Journal Article
. 2009 Aug; 31(2):296-308.
doi: 10.1016/j.immuni.2009.05.014.

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

Rachel L Rutishauser 1 Gislâine A Martins  Sergey Kalachikov  Anmol Chandele  Ian A Parish  Eric Meffre  Joshy Jacob  Kathryn Calame  Susan M Kaech  
  • PMID: 19664941
  •     62 References
  •     307 citations


During acute infections, a small population of effector CD8(+) T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional repressor Blimp-1 enhanced the formation of terminally differentiated CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection, and Blimp-1 deficiency promoted the acquisition of memory cell properties by effector cells. Blimp-1 expression was preferentially increased in terminally differentiated effector and "effector memory" (Tem) CD8(+) T cells, and gradually decayed after infection as central memory (Tcm) cells developed. Blimp-1-deficient effector CD8(+) T cells showed some reduction in effector molecule expression, but primarily developed into memory precursor cells that survived better and more rapidly acquired several Tcm cell attributes, including CD62L and IL-2 expression and enhanced proliferative responses. These results reveal a critical role for Blimp-1 in controlling terminal differentiation and suppressing memory cell developmental potential in effector CD8(+) T cells during viral infection.

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PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL.
Elena Cubedo, Michelle Maurin, +2 authors, Kenneth L Wright.
FEBS J, 2011 Jul 05; 278(17). PMID: 21722313    Free PMC article.
Origins of CD4(+) effector and central memory T cells.
Marion Pepper, Marc K Jenkins.
Nat Immunol, 2011 Jul 09; 12(6). PMID: 21739668    Free PMC article.
Highly Cited. Review.
T cell exhaustion.
E John Wherry.
Nat Immunol, 2011 Jul 09; 12(6). PMID: 21739672
Highly Cited. Review.
Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.
Makoto Kurachi, Junko Kurachi, +8 authors, Kouji Matsushima.
J Exp Med, 2011 Jul 27; 208(8). PMID: 21788406    Free PMC article.
IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo.
Fatema Z Chowdhury, Hilario J Ramos, +2 authors, J David Farrar.
Blood, 2011 Aug 13; 118(14). PMID: 21832277    Free PMC article.
CD8(+) T cells: foot soldiers of the immune system.
Nu Zhang, Michael J Bevan.
Immunity, 2011 Aug 27; 35(2). PMID: 21867926    Free PMC article.
Highly Cited. Review.
Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI.
Amaya I Wolf, Krystyna Mozdzanowska, +9 authors, Jan Erikson.
J Clin Invest, 2011 Sep 02; 121(10). PMID: 21881204    Free PMC article.
IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.
Qianting Yang, Gang Li, +7 authors, Binfeng Lu.
Eur J Immunol, 2011 Sep 03; 41(11). PMID: 21887788    Free PMC article.
A human memory T cell subset with stem cell-like properties.
Luca Gattinoni, Enrico Lugli, +14 authors, Nicholas P Restifo.
Nat Med, 2011 Sep 20; 17(10). PMID: 21926977    Free PMC article.
Highly Cited.
Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.
Nikhil S Joshi, Weiguo Cui, +3 authors, Susan M Kaech.
J Immunol, 2011 Sep 21; 187(8). PMID: 21930973    Free PMC article.
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Ben Youngblood, Kenneth J Oestreich, +9 authors, Rafi Ahmed.
Immunity, 2011 Sep 29; 35(3). PMID: 21943489    Free PMC article.
Highly Cited.
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development.
Iris Castro, Aixin Yu, Michael J Dee, Thomas R Malek.
J Immunol, 2011 Oct 11; 187(10). PMID: 21984699    Free PMC article.
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Joshua J Obar, Evan R Jellison, +4 authors, Leo Lefrançois.
J Immunol, 2011 Oct 12; 187(10). PMID: 21987662    Free PMC article.
Highly Cited.
Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells.
Yun Ji, Zoltan Pos, +12 authors, Luca Gattinoni.
Nat Immunol, 2011 Nov 08; 12(12). PMID: 22057288    Free PMC article.
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Cliff Y Yang, J Adam Best, +10 authors, Ananda W Goldrath.
Nat Immunol, 2011 Nov 08; 12(12). PMID: 22057289    Free PMC article.
Highly Cited.
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.
Weiguo Cui, Ying Liu, +2 authors, Susan M Kaech.
Immunity, 2011 Nov 29; 35(5). PMID: 22118527    Free PMC article.
Highly Cited.
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Andrea M Siegel, Jennifer Heimall, +8 authors, Joshua D Milner.
Immunity, 2011 Nov 29; 35(5). PMID: 22118528    Free PMC article.
Highly Cited.
Th17 cells are long lived and retain a stem cell-like molecular signature.
Pawel Muranski, Zachary A Borman, +19 authors, Nicholas P Restifo.
Immunity, 2011 Dec 20; 35(6). PMID: 22177921    Free PMC article.
Highly Cited.
CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells.
Mélissa Mathieu, Natacha Cotta-Grand, +3 authors, Nathalie Labrecque.
PLoS One, 2012 Feb 01; 7(1). PMID: 22291907    Free PMC article.
The role of interleukin-2 during homeostasis and activation of the immune system.
Onur Boyman, Jonathan Sprent.
Nat Rev Immunol, 2012 Feb 22; 12(3). PMID: 22343569
Highly Cited. Review.
T-cell biology in aging, with a focus on lung disease.
Naeun Lee, Min Sun Shin, Insoo Kang.
J Gerontol A Biol Sci Med Sci, 2012 Mar 08; 67(3). PMID: 22396471    Free PMC article.
CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help.
Han Dong, Nathan A Franklin, +3 authors, Timothy N J Bullock.
J Immunol, 2012 Mar 17; 188(8). PMID: 22422886    Free PMC article.
Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.
Shankar Subramanian Iyer, Gehong Cheng.
Crit Rev Immunol, 2012 Mar 21; 32(1). PMID: 22428854    Free PMC article.
Highly Cited. Review.
CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion.
Jarad J Wilson, Christopher D Pack, +7 authors, Aron E Lukacher.
J Immunol, 2012 Mar 27; 188(9). PMID: 22447978    Free PMC article.
Homeostatic maintenance of T cells and natural killer cells.
Onur Boyman, Carsten Krieg, Dirk Homann, Jonathan Sprent.
Cell Mol Life Sci, 2012 Mar 31; 69(10). PMID: 22460580    Free PMC article.
Signal integration by Akt regulates CD8 T cell effector and memory differentiation.
Eui Ho Kim, Jeremy A Sullivan, +4 authors, M Suresh.
J Immunol, 2012 Apr 03; 188(9). PMID: 22467649    Free PMC article.
Highly Cited.
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Scott M Krummey, Mandy L Ford.
Front Immunol, 2012 May 09; 3. PMID: 22566919    Free PMC article.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
Louise M D'Cruz, Kristin Camfield Lind, +2 authors, Ananda W Goldrath.
