Review
. 2009 Mar; 21(2):215-23.
doi: 10.1016/j.coi.2009.02.009.

The promise and potential pitfalls of chimeric antigen receptors

Michel Sadelain 1 Renier Brentjens  Isabelle Rivière  
Affiliations
  • PMID: 19327974
  •     120 References
  •     212 citations

Abstract

One important purpose of T cell engineering is to generate tumor-targeted T cells through the genetic transfer of antigen-specific receptors, which consist of either physiological, MHC-restricted T cell receptors (TCRs) or non MHC-restricted chimeric antigen receptors (CARs). CARs combine antigen-specificity and T cell activating properties in a single fusion molecule. First generation CARs, which included as their signaling domain the cytoplasmic region of the CD3zeta or Fc receptor gamma chain, effectively redirected T cell cytotoxicity but failed to enable T cell proliferation and survival upon repeated antigen exposure. Receptors encompassing both CD28 and CD3zeta are the prototypes for second generation CARs, which are now rapidly expanding to a diverse array of receptors with different functional properties. First generation CARs have been tested in phase I clinical studies in patients with ovarian cancer, renal cancer, lymphoma, and neuroblastoma, where they have induced modest responses. Second generation CARs, which are just now entering the clinical arena in the B cell malignancies and other cancers, will provide a more significant test for this approach. If the immunogenicity of CARs can be averted, the versatility of their design and HLA-independent antigen recognition will make CARs tools of choice for T cell engineering for the development of targeted cancer immunotherapies.

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Blood, 2004 Oct 28; 105(4). PMID: 15507526
Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules.
M E Weijtens, R A Willemsen, B A van Krimpen, R L Bolhuis.
Int J Cancer, 1998 Jul 03; 77(2). PMID: 9650549
Transfer of chimeric receptor gene made of variable regions of tumor-specific antibody confers anticarbohydrate specificity on T cells.
D Mezzanzanica, S Canevari, +5 authors, Z Eshhar.
Cancer Gene Ther, 1999 Jan 23; 5(6). PMID: 9917095
Adoptive transfer of chimeric FcepsilonRI gene-modified human T cells for cancer immunotherapy.
Michele W L Teng, Michael H Kershaw, +2 authors, Phillip K Darcy.
Hum Gene Ther, 2006 Oct 21; 17(11). PMID: 17052145
Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.
Xin Huang, Hongfeng Guo, +13 authors, Xianzheng Zhou.
Mol Ther, 2008 Jan 30; 16(3). PMID: 18227839    Free PMC article.
Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection.
Maria Moeller, Nicole M Haynes, +8 authors, Phillip K Darcy.
Blood, 2005 Jul 21; 106(9). PMID: 16030195
Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor.
Scott Wilkie, Gianfranco Picco, +8 authors, John Maher.
J Immunol, 2008 Mar 21; 180(7). PMID: 18354214
Human monocytes expressing a CEA-specific chimeric CD64 receptor specifically target CEA-expressing tumour cells in vitro and in vivo.
A Biglari, T D Southgate, L J Fairbairn, D E Gilham.
Gene Ther, 2006 Jan 07; 13(7). PMID: 16397508
Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells.
Agnieszka Morgenroth, Marc Cartellieri, +6 authors, Achim Temme.
Prostate, 2007 May 12; 67(10). PMID: 17492652
Regression of experimental medulloblastoma following transfer of HER2-specific T cells.
Nabil Ahmed, Maheshika Ratnayake, +10 authors, Stephen Gottschalk.
Cancer Res, 2007 Jun 19; 67(12). PMID: 17575166
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts.
Renier J Brentjens, Elmer Santos, +6 authors, Michel Sadelain.
Clin Cancer Res, 2007 Sep 15; 13(18 Pt 1). PMID: 17855649
Highly Cited.
Adoptive T cell therapy of cancer.
Ton N M Schumacher, Nicholas P Restifo.
Curr Opin Immunol, 2009 Mar 31; 21(2). PMID: 19328668    Free PMC article.
Persuading natural killer cells to eliminate bad B cells.
Laurence J N Cooper.
Clin Cancer Res, 2009 Jul 30; 15(15). PMID: 19638468    Free PMC article.
Cellular therapies in acute lymphoblastic leukemia.
Renier J Brentjens.
Curr Opin Mol Ther, 2009 Aug 04; 11(4). PMID: 19649982    Free PMC article.
Review.
Fifteen years of gene therapy based on chimeric antigen receptors: "are we nearly there yet?".
Gianpietro Dotti, Barbara Savoldo, Malcolm Brenner.
Hum Gene Ther, 2009 Aug 26; 20(11). PMID: 19702437    Free PMC article.
Review.
Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.
Xiao-Song Zhong, Maiko Matsushita, +2 authors, Michel Sadelain.
Mol Ther, 2009 Sep 24; 18(2). PMID: 19773745    Free PMC article.
Highly Cited.
Engineering lymphocyte subsets: tools, trials and tribulations.
Carl H June, Bruce R Blazar, James L Riley.
Nat Rev Immunol, 2009 Oct 28; 9(10). PMID: 19859065    Free PMC article.
Review.
Immunotherapy of human cancers using gene modified T lymphocytes.
Juan F Vera, Malcolm K Brenner, Gianpietro Dotti.
Curr Gene Ther, 2009 Oct 29; 9(5). PMID: 19860654    Free PMC article.
Review.
Immune-based therapeutics for pediatric cancer.
Christian M Capitini, Crystal L Mackall, Alan S Wayne.
Expert Opin Biol Ther, 2009 Dec 02; 10(2). PMID: 19947897    Free PMC article.
Review.
Immunotherapy of childhood cancer: from biologic understanding to clinical application.
Alan S Wayne, Christian M Capitini, Crystal L Mackall.
Curr Opin Pediatr, 2009 Dec 03; 22(1). PMID: 19952749    Free PMC article.
Review.
Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer.
Robert R Jenq, Marcel R M van den Brink.
Nat Rev Cancer, 2010 Feb 20; 10(3). PMID: 20168320
Review.
Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation.
Scott E James, Philip D Greenberg, +7 authors, Oliver W Press.
J Immunol, 2010 Mar 12; 184(8). PMID: 20220093    Free PMC article.
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans.
Michael C Jensen, Leslie Popplewell, +4 authors, Stephen J Forman.
