Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor

Makoto Miyara ¹, Yumiko Yoshioka , Akihiko Kitoh , Tomoko Shima , Kajsa Wing , Akira Niwa , Christophe Parizot , Cécile Taflin , Toshio Heike , Dominique Valeyre , Alexis Mathian , Tatsutoshi Nakahata , Tomoyuki Yamaguchi , Takashi Nomura , Masahiro Ono , Zahir Amoura , Guy Gorochov , Shimon Sakaguchi

Affiliations

¹ Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

PMID: 19464196
863 citations

Abstract

FoxP3 is a key transcription factor for the development and function of natural CD4(+) regulatory T cells (Treg cells). Here we show that human FoxP3(+)CD4(+) T cells were composed of three phenotypically and functionally distinct subpopulations: CD45RA(+)FoxP3(lo) resting Treg cells (rTreg cells) and CD45RA(-)FoxP3(hi) activated Treg cells (aTreg cells), both of which were suppressive in vitro, and cytokine-secreting CD45RA(-)FoxP3(lo) nonsuppressive T cells. The proportion of the three subpopulations differed between cord blood, aged individuals, and patients with immunological diseases. Terminally differentiated aTreg cells rapidly died whereas rTreg cells proliferated and converted into aTreg cells in vitro and in vivo. This was shown by the transfer of rTreg cells into NOD-scid-common gamma-chain-deficient mice and by TCR sequence-based T cell clonotype tracing in peripheral blood in a normal individual. Taken together, the dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP3(+) subpopulations.

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Cellular and molecular determinants for the development of natural and induced regulatory T cells. Xiaomei Yuan, Thomas R Malek. Hum Immunol, 2012 Jun 05; 73(8). PMID: 22659217 Free PMC article. Review.
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Ashish K Marwaha, Nicole J Leung, Alicia N McMurchy, Megan K Levings. Front Immunol, 2012 Jun 08; 3. PMID: 22675324 Free PMC article.
Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates. A Aoyama, D Klarin, +8 authors, T Kawai. less Am J Transplant, 2012 Jun 12; 12(9). PMID: 22682297 Free PMC article.
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation? Francisco Salcido-Ochoa, Nurhashikin Yusof, +3 authors, Olaf Rotzschke. less J Transplant, 2012 Jun 13; 2012. PMID: 22690325 Free PMC article.
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation. Pervinder Sagoo, Giovanna Lombardi, Robert I Lechler. Front Immunol, 2012 Jul 20; 3. PMID: 22811678 Free PMC article.
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. Mathieu Angin, Melanie King, +3 authors, Marylyn M Addo. less AIDS, 2012 Aug 10; 26(16). PMID: 22874519 Free PMC article.
Translating tolerogenic therapies to the clinic - where do we stand? Fadi Issa, Kathryn J Wood. Front Immunol, 2012 Aug 31; 3. PMID: 22934094 Free PMC article.
Subpopulations of regulatory T cells in rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease. Jae-Ryong Kim, Jin-Nyeong Chae, Sang-Hyon Kim, Jung-Sook Ha. J Korean Med Sci, 2012 Sep 13; 27(9). PMID: 22969245 Free PMC article.
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation. Hanna Bendfeldt, Manuela Benary, +4 authors, Ria Baumgrass. less Front Immunol, 2012 Sep 13; 3. PMID: 22969764 Free PMC article.
De Novo Donor-Specific HLA Antibody Development and Peripheral CD4(+)CD25(high) Cells in Kidney Transplant Recipients: A Place for Interaction? Josefina Alberu, Maria Inés Vargas-Rojas, +6 authors, Jorge Alcocer-Varela. less J Transplant, 2012 Sep 13; 2012. PMID: 22970343 Free PMC article.
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Jacques Banchereau, Virginia Pascual, Anne O'Garra. Nat Immunol, 2012 Sep 20; 13(10). PMID: 22990890 Free PMC article. Highly Cited. Review.
Basic principles of tumor-associated regulatory T cell biology. Peter A Savage, Sven Malchow, Daniel S Leventhal. Trends Immunol, 2012 Sep 25; 34(1). PMID: 22999714 Free PMC article. Review.
An optimized multi-parameter flow cytometry protocol for human T regulatory cell analysis on fresh and viably frozen cells, correlation with epigenetic analysis, and comparison of cord and adult blood. L Nettenstrom, K Alderson, +4 authors, C M Seroogy. less J Immunol Methods, 2012 Oct 13; 387(1-2). PMID: 23058673 Free PMC article.
Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells. Nuno Costa, Ana E Pires, +18 authors, Constantin Fesel. less J Clin Immunol, 2012 Oct 16; 33(2). PMID: 23064977
Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. Karthick Raja Muthu Raja, Lucie Rihova, +3 authors, Roman Hajek. less PLoS One, 2012 Oct 17; 7(10). PMID: 23071717 Free PMC article.
Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis. Valérie Faivre, Anne Claire Lukaszewicz, +3 authors, Alain Haziot. less PLoS One, 2012 Oct 17; 7(10). PMID: 23071758 Free PMC article.
Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Benjamin Terrier, Nicolas Derian, +13 authors, Nathalie Costedoat-Chalumeau. less Arthritis Res Ther, 2012 Oct 19; 14(5). PMID: 23075451 Free PMC article.
Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma. Serena K Perna, Biagio De Angelis, +8 authors, Barbara Savoldo. less Clin Cancer Res, 2012 Nov 15; 19(1). PMID: 23149818 Free PMC article.
Interleukin-2 treatment of tumor patients can expand regulatory T cells. Marc Beyer. Oncoimmunology, 2012 Nov 22; 1(7). PMID: 23170272 Free PMC article.
Suppression, subversion and escape: the role of regulatory T cells in cancer progression. K Oleinika, R J Nibbs, G J Graham, A R Fraser. Clin Exp Immunol, 2012 Dec 04; 171(1). PMID: 23199321 Free PMC article. Review.
Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Nichole R Blatner, Mary F Mulcahy, +21 authors, Khashayarsha Khazaie. less Sci Transl Med, 2012 Dec 18; 4(164). PMID: 23241743 Free PMC article. Highly Cited.
Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Cristiano Scottà, Marianna Esposito, +9 authors, Giovanna Lombardi. less Haematologica, 2012 Dec 18; 98(8). PMID: 23242600 Free PMC article.
Regulatory T cells in HIV infection: can immunotherapy regulate the regulator? Mohammad-Ali Jenabian, Petronela Ancuta, Norbert Gilmore, Jean-Pierre Routy. Clin Dev Immunol, 2012 Dec 20; 2012. PMID: 23251223 Free PMC article. Review.
Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application. Sya N Ukena, Sarvari Velaga, +5 authors, Anke Franzke. less PLoS One, 2012 Dec 20; 7(12). PMID: 23251603 Free PMC article.
Functional defect in regulatory T cells in myasthenia gravis. Muthusamy Thiruppathi, Julie Rowin, +3 authors, Matthew N Meriggioli. less Ann N Y Acad Sci, 2012 Dec 21; 1274. PMID: 23252899 Free PMC article. Review.
Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy. James B Canavan, Behdad Afzali, Graham M Lord, Giovanna Lombardi. Expert Rev Mol Diagn, 2012 Dec 22; 13(1). PMID: 23256698 Free PMC article.
Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells. Kate Milward, Fadi Issa, +3 authors, Kathryn J Wood. less Transplantation, 2012 Dec 25; 95(1). PMID: 23263503 Free PMC article.
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Harald von Boehmer, Carolin Daniel. Nat Rev Drug Discov, 2013 Jan 01; 12(1). PMID: 23274471 Highly Cited. Review.
Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells. Gina J Walter, Hayley G Evans, +5 authors, Leonie S Taams. less Arthritis Rheum, 2013 Jan 03; 65(3). PMID: 23280063 Free PMC article.
Analysis of suppressor and non-suppressor FOXP3+ T cells in HIV-1-infected patients. Lourdes Arruvito, Juan Sabatté, +6 authors, Leonardo Fainboim. less PLoS One, 2013 Jan 04; 7(12). PMID: 23285102 Free PMC article.
Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model. Fadi Issa, Joanna Hester, Kate Milward, Kathryn J Wood. PLoS One, 2013 Jan 10; 7(12). PMID: 23300911 Free PMC article.
Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults. Cheryl L Day, Michele Tameris, +19 authors, Willem A Hanekom. less Am J Respir Crit Care Med, 2013 Jan 12; 188(4). PMID: 23306546 Free PMC article.
Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. J Wisniewski, R Agrawal, J A Woodfolk. Clin Exp Allergy, 2013 Jan 22; 43(2). PMID: 23331558 Free PMC article. Review.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Dietmar M W Zaiss, Jorg van Loosdregt, +7 authors, Alice J A M Sijts. less Immunity, 2013 Jan 22; 38(2). PMID: 23333074 Free PMC article. Highly Cited.
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Torkel Vang, Johannes Landskron, +7 authors, Benedicte A Lie. less Hum Immunol, 2013 Jan 22; 74(5). PMID: 23333624 Free PMC article.
CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines. Anne M Pesenacker, David Bending, +3 authors, Simona Ursu, Qiong Wu, Kiran Nistala, Lucy R Wedderburn. less Blood, 2013 Jan 29; 121(14). PMID: 23355538 Free PMC article.
Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis. Hui Yin, Xiangyong Li, +5 authors, Hongbiao Gu. less Immunology, 2013 Mar 14; 139(4). PMID: 23480027 Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Mark J Dobrzanski. Front Oncol, 2013 Mar 28; 3. PMID: 23533029 Free PMC article.
Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. Iris K Gratz, Hong-An Truong, +4 authors, Michael D Rosenblum. less J Immunol, 2013 Apr 02; 190(9). PMID: 23543753 Free PMC article.
Regulatory T-cell immunotherapy for allogeneic hematopoietic stem-cell transplantation. Matthew Horch, Vu H Nguyen. Ther Adv Hematol, 2012 Feb 01; 3(1). PMID: 23556110 Free PMC article.
Promoting transplantation tolerance; adoptive regulatory T cell therapy. N Safinia, J Leech, +2 authors, M Hernandez-Fuentes, R Lechler, G Lombardi. less Clin Exp Immunol, 2013 Apr 12; 172(2). PMID: 23574313 Free PMC article. Review.
Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Ricardo S Paiva, Andreia C Lino, +4 authors, Jocelyne Demengeot. less Proc Natl Acad Sci U S A, 2013 Apr 12; 110(16). PMID: 23576744 Free PMC article.
Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation. Behdad Afzali, Francis C Edozie, +11 authors, Giovanna Lombardi. less Clin J Am Soc Nephrol, 2013 Apr 13; 8(8). PMID: 23580782 Free PMC article.
Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response. Chiara Camisaschi, Paola Filipazzi, +19 authors, Chiara Castelli. less Cancer Immunol Immunother, 2013 Apr 17; 62(5). PMID: 23589107 Free PMC article.
Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. J B Bollyky, S A Long, +8 authors, C J Greenbaum. less Clin Exp Immunol, 2013 Apr 23; 172(3). PMID: 23600824 Free PMC article.
CD4⁺ CD45RA⁻ FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes. F Haseda, A Imagawa, +2 authors, Y Murase-Mishiba, J Terasaki, T Hanafusa. less Clin Exp Immunol, 2013 Apr 24; 173(2). PMID: 23607886 Free PMC article.
Decreases in the numbers of peripheral blood regulatory T cells, and increases in the levels of memory and activated B cells, in patients with active eosinophilic granulomatosis and polyangiitis. Naomi Tsurikisawa, Hiroshi Saito, +2 authors, Chiyako Oshikata, Takahiro Tsuburai, Kazuo Akiyama. less J Clin Immunol, 2013 Apr 30; 33(5). PMID: 23624693
Induced and natural regulatory T cells in the development of inflammatory bowel disease. Christopher G Mayne, Calvin B Williams. Inflamm Bowel Dis, 2013 May 10; 19(8). PMID: 23656897 Free PMC article. Review.
Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes. Yohko Kitagawa, Naganari Ohkura, Shimon Sakaguchi. Front Immunol, 2013 May 16; 4. PMID: 23675373 Free PMC article.
CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Behdad Afzali, Peter J Mitchell, +18 authors, Giovanna Lombardi. less Eur J Immunol, 2013 May 17; 43(8). PMID: 23677517 Free PMC article.
The plasticity and stability of regulatory T cells. Shimon Sakaguchi, Dario A A Vignali, +2 authors, Alexander Y Rudensky, Rachel E Niec, Herman Waldmann. less Nat Rev Immunol, 2013 May 18; 13(6). PMID: 23681097 Highly Cited.
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Esther Bandala-Sanchez, Yuxia Zhang, +5 authors, Leonard C Harrison. less Nat Immunol, 2013 May 21; 14(7). PMID: 23685786
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells. R Goto, S You, +2 authors, M Zaitsu, L Chatenoud, K J Wood. less Am J Transplant, 2013 Jun 12; 13(7). PMID: 23750800 Free PMC article.
Urinary trypsin inhibitor attenuated inflammatory response of patients undergoing cardiopulmonary bypass by inducing activated Treg cells. Xing Hao, Junyan Han, +5 authors, Xiaotong Hou. less Inflammation, 2013 Jun 15; 36(6). PMID: 23765601
The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Lequn Li, Vassiliki A Boussiotis. Clin Immunol, 2013 Jun 19; 148(2). PMID: 23773923 Free PMC article. Review.
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. Xinjuan Liu, Na Gao, +7 authors, Xiaofeng Zeng. less PLoS One, 2013 Jun 19; 8(6). PMID: 23776439 Free PMC article.
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. Chunyan Gu-Trantien, Sherene Loi, +21 authors, Karen Willard-Gallo. less J Clin Invest, 2013 Jun 20; 123(7). PMID: 23778140 Free PMC article. Highly Cited.
Innate immune responses in the CNS: role of toll-like receptors, mechanisms, and therapeutic opportunities in multiple sclerosis. Giulio Podda, Mukanthu Nyirenda, James Crooks, Bruno Gran. J Neuroimmune Pharmacol, 2013 Jul 03; 8(4). PMID: 23812895 Review.
Thymic versus induced regulatory T cells - who regulates the regulators? Giovanni Antonio Maria Povoleri, Cristiano Scottà, +3 authors, Behdad Afzali. less Front Immunol, 2013 Jul 03; 4. PMID: 23818888 Free PMC article.
Treg and CTLA-4: two intertwining pathways to immune tolerance. Lucy S K Walker. J Autoimmun, 2013 Jul 16; 45. PMID: 23849743 Free PMC article. Highly Cited. Review.
Natural and induced T regulatory cells in cancer. Dennis O Adeegbe, Hiroyoshi Nishikawa. Front Immunol, 2013 Jul 23; 4. PMID: 23874336 Free PMC article. Highly Cited.
TGFβ receptor mutations impose a strong predisposition for human allergic disease. Pamela A Frischmeyer-Guerrerio, Anthony L Guerrerio, +6 authors, Harry C Dietz. less Sci Transl Med, 2013 Jul 26; 5(195). PMID: 23884466 Free PMC article. Highly Cited.
Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive? Song Guo Zheng. Am J Clin Exp Immunol, 2013 Jul 26; 2(1). PMID: 23885327 Free PMC article.
CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection. Federico Simonetta, Christine Bourgeois. Front Immunol, 2013 Aug 03; 4. PMID: 23908654 Free PMC article.
The percentage of FoxP3+Helios+ Treg cells correlates positively with disease activity in systemic lupus erythematosus. Amit Golding, Sarfaraz Hasni, Gabor Illei, Ethan M Shevach. Arthritis Rheum, 2013 Aug 09; 65(11). PMID: 23925905 Free PMC article.
Peripherally induced tregs - role in immune homeostasis and autoimmunity. Mahesh Yadav, Stephen Stephan, Jeffrey A Bluestone. Front Immunol, 2013 Aug 24; 4. PMID: 23966994 Free PMC article. Highly Cited.
Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells. Yuxia Zhang, Jovana Maksimovic, +5 authors, Leonard C Harrison. less Blood, 2013 Aug 27; 122(16). PMID: 23974203 Free PMC article.
Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer. Alessia Burocchi, Mario P Colombo, Silvia Piconese. Front Immunol, 2013 Aug 30; 4. PMID: 23986759 Free PMC article.
Autoantibodies to estrogen receptor α in systemic sclerosis (SSc) as pathogenetic determinants and markers of progression. Antonello Giovannetti, Angela Maselli, +7 authors, Marina Pierdominici. less PLoS One, 2013 Sep 24; 8(9). PMID: 24058548 Free PMC article.
Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells. M Scurr, K Ladell, +10 authors, A Godkin. less Mucosal Immunol, 2013 Sep 26; 7(2). PMID: 24064667 Free PMC article.
HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. Nanae Yamamoto-Taguchi, Yorifumi Satou, +5 authors, Masao Matsuoka. less PLoS Pathog, 2013 Sep 27; 9(9). PMID: 24068936 Free PMC article.
Genetic variants regulating immune cell levels in health and disease. Valeria Orrù, Maristella Steri, +49 authors, Francesco Cucca. less Cell, 2013 Oct 01; 155(1). PMID: 24074872 Free PMC article. Highly Cited.
MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development. Katie Podshivalova, Daniel R Salomon. Crit Rev Immunol, 2013 Oct 09; 33(5). PMID: 24099302 Free PMC article. Review.
Human APECED; a Sick Thymus Syndrome? T Petteri Arstila, Hanna Jarva. Front Immunol, 2013 Oct 11; 4. PMID: 24109480 Free PMC article. Review.
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Daisuke Sugiyama, Hiroyoshi Nishikawa, +10 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2013 Oct 16; 110(44). PMID: 24127572 Free PMC article. Highly Cited.
Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions. Haiqi He, Bing Ni, +6 authors, Yong Zhang. less Immunology, 2013 Oct 25; 141(3). PMID: 24152290 Free PMC article.
Regulatory T-cell therapy in transplantation: moving to the clinic. Qizhi Tang, Jeffrey A Bluestone. Cold Spring Harb Perspect Med, 2013 Nov 05; 3(11). PMID: 24186492 Free PMC article. Highly Cited. Review.
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. Stephen W Scally, Jan Petersen, +14 authors, Jamie Rossjohn. less J Exp Med, 2013 Nov 06; 210(12). PMID: 24190431 Free PMC article. Highly Cited.
Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity. Li Zhang, Anne M Bertucci, +3 authors, Syamal K Datta. less Clin Immunol, 2013 Nov 12; 149(3). PMID: 24211843 Free PMC article.
Immunotherapy: shifting the balance of cell-mediated immunity and suppression in human prostate cancer. Jo A Tucker, Caroline Jochems, +2 authors, James L Gulley, Jeffrey Schlom, Kwong Y Tsang. less Cancers (Basel), 2012 Jan 01; 4(4). PMID: 24213509 Free PMC article.
Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Christopher G Kanakry, Sudipto Ganguly, +7 authors, Leo Luznik. less Sci Transl Med, 2013 Nov 15; 5(211). PMID: 24225944 Free PMC article. Highly Cited.
Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy. Camila Fernandes, Heitor Sá Gonçalves, +3 authors, Lilia Maria Carneiro Câmara. less PLoS One, 2013 Nov 19; 8(11). PMID: 24244424 Free PMC article.
Distribution of CD4(pos) -, CD8(pos) - and regulatory T cells in the upper and lower gastrointestinal tract in healthy young subjects. Martin Tauschmann, Barbara Prietl, +4 authors, Thomas R Pieber. less PLoS One, 2013 Nov 23; 8(11). PMID: 24265815 Free PMC article.
IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. Geok Choo Sim, Natalia Martin-Orozco, +9 authors, Laszlo Radvanyi. less J Clin Invest, 2013 Dec 03; 124(1). PMID: 24292706 Free PMC article. Highly Cited.
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. M Kathryn Liszewski, Martin Kolev, +16 authors, Claudia Kemper. less Immunity, 2013 Dec 10; 39(6). PMID: 24315997 Free PMC article. Highly Cited.
HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo. Kei Sato, Naoko Misawa, +7 authors, Yoshio Koyanagi. less PLoS Pathog, 2013 Dec 18; 9(12). PMID: 24339781 Free PMC article.
Efficient expansion of cryopreserved CD4(+)CD25(+)CD127(lo/-) cells in Type 1 diabetes. Anna Rydén, Maria Faresjö. Results Immunol, 2011 Jan 01; 1(1). PMID: 24371551 Free PMC article.
