Review
. 2009 Nov;1805(1).
doi: 10.1016/j.bbcan.2009.11.002.

Tumor heterogeneity: causes and consequences

Andriy Marusyk 1 Kornelia Polyak  
Affiliations
  • PMID: 19931353
  •     145 References
  •     535 citations

Abstract

With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of clinical diagnosis, the majority of human tumors display startling heterogeneity in many morphological and physiological features, such as expression of cell surface receptors, proliferative and angiogenic potential. To a substantial extent, this heterogeneity might be attributed to morphological and epigenetic plasticity, but there is also strong evidence for the co-existence of genetically divergent tumor cell clones within tumors. In this perspective, we summarize the sources of intra-tumor phenotypic heterogeneity with emphasis on genetic heterogeneity. We review experimental evidence for the existence of both intra-tumor clonal heterogeneity as well as frequent evolutionary divergence between primary tumors and metastatic outgrowths. Furthermore, we discuss potential biological and clinical implications of intra-tumor clonal heterogeneity.

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Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression.
L Holmgren, M S O'Reilly, J Folkman.
Nat Med, 1995 Feb 01; 1(2). PMID: 7585012
Highly Cited.
Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma.
S W Coons, P C Johnson, J R Shapiro.
Cancer Res, 1995 Apr 01; 55(7). PMID: 7882367
Immunohistochemical assessment of individual tumor cells in lymph nodes of patients with non-small-cell lung cancer.
B Passlick, J R Izbicki, +6 authors, K Pantel.
J Clin Oncol, 1994 Sep 01; 12(9). PMID: 8083707
Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat.
R Korona, C H Nakatsu, L J Forney, R E Lenski.
Proc Natl Acad Sci U S A, 1994 Sep 13; 91(19). PMID: 8090765    Free PMC article.
Unknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients.
J L Abbruzzese, M C Abbruzzese, +3 authors, P Frost.
J Clin Oncol, 1994 Jun 01; 12(6). PMID: 8201389
Heterogeneity of prostate cancer in radical prostatectomy specimens.
M Aihara, T M Wheeler, M Ohori, P T Scardino.
Urology, 1994 Jan 01; 43(1). PMID: 8284886
Cancer cell societies and tumor progression.
G H Heppner.
Stem Cells, 1993 May 01; 11(3). PMID: 8318906
Review.
Heterogeneity of chromosome 17 and erbB-2 gene copy number in primary and metastatic bladder cancer.
G Sauter, H Moch, +2 authors, F M Waldman.
Cytometry, 1995 Sep 01; 21(1). PMID: 8529469
Genetic divergence in the clonal evolution of breast cancer.
H Fujii, C Marsh, +2 authors, E Gabrielson.
Cancer Res, 1996 Apr 01; 56(7). PMID: 8603391
Karyotypic comparisons of multiple tumorous and macroscopically normal surrounding tissue samples from patients with breast cancer.
M R Teixeira, N Pandis, +2 authors, S Heim.
Cancer Res, 1996 Feb 15; 56(4). PMID: 8631024
Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.
M R Novelli, J A Williamson, +5 authors, N A Wright.
Science, 1996 May 24; 272(5265). PMID: 8638166
Genetic progression model for head and neck cancer: implications for field cancerization.
J Califano, P van der Riet, +8 authors, D Sidransky.
Cancer Res, 1996 Jun 01; 56(11). PMID: 8653682
Highly Cited.
Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.
W Giaretti, R Monaco, +3 authors, E Geido.
Am J Pathol, 1996 Jul 01; 149(1). PMID: 8686748    Free PMC article.