Biol Blood Marrow Transplant, 2010 Mar 23; 16(9). PMID: 20304086    Free PMC article.
Highly Cited.
Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial.
Renier Brentjens, Raymond Yeh, +2 authors, Michel Sadelain.
Mol Ther, 2010 Apr 02; 18(4). PMID: 20357779    Free PMC article.
Highly Cited.
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety.
V Hoyos, B Savoldo, +7 authors, G Dotti.
Leukemia, 2010 Apr 30; 24(6). PMID: 20428207    Free PMC article.
Highly Cited.
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.
Bipulendu Jena, Gianpietro Dotti, Laurence J N Cooper.
Blood, 2010 May 05; 116(7). PMID: 20439624    Free PMC article.
Highly Cited. Review.
Chimeric antigen receptor-engineered T cells for immunotherapy of cancer.
Marc Cartellieri, Michael Bachmann, +5 authors, Marc Schmitz.
J Biomed Biotechnol, 2010 May 15; 2010. PMID: 20467460    Free PMC article.
Review.
Designing customized cell signalling circuits.
Wendell A Lim.
Nat Rev Mol Cell Biol, 2010 May 21; 11(6). PMID: 20485291    Free PMC article.
Highly Cited. Review.
Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.
Scott Wilkie, Sophie E Burbridge, +6 authors, John Maher.
J Biol Chem, 2010 Jun 22; 285(33). PMID: 20562098    Free PMC article.
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies.
Edwin P Alyea, Daniel J DeAngelo, +7 authors, Stan Riddell.
Biol Blood Marrow Transplant, 2010 Jun 29; 16(8). PMID: 20580849    Free PMC article.
Review.
Cell-based immunotherapy of prion diseases by adoptive transfer of antigen-loaded dendritic cells or antigen-primed CD(4+) T lymphocytes.
Claude Carnaud, Véronique Bachy.
Prion, 2010 Jul 14; 4(2). PMID: 20622507    Free PMC article.
Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen.
Alena A Chekmasova, Thapi D Rao, +4 authors, Renier J Brentjens.
Clin Cancer Res, 2010 Jul 16; 16(14). PMID: 20628030    Free PMC article.
Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.
James N Kochenderfer, Zhiya Yu, +2 authors, Steven A Rosenberg.
Blood, 2010 Jul 16; 116(19). PMID: 20631379    Free PMC article.
Highly Cited.
Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects.
Myriam N Bouchlaka, Doug Redelman, William J Murphy.
Immunotherapy, 2010 Jul 20; 2(3). PMID: 20635904    Free PMC article.
Review.
Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19.
James N Kochenderfer, Wyndham H Wilson, +9 authors, Steven A Rosenberg.
Blood, 2010 Jul 30; 116(20). PMID: 20668228    Free PMC article.
Highly Cited.
Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors.
Virna Marin, Irene Pizzitola, +7 authors, Ettore Biagi.
Haematologica, 2010 Aug 18; 95(12). PMID: 20713459    Free PMC article.
Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor.
Yangbing Zhao, Edmund Moon, +9 authors, Carl H June.
Cancer Res, 2010 Oct 12; 70(22). PMID: 20926399    Free PMC article.
Highly Cited.
Immunotherapy for ovarian cancer: what's next?
Lana E Kandalaft, Daniel J Powell, Nathan Singh, George Coukos.
J Clin Oncol, 2010 Nov 17; 29(7). PMID: 21079136    Free PMC article.
Review.
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.
David H Aggen, Adam S Chervin, +3 authors, David M Kranz.
Protein Eng Des Sel, 2010 Dec 17; 24(4). PMID: 21159619    Free PMC article.
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.
George Silva, Laurent Poirot, +4 authors, Frédéric Pâques.
Curr Gene Ther, 2010 Dec 25; 11(1). PMID: 21182466    Free PMC article.
Review.
Focus on adoptive T cell transfer trials in melanoma.
Liat Hershkovitz, Jacob Schachter, Avraham J Treves, Michal J Besser.
Clin Dev Immunol, 2011 Jan 15; 2010. PMID: 21234353    Free PMC article.
Review.
Stem cell-based anti-HIV gene therapy.
Scott G Kitchen, Saki Shimizu, Dong Sung An.
Virology, 2011 Jan 21; 411(2). PMID: 21247612    Free PMC article.
Review.
CARs on track in the clinic.
Donald B Kohn, Gianpietro Dotti, +7 authors, Helen E Heslop.
Mol Ther, 2011 Mar 02; 19(3). PMID: 21358705    Free PMC article.
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor.
Greta Maria Paola Giordano Attianese, Virna Marin, +11 authors, Ettore Biagi.
Blood, 2011 Mar 17; 117(18). PMID: 21406718    Free PMC article.
Ex vivo gene transfer for improved adoptive immunotherapy of cancer.
Minhtran C Ngo, Cliona M Rooney, Jeffrey M Howard, Helen E Heslop.
Hum Mol Genet, 2011 Mar 19; 20(R1). PMID: 21415041    Free PMC article.
Review.
Synthetic conversion of a graded receptor signal into a tunable, reversible switch.
Santhosh Palani, Casim A Sarkar.
Mol Syst Biol, 2011 Apr 01; 7. PMID: 21451590    Free PMC article.
NKG2D receptor regulates human effector T-cell cytokine production.
Amorette Barber, Charles L Sentman.
Blood, 2011 Apr 27; 117(24). PMID: 21518928    Free PMC article.
Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes.
Itzhel García-Torres, Nallely Cabrera, +4 authors, Ruy Perez-Montfort.
PLoS One, 2011 May 03; 6(4). PMID: 21533154    Free PMC article.
CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients.
Barbara Savoldo, Carlos Almeida Ramos, +13 authors, Gianpietro Dotti.
J Clin Invest, 2011 May 05; 121(5). PMID: 21540550    Free PMC article.
Highly Cited.
Treating cancer with genetically engineered T cells.
Tristen S Park, Steven A Rosenberg, Richard A Morgan.
Trends Biotechnol, 2011 Jun 15; 29(11). PMID: 21663987    Free PMC article.
Review.
Chimeric Antigen Receptor Therapy for B-cell Malignancies.
David L Porter, Michael Kalos, +2 authors, Carl June.
J Cancer, 2011 Jul 01; 2. PMID: 21716851    Free PMC article.
Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.
D H Aggen, A S Chervin, +8 authors, D M Kranz.