Detection of Foreign Antigen-specific CD4(+)Foxp3(+) Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining. Jin Young Choi, Seong Kug Eo. Immune Netw, 2014 Jan 05; 13(6). PMID: 24385945 Free PMC article.
Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs. K Smigielska-Czepiel, A van den Berg, +6 authors, B-J Kroesen. less Genes Immun, 2014 Jan 10; 15(2). PMID: 24401767 Free PMC article.
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy. Jagadeesh Bayry. Virusdisease, 2014 Jan 16; 25(1). PMID: 24426307 Free PMC article. Review.
Increase in TGF-β secreting CD4⁺CD25⁺ FOXP3⁺ T regulatory cells in anergic lepromatous leprosy patients. Chaman Saini, Venkatesh Ramesh, Indira Nath. PLoS Negl Trop Dis, 2014 Jan 24; 8(1). PMID: 24454972 Free PMC article.
Immune modulation in humans: implications for type 1 diabetes mellitus. Bart O Roep, Timothy I M Tree. Nat Rev Endocrinol, 2014 Jan 29; 10(4). PMID: 24468651 Review.
Homeostatic control of regulatory T cell diversity. Adrian Liston, Daniel H D Gray. Nat Rev Immunol, 2014 Feb 01; 14(3). PMID: 24481337 Highly Cited. Review.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. Mathieu Angin, Paul L Klarenbeek, +10 authors, Marylyn M Addo. less PLoS One, 2014 Feb 06; 9(2). PMID: 24498287 Free PMC article.
Memory regulatory T cells reside in human skin. Robert Sanchez Rodriguez, Mariela L Pauli, +29 authors, Michael D Rosenblum. less J Clin Invest, 2014 Feb 11; 124(3). PMID: 24509084 Free PMC article. Highly Cited.
Engineering human peripheral blood stem cell grafts that are depleted of naïve T cells and retain functional pathogen-specific memory T cells. Marie Bleakley, Shelly Heimfeld, +4 authors, Warren Shlomchik. less Biol Blood Marrow Transplant, 2014 Feb 15; 20(5). PMID: 24525279 Free PMC article.
Comparative analysis of FoxP3(+) regulatory T cells in the target tissues and blood in chronic graft versus host disease. M M Imanguli, E W Cowen, +7 authors, F T Hakim. less Leukemia, 2014 Mar 01; 28(10). PMID: 24577531 Free PMC article.
Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2rγnull mice. Fang Xiao, Liang Ma, +5 authors, Giovanna Lombardi. less PLoS One, 2014 Mar 07; 9(3). PMID: 24594640 Free PMC article.
Th1 response and systemic treg deficiency in inclusion body myositis. Yves Allenbach, Wahiba Chaara, +14 authors, Olivier Benveniste. less PLoS One, 2014 Mar 07; 9(3). PMID: 24594700 Free PMC article.
Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis. W A Goodman, R R Garg, +3 authors, B K Reuter, B Mattioli, E F Rissman, T T Pizarro. less Mucosal Immunol, 2014 Mar 14; 7(5). PMID: 24621993 Free PMC article.
Modulation of Regulatory T-Cell Subsets in Very Long-Term Treated Aviremic HIV(+) Patients and Untreated Viremic Patients. Federico Serana, Marco Chiarini, +6 authors, Luisa Imberti. less Open AIDS J, 2014 Mar 15; 8. PMID: 24627733 Free PMC article.
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). Aleena Syed, Marco A Garcia, +9 authors, Kari C Nadeau. less J Allergy Clin Immunol, 2014 Mar 19; 133(2). PMID: 24636474 Free PMC article. Highly Cited.
The intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic clues. A Ling, S Edin, +2 authors, M L Wikberg, Å Öberg, R Palmqvist. less Br J Cancer, 2014 Mar 29; 110(10). PMID: 24675384 Free PMC article.
Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis. Hardis Rabe, Inger Nordström, +2 authors, Anna Rudin. less Immunology, 2014 Apr 09; 141(3). PMID: 24708420 Free PMC article.
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs. Kesley Attridge, Lucy S K Walker. Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712457 Free PMC article. Review.
Treg functional stability and its responsiveness to the microenvironment. Joseph Barbi, Drew Pardoll, Fan Pan. Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712463 Free PMC article. Review.
Once a Treg, always a Treg? Deepali V Sawant, Dario A A Vignali. Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712466 Free PMC article. Highly Cited. Review.
Regulatory T cells in autoimmune neuroinflammation. Markus Kleinewietfeld, David A Hafler. Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712469 Free PMC article. Highly Cited. Review.
Molecular signatures differentiate immune states in type 1 diabetic families. Yi-Guang Chen, Susanne M Cabrera, +9 authors, Martin J Hessner. less Diabetes, 2014 Apr 25; 63(11). PMID: 24760139 Free PMC article.
CD45RA-Foxp3high but not CD45RA+Foxp3low suppressive T regulatory cells increased in the peripheral circulation of patients with head and neck squamous cell carcinoma and correlated with tumor progression. Wei Sun, Wei-Jin Li, +2 authors, Chang-You Wu, Hua Zhong, Wei-Ping Wen. less J Exp Clin Cancer Res, 2014 Apr 26; 33. PMID: 24761979 Free PMC article.
Selective targeting of Toll-like receptors and OX40 inhibit regulatory T-cell function in follicular lymphoma. Kui Shin Voo, Myriam Foglietta, +13 authors, Sattva S Neelapu. less Int J Cancer, 2014 Apr 29; 135(12). PMID: 24771328 Free PMC article.
Ubiquitous points of control over regulatory T cells. Fan Pan, Joseph Barbi. J Mol Med (Berl), 2014 Apr 30; 92(6). PMID: 24777637 Free PMC article. Review.
Gut microbiota and the paradox of cancer immunotherapy. Theofilos Poutahidis, Markus Kleinewietfeld, Susan E Erdman. Front Immunol, 2014 Apr 30; 5. PMID: 24778636 Free PMC article. Review.
Regulatory T cells and their roles in immune dysregulation and allergy. Laurence Pellerin, Jennifer A Jenks, +2 authors, Philippe Bégin, Rosa Bacchetta, Kari C Nadeau. less Immunol Res, 2014 May 02; 58(2-3). PMID: 24781194 Free PMC article. Review.
Reconstitution of regulatory T-cell subsets after allogeneic hematopoietic SCT. A Xhaard, H Moins-Teisserenc, +10 authors, G Socié. less Bone Marrow Transplant, 2014 May 21; 49(8). PMID: 24842524
Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs. Monique R Anderson, Yoshimi Enose-Akahata, +4 authors, Steven Jacobson. less J Neuroimmune Pharmacol, 2014 May 23; 9(4). PMID: 24845974 Free PMC article.
Normal human pregnancy results in maternal immune activation in the periphery and at the uteroplacental interface. Andrea I Loewendorf, Tina A Nguyen, Maria N Yesayan, Daniel A Kahn. PLoS One, 2014 May 23; 9(5). PMID: 24846312 Free PMC article.
Selective depletion of regulatory T cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer. Jie-Yao Li, Xiu-Fang Duan, +10 authors, Yi Zhang. less J Immunol Res, 2014 May 29; 2014. PMID: 24868562 Free PMC article.
Ontogeny of early life immunity. David J Dowling, Ofer Levy. Trends Immunol, 2014 Jun 02; 35(7). PMID: 24880460 Free PMC article. Highly Cited. Review.
Administration of a nondepleting anti-CD25 monoclonal antibody reduces disease severity in mice infected with Trypanosoma cruzi. J Nihei, F Cardillo, +2 authors, J Mengel. less Eur J Microbiol Immunol (Bp), 2014 Jun 03; 4(2). PMID: 24883199 Free PMC article.
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory. Anna Okhrimenko, Joachim R Grün, +16 authors, Jun Dong. less Proc Natl Acad Sci U S A, 2014 Jun 14; 111(25). PMID: 24927527 Free PMC article. Highly Cited.
Induced regulatory T cells in inhibitory microenvironments created by cancer. Theresa L Whiteside. Expert Opin Biol Ther, 2014 Jun 18; 14(10). PMID: 24934899 Free PMC article. Review.
Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Changhua Zhuo, Zhiyuan Li, +7 authors, Sanjun Cai. less Mol Cancer, 2014 Jun 19; 13. PMID: 24938080 Free PMC article.
Linking T-cell receptor sequence to functional phenotype at the single-cell level. Arnold Han, Jacob Glanville, Leo Hansmann, Mark M Davis. Nat Biotechnol, 2014 Jun 24; 32(7). PMID: 24952902 Free PMC article. Highly Cited.
TREG-cell therapies for autoimmune rheumatic diseases. Makoto Miyara, Yoshinaga Ito, Shimon Sakaguchi. Nat Rev Rheumatol, 2014 Jul 02; 10(9). PMID: 24980140 Highly Cited. Review.
Gut commensalism, cytokines, and central nervous system demyelination. Kiel Telesford, Javier Ochoa-Repáraz, Lloyd H Kasper. J Interferon Cytokine Res, 2014 Aug 02; 34(8). PMID: 25084177 Free PMC article. Review.
Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Ling Lu, Qin Lan, +15 authors, Song Guo Zheng. less Proc Natl Acad Sci U S A, 2014 Aug 08; 111(33). PMID: 25099355 Free PMC article. Highly Cited.
A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer. Gang Chen, Richa Gupta, +18 authors, Leisha A Emens. less Cancer Immunol Res, 2014 Aug 15; 2(10). PMID: 25116755 Free PMC article.
Innate-like and conventional T cell populations from hemodialyzed and kidney transplanted patients are equally compromised. Marine Baron, Renata Belo, +5 authors, Maria Leite-de-Moraes. less PLoS One, 2014 Aug 22; 9(8). PMID: 25144742 Free PMC article.
Immunological barriers to stem cell therapy in the central nervous system. Gregory E Tullis, Kathleen Spears, Mark D Kirk. Stem Cells Int, 2014 Aug 29; 2014. PMID: 25165476 Free PMC article. Review.
An increase of CD83+ dendritic cells ex vivo correlates with increased regulatory T cells in patients with active eosinophilic granulomatosis and polyangiitis. Naomi Tsurikisawa, Hiroshi Saito, +4 authors, Kazuo Akiyama. less BMC Immunol, 2014 Sep 02; 15. PMID: 25174446 Free PMC article.
Frequencies of CD4+ T Regulatory Cells and their CD25(high) and FoxP3(high) Subsets Augment in Peripheral Blood of Patients with Acute and Chronic Brucellosis. Abbas Bahador, Jamshid Hadjati, +5 authors, Amirhooshang Nejadeh. less Osong Public Health Res Perspect, 2014 Sep 03; 5(3). PMID: 25180149 Free PMC article.
Immune reaction and colorectal cancer: friends or foes? Vincenzo Formica, Vittore Cereda, +2 authors, Mario Roselli. less World J Gastroenterol, 2014 Sep 26; 20(35). PMID: 25253941 Free PMC article. Review.
CD4⁺ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer. Jayashri Mahalingam, Chun-Yen Lin, +6 authors, Yung-Chang Lin. less PLoS One, 2014 Oct 01; 9(9). PMID: 25268580 Free PMC article.
1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. Tom L Van Belle, An-Sofie Vanherwegen, +5 authors, Chantal Mathieu. less PLoS One, 2014 Oct 04; 9(10). PMID: 25279717 Free PMC article.
Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma. Marie-Andrée Forget, Shruti Malu, +11 authors, Laszlo G Radvanyi. less J Immunother, 2014 Oct 12; 37(9). PMID: 25304728 Free PMC article.
Targeting regulatory T cells to improve vaccine immunogenicity in early life. Jorjoh Ndure, Katie L Flanagan. Front Microbiol, 2014 Oct 14; 5. PMID: 25309517 Free PMC article. Review.
Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Marie Tosolini, Frédéric Pont, +9 authors, Jean-Jacques Fournié. less Mol Cell Biol, 2014 Nov 12; 35(2). PMID: 25384972 Free PMC article.
Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease. K Åkesson, A Tompa, A Rydén, M Faresjö. Clin Exp Immunol, 2014 Nov 26; 180(1). PMID: 25421756 Free PMC article.
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. Maura Rossetti, Roberto Spreafico, +7 authors, Salvatore Albani. less J Immunol, 2014 Dec 03; 194(1). PMID: 25452562 Free PMC article.
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. Charles J M Bell, Yongliang Sun, +13 authors, Laurence B Peterson. less J Autoimmun, 2014 Dec 03; 56. PMID: 25457307 Free PMC article.
Antiretroviral Pre-Exposure Prophylaxis Does Not Enhance Immune Responses to HIV in Exposed but Uninfected Persons. Laura Pattacini, Pamela M Murnane, +12 authors, Partners PrEP Study Team. less J Infect Dis, 2014 Dec 19; 211(12). PMID: 25520426 Free PMC article.
Control of the inflammatory response mechanisms mediated by natural and induced regulatory T-cells in HCV-, HTLV-1-, and EBV-associated cancers. Laurissa Ouaguia, Dhafer Mrizak, +2 authors, Sarah Renaud, Olivier Moralès, Nadira Delhem. less Mediators Inflamm, 2014 Dec 20; 2014. PMID: 25525301 Free PMC article. Review.
Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance. Faouzi Braza, Emilie Dugast, +14 authors, Sophie Brouard. less J Am Soc Nephrol, 2015 Jan 04; 26(8). PMID: 25556168 Free PMC article.
FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer. Changhua Zhuo, Ye Xu, +5 authors, Bin Li. less Immunol Res, 2015 Jan 23; 61(3). PMID: 25608795 Review.
The complex pathophysiology of acquired aplastic anaemia. Y Zeng, E Katsanis. Clin Exp Immunol, 2015 Feb 17; 180(3). PMID: 25683099 Free PMC article. Review.
FOXP3+ regulatory T cells and their functional regulation. Zhiyuan Li, Dan Li, Andy Tsun, Bin Li. Cell Mol Immunol, 2015 Feb 17; 12(5). PMID: 25683611 Free PMC article. Review.
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Tomohisa Okamura, Shuji Sumitomo, +8 authors, Kazuhiko Yamamoto. less Nat Commun, 2015 Feb 20; 6. PMID: 25695838 Free PMC article.
Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease. James B Canavan, Cristiano Scottà, +18 authors, Graham M Lord. less Gut, 2015 Feb 26; 65(4). PMID: 25715355 Free PMC article.
Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Takashi Ishida, Tatsuro Jo, +18 authors, Ryuzo Ueda. less Br J Haematol, 2015 Mar 04; 169(5). PMID: 25733162 Free PMC article. Highly Cited.
Tregs in gliomas - the jury is still out. Michael Platten, Wolfgang Wick. Neuro Oncol, 2015 Mar 11; 17(6). PMID: 25754090 Free PMC article.
Impacts of humanized mouse models on the investigation of HIV-1 infection: illuminating the roles of viral accessory proteins in vivo. Eri Yamada, Rokusuke Yoshikawa, +3 authors, Kei Sato. less Viruses, 2015 Mar 26; 7(3). PMID: 25807049 Free PMC article. Review.
Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity. Vedran Brezar, Nicolas Ruffin, +7 authors, Nabila Seddiki. less PLoS Pathog, 2015 Mar 31; 11(3). PMID: 25816350 Free PMC article.
Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Jane C Burns, Ranim Touma, +5 authors, Alessandra Franco. less Autoimmunity, 2015 Mar 31; 48(3). PMID: 25822882 Free PMC article.
Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients. Jithendra Kini Bailur, Brigitte Gueckel, Evelyna Derhovanessian, Graham Pawelec. Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849846 Free PMC article.
The ontogeny of naïve and regulatory CD4(+) T-cell subsets during the first postnatal year: a cohort study. Fiona M Collier, Mimi L K Tang, +8 authors, Anne-Louise Ponsonby. less Clin Transl Immunology, 2015 Apr 11; 4(3). PMID: 25859389 Free PMC article.
Regulation of human helper T cell subset differentiation by cytokines. Nathalie Schmitt, Hideki Ueno. Curr Opin Immunol, 2015 Apr 17; 34. PMID: 25879814 Free PMC article. Highly Cited. Review.
Role of regulatory T cell in clinical outcome of traumatic brain injury. Min Li, Yun-Peng Lin, +3 authors, Jie-Li Chen, Hong Li, Rong-Cai Jiang, Jian-Ning Zhang. less Chin Med J (Engl), 2015 Apr 18; 128(8). PMID: 25881602 Free PMC article.
Cell therapy to induce allograft tolerance: time to switch to plan B? Antoine Sicard, Alice Koenig, +2 authors, Emmanuel Morelon, Thierry Defrance, Olivier Thaunat. less Front Immunol, 2015 Apr 24; 6. PMID: 25904913 Free PMC article. Review.
Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART. Sandrina DaFonseca, Julia Niessl, +8 authors, Petronela Ancuta. less Retrovirology, 2015 May 01; 12. PMID: 25924895 Free PMC article.
Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors. Nicolas Thiault, Julie Darrigues, +9 authors, Paola Romagnoli. less Nat Immunol, 2015 May 06; 16(6). PMID: 25939024 Highly Cited.
Regulatory T cells turn pathogenic. Jitao Guo, Xuyu Zhou. Cell Mol Immunol, 2015 May 06; 12(5). PMID: 25942597 Free PMC article. Review.
Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent. Christopher G Kanakry, Sudipto Ganguly, Leo Luznik. Oncoimmunology, 2015 May 08; 4(3). PMID: 25949893 Free PMC article.
CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study. Benedikt Fritzsching, Joerg Fellenberg, +13 authors, Pierre Kunz. less Oncoimmunology, 2015 May 08; 4(3). PMID: 25949908 Free PMC article.
Preeclampsia is Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells. Andrea I Loewendorf, Tina A Nguyen, Maria N Yesayan, Daniel A Kahn. Am J Reprod Immunol, 2015 May 13; 74(3). PMID: 25962852 Free PMC article.
Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation. John J Worthington, Aoife Kelly, +4 authors, Mark A Travis. less Immunity, 2015 May 17; 42(5). PMID: 25979421 Free PMC article. Highly Cited.
Innate inflammation in type 1 diabetes. Susanne M Cabrera, Angela M Henschel, Martin J Hessner. Transl Res, 2015 May 20; 167(1). PMID: 25980926 Free PMC article. Review.
Vitamin D deficiency contributes to the reduction and impaired function of naïve CD45RA⁺ regulatory T cell in chronic heart failure. Yan-hui Ma, Yun-lan Zhou, +5 authors, Li-song Shen. less J Immunol Res, 2015 May 20; 2015. PMID: 25984539 Free PMC article.
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans. Kornelis S M van der Geest, Wayel H Abdulahad, +12 authors, Annemieke M H Boots. less Aging Cell, 2015 May 27; 14(5). PMID: 26010129 Free PMC article.
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. Makoto Miyara, Driss Chader, +14 authors, Guy Gorochov. less Proc Natl Acad Sci U S A, 2015 May 28; 112(23). PMID: 26015572 Free PMC article. Highly Cited.
Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Tamara Tilburgs, Ângela C Crespo, +6 authors, Jack L Strominger. less Proc Natl Acad Sci U S A, 2015 May 28; 112(23). PMID: 26015573 Free PMC article. Highly Cited.
Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer. Joseph D Phillips, Lawrence M Knab, +8 authors, Khashayarsha Khazaie. less Cancer Immunol Immunother, 2015 Jun 07; 64(9). PMID: 26047578 Free PMC article.
Ubiquitin-dependent regulation of Foxp3 and Treg function. Joseph Barbi, Drew M Pardoll, Fan Pan. Immunol Rev, 2015 Jun 19; 266(1). PMID: 26085205 Free PMC article. Review.
The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease. Jane C Burns, Alessandra Franco. Expert Rev Clin Immunol, 2015 Jun 24; 11(7). PMID: 26099344 Free PMC article. Review.
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry. Saskia J A M Santegoets, Eveline M Dijkgraaf, +15 authors, Sjoerd H van der Burg. less Cancer Immunol Immunother, 2015 Jul 01; 64(10). PMID: 26122357 Free PMC article. Highly Cited.
New insights into the mechanisms of Treg function. David M Rothstein, Geoffrey Camirand. Curr Opin Organ Transplant, 2015 Jul 01; 20(4). PMID: 26126193 Free PMC article. Review.
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions. Ilaria Grazia Zizzari, Paola Martufi, +6 authors, Chiara Napoletano. less PLoS One, 2015 Jul 07; 10(7). PMID: 26147970 Free PMC article.
