Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009

A Goldhirsch ¹, J N Ingle , R D Gelber , A S Coates , B Thürlimann , H-J Senn , Panel members

Affiliations

¹ International Breast Cancer Study Group, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. aron.goldhirsch@ibcsg.org

PMID: 19535820
64 References
367 citations

Abstract

The 11(th) St Gallen (Switzerland) expert consensus meeting on the primary treatment of early breast cancer in March 2009 maintained an emphasis on targeting adjuvant systemic therapies according to subgroups defined by predictive markers. Any positive level of estrogen receptor (ER) expression is considered sufficient to justify the use of endocrine adjuvant therapy in almost all patients. Overexpression or amplification of HER2 by standard criteria is an indication for anti-HER2 therapy for all but the very lowest risk invasive tumours. The corollary is that ER and HER2 must be reliably and accurately measured. Indications for cytotoxic adjuvant therapy were refined, acknowledging the role of risk factors with the caveat that risk per se is not a target. Proliferation markers, including those identified in multigene array analyses, were recognised as important in this regard. The threshold for indication of each systemic treatment modality thus depends on different criteria which have been separately listed to clarify the therapeutic decision-making algorithm.

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Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer. Meredith M Regan, Karen N Price, +3 authors, International Breast Cancer Study Group and BIG 1-98 Collaborative Group. less Breast Cancer Res, 2011 Jun 04; 13(3). PMID: 21635709 Free PMC article. Review.
Different annual recurrence pattern between lumpectomy and mastectomy: implication for breast cancer surveillance after breast-conserving surgery. Ke-Da Yu, Shuang Li, Zhi-Ming Shao. Oncologist, 2011 Jun 18; 16(8). PMID: 21680575 Free PMC article.
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. A Goldhirsch, W C Wood, +4 authors, Panel members. less Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140 Free PMC article. Highly Cited.
Clinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes. Deirdre P Cronin-Fenton, Timothy L Lash. Expert Rev Clin Pharmacol, 2011 Jun 29; 4(3). PMID: 21709817 Free PMC article. Review.
Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53. E K A Millar, P H Graham, +10 authors, R L Sutherland. less Br J Cancer, 2011 Jun 30; 105(2). PMID: 21712826 Free PMC article.
Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study. Szu-Erh Chan, Hung-Wen Lai, +4 authors, Dar-Ren Chen. less Evid Based Complement Alternat Med, 2011 Jul 01; 2011. PMID: 21716682 Free PMC article.
Immune effects of trastuzumab. Marianna Nuti, Filippo Bellati, +8 authors, Aurelia Rughetti. less J Cancer, 2011 Jul 01; 2. PMID: 21716848 Free PMC article.
A simple method for assigning genomic grade to individual breast tumours. Kristian Wennmalm, Jonas Bergh. BMC Cancer, 2011 Jul 23; 11. PMID: 21777443 Free PMC article.
Adjuvant Systemic Therapy of Breast Cancer. Florian Schuetz. Breast Care (Basel), 2011 Jul 23; 6(3). PMID: 21779222 Free PMC article.
Prognostic and Predictive Markers for Treatment Decisions in Early Breast Cancer. Elmar Stickeler. Breast Care (Basel), 2011 Jul 23; 6(3). PMID: 21779224 Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction. Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho. Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441 Free PMC article. Review.
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), C Davies, +11 authors, R Peto. less Lancet, 2011 Aug 02; 378(9793). PMID: 21802721 Free PMC article. Highly Cited.
Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Anders Carlsson, Christer Wingren, +10 authors, Carl A K Borrebaeck. less Proc Natl Acad Sci U S A, 2011 Aug 17; 108(34). PMID: 21844363 Free PMC article.
The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause. Jacquie Chirgwin, Zhuoxin Sun, +8 authors, BIG 1-98 Collaborative and International Breast Cancer Study Groups. less Breast Cancer Res Treat, 2011 Sep 06; 131(1). PMID: 21892704 Free PMC article.
Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score. Arif H Kamal, Charles L Loprinzi, +7 authors, Matthew P Goetz. less Oncologist, 2011 Sep 22; 16(10). PMID: 21934103 Free PMC article.
Pharmacoeconomic considerations in the treatment of breast cancer. Athanasios Pallis, Vasiliki Tsiantou, Efi Simou, Nikos Maniadakis. Clinicoecon Outcomes Res, 2010 Jan 01; 2. PMID: 21935314 Free PMC article.
