Journal Article
. 2009 Jun; 4:19.
doi: 10.1186/1746-1596-4-19.

Mobile cell-phones (M-phones) in telemicroscopy: increasing connectivity of isolated laboratories

Livia Bellina 1 Eduardo Missoni  
Affiliations
  • PMID: 19545373
  •     2 References
  •     31 citations

Abstract

Background: The development of modern information telecommunication (ITC) technology and its use in telemedicine plays an increasingly important role in facilitating access to some diagnostic services even to people living in the most remote areas. However, physical and economical constraints in the access to broad band data-transmission network, still represent a considerable obstacle to the transmission of images for the purpose of tele-pathology.

Methods: Indifferently using m-phones of different brands, and a variety of microscopic preparations, images were taken without the use of any adaptor simply approaching the lens of the mobile cell phone camera to the ocular of common optical microscopes, and subsequently sent via Multimedia Messaging Services (MMS) to distant reference centres for tele-diagnosis. Access to MMS service was reviewed with specific reference to the African information communication technology (ICT) market.

Results: Images of any pathologic preparation could be captured and sent over the mobile phone with an MMS, without being limited by appropriate access to the internet for transmission (i.e. access to broad-band services). The quality of the image was not influenced by the brand or model of the mobile-phone used, but only by its digital resolution, with any resolution above 0.8 megapixel resulting in images sufficient for diagnosis.Access to MMS services is increasingly reaching remote disadvantaged areas. Current penetration of the service in Africa was mapped appearing already available in almost every country, with penetration index varying from 1.5% to 92.2%.

Conclusion: The use of otherwise already widely available technologies, without any need for adaptors or otherwise additional technology, could significantly increase opportunities and quality diagnostics while lowering costs and considerably increasing connectivity between most isolated laboratories and distant reference center.