Gene Ther, 2011 Jul 15; 19(4). PMID: 21753797    Free PMC article.
PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor.
Yozo Nakazawa, Leslie E Huye, +7 authors, Cliona M Rooney.
Mol Ther, 2011 Jul 21; 19(12). PMID: 21772253    Free PMC article.
Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.
David L Porter, Bruce L Levine, +2 authors, Carl H June.
N Engl J Med, 2011 Aug 13; 365(8). PMID: 21830940    Free PMC article.
Highly Cited.
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.
Michael Kalos, Bruce L Levine, +4 authors, Carl H June.
Sci Transl Med, 2011 Aug 13; 3(95). PMID: 21832238    Free PMC article.
Highly Cited.
Treatment of advanced leukemia in mice with mRNA engineered T cells.
David M Barrett, Yangbing Zhao, +6 authors, Stephan A Grupp.
Hum Gene Ther, 2011 Aug 16; 22(12). PMID: 21838572    Free PMC article.
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias.
Renier J Brentjens, Isabelle Rivière, +24 authors, Michel Sadelain.
Blood, 2011 Aug 19; 118(18). PMID: 21849486    Free PMC article.
Highly Cited.
Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination.
Leslie E Huye, Yozo Nakazawa, +6 authors, Cliona M Rooney.
Mol Ther, 2011 Sep 01; 19(12). PMID: 21878902    Free PMC article.
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.
Ning Li, Catherine Matte-Martone, +8 authors, Warren D Shlomchik.
Blood, 2011 Sep 16; 118(22). PMID: 21917752    Free PMC article.
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.
Chrystal U Louis, Barbara Savoldo, +14 authors, Malcolm K Brenner.
Blood, 2011 Oct 11; 118(23). PMID: 21984804    Free PMC article.
Highly Cited.
Cellular therapies in acute lymphoblastic leukemia.
Jae H Park, Craig Sauter, Renier Brentjens.
Hematol Oncol Clin North Am, 2011 Nov 19; 25(6). PMID: 22093587    Free PMC article.
Review.
Emerging biomedical applications of synthetic biology.
Wilfried Weber, Martin Fussenegger.
Nat Rev Genet, 2011 Nov 30; 13(1). PMID: 22124480    Free PMC article.
Highly Cited. Review.
B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.
James N Kochenderfer, Mark E Dudley, +15 authors, Steven A Rosenberg.
Blood, 2011 Dec 14; 119(12). PMID: 22160384    Free PMC article.
Highly Cited.
Chimeric antibody receptors (CARs): driving T-cell specificity to enhance anti-tumor immunity.
Partow Kebriaei, Susan S Kelly, +5 authors, Laurence J N Cooper.
Front Biosci (Schol Ed), 2011 Dec 29; 4(2). PMID: 22202074    Free PMC article.
Review.
Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies.
L A Marr, D E Gilham, J D M Campbell, A R Fraser.
Clin Exp Immunol, 2012 Jan 13; 167(2). PMID: 22235997    Free PMC article.
Review.
Armed and accurate: engineering cytotoxic T cells for eradication of leukemia.
Marko Radic.
BMC Biotechnol, 2012 Feb 10; 12. PMID: 22316161    Free PMC article.
Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection.
Manfred Lehner, Gabriel Götz, +11 authors, Wolfgang Holter.
PLoS One, 2012 Feb 23; 7(2). PMID: 22355347    Free PMC article.
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells.
Y Miyahara, M Khattar, +6 authors, S M Stepkowski.
Am J Transplant, 2012 Mar 17; 12(6). PMID: 22420295    Free PMC article.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
A new cellular weapon to kill leukaemic B-cells.
Mohamed-Rachid Boulassel.
Sultan Qaboos Univ Med J, 2012 May 02; 12(2). PMID: 22548131    Free PMC article.
Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF.
Paul Spear, Amorette Barber, Agnieszka Rynda-Apple, Charles L Sentman.
J Immunol, 2012 May 16; 188(12). PMID: 22586039    Free PMC article.
Passive immunotherapeutic strategies for the treatment of malignant gliomas.
Daniel T Nagasawa, Christina Fong, +4 authors, Isaac Yang.
Neurosurg Clin N Am, 2012 Jul 04; 23(3). PMID: 22748660    Free PMC article.
Review.
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.
Tong Zhang, Ming-Ru Wu, Charles L Sentman.
J Immunol, 2012 Aug 02; 189(5). PMID: 22851709    Free PMC article.
Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.
Seogkyoung Kong, Sadhak Sengupta, +9 authors, Prakash Sampath.
Clin Cancer Res, 2012 Sep 12; 18(21). PMID: 22966020    Free PMC article.
Advances in the development of cancer immunotherapies.
Jianjun Gao, Chantale Bernatchez, +2 authors, Patrick Hwu.
Trends Immunol, 2012 Oct 04; 34(2). PMID: 23031830    Free PMC article.
Review.
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.
Xiuli Wang, Araceli Naranjo, +8 authors, Michael C Jensen.
J Immunother, 2012 Oct 24; 35(9). PMID: 23090078    Free PMC article.
The past, present, and future of adoptive T cell therapy.
Donghoon Choi, Tai-Gyu Kim, Young Chul Sung.
Immune Netw, 2012 Oct 24; 12(4). PMID: 23091437    Free PMC article.
CARs in chronic lymphocytic leukemia -- ready to drive.
Chitra Hosing, Partow Kebriaei, +3 authors, Elizabeth Shpall.
Curr Hematol Malig Rep, 2012 Dec 12; 8(1). PMID: 23225251    Free PMC article.
Review.
Novel cellular therapies for leukemia: CAR-modified T cells targeted to the CD19 antigen.
Renier J Brentjens, Kevin J Curran.
Hematology Am Soc Hematol Educ Program, 2012 Dec 13; 2012. PMID: 23233573    Free PMC article.
Review.
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells.
Christopher C Kloss, Maud Condomines, +2 authors, Michel Sadelain.
Nat Biotechnol, 2012 Dec 18; 31(1). PMID: 23242161    Free PMC article.
Highly Cited.
How do CARs work?: Early insights from recent clinical studies targeting CD19.
Marco L Davila, Renier Brentjens, +2 authors, Michel Sadelain.
Oncoimmunology, 2012 Dec 25; 1(9). PMID: 23264903    Free PMC article.
Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation.
Mohamed-Rachid Boulassel, Ahmed Galal.
Sultan Qaboos Univ Med J, 2012 Dec 28; 12(3). PMID: 23269948    Free PMC article.
Developing strategies in the immunotherapy of leukemias.
Jason B Brayer, Javier Pinilla-Ibarz.
Cancer Control, 2013 Jan 11; 20(1). PMID: 23302907    Free PMC article.
Review.
Clinical-scale derivation of natural killer cells from human pluripotent stem cells for cancer therapy.
David A Knorr, Zhenya Ni, +5 authors, Dan S Kaufman.
Stem Cells Transl Med, 2013 Mar 22; 2(4). PMID: 23515118    Free PMC article.
Highly Cited.
CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma.
Lawrence G Lum, Archana Thakur, +13 authors, Voravit Ratanatharathorn.
Biol Blood Marrow Transplant, 2013 Mar 27; 19(6). PMID: 23529012    Free PMC article.
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.
James N Kochenderfer, Steven A Rosenberg.
Nat Rev Clin Oncol, 2013 Apr 03; 10(5). PMID: 23546520    Free PMC article.
Highly Cited. Review.
The basic principles of chimeric antigen receptor design.
Michel Sadelain, Renier Brentjens, Isabelle Rivière.
Cancer Discov, 2013 Apr 04; 3(4). PMID: 23550147    Free PMC article.
Highly Cited. Review.
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.
Himadri Mukhopadhyay, Shaun-Paul Cordoba, +2 authors, Omer Dushek.
PLoS Comput Biol, 2013 Apr 05; 9(3). PMID: 23555234    Free PMC article.
NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors.
Paul Spear, Amorette Barber, Agnieszka Rynda-Apple, Charles L Sentman.
Immunol Cell Biol, 2013 May 01; 91(6). PMID: 23628805    Free PMC article.
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia.
Eric Tran, Dhanalakshmi Chinnasamy, +4 authors, Steven A Rosenberg.
J Exp Med, 2013 May 29; 210(6). PMID: 23712432    Free PMC article.
Highly Cited.
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors.
Paul Spear, Amorette Barber, Charles L Sentman.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734311    Free PMC article.
Altering cell death pathways as an approach to cure HIV infection.
A D Badley, A Sainski, F Wightman, S R Lewin.
Cell Death Dis, 2013 Jul 13; 4. PMID: 23846220    Free PMC article.
Review.
Mesothelin-targeted immunotherapies for malignant pleural mesothelioma.
Jonathan Villena-Vargas, Prasad S Adusumilli.
Ann Cardiothorac Surg, 2013 Aug 27; 1(4). PMID: 23977538    Free PMC article.
Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibition.
Serena K Perna, Daria Pagliara, +4 authors, Gianpietro Dotti.
Clin Cancer Res, 2013 Oct 08; 20(1). PMID: 24097874    Free PMC article.
New approaches to manipulate minimal residual disease after allogeneic stem cell transplantation.
Lindsay Am Rein, Anthony D Sung, David A Rizzieri.
Int J Hematol Oncol, 2013 Dec 05; 2(1). PMID: 24303095    Free PMC article.
A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19.
Harjeet Singh, Helen Huls, Partow Kebriaei, Laurence J N Cooper.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329797    Free PMC article.
Review.
T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo.
Claudia Geldres, Barbara Savoldo, +8 authors, Gianpietro Dotti.
Clin Cancer Res, 2013 Dec 18; 20(4). PMID: 24334762    Free PMC article.
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.
Victor D Fedorov, Maria Themeli, Michel Sadelain.
Sci Transl Med, 2013 Dec 18; 5(215). PMID: 24337479    Free PMC article.
Highly Cited.
Hunting for clinical translation with innate-like immune cells and their receptors.
W Scheper, C Gründer, +2 authors, J Kuball.
Leukemia, 2013 Dec 19; 28(6). PMID: 24345790
Review.
Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo.
Evripidis Lanitis, Mathilde Poussin, +4 authors, Daniel J Powell.
Cancer Immunol Res, 2014 Jan 11; 1(1). PMID: 24409448    Free PMC article.
Highly Cited.
Chronic lymphocytic leukemia: inception to cure: are we there?
Deepesh P Lad, Pankaj Malhotra, Subhash Varma.
Indian J Hematol Blood Transfus, 2014 Jan 16; 29(1). PMID: 24426325    Free PMC article.
Review.
Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice.
Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja, Magnus Essand.
BMC Cancer, 2014 Jan 21; 14. PMID: 24438073    Free PMC article.
Rise of iPSCs as a cell source for adoptive immunotherapy.
Atsutaka Minagawa, Shin Kaneko.
Hum Cell, 2014 Feb 11; 27(2). PMID: 24510519
Review.
Primer on tumor immunology and cancer immunotherapy.
Timothy J Harris, Charles G Drake.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829749    Free PMC article.
Review.
Clinical application of adoptive T cell therapy in solid tumors.
Yi-Wen Zang, Xiao-Dong Gu, Jian-Bin Xiang, Zong-You Chen.
Med Sci Monit, 2014 Jun 11; 20. PMID: 24912947    Free PMC article.
Review.
Synthetic biology for therapeutic applications.
Zhanar Abil, Xiong Xiong, Huimin Zhao.
Mol Pharm, 2014 Aug 08; 12(2). PMID: 25098838    Free PMC article.
Review.
Phenotypic models of T cell activation.
Melissa Lever, Philip K Maini, P Anton van der Merwe, Omer Dushek.
Nat Rev Immunol, 2014 Aug 26; 14(9). PMID: 25145757
Review.
T-cell immunotherapy: looking forward.
Jacqueline Corrigan-Curay, Hans-Peter Kiem, +23 authors, Donald B Kohn.
Mol Ther, 2014 Sep 05; 22(9). PMID: 25186558    Free PMC article.
Targeting CD8+ T-cell tolerance for cancer immunotherapy.
Stephanie R Jackson, Jinyun Yuan, Ryan M Teague.
Immunotherapy, 2014 Oct 08; 6(7). PMID: 25290416    Free PMC article.
Review.
Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis.
Fu-Nan Cho, Tsung-Hsien Chang, +9 authors, Yu-Hsiang Chang.
PLoS One, 2014 Oct 15; 9(10). PMID: 25313995    Free PMC article.