The role of the acquired immune response in systemic sclerosis. Carlo Chizzolini, Francesco Boin. Semin Immunopathol, 2015 Jul 15; 37(5). PMID: 26152639 Review.
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells. Pushpa Pandiyan, Jinfang Zhu. Cytokine, 2015 Jul 15; 76(1). PMID: 26165923 Free PMC article. Review.
Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes. Jennie H M Yang, Antony J Cutler, +10 authors, Timothy I M Tree. less Diabetes, 2015 Aug 01; 64(11). PMID: 26224887 Free PMC article.
Increased Galectin-9 Concentration and Number of CD4+Foxp3high+Cells in Bronchoalveolar Lavage Fluid of Patients with Cryptogenic Organizing Pneumonia. Shigeki Katoh, Masaki Ikeda, +5 authors, Mikio Oka. less Lung, 2015 Aug 08; 193(5). PMID: 26249221
Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease. L Hasib, A K Lundberg, +2 authors, H Zachrisson, J Ernerudh, L Jonasson. less J Intern Med, 2015 Aug 12; 279(1). PMID: 26260103 Free PMC article.
High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation. Francisco Boix-Giner, Olga Millan, +14 authors, Manuel Muro. less Int Immunol, 2015 Aug 14; 28(2). PMID: 26270267 Free PMC article.
Regulatory T Cells, Frailty, and Immune Activation in Men Who Have Sex With Men in the Multicenter AIDS Cohort Study. Weiying Zhang, Tricia L Nilles, Jacquett R Johnson, Joseph B Margolick. J Gerontol A Biol Sci Med Sci, 2015 Aug 25; 70(12). PMID: 26297938 Free PMC article.
Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease. James D Lord, Donna M Shows, Janice Chen, Richard C Thirlby. PLoS One, 2015 Aug 26; 10(8). PMID: 26305224 Free PMC article.
Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis. Gina J Walter, Veerle Fleskens, +5 authors, Leonie S Taams. less Arthritis Rheumatol, 2015 Sep 01; 68(1). PMID: 26314565 Free PMC article.
Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension. Yoshiharu Sada, Yoshihiro Dohi, +3 authors, Yasuki Kihara. less Heart Vessels, 2015 Sep 01; 31(8). PMID: 26319442
CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. Raquel Matavele Chissumba, Suse Dayse Silva-Barbosa, +6 authors, Wilson Savino. less BMC Immunol, 2015 Sep 04; 16. PMID: 26329520 Free PMC article.
Impaired survival of regulatory T cells in pulmonary sarcoidosis. Caroline E Broos, Menno van Nimwegen, +9 authors, Bernt van den Blink. less Respir Res, 2015 Sep 18; 16. PMID: 26376720 Free PMC article.
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation. Niloufar Safinia, Cristiano Scotta, +2 authors, Giovanna Lombardi. less Front Immunol, 2015 Sep 18; 6. PMID: 26379673 Free PMC article. Review.
Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis. A Arce-Sillas, D D Álvarez-Luquín, +8 authors, L Adalid-Peralta. less Clin Exp Immunol, 2015 Sep 24; 183(2). PMID: 26391104 Free PMC article.
Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing. Daniel B Rainbow, Xin Yang, +9 authors, Linda S Wicker. less Eur J Immunol, 2015 Oct 01; 45(11). PMID: 26420295 Free PMC article.
Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion. Li-Yuan Chang, Yung-Chang Lin, +10 authors, Chun-Yen Lin. less Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451304 Free PMC article.
TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO. Lingying Ye, Jane C Goodall, +13 authors, Huji Xu. less Immunol Cell Biol, 2015 Oct 16; 94(3). PMID: 26467610
Clinical, immunologic, and genetic characteristics of RAG mutations in 15 Chinese patients with SCID and Omenn syndrome. Xiaoming Bai, Jing Liu, +10 authors, Xiaodong Zhao. less Immunol Res, 2015 Oct 20; 64(2). PMID: 26476733
Genetic and epigenetic variation in the lineage specification of regulatory T cells. Aaron Arvey, Joris van der Veeken, +3 authors, Alexander Y Rudensky. less Elife, 2015 Oct 29; 4. PMID: 26510014 Free PMC article.
Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls. Stefano Pianta, Marta Magatti, +8 authors, Ornella Parolini. less J Cell Mol Med, 2015 Oct 31; 20(1). PMID: 26515425 Free PMC article.
Promises and paradoxes of regulatory T cells in inflammatory bowel disease. James D Lord. World J Gastroenterol, 2015 Nov 03; 21(40). PMID: 26523099 Free PMC article. Review.
Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes. Marija Holcar, Aleš Goropevšek, Alojz Ihan, Tadej Avčin. J Immunol Res, 2015 Nov 04; 2015. PMID: 26525134 Free PMC article.
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors. Nora V Lieske, Kristian Tonby, +2 authors, Dag Kvale, Anne M Dyrhol-Riise, Kjetil Tasken. less PLoS One, 2015 Nov 07; 10(11). PMID: 26544592 Free PMC article.
miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis. Maryam Ahmadian-Elmi, Ali Bidmeshki Pour, +4 authors, Mohammad Hossein Nasr-Esfahani. less Immunogenetics, 2015 Nov 14; 68(1). PMID: 26563334
Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets. Tiffany Caza, Steve Landas. Biomed Res Int, 2015 Nov 20; 2015. PMID: 26583116 Free PMC article. Review.
Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus. Alexis Mathian, Romain Jouenne, +8 authors, Makoto Miyara. less PLoS One, 2015 Dec 03; 10(12). PMID: 26629828 Free PMC article.
PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia. Cristina Peligero, Jordi Argilaguet, +7 authors, Andreas Meyerhans. less PLoS Pathog, 2015 Dec 04; 11(12). PMID: 26633181 Free PMC article.
Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy. Silvia Gregori, Laura Passerini, Maria-Grazia Roncarolo. Front Immunol, 2015 Dec 05; 6. PMID: 26635807 Free PMC article. Review.
Regulatory T-Cell Activity But Not Conventional HIV-Specific T-Cell Responses Are Associated With Protection From HIV-1 Infection. Laura Pattacini, Jared M Baeten, +11 authors, Partners PrEP Study Team. less J Acquir Immune Defic Syndr, 2015 Dec 15; 72(2). PMID: 26656786 Free PMC article.
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets. Grégory Ehx, Muriel Hannon, +2 authors, Frédéric Baron. less Oncotarget, 2015 Dec 15; 6(41). PMID: 26657728 Free PMC article.
Regulatory T cell memory. Michael D Rosenblum, Sing Sing Way, Abul K Abbas. Nat Rev Immunol, 2015 Dec 22; 16(2). PMID: 26688349 Free PMC article. Highly Cited. Review.
Blood-based signatures in type 1 diabetes. Susanne M Cabrera, Yi-Guang Chen, William A Hagopian, Martin J Hessner. Diabetologia, 2015 Dec 25; 59(3). PMID: 26699650 Free PMC article. Review.
CD4+ FOXP3+ Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner Syndrome. Young Ah Lee, Hang-Rae Kim, +9 authors, Sei Won Yang. less PLoS One, 2015 Dec 29; 10(12). PMID: 26709833 Free PMC article.
Immunomodulation with rabbit anti-thymocyte globulin in solid organ transplantation. Giovanbattista Ippoliti, Marco Lucioni, Giuseppe Leonardi, Marco Paulli. World J Transplant, 2016 Jan 02; 5(4). PMID: 26722653 Free PMC article. Review.
FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly. Audrey Romano, Xunya Hou, +15 authors, Alain Dessein. less PLoS Negl Trop Dis, 2016 Jan 06; 10(1). PMID: 26731721 Free PMC article.
Close Encounters of the First Kind: Innate Sensors and Multiple Sclerosis. Lidia Fernández-Paredes, Rebeca Pérez de Diego, Clara de Andrés, Silvia Sánchez-Ramón. Mol Neurobiol, 2016 Jan 07; 54(1). PMID: 26732593 Review.
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Chong T Luo, Will Liao, +2 authors, Saida Dadi, Ahmed Toure, Ming O Li. less Nature, 2016 Jan 21; 529(7587). PMID: 26789248 Free PMC article. Highly Cited.
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases. Christophe Pedros, Fanny Duguet, Abdelhadi Saoudi, Marianne Chabod. World J Gastroenterol, 2016 Jan 27; 22(3). PMID: 26811641 Free PMC article. Review.
Inducing and Administering Tregs to Treat Human Disease. Ana Luisa Perdigoto, Lucienne Chatenoud, Jeffrey A Bluestone, Kevan C Herold. Front Immunol, 2016 Feb 03; 6. PMID: 26834735 Free PMC article. Review.
Regulatory T Cells in Melanoma Revisited by a Computational Clustering of FOXP3+ T Cell Subpopulations. Hiroko Fujii, Julie Josse, +3 authors, Masahiro Ono. less J Immunol, 2016 Feb 13; 196(6). PMID: 26864030 Free PMC article.
Characterization of Regulatory T-Cell Markers in CD4+ T Cells of the Upper Airway Mucosa. Christina Ballke, Einar Gran, Espen S Baekkevold, Frode L Jahnsen. PLoS One, 2016 Feb 13; 11(2). PMID: 26866695 Free PMC article.
Behçet's disease physiopathology: a contemporary review. Mohamad J Zeidan, David Saadoun, +3 authors, Patrice Cacoub. less Auto Immun Highlights, 2016 Feb 13; 7(1). PMID: 26868128 Free PMC article.
Multiplexed tissue biomarker imaging. Edward C Stack, Periklis G Foukas, Peter P Lee. J Immunother Cancer, 2016 Feb 18; 4. PMID: 26885371 Free PMC article.
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism. Yoshiaki Okubo, Heather Torrey, +2 authors, John Butterworth, Hui Zheng, Denise L Faustman. less Clin Transl Immunology, 2016 Feb 24; 5(1). PMID: 26900470 Free PMC article.
Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7. Susana L Silva, Adriana S Albuquerque, +10 authors, Ana E Sousa. less Oncotarget, 2016 Feb 26; 7(11). PMID: 26910841 Free PMC article.
Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy. Claudia Nobrega, Ana Horta, +6 authors, Margarida Correia-Neves. less AIDS, 2016 Feb 27; 30(8). PMID: 26919738 Free PMC article.
T Regulatory Cell Biology in Health and Disease. Fayhan J Alroqi, Talal A Chatila. Curr Allergy Asthma Rep, 2016 Mar 01; 16(4). PMID: 26922942 Free PMC article. Review.
[Regulatory T-cells in systemic lupus erythematosus. IL-2 is decisive for loss of tolerance]. K Ohl, K Tenbrock. Z Rheumatol, 2016 Mar 16; 75(3). PMID: 26975190 Review.
Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets. Kevin H Toomer, Xiaomei Yuan, +3 authors, Jing Yang, Michael J Dee, Aixin Yu, Thomas R Malek. less J Immunol, 2016 Mar 25; 196(9). PMID: 27009492 Free PMC article.
T cell receptor signalling in the control of regulatory T cell differentiation and function. Ming O Li, Alexander Y Rudensky. Nat Rev Immunol, 2016 Mar 31; 16(4). PMID: 27026074 Free PMC article. Highly Cited. Review.
Clinical grade isolation of regulatory T cells from G-CSF mobilized peripheral blood improves with initial depletion of monocytes. Pritesh Patel, Dolores Mahmud, +3 authors, Damiano Rondelli. less Am J Blood Res, 2015 Jan 01; 5(2). PMID: 27069755 Free PMC article.
Development and maintenance of intestinal regulatory T cells. Takeshi Tanoue, Koji Atarashi, Kenya Honda. Nat Rev Immunol, 2016 Apr 19; 16(5). PMID: 27087661 Highly Cited. Review.
Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. Leilei Zhou, Tianyi Cao, +5 authors, Guoyao Tang. less Inflammation, 2016 Apr 24; 39(3). PMID: 27106476
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. Takuro Saito, Hiroyoshi Nishikawa, +19 authors, Shimon Sakaguchi. less Nat Med, 2016 Apr 26; 22(6). PMID: 27111280 Highly Cited.
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients. Amos Kirilovsky, Florence Marliot, +3 authors, Franck Pagès. less Int Immunol, 2016 Apr 29; 28(8). PMID: 27121213 Free PMC article. Highly Cited. Review.
Regulation of Gag- and Env-Specific CD8+ T Cell Responses in ART-Naïve HIV-Infected Patients: Potential Implications for Individualized Immunotherapy. Christian Prebensen, Andreas Lind, Anne-Ma Dyrhol-Riise, Dag Kvale. PLoS One, 2016 Apr 30; 11(4). PMID: 27128502 Free PMC article.
Roles of regulatory T cells in cancer immunity. Yoshiko Takeuchi, Hiroyoshi Nishikawa. Int Immunol, 2016 May 11; 28(8). PMID: 27160722 Free PMC article. Highly Cited. Review.
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab. Alexander Martens, Kilian Wistuba-Hamprecht, +15 authors, Benjamin Weide. less Clin Cancer Res, 2016 May 14; 22(19). PMID: 27169993 Free PMC article. Highly Cited.
Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma. Wei Sun, Wei-Jin Li, +5 authors, Wei-Ping Wen. less Oncotarget, 2016 Oct 23; 7(25). PMID: 27177223 Free PMC article.
Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells. Sangho Lim, Jung-Ah Lee, +3 authors, Je-Min Choi. less PLoS One, 2016 May 18; 11(5). PMID: 27186978 Free PMC article.
Impaired CD8(+) T cell responses upon Toll-like receptor activation in common variable immunodeficiency. Camila de Lollo, Dewton de Moraes Vasconcelos, +5 authors, Maria Notomi Sato. less J Transl Med, 2016 May 18; 14(1). PMID: 27188997 Free PMC article.
The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus. Aleš Goropevšek, Marija Holcar, Tadej Avčin. Clin Rev Allergy Immunol, 2016 May 25; 52(2). PMID: 27216430 Review.
Functional Mechanisms of Treg in the Context of HIV Infection and the Janus Face of Immune Suppression. Jacobo López-Abente, Rafael Correa-Rocha, Marjorie Pion. Front Immunol, 2016 Jun 01; 7. PMID: 27242797 Free PMC article. Review.
Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females. Marieke van der Heiden, Menno C van Zelm, +4 authors, Anne-Marie Buisman. less Sci Rep, 2016 Jun 01; 6. PMID: 27243552 Free PMC article.
Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment. Shahram Kordasti, Benedetta Costantini, +22 authors, Ghulam J Mufti. less Blood, 2016 Jun 10; 128(9). PMID: 27281795 Free PMC article.
TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis. Maura Rossetti, Roberto Spreafico, +11 authors, Salvatore Albani. less Ann Rheum Dis, 2016 Jun 18; 76(2). PMID: 27311837 Free PMC article.
Regulatory T Cells in Systemic Sclerosis: a Comprehensive Review. Gleb Slobodin, Doron Rimar. Clin Rev Allergy Immunol, 2016 Jun 20; 52(2). PMID: 27318947 Review.
Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection. Steven Kho, Jutta Marfurt, +13 authors, Tonia Woodberry. less Malar J, 2016 Jun 23; 15. PMID: 27328659 Free PMC article.
Hypermethylation of FOXP3 Promoter and Premature Aging of the Immune System in Female Patients with Panic Disorder? Martina Prelog, Deborah Hilligardt, +9 authors, Katharina Domschke. less PLoS One, 2016 Jul 01; 11(6). PMID: 27362416 Free PMC article.
Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features. Marta Magatti, Elsa Vertua, +5 authors, Ornella Parolini. less J Tissue Eng Regen Med, 2016 Jul 12; 11(10). PMID: 27396853 Free PMC article.
Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut. Kazuhiko Kakihana, Yuki Fujioka, +16 authors, Kazuteru Ohashi. less Blood, 2016 Jul 28; 128(16). PMID: 27461930 Free PMC article. Highly Cited.
Affinity for self antigen selects Treg cells with distinct functional properties. Lena Wyss, Brian D Stadinski, +9 authors, Ed Palmer. less Nat Immunol, 2016 Aug 02; 17(9). PMID: 27478940 Free PMC article.
Altered Treg and cytokine responses in RSV-infected infants. Allison F Christiaansen, Muhammad A Syed, +4 authors, Steven M Varga. less Pediatr Res, 2016 Nov 02; 80(5). PMID: 27486703 Free PMC article.
Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting. Belal Chaudhary, Eyad Elkord. Vaccines (Basel), 2016 Aug 12; 4(3). PMID: 27509527 Free PMC article. Highly Cited. Review.
Regulatory T Cells: Central Concepts from Ontogeny to Therapy. Bernard Khor. Transfus Med Rev, 2016 Aug 16; 31(1). PMID: 27523957 Free PMC article. Review.
Distinctive Leukocyte Subpopulations According to Organ Type in Cynomolgus Macaques. Jonah S Zitsman, Paula Alonso-Guallart, +4 authors, Raimon Duran-Struuck. less Comp Med, 2016 Aug 20; 66(4). PMID: 27538862 Free PMC article.
Ex-vivo characterization of regulatory T cells in pulmonary tuberculosis patients, latently infected persons, and healthy endemic controls. Martha Zewdie, Rawleigh Howe, +7 authors, Markos Abebe. less Tuberculosis (Edinb), 2016 Aug 25; 100. PMID: 27553411 Free PMC article.
Data on correlations between T cell subset frequencies and length of partial remission in type 1 diabetes. Aditi Narsale, Rosita Moya, +2 authors, Joanna Davida Davies. less Data Brief, 2016 Sep 01; 8. PMID: 27579340 Free PMC article.
Regulatory CD4+ T-Cell Subsets and Anti-Citrullinated Protein Antibody Repertoire: Potential Biomarkers for Arthritis Development in Seropositive Arthralgia Patients? Koen M J Janssen, Johanna Westra, +5 authors, Elisabeth Brouwer. less PLoS One, 2016 Sep 02; 11(9). PMID: 27585422 Free PMC article.
Lymphocyte-mediated Immune Regulation in Health and Disease: The Treg and γδ T Cell Co-conspiracy. Kyle K Payne. Immunol Invest, 2016 Oct 25; 45(8). PMID: 27617588 Free PMC article. Review.
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer. Eleonora Timperi, Ilenia Pacella, +12 authors, Silvia Piconese. less Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622025 Free PMC article.
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis. Takayoshi Morita, Yoshihito Shima, +3 authors, Atsushi Kumanogoh. less PLoS One, 2016 Sep 14; 11(9). PMID: 27622457 Free PMC article. Systematic Review.
Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives. Hannah C Jeffery, Manjit Kaur Braitch, Solomon Brown, Ye Htun Oo. Front Immunol, 2016 Sep 23; 7. PMID: 27656181 Free PMC article. Review.
Restoring Regulatory T Cells in Type 1 Diabetes. Allyson Spence, Qizhi Tang. Curr Diab Rep, 2016 Sep 25; 16(11). PMID: 27664043 Review.
INTIMATE PARTNER VIOLENCE IS ASSOCIATED WITH INCREASED CD4+ T-CELL ACTIVATION AMONG HIV-NEGATIVE HIGH-RISK WOMEN. Ameeta S Kalokhe, Chris C Ibegbu, +4 authors, Rob Stephenson. less Pathog Immun, 2016 Sep 27; 1(1). PMID: 27668294 Free PMC article.
Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood. Laura F Su, Daniel Del Alcazar, +2 authors, Erietta Stelekati, E John Wherry, Mark M Davis. less Proc Natl Acad Sci U S A, 2016 Sep 30; 113(41). PMID: 27681619 Free PMC article.
FOXP3+ associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients. Jian-Guo Zhang, Xiao-Juan Chen, Tao Liu, Shu-Juan Jiang. Exp Ther Med, 2016 Oct 06; 12(4). PMID: 27703517 Free PMC article.
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Josalyn L Cho, Morris F Ling, +18 authors, Andrew D Luster. less Sci Transl Med, 2016 Oct 07; 8(359). PMID: 27708065 Free PMC article.
Pre-transplant donor CD4- invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease. M-T Rubio, M Bouillié, +13 authors, O Hermine. less Leukemia, 2016 Oct 16; 31(4). PMID: 27740636
A multistrain probiotic formulation attenuates skin symptoms of atopic dermatitis in a mouse model through the generation of CD4+Foxp3+ T cells. Joo-Hyun Shin, Myung-Jun Chung, Jae-Gu Seo. Food Nutr Res, 2016 Nov 03; 60. PMID: 27802847 Free PMC article.