Histological grade heterogeneity in multifocal prostate cancer. Biological and clinical implications.
E T Ruijter, C A van de Kaa, +2 authors, D J Ruiter.
J Pathol, 1996 Nov 01; 180(3). PMID: 8958808
Modelling the consequences of interactions between tumour cells.
I P Tomlinson, W F Bodmer.
Br J Cancer, 1997 Jan 01; 75(2). PMID: 9010019    Free PMC article.
Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer.
T Kuukasjärvi, R Karhu, +7 authors, J Isola.
Cancer Res, 1997 Apr 15; 57(8). PMID: 9108466
Highly Cited.
Game-theory models of interactions between tumour cells.
I P Tomlinson.
Eur J Cancer, 1997 Aug 01; 33(9). PMID: 9337695
Precise microdissection of human prostate cancers reveals genotypic heterogeneity.
C A Macintosh, M Stower, N Reid, N J Maitland.
Cancer Res, 1998 Jan 13; 58(1). PMID: 9426051
Spontaneous regression of localized neuroblastoma detected by mass screening.
K Yamamoto, R Hanada, +7 authors, Y Hayashi.
J Clin Oncol, 1998 Apr 29; 16(4). PMID: 9552024
The clonal evolution of tumor cell populations.
P C Nowell.
Science, 1976 Oct 01; 194(4260). PMID: 959840
Highly Cited.
Adaptive radiation in a heterogeneous environment.
P B Rainey, M Travisano.
Nature, 1998 Jul 17; 394(6688). PMID: 9665128
Highly Cited.
Histological types of breast cancer: how special are they?
Britta Weigelt, Felipe C Geyer, Jorge S Reis-Filho.
Mol Oncol, 2010 May 11; 4(3). PMID: 20452298    Free PMC article.
Highly Cited. Review.
Metronomic chemotherapy: new rationale for new directions.
Eddy Pasquier, Maria Kavallaris, Nicolas André.
Nat Rev Clin Oncol, 2010 Jun 10; 7(8). PMID: 20531380
Highly Cited. Review.
Tracing the tumor lineage.
Nicholas E Navin, James Hicks.
Mol Oncol, 2010 Jun 12; 4(3). PMID: 20537601    Free PMC article.
The role of the microenvironment in mammary gland development and cancer.
Kornelia Polyak, Raghu Kalluri.
Cold Spring Harb Perspect Biol, 2010 Jul 02; 2(11). PMID: 20591988    Free PMC article.
Highly Cited. Review.
Progress in understanding melanoma propagation.
Mark Shackleton, Elsa Quintana.
Mol Oncol, 2010 Jul 27; 4(5). PMID: 20655286    Free PMC article.
Review.
How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine.
M Gerlinger, C Swanton.
Br J Cancer, 2010 Sep 30; 103(8). PMID: 20877357    Free PMC article.
Highly Cited. Review.
Molecular markers for the diagnosis and management of ductal carcinoma in situ.
Kornelia Polyak.
J Natl Cancer Inst Monogr, 2010 Oct 20; 2010(41). PMID: 20956832    Free PMC article.
Review.
Heterogeneity Between Ducts of the Same Nuclear Grade Involved by Duct Carcinoma In Situ (DCIS) of the Breast.
Naomi A Miller, Judith-Anne W Chapman, +5 authors, David E Axelrod.
Cancer Inform, 2010 Oct 29; 9. PMID: 20981137    Free PMC article.
Are cancer stem cells radioresistant?
Walter N Hittelman, Yong Liao, Li Wang, Luka Milas.
Future Oncol, 2010 Nov 11; 6(10). PMID: 21062156    Free PMC article.
Review.
Genetic variegation of clonal architecture and propagating cells in leukaemia.
Kristina Anderson, Christoph Lutz, +10 authors, Mel Greaves.
Nature, 2010 Dec 17; 469(7330). PMID: 21160474
Highly Cited.
Metastasis suppressor genes at the interface between the environment and tumor cell growth.
Douglas R Hurst, Danny R Welch.
Int Rev Cell Mol Biol, 2011 Jan 05; 286. PMID: 21199781    Free PMC article.
Review.
New strategies in the molecular targeting of glioblastoma: how do you hit a moving target?