Prognostic and predictive role of ESR1 status for postmenopausal patients with endocrine-responsive early breast cancer in the Danish cohort of the BIG 1-98 trial. B Ejlertsen, J Aldridge, +10 authors, Danish Breast Cancer Cooperative Group the BIG 1-98 Collaborative Group and the International Breast Cancer Study Group. less Ann Oncol, 2011 Oct 12; 23(5). PMID: 21986093 Free PMC article.
Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer. Rachel C Jankowitz, Kristine Cooper, +5 authors, Adam Brufsky. less Breast Cancer Res, 2011 Oct 18; 13(5). PMID: 21999244 Free PMC article.
Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosis. Reiki Nishimura, Tomofumi Osako, +3 authors, Nobuyuki Arima. less World J Surg Oncol, 2011 Oct 19; 9. PMID: 22004841 Free PMC article.
High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer. E Brain, C Levy, +12 authors, P Fumoleau. less Br J Cancer, 2011 Oct 20; 105(10). PMID: 22009030 Free PMC article.
Degree of variability in performance on breast cancer quality indicators: findings from the Florida initiative for quality cancer care. Jhanelle E Gray, Christine Laronga, +16 authors, Paul B Jacobsen. less J Oncol Pract, 2011 Nov 02; 7(4). PMID: 22043190 Free PMC article.
Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review. Elisabeth Luporsi, Fabrice André, +22 authors, Jean-Pierre Bellocq. less Breast Cancer Res Treat, 2011 Nov 04; 132(3). PMID: 22048814 Free PMC article. Highly Cited. Review.
A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer. Hideo Shigematsu, Takayuki Kadoya, +9 authors, Morihito Okada. less World J Surg Oncol, 2011 Nov 09; 9. PMID: 22059982 Free PMC article.
Exemestane in the adjuvant treatment of breast cancer in postmenopausal women. Muaiad Kittaneh, Stefan Glück. Breast Cancer (Auckl), 2011 Nov 16; 5. PMID: 22084574 Free PMC article.
Zoledronic acid in breast cancer: latest findings and interpretations. Michael Gnant. Ther Adv Med Oncol, 2011 Nov 16; 3(6). PMID: 22084643 Free PMC article.
Paclitaxel-induced peripheral neuropathy in patients receiving adjuvant chemotherapy for breast cancer. Yuko Tanabe, Kenji Hashimoto, +9 authors, Yasuhiro Fujiwara. less Int J Clin Oncol, 2011 Nov 23; 18(1). PMID: 22105895
Glycoprotein profiles of human breast cells demonstrate a clear clustering of normal/benign versus malignant cell lines and basal versus luminal cell lines. Ten-Yang Yen, Bruce A Macher, +2 authors, Leslie C Timpe. less J Proteome Res, 2011 Nov 24; 11(2). PMID: 22106898 Free PMC article.
Zoledronic acid in the treatment of early-stage breast cancer: is there a final verdict? Michael Gnant. Curr Oncol Rep, 2011 Nov 25; 14(1). PMID: 22113793 Review.
The breast cancer genome--a key for better oncology. Hans Kristian Moen Vollan, Carlos Caldas. BMC Cancer, 2011 Dec 02; 11. PMID: 22128823 Free PMC article. Review.
Factors associated with concordant estrogen receptor expression at diagnosis and centralized re-assay in a Danish population-based breast cancer study. Deirdre P Cronin-Fenton, Ylva Hellberg, +7 authors, Stephen Hamilton-Dutoit. less Acta Oncol, 2011 Dec 02; 51(2). PMID: 22129357 Free PMC article.
AGO Recommendations for Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. Update 2011. Christoph Thomssen, Anton Scharl, Nadia Harbeck. Breast Care (Basel), 2011 Dec 14; 6(4). PMID: 22164127 Free PMC article.
Apoptosis - associated genes and their role in predicting responses to neoadjuvant breast cancer treatment. Daniel Tvrdík, Helena Skálová, +5 authors, Luboš Petruželka. less Med Sci Monit, 2011 Dec 31; 18(1). PMID: 22207111 Free PMC article.