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. Masahiro Hirakawa, Tiago R Matos, +16 authors, Jerome Ritz. less JCI Insight, 2016 Nov 05; 1(18). PMID: 27812545 Free PMC article.
Utilization of leukapheresis and CD4 positive selection in Treg isolation and the ex-vivo expansion for a clinical application in transplantation and autoimmune disorders. Karolina Gołąb, Randall Grose, +8 authors, Piotr Witkowski. less Oncotarget, 2016 Nov 09; 7(48). PMID: 27821811 Free PMC article.
Subset- and Antigen-Specific Effects of Treg on CD8+ T Cell Responses in Chronic HIV Infection. Maria Nikolova, Aurélie Wiedemann, +3 authors, Yves Lévy. less PLoS Pathog, 2016 Nov 10; 12(11). PMID: 27829019 Free PMC article.
Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment. Susana L Silva, Ana E Sousa. Front Pediatr, 2016 Nov 16; 4. PMID: 27843891 Free PMC article. Review.
Friend or foe? Mogamulizumab in allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia/lymphoma. Shigeo Fuji, Takero Shindo. Stem Cell Investig, 2016 Nov 22; 3. PMID: 27868052 Free PMC article. Review.
Foxp3, Regulatory T Cell, and Autoimmune Diseases. Jin-Hui Tao, Miao Cheng, +3 authors, Jiang-Ping Tang, Qin Liu, Fan Pan, Xiang-Pei Li. less Inflammation, 2016 Nov 25; 40(1). PMID: 27882473 Review.
Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus. Fabio D'Amico, Evangelia Skarmoutsou, +8 authors, Alon Keinan. less Immunol Lett, 2016 Nov 27; 181. PMID: 27888057 Free PMC article.
Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice. Ya-Hui Ma, Jie Zhang, +3 authors, Xue Chen, You-Fu Xie, Yan-Hua Pang, Xin-Juan Liu. less World J Gastroenterol, 2016 Nov 30; 22(42). PMID: 27895423 Free PMC article.
Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Feifei Qiu, Chun-Ling Liang, +5 authors, Zhenhua Dai. less Oncotarget, 2016 Dec 03; 8(1). PMID: 27902485 Free PMC article. Highly Cited. Review.
An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy. Chie Miyabe, Yoshishige Miyabe, +4 authors, Sebastian Unizony. less Ann Rheum Dis, 2016 Dec 09; 76(5). PMID: 27927642 Free PMC article.
Prognostic value of circulating regulatory T cell subsets in untreated non-small cell lung cancer patients. Athanasios Kotsakis, Filippos Koinis, +5 authors, Eleni-Kyriaki Vetsika. less Sci Rep, 2016 Dec 16; 6. PMID: 27976733 Free PMC article.
Regulatory T cells in cancer immunotherapy. Atsushi Tanaka, Shimon Sakaguchi. Cell Res, 2016 Dec 21; 27(1). PMID: 27995907 Free PMC article. Highly Cited. Review.
Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study. Emily Parsons, Juliana A Otieno, +5 authors, Ann M Moormann. less PLoS One, 2016 Dec 30; 11(12). PMID: 28033393 Free PMC article.
Regulatory T Cells in Hepatitis B and C Virus Infections. Min Kyung Jung, Eui-Cheol Shin. Immune Netw, 2016 Dec 31; 16(6). PMID: 28035208 Free PMC article. Review.
Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells. A K Marwaha, C Panagiotopoulos, +6 authors, R Tan. less Genes Immun, 2017 Jan 06; 18(1). PMID: 28053319 Free PMC article.
CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression. Rebeca Arroyo Hornero, Gareth J Betts, +3 authors, Kathryn J Wood. less Transplantation, 2017 Jan 25; 101(2). PMID: 28118317 Free PMC article.
Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies. Persephone Borrow, M Anthony Moody. Immunol Rev, 2017 Jan 31; 275(1). PMID: 28133804 Free PMC article. Review.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. Tie Zheng Hou, Nisha Verma, +17 authors, David M Sansom. less Blood, 2017 Feb 06; 129(11). PMID: 28159733 Free PMC article.
Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients. Kilian Wistuba-Hamprecht, Alexander Martens, +18 authors, Benjamin Weide. less Eur J Cancer, 2017 Feb 09; 73. PMID: 28167454 Free PMC article.
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma. Antonio Miguel, Luis Sendra, +5 authors, Salvador F Aliño. less Onco Targets Ther, 2017 Feb 09; 10. PMID: 28176947 Free PMC article.
Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells. Elodie Picarda, Séverine Bézie, +10 authors, Carole Guillonneau. less JCI Insight, 2017 Feb 15; 2(3). PMID: 28194440 Free PMC article.
Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus. Angelika Schmidt, Cosima C Rieger, +6 authors, Annegret Kuhn. less Immunol Res, 2017 Feb 23; 65(2). PMID: 28224362
Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study. Kornelis S M van der Geest, Qi Wang, +6 authors, Annemieke M H Boots. less Immun Ageing, 2017 Mar 03; 14. PMID: 28250797 Free PMC article.
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance. B Sprangers, S DeWolf, +18 authors, M Sykes. less Am J Transplant, 2017 Mar 03; 17(8). PMID: 28251801 Free PMC article.
Age-related changes in CD4+CD25+FOXP3+ regulatory T cells and their relationship with lung cancer. Pan-Fei Hou, Li-Jing Zhu, Xiao-Ying Chen, Zhu-Qiang Qiu. PLoS One, 2017 Mar 03; 12(3). PMID: 28253320 Free PMC article.
Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation. Yuan Kong, Yu-Tong Wang, +7 authors, Xiao-Jun Huang. less J Transl Med, 2017 Mar 16; 15(1). PMID: 28292332 Free PMC article.
The accumulation of regulatory T cells in the hepatic hilar lymph nodes in biliary atresia. Naoya Sakamoto, Toshihiro Muraji, Haruo Ohtani, Kouji Masumoto. Surg Today, 2017 Mar 16; 47(10). PMID: 28293742
Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway. Jie Wen, Ying Zhou, +9 authors, Wei Cai. less Cell Death Differ, 2017 Mar 18; 24(6). PMID: 28304404 Free PMC article.
Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation. Tonia Woodberry, Jessica R Loughland, +10 authors, Nicholas M Anstey. less Infect Immun, 2017 Mar 23; 85(6). PMID: 28320838 Free PMC article.
Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection. Milda Naciute, Gabriele Maciunaite, +5 authors, Irute Girkontaite. less In Vivo, 2017 Mar 31; 31(2). PMID: 28358698 Free PMC article.
Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment. Azharuddin Sajid Syed Khaja, Salman M Toor, +4 authors, Eyad Elkord. less Oncotarget, 2017 Apr 08; 8(20). PMID: 28388539 Free PMC article.
Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes. Luciele G Minuzzi, Luis Rama, +4 authors, Ana M Teixeira. less Eur J Appl Physiol, 2017 Apr 10; 117(6). PMID: 28391394
Regulatory T cells: tolerance induction in solid organ transplantation. T Vaikunthanathan, N Safinia, +2 authors, D Boardman, R I Lechler, G Lombardi. less Clin Exp Immunol, 2017 Apr 20; 189(2). PMID: 28422316 Free PMC article. Review.
Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Holger Meinicke, Anna Bremser, +7 authors, Ana Izcue. less Immunology, 2017 Apr 25; 152(1). PMID: 28437001 Free PMC article.
αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis. Christopher A Lamb, John C Mansfield, +13 authors, John A Kirby. less J Crohns Colitis, 2017 Apr 30; 11(5). PMID: 28453768 Free PMC article.
Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells. Nicholas A Zwang, Joseph R Leventhal. J Am Soc Nephrol, 2017 May 04; 28(7). PMID: 28465379 Free PMC article. Review.
IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154-CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice. Lerisa Govender, Jean-Christophe Wyss, +2 authors, Rajesh Kumar, Manuel Pascual, Dela Golshayan. less Front Immunol, 2017 May 10; 8. PMID: 28484450 Free PMC article.
Clinicopathologic and prognostic significance of regulatory T cells in patients with hepatocellular carcinoma: a meta-analysis. Lejia Sun, Gang Xu, +7 authors, Yilei Mao. less Oncotarget, 2017 May 11; 8(24). PMID: 28487498 Free PMC article.
Regulatory T Cells and Pro-inflammatory Responses Predominate in Children with Tuberculosis. Elizabeth Whittaker, Mark Nicol, Heather J Zar, Beate Kampmann. Front Immunol, 2017 May 11; 8. PMID: 28487695 Free PMC article.
The rise of IL-2 therapy - a picture beyond Treg cells. Zhanguo Li, Jing He, Di Yu. Nat Rev Rheumatol, 2017 May 12; 13(6). PMID: 28490785
Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks. Mohamed B Ezzelarab, Angus W Thomson. Curr Transplant Rep, 2017 May 23; 3(4). PMID: 28529840 Free PMC article.
Expansion of CD25-Negative Forkhead Box P3-Positive T Cells during HIV and Mycobacterium tuberculosis Infection. Matías T Angerami, Guadalupe V Suarez, +7 authors, María F Quiroga. less Front Immunol, 2017 May 26; 8. PMID: 28536578 Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses. Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee. less Oncotarget, 2017 May 26; 8(29). PMID: 28537894 Free PMC article.
Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives. N Costa, O Marques, +15 authors, C Fesel. less Clin Exp Immunol, 2017 May 26; 189(3). PMID: 28542701 Free PMC article.
High PD-1 expression on regulatory and effector T-cells in lung cancer draining lymph nodes. Rieneke van de Ven, Anna-Larissa N Niemeijer, +7 authors, Adrianus J de Langen. less ERJ Open Res, 2017 Jun 01; 3(2). PMID: 28560238 Free PMC article.
IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. Gavin Whitehouse, Elizabeth Gray, +11 authors, Marc Martinez-Llordella. less Proc Natl Acad Sci U S A, 2017 Jun 07; 114(27). PMID: 28584086 Free PMC article.
Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy. Dorien Feyaerts, Marilen Benner, +3 authors, Renate G van der Molen. less Sci Rep, 2017 Jun 08; 7(1). PMID: 28588205 Free PMC article.
Association of increased Treg and Th17 with pathogenesis of moyamoya disease. Leihua Weng, Xiang Cao, +12 authors, Yun Xu. less Sci Rep, 2017 Jun 10; 7(1). PMID: 28596558 Free PMC article.
Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer. Azharuddin Sajid Syed Khaja, Salman M Toor, +2 authors, Haytham El Salhat, Bassam R Ali, Eyad Elkord. less Front Immunol, 2017 Jun 13; 8. PMID: 28603527 Free PMC article.
T follicular regulatory cells in mice and men. Ana Raquel Maceiras, Valter R Fonseca, Ana Agua-Doce, Luis Graca. Immunology, 2017 Jun 16; 152(1). PMID: 28617936 Free PMC article. Review.
Counteracting dysfunction of regulatory T cells in organ transplantation. Cees van Kooten. Proc Natl Acad Sci U S A, 2017 Jun 24; 114(27). PMID: 28642347 Free PMC article.
Sexual Dimorphic Responses in Lymphocytes of Healthy Individuals after Carica papaya Consumption. Nur Ramziahrazanah Jumat, Mun Yee Chong, +3 authors, Maha Abdullah. less Front Immunol, 2017 Jun 27; 8. PMID: 28649252 Free PMC article.
Regulatory T cell frequencies and phenotypes following anti-viral vaccination. A Charlotte M T de Wolf, Susan van Aalst, +5 authors, Femke Broere. less PLoS One, 2017 Jun 29; 12(6). PMID: 28658271 Free PMC article.
Spectrum of T-lymphocyte activities regulating allergic lung inflammation. Erwin W Gelfand, Anthony Joetham, +2 authors, Meiqin Wang, Katsuyuki Takeda, Michaela Schedel. less Immunol Rev, 2017 Jun 29; 278(1). PMID: 28658551 Free PMC article. Review.
Memory T Cells in Type 1 Diabetes: the Devil is in the Detail. Aditi Narsale, Joanna D Davies. Curr Diab Rep, 2017 Jul 04; 17(8). PMID: 28670660 Review.
Significant augmentation of regulatory T cell numbers occurs during the early neonatal period. S Hayakawa, N Ohno, S Okada, M Kobayashi. Clin Exp Immunol, 2017 Jul 06; 190(2). PMID: 28677152 Free PMC article.
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. Susana L Silva, Adriana Albuquerque, +6 authors, Ana E Sousa. less PLoS One, 2017 Jul 08; 12(7). PMID: 28686710 Free PMC article.
Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis. Anderson P Jones, Stephanie Trend, +8 authors, Prue H Hart. less Clin Transl Immunology, 2017 Jul 12; 6(5). PMID: 28690849 Free PMC article.
A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers. James Badger Wing, Yohko Kitagawa, +11 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2017 Jul 13; 114(31). PMID: 28698369 Free PMC article. Highly Cited.
Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine. Vedran Brezar, Lylia Hani, +5 authors, Nabila Seddiki. less PLoS Pathog, 2017 Jul 15; 13(7). PMID: 28708863 Free PMC article.
The Plasticity and Stability of Regulatory T Cells during Viral-Induced Inflammatory Lesions. Siddheshvar Bhela, Siva Karthik Varanasi, +3 authors, Barry T Rouse. less J Immunol, 2017 Jul 16; 199(4). PMID: 28710254 Free PMC article.
An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment. Leena Halim, Marco Romano, +15 authors, Giovanna Lombardi. less Cell Rep, 2017 Jul 21; 20(3). PMID: 28723576 Free PMC article.
Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells. Enzo Candia, Paz Reyes, +6 authors, Juan Alberto Fierro. less PLoS One, 2017 Jul 27; 12(7). PMID: 28746369 Free PMC article.
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity. Ricardo C Ferreira, Henry Z Simons, +16 authors, Marcin L Pekalski. less J Autoimmun, 2017 Jul 28; 84. PMID: 28747257 Free PMC article.
Immunomodulation of RA Patients' PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens. Smadar Gertel, Gidi Karmon, +5 authors, Howard Amital. less Mediators Inflamm, 2017 Jul 29; 2017. PMID: 28751821 Free PMC article.
The regulation of immune tolerance by FOXP3. Ling Lu, Joseph Barbi, Fan Pan. Nat Rev Immunol, 2017 Aug 02; 17(11). PMID: 28757603 Free PMC article. Highly Cited. Review.
Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it? Caroline M Hull, Mark Peakman, Timothy I M Tree. Diabetologia, 2017 Aug 05; 60(10). PMID: 28770318 Free PMC article. Review.
Therapeutic immune monitoring of CD4+CD25+ T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Ziyuan Lu, Na Xu, +8 authors, Xiaoli Liu. less Oncol Lett, 2017 Aug 16; 14(2). PMID: 28808483 Free PMC article.
Increased tumor-infiltrating CD45RA-CCR7- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress. Fang-Yuan Mao, Hui Kong, +17 authors, Yuan Zhuang. less Cell Death Dis, 2017 Aug 18; 8(8). PMID: 28817117 Free PMC article.
The role of dietary sodium intake on the modulation of T helper 17 cells and regulatory T cells in patients with rheumatoid arthritis and systemic lupus erythematosus. Rossana Scrivo, Laura Massaro, +9 authors, Guido Valesini. less PLoS One, 2017 Sep 07; 12(9). PMID: 28877244 Free PMC article.
Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25- T Cell Subsets in Transplant Tolerance. Bruce M Hall, Catherine M Robinson, +6 authors, Suzanne J Hodgkinson. less Front Immunol, 2017 Sep 08; 8. PMID: 28878770 Free PMC article.
NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer. Yenkel Grinberg-Bleyer, Hyunju Oh, +7 authors, Sankar Ghosh. less Cell, 2017 Sep 09; 170(6). PMID: 28886380 Free PMC article. Highly Cited.
Increased activated regulatory T cells proportion correlate with the severity of idiopathic pulmonary fibrosis. Ziliang Hou, Qiao Ye, +3 authors, Meihua Qiu, Yu Hao, Junyan Han, Hui Zeng. less Respir Res, 2017 Sep 10; 18(1). PMID: 28886713 Free PMC article.
Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study. Francisco Salcido-Ochoa, Susan Swee-Shan Hue, +7 authors, Olaf Rotzschke. less Int J Nephrol, 2017 Sep 13; 2017. PMID: 28894608 Free PMC article.
A positive-feedback loop between tumour infiltrating activated Treg cells and type 2-skewed macrophages is essential for progression of laryngeal squamous cell carcinoma. Wei Sun, Fan-Qin Wei, +9 authors, Wei-Ping Wen. less Br J Cancer, 2017 Sep 28; 117(11). PMID: 28949956 Free PMC article.
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. Erin Janssen, Sudha Kumari, +9 authors, Raif S Geha. less JCI Insight, 2017 Oct 06; 2(19). PMID: 28978806 Free PMC article.
Regulatory T-cell heterogeneity and the cancer immune response. Kirsten A Ward-Hartstonge, Roslyn A Kemp. Clin Transl Immunology, 2017 Oct 07; 6(9). PMID: 28983402 Free PMC article. Review.
T-cell regulation in Erythema Nodosum Leprosum. Edessa Negera, Stephen L Walker, +4 authors, Diana N Lockwood. less PLoS Negl Trop Dis, 2017 Oct 11; 11(10). PMID: 28991896 Free PMC article.
Characterization of T-cell subpopulations in patients with chronic rhinosinusitis with nasal polyposis. Pascal Ickrath, Norbert Kleinsasser, +5 authors, Stephan Hackenberg. less Allergy Rhinol (Providence), 2017 Oct 27; 8(3). PMID: 29070271 Free PMC article.
Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy. Laura Passerini, Rosa Bacchetta. Front Immunol, 2017 Oct 28; 8. PMID: 29075264 Free PMC article. Review.
IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases. Min Kyung Jung, Jeong-Eun Kwak, Eui-Cheol Shin. Immune Netw, 2017 Nov 03; 17(5). PMID: 29093649 Free PMC article. Review.
Targeting the epitope spreader Pep19 by naïve human CD45RA+ regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy. Hyun-Joo Kim, Gil Sun Cha, +5 authors, Jeomil Choi. less J Periodontal Implant Sci, 2017 Nov 03; 47(5). PMID: 29093987 Free PMC article.
Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer. Sara Santagata, Maria Napolitano, +12 authors, Stefania Scala. less Oncotarget, 2017 Nov 05; 8(44). PMID: 29100374 Free PMC article.
The role of regulatory T cells in the regulation of upper airway inflammation. Charlie Palmer, Jennifer K Mulligan, Sarah E Smith, Carl Atkinson. Am J Rhinol Allergy, 2017 Nov 11; 31(6). PMID: 29122078 Free PMC article.
Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis. Marco Romano, Daria Sollazzo, +10 authors, Lucia Catani. less Oncoimmunology, 2017 Nov 11; 6(10). PMID: 29123956 Free PMC article.
Memory Regulatory T cells Increase Only In Inflammatory Phase of Chronic Hepatitis B Infection and Related to Galectin-9/Tim-3 interaction. Ching-Chih Hu, Wen-Juei Jeng, +8 authors, Chun-Yen Lin. less Sci Rep, 2017 Nov 12; 7(1). PMID: 29127350 Free PMC article.
Regulatory T-cells in acute dengue viral infection. Hemadri Eresha Jayaratne, Dulharie Wijeratne, +5 authors, Gathsaurie Neelika Malavige. less Immunology, 2017 Nov 16; 154(1). PMID: 29140541 Free PMC article.
Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes. Yu Wang, Ying-Jun Chang, +6 authors, Xiao-Jun Huang. less Oncoimmunology, 2017 Nov 18; 6(11). PMID: 29147612 Free PMC article.
Maternal-Fetal rejection reactions are unconstrained in preeclamptic women. Tina A Nguyen, Daniel A Kahn, Andrea I Loewendorf. PLoS One, 2017 Nov 28; 12(11). PMID: 29176779 Free PMC article.
Engineering Specificity and Function of Therapeutic Regulatory T Cells. Jenny L McGovern, Graham P Wright, Hans J Stauss. Front Immunol, 2017 Nov 28; 8. PMID: 29176976 Free PMC article. Review.
Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells. Makoto Miyara, Driss Chader, +9 authors, Guy Gorochov. less Oncotarget, 2016 Jul 28; 8(62). PMID: 29285209 Free PMC article.