Eur J Immunol, 2012 May 16; 42(8). PMID: 22585759    Free PMC article.
Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.
Marc A J Morgan, Arne W Mould, +2 authors, Elizabeth K Bikoff.
Mol Cell Biol, 2012 Jun 27; 32(17). PMID: 22733990    Free PMC article.
The effects of TLR activation on T-cell development and differentiation.
Bo Jin, Tao Sun, +2 authors, Anthony E T Yeo.
Clin Dev Immunol, 2012 Jun 28; 2012. PMID: 22737174    Free PMC article.
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.
James E D Thaventhiran, Anja Hoffmann, +4 authors, Douglas T Fearon.
Proc Natl Acad Sci U S A, 2012 Jun 30; 109(33). PMID: 22745171    Free PMC article.
Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.
Yen-Yu Lin, Mary E Jones-Mason, +5 authors, Yuan Zhuang.
J Immunol, 2012 Jun 30; 189(3). PMID: 22745378    Free PMC article.
ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.
Hye Suk Yoon, Christopher D Scharer, +7 authors, Jeremy M Boss.
J Immunol, 2012 Aug 02; 189(5). PMID: 22851713    Free PMC article.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
M G de Goër de Herve, S Jaafoura, M Vallée, Y Taoufik.
Nat Commun, 2012 Aug 09; 3. PMID: 22871805    Free PMC article.
Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1.
Xinyuan Zhou, Hai-Hui Xue.
J Immunol, 2012 Aug 10; 189(6). PMID: 22875805    Free PMC article.
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation.
Klaas P J M van Gisbergen, Natasja A M Kragten, +5 authors, Rene A W van Lier.
Nat Immunol, 2012 Aug 14; 13(9). PMID: 22885984
Phenotype and function of protective, CD4-independent CD8 T cell memory.
Lindsay E Edwards, Catherine Haluszczak, Ross M Kedl.
Immunol Res, 2012 Sep 06; 55(1-3). PMID: 22948808    Free PMC article.
Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
Ryan D Michalek, Katie E Crump, +6 authors, Jason M Grayson.
J Virol, 2012 Oct 12; 86(24). PMID: 23055551    Free PMC article.
Transcriptional control of effector and memory CD8+ T cell differentiation.
Susan M Kaech, Weiguo Cui.
Nat Rev Immunol, 2012 Oct 20; 12(11). PMID: 23080391    Free PMC article.
Highly Cited. Review.
B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells.
Soofia Salehi, Rashmi Bankoti, +7 authors, Gislâine A Martins.
J Immunol, 2012 Nov 20; 189(12). PMID: 23162130    Free PMC article.
Anti-viral CD8 T cells and the cytokines that they love.
Maureen A Cox, Shannon M Kahan, Allan J Zajac.
Virology, 2012 Dec 12; 435(1). PMID: 23217625    Free PMC article.
Use it or lose it: establishment and persistence of T cell memory.
Katherine Kedzierska, Sophie A Valkenburg, +2 authors, Vanessa Venturi.
Front Immunol, 2012 Dec 12; 3. PMID: 23230439    Free PMC article.
Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection.
Brendan E Russ, Alice E Denton, +3 authors, Stephen J Turner.
Front Immunol, 2012 Dec 26; 3. PMID: 23267358    Free PMC article.
Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.
Jamie Knell, J Adam Best, +3 authors, Ananda W Goldrath.
J Immunol, 2013 Jan 18; 190(4). PMID: 23325888    Free PMC article.
Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation.
S Rameeza Allie, Weijun Zhang, +2 authors, Edward J Usherwood.
J Immunol, 2013 Jan 23; 190(5). PMID: 23338237    Free PMC article.
Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development.
Sema Kurtulus, Pulak Tripathi, David A Hildeman.
Front Immunol, 2013 Jan 25; 3. PMID: 23346085    Free PMC article.
Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
J Adam Best, David A Blair, +6 authors, Immunological Genome Project Consortium.
Nat Immunol, 2013 Feb 12; 14(4). PMID: 23396170    Free PMC article.
Highly Cited.
Disparate roles for STAT5 in primary and secondary CTL responses.
Diana M Mitchell, Matthew A Williams.
J Immunol, 2013 Feb 27; 190(7). PMID: 23440411    Free PMC article.
Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.
Pandelakis A Koni, Anna Bolduc, +9 authors, Michiko Shimoda.
J Immunol, 2013 Feb 27; 190(7). PMID: 23440421    Free PMC article.
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.
Youn Soo Choi, Jessica A Yang, +4 authors, Shane Crotty.
J Immunol, 2013 Mar 15; 190(8). PMID: 23487426    Free PMC article.
Highly Cited.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Marie Larsson, Esaki M Shankar, +5 authors, Adeeba Kamarulzaman.
Retrovirology, 2013 Mar 22; 10. PMID: 23514593    Free PMC article.
Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.
Frederick Masson, Martina Minnich, +7 authors, Gabrielle T Belz.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536629    Free PMC article.
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
Ana Villegas-Mendez, J Brian de Souza, +7 authors, Kevin N Couper.
PLoS Pathog, 2013 Apr 18; 9(4). PMID: 23593003    Free PMC article.
Differentiation of CD8 memory T cells depends on Foxo1.
Rodrigo Hess Michelini, Andrew L Doedens, Ananda W Goldrath, Stephen M Hedrick.
J Exp Med, 2013 May 29; 210(6). PMID: 23712431    Free PMC article.
Highly Cited.
FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.
Melba Marie Tejera, Eui Ho Kim, +2 authors, M Suresh.
J Immunol, 2013 Jun 05; 191(1). PMID: 23733882    Free PMC article.
Transcriptional regulation of effector and memory CD8+ T cell fates.
James E D Thaventhiran, Douglas T Fearon, Luca Gattinoni.
Curr Opin Immunol, 2013 Jun 12; 25(3). PMID: 23747000    Free PMC article.
CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis.
Korey R Demers, Morgan A Reuter, Michael R Betts.
Immunol Rev, 2013 Jun 19; 254(1). PMID: 23772621    Free PMC article.
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.
Rajarshi Bhadra, Dustin A Cobb, Imtiaz A Khan.
Infect Immun, 2013 Jul 03; 81(9). PMID: 23817617    Free PMC article.
Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.
Megan L Ives, Cindy S Ma, +24 authors, Elissa K Deenick.
J Allergy Clin Immunol, 2013 Jul 09; 132(2). PMID: 23830147    Free PMC article.
Nicotine inhibits memory CTL programming.
Zhifeng Sun, Kendra Smyth, +3 authors, Zhengguo Xiao.
PLoS One, 2013 Jul 12; 8(7). PMID: 23844169    Free PMC article.
Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.
Caitlin D Castro, Yuko Ohta, Helen Dooley, Martin F Flajnik.
Eur J Immunol, 2013 Jul 31; 43(11). PMID: 23897025    Free PMC article.