Expression of the androgen receptor and its correlation with molecular subtypes in 980 chinese breast cancer patients. Ji-Ping Qi, You-Lin Yang, +11 authors, Ping Tang. less Breast Cancer (Auckl), 2012 Jan 20; 6. PMID: 22259247 Free PMC article.
Role of HER2-Targeted Agents in Adjuvant Treatment for Breast Cancer. Toru Mukohara. Chemother Res Pract, 2012 Feb 02; 2011. PMID: 22295205 Free PMC article.
Phase II trial with letrozole to maximum response as primary systemic therapy in postmenopausal patients with ER/PgR[+] operable breast cancer. Antonio Llombart-Cussac, Ángel Guerrero, +6 authors, Vicente Guillem Porta. less Clin Transl Oncol, 2012 Feb 04; 14(2). PMID: 22301401
Is there any role for new prognostic markers in breast cancer? Agustí Barnadas. Clin Transl Oncol, 2012 Mar 01; 14(3). PMID: 22374417 Review.
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer. Gustaf Rosin, Ulf Hannelius, +4 authors, Juha Kere. less BMC Cancer, 2012 Mar 02; 12. PMID: 22375924 Free PMC article.
Correlations between diffusion-weighted imaging and breast cancer biomarkers. Laura Martincich, Veronica Deantoni, +9 authors, Filippo Montemurro. less Eur Radiol, 2012 Mar 14; 22(7). PMID: 22411304
Capecitabine monotherapy: review of studies in first-line HER-2-negative metastatic breast cancer. Joyce A O'Shaughnessy, Manfred Kaufmann, +4 authors, Nadia Harbeck. less Oncologist, 2012 Mar 16; 17(4). PMID: 22418569 Free PMC article. Review.
Neoadjuvant Therapy - What Have We Achieved in the Last 20 Years? Jens Huober, Gunter von Minckwitz. Breast Care (Basel), 2012 Mar 16; 6(6). PMID: 22419894 Free PMC article.
Trends and Novel Approaches in Neoadjuvant Treatment of Breast Cancer. Guenther G Steger, Rupert Bartsch. Breast Care (Basel), 2012 Mar 16; 6(6). PMID: 22419895 Free PMC article.
Patients with positive axillary lymph nodes: how to use genomic assays. Ruta Rao. Curr Treat Options Oncol, 2012 Mar 20; 13(2). PMID: 22426945
Prognostic value of Bcl-2 in two independent populations of estrogen receptor positive breast cancer patients treated with adjuvant endocrine therapy. Mathilde S Larsen, Karsten Bjerre, +5 authors, Birgitte B Rasmussen. less Acta Oncol, 2012 Apr 03; 51(6). PMID: 22462654 Free PMC article.
A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. Ran Gu, Weijuan Jia, +13 authors, Fengxi Su. less BMC Cancer, 2012 May 03; 12. PMID: 22548922 Free PMC article.
Managing arthralgia in a postmenopausal woman taking an aromatase inhibitor for hormonesensitive early breast cancer: a case study. Jane Bryce, Martina Bauer, Peyman Hadji. Cancer Manag Res, 2012 May 10; 4. PMID: 22570564 Free PMC article.
[Assessment of proliferation: core biopsy or resection specimen? Discrepancies in breast cancer with low and high proliferation]. E C Obermann, S Eppenberger-Castori, C Tapia. Pathologe, 2012 May 12; 33(3). PMID: 22576598 Review.
Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study. Rebecca Ritte, Annekatrin Lukanova, +44 authors, Rudolf Kaaks. less Breast Cancer Res, 2012 May 16; 14(3). PMID: 22583394 Free PMC article.
Should Postmastectomy Radiotherapy to the Chest Wall and Regional Lymph Nodes Be Standard for Patients with 1-3 Positive Lymph Nodes? Birgitte V Offersen, Hans-Jürgen Brodersen, +2 authors, Mette M Nielsen, Jens Overgaard, Marie Overgaard. less Breast Care (Basel), 2012 May 24; 6(5). PMID: 22619643 Free PMC article.
Ductal carcinoma in situ: what can we learn from clinical trials? Lucio Fortunato, Igor Poccia, Ugo de Paula, Elena Santini. Int J Surg Oncol, 2012 Jun 01; 2012. PMID: 22649720 Free PMC article.
How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast- and Gynecopathologists. Zsuzsanna Varga, Joachim Diebold, +16 authors, Hans-Anton Lehr. less PLoS One, 2012 Jun 05; 7(5). PMID: 22662150 Free PMC article.