Are natural killer cells superior CAR drivers?
Hans Klingemann.
Oncoimmunology, 2014 Oct 24; 3. PMID: 25340009    Free PMC article.
Highly Cited.
One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism.
Lee Kim Swee, Sebastian Lourido, +2 authors, Hidde L Ploegh.
ACS Chem Biol, 2014 Nov 02; 10(2). PMID: 25360987    Free PMC article.
Matrix-specific anchors: a new concept for targeted delivery and retention of therapeutic cells.
Andrzej Steplewski, Jolanta Fertala, +2 authors, Andrzej Fertala.
Tissue Eng Part A, 2014 Dec 02; 21(7-8). PMID: 25435302    Free PMC article.
Novel immunotherapies for hematologic malignancies.
Michelle H Nelson, Chrystal M Paulos.
Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273    Free PMC article.
Review.
Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor.
H Singh, J S E Moyes, M H Huls, L J N Cooper.
Cancer Gene Ther, 2015 Jan 17; 22(2). PMID: 25591810
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New cell sources for T cell engineering and adoptive immunotherapy.
Maria Themeli, Isabelle Rivière, Michel Sadelain.
Cell Stem Cell, 2015 Apr 07; 16(4). PMID: 25842976    Free PMC article.
Review.
Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases.
Steven C Katz, Rachel A Burga, +11 authors, Richard P Junghans.
Clin Cancer Res, 2015 Apr 09; 21(14). PMID: 25850950    Free PMC article.
Highly Cited.
Immunotherapy for hepatocellular carcinoma: From basic research to clinical use.
Yu-Peng Hong, Zi-Duo Li, Pankaj Prasoon, Qi Zhang.
World J Hepatol, 2015 May 09; 7(7). PMID: 25954480    Free PMC article.
Review.
Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors.
ZeNan L Chang, Pamela A Silver, Yvonne Y Chen.
J Transl Med, 2015 May 21; 13. PMID: 25990251    Free PMC article.
Challenges and future perspectives of T cell immunotherapy in cancer.
Maria Teresa P de Aquino, Anshu Malhotra, Manoj K Mishra, Anil Shanker.
Immunol Lett, 2015 Jun 23; 166(2). PMID: 26096822    Free PMC article.
Review.
The pharmacology of second-generation chimeric antigen receptors.
Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain.
Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802    Free PMC article.
Highly Cited. Review.
Genetic instability in the tumor microenvironment: a new look at an old neighbor.
Antonio Palumbo, Nathalia de Oliveira Meireles Da Costa, +2 authors, Luiz Eurico Nasciutti.
Mol Cancer, 2015 Aug 01; 14. PMID: 26227631    Free PMC article.
Review.
A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing.
Malvina Prapa, Sara Caldrer, +9 authors, Massimo Dominici.
Oncotarget, 2015 Aug 25; 6(28). PMID: 26298772    Free PMC article.
CAR therapy: the CD19 paradigm.
Michel Sadelain.
J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325036    Free PMC article.
Highly Cited. Review.
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors.
Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas.
World J Stem Cells, 2015 Sep 04; 7(7). PMID: 26328018    Free PMC article.
Review.
Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor.
Keith Schutsky, D Gang Song, +5 authors, Daniel J Powell.
Oncotarget, 2015 Sep 12; 6(30). PMID: 26359629    Free PMC article.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Zeguo Zhao, Maud Condomines, +5 authors, Michel Sadelain.
Cancer Cell, 2015 Oct 16; 28(4). PMID: 26461090    Free PMC article.
Highly Cited.
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
Rosalba Camicia, Hans C Winkler, Paul O Hassa.
Mol Cancer, 2015 Dec 15; 14. PMID: 26654227    Free PMC article.
Review.
Computational selection of antibody-drug conjugate targets for breast cancer.
François Fauteux, Jennifer J Hill, +4 authors, Maureen O'Connor-McCourt.
Oncotarget, 2015 Dec 25; 7(3). PMID: 26700623    Free PMC article.
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.
Kole T Roybal, Levi J Rupp, +4 authors, Wendell A Lim.
Cell, 2016 Feb 03; 164(4). PMID: 26830879    Free PMC article.
Highly Cited.
Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects.
Yelei Guo, Yao Wang, Weidong Han.
J Immunol Res, 2016 Mar 22; 2016. PMID: 26998495    Free PMC article.
Review.
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor.
Katherine G MacDonald, Romy E Hoeppli, +5 authors, Megan K Levings.
J Clin Invest, 2016 Mar 22; 126(4). PMID: 26999600    Free PMC article.
Highly Cited.
Cancer Immunotherapy for Gliomas: Overview and Future Directions.
Naoya Hashimoto.
Neurol Med Chir (Tokyo), 2016 Apr 19; 56(7). PMID: 27087194    Free PMC article.
Review.
Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.
K Roellecke, E L Virts, +11 authors, H Hanenberg.
Gene Ther, 2016 Apr 20; 23(7). PMID: 27092941
Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor.
Agnes Shuk-Yee Lo, Chen Xu, Akikazu Murakami, Wayne A Marasco.
Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119093    Free PMC article.
Chimeric antigen receptor-engineered T cells as oncolytic virus carriers.
Heather VanSeggelen, Daniela Gm Tantalo, +2 authors, Jonathan L Bramson.
Mol Ther Oncolytics, 2015 Jan 01; 2. PMID: 27119109    Free PMC article.
Strategies to genetically engineer T cells for cancer immunotherapy.
Timothy T Spear, Kaoru Nagato, Michael I Nishimura.
Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532    Free PMC article.
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Opportunities in immunotherapy of ovarian cancer.
G Coukos, J Tanyi, L E Kandalaft.
Ann Oncol, 2016 May 04; 27 Suppl 1. PMID: 27141063    Free PMC article.
Review.
Biology and clinical application of CAR T cells for B cell malignancies.
Marco L Davila, Michel Sadelain.
Int J Hematol, 2016 Jun 06; 104(1). PMID: 27262700    Free PMC article.
Review.
A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.
Nicholas Paul Casey, Hiroshi Fujiwara, +5 authors, Masaki Yasukawa.
PLoS One, 2016 Jun 09; 11(6). PMID: 27271876    Free PMC article.
Chimeric antigen receptors: driving immunology towards synthetic biology.
Michel Sadelain.
