Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

Michael C Milone ¹, Jonathan D Fish , Carmine Carpenito , Richard G Carroll , Gwendolyn K Binder , David Teachey , Minu Samanta , Mehdi Lakhal , Brian Gloss , Gwenn Danet-Desnoyers , Dario Campana , James L Riley , Stephan A Grupp , Carl H June

Affiliations

¹ Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-5160, USA. milone@mail.med.upenn.edu

PMID: 19384291
48 References
506 citations

Abstract

Persistence of T cells engineered with chimeric antigen receptors (CARs) has been a major barrier to use of these cells for molecularly targeted adoptive immunotherapy. To address this issue, we created a series of CARs that contain the T cell receptor-zeta (TCR-zeta) signal transduction domain with the CD28 and/or CD137 (4-1BB) intracellular domains in tandem. After short-term expansion, primary human T cells were subjected to lentiviral gene transfer, resulting in large numbers of cells with >85% CAR expression. In an immunodeficient mouse xenograft model of primary human pre-B-cell acute lymphoblastic leukemia, human T cells expressing anti-CD19 CARs containing CD137 exhibited the greatest antileukemic efficacy and prolonged (>6 months) survival in vivo, and were significantly more effective than cells expressing CARs containing TCR-zeta alone or CD28-zeta signaling receptors. We uncovered a previously unrecognized, antigen-independent effect of CARs expressing the CD137 cytoplasmic domain that likely contributes to the enhanced antileukemic efficacy and survival in tumor bearing mice. Furthermore, our studies revealed significant discrepancies between in vitro and in vivo surrogate measures of CAR efficacy. Together these results suggest that incorporation of the CD137 signaling domain in CARs should improve the persistence of CARs in the hematologic malignancies and hence maximize their antitumor activity.

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Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Michael Hudecek, Maria-Teresa Lupo-Stanghellini, +4 authors, Stanley R Riddell. less Clin Cancer Res, 2013 Apr 27; 19(12). PMID: 23620405 Free PMC article. Highly Cited.
Harnessing autophagy for cell fate control gene therapy. Tania C Felizardo, Jason Foley, +4 authors, Daniel H Fowler. less Autophagy, 2013 May 02; 9(7). PMID: 23633667 Free PMC article.
The immunogenicity of virus-derived 2A sequences in immunocompetent individuals. C Arber, H Abhyankar, +4 authors, B Savoldo. less Gene Ther, 2013 May 24; 20(9). PMID: 23698740 Free PMC article.
Young T Cells Age During a Redirected Anti-Tumor Attack: Chimeric Antigen Receptor-Provided Dual Costimulation is Half the Battle. Andreas A Hombach, Hinrich Abken. Front Immunol, 2013 Jun 14; 4. PMID: 23761793 Free PMC article.
Chimeric antigen receptor-engineered T cells for cancer immunotherapy: progress and challenges. Ethan Q Han, Xiu-ling Li, +2 authors, Chun-rong Wang, Tian-fang Li, Shuang-yin Han. less J Hematol Oncol, 2013 Jul 09; 6. PMID: 23829929 Free PMC article. Review.
CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models. Tomonori Tsukahara, Ken Ohmine, +13 authors, Keiya Ozawa. less Biochem Biophys Res Commun, 2013 Jul 23; 438(1). PMID: 23872144 Free PMC article.
Gene-engineered T cells for cancer therapy. Michael H Kershaw, Jennifer A Westwood, Phillip K Darcy. Nat Rev Cancer, 2013 Jul 25; 13(8). PMID: 23880905 Highly Cited. Review.
Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia. David M Barrett, Xiaojun Liu, +3 authors, Yangbing Zhao. less Hum Gene Ther, 2013 Jul 26; 24(8). PMID: 23883116 Free PMC article.
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia. Armen Mardiros, Cedric Dos Santos, +14 authors, Stephen J Forman. less Blood, 2013 Sep 14; 122(18). PMID: 24030378 Free PMC article. Highly Cited.
Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. Bryan D Choi, Carter M Suryadevara, +4 authors, John H Sampson. less J Clin Neurosci, 2013 Sep 24; 21(1). PMID: 24054399 Free PMC article.
Mouse models in bone marrow transplantation and adoptive cellular therapy. Caroline Arber, Malcolm K Brenner, Pavan Reddy. Semin Hematol, 2013 Nov 13; 50(2). PMID: 24216170 Free PMC article. Review.
Engineered T cells for cancer treatment. Usanarat Anurathapan, Ann M Leen, Malcolm K Brenner, Juan F Vera. Cytotherapy, 2013 Nov 19; 16(6). PMID: 24239105 Free PMC article. Review.
Chimeric antigen receptor therapy for cancer. David M Barrett, Nathan Singh, +2 authors, David L Porter, Stephan A Grupp, Carl H June. less Annu Rev Med, 2013 Nov 28; 65. PMID: 24274181 Free PMC article. Highly Cited. Review.
Design and development of therapies using chimeric antigen receptor-expressing T cells. Gianpietro Dotti, Stephen Gottschalk, Barbara Savoldo, Malcolm K Brenner. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329793 Free PMC article. Highly Cited. Review.
Hematopoietic stem cells for cancer immunotherapy. Eric Gschweng, Satiro De Oliveira, Donald B Kohn. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329801 Free PMC article. Review.
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. John H Sampson, Bryan D Choi, +12 authors, Laura A Johnson. less Clin Cancer Res, 2013 Dec 20; 20(4). PMID: 24352643 Free PMC article. Highly Cited.
Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma. Lihua E Budde, Carolina Berger, +9 authors, Oliver W Press. less PLoS One, 2013 Dec 21; 8(12). PMID: 24358223 Free PMC article. Highly Cited.
Toxicity management for patients receiving novel T-cell engaging therapies. David M Barrett, David T Teachey, Stephan A Grupp. Curr Opin Pediatr, 2013 Dec 24; 26(1). PMID: 24362408 Free PMC article. Review.
Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo. Evripidis Lanitis, Mathilde Poussin, +4 authors, Daniel J Powell. less Cancer Immunol Res, 2014 Jan 11; 1(1). PMID: 24409448 Free PMC article. Highly Cited.
Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy. David M Barrett, Nathan Singh, +4 authors, Yangbing Zhao. less Cytotherapy, 2014 Jan 21; 16(5). PMID: 24439255 Free PMC article.
Driving CAR-based T-cell therapy to success. Bipulendu Jena, Judy S Moyes, Helen Huls, Laurence J N Cooper. Curr Hematol Malig Rep, 2014 Feb 04; 9(1). PMID: 24488441 Free PMC article. Review.
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Marco L Davila, Isabelle Riviere, +29 authors, Renier Brentjens. less Sci Transl Med, 2014 Feb 21; 6(224). PMID: 24553386 Free PMC article. Highly Cited.
Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Marcela V Maus, Stephan A Grupp, David L Porter, Carl H June. Blood, 2014 Mar 01; 123(17). PMID: 24578504 Free PMC article. Highly Cited. Review.
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells. Saar Gill, Sarah K Tasian, +9 authors, Michael Kalos. less Blood, 2014 Mar 07; 123(15). PMID: 24596416 Free PMC article. Highly Cited.
Managing cytokine release syndrome associated with novel T cell-engaging therapies. Shannon L Maude, David Barrett, David T Teachey, Stephan A Grupp. Cancer J, 2014 Mar 29; 20(2). PMID: 24667956 Free PMC article. Highly Cited. Review.
A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engrafted human T cells. Marc Cartellieri, Stefanie Koristka, +12 authors, Michael P Bachmann. less PLoS One, 2014 Apr 05; 9(4). PMID: 24699869 Free PMC article.
Complementation of antigen-presenting cells to generate T lymphocytes with broad target specificity. Minhtran Charlotte Ngo, Jun Ando, +9 authors, Cliona M Rooney. less J Immunother, 2014 Apr 10; 37(4). PMID: 24714353 Free PMC article.
Cell transfer therapy for cancer: past, present, and future. Xiaoling Qian, Xian Wang, Hongchuan Jin. J Immunol Res, 2014 Apr 18; 2014. PMID: 24741604 Free PMC article. Review.
An allogeneic NK cell line engineered to express chimeric antigen receptors: A novel strategy of cellular immunotherapy against cancer. Cécile Badoual, Pierre-Louis Bastier, +2 authors, Hélène Roussel, Marion Mandavit, Eric Tartour. less Oncoimmunology, 2014 Apr 23; 2(11). PMID: 24753987 Free PMC article.
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Liang-Chuan S Wang, Albert Lo, +11 authors, Steven M Albelda. less Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778279 Free PMC article. Highly Cited.
T cells redirected to interleukin-13Rα2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1. Simone Krebs, Kevin K H Chow, +5 authors, Stephen Gottschalk. less Cytotherapy, 2014 May 21; 16(8). PMID: 24841514 Free PMC article.
Progress and prospects for engineered T cell therapies. Waseem Qasim, Adrian J Thrasher. Br J Haematol, 2014 Jun 18; 166(6). PMID: 24935654 Free PMC article. Review.