Fertility preservation in women undergoing treatment for breast cancer in the UK: a questionnaire study. Judy W King, Melanie C Davies, +2 authors, Nicola Roche, Jacinta M Abraham, Alison L Jones. less Oncologist, 2012 Jun 19; 17(7). PMID: 22707514 Free PMC article.
SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer? Maria Tengström, Arto Mannermaa, +2 authors, Veli-Matti Kosma, Ari Hirvonen, Vesa Kataja. less BMC Cancer, 2012 Jun 20; 12. PMID: 22708928 Free PMC article.
A risk score based on histopathological features predicts higher risk of distant recurrence in premenopausal patients with lymph node-negative endocrine-responsive breast cancer. Silvia Dellapasqua, Vincenzo Bagnardi, +9 authors, Marco Colleoni. less Breast, 2012 Jul 04; 21(5). PMID: 22749924 Free PMC article.
Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer. Thomas Decker, Gerhard Fischer, +8 authors, Katharina Götze. less J Cancer Res Clin Oncol, 2012 Jul 05; 138(11). PMID: 22760213
Patterns and risk factors for locoregional failures after mastectomy for breast cancer: an International Breast Cancer Study Group report. P Karlsson, B F Cole, +12 authors, International Breast Cancer Study Group. less Ann Oncol, 2012 Jul 11; 23(11). PMID: 22776708 Free PMC article.
Development of novel breast cancer recurrence prediction model using support vector machine. Woojae Kim, Ku Sang Kim, +5 authors, Rae Woong Park. less J Breast Cancer, 2012 Jul 19; 15(2). PMID: 22807942 Free PMC article.
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Are there biologic differences between male and female breast cancer explaining inferior outcome of men despite equal stage and treatment?! A-C Müller, C Gani, +4 authors, M Weinmann. less Strahlenther Onkol, 2012 Aug 01; 188(9). PMID: 22847517
The prognostic importance of cathepsin D and E-cadherin in early breast cancer: A single-institution experience. Galia Jacobson-Raber, Irena Lazarev, +5 authors, Samuel Ariad. less Oncol Lett, 2012 Aug 01; 2(6). PMID: 22848286 Free PMC article.
A retrospective study on TS mRNA expression and prediction of the effects of adjuvant oral 5-fluorouracil in breast cancer. Fuminori Aki, Yoshimi Bando, +5 authors, Keisuke Izumi. less Oncol Lett, 2010 Nov 01; 1(6). PMID: 22870098 Free PMC article.
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High expression of thymidine phosphorylase in basal-like breast cancers: Stromal expression in EGFR- and/or CK5/6-positive breast cancers. Shinobu Umemura, Masatoshi Shirane, +3 authors, Robert Y Osamura. less Oncol Lett, 2010 Mar 01; 1(2). PMID: 22966291 Free PMC article.
Accuracy validation of adjuvant! online in Taiwanese breast cancer patients--a 10-year analysis. Kuo Yao-Lung, Chen Dar-Ren, Chang Tsai-Wang. BMC Med Inform Decis Mak, 2012 Sep 19; 12. PMID: 22985190 Free PMC article.
Guidelines for locoregional therapy in primary breast cancer in developing countries: The results of an expert panel at the 8(th) Annual Women's Cancer Initiative - Tata Memorial Hospital (WCI-TMH) Conference. Anusheel Munshi, Sudeep Gupta, +12 authors, other Locoregional Panel Members. less Indian J Med Paediatr Oncol, 2012 Sep 19; 33(2). PMID: 22988354 Free PMC article.
The effect of accompanying in situ ductal carcinoma on accuracy of measuring malignant breast tumor size using B-mode ultrasonography and real-time sonoelastography. A A Soliman, S Wojcinski, F Degenhardt. Int J Breast Cancer, 2012 Sep 19; 2012. PMID: 22988516 Free PMC article.
Ki-67 as a prognostic marker according to breast cancer subtype and a predictor of recurrence time in primary breast cancer. Reiki Nishimura, Tomofumi Osako, +3 authors, Nobuyuki Arima. less Exp Ther Med, 2010 Sep 01; 1(5). PMID: 22993598 Free PMC article.