Immune monitoring of transplant patients in transient mixed chimerism tolerance trials. Megan Sykes. Hum Immunol, 2018 Jan 01; 79(5). PMID: 29289741 Free PMC article. Review.
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis. Kimitoshi Kimura, Hirohiko Hohjoh, +7 authors, Takashi Yamamura. less Nat Commun, 2018 Jan 04; 9(1). PMID: 29295981 Free PMC article. Highly Cited.
Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression. Conor Donnelly, Brad Dykstra, +5 authors, Clare Baecher-Allan. less Sci Rep, 2018 Jan 13; 8(1). PMID: 29323143 Free PMC article.
Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype. Aditi Narsale, Rosita Moya, Joanna Davida Davies. Clin Immunol, 2018 Jan 14; 188. PMID: 29330114 Free PMC article.
Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy. Tom Erkers, Arwen Stikvoort, Michael Uhlin. Stem Cells Int, 2018 Jan 20; 2017. PMID: 29348758 Free PMC article. Review.
The Different Functional Distribution of "Not Effector" T Cells (Treg/Tnull) in Colorectal Cancer. Elena Niccolai, Federica Ricci, +10 authors, Amedeo Amedei. less Front Immunol, 2018 Jan 30; 8. PMID: 29375559 Free PMC article.
Suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis. Tetsuro Hanada, Shunichiro Tsuji, +6 authors, Takashi Murakami. less Reprod Biol Endocrinol, 2018 Feb 03; 16(1). PMID: 29391020 Free PMC article.
Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis. Pascal Ickrath, Norbert Kleinsasser, +5 authors, Stephan Hackenberg. less Clin Exp Otorhinolaryngol, 2018 Feb 08; 11(2). PMID: 29409312 Free PMC article.
Placental implantation over prior cesarean scar causes activation of fetal regulatory T cells. Tina A Nguyen, Daniel A Kahn, Andrea I Loewendorf. Immun Inflamm Dis, 2018 Feb 13; 6(2). PMID: 29430878 Free PMC article.
Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. David Zemmour, Rapolas Zilionis, +3 authors, Christophe Benoist. less Nat Immunol, 2018 Feb 13; 19(3). PMID: 29434354 Free PMC article. Highly Cited.
α1-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease. John M Magenau, Steven C Goldstein, +16 authors, Pavan Reddy. less Blood, 2018 Feb 14; 131(12). PMID: 29437593 Free PMC article.
Tregs in SLE: an Update. Antonio La Cava. Curr Rheumatol Rep, 2018 Feb 22; 20(2). PMID: 29464438 Review.
CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures. Anna Nowak, Dominik Lock, +9 authors, Alexander Scheffold. less Front Immunol, 2018 Feb 23; 9. PMID: 29467769 Free PMC article.
Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses. Christel Rothe Brinkmann, Jesper Falkesgaard Højen, +10 authors, Martin Tolstrup. less mSphere, 2018 Feb 23; 3(1). PMID: 29468194 Free PMC article.
Human FOXP3+ T regulatory cell heterogeneity. Audrey Mohr, Rajneesh Malhotra, +2 authors, Gaell Mayer, Guy Gorochov, Makoto Miyara. less Clin Transl Immunology, 2018 Feb 28; 7(1). PMID: 29484183 Free PMC article. Highly Cited. Review.
FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis. Manolo Sambucci, Francesca Gargano, +9 authors, Giovanna Borsellino. less Sci Rep, 2018 Mar 01; 8(1). PMID: 29487369 Free PMC article.
Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies. Richard Duggleby, Robert David Danby, J Alejandro Madrigal, Aurore Saudemont. Front Immunol, 2018 Mar 01; 9. PMID: 29487602 Free PMC article. Review.
Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside. Wook-Jin Chae, Alfred L M Bothwell. Front Immunol, 2018 Mar 06; 9. PMID: 29503652 Free PMC article. Review.
FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity. Theresa L Whiteside. Expert Opin Ther Targets, 2018 Mar 14; 22(4). PMID: 29532697 Free PMC article. Review.
Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles. Mei Zhang, Julian A Kim, Alex Yee-Chen Huang. Front Immunol, 2018 Mar 15; 9. PMID: 29535722 Free PMC article. Review.
Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells. Niloufar Safinia, Nathali Grageda, +5 authors, Giovanna Lombardi. less Front Immunol, 2018 Mar 15; 9. PMID: 29535728 Free PMC article. Review.
Enhanced expression of PD-1 and other activation markers by CD4+ T cells of young but not old patients with metastatic melanoma. Rob R H van den Brom, Kornelis S M van der Geest, +2 authors, Elisabeth Brouwer, Geke A P Hospers, Annemieke M H Boots. less Cancer Immunol Immunother, 2018 Mar 17; 67(6). PMID: 29546435 Free PMC article.
Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder. Pierre Ellul, Encarnita Mariotti-Ferrandiz, Marion Leboyer, David Klatzmann. Front Neurol, 2018 Apr 05; 9. PMID: 29615964 Free PMC article.
Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis. Hannah C Jeffery, Manjit K Braitch, +14 authors, Ye H Oo. less Hepatol Commun, 2018 Apr 06; 2(4). PMID: 29619420 Free PMC article.
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction. Manja Idorn, Maria Olsen, +6 authors, Per Thor Straten. less Oncoimmunology, 2018 Apr 11; 7(4). PMID: 29632724 Free PMC article.
Immunological memories of the bone marrow. Hyun-Dong Chang, Koji Tokoyoda, Andreas Radbruch. Immunol Rev, 2018 Apr 18; 283(1). PMID: 29664564 Free PMC article. Review.
Pathological conversion of regulatory T cells is associated with loss of allotolerance. Jing Hua, Takenori Inomata, +5 authors, Reza Dana. less Sci Rep, 2018 May 08; 8(1). PMID: 29728574 Free PMC article. Highly Cited.
Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus. Masayuki Mizui, George C Tsokos. Front Immunol, 2018 May 15; 9. PMID: 29755456 Free PMC article. Review.
Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype. James D Lord, S Alice Long, +5 authors, Jane H Buckner. less Clin Immunol, 2018 May 31; 193. PMID: 29842945 Free PMC article.
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. Nicole M Chapman, Hu Zeng, +7 authors, Hongbo Chi. less Nat Commun, 2018 May 31; 9(1). PMID: 29844370 Free PMC article. Highly Cited.
Emerging Functions of Regulatory T Cells in Tissue Homeostasis. Amit Sharma, Dipayan Rudra. Front Immunol, 2018 Jun 12; 9. PMID: 29887862 Free PMC article. Highly Cited. Review.
Immune Privilege and Eye-Derived T-Regulatory Cells. Hiroshi Keino, Shintaro Horie, Sunao Sugita. J Immunol Res, 2018 Jun 12; 2018. PMID: 29888291 Free PMC article. Review.
Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3+CD4+ T Cells. Ryutaro Iwabuchi, Shota Ikeno, +4 authors, Kazutaka Terahara. less Front Immunol, 2018 Jun 13; 9. PMID: 29892279 Free PMC article.
Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation. Julie Jacobs, Vanessa Deschoolmeester, +11 authors, Patrick Pauwels. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900042 Free PMC article.
Immunemodulatory Effects of 5-Azacitidin Through Expansion of Functional Regulatory T Cells on Paraneoplastic Inflammation Associated With Myelodysplastic Syndromes: A Case Report. Kentaro Serizawa, Hirokazu Tanaka, +3 authors, Itaru Matsumura. less Front Oncol, 2018 Jun 21; 8. PMID: 29922595 Free PMC article.
Roles of Myeloid and Lymphoid Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Ling Ni, Chen Dong. Front Immunol, 2018 Jul 07; 9. PMID: 29977245 Free PMC article. Review.
Regulation of the Immune Response by the Inflammatory Metabolic Microenvironment in the Context of Allotransplantation. Nicolas Degauque, Carole Brosseau, Sophie Brouard. Front Immunol, 2018 Jul 11; 9. PMID: 29988548 Free PMC article. Review.
A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme. David Bending, Alina Paduraru, +3 authors, Masahiro Ono. less EMBO J, 2018 Jul 12; 37(16). PMID: 29991564 Free PMC article.
Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells. Matthieu Sawaf, Jean-Daniel Fauny, +4 authors, Fanny Monneaux. less JCI Insight, 2018 Jul 13; 3(13). PMID: 29997289 Free PMC article.
Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. Natasa Kustrimovic, Cristoforo Comi, +12 authors, Marco Cosentino. less J Neuroinflammation, 2018 Jul 14; 15(1). PMID: 30001736 Free PMC article. Highly Cited.
CD4+CD45RA-FOXP3low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients. Helena L Silva-Neta, Maria C A Brelaz-de-Castro, +10 authors, Maira G R Pitta. less Biomed Res Int, 2018 Jul 17; 2018. PMID: 30009168 Free PMC article.
Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells. Daiju Sakurai, Ryosuke Uchida, +6 authors, Yoshitaka Okamoto. less BMC Res Notes, 2018 Jul 18; 11(1). PMID: 30012191 Free PMC article.
Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. D Calzada, S Baos, L Cremades-Jimeno, B Cárdaba. J Immunol Res, 2018 Jul 18; 2018. PMID: 30013991 Free PMC article. Review.
CD226 opposes TIGIT to disrupt Tregs in melanoma. Julien Fourcade, Zhaojun Sun, +11 authors, Hassane M Zarour. less JCI Insight, 2018 Jul 27; 3(14). PMID: 30046006 Free PMC article.
Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome. Stephanie Trend, Anderson P Jones, +10 authors, Prue H Hart. less Front Immunol, 2018 Jul 31; 9. PMID: 30057580 Free PMC article.
Elucidating T Cell Activation-Dependent Mechanisms for Bifurcation of Regulatory and Effector T Cell Differentiation by Multidimensional and Single-Cell Analysis. Alla Bradley, Tetsuo Hashimoto, Masahiro Ono. Front Immunol, 2018 Aug 01; 9. PMID: 30061879 Free PMC article.
Prognostic impact of the tumor immune microenvironment in synovial sarcoma. Naoki Oike, Hiroyuki Kawashima, +7 authors, Naoto Endo. less Cancer Sci, 2018 Aug 23; 109(10). PMID: 30133055 Free PMC article.
Regulatory T cells and asthma. Sheng-Tao Zhao, Chang-Zheng Wang. J Zhejiang Univ Sci B, 2018 Sep 05; 19(9). PMID: 30178633 Free PMC article. Review.
Increased circulating regulatory T cells in medicated people with schizophrenia. Deanna L Kelly, Xin Li, +5 authors, Leonardo H Tonelli. less Psychiatry Res, 2018 Sep 10; 269. PMID: 30195746 Free PMC article.
Control of Germinal Center Responses by T-Follicular Regulatory Cells. James B Wing, Murat Tekgüç, Shimon Sakaguchi. Front Immunol, 2018 Sep 11; 9. PMID: 30197643 Free PMC article. Review.
Clonally Expanded Decidual Effector Regulatory T Cells Increase in Late Gestation of Normal Pregnancy, but Not in Preeclampsia, in Humans. Sayaka Tsuda, Xiaoxin Zhang, +6 authors, Shigeru Saito. less Front Immunol, 2018 Sep 11; 9. PMID: 30197648 Free PMC article.
Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Hiroyuki Yoshitomi, Shio Kobayashi, +9 authors, Junya Toguchida. less Nat Commun, 2018 Sep 21; 9(1). PMID: 30232328 Free PMC article.
High CCR4 expression in the tumor microenvironment is a poor prognostic indicator in lung adenocarcinoma. Takahiro Karasaki, Guangliang Qiang, +11 authors, Jun Nakajima. less J Thorac Dis, 2018 Sep 21; 10(8). PMID: 30233846 Free PMC article.
Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer. Gemma A Foulds, Jayakumar Vadakekolathu, +9 authors, Stephanie E B McArdle. less Front Immunol, 2018 Sep 27; 9. PMID: 30254632 Free PMC article.
Regulatory T cells in the treatment of disease. Amir Sharabi, Maria G Tsokos, +3 authors, George C Tsokos. less Nat Rev Drug Discov, 2018 Oct 13; 17(11). PMID: 30310234 Highly Cited. Review.
Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment. Yasuko Tada, Yosuke Togashi, +7 authors, Kohei Shitara. less J Immunother Cancer, 2018 Oct 14; 6(1). PMID: 30314524 Free PMC article.
Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells. Yixiang Han, Yuqing Dong, +5 authors, Shenghui Zhang. less Front Immunol, 2018 Oct 16; 9. PMID: 30319662 Free PMC article.
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Tomokazu Sumida, Matthew R Lincoln, +7 authors, David A Hafler. less Nat Immunol, 2018 Oct 31; 19(12). PMID: 30374130 Free PMC article.
Regulatory T Cells in Systemic Sclerosis. Camelia Frantz, Cedric Auffray, Jerome Avouac, Yannick Allanore. Front Immunol, 2018 Oct 31; 9. PMID: 30374354 Free PMC article. Review.
Inhibitory Receptors and Pathways of Lymphocytes: The Role of PD-1 in Treg Development and Their Involvement in Autoimmunity Onset and Cancer Progression. Elena Gianchecchi, Alessandra Fierabracci. Front Immunol, 2018 Nov 06; 9. PMID: 30386337 Free PMC article. Highly Cited. Review.
Regulatory B and T lymphocytes in multiple sclerosis: friends or foes? Georgios K Vasileiadis, Efthymios Dardiotis, +5 authors, Georgios M Hadjigeorgiou. less Auto Immun Highlights, 2018 Nov 12; 9(1). PMID: 30415321 Free PMC article. Review.
Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation. Ekaterina Minskaia, Barbara C Saraiva, +5 authors, João F Lacerda. less Front Immunol, 2018 Nov 21; 9. PMID: 30455694 Free PMC article.
Increased activated regulatory T cell subsets and aging Treg-like cells in multiple myeloma and monoclonal gammopathy of undetermined significance: a case control study. Ji-Nuo Wang, Xin-Xin Cao, +3 authors, Ai-Lin Zhao, Hao Cai, Xuan Wang, Jian Li. less Cancer Cell Int, 2018 Nov 28; 18. PMID: 30479566 Free PMC article.
Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy. Lisanne Noordam, Margaretha E H Kaijen, +7 authors, Heleen Vroman. less Oncoimmunology, 2018 Dec 14; 7(12). PMID: 30524884 Free PMC article.
Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis. Mythilypriya Rajendran, Stephen Looney, +7 authors, Christopher W Cutler. less J Immunol, 2019 Apr 05; 202(9). PMID: 30944162 Free PMC article.
Differences in immune contextures among different molecular subtypes of gastric cancer and their prognostic impact. Joo Yeon Kim, Woo Gyeong Kim, Chae Hwa Kwon, Do Youn Park. Gastric Cancer, 2019 Jun 04; 22(6). PMID: 31152268
Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer. Taichi Kuwahara, Shoichi Hazama, +18 authors, Hiroaki Nagano. less Br J Cancer, 2019 Sep 07; 121(8). PMID: 31488881 Free PMC article.
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis. Hang Li, Tong Lu, +7 authors, Weiping Wen. less Front Immunol, 2019 Oct 17; 10. PMID: 31616436 Free PMC article.
Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation. Hester J Scheffer, Anita G M Stam, +7 authors, Tanja D de Gruijl. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646081 Free PMC article.
Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. Ioannis Kaffes, Frank Szulzewsky, +19 authors, Dolores Hambardzumyan. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646100 Free PMC article.
Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity. Paula Araya, Katherine A Waugh, +12 authors, Joaquín M Espinosa. less Proc Natl Acad Sci U S A, 2019 Nov 09; 116(48). PMID: 31699819 Free PMC article.
Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved. Diana D Álvarez-Luquín, Asiel Arce-Sillas, +10 authors, Laura Adalid-Peralta. less J Neuroinflammation, 2019 Nov 13; 16(1). PMID: 31711508 Free PMC article.
Helios, CD73 and CD39 Induction in Regulatory T Cells Exposed to Adipose Derived Mesenchymal Stem Cells. Maryam Fakhimi, Abdol Rasoul Talei, +2 authors, Abbas Ghaderi, Mojtaba Habibagahi, Mahboobeh Razmkhah. less Cell J, 2019 Nov 14; 22(2). PMID: 31721539 Free PMC article.
The Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis: A Meta-Analysis. Na-Lin Lai, Sheng-Xiao Zhang, +4 authors, Xiao-Feng Li. less J Immunol Res, 2019 Nov 28; 2019. PMID: 31772947 Free PMC article. Review.
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression. Ricardo C Ferreira, Xaquin Castro Dopico, +15 authors, John A Todd. less Front Immunol, 2019 Nov 30; 10. PMID: 31781109 Free PMC article.
OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling. Prabhakaran Kumar, Swarali Surendra Lele, +4 authors, Bellur S Prabhakar. less J Immunol, 2019 Nov 11; 203(12). PMID: 31704879 Free PMC article.
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Ju-Ha Kim, Jisung Hwang, +3 authors, Sung-Hoon Kim. less Mol Cancer, 2019 Dec 10; 18(1). PMID: 31815635 Free PMC article. Review.
Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation. Otavio Cabral-Marques, Lena F Schimke, +6 authors, Antonio Condino-Neto. less Front Immunol, 2019 Dec 19; 10. PMID: 31849949 Free PMC article. Review.
T Regulatory Cell Subpopulations Associated with Recent Ultraviolet Radiation Exposure in a Skin Cancer Screening Cohort. Rebecca S Hesterberg, Rossybelle P Amorrortu, +8 authors, Dana E Rollison. less J Immunol, 2018 Nov 06; 201(11). PMID: 30389774 Free PMC article.
Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro. Manuel A Podestà, Christian Binder, +8 authors, Megan Sykes. less Am J Transplant, 2019 Jul 19; 20(1). PMID: 31319439 Free PMC article.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells. Kazushige Yoshida, Masanori Okamoto, +13 authors, Naoto Saito. less BMC Cancer, 2020 Jan 10; 20(1). PMID: 31914969 Free PMC article.
CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation. Antonella Mancusi, Sara Piccinelli, Andrea Velardi, Antonio Pierini. Front Immunol, 2020 Jan 11; 10. PMID: 31921162 Free PMC article. Review.
Human labour is associated with altered regulatory T cell function and maternal immune activation. N M Shah, L F Edey, N Imami, M R Johnson. Clin Exp Immunol, 2019 Oct 17; 199(2). PMID: 31617583 Free PMC article.
One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity. Manolo Sambucci, Francesca Gargano, +2 authors, Gisella Guerrera, Luca Battistini, Giovanna Borsellino. less Front Immunol, 2020 Jan 21; 10. PMID: 31956323 Free PMC article. Review.
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. Margaret M Lowe, Ian Boothby, +21 authors, Michael D Rosenblum. less JCI Insight, 2019 Dec 20; 4(24). PMID: 31852848 Free PMC article.
Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells. Xiaoxu Ge, Yamei Zhao, +2 authors, Chao Chen, Jian Wang, Lifeng Sun. less Onco Targets Ther, 2020 Jan 31; 12. PMID: 31997881 Free PMC article. Review.
TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression. Paulo C M Urbano, Xuehui He, +5 authors, Hans J P M Koenen. less Front Immunol, 2020 Feb 11; 10. PMID: 32038615 Free PMC article.
Phenotypic and Transcriptomic Lymphocytes Changes in Allograft Recipients After Intravenous Immunoglobulin Therapy in Kidney Transplant Recipients. Caroline Pilon, Jeremy Bigot, +5 authors, Marie Matignon. less Front Immunol, 2020 Feb 11; 11. PMID: 32038663 Free PMC article.
Treatment effects of fingolimod in multiple sclerosis: Selective changes in peripheral blood lymphocyte subsets. Maria Hjorth, Nicolae Dandu, Johan Mellergård. PLoS One, 2020 Feb 06; 15(2). PMID: 32012202 Free PMC article.
Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment. Kyung Hwan Kim, Joon Young Hur, +9 authors, Eui-Cheol Shin. less Oncoimmunology, 2020 Feb 23; 9(1). PMID: 32076579 Free PMC article.
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. Mytrang H Do, Xinxin Wang, +7 authors, Ming O Li. less J Exp Med, 2019 Oct 28; 217(1). PMID: 31649036 Free PMC article.