Curr Opin Immunol, 2016 Jul 04; 41. PMID: 27372731    Free PMC article.
Review.
Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Jessica Dobbins, Etienne Gagnon, +4 authors, Kai W Wucherpfennig.
Sci Signal, 2016 Jul 28; 9(438). PMID: 27460989    Free PMC article.
Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.
Alexander K Tsai, Eduardo Davila.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467930    Free PMC article.
Review.
Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.
Melissa Lever, Hong-Sheng Lim, +6 authors, Omer Dushek.
Proc Natl Acad Sci U S A, 2016 Oct 30; 113(43). PMID: 27702900    Free PMC article.
Immunoproteasome deficiency in non-small cell lung cancer and its relevance to immunotherapy.
Juergen Kast.
J Thorac Dis, 2016 Oct 18; 8(9). PMID: 27747070    Free PMC article.
Combining Cell and Gene Therapy in an Effort to Eradicate HIV.
Thor A Wagner.
AIDS Patient Care STDS, 2016 Dec 03; 30(12). PMID: 27905840    Free PMC article.
Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research.
Kanako Inoo, Ryo Inagaki, +4 authors, Naoki Okada.
Mol Ther Oncolytics, 2016 Dec 03; 3. PMID: 27909701    Free PMC article.
Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia.
Noelle V Frey, David L Porter.
Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913530    Free PMC article.
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Regulatory T cells: tolerance induction in solid organ transplantation.
T Vaikunthanathan, N Safinia, +2 authors, G Lombardi.
Clin Exp Immunol, 2017 Apr 20; 189(2). PMID: 28422316    Free PMC article.
Review.
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective.
Isabelle Rivière, Michel Sadelain.
Mol Ther, 2017 May 01; 25(5). PMID: 28456379    Free PMC article.
Review.
Engineering Chimeric Antigen Receptors.
S V Kulemzin, V V Kuznetsova, +2 authors, A A Gorchakov.
Acta Naturae, 2017 May 04; 9(1). PMID: 28461969    Free PMC article.
FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical Relevance.
Sara Caratelli, Tommaso Sconocchia, +9 authors, Giuseppe Sconocchia.
Front Immunol, 2017 May 13; 8. PMID: 28496440    Free PMC article.
Review.
Therapeutic T cell engineering.
Michel Sadelain, Isabelle Rivière, Stanley Riddell.
Nature, 2017 May 26; 545(7655). PMID: 28541315    Free PMC article.
Highly Cited. Review.
Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T-cell malignancies.
Liyanage P Perera, Meili Zhang, +5 authors, Pin-Yu Perera.
Am J Hematol, 2017 May 26; 92(9). PMID: 28543380    Free PMC article.
Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models.
Melinda Mata, Claudia Gerken, +3 authors, Stephen Gottschalk.
Cancer Discov, 2017 Aug 13; 7(11). PMID: 28801306    Free PMC article.
Chimeric antigen receptor T-cell therapies for lymphoma.
Jennifer N Brudno, James N Kochenderfer.
Nat Rev Clin Oncol, 2017 Sep 01; 15(1). PMID: 28857075
Highly Cited. Review.
CAR-T cell therapy in ovarian cancer: from the bench to the bedside.
Xinxin Zhu, Han Cai, +2 authors, Jinghe Lang.
Oncotarget, 2017 Oct 04; 8(38). PMID: 28969098    Free PMC article.
Review.
Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model.
Elham Pishali Bejestani, Marc Cartellieri, +14 authors, Malte von Bonin.
Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123951    Free PMC article.
Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors.
Erhao Zhang, Jieyi Gu, Hanmei Xu.
Mol Cancer, 2018 Jan 14; 17(1). PMID: 29329591    Free PMC article.
Review.
Current state and future prospects of immunotherapy for glioma.
Neha Kamran, Mahmoud S Alghamri, +6 authors, Maria G Castro.
Immunotherapy, 2018 Feb 10; 10(4). PMID: 29421984    Free PMC article.
Review.
Quarter Century of Anti-HIV CAR T Cells.
Thor A Wagner.
Curr HIV/AIDS Rep, 2018 Mar 04; 15(2). PMID: 29500712    Free PMC article.
Review.
Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells.
Wei Xiong, Yuhui Chen, +8 authors, Dongfang Liu.
Mol Ther, 2018 Mar 06; 26(4). PMID: 29503199    Free PMC article.
CD19 CAR-T cell therapy for relapsed/refractory acute lymphoblastic leukemia: factors affecting toxicities and long-term efficacies.
Li-Na Zhang, Yongping Song, Delong Liu.
J Hematol Oncol, 2018 Mar 17; 11(1). PMID: 29544528    Free PMC article.
The development of CAR design for tumor CAR-T cell therapy.
Dandan Xu, Guoliang Jin, +5 authors, Junnian Zheng.
Oncotarget, 2018 Mar 24; 9(17). PMID: 29568411    Free PMC article.
Review.
Versatile CAR T-cells for cancer immunotherapy.
Fuliang Chu, Jingjing Cao, Sattva S Neelalpu.
Contemp Oncol (Pozn), 2018 Apr 10; 22(1A). PMID: 29628798    Free PMC article.
Review.
PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89Zr-Oxine.
Michael R Weist, Renate Starr, +10 authors, John E Shively.
J Nucl Med, 2018 May 08; 59(10). PMID: 29728514    Free PMC article.
Are ovarian cancer stem cells the target for innovative immunotherapy?
Liang Wang, Tianmin Xu, Manhua Cui.
Onco Targets Ther, 2018 May 22; 11. PMID: 29780254    Free PMC article.
Review.
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.
Concetta Quintarelli, Domenico Orlando, +14 authors, Ignazio Caruana.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872565    Free PMC article.
Ovarian Cancer Immunotherapy: Preclinical Models and Emerging Therapeutics.
Curtis W McCloskey, Galaxia M Rodriguez, Kristianne J C Galpin, Barbara C Vanderhyden.
Cancers (Basel), 2018 Jul 28; 10(8). PMID: 30049987    Free PMC article.
Review.
Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice.
Yunsik Choi, Sanghyuk Lee, +3 authors, Charles Lee.
Exp Mol Med, 2018 Aug 10; 50(8). PMID: 30089794    Free PMC article.
Review.
Immunotherapy in Prostate Cancer: Teaching an Old Dog New Tricks.
Michael C Comiskey, Matthew C Dallos, Charles G Drake.