Comparison of evaluations of hormone receptors in breast carcinoma by image-analysis using three automated immunohistochemical stainings. Koji Arihiro, Miyo Oda, +9 authors, Maiko Tanaka. less Exp Ther Med, 2010 Nov 01; 1(6). PMID: 22993620 Free PMC article.
Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breast. Pia Boström, Annele Sainio, +3 authors, Hannu Järveläinen. less Histochem Cell Biol, 2012 Sep 26; 139(1). PMID: 23007289 Free PMC article.
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Patients' choice on axillary lymph node dissection following sentinel lymph node micrometastasis--first report on prospective use of a nomogram in very low risk patients. Gábor Cserni, Istvánné Bezsenyi, László Markó. Pathol Oncol Res, 2012 Oct 17; 19(2). PMID: 23070585
Impact of the american college of surgeons oncology group Z0011 criteria applied to a contemporary patient population. Min Yi, Henry M Kuerer, +6 authors, Kelly K Hunt. less J Am Coll Surg, 2012 Nov 06; 216(1). PMID: 23122536 Free PMC article.
A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen. Galina Lebedeva, Azusa Yamaguchi, +2 authors, Simon P Langdon, Kenneth Macleod, David J Harrison. less BMC Syst Biol, 2012 Nov 09; 6. PMID: 23134774 Free PMC article.
The 21-gene recurrence score assay impacts adjuvant therapy recommendations for ER-positive, node-negative and node-positive early breast cancer resulting in a risk-adapted change in chemotherapy use. W Eiermann, M Rezai, +13 authors, J Blohmer. less Ann Oncol, 2012 Nov 09; 24(3). PMID: 23136233 Free PMC article.
Histone demethylase GASC1--a potential prognostic and predictive marker in invasive breast cancer. Bozena Berdel, Kaisa Nieminen, +5 authors, Arto Mannermaa. less BMC Cancer, 2012 Nov 15; 12. PMID: 23148692 Free PMC article.
Adding hormonal therapy to chemotherapy and trastuzumab improves prognosis in patients with hormone receptor-positive and human epidermal growth factor receptor 2-positive primary breast cancer. Naoki Hayashi, Naoki Niikura, +2 authors, Hideko Yamauchi, Seigo Nakamura, Naoto T Ueno. less Breast Cancer Res Treat, 2012 Nov 28; 137(2). PMID: 23184079 Free PMC article.
Treatment when prognostic factors do not match St. Gallen recommendations: profiling of prognostic factors among HR(+) and HER2(-) breast cancer patients. Kyoko Satoh, Maki Tanaka, +2 authors, Ayako Yano, Jiang Ying, Tatsuyuki Kakuma. less World J Surg, 2012 Dec 12; 37(3). PMID: 23229849
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Adjuvant Hormonal Therapy in Postmenopausal Women with Breast Cancer: Physician's Choices. Asim Jamal Shaikh, Shiyam Kumar, +2 authors, Sajjad Raza, Maria Mehboob, Osama Ishtiaq. less Int J Breast Cancer, 2013 Jan 11; 2012. PMID: 23304528 Free PMC article.
Analysis of the potent prognostic factors in luminal-type breast cancer. Han-Sung Kim, Inseok Park, +7 authors, Young-Duck Kim. less J Breast Cancer, 2013 Jan 25; 15(4). PMID: 23346168 Free PMC article.
The mitochondrial transport protein SLC25A43 affects drug efficacy and drug-induced cell cycle arrest in breast cancer cell lines. Marike Gabrielson, Elisabet Tina. Oncol Rep, 2013 Jan 29; 29(4). PMID: 23354756 Free PMC article.
Elevated BUBR1 expression is associated with poor survival in early breast cancer patients: 15-year follow-up analysis. Adam Maciejczyk, Jolanta Szelachowska, +4 authors, Paweł Surowiak. less J Histochem Cytochem, 2013 Feb 09; 61(5). PMID: 23392733 Free PMC article.
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Long-term prognostic performance of Ki67 rate in early stage, pT1-pT2, pN0, invasive breast carcinoma. Fabien Reyal, David Hajage, +14 authors, Xavier Sastre-Garau. less PLoS One, 2013 Mar 26; 8(3). PMID: 23526930 Free PMC article.