Portable telepathology: methods and tools.
Luis Alfaro, Ma José Roca.
Diagn Pathol, 2008 Aug 05; 3 Suppl 1. PMID: 18673507    Free PMC article.
MMSPix - A multimedia service (MMS) medical images weblog.
Paul Fontelo, Fang Liu, +3 authors, Franciene Paalan-Vasquez.
AMIA Annu Symp Proc, 2008 Aug 13;. PMID: 18694056
Digital images and the future of digital pathology.
Liron Pantanowitz.
J Pathol Inform, 2010 Oct 06; 1. PMID: 20922032    Free PMC article.
Development of a point-of-care HIV/AIDS medication dosing support system using the Android mobile platform.
Rajani S Sadasivam, Vaibhav Gathibandhe, Murat M Tanik, James H Willig.
J Med Syst, 2010 Nov 09; 36(3). PMID: 21057886
Tackling HIV through robust diagnostics in the developing world: current status and future opportunities.
Darash Desai, Grace Wu, Muhammad H Zaman.
Lab Chip, 2010 Dec 03; 11(2). PMID: 21125097    Free PMC article.
Review.
Combined reflection and transmission microscope for telemedicine applications in field settings.
Gabriel Biener, Alon Greenbaum, +3 authors, Aydogan Ozcan.
Lab Chip, 2011 Jun 29; 11(16). PMID: 21709875    Free PMC article.
Data and image transfer using mobile phones to strengthen microscopy-based diagnostic services in low and middle income country laboratories.
Coosje J Tuijn, Bas J Hoefman, +2 authors, Nicolas Chevrollier.
PLoS One, 2011 Dec 24; 6(12). PMID: 22194829    Free PMC article.
Handheld computing in pathology.
Seung Park, Anil Parwani, Mahadev Satyanarayanan, Liron Pantanowitz.
J Pathol Inform, 2012 May 23; 3. PMID: 22616027    Free PMC article.
Nomenclatural benchmarking: the roles of digital typification and telemicroscopy.
Quentin Wheeler, Thierry Bourgoin, +6 authors, M Alma Solis.
Zookeys, 2012 Aug 04; (209). PMID: 22859888    Free PMC article.
The smartphone in medicine: a review of current and potential use among physicians and students.
Errol Ozdalga, Ark Ozdalga, Neera Ahuja.
J Med Internet Res, 2012 Sep 29; 14(5). PMID: 23017375    Free PMC article.
Highly Cited. Review.
Development of a teledermatopathology consultation system using virtual slides.
Ikunori Nakayama, Tsubasa Matsumura, +5 authors, Takashi Sawai.
Diagn Pathol, 2012 Dec 15; 7. PMID: 23237667    Free PMC article.
Mobile digital fluorescence microscopy for diagnosis of tuberculosis.
Asa Tapley, Neil Switz, +7 authors, Adithya Cattamanchi.
J Clin Microbiol, 2013 Apr 05; 51(6). PMID: 23554191    Free PMC article.
Cellphone-based devices for bioanalytical sciences.
Sandeep Kumar Vashist, Onur Mudanyali, +2 authors, Aydogan Ozcan.
Anal Bioanal Chem, 2013 Nov 30; 406(14). PMID: 24287630    Free PMC article.
Review.
Systematic review on what works, what does not work and why of implementation of mobile health (mHealth) projects in Africa.
Clara B Aranda-Jan, Neo Mohutsiwa-Dibe, Svetla Loukanova.
BMC Public Health, 2014 Feb 22; 14. PMID: 24555733    Free PMC article.
Highly Cited.
Quantitative imaging with a mobile phone microscope.
Arunan Skandarajah, Clay D Reber, Neil A Switz, Daniel A Fletcher.
PLoS One, 2014 May 16; 9(5). PMID: 24824072    Free PMC article.
Pocket pathologist: A mobile application for rapid diagnostic surgical pathology consultation.
Douglas J Hartman, Anil V Parwani, +10 authors, Liron Pantanowitz.
J Pathol Inform, 2014 May 21; 5(1). PMID: 24843822    Free PMC article.
Fabricating low cost and high performance elastomer lenses using hanging droplets.
W M Lee, A Upadhya, P J Reece, Tri Giang Phan.
Biomed Opt Express, 2014 May 31; 5(5). PMID: 24877020    Free PMC article.
A smartphone-based chip-scale microscope using ambient illumination.
Seung Ah Lee, Changhuei Yang.
Lab Chip, 2014 Jun 26; 14(16). PMID: 24964209    Free PMC article.
Smartphone adapters for digital photomicrography.
Somak Roy, Liron Pantanowitz, +6 authors, Douglas J Hartman.
J Pathol Inform, 2014 Sep 06; 5(1). PMID: 25191623    Free PMC article.
A comparative study of microscopic images captured by a box type digital camera versus a standard microscopic photography camera unit.
Nandini J Desai, B D Gupta, Pratik Narendrabhai Patel, Vani Santosh Joshi.
J Clin Diagn Res, 2014 Dec 06; 8(10). PMID: 25478350    Free PMC article.
Bubble wrap for optical trapping and cell culturing.
Craig McDonald, David McGloin.
Biomed Opt Express, 2015 Oct 28; 6(10). PMID: 26504627    Free PMC article.
Commercial Smartphone-Based Devices and Smart Applications for Personalized Healthcare Monitoring and Management.
Sandeep Kumar Vashist, E Marion Schneider, John H T Luong.
Diagnostics (Basel), 2014 Jan 01; 4(3). PMID: 26852680    Free PMC article.
Review.
Mobile phone imaging and cloud-based analysis for standardized malaria detection and reporting.
Thomas F Scherr, Sparsh Gupta, David W Wright, Frederick R Haselton.
Sci Rep, 2016 Jun 28; 6. PMID: 27345590    Free PMC article.
External quality assessment in resource-limited countries.
Jane Y Carter.
Biochem Med (Zagreb), 2017 Apr 11; 27(1). PMID: 28392732    Free PMC article.
Smartphone-Based Thermal Imaging: A New Modality for Tissue Temperature Measurement in Hand and Upper Extremity Surgeries.
Jue Cao, Kelly Currie, +3 authors, Kyros Ipaktchi.
Hand (N Y), 2017 Jun 14;. PMID: 28608716    Free PMC article.
Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings.
D J Shin, P Athamanolap, +6 authors, T H Wang.
Sci Rep, 2017 Jul 05; 7(1). PMID: 28674410    Free PMC article.
Development of a Simple Smartphone Adapter for Digital Photomicrography.
Himel Mondal, Shaikat Mondal, Debasish Das.
Indian Dermatol Online J, 2017 Dec 06; 8(6). PMID: 29204396    Free PMC article.
Long-Range Diagnosis of and Support for Skin Conditions in Field Settings.
Victoria Williams, Carrie Kovarik.
Trop Med Infect Dis, 2018 Oct 03; 3(3). PMID: 30274480    Free PMC article.
Smartphone-based clinical diagnostics: towards democratization of evidence-based health care.
I Hernández-Neuta, F Neumann, +5 authors, M Nilsson.
J Intern Med, 2018 Aug 07; 285(1). PMID: 30079527    Free PMC article.
Review.
Mobile phones in the orthopedic operating room: Microbial colonization and antimicrobial resistance.
Nada Qaisar Qureshi, Syed Hamza Mufarrih, +5 authors, Shahryar Noordin.
World J Orthop, 2020 Jun 02; 11(5). PMID: 32477902    Free PMC article.
Review.
Cell phone digital microscopy using an oil droplet.
Nicole Anna Szydlowski, Haoran Jing, Mohamed Alqashmi, Ying Samuel Hu.
Biomed Opt Express, 2020 Jun 06; 11(5). PMID: 32499926    Free PMC article.
Semi-permanent smartphone adapter for microscopes: Design demonstration and workflow testing using a slit-lamp biomicroscope.
Chieh-Hung Yen, Guo-Quan Wang, Tommy Y Lin, Chun-Hsiu Liu.
Taiwan J Ophthalmol, 2019 Jun 15; 9(2). PMID: 31198670    Free PMC article.
A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria.
Sthitodhi Ghosh, Kashish Aggarwal, +3 authors, Chong H Ahn.
Microsyst Nanoeng, 2020 Jan 27; 6. PMID: 34567620    Free PMC article.