article.
IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.
Zhi-Chun Ding, Chufeng Liu, +10 authors, Gang Zhou.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471650    Free PMC article.
T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities.
Zhan Wang, Binghao Li, Yingqing Ren, Zhaoming Ye.
Front Immunol, 2016 Sep 30; 7. PMID: 27683579    Free PMC article.
Review.
Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells.
Shu Wang, Jose Campos, +5 authors, Cristiana Guiducci.
Proc Natl Acad Sci U S A, 2016 Nov 02; 113(46). PMID: 27799536    Free PMC article.
Highly Cited.
The role of immune checkpoint inhibition in the treatment of ovarian cancer.
Stéphanie L Gaillard, Angeles A Secord, Bradley Monk.
Gynecol Oncol Res Pract, 2016 Dec 03; 3. PMID: 27904752    Free PMC article.
Review.
Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire.
David Y Oh, Jason Cham, +5 authors, Lawrence Fong.
Cancer Res, 2016 Dec 30; 77(6). PMID: 28031229    Free PMC article.
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy.
Jon Amund Kyte, Gustav Gaudernack, +7 authors, Martin Pule.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123886    Free PMC article.
Immunoregulatory functions of VISTA.
Elizabeth C Nowak, J Louise Lines, +7 authors, Randolph J Noelle.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258694    Free PMC article.
Highly Cited. Review.
Precision medicine driven by cancer systems biology.
Fabian V Filipp.
Cancer Metastasis Rev, 2017 Mar 08; 36(1). PMID: 28265786    Free PMC article.
The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.
Aditya Arra, Holger Lingel, +6 authors, Monika C Brunner-Weinzierl.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344884    Free PMC article.
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
Rakesh R Ramjiawan, Arjan W Griffioen, Dan G Duda.
Angiogenesis, 2017 Apr 01; 20(2). PMID: 28361267    Free PMC article.
Highly Cited. Review.
Twelve-year survival and immune correlates in dendritic cell-vaccinated melanoma patients.
Stefanie Gross, Michael Erdmann, +12 authors, Beatrice Schuler-Thurner.
JCI Insight, 2017 Apr 20; 2(8). PMID: 28422751    Free PMC article.
Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy.
Sacha Gnjatic, Vincenzo Bronte, +13 authors, Lisa H Butterfield.
J Immunother Cancer, 2017 May 19; 5. PMID: 28515944    Free PMC article.
Highly Cited. Review.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer.
Anderly C Chüeh, Mun-Sem Liew, +8 authors, Thomas John.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088766    Free PMC article.
Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence.
Stefanie R Bailey, Michelle H Nelson, +9 authors, Chrystal M Paulos.
Nat Commun, 2017 Dec 08; 8(1). PMID: 29213079    Free PMC article.
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression.
Chungyong Han, Su-Jung Sim, +11 authors, Byoung S Kwon.
Nat Commun, 2018 Feb 03; 9(1). PMID: 29391449    Free PMC article.
Polyfunctionality of CD4+ T lymphocytes is increased after chemoradiotherapy of head and neck squamous cell carcinoma.
J Doescher, S Jeske, +6 authors, P J Schuler.
Strahlenther Onkol, 2018 Apr 18; 194(5). PMID: 29663037
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
Remy Thomas, Ghaneya Al-Khadairi, +4 authors, Julie Decock.
Front Immunol, 2018 May 18; 9. PMID: 29770138    Free PMC article.
Highly Cited. Review.
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma.
Janet Retseck, Alexis Nasr, +4 authors, Ahmad A Tarhini.
J Transl Med, 2018 Jul 06; 16(1). PMID: 29973204    Free PMC article.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Todd A Triplett, Kendra C Garrison, +23 authors, George Georgiou.
Nat Biotechnol, 2018 Jul 17; 36(8). PMID: 30010674    Free PMC article.
A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia.
Arjan A van de Loosdrecht, Sandra van Wetering, +8 authors, Tanja D de Gruijl.
Cancer Immunol Immunother, 2018 Jul 25; 67(10). PMID: 30039426    Free PMC article.
Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy.
Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes Vom Berg.
Front Oncol, 2018 Aug 10; 8. PMID: 30090763    Free PMC article.
Review.
