Review
. 2009 Sep; 46(1-3):216-26.
doi: 10.1007/s12026-009-8119-4.

Enhancement of anti-tumor immunity by photodynamic therapy

Sandra O Gollnick 1 Craig M Brackett  
Affiliations
  • PMID: 19763892
  •     89 References
  •     50 citations

Abstract

Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.

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Malgorzata Wachowska, Joanna Stachura, +8 authors, Angelika Muchowicz.
Cancer Immunol Immunother, 2020 Feb 29; 69(6). PMID: 32107566    Free PMC article.
Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion.
Sander Bekeschus, Ramona Clemen, +3 authors, Anke Schmidt.
Adv Sci (Weinh), 2020 May 23; 7(10). PMID: 32440479    Free PMC article.
Photodynamic Therapy and Immunity: An Update.
Riddhi Falk-Mahapatra, Sandra O Gollnick.
Photochem Photobiol, 2020 Mar 05; 96(3). PMID: 32128821    Free PMC article.
Review.
A preclinical model to investigate the role of surgically-induced inflammation in tumor responses to intraoperative photodynamic therapy.
Richard W Davis, Emmanouil Papasavvas, +10 authors, Theresa M Busch.
Lasers Surg Med, 2018 May 26; 50(5). PMID: 29799130    Free PMC article.
Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy.
Richard W Davis, Emma Snyder, +6 authors, Theresa M Busch.
Photochem Photobiol, 2018 Oct 26; 95(1). PMID: 30357853    Free PMC article.
Effects of ALA-PDT on the Healing of Mouse Skin Wounds Infected With Pseudomonas aeruginosa and Its Related Mechanisms.
Tao Yang, Yang Tan, +6 authors, Xia Lei.
Front Cell Dev Biol, 2020 Dec 22; 8. PMID: 33344449    Free PMC article.
Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment.
Waleska K Martins, Renata Belotto, +6 authors, Tayana M Tsubone.
Front Oncol, 2021 Feb 09; 10. PMID: 33552982    Free PMC article.
Review.
Survival Outcomes with Photodynamic Therapy, Chemotherapy and Radiation in Patients with Stage III or Stage IV Non-Small Cell Lung Cancer.
Sumedha Chhatre, Anil Vachani, Ron R Allison, Ravishankar Jayadevappa.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671863    Free PMC article.
Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal-organic photodynamic therapy.
Deborah A Smithen, Susan Monro, +6 authors, Sherri A McFarland.
Chem Sci, 2021 Mar 20; 11(44). PMID: 33738086    Free PMC article.
Tailoring photosensitive ROS for advanced photodynamic therapy.
Duc Loc Sai, Jieun Lee, Duc Long Nguyen, Young-Pil Kim.
Exp Mol Med, 2021 Apr 10; 53(4). PMID: 33833374    Free PMC article.
Review.
Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.
Liubov M Lifshits, John A Roque Iii, +9 authors, Sherri A McFarland.
Chem Sci, 2021 May 13; 11(43). PMID: 33976756    Free PMC article.
Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer.
Nelson A M Pereira, Mafalda Laranjo, +9 authors, Teresa M V D Pinho E Melo.
RSC Med Chem, 2021 May 29; 12(4). PMID: 34046633    Free PMC article.
Intratumoral Photosensitizer Delivery and Photodynamic Therapy.
Chen-Hua Ma, Jeffrey Yang, Jenna L Mueller, Huang-Chiao Huang.
Nano Life, 2021 Sep 07; 11(2). PMID: 34484435    Free PMC article.
Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.
Prathyusha Konda, John A Roque Iii, +6 authors, Shashi Gujar.
Am J Cancer Res, 2022 Feb 11; 12(1). PMID: 35141014    Free PMC article.
Nanoparticle Phototherapy in the Era of Cancer Immunotherapy.
Shiyi Zhou, Dandan Li, Chaebin Lee, Jin Xie.
Trends Chem, 2020 Dec 01; 2(12). PMID: 35178514    Free PMC article.
Assembled small organic molecules for photodynamic therapy and photothermal therapy.
Lixin Sun, Jian Wang, +6 authors, Jianzhuang Jiang.
RSC Adv, 2022 Apr 16; 11(17). PMID: 35423511    Free PMC article.
Review.
Strategies for Improving Photodynamic Therapy Through Pharmacological Modulation of the Immediate Early Stress Response.
Daniel J de Klerk, Mark J de Keijzer, +6 authors, Photodynamic Therapy Study Group.
Methods Mol Biol, 2022 May 04; 2451. PMID: 35505025
Review.
Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.
John A Roque Iii, Houston D Cole, +8 authors, Sherri A McFarland.
J Am Chem Soc, 2022 Apr 29; 144(18). PMID: 35482975    Free PMC article.
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation.
Mafalda Laranjo, Nelson A M Pereira, +10 authors, Teresa M V D Pinho E Melo.
Front Chem, 2022 May 17; 10. PMID: 35572112    Free PMC article.