Regulatory T cells in solid organ transplantation. Muhammad Atif, Filomena Conti, +2 authors, Guy Gorochov, Ye Htun Oo, Makoto Miyara. less Clin Transl Immunology, 2020 Feb 28; 9(2). PMID: 32104579 Free PMC article. Review.
Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells. Atsushi Tanaka, Hiroyoshi Nishikawa, +19 authors, Shimon Sakaguchi. less J Exp Med, 2019 Nov 11; 217(2). PMID: 31704808 Free PMC article.
Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation. Alessandra Colamatteo, Fortunata Carbone, +6 authors, Veronica De Rosa. less Front Immunol, 2020 Mar 03; 10. PMID: 32117202 Free PMC article. Review.
The Imbalance of Circulating Follicular Helper T Cells and Follicular Regulatory T Cells Is Associated With Disease Activity in Patients With Ulcerative Colitis. Yan Long, Changsheng Xia, +5 authors, Chen Liu. less Front Immunol, 2020 Mar 03; 11. PMID: 32117258 Free PMC article.
Impact of Radiochemotherapy on Immune Cell Subtypes in High-Grade Glioma Patients. Valérie Dutoit, Géraldine Philippin, +5 authors, Pierre-Yves Dietrich. less Front Oncol, 2020 Mar 03; 10. PMID: 32117743 Free PMC article.
Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells. Prabhakaran Kumar, Shikha Saini, +2 authors, Saad Khan, Swarali Surendra Lele, Bellur S Prabhakar. less Cell Immunol, 2018 Nov 30; 339. PMID: 30482489 Free PMC article. Review.
Characterization, biology, and expansion of regulatory T cells in the Cynomolgus macaque for preclinical studies. Paula Alonso-Guallart, Jonah S Zitsman, +8 authors, Raimon Duran-Struuck. less Am J Transplant, 2019 Feb 16; 19(8). PMID: 30768842 Free PMC article.
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Takahiro Kamada, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa. less Proc Natl Acad Sci U S A, 2019 Apr 28; 116(20). PMID: 31028147 Free PMC article. Highly Cited.
Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome. Stephanie Trend, Anderson P Jones, +11 authors, Prue H Hart. less Sci Rep, 2019 May 30; 9(1). PMID: 31138860 Free PMC article.
Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients. Tom D Y Reijnders, Coen A Stegeman, +3 authors, Wayel H Abdulahad. less Sci Rep, 2019 Jun 06; 9(1). PMID: 31164680 Free PMC article.
The Characterization of Regulatory T-Cell Profiles in Alzheimer's Disease and Multiple Sclerosis. Fausta Ciccocioppo, Paola Lanuti, +10 authors, Marco Marchisio. less Sci Rep, 2019 Jun 21; 9(1). PMID: 31217537 Free PMC article.
Low-molecular-weight-heparin increases Th1- and Th17-associated chemokine levels during pregnancy in women with unexplained recurrent pregnancy loss: a randomised controlled trial. E Rasmark Roepke, V Bruno, +8 authors, J Ernerudh. less Sci Rep, 2019 Aug 25; 9(1). PMID: 31444404 Free PMC article.
Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells. Angelika Schmidt, Johanna E Huber, +6 authors, Dirk Baumjohann. less EBioMedicine, 2020 Mar 03; 53. PMID: 32114393 Free PMC article.
A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following Hypomethylating Agent Failure. Amer M Zeidan, Hanna A Knaus, +17 authors, B Douglas Smith. less Clin Cancer Res, 2018 May 03; 24(15). PMID: 29716921 Free PMC article.
YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity. Xuhao Ni, Jinhui Tao, +17 authors, Fan Pan. less Cancer Discov, 2018 Jun 17; 8(8). PMID: 29907586 Free PMC article. Highly Cited.
CAR T cells for infection, autoimmunity and allotransplantation. Colby R Maldini, Gavin I Ellis, James L Riley. Nat Rev Immunol, 2018 Jul 27; 18(10). PMID: 30046149 Free PMC article. Highly Cited. Review.
Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus. Maria Dall'Era, Mariela L Pauli, +14 authors, Autoimmunity Centers of Excellence. less Arthritis Rheumatol, 2018 Oct 03; 71(3). PMID: 30277008 Free PMC article.
Relationship of post-transplant thymopoiesis with CD4+FoxP3+ regulatory T cell recovery associated with freedom from chronic graft versus host disease. Erin M Trovillion, Nicholas J Gloude, Eric J Anderson, Gerald P Morris. Bone Marrow Transplant, 2018 Nov 11; 54(6). PMID: 30413809 Free PMC article.
Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis. Verena Moosbrugger-Martinz, Robert Gruber, +4 authors, Sandrine Dubrac. less J Cell Mol Med, 2018 Dec 06; 23(2). PMID: 30515983 Free PMC article.
OMIP-053: Identification, Classification, and Isolation of Major FoxP3 Expressing Human CD4+ Treg Subsets. Johannes Nowatzky, Cristy Stagnar, Olivier Manches. Cytometry A, 2018 Dec 26; 95(3). PMID: 30584695 Free PMC article.
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody. Danbee Ha, Atsushi Tanaka, +10 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2018 Dec 28; 116(2). PMID: 30587582 Free PMC article.
Dendritic cells, T cells and their interaction in rheumatoid arthritis. P Wehr, H Purvis, S-C Law, R Thomas. Clin Exp Immunol, 2018 Dec 28; 196(1). PMID: 30589082 Free PMC article. Review.
FoxP3+ CXCR5+ CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome. M Ivanchenko, L A Aqrawi, +2 authors, A Björk, M Wahren-Herlenius, K Chemin. less Clin Exp Immunol, 2019 Jan 12; 195(3). PMID: 30632148 Free PMC article.
Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. Simon Glatigny, Barbara Höllbacher, +13 authors, Estelle Bettelli. less J Immunol, 2019 Jan 27; 202(5). PMID: 30683697 Free PMC article.
GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma. Adriaan A van Beek, Guoying Zhou, +14 authors, Jaap Kwekkeboom. less Int J Cancer, 2019 Feb 06; 145(4). PMID: 30719701 Free PMC article.
FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children. Tyyne Viisanen, Ahmad M Gazali, +7 authors, Tuure Kinnunen. less Front Immunol, 2019 Feb 07; 10. PMID: 30723474 Free PMC article.
Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels. A M Heeren, J Rotman, +9 authors, T D de Gruijl. less J Immunother Cancer, 2019 Feb 14; 7(1). PMID: 30755279 Free PMC article.
Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity. Marco Romano, Giorgia Fanelli, +2 authors, Caraugh Jane Albany, Giulio Giganti, Giovanna Lombardi. less Front Immunol, 2019 Feb 26; 10. PMID: 30804926 Free PMC article. Highly Cited. Review.
Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children. Julia Roider, Abigail Ngoepe, +6 authors, Alasdair Leslie. less Front Immunol, 2019 Feb 28; 10. PMID: 30809229 Free PMC article.
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses. Choong-Gu Lee, Ho-Keun Kwon, +10 authors, Sin-Hyeog Im. less JCI Insight, 2019 Mar 08; 4(5). PMID: 30843878 Free PMC article.
Treg cells in autoimmunity: from identification to Treg-based therapies. Lisa Göschl, Clemens Scheinecker, Michael Bonelli. Semin Immunopathol, 2019 Apr 07; 41(3). PMID: 30953162 Review.
Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity. Hiroshi Yano, Lawrence P Andrews, Creg J Workman, Dario A A Vignali. Immunology, 2019 May 16; 157(3). PMID: 31087644 Free PMC article. Highly Cited. Review.
Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges. Kei Kunimasa, Taichiro Goto. Int J Mol Sci, 2020 Jan 23; 21(2). PMID: 31963413 Free PMC article. Review.
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. Gertrude J Nieuwenhuijs-Moeke, Søren E Pischke, +5 authors, Henri G D Leuvenink. less J Clin Med, 2020 Jan 23; 9(1). PMID: 31963521 Free PMC article. Review.
The Impact of Dietary Components on Regulatory T Cells and Disease. Rebeca Arroyo Hornero, Ibrahim Hamad, Beatriz Côrte-Real, Markus Kleinewietfeld. Front Immunol, 2020 Mar 11; 11. PMID: 32153577 Free PMC article. Review.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy. Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee. Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592 Free PMC article. Review.
Peripheral blood immune cell-based biomarkers in anti-PD-1/PD-L1 therapy. Kyung Hwan Kim, Chang Gon Kim, Eui-Cheol Shin. Immune Netw, 2020 Mar 12; 20(1). PMID: 32158596 Free PMC article. Review.
From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics. D Bending, M Ono. Clin Exp Immunol, 2018 Aug 05; 197(1). PMID: 30076771 Free PMC article. Review.
The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases. A Mohr, M Atif, +2 authors, R Balderas, G Gorochov, M Miyara. less Clin Exp Immunol, 2019 Mar 05; 197(1). PMID: 30830965 Free PMC article. Review.
Mechanisms of human FoxP3+ Treg cell development and function in health and disease. M Attias, T Al-Aubodah, C A Piccirillo. Clin Exp Immunol, 2019 Mar 14; 197(1). PMID: 30864147 Free PMC article. Review.
Molecular and Phenotypic Characterization of Nine Patients with STAT1 GOF Mutations in China. Xuemei Chen, Qiling Xu, +15 authors, Xiaodong Zhao. less J Clin Immunol, 2019 Nov 07; 40(1). PMID: 31686315
Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal-Maternal Interface. Valentina Bruno, Giacomo Corrado, +8 authors, Enrico Vizza. less Front Oncol, 2020 Apr 01; 10. PMID: 32226771 Free PMC article. Review.
Effects of transarterial chemoembolization on regulatory T cell and its subpopulations in patients with hepatocellular carcinoma. Hana Park, Jae Hyung Jung, +6 authors, Kwang-Hyub Han. less Hepatol Int, 2020 Feb 20; 14(2). PMID: 32072464
Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis. Karine Chemin, Christina Gerstner, Vivianne Malmström. Front Immunol, 2019 Mar 28; 10. PMID: 30915067 Free PMC article. Review.
New Paradigm in the Role of Regulatory T Cells During Pregnancy. Sayaka Tsuda, Akitoshi Nakashima, Tomoko Shima, Shigeru Saito. Front Immunol, 2019 Apr 12; 10. PMID: 30972068 Free PMC article. Review.
T-Cell Compartmentalization and Functional Adaptation in Autoimmune Inflammation: Lessons From Pediatric Rheumatic Diseases. Gerdien Mijnheer, Femke van Wijk. Front Immunol, 2019 May 31; 10. PMID: 31143175 Free PMC article. Review.
Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response. Noymar Luque-Campos, Rafael A Contreras-López, +7 authors, Patricia Luz-Crawford. less Front Immunol, 2019 May 02; 10. PMID: 31040848 Free PMC article. Review.
Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges. Ilenia Pacella, Silvia Piconese. Front Immunol, 2019 Sep 12; 10. PMID: 31507585 Free PMC article. Review.
Cancer-driven changes link T cell frequency to muscle strength in people with cancer: a pilot study. Aditi Narsale, Rosa Moya, +4 authors, Joanna D Davies. less J Cachexia Sarcopenia Muscle, 2019 Apr 13; 10(4). PMID: 30977974 Free PMC article.
Mass Cytometry Discovers Two Discrete Subsets of CD39-Treg Which Discriminate MGUS From Multiple Myeloma. Felix Marsh-Wakefield, Annabel Kruzins, +14 authors, Slavica Vuckovic. less Front Immunol, 2019 Aug 21; 10. PMID: 31428081 Free PMC article.
Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells. Amara Seng, Kelsey L Krausz, +4 authors, Mary A Markiewicz. less Blood Adv, 2020 Apr 08; 4(7). PMID: 32259202 Free PMC article.
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? Yoshihiro Ohue, Hiroyoshi Nishikawa. Cancer Sci, 2019 May 19; 110(7). PMID: 31102428 Free PMC article. Highly Cited. Review.
Dawn of Monitoring Regulatory T Cells in (Pre-)clinical Studies: Their Relevance Is Slowly Recognised. A Charlotte M T de Wolf, Carla A Herberts, Marcel H N Hoefnagel. Front Med (Lausanne), 2020 Apr 18; 7. PMID: 32300597 Free PMC article. Systematic Review.
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells. Khalid Bin Dhuban, Sabrina Bartolucci, Eva d'Hennezel, Ciriaco A Piccirillo. Front Immunol, 2019 Aug 06; 10. PMID: 31379810 Free PMC article.
Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA. Rebeca Hid Cadena, Rosanne D Reitsema, +6 authors, Elisabeth Brouwer. less Front Immunol, 2019 Aug 06; 10. PMID: 31379838 Free PMC article.
Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes. Masahiro Ono. Immunology, 2020 Feb 06; 160(1). PMID: 32022254 Free PMC article. Review.
Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells. Claire Manuszak, Martha Brainard, +2 authors, Emily Thrash, F Stephen Hodi, Mariano Severgnini. less J Biol Methods, 2020 Apr 22; 7(2). PMID: 32313815 Free PMC article.
A unique thymus-derived regulatory T cell subset associated with systemic lupus erythematosus. Hironari Hanaoka, Tetsuya Nishimoto, +2 authors, Yuka Okazaki, Tsutomu Takeuchi, Masataka Kuwana. less Arthritis Res Ther, 2020 Apr 23; 22(1). PMID: 32317002 Free PMC article.
Tissue Infiltrating LTi-Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis. Audrey Mohr, Christophe Trésallet, +14 authors, Makoto Miyara. less Front Immunol, 2020 Apr 25; 11. PMID: 32328068 Free PMC article.
IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer. Scott N Furlan, Karnail Singh, +7 authors, Leslie S Kean. less Blood Adv, 2020 Apr 21; 4(8). PMID: 32311015 Free PMC article.
Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood. Keshav Motwani, Leeana D Peters, +11 authors, Todd M Brusko. less Front Immunol, 2020 May 01; 11. PMID: 32351504 Free PMC article.
High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer. Minyu Wang, Yu-Kuan Huang, +14 authors, Alex Boussioutas. less Clin Transl Immunology, 2020 May 08; 9(5). PMID: 32377339 Free PMC article.
Reparative T lymphocytes in organ injury. Franco R D'Alessio, Johanna T Kurzhagen, Hamid Rabb. J Clin Invest, 2019 Jul 02; 129(7). PMID: 31259743 Free PMC article. Review.
Regulatory T Cells: the Many Faces of Foxp3. Peter Georgiev, Louis-Marie Charbonnier, Talal A Chatila. J Clin Immunol, 2019 Sep 04; 39(7). PMID: 31478130 Free PMC article. Review.
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance. Neema Negi, Matthew D Griffin. Stem Cells, 2020 Jan 30; 38(5). PMID: 31995249 Free PMC article.
Transient Expression of IL-17A in Foxp3 Fate-Tracked Cells in Porphyromonas gingivalis-Mediated Oral Dysbiosis. Peter D Bittner-Eddy, Lori A Fischer, Massimo Costalonga. Front Immunol, 2020 May 12; 11. PMID: 32391008 Free PMC article.
Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells. Christin Riegel, Tina J Boeld, +3 authors, Matthias Edinger. less Leukemia, 2019 Nov 14; 34(3). PMID: 31719679 Free PMC article.
OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody. Hirofumi Ohmura, Kyoko Yamaguchi, +15 authors, Eishi Baba. less Br J Cancer, 2020 Mar 24; 122(10). PMID: 32203221 Free PMC article.
Role of Regulatory T Cells in Disturbed Immune Homeostasis in Patients With Chronic Obstructive Pulmonary Disease. Jia Hou, Yongchang Sun. Front Immunol, 2020 May 16; 11. PMID: 32411140 Free PMC article. Review.
Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer. Mengxiao Xie, Jia Wei, Jian Xu. Front Immunol, 2020 May 20; 11. PMID: 32425930 Free PMC article. Review.
Comparative Analysis of Thymic and Blood Treg in Myasthenia Gravis: Thymic Epithelial Cells Contribute to Thymic Immunoregulatory Defects. Frédérique Truffault, Dani Nazzal, +6 authors, Sonia Berrih-Aknin. less Front Immunol, 2020 May 22; 11. PMID: 32435245 Free PMC article.
The Migratory Properties and Numbers of T Regulatory Cell Subsets in Circulation Are Differentially Influenced by Season and Are Associated With Vitamin D Status. Abigail A Lamikanra, Hoi Pat Tsang, +4 authors, David J Roberts. less Front Immunol, 2020 Jun 09; 11. PMID: 32508805 Free PMC article.
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases. Naganari Ohkura, Shimon Sakaguchi. Cell Res, 2020 May 06; 30(6). PMID: 32367041 Free PMC article. Review.
Immune-checkpoint molecules on regulatory T-cells as a potential therapeutic target in head and neck squamous cell cancers. Susumu Suzuki, Tetsuya Ogawa, +7 authors, Toyonori Tsuzuki. less Cancer Sci, 2020 Apr 19; 111(6). PMID: 32304268 Free PMC article.
Transient antibody targeting of CD45RC inhibits the development of graft-versus-host disease. Laetitia Boucault, Maria-Dolores Lopez Robles, +17 authors, Carole Guillonneau. less Blood Adv, 2020 Jun 09; 4(11). PMID: 32511714 Free PMC article.
HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1α pathway in acute lung allograft rejection in mice. Wenyong Zhou, Jun Yang, +7 authors, Xiaofeng Chen. less Theranostics, 2020 Jun 20; 10(15). PMID: 32550904 Free PMC article.
Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins. Aazam Ghelani, Darren Bates, +6 authors, Sue J Sohn. less Front Immunol, 2020 Jun 26; 11. PMID: 32582190 Free PMC article.
In-depth immune cellular profiling reveals sex-specific associations with frailty. Leonard Daniël Samson, A Mieke H Boots, +6 authors, Peter Engelfriet. less Immun Ageing, 2020 Jun 26; 17. PMID: 32582361 Free PMC article.
Transplantation tolerance in nonhuman primates and humans. Megan Sykes, Adam D Griesemer. Bone Marrow Transplant, 2019 Aug 23; 54(Suppl 2). PMID: 31431694 Free PMC article. Review.
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients. Nicolas Gonzalo Núñez, Jimena Tosello Boari, +18 authors, Eliane Piaggio. less Nat Commun, 2020 Jul 01; 11(1). PMID: 32601304 Free PMC article.
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Andrea Cossarizza, Hyun-Dong Chang, +433 authors, Arturo Zychlinsky. less Eur J Immunol, 2019 Oct 22; 49(10). PMID: 31633216 Free PMC article. Highly Cited.
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Rebeca Arroyo Hornero, Christos Georgiadis, +8 authors, Joanna Hester. less Commun Biol, 2020 Jul 16; 3(1). PMID: 32665635 Free PMC article.
The human tissue-resident CCR5+ T cell compartment maintains protective and functional properties during inflammation. Amanda S Woodward Davis, Hayley N Roozen, +15 authors, Martin Prlic. less Sci Transl Med, 2019 Dec 06; 11(521). PMID: 31801887 Free PMC article.
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Adrienne M Luoma, Shengbao Suo, +13 authors, Kai W Wucherpfennig. less Cell, 2020 Jul 01; 182(3). PMID: 32603654 Free PMC article.
Generation of Human Regulatory T Cell Clones. Johannes Nowatzky, Olivier Manches. J Vis Exp, 2020 Jun 02; (159). PMID: 32478733 Free PMC article.
Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma. Kazushige Koike, Hironari Dehari, +10 authors, Akihiro Miyazaki. less PLoS One, 2020 Aug 14; 15(8). PMID: 32785290 Free PMC article.
Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection. Jingyi Yang, Ejuan Zhang, +11 authors, Huimin Yan. less Virol Sin, 2020 Aug 22; 35(6). PMID: 32822061 Free PMC article.
Regulatory T Cells: An Emerging Player in Radiation-Induced Lung Injury. Tiantian Guo, Liqing Zou, +4 authors, Zhengfei Zhu. less Front Immunol, 2020 Aug 28; 11. PMID: 32849634 Free PMC article. Review.
Rational design of anti-GITR-based combination immunotherapy. Roberta Zappasodi, Cynthia Sirard, +16 authors, Taha Merghoub. less Nat Med, 2019 May 01; 25(5). PMID: 31036879 Free PMC article. Highly Cited.
Tissue regulatory T cells. Prudence PokWai Lui, Inchul Cho, Niwa Ali. Immunology, 2020 May 29; 161(1). PMID: 32463116 Free PMC article. Review.