Environmental cues dictate the fate of individual CD8+ T cells responding to infection.
Courtney R Plumlee, Brian S Sheridan, Basak B Cicek, Leo Lefrançois.
Immunity, 2013 Aug 13; 39(2). PMID: 23932571    Free PMC article.
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Friederike Raczkowski, Josephine Ritter, +13 authors, Magdalena Huber.
Proc Natl Acad Sci U S A, 2013 Aug 28; 110(37). PMID: 23980171    Free PMC article.
Histone methyltransferase and histone methylation in inflammatory T-cell responses.
Shan He, Qing Tong, Dennis Keith Bishop, Yi Zhang.
Immunotherapy, 2013 Sep 04; 5(9). PMID: 23998733    Free PMC article.
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells.
Kevin Man, Maria Miasari, +9 authors, Axel Kallies.
Nat Immunol, 2013 Sep 24; 14(11). PMID: 24056747
Highly Cited.
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
Madhusudhanan Sukumar, Jie Liu, +13 authors, Luca Gattinoni.
J Clin Invest, 2013 Oct 05; 123(10). PMID: 24091329    Free PMC article.
Highly Cited.
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection.
Hyun Mu Shin, Varun Kapoor, +3 authors, Leslie J Berg.
Immunity, 2013 Oct 15; 39(4). PMID: 24120360    Free PMC article.
Lineage relationship of effector and memory T cells.
Nicholas P Restifo, Luca Gattinoni.
Curr Opin Immunol, 2013 Oct 24; 25(5). PMID: 24148236    Free PMC article.
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Payal B Watchmaker, Katharina Lahl, +9 authors, Eugene C Butcher.
Nat Immunol, 2013 Dec 03; 15(1). PMID: 24292363    Free PMC article.
Highly Cited.
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
Alexey Berezhnoy, Iris Castro, +2 authors, Eli Gilboa.
J Clin Invest, 2013 Dec 03; 124(1). PMID: 24292708    Free PMC article.
T cell responses: naive to memory and everything in between.
Nathan D Pennock, Jason T White, +3 authors, Ross M Kedl.
Adv Physiol Educ, 2013 Dec 03; 37(4). PMID: 24292902    Free PMC article.
A genome-wide regulatory network identifies key transcription factors for memory CD8⁺ T-cell development.
Guangan Hu, Jianzhu Chen.
Nat Commun, 2013 Dec 18; 4. PMID: 24335726    Free PMC article.
Identification and expression profiles of prdm1 in medaka Oryzias latipes.
Haobin Zhao, Xiaosha Zhang, +6 authors, Yaping Wang.
Mol Biol Rep, 2013 Dec 18; 41(2). PMID: 24343424
A replicative self-renewal model for long-lived plasma cells: questioning irreversible cell cycle exit.
Reuben M Tooze.
Front Immunol, 2014 Jan 05; 4. PMID: 24385976    Free PMC article.
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.
Janilyn Arsenio, Boyko Kakaradov, +3 authors, John T Chang.
Nat Immunol, 2014 Mar 04; 15(4). PMID: 24584088    Free PMC article.
Highly Cited.
The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.
Makoto Kurachi, R Anthony Barnitz, +9 authors, W Nicholas Haining.
Nat Immunol, 2014 Mar 04; 15(4). PMID: 24584090    Free PMC article.
Highly Cited.
Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection.
Peiyuan Lu, Benjamin A Youngblood, +4 authors, Jeremy M Boss.
J Exp Med, 2014 Mar 05; 211(3). PMID: 24590765    Free PMC article.
Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism.
Taeg S Kim, Stacey A Gorski, +2 authors, Thomas J Braciale.
Immunity, 2014 Mar 19; 40(3). PMID: 24631155    Free PMC article.
Highly Cited.
TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.
Weiguo Cui, Nikhil S Joshi, +3 authors, Susan M Kaech.
J Immunol, 2014 Mar 25; 192(9). PMID: 24659688    Free PMC article.
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
Rajarshi Bhadra, Magali M Moretto, +7 authors, Imtiaz A Khan.
J Clin Invest, 2014 Apr 26; 124(6). PMID: 24762437    Free PMC article.
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.
Michael M Opata, Robin Stephens.
Curr Immunol Rev, 2014 May 03; 9(3). PMID: 24790593    Free PMC article.
Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.
Ribhu Nayar, Elizabeth Schutten, +7 authors, Leslie J Berg.
J Immunol, 2014 May 20; 192(12). PMID: 24835398    Free PMC article.
Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal.
Julie Chaix, Simone A Nish, +4 authors, Steven L Reiner.
J Immunol, 2014 Jun 29; 193(3). PMID: 24973450    Free PMC article.
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.
Ian A Parish, Heather D Marshall, +10 authors, Susan M Kaech.
J Clin Invest, 2014 Jul 09; 124(8). PMID: 25003188    Free PMC article.
A clinically useful approach to enhance immunological memory and antitumor immunity.
Alex Berezhnoy, Anugraha Rajagopalan, Eli Gilboa.
Oncoimmunology, 2014 Jul 25; 3. PMID: 25057446    Free PMC article.
Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells.
Wataru Ise, Takeshi Inoue, +4 authors, Tomohiro Kurosaki.
Proc Natl Acad Sci U S A, 2014 Jul 30; 111(32). PMID: 25071203    Free PMC article.
Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Han-Yu Shih, Giuseppe Sciumè, +8 authors, John J O'Shea.
Immunol Rev, 2014 Aug 16; 261(1). PMID: 25123275    Free PMC article.
The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation.
Simon M Gray, Susan M Kaech, Matthew M Staron.
Immunol Rev, 2014 Aug 16; 261(1). PMID: 25123283    Free PMC article.
Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.
S Kurtulus, A Sholl, +5 authors, D A Hildeman.
Cell Death Differ, 2014 Aug 16; 22(1). PMID: 25124553    Free PMC article.
Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection.
Erik S Barton, Sujana Rajkarnikar, +2 authors, Jason M Grayson.
J Virol, 2014 Aug 22; 88(21). PMID: 25142586    Free PMC article.
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.
Runqiang Chen, Simon Bélanger, +9 authors, Matthew E Pipkin.
Immunity, 2014 Aug 26; 41(2). PMID: 25148027    Free PMC article.
A central role for Notch in effector CD8(+) T cell differentiation.
Ronald A Backer, Christina Helbig, +14 authors, Derk Amsen.
Nat Immunol, 2014 Oct 27; 15(12). PMID: 25344724    Free PMC article.
Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
Regina Lin, Ling Chen, +7 authors, Qi-Jing Li.
J Clin Invest, 2014 Oct 28; 124(12). PMID: 25347474    Free PMC article.
IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma.
Naeun Lee, Sungyong You, +13 authors, Insoo Kang.
Am J Respir Crit Care Med, 2014 Nov 13; 190(12). PMID: 25390970    Free PMC article.
Molecular regulation of effector and memory T cell differentiation.