Th17 cells in cancer: the ultimate identity crisis. Stefanie R Bailey, Michelle H Nelson, +3 authors, Chrystal M Paulos. less Front Immunol, 2014 Jul 06; 5. PMID: 24987392 Free PMC article. Highly Cited. Review.
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control. Jennifer D Stone, Daniel T Harris, +4 authors, David M Kranz. less Cancer Immunol Immunother, 2014 Aug 02; 63(11). PMID: 25082071 Free PMC article.
Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma. Nathan Singh, Xiaojun Liu, +5 authors, Yangbing Zhao. less Cancer Immunol Res, 2014 Aug 12; 2(11). PMID: 25104548 Free PMC article.
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. James N Kochenderfer, Mark E Dudley, +23 authors, Steven A Rosenberg. less J Clin Oncol, 2014 Aug 27; 33(6). PMID: 25154820 Free PMC article. Highly Cited.
The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. Michael Hudecek, Daniel Sommermeyer, +5 authors, Stanley R Riddell. less Cancer Immunol Res, 2014 Sep 13; 3(2). PMID: 25212991 Free PMC article. Highly Cited.
Toward synthetic biology with engineered T cells: a long journey just begun. Carl H June. Hum Gene Ther, 2014 Sep 23; 25(9). PMID: 25244569 Free PMC article.
PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models. Gaia Zuccolotto, Giulio Fracasso, +8 authors, Antonio Rosato. less PLoS One, 2014 Oct 04; 9(10). PMID: 25279468 Free PMC article.
Enhanced cytotoxicity of natural killer cells following the acquisition of chimeric antigen receptors through trogocytosis. Fu-Nan Cho, Tsung-Hsien Chang, +9 authors, Yu-Hsiang Chang. less PLoS One, 2014 Oct 15; 9(10). PMID: 25313995 Free PMC article.
Chimeric antigen receptor T cells for sustained remissions in leukemia. Shannon L Maude, Noelle Frey, +16 authors, Stephan A Grupp. less N Engl J Med, 2014 Oct 16; 371(16). PMID: 25317870 Free PMC article. Highly Cited.
Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy. Mahesh Jonnalagadda, Armen Mardiros, +10 authors, Christine E Brown. less Mol Ther, 2014 Nov 05; 23(4). PMID: 25366031 Free PMC article.
An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities. Yair Tal, Shlomo Yaakobi, +4 authors, Cyrille J Cohen. less Oncotarget, 2014 Nov 29; 5(21). PMID: 25431955 Free PMC article.
CIMT 2014: Next waves in cancer immunotherapy--report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany. Mustafa Diken, Sebastian Boegel, +6 authors, Sebastian Kreiter. less Hum Vaccin Immunother, 2014 Dec 09; 10(10). PMID: 25483671 Free PMC article.
Clinical application of genetically modified T cells in cancer therapy. Michael H Kershaw, Jennifer A Westwood, Clare Y Slaney, Phillip K Darcy. Clin Transl Immunology, 2014 Dec 17; 3(5). PMID: 25505964 Free PMC article. Review.
Novel immunotherapies for hematologic malignancies. Michelle H Nelson, Chrystal M Paulos. Immunol Rev, 2014 Dec 17; 263(1). PMID: 25510273 Free PMC article. Review.
Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Matthew J Frigault, Jihyun Lee, +16 authors, Carl H June. less Cancer Immunol Res, 2015 Jan 21; 3(4). PMID: 25600436 Free PMC article. Highly Cited.
Designing chimeric antigen receptors to effectively and safely target tumors. Michael C Jensen, Stanley R Riddell. Curr Opin Immunol, 2015 Jan 27; 33. PMID: 25621840 Free PMC article. Highly Cited. Review.
Using gene therapy to manipulate the immune system in the fight against B-cell leukemias. Diana C G Bouhassira, Joshua J Thompson, Marco L Davila. Expert Opin Biol Ther, 2015 Feb 11; 15(3). PMID: 25666545 Free PMC article. Review.
Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells. B L Levine. Cancer Gene Ther, 2015 Feb 14; 22(2). PMID: 25675873 Review.
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Laura A Johnson, John Scholler, +26 authors, Marcela V Maus. less Sci Transl Med, 2015 Feb 20; 7(275). PMID: 25696001 Free PMC article. Highly Cited.
CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia. S S Kenderian, M Ruella, +9 authors, S Gill. less Leukemia, 2015 Feb 28; 29(8). PMID: 25721896 Free PMC article. Highly Cited.
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma. Nabil Ahmed, Vita S Brawley, +23 authors, Stephen Gottschalk. less J Clin Oncol, 2015 Mar 25; 33(15). PMID: 25800760 Free PMC article. Highly Cited.
Chimeric antigen receptor-engineered T cells for the treatment of metastatic prostate cancer. Victoria Hillerdal, Magnus Essand. BioDrugs, 2015 Apr 11; 29(2). PMID: 25859858 Free PMC article. Review.
Engineering T Cells to Functionally Cure HIV-1 Infection. Rachel S Leibman, James L Riley. Mol Ther, 2015 Apr 22; 23(7). PMID: 25896251 Free PMC article. Review.
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Adrienne H Long, Waleed M Haso, +12 authors, Crystal L Mackall. less Nat Med, 2015 May 06; 21(6). PMID: 25939063 Free PMC article. Highly Cited.
Generation of Potent T-cell Immunotherapy for Cancer Using DAP12-Based, Multichain, Chimeric Immunoreceptors. Enxiu Wang, Liang-Chuan Wang, +12 authors, Michael C Milone. less Cancer Immunol Res, 2015 May 06; 3(7). PMID: 25941351 Free PMC article.
CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Shannon L Maude, David T Teachey, David L Porter, Stephan A Grupp. Blood, 2015 May 23; 125(26). PMID: 25999455 Free PMC article. Highly Cited. Review.
Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells. Román Galetto, Celine Lebuhotel, +4 authors, Andrew Scharenberg. less Mol Ther Methods Clin Dev, 2014 Jan 01; 1. PMID: 26015965 Free PMC article.
Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Bettina Weigelin, Elixabet Bolaños, +10 authors, Ignacio Melero. less Proc Natl Acad Sci U S A, 2015 Jun 03; 112(24). PMID: 26034288 Free PMC article.
The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer. Frank Cichocki, Michael R Verneris, +8 authors, Jeffrey S Miller. less Curr Top Microbiol Immunol, 2015 Jun 04; 395. PMID: 26037048 Free PMC article. Review.
Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. Haiying Qin, Monica Cho, +15 authors, Terry J Fry. less Blood, 2015 Jun 05; 126(5). PMID: 26041741 Free PMC article.
Adoptive T-cell therapy for Leukemia. Haven R Garber, Asma Mirza, Elizabeth A Mittendorf, Gheath Alatrash. Mol Cell Ther, 2014 Jan 01; 2. PMID: 26056592 Free PMC article. Review.
A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity. De-Gang Song, Qunrui Ye, +3 authors, Daniel J Powell. less Oncotarget, 2015 Jun 24; 6(25). PMID: 26101914 Free PMC article.
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Heather VanSeggelen, Joanne A Hammill, +6 authors, Jonathan L Bramson. less Mol Ther, 2015 Jul 01; 23(10). PMID: 26122933 Free PMC article.
The pharmacology of second-generation chimeric antigen receptors. Sjoukje J C van der Stegen, Mohamad Hamieh, Michel Sadelain. Nat Rev Drug Discov, 2015 Jul 02; 14(7). PMID: 26129802 Free PMC article. Highly Cited. Review.
Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street. David M Barrett, Stephan A Grupp, Carl H June. J Immunol, 2015 Jul 19; 195(3). PMID: 26188068 Free PMC article. Highly Cited. Review.
Construction of Anti-CD20 Single-Chain Antibody-CD28-CD137-TCRζ Recombinant Genetic Modified T Cells and its Treatment Effect on B Cell Lymphoma. Fei Chen, Chuming Fan, +6 authors, Xun Lai. less Med Sci Monit, 2015 Jul 22; 21. PMID: 26195067 Free PMC article.
Post-autologous transplant maintenance therapies in lymphoid malignancies: are we there yet? N Epperla, T S Fenske, H M Lazarus, M Hamadani. Bone Marrow Transplant, 2015 Aug 19; 50(11). PMID: 26281033 Review.
CAR therapy: the CD19 paradigm. Michel Sadelain. J Clin Invest, 2015 Sep 02; 125(9). PMID: 26325036 Free PMC article. Highly Cited. Review.
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors. Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas. World J Stem Cells, 2015 Sep 04; 7(7). PMID: 26328018 Free PMC article. Review.
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. David L Porter, Wei-Ting Hwang, +15 authors, Carl H June. less Sci Transl Med, 2015 Sep 04; 7(303). PMID: 26333935 Free PMC article. Highly Cited.
Smart CARs engineered for cancer immunotherapy. Saul J Priceman, Stephen J Forman, Christine E Brown. Curr Opin Oncol, 2015 Sep 10; 27(6). PMID: 26352543 Free PMC article. Review.
Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor. Keith Schutsky, D Gang Song, +5 authors, Daniel J Powell. less Oncotarget, 2015 Sep 12; 6(30). PMID: 26359629 Free PMC article.
Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo. D Sommermeyer, M Hudecek, +4 authors, S R Riddell. less Leukemia, 2015 Sep 16; 30(2). PMID: 26369987 Free PMC article. Highly Cited.
Lymphoma Immunotherapy: Current Status. Roberta Zappasodi, Filippo de Braud, Massimo Di Nicola. Front Immunol, 2015 Sep 22; 6. PMID: 26388871 Free PMC article. Review.
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Chia-Yung Wu, Kole T Roybal, +2 authors, Elias M Puchner, James Onuffer, Wendell A Lim. less Science, 2015 Sep 26; 350(6258). PMID: 26405231 Free PMC article. Highly Cited.
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template. Blythe D Sather, Guillermo S Romano Ibarra, +12 authors, David J Rawlings. less Sci Transl Med, 2015 Oct 02; 7(307). PMID: 26424571 Free PMC article. Highly Cited.
CD19-redirected chimeric antigen receptor-modified T cells: a promising immunotherapy for children and adults with B-cell acute lymphoblastic leukemia (ALL). Sarah K Tasian, Rebecca A Gardner. Ther Adv Hematol, 2015 Oct 02; 6(5). PMID: 26425336 Free PMC article. Review.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells. Zeguo Zhao, Maud Condomines, +5 authors, Michel Sadelain. less Cancer Cell, 2015 Oct 16; 28(4). PMID: 26461090 Free PMC article. Highly Cited.
Novel immunotherapies in lymphoid malignancies. Connie Lee Batlevi, Eri Matsuki, Renier J Brentjens, Anas Younes. Nat Rev Clin Oncol, 2015 Nov 04; 13(1). PMID: 26525683 Free PMC article. Highly Cited. Review.
CAR T-cell immunotherapy: The path from the by-road to the freeway? Lynsey M Whilding, John Maher. Mol Oncol, 2015 Nov 14; 9(10). PMID: 26563646 Free PMC article. Review.
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment. Luo Gu, David J Mooney. Nat Rev Cancer, 2015 Dec 24; 16(1). PMID: 26694936 Free PMC article. Highly Cited. Review.
Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors. Hannah Karlsson, Emma Svensson, +5 authors, Angelica Loskog. less PLoS One, 2015 Dec 25; 10(12). PMID: 26700307 Free PMC article.
Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors. Daniel T Harris, David M Kranz. Trends Pharmacol Sci, 2015 Dec 26; 37(3). PMID: 26705086 Free PMC article. Review.
Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. David T Rodgers, Magdalena Mazagova, +15 authors, Travis S Young. less Proc Natl Acad Sci U S A, 2016 Jan 14; 113(4). PMID: 26759369 Free PMC article. Highly Cited.
Chimeric antigen receptor-redirected T cells return to the bench. Claudia Geldres, Barbara Savoldo, Gianpietro Dotti. Semin Immunol, 2016 Jan 23; 28(1). PMID: 26797495 Free PMC article. Review.
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia. Joseph A Fraietta, Kyle A Beckwith, +24 authors, Marcela V Maus. less Blood, 2016 Jan 28; 127(9). PMID: 26813675 Free PMC article. Highly Cited.
Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy. Hanren Dai, Yao Wang, Xuechun Lu, Weidong Han. J Natl Cancer Inst, 2016 Jan 29; 108(7). PMID: 26819347 Free PMC article. Highly Cited. Review.
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. Kinga Majchrzak, Michelle H Nelson, +5 authors, Chrystal M Paulos. less Cancer Immunol Immunother, 2016 Jan 31; 65(3). PMID: 26825102 Free PMC article. Review.
Immunotherapy in Chronic Lymphocytic Leukaemia (CLL). Ciara L Freeman, John G Gribben. Curr Hematol Malig Rep, 2016 Feb 10; 11(1). PMID: 26857283 Free PMC article. Review.
High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity. R C Lynn, Y Feng, +4 authors, D J Powell. less Leukemia, 2016 Feb 24; 30(6). PMID: 26898190 Free PMC article.
T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Nathan Singh, Irina Kulikovskaya, +7 authors, Stephan A Grupp. less Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942053 Free PMC article.
Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy. Mark O'Hara, Caitlin Stashwick, Andrew R Haas, Janos L Tanyi. Immunotherapy, 2016 Mar 15; 8(4). PMID: 26973126 Free PMC article. Review.
Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects. Yelei Guo, Yao Wang, Weidong Han. J Immunol Res, 2016 Mar 22; 2016. PMID: 26998495 Free PMC article. Review.
Chimeric antigen receptor-modified T cells strike back. Matthew J Frigault, Marcela V Maus. Int Immunol, 2016 Mar 30; 28(7). PMID: 27021308 Free PMC article. Review.
Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy. Marcela V Maus, Carl H June. Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084741 Free PMC article. Highly Cited. Review.
CAR T Cell Therapy in Acute Lymphoblastic Leukemia and Potential for Chronic Lymphocytic Leukemia. Nathan Singh, Noelle V Frey, Stephan A Grupp, Shannon L Maude. Curr Treat Options Oncol, 2016 Apr 22; 17(6). PMID: 27098534 Review.
Novel Therapeutic Strategies in Acute Lymphoblastic Leukemia. Ajoy Dias, Saad J Kenderian, Gustavo F Westin, Mark R Litzow. Curr Hematol Malig Rep, 2016 Apr 22; 11(4). PMID: 27101015 Review.
Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor. Agnes Shuk-Yee Lo, Chen Xu, Akikazu Murakami, Wayne A Marasco. Mol Ther Oncolytics, 2014 Jan 01; 1. PMID: 27119093 Free PMC article.
Strategies to genetically engineer T cells for cancer immunotherapy. Timothy T Spear, Kaoru Nagato, Michael I Nishimura. Cancer Immunol Immunother, 2016 May 04; 65(6). PMID: 27138532 Free PMC article. Review.
Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer. Yu Cao, David T Rodgers, +17 authors, Travis S Young. less Angew Chem Int Ed Engl, 2016 May 05; 55(26). PMID: 27145250 Free PMC article.
How Chimeric Antigen Receptor Design Affects Adoptive T Cell Therapy. Albert T Gacerez, Benjamine Arellano, Charles L Sentman. J Cell Physiol, 2016 May 11; 231(12). PMID: 27163336 Free PMC article. Review.
Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer. Chuan Jin, Grammatiki Fotaki, +3 authors, Di Yu. less EMBO Mol Med, 2016 May 18; 8(7). PMID: 27189167 Free PMC article.
Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors. Hiroki Torikai, Laurence Jn Cooper. Mol Ther, 2016 May 21; 24(7). PMID: 27203439 Free PMC article. Review.
CAR T Cell Therapy: A Game Changer in Cancer Treatment. Hilde Almåsbak, Tanja Aarvak, Mohan C Vemuri. J Immunol Res, 2016 Jun 15; 2016. PMID: 27298832 Free PMC article. Review.
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma. Avery D Posey, Robert D Schwab, +19 authors, Carl H June. less Immunity, 2016 Jun 23; 44(6). PMID: 27332733 Free PMC article. Highly Cited.
A Perspective of Immunotherapy for Prostate Cancer. Ida Silvestri, Susanna Cattarino, +3 authors, Alessandro Sciarra. less Cancers (Basel), 2016 Jul 12; 8(7). PMID: 27399780 Free PMC article. Review.
Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma. M Kazim Panjwani, Jenessa B Smith, +4 authors, Nicola J Mason. less Mol Ther, 2016 Jul 13; 24(9). PMID: 27401141 Free PMC article.
Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy. Jenessa B Smith, Evripidis Lanitis, +5 authors, Daniel J Powell. less Mol Ther, 2016 Jul 22; 24(11). PMID: 27439899 Free PMC article.
Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level. De-Gang Song, Qunrui Ye, +3 authors, Daniel J Powell. less J Hematol Oncol, 2016 Jul 22; 9(1). PMID: 27439908 Free PMC article.
Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Yun Bai, Shifeng Kan, +5 authors, Hongkui Deng. less Cell Discov, 2015 Jan 01; 1. PMID: 27462436 Free PMC article.
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA. Nadia Mensali, Fan Ying, +9 authors, Johanna Olweus. less Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467957 Free PMC article.
Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You. Marco Ruella, Carl H June. Curr Hematol Malig Rep, 2016 Aug 01; 11(5). PMID: 27475429 Review.
Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity. Wenpeng Li, Linjie Guo, +8 authors, Andras Heczey. less Hum Gene Ther, 2016 Aug 18; 28(5). PMID: 27530312 Free PMC article.
Redirecting Specificity of T cells Using the Sleeping Beauty System to Express Chimeric Antigen Receptors by Mix-and-Matching of VL and VH Domains Targeting CD123+ Tumors. Radhika Thokala, Simon Olivares, +9 authors, Laurence J N Cooper. less PLoS One, 2016 Aug 23; 11(8). PMID: 27548616 Free PMC article.