B cells and antibody production in melanoma.
Jessica Da Gama Duarte, Janique M Peyper, Jonathan M Blackburn.
Mamm Genome, 2018 Sep 05; 29(11-12). PMID: 30178304
Review.
Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic review.
Wouter Ouwerkerk, Mirjam van den Berg, +2 authors, Rosalie M Luiten.
Melanoma Res, 2019 Mar 12; 29(5). PMID: 30855527    Free PMC article.
Systematic Review.
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease.
Peter A Szabo, Hanna Mendes Levitin, +9 authors, Peter A Sims.
Nat Commun, 2019 Oct 19; 10(1). PMID: 31624246    Free PMC article.
Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation.
Hester J Scheffer, Anita G M Stam, +7 authors, Tanja D de Gruijl.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646081    Free PMC article.
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.
Chaofan Li, Bibo Zhu, +18 authors, Jie Sun.
Immunity, 2019 Sep 19; 51(3). PMID: 31533057    Free PMC article.
Highly Cited.
Therapeutic proteins.
Dimiter S Dimitrov.
Methods Mol Biol, 2012 Jun 28; 899. PMID: 22735943    Free PMC article.
Review.
TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma.
Brenda De Keersmaecker, Sofie Claerhout, +5 authors, Kris Thielemans.
J Immunother Cancer, 2020 Mar 03; 8(1). PMID: 32114500    Free PMC article.
Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients.
Tara M Robinson, Gabrielle T Prince, +6 authors, B Douglas Smith.
Leuk Lymphoma, 2018 Apr 05; 59(12). PMID: 29616857    Free PMC article.
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells.
Sema Kurtulus, Asaf Madi, +10 authors, Ana C Anderson.
Immunity, 2019 Jan 13; 50(1). PMID: 30635236    Free PMC article.
Highly Cited.
Breast Tumor Cells Highly Resistant to Drugs Are Controlled Only by the Immune Response Induced in an Immunocompetent Mouse Model.
Paola Lasso, Mónica Llano Murcia, +3 authors, Susana Fiorentino.
Integr Cancer Ther, 2019 May 07; 18. PMID: 31056957    Free PMC article.
The B-side of Cancer Immunity: The Underrated Tune.
Anne Largeot, Giulia Pagano, +2 authors, Jerome Paggetti.
Cells, 2019 May 16; 8(5). PMID: 31086070    Free PMC article.
Review.
Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma.
Akiko Arakawa, Sigrid Vollmer, +5 authors, Jörg C Prinz.
Front Immunol, 2019 Jul 06; 10. PMID: 31275310    Free PMC article.
Polymorphic Region-Specific Antibody for Evaluation of Affinity-Associated Profile of Chimeric Antigen Receptor.
Chungyong Han, Beom K Choi, +10 authors, Byoung S Kwon.
Mol Ther Oncolytics, 2020 May 06; 17. PMID: 32368617    Free PMC article.
CD4+ T cells support polyfunctionality of cytotoxic CD8+ T cells with memory potential in immunological control of tumor.
Naoko Imai, Isao Tawara, +3 authors, Hiroaki Ikeda.
Cancer Sci, 2020 Apr 19; 111(6). PMID: 32304127    Free PMC article.
Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient.
Giovanni Rossi, Alessandro Russo, +13 authors, Carlo Genova.
Cancers (Basel), 2020 May 06; 12(5). PMID: 32365882    Free PMC article.
Review.
Annona muricata L.-Derived Polysaccharides as a Potential Adjuvant to a Dendritic Cell-Based Vaccine in a Thymoma-Bearing Model.
Woo Sik Kim, Jeong Moo Han, +3 authors, Eui-Baek Byun.
Nutrients, 2020 Jun 04; 12(6). PMID: 32486094    Free PMC article.
Edible Oxya chinensis sinuosa-Derived Protein as a Potential Nutraceutical for Anticancer Immunity Improvement.
Woo Sik Kim, Jeong Moo Han, +3 authors, Eui-Baek Byun.
Nutrients, 2020 Oct 28; 12(11). PMID: 33105813    Free PMC article.
Liposome-Based Drug Delivery Systems in Cancer Immunotherapy.