John T Chang, E John Wherry, Ananda W Goldrath.
Nat Immunol, 2014 Nov 15; 15(12). PMID: 25396352    Free PMC article.
Highly Cited. Review.
MCL1 enhances the survival of CD8+ memory T Cells after viral infection.
Jingang Gui, Zhuting Hu, +7 authors, Edward J Usherwood.
J Virol, 2014 Dec 17; 89(4). PMID: 25505074    Free PMC article.
Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.
Katarzyna Kaczmarek Michaels, Malini Natarajan, +3 authors, Andrew J Henderson.
J Immunol, 2015 Feb 25; 194(7). PMID: 25710909    Free PMC article.
Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.
James M Billingsley, Premeela A Rajakumar, +10 authors, R Paul Johnson.
PLoS Pathog, 2015 Mar 15; 11(3). PMID: 25768938    Free PMC article.
Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape.
Joseph G Crompton, Manikandan Narayanan, +14 authors, Nicholas P Restifo.
Cell Mol Immunol, 2015 Apr 29; 13(4). PMID: 25914936    Free PMC article.
In vivo RNAi screens: concepts and applications.
Shane Crotty, Matthew E Pipkin.
Trends Immunol, 2015 May 06; 36(5). PMID: 25937561    Free PMC article.
CD8+ T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2.
Daniela Wojta-Stremayr, Alina Neunkirchner, +3 authors, Winfried F Pickl.
PLoS One, 2015 May 07; 10(5). PMID: 25946103    Free PMC article.
c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.
Maria Letizia Giardino Torchia, Ivana Munitic, +3 authors, Jonathan D Ashwell.
Eur J Immunol, 2015 Jun 23; 45(9). PMID: 26096449    Free PMC article.
Memory CD8 T cell transcriptional plasticity.
Ben Youngblood, J Scott Hale, Rafi Ahmed.
F1000Prime Rep, 2015 Jun 23; 7. PMID: 26097712    Free PMC article.
The Evolving Roles of Memory Immune Cells in Transplantation.
Wenhao Chen, Rafik M Ghobrial, Xian C Li.
Transplantation, 2015 Jun 24; 99(10). PMID: 26102615    Free PMC article.
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Brian J Laidlaw, Weiguo Cui, +8 authors, Susan M Kaech.
Nat Immunol, 2015 Jul 07; 16(8). PMID: 26147684    Free PMC article.
Highly Cited.
Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.
Arne W Mould, Marc A J Morgan, +2 authors, Elizabeth J Robertson.
PLoS Genet, 2015 Jul 15; 11(7). PMID: 26158850    Free PMC article.
Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity.
Katherine A Waugh, Sonia M Leach, Jill E Slansky.
Vaccines (Basel), 2015 Sep 24; 3(3). PMID: 26393659    Free PMC article.
Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype.
John J Erickson, Pengcheng Lu, +5 authors, John V Williams.
J Immunol, 2015 Sep 25; 195(9). PMID: 26401005    Free PMC article.
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
John P Ray, Matthew M Staron, +8 authors, Joe Craft.
Immunity, 2015 Sep 28; 43(4). PMID: 26410627    Free PMC article.
Highly Cited.
The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.
Shaniya H Khan, Matthew D Martin, +3 authors, Vladimir P Badovinac.
PLoS Pathog, 2015 Oct 03; 11(10). PMID: 26431533    Free PMC article.
Oct1 and OCA-B are selectively required for CD4 memory T cell function.
Arvind Shakya, Alon Goren, +8 authors, Dean Tantin.
J Exp Med, 2015 Oct 21; 212(12). PMID: 26481684    Free PMC article.
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.
Claudia X Dominguez, Robert A Amezquita, +4 authors, Susan M Kaech.
J Exp Med, 2015 Oct 28; 212(12). PMID: 26503446    Free PMC article.
Highly Cited.
IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus.
Michela Manni, Sanjay Gupta, +3 authors, Alessandra B Pernis.
PLoS One, 2015 Nov 07; 10(11). PMID: 26544714    Free PMC article.
Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells.
J Cao, X Zhang, +11 authors, J Zhang.
Cell Death Dis, 2015 Nov 20; 6. PMID: 26583325    Free PMC article.
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.
Magali M Moretto, Imtiaz A Khan.
J Immunol, 2015 Nov 26; 196(1). PMID: 26597007    Free PMC article.
Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.
Christopher A Klebanoff, Christopher D Scott, +24 authors, Nicholas P Restifo.
J Clin Invest, 2015 Dec 15; 126(1). PMID: 26657860    Free PMC article.
Highly Cited.
Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of rapamycin to alter murine effector CD8+ T-cell differentiation.
Bryan McQueen, Kelsey Trace, +2 authors, Amorette Barber.
Immunology, 2015 Dec 15; 147(3). PMID: 26661515    Free PMC article.
SLE-associated risk factors affect DC function.
Myoungsun Son, Sun Jung Kim, Betty Diamond.
Immunol Rev, 2015 Dec 20; 269(1). PMID: 26683148    Free PMC article.
Regulatory T cell memory.
Michael D Rosenblum, Sing Sing Way, Abul K Abbas.
Nat Rev Immunol, 2015 Dec 22; 16(2). PMID: 26688349    Free PMC article.
Highly Cited. Review.
Enhancing adoptive T cell immunotherapy with microRNA therapeutics.
Yun Ji, James D Hocker, Luca Gattinoni.
Semin Immunol, 2015 Dec 30; 28(1). PMID: 26710685    Free PMC article.
IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.
Ribhu Nayar, Elizabeth Schutten, +7 authors, Leslie J Berg.
PLoS One, 2015 Dec 30; 10(12). PMID: 26714260    Free PMC article.
Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses.
Danya Liu, Eileen M Burd, Craig M Coopersmith, Mandy L Ford.
J Immunol, 2016 Jan 06; 196(3). PMID: 26729800    Free PMC article.
The transcription factor BACH2 promotes tumor immunosuppression.
Rahul Roychoudhuri, Robert L Eil, +19 authors, Nicholas P Restifo.
J Clin Invest, 2016 Jan 06; 126(2). PMID: 26731475    Free PMC article.
IL-7 signalling represses Bcl-6 and the TFH gene program.
Paul W McDonald, Kaitlin A Read, +4 authors, Kenneth J Oestreich.
Nat Commun, 2016 Jan 09; 7. PMID: 26743592    Free PMC article.
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.
Mohammad Haque, Jianyong Song, +8 authors, Jianxun Song.
Open Biol, 2016 Jan 23; 6(1). PMID: 26791245    Free PMC article.
T Cell Vaccinology: Beyond the Reflection of Infectious Responses.
Nathan D Pennock, Justin D Kedl, Ross M Kedl.
Trends Immunol, 2016 Feb 03; 37(3). PMID: 26830540    Free PMC article.
Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection.
Eui Ho Kim, Brandon Neldner, +2 authors, M Suresh.
Virology, 2016 Feb 09; 490. PMID: 26855329    Free PMC article.