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD. Yuki Imura, Makoto Ando, +2 authors, Taisuke Kondo, Minako Ito, Akihiko Yoshimura. less JCI Insight, 2020 Jun 12; 5(14). PMID: 32525846 Free PMC article.
Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol. Katherine N MacDonald, Sabine Ivison, +12 authors, Megan K Levings. less Cytotherapy, 2019 Dec 08; 21(12). PMID: 31810768 Free PMC article.
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. Francis M Grant, Jie Yang, +15 authors, Rahul Roychoudhuri. less J Exp Med, 2020 Jun 10; 217(9). PMID: 32515782 Free PMC article.
Human regulatory T cells (Treg) and their response to cancer. Theresa L Whiteside. Expert Rev Precis Med Drug Dev, 2019 Jan 01; 4(4). PMID: 32953989 Free PMC article.
Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co-culture system. Pascal Ickrath, Agmal Scherzad, +3 authors, Stephan Hackenberg. less Biomed Rep, 2019 Feb 06; 10(2). PMID: 30719290 Free PMC article.
Bevacizumab-Based Chemotherapy Triggers Immunological Effects in Responding Multi-Treated Recurrent Ovarian Cancer Patients by Favoring the Recruitment of Effector T Cell Subsets. Chiara Napoletano, Ilary Ruscito, +7 authors, Marianna Nuti. less J Clin Med, 2019 Mar 21; 8(3). PMID: 30889935 Free PMC article.
Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients. Michela Cangemi, Barbara Montico, +2 authors, Damiana A Faè, Agostino Steffan, Riccardo Dolcetti. less Front Oncol, 2019 Apr 12; 9. PMID: 30972289 Free PMC article. Review.
Significant association of CD4+CD25+Foxp3+ regulatory T cells with clinical findings in patients with systemic lupus erythematosus. Xiaofan Yang, Weiwen Wang, +6 authors, Huijuan Wang. less Ann Transl Med, 2019 Apr 26; 7(5). PMID: 31019943 Free PMC article.
Turning the Tide Against Regulatory T Cells. SeongJun Han, Aras Toker, Zhe Qi Liu, Pamela S Ohashi. Front Oncol, 2019 May 07; 9. PMID: 31058083 Free PMC article. Review.
A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system. Aude Burlion, Rodrigo N Ramos, +7 authors, Gilles Marodon. less Oncoimmunology, 2019 May 31; 8(7). PMID: 31143518 Free PMC article.
Smoking, immunity, and DNA damage. Nise H Yamaguchi. Transl Lung Cancer Res, 2019 Jun 19; 8(Suppl 1). PMID: 31211100 Free PMC article.
Analysis of Regulatory T Cell Subsets and Their Expression of Helios and PD-1 in Patients with Hashimoto Thyroiditis. Yifang Hu, Lijuan Zhang, +5 authors, Dai Cui. less Int J Endocrinol, 2019 Jun 20; 2019. PMID: 31214258 Free PMC article.
Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people. I Herrero-Fernández, I Rosado-Sánchez, +11 authors, Y M Pacheco. less Immun Ageing, 2019 Jul 18; 16. PMID: 31312227 Free PMC article.
Intestinal CD4 Depletion in HIV / SIV Infection. Ronald S Veazey. Curr Immunol Rev, 2019 Aug 23; 15(1). PMID: 31431807 Free PMC article.
Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study. Erik Boberg, Lena von Bahr, +7 authors, Katarina Le Blanc. less Stem Cells Transl Med, 2020 Jun 24; 9(10). PMID: 32573983 Free PMC article.
FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells. Lucia Campos Carrascosa, Adriaan A van Beek, +19 authors, Jaap Kwekkeboom. less J Immunother Cancer, 2020 Sep 10; 8(2). PMID: 32900860 Free PMC article.
Treatment of intestinal graft-versus-host disease with unrelated donor fecal microbiota transplantation capsules: A case report. Dan Mao, Qi Jiang, +6 authors, Lixia Sheng. less Medicine (Baltimore), 2020 Sep 23; 99(38). PMID: 32957333 Free PMC article.
Tracking immunodynamics by identification of S-G2/M-phase T cells in human peripheral blood. Miguel Muñoz-Ruiz, Irma Pujol-Autonell, +6 authors, Francesca Di Rosa. less J Autoimmun, 2020 May 18; 112. PMID: 32414606 Free PMC article.
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs. Judith Wienke, Laura Brouwers, +5 authors, Femke van Wijk. less JCI Insight, 2020 Aug 19; 5(18). PMID: 32809975 Free PMC article.
Immune Tolerance Induction Using Cell-Based Strategies in Liver Transplantation: Clinical Perspectives. Pusen Wang, Zhongyi Jiang, +4 authors, Lin Zhong. less Front Immunol, 2020 Oct 06; 11. PMID: 33013824 Free PMC article. Review.
Metabolic Optimisation of Regulatory T Cells in Transplantation. Mo Atif, Audrey Mohr, +3 authors, Makoto Miyara. less Front Immunol, 2020 Oct 06; 11. PMID: 33013855 Free PMC article. Review.
Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf. Massimo Claudio Fantini, Agnese Favale, Sara Onali, Federica Facciotti. Int J Mol Sci, 2020 Sep 18; 21(18). PMID: 32937953 Free PMC article. Review.
Mogamulizumab for adult T-cell leukemia-lymphoma: a multicenter prospective observational study. Kentaro Yonekura, Shigeru Kusumoto, +18 authors, Takashi Ishida. less Blood Adv, 2020 Oct 23; 4(20). PMID: 33091125 Free PMC article.
Intrahepatic TH17/TReg Cells in Homeostasis and Disease-It's All About the Balance. Hannah K Drescher, Lea M Bartsch, Sabine Weiskirchen, Ralf Weiskirchen. Front Pharmacol, 2020 Oct 31; 11. PMID: 33123017 Free PMC article. Review.
Transcriptional regulation of Treg homeostasis and functional specification. Ke Wang, Wenxian Fu. Cell Mol Life Sci, 2020 May 01; 77(21). PMID: 32350553 Free PMC article. Review.
A Comparison of Automated Perfusion- and Manual Diffusion-Based Human Regulatory T Cell Expansion and Functionality Using a Soluble Activator Complex. Mark Jones, Brian Nankervis, +3 authors, Claire Coeshott. less Cell Transplant, 2020 Jul 15; 29. PMID: 32662685 Free PMC article.
The immune system in infants: Relevance to xenotransplantation. Mohamed Bikhet, Mahmoud Morsi, +5 authors, Hayato Iwase. less Pediatr Transplant, 2020 Aug 28; 24(7). PMID: 32845539 Free PMC article. Review.
Changes in peripheral immune populations during pregnancy and modulation by probiotics and ω-3 fatty acids. A Forsberg, T R Abrahamsson, +3 authors, L Nilsson, J Ernerudh, K Duchén, M C Jenmalm. less Sci Rep, 2020 Nov 01; 10(1). PMID: 33127947 Free PMC article.
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[Genetically modified regulatory T cells: therapeutic concepts and regulatory aspects]. Attila Sebe, Brigitte Anliker, Juliane Rau, Matthias Renner. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2020 Oct 18; 63(11). PMID: 33067665 Free PMC article. Review.
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Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19. Julika Neumann, Teresa Prezzemolo, +12 authors, Stephanie Humblet-Baron. less Clin Transl Immunology, 2020 Nov 20; 9(11). PMID: 33209300 Free PMC article.
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ISG15 protects human Tregs from interferon alpha-induced contraction in a cell-intrinsic fashion. Ilenia Pacella, Francesca Romana Spinelli, +12 authors, Silvia Piconese. less Clin Transl Immunology, 2020 Dec 31; 9(12). PMID: 33376595 Free PMC article.
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Interleukin-6-mediated CCR9+ interleukin-17-producing regulatory T cells polarization increases the severity of necrotizing enterocolitis. Fei Ma, Sitao Li, +11 authors, Hu Hao. less EBioMedicine, 2019 May 28; 44. PMID: 31129099 Free PMC article.
Immunological Characteristics of Hyperprogressive Disease in Patients with Non-small Cell Lung Cancer Treated with Anti-PD-1/PD-L1 Abs. Kyung Hwan Kim, Joon Young Hur, +9 authors, Eui-Cheol Shin. less Immune Netw, 2021 Jan 12; 20(6). PMID: 33425433 Free PMC article.
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Blunted Expansion of Regulatory T Lymphocytes Is Associated With Increased Bacterial Translocation in Patients With Major Depressive Disorder. Miguel Angel Alvarez-Mon, Ana Maria Gomez-Lahoz, +8 authors, Melchor Alvarez-Mon. less Front Psychiatry, 2021 Jan 26; 11. PMID: 33488424 Free PMC article.
Regulatory T Cells: Concept, Classification, Phenotype, and Biological Characteristics. Yang Du, Qiannan Fang, Song-Guo Zheng. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523440
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Regulatory T Cells for the Induction of Transplantation Tolerance. Weitao Que, Xiao-Kang Li. Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523454
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CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer. Jian Hang Lam, Michelle Hong, +10 authors, Tong Seng Lim. less Cancer Immunol Immunother, 2021 Feb 03; 70(8). PMID: 33527196 Free PMC article.
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment. Varun Sasidharan Nair, Reem Saleh, +2 authors, Salman M Toor, Farhan S Cyprian, Eyad Elkord. less Cancer Immunol Immunother, 2021 Feb 04; 70(8). PMID: 33532902 Free PMC article. Review.
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Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells. Dong Hyun Kim, Hee Young Kim, +7 authors, Won-Woo Lee. less Elife, 2021 Jan 29; 10. PMID: 33507149 Free PMC article.
The Complex Role of Regulatory T Cells in Immunity and Aging. Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Würzner, Birgit Weinberger. Front Immunol, 2021 Feb 16; 11. PMID: 33584708 Free PMC article. Review.
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Regulatory T lymphocyte infiltration in metastatic breast cancer-an independent prognostic factor that changes with tumor progression. Jenny Stenström, Ingrid Hedenfalk, Catharina Hagerling. Breast Cancer Res, 2021 Feb 20; 23(1). PMID: 33602289 Free PMC article.
Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. Maria Xydia, Raheleh Rahbari, +22 authors, Philipp Beckhove. less Nat Commun, 2021 Feb 20; 12(1). PMID: 33602930 Free PMC article.
Immune monitoring in mesothelioma patients identifies novel immune-modulatory functions of gemcitabine associating with clinical response. Floris Dammeijer, Cornedine J De Gooijer, +16 authors, Joachim G Aerts. less EBioMedicine, 2021 Feb 01; 64. PMID: 33516644 Free PMC article.
Non-canonical PD-1 signaling in cancer and its potential implications in clinic. Haoran Zha, Ying Jiang, +10 authors, Zhaoxia Li. less J Immunother Cancer, 2021 Feb 18; 9(2). PMID: 33593825 Free PMC article. Review.
High proportion of terminally differentiated regulatory T cells after allogeneic hematopoietic stem cell transplantation. Caroline Ritacco, Grégory Ehx, +5 authors, Frédéric Baron. less Bone Marrow Transplant, 2021 Mar 06; 56(8). PMID: 33664462
Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Jasmin Quandt, Stephen Arnovitz, +14 authors, Fotini Gounari. less Nat Immunol, 2021 Mar 06; 22(4). PMID: 33664518 Free PMC article.
CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. Aditi Narsale, Breanna Lam, +14 authors, Joanna D Davies. less JCI Insight, 2020 Dec 11; 6(2). PMID: 33301420 Free PMC article.
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells. Ryan Kolb, Umasankar De, +16 authors, Weizhou Zhang. less Nat Commun, 2021 Feb 26; 12(1). PMID: 33627663 Free PMC article.
Plasticity of Treg and imbalance of Treg/Th17 cells in patients with systemic sclerosis modified by FK506. Xinjuan Liu, Yu Wu, +3 authors, Mengtao Li, Jianyu Hao, Qian Wang, Xiaofeng Zeng. less Int J Immunopathol Pharmacol, 2021 Feb 27; 35. PMID: 33631989 Free PMC article.
Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma. Douglas E Joshua, Slavica Vuckovic, +5 authors, Phoebe Joy Ho. less Front Immunol, 2021 Mar 13; 12. PMID: 33708212 Free PMC article. Review.
The Impact of Tregs on the Anticancer Immunity and the Efficacy of Immune Checkpoint Inhibitor Therapies. Jose M González-Navajas, Dengxia Denise Fan, +4 authors, Jongdae Lee. less Front Immunol, 2021 Mar 16; 12. PMID: 33717139 Free PMC article. Review.
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects. Remy Thomas, Ghaneya Al-Khadairi, Julie Decock. Front Oncol, 2021 Mar 16; 10. PMID: 33718107 Free PMC article. Review.
Possible involvement of regulatory T cell abnormalities and variational usage of TCR repertoire in children with autoimmune neutropenia. S Goda, S Hayakawa, +3 authors, S Karakawa, S Okada, H Kawaguchi, M Kobayashi. less Clin Exp Immunol, 2020 Dec 09; 204(1). PMID: 33289074 Free PMC article.
T Cell Subsets During Early Life and Their Implication in the Treatment of Childhood Acute Lymphoblastic Leukemia. Shanie Saghafian-Hedengren, Eva Sverremark-Ekström, Anna Nilsson. Front Immunol, 2021 Mar 26; 12. PMID: 33763058 Free PMC article. Review.
N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells. Yi Sun, Jun Jing, +8 authors, Lu Yang. less J Immunother Cancer, 2021 Mar 12; 9(3). PMID: 33692219 Free PMC article.
A Phase 2 Randomized Placebo-Controlled Adjuvant Trial of GI-4000, a Recombinant Yeast Expressing Mutated RAS Proteins in Patients with Resected Pancreas Cancer. Peter Muscarella, Tanios Bekaii-Saab, +13 authors, David Apelian. less J Pancreat Cancer, 2021 Apr 01; 7(1). PMID: 33786412 Free PMC article.
Function and Role of Regulatory T Cells in Rheumatoid Arthritis. Qi Jiang, Guocan Yang, +2 authors, Qi Liu, Shengjun Wang, Dawei Cui. less Front Immunol, 2021 Apr 20; 12. PMID: 33868244 Free PMC article. Review.
Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology. Julianna Blagih, Marc Hennequart, Fabio Zani. Front Immunol, 2021 Apr 20; 12. PMID: 33868263 Free PMC article. Review.
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Michael Delacher, Malte Simon, +26 authors, Markus Feuerer. less Immunity, 2021 Apr 01; 54(4). PMID: 33789089 Free PMC article.
Inhibition of acid sphingomyelinase increases regulatory T cells in humans. Teresa Wiese, Fabio Dennstädt, +16 authors, Niklas Beyersdorf. less Brain Commun, 2021 Apr 27; 3(2). PMID: 33898989 Free PMC article.
Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications. Yi Dong, Cuiping Yang, Fan Pan. Front Immunol, 2021 Apr 30; 12. PMID: 33912156 Free PMC article. Review.
Immuno-Oncological Biomarkers for Squamous Cell Cancer of the Head and Neck: Current State of the Art and Future Perspectives. Stijn J De Keukeleire, Tijl Vermassen, +3 authors, Sylvie Rottey. less Cancers (Basel), 2021 May 01; 13(7). PMID: 33916646 Free PMC article. Review.
Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased Treg CD25 Expression and Reduced Frequency of Effector Treg Subpopulation. Eunbyeol Go, Su-Jin Yoo, +10 authors, Jaeyul Kwon. less Cells, 2021 May 01; 10(4). PMID: 33916798 Free PMC article.
Standing Variations Modeling Captures Inter-Individual Heterogeneity in a Deterministic Model of Prostate Cancer Response to Combination Therapy. Harsh Vardhan Jain, Inmaculada C Sorribes, +2 authors, Samuel K Handelman, Johnna Barnaby, Trachette L Jackson. less Cancers (Basel), 2021 May 01; 13(8). PMID: 33919753 Free PMC article.
Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation. Gerdien Mijnheer, Lisanne Lutter, +16 authors, Femke van Wijk. less Nat Commun, 2021 May 13; 12(1). PMID: 33976194 Free PMC article.
Age-Related Changes in Thymic Central Tolerance. Jayashree Srinivasan, Jessica N Lancaster, +3 authors, Ellen R Richie. less Front Immunol, 2021 May 11; 12. PMID: 33968086 Free PMC article. Review.
Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells. Nirupama D Verma, Andrew D Lam, +3 authors, Suzanne J Hodgkinson. less Sci Rep, 2021 May 20; 11(1). PMID: 34006899 Free PMC article.
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. Michelle Rosenzwajg, Guillaume Churlaud, +13 authors, David Klatzmann. less J Autoimmun, 2015 Jan 31; 58. PMID: 25634360 Free PMC article. Highly Cited.
Propofol maintains Th17/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p/NFATc2/NF‑κB axis. Can Cui, Dengwen Zhang, +12 authors, Yi Sun. less Int J Mol Med, 2021 May 27; 48(1). PMID: 34036377 Free PMC article.
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Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32. Peter Lehmkuhl, Magdalena Gentz, +3 authors, Alla Skapenko. less Cell Mol Immunol, 2021 Jun 02; 18(7). PMID: 34059789 Free PMC article.
Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment. Priyanka Devi-Marulkar, Carolina Moraes-Cabe, +9 authors, Frédérique Michel. less Front Immunol, 2021 Jun 12; 12. PMID: 34113337 Free PMC article.
Hookworm treatment induces a decrease of suppressive regulatory T cell associated with a Th2 inflammatory response. Virginie Doyen, Francis Corazza, +7 authors, Olivier Michel. less PLoS One, 2021 Jun 11; 16(6). PMID: 34111180 Free PMC article.
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study. Maria A Smolle, Laurin Herbsthofer, +15 authors, Joanna Szkandera. less Br J Cancer, 2021 Jun 16; 125(5). PMID: 34127811 Free PMC article.
Immunological features beyond CD4/CD8 ratio values in older individuals. Vanesa Garrido-Rodríguez, Inés Herrero-Fernández, +9 authors, Yolanda María Pacheco. less Aging (Albany NY), 2021 May 27; 13(10). PMID: 34038386 Free PMC article.
Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer. Daniel R Principe, Lauren Chiec, Nisha A Mohindra, Hidayatullah G Munshi. Front Oncol, 2021 Jun 19; 11. PMID: 34141625 Free PMC article. Review.
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model. Jing Zhou, Yi Lu, Wei Wu, Yunhai Feng. Allergy Asthma Clin Immunol, 2021 Jun 21; 17(1). PMID: 34147127 Free PMC article.
Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment. Yuechen Luo, Changlu Xu, +18 authors, Xiaoming Feng. less Nat Commun, 2021 Jun 25; 12(1). PMID: 34162888 Free PMC article.
Surface Phenotype Changes and Increased Response to Oxidative Stress in CD4+CD25high T Cells. Yoshiki Yamamoto, Takaharu Negoro, +4 authors, Yasuko Nakano. less Biomedicines, 2021 Jun 03; 9(6). PMID: 34072455 Free PMC article.
Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review. Priscila Ferreira Slepicka, Mahboubeh Yazdanifar, Alice Bertaina. Front Immunol, 2021 Jun 29; 12. PMID: 34177941 Free PMC article. Review.
The Tumor Microenvironment of Bladder Cancer. Ken Hatogai, Randy F Sweis. Adv Exp Med Biol, 2020 Jan 01; 1296. PMID: 34185299 Free PMC article.
Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms. Alice Valentin-Torres, Cora Day, +5 authors, Anthony E Ting. less Sci Rep, 2021 Jul 02; 11(1). PMID: 34193955 Free PMC article.
Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD. Aisling M Flinn, Anna Ehrlich, +3 authors, Andrew R Gennery. less J Clin Immunol, 2021 Mar 03; 41(5). PMID: 33651234 Free PMC article.
The Bone Marrow as Sanctuary for Plasma Cells and Memory T-Cells: Implications for Adaptive Immunity and Vaccinology. Stefan A Slamanig, Martijn A Nolte. Cells, 2021 Jul 03; 10(6). PMID: 34203839 Free PMC article. Review.
Gut microbiota-mediated immunomodulation in tumor. Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong. J Exp Clin Cancer Res, 2021 Jul 05; 40(1). PMID: 34217349 Free PMC article. Review.