Zili Gu, Candido G Da Silva, +2 authors, Luis J Cruz.
Pharmaceutics, 2020 Nov 08; 12(11). PMID: 33158166    Free PMC article.
Review.
Nanomaterial-Based Tumor Photothermal Immunotherapy.
Peng Xu, Feng Liang.
Int J Nanomedicine, 2020 Nov 28; 15. PMID: 33244232    Free PMC article.
Review.
No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma.
Stephanie L Goff, Paul F Robbins, Mona El-Gamil, Steven A Rosenberg.
J Immunother, 2009 Sep 16; 32(8). PMID: 19752745    Free PMC article.
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
Highly Cited.
The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy.
Anastasia Mpakali, Efstratios Stratikos.
Cancers (Basel), 2021 Jan 08; 13(1). PMID: 33406696    Free PMC article.
Review.
Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression.
Jesse D Armitage, Hannah V Newnes, +2 authors, Jason Waithman.
Cells, 2021 Jan 07; 10(1). PMID: 33401460    Free PMC article.
Review.
Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity.
Allan Relecom, Maysaloun Merhi, +4 authors, Said Dermime.
J Exp Clin Cancer Res, 2021 Feb 20; 40(1). PMID: 33602280    Free PMC article.
Review.
Varied functions of immune checkpoints during cancer metastasis.
Ali Safarzadeh, Mohsen Alizadeh, +7 authors, Nicola Silvestris.
Cancer Immunol Immunother, 2020 Sep 10; 70(3). PMID: 32902664    Free PMC article.
Review.
Cancer Vaccines: Antigen Selection Strategy.
Yue Zhao, Alexey V Baldin, +3 authors, Alexandr V Bazhin.
Vaccines (Basel), 2021 Jan 29; 9(2). PMID: 33503926    Free PMC article.
Review.
Tumor LAG-3 and NY-ESO-1 expression predict durable clinical benefits of immune checkpoint inhibitors in advanced non-small cell lung cancer.
Eun Hee Jung, Hee Ryeong Jang, +10 authors, Jong Seok Lee.
Thorac Cancer, 2021 Jan 19; 12(5). PMID: 33458968    Free PMC article.
Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma.
Franziska K Krebs, Emily R Trzeciak, +6 authors, Andrea Tuettenberg.
Cancer Med, 2021 Jan 16; 10(5). PMID: 33449393    Free PMC article.
A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma.
Craig L Slingluff, Hassane M Zarour, +13 authors, Jedd D Wolchok.
Oncoimmunology, 2021 Apr 03; 10(1). PMID: 33796406    Free PMC article.
CD19 Chimeric Antigen Receptor T Cells From Patients With Chronic Lymphocytic Leukemia Display an Elevated IFN-γ Production Profile.
Isabelle Magalhaes, Ingrid Kalland, +3 authors, Jonas Mattsson.
J Immunother, 2018 Jan 10; 41(2). PMID: 29315094    Free PMC article.
Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer.
Hoang Dang Khoa Ta, Wan-Chun Tang, +7 authors, Chih-Yang Wang.
Diagnostics (Basel), 2021 May 01; 11(4). PMID: 33921749    Free PMC article.
T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects.
Spyridoula Vasileiou, Premal D Lulla, +19 authors, George Carrum.
J Clin Oncol, 2021 Jan 29; 39(13). PMID: 33507803    Free PMC article.
Relationship between Kita-Kyushu Lung Cancer antigen-1 expression and prognosis of cases with lung squamous cell carcinoma.
Yoshinobu Ichiki, Takashi Fukuyama, +8 authors, Tsuyoshi Ishida.
Transl Cancer Res, 2022 Feb 05; 10(12). PMID: 35116371    Free PMC article.
Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets.
Nina Bhardwaj, Philip A Friedlander, +31 authors, Steven P Fling.
Nat Cancer, 2020 Dec 01; 1(12). PMID: 35121932
A genome-scale screen for synthetic drivers of T cell proliferation.
Mateusz Legut, Zoran Gajic, +11 authors, Neville E Sanjana.
Nature, 2022 Mar 18; 603(7902). PMID: 35296855
Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
Andrea Aran, Laia Garrigós, +2 authors, Mercè Martí.
Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406543    Free PMC article.
Review.