Engineered T cells: the promise and challenges of cancer immunotherapy. Andrew D Fesnak, Carl H June, Bruce L Levine. Nat Rev Cancer, 2016 Aug 24; 16(9). PMID: 27550819 Free PMC article. Highly Cited. Review.
Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+ T Cells for Manufacturing of Gene Therapy Medicinal Products. Christoph Priesner, Krasimira Aleksandrova, +10 authors, Ulrike Koehl. less Hum Gene Ther, 2016 Aug 27; 27(10). PMID: 27562135 Free PMC article.
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Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse. Saad S Kenderian, David L Porter, Saar Gill. Biol Blood Marrow Transplant, 2016 Sep 18; 23(2). PMID: 27638367 Free PMC article. Review.
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination. Anke Redeker, Ramon Arens. Front Immunol, 2016 Sep 23; 7. PMID: 27656185 Free PMC article. Review.
Recent advances and novel treatment paradigms in acute lymphocytic leukemia. Nikolaos Papadantonakis, Anjali S Advani. Ther Adv Hematol, 2016 Oct 04; 7(5). PMID: 27695616 Free PMC article. Review.
Recent advances in T-cell engineering for use in immunotherapy. Preeti Sharma, David M Kranz. F1000Res, 2016 Oct 06; 5. PMID: 27703664 Free PMC article. Review.
Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome. Linan Wang, Ning Ma, +7 authors, Hiroshi Shiku. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757303 Free PMC article.
Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies. Marco Ruella, Marcela V Maus. Comput Struct Biotechnol J, 2016 Oct 21; 14. PMID: 27761200 Free PMC article. Highly Cited. Review.
Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers. Qiong J Wang, Zhiya Yu, +4 authors, James C Yang. less Clin Cancer Res, 2016 Nov 03; 23(9). PMID: 27803044 Free PMC article.
Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research. Kanako Inoo, Ryo Inagaki, +4 authors, Naoki Okada. less Mol Ther Oncolytics, 2016 Dec 03; 3. PMID: 27909701 Free PMC article.
Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia. Noelle V Frey, David L Porter. Hematology Am Soc Hematol Educ Program, 2016 Dec 04; 2016(1). PMID: 27913530 Free PMC article. Review.
Driving gene-engineered T cell immunotherapy of cancer. Laura A Johnson, Carl H June. Cell Res, 2016 Dec 28; 27(1). PMID: 28025979 Free PMC article. Highly Cited. Review.
PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR. Elise A Chong, J Joseph Melenhorst, +5 authors, Stephen J Schuster. less Blood, 2016 Dec 30; 129(8). PMID: 28031179 Free PMC article. Highly Cited.
Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol. Xiao-Yi Tang, Yao Sun, +5 authors, Hu Chen. less BMJ Open, 2017 Jan 01; 6(12). PMID: 28039295 Free PMC article.
T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients. Yarne Klaver, Sabine C L van Steenbergen, +2 authors, Stefan Sleijfer, Reno Debets, Cor H J Lamers. less Front Immunol, 2017 Jan 14; 7. PMID: 28082983 Free PMC article.
Improving T Cell Expansion with a Soft Touch. Lester H Lambert, Geraldine K E Goebrecht, +6 authors, Lance C Kam. less Nano Lett, 2017 Jan 27; 17(2). PMID: 28122453 Free PMC article.
Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells. Malika Hale, Taylor Mesojednik, +6 authors, Thor A Wagner. less Mol Ther, 2017 Feb 02; 25(3). PMID: 28143740 Free PMC article. Highly Cited.
Targeting O-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Julien Fleurence, Sophie Fougeray, +5 authors, Stéphane Birklé. less J Immunol Res, 2017 Feb 06; 2017. PMID: 28154831 Free PMC article. Review.
Applications of Immunogenomics to Cancer. X Shirley Liu, Elaine R Mardis. Cell, 2017 Feb 12; 168(4). PMID: 28187283 Free PMC article. Highly Cited. Review.
CARs in the Lead Against Multiple Myeloma. Maria Ormhøj, Felipe Bedoya, Matthew J Frigault, Marcela V Maus. Curr Hematol Malig Rep, 2017 Feb 25; 12(2). PMID: 28233151 Free PMC article. Review.
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells. Le Qin, Yunxin Lai, +16 authors, Peng Li. less J Hematol Oncol, 2017 Mar 16; 10(1). PMID: 28288656 Free PMC article.
Setting the target for pemphigus vulgaris therapy. Christoph T Ellebrecht, Aimee S Payne. JCI Insight, 2017 Mar 16; 2(5). PMID: 28289723 Free PMC article. Review.
Clinical development of anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma. Shinichi Makita, Kiyoshi Yoshimura, Kensei Tobinai. Cancer Sci, 2017 Mar 17; 108(6). PMID: 28301076 Free PMC article. Review.
Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells. Malika Hale, Baeckseung Lee, +9 authors, David J Rawlings. less Mol Ther Methods Clin Dev, 2017 Mar 28; 4. PMID: 28345004 Free PMC article.
Chimeric antigen receptor engineered stem cells: a novel HIV therapy. Anjie Zhen, Mayra A Carrillo, Scott G Kitchen. Immunotherapy, 2017 Mar 31; 9(5). PMID: 28357916 Free PMC article. Review.
The challenges of solid tumor for designer CAR-T therapies: a 25-year perspective. Richard P Junghans. Cancer Gene Ther, 2017 Apr 11; 24(3). PMID: 28392558
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond. ZeNan L Chang, Yvonne Y Chen. Trends Mol Med, 2017 Apr 19; 23(5). PMID: 28416139 Free PMC article. Review.
CD19 Isoforms Enabling Resistance to CART-19 Immunotherapy Are Expressed in B-ALL Patients at Initial Diagnosis. Jeannette Fischer, Claudia Paret, +12 authors, Jörg Faber. less J Immunother, 2017 Apr 26; 40(5). PMID: 28441264 Free PMC article.
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Kole T Roybal, Wendell A Lim. Annu Rev Immunol, 2017 Apr 28; 35. PMID: 28446063 Free PMC article. Review.
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A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization. Esther Drent, Maria Themeli, +9 authors, Tuna Mutis. less Mol Ther, 2017 May 17; 25(8). PMID: 28506593 Free PMC article. Highly Cited.
Genetic Modification of T Cells. Richard A Morgan, Benjamin Boyerinas. Biomedicines, 2017 May 26; 4(2). PMID: 28536376 Free PMC article. Review.
Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells. Michael Schmueck-Henneresse, Bilal Omer, +9 authors, Cliona M Rooney. less J Immunol, 2017 May 28; 199(1). PMID: 28550199 Free PMC article.
Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity. Congcong Zhang, Pranav Oberoi, +4 authors, Winfried S Wels. less Front Immunol, 2017 Jun 03; 8. PMID: 28572802 Free PMC article. Highly Cited.
Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells. Marco Ruella, Michael Klichinsky, +7 authors, Saar Gill. less Cancer Discov, 2017 Jun 04; 7(10). PMID: 28576927 Free PMC article.
Redirected Primary Human Chimeric Antigen Receptor Natural Killer Cells As an "Off-the-Shelf Immunotherapy" for Improvement in Cancer Treatment. Olaf Oberschmidt, Stephan Kloess, Ulrike Koehl. Front Immunol, 2017 Jun 27; 8. PMID: 28649246 Free PMC article. Review.
In Vivo Murine-Matured Human CD3+ Cells as a Preclinical Model for T Cell-Based Immunotherapies. Kevin G Haworth, Christina Ironside, +3 authors, Hans-Peter Kiem. less Mol Ther Methods Clin Dev, 2017 Jun 27; 6. PMID: 28649577 Free PMC article.
Chimeric Antigen Receptor Therapy in Acute Lymphoblastic Leukemia Clinical Practice. Marlise R Luskin, Daniel J DeAngelo. Curr Hematol Malig Rep, 2017 Jun 29; 12(4). PMID: 28656487 Review.
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells. Xueyang Guo, Hang Zheng, +3 authors, Kaitai Yao. less Sci Rep, 2017 Jul 09; 7(1). PMID: 28687750 Free PMC article.
Combination of celecoxib (Celebrex®) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas. Tam Nm Dinh, Alexandra S Onea, Ali R Jazirehi. Am J Clin Exp Immunol, 2017 Aug 15; 6(3). PMID: 28804691 Free PMC article. Review.
CD28 and 41BB Costimulation Enhances the Effector Function of CD19-Specific Engager T Cells. Mireya Paulina Velasquez, Arpad Szoor, +5 authors, Stephen Gottschalk. less Cancer Immunol Res, 2017 Aug 20; 5(10). PMID: 28821531 Free PMC article.
Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells. Y Lai, J Weng, +14 authors, P Li. less Leukemia, 2017 Aug 26; 32(3). PMID: 28841215
Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia. Mingxue Fan, Minghao Li, +5 authors, Lei Yu. less J Hematol Oncol, 2017 Aug 31; 10(1). PMID: 28851445 Free PMC article. Highly Cited. Review.
Chimeric antigen receptor T-cell therapies for lymphoma. Jennifer N Brudno, James N Kochenderfer. Nat Rev Clin Oncol, 2017 Sep 01; 15(1). PMID: 28857075 Highly Cited. Review.
Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs. Chao Wang, Wujin Sun, +2 authors, Yanqi Ye, Hunter N Bomba, Zhen Gu. less Theranostics, 2017 Sep 16; 7(14). PMID: 28912891 Free PMC article. Review.
Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Karen Thudium Mueller, Shannon L Maude, +11 authors, Simon F Lacey. less Blood, 2017 Sep 25; 130(21). PMID: 28935694 Free PMC article. Highly Cited.
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18. Biliang Hu, Jiangtao Ren, +5 authors, Carl H June. less Cell Rep, 2017 Sep 28; 20(13). PMID: 28954221 Free PMC article. Highly Cited.
Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent. Diogo Gomes-Silva, Malini Mukherjee, +8 authors, Maksim Mamonkin. less Cell Rep, 2017 Oct 06; 21(1). PMID: 28978471 Free PMC article. Highly Cited.
Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor. Rachel S Leibman, Max W Richardson, +14 authors, James L Riley. less PLoS Pathog, 2017 Oct 13; 13(10). PMID: 29023549 Free PMC article.
CAR T Therapy Targeting ICAM-1 Eliminates Advanced Human Thyroid Tumors. Irene M Min, Enda Shevlin, +13 authors, Moonsoo M Jin. less Clin Cancer Res, 2017 Oct 14; 23(24). PMID: 29025766 Free PMC article.
Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children. Michael Merker, Verena Pfirrmann, +5 authors, Eva Rettinger. less Oncotarget, 2017 Oct 17; 8(39). PMID: 29029499 Free PMC article.
Clinical trials of CAR-T cells in China. Bingshan Liu, Yongping Song, Delong Liu. J Hematol Oncol, 2017 Oct 24; 10(1). PMID: 29058636 Free PMC article. Highly Cited.
Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia. Eduardo Laborda, Magdalena Mazagova, +8 authors, Travis S Young. less Int J Mol Sci, 2017 Oct 28; 18(11). PMID: 29077054 Free PMC article.
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response. Qiong Xue, Emily Bettini, +11 authors, Jing Zhou. less J Immunother Cancer, 2017 Nov 22; 5(1). PMID: 29157295 Free PMC article.
Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions. Sang Yun Lee, Philip Olsen, +9 authors, Brian G Till. less J Immunother, 2017 Nov 28; 41(1). PMID: 29176334 Free PMC article.
TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Tiara T Byrd, Kristen Fousek, +22 authors, Nabil Ahmed. less Cancer Res, 2017 Dec 01; 78(2). PMID: 29183891 Free PMC article.
Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients. Katherine T Marcucci, Julie K Jadlowsky, +10 authors, Carl H June. less Mol Ther, 2017 Dec 06; 26(1). PMID: 29203150 Free PMC article.
Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy. Christopher A Klebanoff, Joseph G Crompton, +16 authors, Nicholas P Restifo. less JCI Insight, 2017 Dec 08; 2(23). PMID: 29212954 Free PMC article.
Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. Stephen J Schuster, Jakub Svoboda, +13 authors, Carl H June. less N Engl J Med, 2017 Dec 12; 377(26). PMID: 29226764 Free PMC article. Highly Cited.
Emerging trends in the immunotherapy of pancreatic cancer. Kasturi Banerjee, Sushil Kumar, +10 authors, Maneesh Jain. less Cancer Lett, 2017 Dec 16; 417. PMID: 29242097 Free PMC article. Review.
Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer. Saul J Priceman, Ethan A Gerdts, +15 authors, Stephen J Forman. less Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308300 Free PMC article.
Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy. Shivani Srivastava, Stanley R Riddell. J Immunol, 2018 Jan 10; 200(2). PMID: 29311388 Free PMC article. Highly Cited. Review.
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. Sonia Guedan, Avery D Posey, +14 authors, Carl H June. less JCI Insight, 2018 Jan 13; 3(1). PMID: 29321369 Free PMC article. Highly Cited.
Targeting T-cell malignancies using anti-CD4 CAR NK-92 cells. Kevin G Pinz, Elizabeth Yakaboski, +11 authors, Yupo Ma. less Oncotarget, 2018 Jan 20; 8(68). PMID: 29348865 Free PMC article.
Optimized DNA electroporation for primary human T cell engineering. Zhang Zhang, Shunfang Qiu, Xiaopeng Zhang, Wei Chen. BMC Biotechnol, 2018 Jan 31; 18(1). PMID: 29378552 Free PMC article.
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. Shannon L Maude, Theodore W Laetsch, +32 authors, Stephan A Grupp. less N Engl J Med, 2018 Feb 01; 378(5). PMID: 29385370 Free PMC article. Highly Cited.
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression. Chungyong Han, Su-Jung Sim, +11 authors, Byoung S Kwon. less Nat Commun, 2018 Feb 03; 9(1). PMID: 29391449 Free PMC article.
A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects. Yuki Kagoya, Shinya Tanaka, +6 authors, Naoto Hirano. less Nat Med, 2018 Feb 06; 24(3). PMID: 29400710 Free PMC article. Highly Cited.
CAR-T cells: the long and winding road to solid tumors. Maria Michela D'Aloia, Ilaria Grazia Zizzari, +2 authors, Benedetto Sacchetti, Luca Pierelli, Maurizio Alimandi. less Cell Death Dis, 2018 Feb 17; 9(3). PMID: 29449531 Free PMC article. Highly Cited. Review.
CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures. Anna Nowak, Dominik Lock, +9 authors, Alexander Scheffold. less Front Immunol, 2018 Feb 23; 9. PMID: 29467769 Free PMC article.
T-cell Immunotherapies and the Role of Nonclinical Assessment: The Balance between Efficacy and Pathology. Michaela E Sharpe. Toxicol Pathol, 2018 Feb 24; 46(2). PMID: 29471776 Free PMC article. Review.
In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia. Zhi Cheng, Runhong Wei, +15 authors, Pin Wang. less Mol Ther, 2018 Mar 06; 26(4). PMID: 29503204 Free PMC article.
T-bet promotes potent antitumor activity of CD4+ CAR T cells. Albert T Gacerez, Charles L Sentman. Cancer Gene Ther, 2018 Mar 09; 25(5-6). PMID: 29515240 Free PMC article.
The Pharmacology of T Cell Therapies. Michael C Milone, Vijay G Bhoj. Mol Ther Methods Clin Dev, 2018 Mar 20; 8. PMID: 29552577 Free PMC article. Review.
Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma. Zhongzhen Yi, Brooke L Prinzing, +2 authors, Felicia Cao, Stephen Gottschalk, Giedre Krenciute. less Mol Ther Methods Clin Dev, 2018 Mar 20; 9. PMID: 29552579 Free PMC article.
The development of CAR design for tumor CAR-T cell therapy. Dandan Xu, Guoliang Jin, +5 authors, Junnian Zheng. less Oncotarget, 2018 Mar 24; 9(17). PMID: 29568411 Free PMC article. Review.
Effective Targeting of Multiple B-Cell Maturation Antigen-Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells. Kevin M Friedman, Tracy E Garrett, +5 authors, Richard A Morgan. less Hum Gene Ther, 2018 Apr 12; 29(5). PMID: 29641319 Free PMC article. Highly Cited.
Clinical use of lentiviral vectors. Michael C Milone, Una O'Doherty. Leukemia, 2018 Apr 15; 32(7). PMID: 29654266 Free PMC article. Highly Cited. Review.
False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy. Theodore W Laetsch, Shannon L Maude, +7 authors, Stephan A Grupp. less Blood, 2018 Apr 20; 131(23). PMID: 29669777 Free PMC article.
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Roddy S O'Connor, Lili Guo, +10 authors, Michael C Milone. less Sci Rep, 2018 Apr 21; 8(1). PMID: 29674640 Free PMC article.
An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity. Marcela V Maus, Jason Plotkin, +6 authors, Michel Sadelain. less Mol Ther Oncolytics, 2017 Jan 11; 3. PMID: 29675462 Free PMC article.
Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium. Andrew R Medvec, Christopher Ecker, +4 authors, James L Riley. less Mol Ther Methods Clin Dev, 2018 Apr 25; 8. PMID: 29687031 Free PMC article.
Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells. Anandani Nellan, Christopher Rota, +6 authors, Daniel W Lee. less J Immunother Cancer, 2018 May 02; 6(1). PMID: 29712574 Free PMC article.
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Joseph A Fraietta, Simon F Lacey, +34 authors, J Joseph Melenhorst. less Nat Med, 2018 May 02; 24(5). PMID: 29713085 Free PMC article. Highly Cited.
Advances on chimeric antigen receptor-modified T-cell therapy for oncotherapy. Yanyu Pang, Xiaoyang Hou, +2 authors, Chunsheng Yang, Yanqun Liu, Guan Jiang. less Mol Cancer, 2018 May 18; 17(1). PMID: 29769134 Free PMC article. Review.
Are ovarian cancer stem cells the target for innovative immunotherapy? Liang Wang, Tianmin Xu, Manhua Cui. Onco Targets Ther, 2018 May 22; 11. PMID: 29780254 Free PMC article. Review.