Curr Oncol Rep, 2018 Aug 19; 20(9). PMID: 30120592
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Conventional CARs versus modular CARs.
Anja Feldmann, Claudia Arndt, +3 authors, Michael P Bachmann.
Cancer Immunol Immunother, 2019 Sep 23; 68(10). PMID: 31542798    Free PMC article.
Review.
En masse discovery of anti-cancer human monoclonal antibodies by de novo assembly of immunoglobulin sequences from transcriptomes and genome sequences of cancer tissues.
Peng Zhang, Hung-Yen Chou, +2 authors, Yang Liu.
Cell Mol Immunol, 2019 Sep 29; 16(12). PMID: 31562388    Free PMC article.
CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart.
Ronald J Vagnozzi, Anne Katrine Z Johansen, Jeffery D Molkentin.
Mol Ther, 2019 Oct 06; 27(11). PMID: 31585799    Free PMC article.
Advances Of Chimeric Antigen Receptor T Cell Therapy In Ovarian Cancer.
Wenying Yan, Hongmei Hu, Biao Tang.
Onco Targets Ther, 2019 Nov 07; 12. PMID: 31686857    Free PMC article.
Ovarian cancer: Current status and strategies for improving therapeutic outcomes.
Ashwin Chandra, Cima Pius, +4 authors, Riyaz Basha.
Cancer Med, 2019 Sep 29; 8(16). PMID: 31560828    Free PMC article.
Review.
Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies.
Jiali Cheng, Lei Zhao, +5 authors, Jianfeng Zhou.
Front Oncol, 2019 Dec 12; 9. PMID: 31824840    Free PMC article.
Review.
Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy.
Ryan D Salinas, Joseph S Durgin, Donald M O'Rourke.
CNS Drugs, 2020 Jan 10; 34(2). PMID: 31916100
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The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19.
Peter Braendstrup, Bruce L Levine, Marco Ruella.
Cytotherapy, 2020 Feb 06; 22(2). PMID: 32014447    Free PMC article.
Review.
T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance.
Smita S Chandran, Christopher A Klebanoff.
Immunol Rev, 2019 Jul 30; 290(1). PMID: 31355495    Free PMC article.
Highly Cited. Review.
An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells.
Justyna Jureczek, Ralf Bergmann, +7 authors, Anja Feldmann.
Sci Rep, 2019 Jul 25; 9(1). PMID: 31332252    Free PMC article.
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells.
Michelle L Saetersmoen, Quirin Hammer, +2 authors, Karl-Johan Malmberg.
Semin Immunopathol, 2018 Oct 27; 41(1). PMID: 30361801
Review.
Advances in Developing CAR T-Cell Therapy for HIV Cure.
Jinxin Qi, Chengchao Ding, Xian Jiang, Yong Gao.
Front Immunol, 2020 Mar 27; 11. PMID: 32210965    Free PMC article.
Review.
Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment.
Heidi Harjunpää, Marc Llort Asens, Carla Guenther, Susanna C Fagerholm.
Front Immunol, 2019 Jun 25; 10. PMID: 31231358    Free PMC article.
Highly Cited. Review.
Is TCR/pMHC Affinity a Good Estimate of the T-cell Response? An Answer Based on Predictions From 12 Phenotypic Models.
Jesús Gálvez, Juan J Gálvez, Pilar García-Peñarrubia.
Front Immunol, 2019 Mar 20; 10. PMID: 30886616    Free PMC article.
Applications and explorations of CRISPR/Cas9 in CAR T-cell therapy.
Chenggong Li, Heng Mei, Yu Hu.
Brief Funct Genomics, 2020 Jan 18; 19(3). PMID: 31950135    Free PMC article.
Review.
Chimeric antigen receptor signaling: Functional consequences and design implications.
S E Lindner, S M Johnson, C E Brown, L D Wang.
Sci Adv, 2020 Jul 09; 6(21). PMID: 32637585    Free PMC article.
Review.
[Construction of CD19-CAR retroviral vector and modification of its transduction of human T-lymphocytes].
Yang Wang, Gusheng Tang, +9 authors, Jianmin Yang.
Zhonghua Xue Ye Xue Za Zhi, 2015 Apr 29; 36(4). PMID: 25916298    Free PMC article.
[Cytotoxity of pomalidomide combined CAR-T cell for multiple myeloma cell RPMI8226 and U266].
Lei Wang, Shuting Zhang, Jianfeng Ou, Hai Bai.
Zhonghua Xue Ye Xue Za Zhi, 2015 Jul 03; 36(6). PMID: 26134016    Free PMC article.
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects.
Hongyi Li, Yang Yang, +3 authors, Xia Zhao.
Signal Transduct Target Ther, 2020 Apr 17; 5(1). PMID: 32296011    Free PMC article.
Review.
CAR-T design: Elements and their synergistic function.
Jayapriya Jayaraman, Michael P Mellody, +5 authors, Weian Zhao.
EBioMedicine, 2020 Aug 03; 58. PMID: 32739874    Free PMC article.
Review.
Chimeric Antigen Receptor Therapy.
Carl H June, Michel Sadelain.
N Engl J Med, 2018 Jul 05; 379(1). PMID: 29972754    Free PMC article.
Highly Cited. Review.
Current Clinical Evidence and Potential Solutions to Increase Benefit of CAR T-Cell Therapy for Patients with Solid Tumors.
Marion Alcantara, Pauline Du Rusquec, Emanuela Romano.
Oncoimmunology, 2020 Sep 17; 9(1). PMID: 32934880    Free PMC article.
Review.
Chimeric Antigen Receptor T-Cell Therapy: A Beacon of Hope in the Fight Against Cancer.
Syed Maaz Tariq, Syed Ali Haider, +4 authors, Anum Kamal.
Cureus, 2019 Jan 08; 10(10). PMID: 30613448    Free PMC article.
Review.
Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor.
Ryosuke Uchibori, Takeshi Teruya, +6 authors, Keiya Ozawa.
Mol Ther Oncolytics, 2019 Jan 22; 12. PMID: 30662937    Free PMC article.
Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy.
Agathe Dubuisson, Olivier Micheau.
Antibodies (Basel), 2017 Oct 25; 6(4). PMID: 31548531    Free PMC article.
Review.
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.
Blake J Rust, Leslie S Kean, +13 authors, Christopher W Peterson.