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
Scott M Krummey, Ryan J Martinez, +6 authors, Mandy L Ford.
J Immunol, 2016 Feb 13; 196(6). PMID: 26864034    Free PMC article.
Genetic and Epigenetic Regulation of PD-1 Expression.
Alexander P R Bally, James W Austin, Jeremy M Boss.
J Immunol, 2016 Mar 06; 196(6). PMID: 26945088    Free PMC article.
A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.
Annie Xin, Frederick Masson, +16 authors, Axel Kallies.
Nat Immunol, 2016 Mar 08; 17(4). PMID: 26950239    Free PMC article.
Highly Cited.
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.
Rahul Roychoudhuri, David Clever, +23 authors, Nicholas P Restifo.
Nat Immunol, 2016 May 10; 17(7). PMID: 27158840    Free PMC article.
Highly Cited.
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease.
John Attanasio, E John Wherry.
Immunity, 2016 May 19; 44(5). PMID: 27192569    Free PMC article.
Highly Cited. Review.
Effector, Memory, and Dysfunctional CD8(+) T Cell Fates in the Antitumor Immune Response.
John Reiser, Arnob Banerjee.
J Immunol Res, 2016 Jun 18; 2016. PMID: 27314056    Free PMC article.
IL-21 and T Cell Differentiation: Consider the Context.
Yuan Tian, Allan J Zajac.
Trends Immunol, 2016 Jul 09; 37(8). PMID: 27389961    Free PMC article.
Blimp-1-mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis.
SuJin Hwang, Dustin A Cobb, +2 authors, Imtiaz A Khan.
J Exp Med, 2016 Aug 03; 213(9). PMID: 27481131    Free PMC article.
CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
Yew Ann Leong, Yaping Chen, +34 authors, Di Yu.
Nat Immunol, 2016 Aug 04; 17(10). PMID: 27487330
Highly Cited.
T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function.
Martin J Richer, Mark L Lang, Noah S Butler.
J Immunol, 2016 Aug 09; 197(4). PMID: 27496973    Free PMC article.
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.
Yuki Kagoya, Munehide Nakatsugawa, +7 authors, Naoto Hirano.
J Clin Invest, 2016 Aug 23; 126(9). PMID: 27548527    Free PMC article.
Highly Cited.
IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.
Jean-Christophe Beltra, Sara Bourbonnais, +8 authors, Hélène Decaluwe.
Proc Natl Acad Sci U S A, 2016 Aug 31; 113(37). PMID: 27573835    Free PMC article.
NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses.
Emilia Pachulec, Vanessa Neitzke-Montinelli, João P B Viola.
Front Immunol, 2016 Oct 22; 7. PMID: 27766099    Free PMC article.
Convergence of Innate and Adaptive Immunity during Human Aging.
Branca I Pereira, Arne N Akbar.
Front Immunol, 2016 Nov 22; 7. PMID: 27867379    Free PMC article.
Protective immunity to liver-stage malaria.
Lauren E Holz, Daniel Fernandez-Ruiz, William R Heath.
Clin Transl Immunology, 2016 Nov 22; 5(10). PMID: 27867517    Free PMC article.
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.
Alexander P R Bally, Yan Tang, +4 authors, Jeremy M Boss.
J Immunol, 2016 Nov 30; 198(1). PMID: 27895178    Free PMC article.
Aptamer-Targeted Attenuation of IL-2 Signaling in CD8+ T Cells Enhances Antitumor Immunity.
Anugraha Rajagopalan, Alexey Berezhnoy, +2 authors, Eli Gilboa.
Mol Ther, 2017 Jan 28; 25(1). PMID: 28129128    Free PMC article.
CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile.
Tyler A Landrith, Suhas Sureshchandra, +5 authors, Emma H Wilson.
Front Immunol, 2017 Apr 21; 8. PMID: 28424687    Free PMC article.
Epigenomics of human CD8 T cell differentiation and aging.
David M Moskowitz, David W Zhang, +7 authors, Jörg J Goronzy.
Sci Immunol, 2017 Apr 26; 2(8). PMID: 28439570    Free PMC article.
Highly Cited.
The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function.
Sebastian Scheer, Colby Zaph.
Front Immunol, 2017 Apr 27; 8. PMID: 28443098    Free PMC article.
BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.
Behdad Afzali, Juha Grönholm, +34 authors, Arian D J Laurence.
Nat Immunol, 2017 May 23; 18(7). PMID: 28530713    Free PMC article.
The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development.
Mirte Post, Angelica Cuapio, +11 authors, Erhard Hofer.
Front Immunol, 2017 May 31; 8. PMID: 28555134    Free PMC article.
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Qiang Shan, Zhouhao Zeng, +13 authors, Hai-Hui Xue.
Nat Immunol, 2017 Jun 13; 18(8). PMID: 28604718    Free PMC article.
Highly Cited.
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia.
Liuluan Zhu, Yaxian Kong, +11 authors, Hong Zheng.
J Hematol Oncol, 2017 Jun 21; 10(1). PMID: 28629373    Free PMC article.
Protocol for improved resolution of plasma cell subpopulations by flow cytometry.
Joel R Wilmore, Derek D Jones, David Allman.
Eur J Immunol, 2017 Jun 28; 47(8). PMID: 28654161    Free PMC article.
Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells.
Hannah P Savage, Vanessa M Yenson, +3 authors, Nicole Baumgarth.
J Exp Med, 2017 Jul 13; 214(9). PMID: 28698287    Free PMC article.
Highly Cited.
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.
Natalie A Roberts, Brian D Adams, +5 authors, Valerie Horsley.
J Immunol, 2017 Jul 14; 199(4). PMID: 28701508    Free PMC article.
IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.
Amanda C Poholek, Dragana Jankovic, +10 authors, John J O'Shea.
Sci Immunol, 2017 Jul 18; 1(5). PMID: 28713870    Free PMC article.
New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function.
Shin-Huei Fu, Li-Tzu Yeh, +2 authors, Huey-Kang Sytwu.
J Biomed Sci, 2017 Jul 25; 24(1). PMID: 28732506    Free PMC article.
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Alexandria C Wells, Keith A Daniels, +7 authors, Leonid A Pobezinsky.
Elife, 2017 Jul 25; 6. PMID: 28737488    Free PMC article.
Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Hyun Mu Shin, Varun N Kapoor, +9 authors, Leslie J Berg.
PLoS Pathog, 2017 Aug 23; 13(8). PMID: 28827827    Free PMC article.
HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.
Pritesh Desai, Georges Abboud, +5 authors, Shahram Salek-Ardakani.
J Immunol, 2017 Sep 03; 199(8). PMID: 28864473    Free PMC article.
Differential regulation of Effector and Regulatory T cell function by Blimp1.
Rashmi Bankoti, Chihiro Ogawa, +10 authors, Gislâine A Martins.
Sci Rep, 2017 Sep 25; 7(1). PMID: 28935958    Free PMC article.