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Long-term analysis to objectify the tumour grading by means of automated microscopic image analysis of the nucleolar organizer regions (AgNORs) in the case of breast carcinoma. Klaus-Jürgen Winzer, Joachim Bellach, Peter Hufnagl. Diagn Pathol, 2013 Apr 10; 8. PMID: 23566354 Free PMC article.
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Tailoring treatment for ductal intraepithelial neoplasia of the breast according to Ki-67 and molecular phenotype. M Lazzeroni, A Guerrieri-Gonzaga, +12 authors, G Pruneri. less Br J Cancer, 2013 Apr 13; 108(8). PMID: 23579208 Free PMC article.
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Identification and validation of a new set of five genes for prediction of risk in early breast cancer. Giorgio Mustacchi, Maria Pia Sormani, +5 authors, Luca Morandi. less Int J Mol Sci, 2013 May 08; 14(5). PMID: 23648477 Free PMC article.
A randomized, double-blind, controlled study of exemestane versus anastrozole for the first-line treatment of postmenopausal Japanese women with hormone-receptor-positive advanced breast cancer. Hiroji Iwata, Norikazu Masuda, +10 authors, Shinzaburo Noguchi. less Breast Cancer Res Treat, 2013 May 30; 139(2). PMID: 23715630 Free PMC article.
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The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions. Berit Maria Müller, Elke Keil, +16 authors, Carsten Denkert. less PLoS One, 2013 Jul 05; 8(6). PMID: 23826382 Free PMC article.
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The variation and clinical significance of hormone receptors and Her-2 status from primary to metastatic lesions in breast cancer patients. Yan-Yun Zhu, Wen Si, +3 authors, Tie-Feng Ji, Xiao-Qin Guo, Yi Hu, Jun-Lan Yang. less Tumour Biol, 2015 Dec 22; 37(6). PMID: 26687919
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The role of postmastectomy radiotherapy in clinically node-positive, stage II-III breast cancer patients with pathological negative nodes after neoadjuvant chemotherapy: an analysis from the NCDB. Jieqiong Liu, Kai Mao, +5 authors, Lisa K Jacobs. less Oncotarget, 2015 Dec 29; 7(17). PMID: 26709538 Free PMC article.
Prognostic impact of progesterone receptor status combined with body mass index in breast cancer patients treated with adjuvant aromatase inhibitor. Masahiro Ohara, Etsushi Akimoto, +4 authors, Toshiyuki Itamoto. less Oncol Lett, 2016 Jan 02; 10(5). PMID: 26722327 Free PMC article.
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Comparisons between glucose analogue 2-deoxy-2-((18)F)fluoro-D-glucose and (18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions. Selene Capitanio, Francesca Bongioanni, +13 authors, Silvia Morbelli. less World J Radiol, 2016 Mar 17; 8(2). PMID: 26981229 Free PMC article.
Prognostic implications of securin expression and sub-cellular localization in human breast cancer. N Gurvits, H Repo, +5 authors, P Kronqvist. less Cell Oncol (Dordr), 2016 Mar 18; 39(4). PMID: 26984614
Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study. Osamu Maeda, Tomoko Miyata-Takata, +6 authors, Fumitaka Kikkawa. less Cancer Med, 2016 Mar 20; 5(6). PMID: 26993048 Free PMC article.
Efficacy and safety of leuprorelin acetate 6-month depot, TAP-144-SR (6M), in combination with tamoxifen in postoperative, premenopausal patients with hormone receptor-positive breast cancer: a phase III, randomized, open-label, parallel-group comparative study. Junichi Kurebayashi, Tatsuya Toyama, +2 authors, Shuuji Sumino, Eri Miyajima, Tsukasa Fujimoto. less Breast Cancer, 2016 Mar 28; 24(1). PMID: 27017207 Free PMC article.
Automated quantification of proliferation with automated hot-spot selection in phosphohistone H3/MART1 dual-stained stage I/II melanoma. Patricia Switten Nielsen, Rikke Riber-Hansen, Henrik Schmidt, Torben Steiniche. Diagn Pathol, 2016 Apr 12; 11. PMID: 27062658 Free PMC article.
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Prognostic value of Ki67 and p53 in patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative breast cancer: Validation of the cut-off value of the Ki67 labeling index as a predictive factor. Masahiro Ohara, Kazuo Matsuura, +5 authors, Toshiyuki Itamoto. less Mol Clin Oncol, 2016 Apr 14; 4(4). PMID: 27073684 Free PMC article.