Blood, 2020 Jul 03; 136(15). PMID: 32614969    Free PMC article.
Hepatocellular Carcinoma-The Influence of Immunoanatomy and the Role of Immunotherapy.
Keyur Patel, Ryan Lamm, +2 authors, Ashesh P Shah.
Int J Mol Sci, 2020 Sep 19; 21(18). PMID: 32942580    Free PMC article.
Review.
Will Next-Generation Immunotherapy Overcome the Intrinsic Diversity and Low Immunogenicity of Sarcomas to Improve Clinical Benefit?
Hui Yi Chew, Victor Chan, Fiona Simpson, Riccardo Dolcetti.
Cancers (Basel), 2020 Nov 20; 12(11). PMID: 33207697    Free PMC article.
Review.
Adoptive cell therapy: genetic modification to redirect effector cell specificity.
Richard A Morgan, Mark E Dudley, Steven A Rosenberg.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693844    Free PMC article.
Review.
Current Immunotherapy Approaches in Non-Hodgkin Lymphomas.
Robert Pytlik, Kamila Polgarova, Jana Karolova, Pavel Klener.
Vaccines (Basel), 2020 Dec 03; 8(4). PMID: 33260966    Free PMC article.
Review.
Noninvasive Imaging of Cancer Immunotherapy.
Omar Abousaway, Taha Rakhshandehroo, +2 authors, Mohammad Rashidian.
Nanotheranostics, 2021 Jan 05; 5(1). PMID: 33391977    Free PMC article.
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Current and future immunotherapy approaches in ovarian cancer.
Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk.
Ann Transl Med, 2021 Jan 26; 8(24). PMID: 33490226    Free PMC article.
Review.
Proceedings From the First International Workshop at Sidra Medicine: "Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development", 15th-16th February 2019, Doha, Qatar.
Bella Guerrouahen, Muhammad Elnaggar, +15 authors, EICCI Faculty Group.
Front Immunol, 2021 Feb 16; 11. PMID: 33584653    Free PMC article.
CAR T Cell Therapy in Pancreaticobiliary Cancers: a Focused Review of Clinical Data.
Muhammad Yasir Anwar, Grant R Williams, Ravi K Paluri.
J Gastrointest Cancer, 2020 Jul 24; 52(1). PMID: 32700185
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BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor.
Jiaxing Tang, Yan Zou, +6 authors, Xuekai Zhu.
Front Pharmacol, 2021 Mar 30; 12. PMID: 33776765    Free PMC article.
Novel approaches to enhance the specificity and safety of engineered T cells.
Victor D Fedorov, Michel Sadelain, Christopher C Kloss.
Cancer J, 2014 Mar 29; 20(2). PMID: 24667964    Free PMC article.
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy.
Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki.
Cells, 2021 Jun 03; 10(5). PMID: 34065010    Free PMC article.
Review.
Theranostic cells: emerging clinical applications of synthetic biology.
Monica P McNerney, Kailyn E Doiron, +2 authors, Pamela A Silver.
Nat Rev Genet, 2021 Jul 09; 22(11). PMID: 34234299    Free PMC article.
Review.
Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope.
Alejandrina Hernández-López, Mario A Téllez-González, Paul Mondragón-Terán, Angélica Meneses-Acosta.
Front Pharmacol, 2021 Sep 08; 12. PMID: 34489708    Free PMC article.
Review.
Chimeric Antigen Receptor T-Cell Therapy: The Light of Day for Osteosarcoma.
Zili Lin, Ziyi Wu, Wei Luo.
Cancers (Basel), 2021 Sep 11; 13(17). PMID: 34503279    Free PMC article.
Review.
Chimeric antigen receptor (CAR) immunotherapy: basic principles, current advances, and future prospects in neuro-oncology.
Hyeon Joo Yoo, Biyan Nathanael Harapan.
Immunol Res, 2021 Sep 24; 69(6). PMID: 34554405    Free PMC article.
Review.
A Novel Treatment for Ewing's Sarcoma: Chimeric Antigen Receptor-T Cell Therapy.
Zili Lin, Ziyi Wu, Wei Luo.
Front Immunol, 2021 Sep 28; 12. PMID: 34566963    Free PMC article.
Review.
Advances in Universal CAR-T Cell Therapy.
Haolong Lin, Jiali Cheng, +2 authors, Li Zhu.
Front Immunol, 2021 Oct 26; 12. PMID: 34691052    Free PMC article.
Review.
Effective chimeric antigen receptor T cells against SARS-CoV-2.
Xueyang Guo, Alexandra Kazanova, +2 authors, Christopher E Rudd.
iScience, 2021 Oct 26; 24(11). PMID: 34693218    Free PMC article.
Next Generation of Cancer Treatments: Chimeric Antigen Receptor T-Cell Therapy and Its Related Toxicities: A Review for Perioperative Physicians.
Germán Echeverry, Gregory W Fischer, Elena Mead.
Anesth Analg, 2019 May 28; 129(2). PMID: 31124841    Free PMC article.
Review.
Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
Yasmin R Mohseni, Adeel Saleem, +13 authors, Giovanna Lombardi.
Eur J Immunol, 2021 Jul 29; 51(10). PMID: 34320225    Free PMC article.
Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress.
Hendrik Setia Budi, Firdaus Nuri Ahmad, +6 authors, Faroogh Marofi.
Stem Cell Res Ther, 2022 Jan 31; 13(1). PMID: 35093187    Free PMC article.
Review.
Fluctuations in T cell receptor and pMHC interactions regulate T cell activation.
Joseph R Egan, Enas Abu-Shah, +2 authors, Ben D MacArthur.
J R Soc Interface, 2022 Feb 10; 19(187). PMID: 35135295    Free PMC article.
Novel Cellular Therapies for Hepatocellular Carcinoma.
Harriet Roddy, Tim Meyer, Claire Roddie.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158772    Free PMC article.
Review.
Genetic Modification of T Cells for the Immunotherapy of Cancer.
Suzanne Quinn, Natasha Lenart, +3 authors, Michael I Nishimura.
Vaccines (Basel), 2022 Mar 27; 10(3). PMID: 35335089    Free PMC article.
Review.
c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and in vivo.
Xiaochen Huang, Jiaojiao Guo, +5 authors, Zhenqing Feng.
J Biomed Res, 2022 Apr 12; 36(1). PMID: 35403606    Free PMC article.