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication. Christopher C Kloss, Jihyun Lee, +7 authors, Carl H June. less Mol Ther, 2018 May 29; 26(7). PMID: 29807781 Free PMC article. Highly Cited.
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. Miriam Y Kim, Kyung-Rok Yu, +22 authors, Saar Gill. less Cell, 2018 Jun 02; 173(6). PMID: 29856956 Free PMC article. Highly Cited.
PiggyBac-Engineered T Cells Expressing CD19-Specific CARs that Lack IgG1 Fc Spacers Have Potent Activity against B-ALL Xenografts. David C Bishop, Ning Xu, +4 authors, Kenneth P Micklethwaite. less Mol Ther, 2018 Jun 05; 26(8). PMID: 29861327 Free PMC article.
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma. Concetta Quintarelli, Domenico Orlando, +14 authors, Ignazio Caruana. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872565 Free PMC article.
Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma. De-Xiu Bu, Reshma Singh, +19 authors, Michael C Milone. less Oncotarget, 2018 Jun 15; 9(40). PMID: 29899820 Free PMC article.
Overcoming Resistance of Human Non-Hodgkin's Lymphoma to CD19-CAR CTL Therapy by Celecoxib and Histone Deacetylase Inhibitors. Antoni Xavier Torres-Collado, Ali R Jazirehi. Cancers (Basel), 2018 Jun 16; 10(6). PMID: 29904021 Free PMC article.
Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation. Scott S Graves, Maura H Parker, Rainer Storb. ILAR J, 2018 Jul 17; 59(3). PMID: 30010833 Free PMC article.
The application of CAR-T cell therapy in hematological malignancies: advantages and challenges. Zijun Zhao, Yu Chen, +2 authors, Minhao Wu. less Acta Pharm Sin B, 2018 Aug 16; 8(4). PMID: 30109179 Free PMC article. Review.
CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease. Katherine C Pehlivan, Brynn B Duncan, Daniel W Lee. Curr Hematol Malig Rep, 2018 Aug 19; 13(5). PMID: 30120708 Review.
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies. Hannah M Knochelmann, Aubrey S Smith, +3 authors, Chrystal M Paulos. less Front Immunol, 2018 Aug 25; 9. PMID: 30140266 Free PMC article. Highly Cited. Review.
Strategies to Address Chimeric Antigen Receptor Tonic Signaling. Adam Ajina, John Maher. Mol Cancer Ther, 2018 Sep 06; 17(9). PMID: 30181329 Free PMC article. Review.
Combining immunotherapy with radiation therapy in thoracic oncology. Shahed N Badiyan, Michael C Roach, +7 authors, Charles B Simone. less J Thorac Dis, 2018 Sep 13; 10(Suppl 21). PMID: 30206494 Free PMC article. Review.
Effect of transplant status in CD19-targeted CAR T-cell therapy: a systematic review and meta-analysis. Kathleen Nagle, Barbara Tafuto, Lisa Palladino Kim, J Scott Parrott. Med Oncol, 2018 Sep 13; 35(11). PMID: 30206753 Systematic Review.
4-1BB enhancement of CAR T function requires NF-κB and TRAFs. Gongbo Li, Justin C Boucher, +8 authors, Marco L Davila. less JCI Insight, 2018 Sep 21; 3(18). PMID: 30232281 Free PMC article.
The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL. Matthew H Forsberg, Amritava Das, Krishanu Saha, Christian M Capitini. Ther Clin Risk Manag, 2018 Sep 21; 14. PMID: 30233192 Free PMC article. Review.
Chimeric Antigen Receptor T-Cells: Successful Translation of the First Cell and Gene Therapy From Bench to Bedside. Luis G Rodriguez-Cartagena, Bradley S Bowles, +3 authors, Alexandra J Greenberg-Worisek. less Clin Transl Sci, 2018 Sep 23; 11(6). PMID: 30242965 Free PMC article.
Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma. Jun Zhang, L Jeffrey Medeiros, Ken H Young. Front Oncol, 2018 Sep 27; 8. PMID: 30250823 Free PMC article. Review.
The efficacy and safety of anti-CD19/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis. Hui Zhou, Yuling Luo, +5 authors, Xuelei Ma. less BMC Cancer, 2018 Sep 28; 18(1). PMID: 30257649 Free PMC article.
Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory. Sophie Viaud, Jennifer S Y Ma, +10 authors, Travis S Young. less Proc Natl Acad Sci U S A, 2018 Oct 31; 115(46). PMID: 30373813 Free PMC article.
CART Immunotherapy: Development, Success, and Translation to Malignant Gliomas and Other Solid Tumors. Anna C Filley, Mario Henriquez, Mahua Dey. Front Oncol, 2018 Nov 06; 8. PMID: 30386740 Free PMC article. Review.
Chimeric-Antigen-Receptor (CAR) T Cells and the Factors Influencing their Therapeutic Efficacy. Victoria G Kravets, Yi Zhang, Hongxing Sun. J Immunol Res Ther, 2017 Jun 01; 2(1). PMID: 30443604 Free PMC article.
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release. Yiyang Xu, Zhiyuan Yang, +11 authors, Cheng Liu. less Cell Discov, 2018 Nov 28; 4. PMID: 30479831 Free PMC article.
Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells. John P Murad, Anna K Kozlowska, +8 authors, Saul J Priceman. less Front Immunol, 2018 Dec 05; 9. PMID: 30510550 Free PMC article.
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia. Stephanie Vairy, Julia Lopes Garcia, Pierre Teira, Henrique Bittencourt. Drug Des Devel Ther, 2018 Dec 07; 12. PMID: 30518999 Free PMC article. Review.
Immunotherapy for pediatric brain tumors: past and present. Jessica B Foster, Peter J Madsen, +6 authors, Angela J Waanders. less Neuro Oncol, 2019 Sep 11; 21(10). PMID: 31504801 Free PMC article. Review.
Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells. William R Strohl, Michael Naso. Antibodies (Basel), 2019 Sep 24; 8(3). PMID: 31544847 Free PMC article. Review.
CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV. Gloria B Kim, Kristen Hege, James L Riley. Front Immunol, 2019 Oct 16; 10. PMID: 31611880 Free PMC article. Review.
Current Advances in Immunotherapy for Acute Leukemia: An Overview of Antibody, Chimeric Antigen Receptor, Immune Checkpoint, and Natural Killer. Yufeng Shang, Fuling Zhou. Front Oncol, 2019 Oct 17; 9. PMID: 31616632 Free PMC article. Review.
CD137L-DCs, Potent Immune-Stimulators-History, Characteristics, and Perspectives. Qun Zeng, Yubin Zhou, Herbert Schwarz. Front Immunol, 2019 Oct 22; 10. PMID: 31632390 Free PMC article. Review.
Genetically engineered T cells for cancer immunotherapy. Dan Li, Xue Li, +8 authors, Wei Wang. less Signal Transduct Target Ther, 2019 Oct 23; 4. PMID: 31637014 Free PMC article. Review.
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The Application of Nanobody in CAR-T Therapy. Chaolemeng Bao, Quanli Gao, +7 authors, Xian-Hui Wu. less Biomolecules, 2021 Feb 12; 11(2). PMID: 33567640 Free PMC article. Review.
Testing the Specificity of Compounds Designed to Inhibit CPT1A in T Cells. Roddy S O'Connor, Michael C Milone. Methods Mol Biol, 2019 Nov 30; 2097. PMID: 31776920 Free PMC article.
T cells selectively filter oscillatory signals on the minutes timescale. Geoff P O'Donoghue, Lukasz J Bugaj, +3 authors, Wendell A Lim. less Proc Natl Acad Sci U S A, 2021 Feb 26; 118(9). PMID: 33627405 Free PMC article.
Perspectives for the Use of CAR-T Cells for the Treatment of Multiple Myeloma. Marcin Jasiński, Grzegorz W Basak, Wiesław W Jedrzejczak. Front Immunol, 2021 Mar 16; 12. PMID: 33717171 Free PMC article. Review.
Bispecific c-Met/PD-L1 CAR-T Cells Have Enhanced Therapeutic Effects on Hepatocellular Carcinoma. Wei Jiang, Tao Li, +9 authors, Guozhong Ji. less Front Oncol, 2021 Mar 30; 11. PMID: 33777728 Free PMC article.
Designed improvement to T-cell immunotherapy by multidimensional single cell profiling. Irfan N Bandey, Jay R T Adolacion, +10 authors, Navin Varadarajan. less J Immunother Cancer, 2021 Mar 17; 9(3). PMID: 33722906 Free PMC article.
APDL1-CART cells exhibit strong PD-L1-specific activity against leukemia cells. Qunyi Peng, Xiongpeng Zhu, +3 authors, Shengquan Liu. less Aging (Albany NY), 2021 Mar 04; 13(5). PMID: 33653969 Free PMC article.
CAR-T cell therapy: current limitations and potential strategies. Robert C Sterner, Rosalie M Sterner. Blood Cancer J, 2021 Apr 08; 11(4). PMID: 33824268 Free PMC article. Review.
CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus. Ana Textor, Laura Grunewald, +12 authors, Annette Künkele. less Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33801448 Free PMC article.
Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals. Kento Fujiwara, Masaki Kitaura, +3 authors, Naoki Okada. less Int J Mol Sci, 2021 Apr 04; 22(5). PMID: 33804441 Free PMC article.
Perspectives on outpatient administration of CAR-T cell therapy in aggressive B-cell lymphoma and acute lymphoblastic leukemia. G Doug Myers, Michael R Verneris, Andre Goy, Richard T Maziarz. J Immunother Cancer, 2021 Apr 14; 9(4). PMID: 33846220 Free PMC article. Review.
CAR T-cell therapy in multiple myeloma: more room for improvement. Phaik Ju Teoh, Wee Joo Chng. Blood Cancer J, 2021 May 01; 11(4). PMID: 33927192 Free PMC article. Review.
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy. Ying Gong, Roel G J Klein Wolterink, +2 authors, Jianxiang Wang, Gerard M J Bos, Wilfred T V Germeraad. less J Hematol Oncol, 2021 May 03; 14(1). PMID: 33933160 Free PMC article. Review.
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nathan Singh, Noelle V Frey, +33 authors, Marco Ruella. less Nat Med, 2021 Apr 24; 27(5). PMID: 33888899 Free PMC article.
CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity. A Stoll, H Bruns, +6 authors, D Mougiakakos. less Leukemia, 2021 May 23; 35(12). PMID: 34021248 Free PMC article.
How Can We Engineer CAR T Cells to Overcome Resistance? Maya Glover, Stephanie Avraamides, John Maher. Biologics, 2021 May 28; 15. PMID: 34040345 Free PMC article. Review.
The role of small molecules in cell and gene therapy. Lewis L Brayshaw, Carlos Martinez-Fleites, +3 authors, Christopher Herring. less RSC Med Chem, 2021 May 29; 12(3). PMID: 34046619 Free PMC article. Review.
Chimeric Antigen Receptor-Modified T Cells and T Cell-Engaging Bispecific Antibodies: Different Tools for the Same Job. Melanie Schwerdtfeger, Mohamed-Reda Benmebarek, +3 authors, Sebastian Kobold. less Curr Hematol Malig Rep, 2021 May 04; 16(2). PMID: 33939108 Free PMC article. Review.
Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Colby R Maldini, Daniel T Claiborne, +15 authors, Todd M Allen. less Nat Med, 2020 Sep 02; 26(11). PMID: 32868878
CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drug Development. Kenji Hashimoto. Cancers (Basel), 2021 Jun 03; 13(10). PMID: 34064598 Free PMC article. Review.
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells. Zhiliang Bai, Stefan Lundh, +9 authors, Rong Fan. less J Immunother Cancer, 2021 May 20; 9(5). PMID: 34006631 Free PMC article.
Immune-Based Approaches for the Treatment of Pediatric Malignancies. Kristopher R Bosse, Robbie G Majzner, Crystal L Mackall, John M Maris. Annu Rev Cancer Biol, 2020 Mar 01; 4. PMID: 34113750 Free PMC article.
Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. Veronika Mancikova, Michal Smida. Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34073911 Free PMC article. Review.
Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy. Robert D Leone, Jonathan D Powell. Cancer Immunol Res, 2021 Mar 03; 9(3). PMID: 33648947 Free PMC article. Review.
An Update on the HIV DNA Vaccine Strategy. Joseph Hokello, Adhikarimayum Lakhikumar Sharma, Mudit Tyagi. Vaccines (Basel), 2021 Jul 03; 9(6). PMID: 34198789 Free PMC article. Review.
A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains. Kathryn M Cappell, James N Kochenderfer. Nat Rev Clin Oncol, 2021 Jul 08; 18(11). PMID: 34230645 Review.
Making Potent CAR T Cells Using Genetic Engineering and Synergistic Agents. Chi Hoon Park. Cancers (Basel), 2021 Jul 03; 13(13). PMID: 34209505 Free PMC article. Review.
Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Saba Ghassemi, Selene Nunez-Cruz, +15 authors, Michael C Milone. less Cancer Immunol Res, 2018 Jul 22; 6(9). PMID: 30030295 Free PMC article. Highly Cited.
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Cecile Geuijen, Paul Tacken, +38 authors, Mark Throsby. less Nat Commun, 2021 Jul 23; 12(1). PMID: 34290245 Free PMC article.
Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. John C Flickinger, Jeffrey A Rappaport, +4 authors, Scott A Waldman. less Biomark Med, 2021 Jan 21; 15(3). PMID: 33470843 Free PMC article.
Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML. Jan-Erik Meyer, Simon Loff, +6 authors, Armin Ehninger. less Oncoimmunology, 2021 Jul 23; 10(1). PMID: 34290907 Free PMC article.
Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia. Noelle V Frey, Pamela A Shaw, +15 authors, David L Porter. less J Clin Oncol, 2019 Dec 10; 38(5). PMID: 31815579 Free PMC article.
Design and Assessment of Novel Anti-CD30 Chimeric Antigen Receptors with Human Antigen-Recognition Domains. Stephanie Choi, Melissa A Pegues, +3 authors, James N Kochenderfer. less Hum Gene Ther, 2020 Dec 09; 32(13-14). PMID: 33287637 Free PMC article.
Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients. Luca Biasco, Natalia Izotova, +10 authors, Persis J Amrolia. less Nat Cancer, 2021 Aug 05; 2(6). PMID: 34345830 Free PMC article.
Determinants of response and mechanisms of resistance of CAR T-cell therapy in multiple myeloma. Niels W C J van de Donk, Maria Themeli, Saad Z Usmani. Blood Cancer Discov, 2021 Aug 14; 2(4). PMID: 34386775 Free PMC article.
Single-cell imaging of T cell immunotherapy responses in vivo. Chuan Yan, Qiqi Yang, +18 authors, David M Langenau. less J Exp Med, 2021 Aug 21; 218(10). PMID: 34415995 Free PMC article.
PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer and Other Malignancies. Yamin Jie, Guijun Liu, +8 authors, Anxin Gu. less Front Immunol, 2021 Sep 04; 12. PMID: 34475869 Free PMC article.
Engineering enhanced CAR T-cells for improved cancer therapy. Michael C Milone, Jie Xu, +4 authors, J Joseph Melenhorst. less Nat Cancer, 2021 Sep 07; 2(8). PMID: 34485921 Free PMC article. Review.
CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. Miriam Y Kim, Matthew L Cooper, +4 authors, John F DiPersio. less JCI Insight, 2021 Aug 24; 6(16). PMID: 34423790 Free PMC article.
Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope. Alejandrina Hernández-López, Mario A Téllez-González, Paul Mondragón-Terán, Angélica Meneses-Acosta. Front Pharmacol, 2021 Sep 08; 12. PMID: 34489708 Free PMC article. Review.
CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies. Shifaa M Abdin, Daniela Paasch, Michael Morgan, Nico Lachmann. J Immunother Cancer, 2021 Sep 01; 9(8). PMID: 34462325 Free PMC article.
Chimeric antigen receptor (CAR) immunotherapy: basic principles, current advances, and future prospects in neuro-oncology. Hyeon Joo Yoo, Biyan Nathanael Harapan. Immunol Res, 2021 Sep 24; 69(6). PMID: 34554405 Free PMC article. Review.
High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms. Radhika Thokala, Zev A Binder, +7 authors, Donald M O'Rourke. less Front Oncol, 2021 Sep 28; 11. PMID: 34568006 Free PMC article.
State of the CAR-T: Risk of Infections with Chimeric Antigen Receptor T-Cell Therapy and Determinants of SARS-CoV-2 Vaccine Responses. Juliet Meir, Muhammad Abbas Abid, Muhammad Bilal Abid. Transplant Cell Ther, 2021 Sep 30; 27(12). PMID: 34587552 Free PMC article. Review.
Chimeric Antigen Receptor (CAR) T Cell Therapy for B-Acute Lymphoblastic Leukemia (B-ALL). Geoffrey Shouse, Elizabeth Budde, Stephen Forman. Cancer Treat Res, 2021 Oct 10; 181. PMID: 34626362
Improving CAR T-Cell Persistence. Violena Pietrobon, Lauren Anne Todd, +3 authors, Francesco Marincola. less Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34639168 Free PMC article. Review.
Programmable DNA-augmented hydrogels for controlled activation of human lymphocytes. Alexander S Zhovmer, Morgan Chandler, +2 authors, Alexis Manning, Kirill A Afonin, Erdem D Tabdanov. less Nanomedicine, 2021 Jul 21; 37. PMID: 34284132 Free PMC article.
PSMA-Specific CAR-Engineered T Cells for Prostate Cancer: CD28 Outperforms Combined CD28-4-1BB "Super-Stimulation". Gaia Zuccolotto, Alessandro Penna, +4 authors, Antonio Rosato. less Front Oncol, 2021 Oct 19; 11. PMID: 34660275 Free PMC article.
Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells. Kenneth P Micklethwaite, Kavitha Gowrishankar, +17 authors, Emily Blyth. less Blood, 2021 May 12; 138(16). PMID: 33974080 Free PMC article.