Regulatory T Cells Increase After rh-MOG Stimulation in Non-Relapsing but Decrease in Relapsing MOG Antibody-Associated Disease at Onset in Children. Philippe Horellou, Aliénor de Chalus, +8 authors, Kumaran Deiva. less Front Immunol, 2021 Jul 06; 12. PMID: 34220827 Free PMC article.
Insights into the biology and therapeutic implications of TNF and regulatory T cells. Benoit L Salomon. Nat Rev Rheumatol, 2021 Jul 07; 17(8). PMID: 34226727 Review.
High preharvest donor Foxp3 mRNA level predicts late relapse of acute lymphoblastic leukaemia after haematopoietic stem cell transplantation. Niels Jacobsen, Tina Frisch, +8 authors, Lars P Ryder. less Eur J Haematol, 2021 Feb 03; 106(5). PMID: 33527553 Free PMC article.
GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function. Rianne Opstelten, Jessica S Suwandi, +10 authors, Derk Amsen. less Eur J Immunol, 2021 Mar 18; 51(6). PMID: 33728639 Free PMC article.
Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer. Koji Inamori, Yosuke Togashi, +13 authors, Hiroyoshi Nishikawa. less JCI Insight, 2021 Mar 24; 6(9). PMID: 33755600 Free PMC article.
Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial. Yifang Hu, Wenwen Feng, +8 authors, Dai Cui. less Clin Transl Sci, 2021 Mar 03; 14(4). PMID: 33650299 Free PMC article.
Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors. Sarah J Dart, Alistair M Cook, +5 authors, Samantha E Bowyer. less Sci Rep, 2021 Jul 30; 11(1). PMID: 34321489 Free PMC article.
Immunohistochemical Expression of FOXP3+ Regulatory T Cells in Proteinuric Primary Glomerulopathies. Georgios Vlachopanos, Argyrios Georgalis, +2 authors, Harikleia Gakiopoulou. less Int J Nephrol, 2021 Aug 03; 2021. PMID: 34336285 Free PMC article.
VX-765 reduces neuroinflammation after spinal cord injury in mice. Jing Chen, Yu-Qing Chen, +8 authors, He-Zuo Lü. less Neural Regen Res, 2021 Jan 30; 16(9). PMID: 33510091 Free PMC article.
Lineage Reprogramming of Effector Regulatory T Cells in Cancer. Michael L Dixon, Jonathan D Leavenworth, Jianmei W Leavenworth. Front Immunol, 2021 Aug 17; 12. PMID: 34394124 Free PMC article. Review.
Expansion of CD45RA-FOXP3++ regulatory T cells is associated with immune tolerance in patients with combined kidney and bone marrow transplantation. Yeongbeen Kwon, Kyo Won Lee, +12 authors, Eui-Cheol Shin. less Clin Transl Immunology, 2021 Aug 18; 10(8). PMID: 34401148 Free PMC article.
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study. Dmitriy Zamarin, Omid Hamid, +6 authors, David S Hong. less Clin Cancer Res, 2020 Jun 27; 26(17). PMID: 32586937 Free PMC article.
Human leukocyte antigen class II-based immune risk model for recurrence evaluation in stage I-III small cell lung cancer. Peixin Chen, Lishu Zhao, +10 authors, Caicun Zhou. less J Immunother Cancer, 2021 Aug 08; 9(8). PMID: 34362829 Free PMC article.
PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity. Alessandro Poli, Shidqiyyah Abdul-Hamid, +7 authors, Nullin Divecha. less Proc Natl Acad Sci U S A, 2021 Jul 28; 118(31). PMID: 34312224 Free PMC article.
Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies. Hiroyoshi Nishikawa, Shohei Koyama. J Immunother Cancer, 2021 Aug 01; 9(7). PMID: 34330764 Free PMC article. Review.
Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism. Wei Li, Minghao Gong, +10 authors, Laurence Morel. less JCI Insight, 2021 Jun 23; 6(14). PMID: 34156979 Free PMC article.
Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Harshi Weerakoon, Jasmin Straube, +8 authors, Ailin Lepletier. less Clin Transl Immunology, 2021 Sep 11; 10(9). PMID: 34504692 Free PMC article.
Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and Challenges. Mehrdad Hefazi, Sara Bolivar-Wagers, Bruce R Blazar. Int J Mol Sci, 2021 Sep 29; 22(18). PMID: 34575843 Free PMC article. Review.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Myung-Chul Kim, Nicholas Borcherding, +32 authors, Weizhou Zhang. less Nat Commun, 2021 Oct 03; 12(1). PMID: 34599187 Free PMC article.
Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease. Katie L Alexander, Qing Zhao, +4 authors, Charles O Elson. less Gastroenterology, 2021 Apr 13; 161(2). PMID: 33844987 Free PMC article.
The fellowship of regulatory and tissue-resident memory cells. Leandro Barros, Cristina Ferreira, Marc Veldhoen. Mucosal Immunol, 2021 Oct 06; 15(1). PMID: 34608235 Free PMC article. Review.
Regulatory T cells in COVID-19. Huan Wang, Zhao Wang, +3 authors, Wen Cao, Qianqian Wu, Yujia Yuan, Xiangjian Zhang. less Aging Dis, 2021 Oct 12; 12(7). PMID: 34631206 Free PMC article.
The Multifaceted Role of Regulatory T Cells in Breast Cancer. Kevin Kos, Karin E de Visser. Annu Rev Cancer Biol, 2021 Oct 12; 5. PMID: 34632244 Free PMC article.
T cells in primary Sjögren's syndrome: targets for early intervention. Gwenny M Verstappen, Frans G M Kroese, Hendrika Bootsma. Rheumatology (Oxford), 2019 Feb 17;. PMID: 30770920 Free PMC article.
Regulatory T-Cells and Multiple Myeloma: Implications in Tumor Immune Biology and Treatment. Christina Hadjiaggelidou, Eirini Katodritou. J Clin Med, 2021 Oct 14; 10(19). PMID: 34640606 Free PMC article. Review.
Follicular helper and follicular regulatory T cell subset imbalance is associated with higher activated B cells and abnormal autoantibody production in primary anti-phospholipid syndrome patients. Yan Long, Wenyi Li, +5 authors, Chen Liu. less Clin Exp Immunol, 2021 Jul 27; 206(2). PMID: 34309827 Free PMC article.
Cellular signaling pathways of T cells in giant cell arteritis. Hai-Yan Li, Jun-Nan Xu, Zong-Wen Shuai. J Geriatr Cardiol, 2021 Oct 19; 18(9). PMID: 34659383 Free PMC article.
The Responsiveness of Bee Venom Phospholipase A2 on Regulatory T Cells Correlates with the CD11c+CD206+Population in Human Peripheral Blood Mononuclear Cells. Heejin Jo, Hyunjung Baek, +4 authors, Sang-Soo Nam. less Toxins (Basel), 2021 Oct 23; 13(10). PMID: 34679010 Free PMC article.
What Are the Biomarkers for Immunotherapy in SCLC? Vito Longo, Annamaria Catino, +7 authors, Domenico Galetta. less Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681779 Free PMC article. Review.
Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody. Ikumi Katano, Asami Hanazawa, +7 authors, Takeshi Takahashi. less Sci Rep, 2021 Oct 28; 11(1). PMID: 34702924 Free PMC article.
Regulatory T-Cell Therapy in Liver Transplantation and Chronic Liver Disease. Angus Hann, Ye H Oo, M Thamara P R Perera. Front Immunol, 2021 Nov 02; 12. PMID: 34721383 Free PMC article. Review.
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction. Baptiste Lamarthée, Armance Marchal, +20 authors, Julien Zuber. less Nat Commun, 2021 Nov 10; 12(1). PMID: 34750385 Free PMC article.
Postoperative Natural Killer Cell Dysfunction: The Prime Suspect in the Case of Metastasis Following Curative Cancer Surgery. Marisa Market, Gayashan Tennakoon, Rebecca C Auer. Int J Mol Sci, 2021 Nov 14; 22(21). PMID: 34768810 Free PMC article. Review.
The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B-cell lymphoma and enhances T-cell recruitment. Hepei Yuan, Momoko Nishikori, +3 authors, Akifumi Takaori-Kondo. less Cancer Sci, 2021 Aug 28; 112(11). PMID: 34449935 Free PMC article.
Circulating Immunosuppressive Regulatory T Cells Predict Risk of Incident Cutaneous Squamous Cell Carcinoma. Dana E Rollison, Jane L Messina, +8 authors, Pearlie K Epling-Burnette. less Front Med (Lausanne), 2021 Nov 20; 8. PMID: 34796183 Free PMC article.
Targeting regulatory T cells for immunotherapy in melanoma. Lili Huang, Yeye Guo, +4 authors, Xiaowei Xu. less Mol Biomed, 2021 Nov 23; 2(1). PMID: 34806028 Free PMC article. Review.
Reduction of Oxidative Stress in Peripheral Blood Mononuclear Cells Attenuates the Inflammatory Response of Fibroblast-like Synoviocytes in Rheumatoid Arthritis. Ha-Reum Lee, Su-Jin Yoo, +2 authors, Jinhyun Kim, Chan Keol Park, Seong Wook Kang. less Int J Mol Sci, 2021 Nov 28; 22(22). PMID: 34830290 Free PMC article.
The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed. Astri Frafjord, Linn Buer, +6 authors, Alexandre Corthay. less Front Immunol, 2021 Dec 07; 12. PMID: 34868011 Free PMC article.
The Role of Diverse Immune Cells in Sarcoidosis. Hui Zhang, Ulrich Costabel, Huaping Dai. Front Immunol, 2021 Dec 07; 12. PMID: 34868074 Free PMC article. Review.
Identification and Validation of 17-lncRNA Related to Regulatory T Cell Heterogeneity as a Prognostic Signature for Head and Neck Squamous Cell Carcinoma. Qi Sun, Yumei Li, +4 authors, Xicheng Song. less Front Immunol, 2021 Dec 10; 12. PMID: 34880875 Free PMC article.
Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia. Yuki Fujioka, Daisuke Sugiyama, +8 authors, Naoto Takahashi. less Cancers (Basel), 2021 Dec 11; 13(23). PMID: 34885012 Free PMC article.
High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease. Lucie Aubergeon, Matthieu Sawaf, +3 authors, Fanny Monneaux. less Front Immunol, 2021 Dec 14; 12. PMID: 34899718 Free PMC article.
Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab. Yuka Maeda, Hisashi Wada, +17 authors, Hiroyoshi Nishikawa. less Nat Commun, 2021 Dec 16; 12(1). PMID: 34907192 Free PMC article.
Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor. Bruce M Hall, Rachael M Hall, +7 authors, Suzanne J Hodgkinson. less Front Immunol, 2021 Dec 17; 12. PMID: 34912327 Free PMC article.
HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma. Benjy Jy Tan, Kenji Sugata, +17 authors, Yorifumi Satou. less J Clin Invest, 2021 Dec 16; 131(24). PMID: 34907908 Free PMC article.
Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors. Takuro Saito, Koji Kurose, +11 authors, Hisashi Wada. less Nagoya J Med Sci, 2021 Dec 18; 83(4). PMID: 34916725 Free PMC article.
Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis. Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake. J Clin Med, 2021 Dec 25; 10(24). PMID: 34945203 Free PMC article. Review.
Th17/Treg Imbalance in Chronic Obstructive Pulmonary Disease: Clinical and Experimental Evidence. Juliana Dias Lourenço, Juliana Tiyaki Ito, +2 authors, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes. less Front Immunol, 2021 Dec 28; 12. PMID: 34956243 Free PMC article. Review.
Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia. Takashi Mikami, Itaru Kato, +22 authors, Junko Takita. less Cancer Sci, 2021 Oct 31; 113(1). PMID: 34716967 Free PMC article.
Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives. Manuel Alfredo Podestà, Megan Sykes. Front Immunol, 2022 Jan 25; 12. PMID: 35069574 Free PMC article. Review.
Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis. Ignatius Ryan Adriawan, Faranaz Atschekzei, +7 authors, Georgios Sogkas. less Ann Rheum Dis, 2021 Sep 30; 81(1). PMID: 34583923 Free PMC article.
Vitamin D can reduce severity in COVID-19 through regulation of PD-L1. Hatice Aygun. Naunyn Schmiedebergs Arch Pharmacol, 2022 Feb 01; 395(4). PMID: 35099571 Free PMC article. Review.
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer. Lei Wang, Diana L Simons, +9 authors, Peter P Lee. less Nat Immunol, 2019 Jul 10; 20(9). PMID: 31285626 Free PMC article. Highly Cited.
Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination. George Elias, Pieter Meysman, +16 authors, Benson Ogunjimi. less Elife, 2022 Jan 26; 11. PMID: 35074048 Free PMC article.
The Prognostic Value of FoxP3+ Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+ Cytotoxic T Cell Density. Sören Schnellhardt, Johannes Hirneth, +5 authors, Luitpold Distel. less Front Immunol, 2022 Feb 11; 13. PMID: 35140715 Free PMC article.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. Yujiro Kidani, Wataru Nogami, +39 authors, Shimon Sakaguchi. less Proc Natl Acad Sci U S A, 2022 Feb 11; 119(7). PMID: 35140181 Free PMC article.
CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer. Ling Yi, Xin Jin, +8 authors, Hongtao Zhang. less Front Immunol, 2022 Feb 25; 13. PMID: 35197968 Free PMC article.
The immune microenvironment in gastric adenocarcinoma. Yana Zavros, Juanita L Merchant. Nat Rev Gastroenterol Hepatol, 2022 Mar 16;. PMID: 35288702 Review.
Regulatory T Cells in Autoimmune Vasculitis. Ke Jin, Simon Parreau, +4 authors, Cornelia M Weyand. less Front Immunol, 2022 Mar 18; 13. PMID: 35296082 Free PMC article. Review.
DNA Methylation of T Lymphocytes as a Therapeutic Target: Implications for Rheumatoid Arthritis Etiology. Jianan Zhao, Kai Wei, +5 authors, Dongyi He. less Front Immunol, 2022 Mar 22; 13. PMID: 35309322 Free PMC article. Review.
Editorial: The Spectrum of Treg Subsets in Transplantation: Immune Regulation and Tolerance Induction. Mousa Mohammadnia-Afrouzi, Mohammad Mirzakhani, +2 authors, Mehdi Shahbazi, Iuliia Kotko, Hans-Dieter Volk. less Front Immunol, 2022 Mar 22; 13. PMID: 35309335 Free PMC article.
Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1. Raquel Matavele Chissumba, Cacildo Magul, +11 authors, RV363 Study Group. less BMC Immunol, 2022 Mar 16; 23(1). PMID: 35287587 Free PMC article.
Cyclosporine Monotherapy in Pediatric Patients With Non-severe Aplastic Anemia: A Retrospective Analysis. Hongmin Li, Lingling Fu, +3 authors, Bixi Yang, Hui Chen, Jie Ma, Runhui Wu. less Front Med (Lausanne), 2022 Mar 29; 9. PMID: 35342744 Free PMC article.
Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis. Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong. J Immunol Res, 2022 Apr 06; 2022. PMID: 35378904 Free PMC article. Review.
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma. Galabina Bozhanova, Jehanne Hassan, +19 authors, Alan Melcher. less J Immunother Cancer, 2022 Mar 27; 10(3). PMID: 35338089 Free PMC article.
[Efficacy of stanozolol and danazol in the treatment of non-severe aplastic anemia and their effects on CD4(+)CD25(+)Foxp3(+) regulatory T cells]. H M Li, Z B Long, T Wang, B Han. Zhonghua Xue Ye Xue Za Zhi, 2022 Apr 06; 43(2). PMID: 35381679 Free PMC article.
Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders - Advances and challenges. Tapas Kumar Goswami, Mithilesh Singh, +7 authors, Kuldeep Dhama. less Hum Vaccin Immunother, 2022 Mar 05; 18(1). PMID: 35240914 Free PMC article. Review.
Mucosal Immune Responses to Respiratory Syncytial Virus. Megan V C Barnes, Peter J M Openshaw, Ryan S Thwaites. Cells, 2022 Apr 13; 11(7). PMID: 35406717 Free PMC article. Review.
Patient-Derived Avatar Mouse Model to Predict the Liver Immune Homeostasis of Long-Term Stable Liver Transplant Patients. Soon Kyu Lee, Min-Jung Park, +10 authors, Mi-La Cho. less Front Immunol, 2022 Apr 15; 13. PMID: 35418987 Free PMC article.
Diagnosis and Treatment of a Patient With Severe Combined Immunodeficiency Due to a Novel Homozygous Mutation in the IL-7Rα Chain. Rana Mansour, Yasmin El Bsat, +6 authors, Michel J Massaad. less Front Immunol, 2022 Apr 15; 13. PMID: 35418989 Free PMC article.
Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 cases. Abdurrahman Simsek, Muhammed A Kizmaz, +11 authors, Ferah Budak. less J Med Virol, 2022 Jan 16; 94(5). PMID: 35032133 Free PMC article.
Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancer. Sho Sato, Hirokazu Matsushita, +7 authors, Kosei Hasegawa. less BMC Cancer, 2022 Apr 23; 22(1). PMID: 35449092 Free PMC article.
Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation. Kevin Louis, Paul Fadakar, +7 authors, Diana Metes. less Kidney Int, 2022 Jan 30; 101(5). PMID: 35090879 Free PMC article.
Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity. Zhongyi Jiang, Haitao Zhu, +4 authors, Futian Du. less MedComm (2020), 2022 Apr 28; 3(2). PMID: 35474948 Free PMC article. Review.
Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry. Sebastian Jarosch, Jan Köhlen, +7 authors, Dirk H Busch. less Cell Rep Methods, 2022 Apr 28; 1(7). PMID: 35475000 Free PMC article.
Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma. Jose R Cortes, Ioan Filip, +18 authors, Teresa Palomero. less Cell Rep, 2022 Apr 21; 39(3). PMID: 35443168 Free PMC article.
Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19. Alhasan Alsalman, Mohammad A Al-Mterin, Eyad Elkord. J Immunol Res, 2022 May 03; 2022. PMID: 35497875 Free PMC article. Review.
The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer. Noriko Goda, Shinsuke Sasada, +6 authors, Takayuki Kadoya. less Discov Oncol, 2022 Apr 20; 13(1). PMID: 35438346 Free PMC article.
Immune effects of CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer: Relief from immunosuppression is associated with clinical response. Fabio Scirocchi, Simone Scagnoli, +9 authors, Marianna Nuti. less EBioMedicine, 2022 Apr 28; 79. PMID: 35477069 Free PMC article.
Transplant Tolerance, Not Only Clonal Deletion. Bruce M Hall, Nirupama D Verma, Giang T Tran, Suzanne J Hodgkinson. Front Immunol, 2022 May 10; 13. PMID: 35529847 Free PMC article. Review.
Comparison of Whole Blood Cryopreservation Methods for Extensive Flow Cytometry Immunophenotyping. Valentina Serra, Valeria Orrù, +4 authors, Edoardo Fiorillo. less Cells, 2022 May 15; 11(9). PMID: 35563832 Free PMC article.
The Effect of Intratumoral Interrelation among FOXP3+ Regulatory T Cells on Treatment Response and Survival in Triple-Negative Breast Cancer. Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki. Cancers (Basel), 2022 May 15; 14(9). PMID: 35565267 Free PMC article.
The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value. Vanessa Desantis, Francesco Domenico Savino, +5 authors, Monica Montagnani. less J Clin Med, 2022 May 15; 11(9). PMID: 35566637 Free PMC article. Review.
Effector Memory T Cells and CD45RO+ Regulatory T Cells in Metastatic vs. Non-Metastatic Lymph Nodes in Lung Cancer Patients. Iwona Kwiecień, Elżbieta Rutkowska, +5 authors, Joanna Domagała-Kulawik. less Front Immunol, 2022 May 20; 13. PMID: 35585972 Free PMC article.
Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis. Rui Zhang, Jinlin Miao, +5 authors, Ping Zhu. less Front Immunol, 2022 May 24; 13. PMID: 35603149 Free PMC article.
Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease. N Richardson, G E Wootton, A G Bozward, Y H Oo. Semin Immunopathol, 2022 Jun 01;. PMID: 35641679 Review.
Associations of different immune checkpoints-expressing CD4+ Treg/ T cell subsets with disease-free survival in colorectal cancer patients. Mohammad A Al-Mterin, Khaled Murshed, +2 authors, Alhasan Alsalman, Ala Abu-Dayeh, Eyad Elkord. less BMC Cancer, 2022 Jun 03; 22(1). PMID: 35655158

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