The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen. Nataliya Babyshkina, Sergey Vtorushin, +7 authors, Evgeny Choynzonov. less Clin Exp Med, 2016 May 27; 17(3). PMID: 27225751
Triple-negative breast cancer: treatment challenges and solutions. Joëlle Collignon, Laurence Lousberg, Hélène Schroeder, Guy Jerusalem. Breast Cancer (Dove Med Press), 2016 Jun 11; 8. PMID: 27284266 Free PMC article. Highly Cited.
Prolactin-induced protein as a potential therapy response marker of adjuvant chemotherapy in breast cancer patients. Karolina Jablonska, Jedrzej Grzegrzolka, +10 authors, Piotr Dziegiel. less Am J Cancer Res, 2016 Jun 14; 6(5). PMID: 27293986 Free PMC article.
An international study comparing conventional versus mRNA level testing (TargetPrint) for ER, PR, and HER2 status of breast cancer. Jelle Wesseling, Corrado Tinterri, +16 authors, Pino Cusumano. less Virchows Arch, 2016 Jul 06; 469(3). PMID: 27377889
Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups. Dvir Netanely, Ayelet Avraham, +2 authors, Adit Ben-Baruch, Ella Evron, Ron Shamir. less Breast Cancer Res, 2016 Jul 09; 18(1). PMID: 27386846 Free PMC article.
Assessment of dual-probe Her-2 fluorescent in situ hybridization in breast cancer by the 2013 ASCO/CAP guidelines produces more equivocal results than that by the 2007 ASCO/CAP guidelines. Xiao-Long Qian, Hannah Y Wen, +6 authors, Li Fu. less Breast Cancer Res Treat, 2016 Jul 28; 159(1). PMID: 27455837 Free PMC article.
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Risk factors for seroma evacuation in breast cancer patients treated with intraoperative radiotherapy. Michał Falco, Bartłomiej Masojć, +6 authors, Andrzej Kram. less Rep Pract Oncol Radiother, 2016 Sep 08; 21(3). PMID: 27601955 Free PMC article.
From High-Throughput Microarray-Based Screening to Clinical Application: The Development of a Second Generation Multigene Test for Breast Cancer Prognosis. Jan C Brase, Ralf Kronenwett, +2 authors, Christoph Petry, Carsten Denkert, Marcus Schmidt. less Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605191 Free PMC article. Review.
Prognostic values of negative estrogen or progesterone receptor expression in patients with luminal B HER2-negative breast cancer. Chansub Park, Kyeongmee Park, +8 authors, Geumhee Gwak. less World J Surg Oncol, 2016 Sep 14; 14(1). PMID: 27619909 Free PMC article.
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MicroRNA-137 Inhibits Cancer Progression by Targeting Del-1 in Triple-Negative Breast Cancer Cells. Soo Jung Lee, Jae-Hwan Jeong, +6 authors, Yee Soo Chae. less Int J Mol Sci, 2019 Dec 11; 20(24). PMID: 31817673 Free PMC article.
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Axillary Lymph Node Dissection Does Not Improve Post-mastectomy Overall or Disease-Free Survival among Breast Cancer Patients with 1-3 Positive Nodes. Ji Hyeon Joo, Su Ssan Kim, +7 authors, Beom Seok Ko. less Cancer Res Treat, 2018 Oct 17; 51(3). PMID: 30322228 Free PMC article.
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Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients. Marcus Bauer, Eva Johanna Kantelhardt, +15 authors, Martina Vetter. less Oncotarget, 2019 Apr 09; 10(20). PMID: 30956778 Free PMC article.
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Development of a predictive model utilizing the neutrophil to lymphocyte ratio to predict neoadjuvant chemotherapy efficacy in early breast cancer patients. Jiujun Zhu, Dechuang Jiao, +4 authors, Zhenzhen Liu. less Sci Rep, 2021 Jan 16; 11(1). PMID: 33446717 Free PMC article.
HER2-Positive Breast Cancer Patients with Pre-Treatment Axillary Involvement or Postmenopausal Status Benefit from Neoadjuvant Rather than Adjuvant Chemotherapy Plus Trastuzumab Regimens. Enora Laas, Arnaud Bresset, +8 authors, Anne-Sophie Hamy. less Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33498405 Free PMC article.

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