Constitutive expression of NF-κB inducing kinase in regulatory T cells impairs suppressive function and promotes instability and pro-inflammatory cytokine production.
Fanny Polesso, Minhazur Sarker, +2 authors, Susan E Murray.
Sci Rep, 2017 Nov 09; 7(1). PMID: 29116141    Free PMC article.
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation.
Shannon A Carty, Mercy Gohil, +7 authors, Martha S Jordan.
J Immunol, 2017 Nov 19; 200(1). PMID: 29150566    Free PMC article.
Effector CD8 T cells dedifferentiate into long-lived memory cells.
Ben Youngblood, J Scott Hale, +13 authors, Rafi Ahmed.
Nature, 2017 Dec 14; 552(7685). PMID: 29236683    Free PMC article.
Highly Cited.
ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.
Hongsheng Wang, Ines Gonzalez-Garcia, +15 authors, Herbert C Morse.
Sci Rep, 2017 Dec 21; 7(1). PMID: 29259245    Free PMC article.
A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.
Jing Zhou, Michael T Bethune, +6 authors, James R Heath.
PLoS One, 2018 Jan 24; 13(1). PMID: 29360859    Free PMC article.
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates.
Tianxia Guan, Claudia X Dominguez, +7 authors, Susan M Kaech.
J Exp Med, 2018 Feb 17; 215(4). PMID: 29449309    Free PMC article.
Highly Cited.
The Role of Mst1 in Lymphocyte Homeostasis and Function.
Jiali Cheng, Yukai Jing, +10 authors, Chaohong Liu.
Front Immunol, 2018 Feb 21; 9. PMID: 29459865    Free PMC article.
Transcriptional programming of tissue-resident memory CD8+ T cells.
J Justin Milner, Ananda W Goldrath.
Curr Opin Immunol, 2018 Apr 06; 51. PMID: 29621697    Free PMC article.
Highly Cited. Review.
Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs.
Christopher D Scharer, Benjamin G Barwick, +2 authors, Jeremy M Boss.
Nat Commun, 2018 Apr 29; 9(1). PMID: 29703886    Free PMC article.
Embryonic Fibroblasts Promote Antitumor Cytotoxic Effects of CD8+ T Cells.
Yingyu Qin, Jung Hoon Shin, Jeong-Ho Yoon, Se-Ho Park.
Front Immunol, 2018 May 01; 9. PMID: 29706956    Free PMC article.
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.
Nicolas Page, Bogna Klimek, +16 authors, Doron Merkler.
Immunity, 2018 May 17; 48(5). PMID: 29768177    Free PMC article.
PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
Anusara Daenthanasanmak, Yongxia Wu, +9 authors, Xue-Zhong Yu.
J Clin Invest, 2018 May 22; 128(7). PMID: 29781812    Free PMC article.
Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice.
Naoto Noguchi, Risa Nakamura, +4 authors, Yasunobu Yoshikai.
Infect Immun, 2018 May 31; 86(8). PMID: 29844233    Free PMC article.
TGF-β in T Cell Biology: Implications for Cancer Immunotherapy.
Amina Dahmani, Jean-Sébastien Delisle.
Cancers (Basel), 2018 Jun 13; 10(6). PMID: 29891791    Free PMC article.
Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors.
Yong Lu, Qiang Wang, +6 authors, Qing Yi.
Cancer Cell, 2018 Jun 13; 33(6). PMID: 29894691    Free PMC article.
Highly Cited.
The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen.
Mayura V Wagle, Julia M Marchingo, +3 authors, Ian A Parish.
Cell Rep, 2018 Jul 19; 24(3). PMID: 30021156    Free PMC article.
Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells.
Felix M Behr, Ammarina Chuwonpad, Regina Stark, Klaas P J M van Gisbergen.
Front Immunol, 2018 Aug 23; 9. PMID: 30131803    Free PMC article.
Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M.
Yi-An Ko, Yueh-Hsuan Chan, +5 authors, Kuo-I Lin.
Front Immunol, 2018 Aug 23; 9. PMID: 30131810    Free PMC article.
The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8+ Memory T Cells.
Elizabeth Olesin, Ribhu Nayar, Priya Saikumar-Lakshmi, Leslie J Berg.
Immunohorizons, 2018 Sep 29; 2(7). PMID: 30264035    Free PMC article.
Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune encephalomyelitis.
Saba I Aqel, Marissa C Granitto, +5 authors, Yuhong Yang.
J Neuroimmunol, 2018 Oct 27; 325. PMID: 30366205    Free PMC article.
Defining Memory CD8 T Cell.
Matthew D Martin, Vladimir P Badovinac.
Front Immunol, 2018 Dec 06; 9. PMID: 30515169    Free PMC article.
CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity.
Fuliang Chu, Haiyan S Li, +18 authors, Sattva S Neelapu.
Leukemia, 2019 Apr 28; 33(11). PMID: 31028278    Free PMC article.
Contribution of Resident Memory CD8+ T Cells to Protective Immunity Against Respiratory Syncytial Virus and Their Impact on Vaccine Design.
Angello Retamal-Díaz, Camila Covián, +4 authors, Alexis M Kalergis.
Pathogens, 2019 Sep 14; 8(3). PMID: 31514485    Free PMC article.
Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.
Mladen Jergović, Heather L Thompson, +2 authors, Janko Nikolich-Žugich.
Front Immunol, 2019 Oct 18; 10. PMID: 31620129    Free PMC article.
NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells.
Shubhranshu S Gupta, Robert Sharp, +4 authors, Min Chen.
Cell Rep, 2019 Nov 14; 29(7). PMID: 31722203    Free PMC article.
MicroRNA regulation of CD8+ T cell responses.
John D Gagnon, K Mark Ansel.
Noncoding RNA Investig, 2019 Dec 18; 3. PMID: 31844841    Free PMC article.
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.
Sara L Stone, Jessica N Peel, +18 authors, Frances E Lund.
Immunity, 2019 May 12; 50(5). PMID: 31076359    Free PMC article.
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision.
Zeyu Chen, Zhicheng Ji, +24 authors, E John Wherry.
Immunity, 2019 Oct 14; 51(5). PMID: 31606264    Free PMC article.
Highly Cited.
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act.
Vandana Kalia, Surojit Sarkar.
Front Immunol, 2019 Jan 09; 9. PMID: 30619342    Free PMC article.
The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok.
Thomas Ciucci, Melanie S Vacchio, +9 authors, Rémy Bosselut.
Immunity, 2019 Jan 15; 50(1). PMID: 30638736    Free PMC article.
Therapeutic Cancer Vaccines-T Cell Responses and Epigenetic Modulation.
Apriliana E R Kartikasari, Monica D Prakash, +4 authors, Magdalena Plebanski.
Front Immunol, 2019 Feb 12; 9. PMID: 30740111    Free PMC article.
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Garima Garg, Andreas Muschaweckh, +19 authors, Thomas Korn.