Recent advances in lentiviral vectors for gene therapy. Xiaoyu Wang, Cuicui Ma, +4 authors, Yuquan Wei. less Sci China Life Sci, 2021 Oct 29; 64(11). PMID: 34708326 Review.
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction. Baptiste Lamarthée, Armance Marchal, +20 authors, Julien Zuber. less Nat Commun, 2021 Nov 10; 12(1). PMID: 34750385 Free PMC article.
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Axel Hyrenius-Wittsten, Yang Su, +6 authors, Kole T Roybal. less Sci Transl Med, 2021 Apr 30; 13(591). PMID: 33910981 Free PMC article.
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications. Siyuan Qian, Pedro Villarejo-Campos, Damián García-Olmo. J Clin Med, 2021 Nov 14; 10(21). PMID: 34768570 Free PMC article. Review.
Radiotherapy to Enhance Chimeric Antigen Receptor T-Cell Therapeutic Efficacy in Solid Tumors: A Narrative Review. Franziska Hauth, Alice Y Ho, Soldano Ferrone, Dan G Duda. JAMA Oncol, 2021 Apr 23; 7(7). PMID: 33885725 Free PMC article. Review.
T Cell Fitness and Autologous CAR T Cell Therapy in Haematologic Malignancy. Palak H Mehta, Salvatore Fiorenza, +3 authors, Kylie M Quinn. less Front Immunol, 2021 Dec 14; 12. PMID: 34899742 Free PMC article. Review.
Genetically engineered CAR T-immune cells for cancer therapy: recent clinical developments, challenges, and future directions. Sherien M El-Daly, Jihan Hussein. J Appl Biomed, 2019 Mar 01; 17(1). PMID: 34907752 Review.
Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells. Melita Irving, Evripidis Lanitis, +2 authors, Denis Migliorini, Zoltán Ivics, Sonia Guedan. less Hum Gene Ther, 2021 Oct 19; 32(19-20). PMID: 34662233 Free PMC article. Review.
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study. Mohsen Sheykhhasan, Hamed Manoochehri, Paola Dama. Cancer Gene Ther, 2022 Jan 07;. PMID: 34987176 Review.
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors. Tamara Muliaditan, Leena Halim, +19 authors, John Maher. less Cell Rep Med, 2022 Jan 15; 2(12). PMID: 35028604 Free PMC article.
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation. Dasmanthie De Silva, Lucas Ferguson, +8 authors, Jamie Hd Cate. less Elife, 2022 Jan 01; 10. PMID: 34970966 Free PMC article.
Immunology 101: fundamental immunology for the practicing hematologist. Shannon A Carty. Hematology Am Soc Hematol Educ Program, 2021 Dec 11; 2021(1). PMID: 34889423 Free PMC article. Review.
Additional possibilities of chimeric antigen receptor T-cells in B-cell lymphoma: combination therapy. Yan Yang, Jing Zhou, +5 authors, Qingyuan Zhang. less Transl Cancer Res, 2020 Nov 01; 9(11). PMID: 35117332 Free PMC article. Review.
A narrative review of critical factors for better efficacy of CD19 chimeric antigen receptor T cell therapy in the treatment of B cell malignancies. Jia Liu, Luyao Wang, +4 authors, Leina Ma. less Transl Cancer Res, 2020 Sep 01; 9(9). PMID: 35117929 Free PMC article. Review.
Development of a Novel Anti-CD19 CAR Containing a Fully Human scFv and Three Costimulatory Domains. Yupanun Wutti-In, Jatuporn Sujjitjoon, +10 authors, Pa-Thai Yenchitsomanus. less Front Oncol, 2022 Feb 05; 11. PMID: 35117999 Free PMC article.
Splitting signals drives CARs further. Tiffany R King-Peoples, Avery D Posey. Nat Cancer, 2022 Feb 06; 2(9). PMID: 35121869
SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR-T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells. Alijah A Griffith, Kenneth P Callahan, +3 authors, Arthur R Salomon. less J Proteome Res, 2022 Jan 12; 21(2). PMID: 35014847 Free PMC article.
B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages. Shirin Teymouri Nobari, Jafar Nouri Nojadeh, Mehdi Talebi. J Transl Med, 2022 Feb 12; 20(1). PMID: 35144648 Free PMC article. Review.
Chimeric Antigen Receptor T-Cell Therapy in Paediatric B-Cell Precursor Acute Lymphoblastic Leukaemia: Curative Treatment Option or Bridge to Transplant? Jochen Buechner, Ignazio Caruana, +6 authors, Friso G Calkoen. less Front Pediatr, 2022 Feb 12; 9. PMID: 35145941 Free PMC article. Review.
T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice. Olmo Sonzogni, Daniel E Zak, +6 authors, James B Rottman. less Oncoimmunology, 2022 Feb 15; 11(1). PMID: 35154906 Free PMC article.
The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies. Lorena Arranz. Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158848 Free PMC article. Review.
Adoptive Cellular Therapy for Multiple Myeloma Using CAR- and TCR-Transgenic T Cells: Response and Resistance. Franziska Füchsl, Angela M Krackhardt. Cells, 2022 Feb 16; 11(3). PMID: 35159220 Free PMC article. Review.
Rapid manufacturing of non-activated potent CAR T cells. Saba Ghassemi, Joseph S Durgin, +13 authors, Michael C Milone. less Nat Biomed Eng, 2022 Feb 23; 6(2). PMID: 35190680 Free PMC article.
Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma. Sakiko Harada, Miki Ando, +15 authors, Norio Komatsu. less Mol Ther, 2021 Oct 11; 30(2). PMID: 34628050 Free PMC article.
The Role of Bispecific Antibodies in Non-Hodgkin's Lymphoma: From Structure to Prospective Clinical Use. Rita Tavarozzi, Enrica Manzato. Antibodies (Basel), 2022 Mar 01; 11(1). PMID: 35225874 Free PMC article. Review.
Genetic Modification of T Cells for the Immunotherapy of Cancer. Suzanne Quinn, Natasha Lenart, +3 authors, Michael I Nishimura. less Vaccines (Basel), 2022 Mar 27; 10(3). PMID: 35335089 Free PMC article. Review.
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers. Chuan Jin, Jing Ma, +2 authors, Mohanraj Ramachandran, Di Yu, Magnus Essand. less Nat Biomed Eng, 2022 Apr 06;. PMID: 35379957
CAR-T cell therapy for lung cancer: Potential and perspective. Long Chen, Fukun Chen, +5 authors, Yunchao Huang. less Thorac Cancer, 2022 Mar 16; 13(7). PMID: 35289077 Free PMC article. Review.
Comparison of single copy gene‑based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19‑directed CAR T cells in treated patients. Maria-Luisa Schubert, Carolina Berger, +14 authors, Boris Fehse. less Int J Oncol, 2022 Mar 17; 60(5). PMID: 35294040 Free PMC article.
Update for Advance CAR-T Therapy in Solid Tumors, Clinical Application in Peritoneal Carcinomatosis From Colorectal Cancer and Future Prospects. Siyuan Qian, Pedro Villarejo-Campos, +6 authors, Cheng Qian. less Front Immunol, 2022 Apr 12; 13. PMID: 35401510 Free PMC article. Review.
Minimally Invasive Preclinical Monitoring of the Peritoneal Cavity Tumor Microenvironment. Zachary Spencer Dunn, Yan-Ruide Li, +10 authors, Lili Yang. less Cancers (Basel), 2022 Apr 13; 14(7). PMID: 35406547 Free PMC article.
CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+CS1 expressing CAR-T cells. Julie O'Neal, Julie K Ritchey, +14 authors, John F DiPersio. less Leukemia, 2022 Apr 16; 36(6). PMID: 35422095
RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity. Bogang Wu, Xiaowen Zhang, +10 authors, Rong Li. less Nat Commun, 2022 Apr 22; 13(1). PMID: 35444206 Free PMC article.
Development of CAR T Cell Therapy in Children-A Comprehensive Overview. Michael Boettcher, Alexander Joechner, +2 authors, Ziduo Li, Sile Fiona Yang, Patrick Schlegel. less J Clin Med, 2022 Apr 24; 11(8). PMID: 35456250 Free PMC article. Review.
Nanobody-based CAR-T cells for cancer immunotherapy. Pouya Safarzadeh Kozani, Abdolhossein Naseri, +4 authors, Pooria Safarzadeh Kozani. less Biomark Res, 2022 Apr 27; 10(1). PMID: 35468841 Free PMC article. Review.
Effectiveness and Safety of Anti-CD19 Chimeric Antigen Receptor-T Cell Immunotherapy in Patients With Relapsed/Refractory Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis. Zhitao Ying, Yuqin Song, Jun Zhu. Front Pharmacol, 2022 May 14; 13. PMID: 35548364 Free PMC article. Systematic Review.
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Qian Zhang, Morgan E Hresko, +8 authors, Michael C Milone. less Sci Transl Med, 2021 Dec 23; 13(625). PMID: 34936380 Free PMC article.

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