Review
. 2009 Aug; 20(11):1240-8.
doi: 10.1089/hum.2009.146.

T cell receptor gene therapy for cancer

Thomas M Schmitt 1 Gunnar B Ragnarsson  Philip D Greenberg  
Affiliations
  • PMID: 19702439
  •     72 References
  •     43 citations

Abstract

T cell-based adoptive immunotherapy has been shown to be a promising treatment for various types of cancer. However, adoptive T cell therapy currently requires the custom isolation and characterization of tumor-specific T cells from each patient-a process that can be not only difficult and time-consuming but also often fails to yield high-avidity T cells, which together have limited the broad application of this approach as a clinical treatment. Employing T cell receptor (TCR) gene therapy as a component of adoptive T cell therapy strategies can overcome many of these obstacles, allowing autologous T cells with a defined specificity to be generated in a much shorter time period. Initial studies using this approach have been hampered by a number of technical difficulties resulting in low TCR expression and acquisition of potentially problematic specificities due to mispairing of introduced TCR chains with endogenous TCR chains. The last several years have seen substantial progress in our understanding of the multiple facets of TCR gene therapy that will have to be properly orchestrated for this strategy to succeed. Here we outline the challenges of TCR gene therapy and the advances that have been made toward realizing the promise of this approach.

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T-Cell Receptor-Based Immunotherapy for Hematologic Malignancies.
Melinda A Biernacki, Michelle Brault, Marie Bleakley.
Cancer J, 2019 May 29; 25(3). PMID: 31135525    Free PMC article.
Review.
Protein phase separation: A novel therapy for cancer?
Wei Wang, Yingqian Chen, +7 authors, Qiaojun He.
Br J Pharmacol, 2020 Aug 28; 177(22). PMID: 32851637    Free PMC article.
Review.
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
Naixue Yang, Fansen Ji, +4 authors, Xun Lan.
NPJ Precis Oncol, 2021 May 09; 5(1). PMID: 33963274    Free PMC article.
Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies.
Mengrui Liu, Blanca López de Juan Abad, Ke Cheng.
Adv Drug Deliv Rev, 2021 Apr 09; 173. PMID: 33831476    Free PMC article.
Review.
Finding Solutions for Fibrosis: Understanding the Innate Mechanisms Used by Super-Regenerator Vertebrates to Combat Scarring.
Fallon Durant, Jessica L Whited.
Adv Sci (Weinh), 2021 May 26; 8(15). PMID: 34032013    Free PMC article.
Review.
An efficient method to identify virus-specific TCRs for TCR-T cell immunotherapy against virus-associated malignancies.
Lei Chen, Lianhua Dong, +4 authors, Mingjun Wang.
BMC Immunol, 2021 Sep 30; 22(1). PMID: 34583647    Free PMC article.
Emerging Strategies in TCR-Engineered T Cells.
Fang Wei, Xiao-Xia Cheng, John Zhao Xue, Shao-An Xue.
Front Immunol, 2022 Apr 19; 13. PMID: 35432319    Free PMC article.
Review.