Cell Rep, 2019 Feb 14; 26(7). PMID: 30759395    Free PMC article.
Highly Cited.
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Deepali V Sawant, Hiroshi Yano, +16 authors, Dario A A Vignali.
Nat Immunol, 2019 Apr 03; 20(6). PMID: 30936494    Free PMC article.
Highly Cited.
miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate.
Yun Ji, Jessica Fioravanti, +19 authors, Luca Gattinoni.
Nat Commun, 2019 May 16; 10(1). PMID: 31089138    Free PMC article.
Remembering to remember: T cell memory maintenance and plasticity.
Kyla D Omilusik, Ananda W Goldrath.
Curr Opin Immunol, 2019 Jun 07; 58. PMID: 31170601    Free PMC article.
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections.
Hannah P Savage, Kathrin Kläsener, +3 authors, Nicole Baumgarth.
Elife, 2019 Aug 23; 8. PMID: 31433296    Free PMC article.
CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance.
Yuhong Chen, Mei Yu, +12 authors, Demin Wang.
Nat Commun, 2019 Sep 29; 10(1). PMID: 31562329    Free PMC article.
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Carla A Jaeger-Ruckstuhl, Magdalena Hinterbrandner, +11 authors, Adrian F Ochsenbein.
Nat Commun, 2020 Apr 04; 11(1). PMID: 32242021    Free PMC article.
Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs.
Felix M Behr, Natasja A M Kragten, +6 authors, Klaas P J M van Gisbergen.
Front Immunol, 2019 Mar 23; 10. PMID: 30899267    Free PMC article.
Blimp-1 Contributes to the Development and Function of Regulatory B Cells.
Ying-Hsiu Wang, Dong-Yan Tsai, +4 authors, Kuo-I Lin.
Front Immunol, 2019 Sep 03; 10. PMID: 31474988    Free PMC article.
Stability and flexibility in chromatin structure and transcription underlies memory CD8 T-cell differentiation.
Huitian Diao, Matthew Pipkin.
F1000Res, 2019 Aug 27; 8. PMID: 31448086    Free PMC article.
Programmed T cell differentiation: Implications for transplantation.
Rebecca L Crepeau, Mandy L Ford.
Cell Immunol, 2020 Apr 06; 351. PMID: 32247511    Free PMC article.
Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion.
Mumtaz Y Balkhi.
Oncoimmunology, 2020 May 05; 9(1). PMID: 32363117    Free PMC article.
EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo.
Lin Xia, Zao-Zao Zheng, +5 authors, Wen Liu.
Clin Transl Immunology, 2020 May 07; 9(5). PMID: 32373345    Free PMC article.
The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches.
Hanbyeul Choi, Heonju Song, Yong Woo Jung.
Immune Netw, 2020 Jul 14; 20(3). PMID: 32655968    Free PMC article.
Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
Rong En Tay, Olamide Olawoyin, +9 authors, Kai W Wucherpfennig.
J Exp Med, 2020 May 07; 217(7). PMID: 32374402    Free PMC article.
Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung.
Kun He, Angela Hettinga, +5 authors, Amanda C Poholek.
J Exp Med, 2020 May 14; 217(7). PMID: 32399548    Free PMC article.
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.
Santosha A Vardhana, Madeline A Hwee, +10 authors, Craig B Thompson.
Nat Immunol, 2020 Jul 15; 21(9). PMID: 32661364    Free PMC article.
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
Olivia Cypris, Monika Eipel, +11 authors, Wolfgang Wagner.
Clin Epigenetics, 2020 Aug 21; 12(1). PMID: 32819411    Free PMC article.
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.
Jinyong Choi, Huitian Diao, +7 authors, Shane Crotty.
Nat Immunol, 2020 Jun 24; 21(7). PMID: 32572238    Free PMC article.
Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3.
Livia Odagiu, Salix Boulet, +3 authors, Nathalie Labrecque.
Proc Natl Acad Sci U S A, 2020 Sep 12; 117(39). PMID: 32913051    Free PMC article.
The Transcription Factor TCF1 in T Cell Differentiation and Aging.
Chulwoo Kim, Jun Jin, Cornelia M Weyand, Jörg J Goronzy.
Int J Mol Sci, 2020 Sep 10; 21(18). PMID: 32899486    Free PMC article.
IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection.
Heather M Ren, Aron E Lukacher.
Int J Mol Sci, 2020 Sep 26; 21(18). PMID: 32971931    Free PMC article.
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.
J Justin Milner, Hongtuyet Nguyen, +8 authors, Ananda W Goldrath.
Proc Natl Acad Sci U S A, 2020 Sep 27; 117(41). PMID: 32978300    Free PMC article.
Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion.
Daniel J Verdon, Matthias Mulazzani, Misty R Jenkins.
Int J Mol Sci, 2020 Oct 09; 21(19). PMID: 33027962    Free PMC article.
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Jessica Wagner, Elizabeth Wickman, Christopher DeRenzo, Stephen Gottschalk.
Mol Ther, 2020 Sep 27; 28(11). PMID: 32979309    Free PMC article.
Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation.
Ricardo A León-Letelier, Daniel I Castro-Medina, +8 authors, Laura C Bonifaz.
Front Immunol, 2020 Nov 27; 11. PMID: 33240271    Free PMC article.
Stemness of T cells and the hematopoietic stem cells: fate, memory, niche, cytokines.
Francesca B Aiello, Laura Graciotti, +2 authors, Scott K Durum.
Cytokine Growth Factor Rev, 2013 Nov 16; 24(6). PMID: 24231048    Free PMC article.
Differential effects of IL-15 on the generation, maintenance and cytotoxic potential of adaptive cellular responses induced by DNA vaccination.
Jinyao Li, Antonio Valentin, +5 authors, George N Pavlakis.
Vaccine, 2015 Jan 07; 33(9). PMID: 25559187    Free PMC article.
Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease.
Isabel Ulmert, Luís Henriques-Oliveira, Carlos-Filipe Pereira, Katharina Lahl.
Immunology, 2020 Aug 18; 161(4). PMID: 32799350    Free PMC article.
MyD88/CD40 signaling retains CAR T cells in a less differentiated state.
Brooke Prinzing, Patrick Schreiner, +3 authors, Stephen Gottschalk.
JCI Insight, 2020 Nov 06; 5(21). PMID: 33148882    Free PMC article.
Memory CD8+ T cell responses to cancer.
Jichang Han, Nikhil Khatwani, +2 authors, Christina V Angeles.
Semin Immunol, 2020 Dec 05; 49. PMID: 33272898    Free PMC article.
Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral Infection.
Masao Hashimoto, Se Jin Im, Koichi Araki, Rafi Ahmed.
Cold Spring Harb Perspect Biol, 2017 Nov 05; 11(1). PMID: 29101105    Free PMC article.
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
J Justin Milner, Clara Toma, +12 authors, Ananda W Goldrath.
Immunity, 2020 May 21; 52(5). PMID: 32433949    Free PMC article.
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.
Dapeng Wang, Huitian Diao, +7 authors, Matthew E Pipkin.
Immunity, 2018 Apr 19; 48(4). PMID: 29669249    Free PMC article.
Highly Cited.
The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8+ T cells during viral infection.
Hemant Jaiswal, Thomas Ciucci, +5 authors, Ulrich Siebenlist.
PLoS Pathog, 2021 Jan 29; 17(1). PMID: 33508001    Free PMC article.
The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes.
Matthew Clark, Charles J Kroger, Qi Ke, Roland M Tisch.
Front Immunol, 2021 Feb 20; 11. PMID: 33603744    Free PMC article.
T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies.
Valérie Janelle, Jean-Sébastien Delisle.
Cancers (Basel), 2021 Feb 07; 13(4). PMID: 33546277    Free PMC article.
Id3 and Bcl6 Promote the Development of Long-Term Immune Memory Induced by Tuberculosis Subunit Vaccine.
Jiangyuan Han, Yanlin Ma, +8 authors, Bingdong Zhu.
Vaccines (Basel), 2021 Feb 11; 9(2). PMID: 33562631    Free PMC article.
Transcriptional and epigenetic regulation of PD-1 expression.
Zengde Chi, Yan Lu, +2 authors, Peiyuan Lu.
Cell Mol Life Sci, 2021 Mar 20; 78(7). PMID: 33738533
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.
H Kay Chung, Bryan McDonald, Susan M Kaech.
J Exp Med, 2021 Mar 24; 218(4). PMID: 33755719    Free PMC article.
IFNAR1 signaling in NK cells promotes persistent virus infection.
Zhe Huang, Seung Goo Kang, +7 authors, Changchun Xiao.
Sci Adv, 2021 Mar 28; 7(13). PMID: 33771858    Free PMC article.
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Evan W Weber, Kevin R Parker, +23 authors, Crystal L Mackall.
Science, 2021 Apr 03; 372(6537). PMID: 33795428    Free PMC article.
Conversations that count: Cellular interactions that drive T cell fate.
Brigette C Duckworth, Joanna R Groom.
Immunol Rev, 2021 Feb 16; 300(1). PMID: 33586207    Free PMC article.
Cellular networks controlling T cell persistence in adoptive cell therapy.
Jack D Chan, Junyun Lai, +3 authors, Phillip K Darcy.
Nat Rev Immunol, 2021 Apr 22; 21(12). PMID: 33879873
PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA).
Burcu Akman, Xiaozhou Hu, +4 authors, Can Küçük.
J Leukoc Biol, 2020 Nov 05; 109(5). PMID: 33145806    Free PMC article.
B lymphocyte-induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation.
Luciana Benevides, Renata Sesti Costa, +7 authors, João Santana Silva.
J Allergy Clin Immunol, 2018 Aug 11; 143(3). PMID: 30096391    Free PMC article.
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Hongling Huang, Peipei Zhou, +13 authors, Hongbo Chi.
Cell, 2021 Feb 27; 184(5). PMID: 33636132    Free PMC article.
Optimal evolutionary decision-making to store immune memory.
Oskar H Schnaack, Armita Nourmohammad.
Elife, 2021 Apr 29; 10. PMID: 33908347    Free PMC article.
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection.
J Justin Milner, Clara Toma, +20 authors, Ananda W Goldrath.
J Exp Med, 2021 May 27; 218(8). PMID: 34037670    Free PMC article.
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage.
Jonathan B Johnnidis, Yuki Muroyama, +25 authors, E John Wherry.
Sci Immunol, 2021 Jan 17; 6(55). PMID: 33452106    Free PMC article.
A statistical framework for differential pseudotime analysis with multiple single-cell RNA-seq samples.
Wenpin Hou, Zhicheng Ji, +3 authors, Hongkai Ji.
bioRxiv, 2021 Jul 21;. PMID: 34282418    Free PMC article.
Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8+ T Cells.
Yao Chen, Jian Shen, +2 authors, Weiguo Cui.
Cells, 2021 Aug 28; 10(8). PMID: 34440912    Free PMC article.
CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach.
Marko Šustić, Maja Cokarić Brdovčak, Astrid Krmpotić, Stipan Jonjić.
Life (Basel), 2021 Oct 24; 11(10). PMID: 34685468    Free PMC article.
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.
Daniel Hirschhorn, Allison Betof Warner, +11 authors, Jedd D Wolchok.
JCI Insight, 2021 Oct 23; 6(20). PMID: 34676831    Free PMC article.
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response.
Kelli A Connolly, Manik Kuchroo, +19 authors, Nikhil S Joshi.
Sci Immunol, 2021 Oct 02; 6(64). PMID: 34597124    Free PMC article.
Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines.
Trine Sundebo Meldgaard, Fabiola Blengio, +7 authors, Sylvie Bertholet.
Front Immunol, 2021 Nov 16; 12. PMID: 34777370    Free PMC article.
Enhancing T Cell Chemotaxis and Infiltration in Glioblastoma.
Kirit Singh, Kelly M Hotchkiss, +4 authors, John H Sampson.
Cancers (Basel), 2021 Nov 14; 13(21). PMID: 34771532    Free PMC article.
Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells.
Thomas Ciucci, Melanie S Vacchio, +5 authors, Rémy Bosselut.
J Exp Med, 2021 Nov 19; 219(1). PMID: 34792530    Free PMC article.
DNA Methylation and Immune Memory Response.
Nathalia Noschang Mittelstaedt, André Luiz Becker, +3 authors, Ana Paula Duarte de Souza.
Cells, 2021 Nov 28; 10(11). PMID: 34831166    Free PMC article.
The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development.
Wilson L Mandala, Visopo Harawa, Fraction Dzinjalamala, Dumizulu Tembo.
Mol Biochem Parasitol, 2021 Oct 20; 246. PMID: 34666102    Free PMC article.
A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response.
Sarah L Cook, Marissa C Franke, Evelyn P Sievert, Roger Sciammas.
Trends Immunol, 2020 May 30; 41(7). PMID: 32467029    Free PMC article.
Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development.
Kelvin Mokaya Abuga, William Jones-Warner, Julius Clemence R Hafalla.
Parasite Immunol, 2020 Sep 28; 43(2). PMID: 32981095    Free PMC article.
Conserved and Unique Functions of Blimp1 in Immune Cells.
Samantha Nadeau, Gislâine A Martins.
Front Immunol, 2022 Feb 15; 12. PMID: 35154079    Free PMC article.
DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Anjun Jiao, Chenming Sun, +11 authors, Baojun Zhang.
Sci Adv, 2022 Feb 10; 8(6). PMID: 35138904    Free PMC article.
STAT3 Role in T-Cell Memory Formation.
Yaroslav Kaminskiy, Jan Joseph Melenhorst.
Int J Mol Sci, 2022 Mar 11; 23(5). PMID: 35270020    Free PMC article.