Timothy F Cloughesy, Paul S Mischel.
Clin Cancer Res, 2011 Jan 07; 17(1). PMID: 21208902    Free PMC article.
Multivariate analysis of a 3D mass spectral image for examining tissue heterogeneity.
Wolfgang Reindl, Benjamin P Bowen, +2 authors, Trent R Northen.
Integr Biol (Camb), 2011 Jan 08; 3(4). PMID: 21212877    Free PMC article.
Cells of origin in cancer.
Jane E Visvader.
Nature, 2011 Jan 21; 469(7330). PMID: 21248838
Highly Cited. Review.
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.
Faiyaz Notta, Charles G Mullighan, +7 authors, John E Dick.
Nature, 2011 Jan 21; 469(7330). PMID: 21248843
Highly Cited.
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097.
Wei He, Leopoldo Luistro, +10 authors, John F Boylan.
Mol Oncol, 2011 Feb 15; 5(3). PMID: 21315665    Free PMC article.
Gene signatures of breast cancer progression and metastasis.
David I Rodenhiser, Joseph D Andrews, Theodore A Vandenberg, Ann F Chambers.
Breast Cancer Res, 2011 Feb 25; 13(1). PMID: 21345283    Free PMC article.
Review.
Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors.
Teodora Evgenieva Goranova, Masayuki Ohue, Yutaro Shimoharu, Kikuya Kato.
Clin Exp Metastasis, 2011 Mar 08; 28(5). PMID: 21380628    Free PMC article.
Metabolic trade-offs and the maintenance of the fittest and the flattest.
Robert E Beardmore, Ivana Gudelj, David A Lipson, Laurence D Hurst.
Nature, 2011 Mar 29; 472(7343). PMID: 21441905
Evolving role of molecular imaging with PET in detecting and characterizing heterogeneity of cancer tissue at the primary and metastatic sites, a plausible explanation for failed attempts to cure malignant disorders.
Sandip Basu, Thomas C Kwee, +3 authors, Abass Alavi.
Eur J Nucl Med Mol Imaging, 2011 Apr 01; 38(6). PMID: 21451997
Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs.
Arup Bhattacharya.
Expert Opin Drug Deliv, 2011 Apr 09; 8(6). PMID: 21473705    Free PMC article.
Review.
Heterogeneity of anticancer drug sensitivity in squamous cell carcinoma of the tongue.
Minako Suzuki, Hiroshi Ishikawa, Akira Tanaka, Izumi Mataga.
Hum Cell, 2011 May 07; 24(1). PMID: 21547692
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
Lauren L C Marotta, Vanessa Almendro, +25 authors, Kornelia Polyak.
J Clin Invest, 2011 Jun 03; 121(7). PMID: 21633165    Free PMC article.
Highly Cited.
High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers.
Kimberly D Siegmund, Paul Marjoram, Simon Tavaré, Darryl Shibata.
PLoS One, 2011 Jul 09; 6(6). PMID: 21738754    Free PMC article.
Heterogeneity in breast cancer.
Kornelia Polyak.
J Clin Invest, 2011 Oct 04; 121(10). PMID: 21965334    Free PMC article.
Highly Cited.
Insight into the heterogeneity of breast cancer through next-generation sequencing.
Hege G Russnes, Nicholas Navin, James Hicks, Anne-Lise Borresen-Dale.
J Clin Invest, 2011 Oct 04; 121(10). PMID: 21965338    Free PMC article.
Highly Cited. Review.
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Piero Dalerba, Tomer Kalisky, +19 authors, Stephen R Quake.
Nat Biotechnol, 2011 Nov 15; 29(12). PMID: 22081019    Free PMC article.
Highly Cited.
Heterogeneity of breast cancer: etiology and clinical relevance.
V Almendro, G Fuster.
Clin Transl Oncol, 2011 Nov 16; 13(11). PMID: 22082639
Review.
Targeted enrichment of genomic DNA regions for next-generation sequencing.
Florian Mertes, Abdou Elsharawy, +6 authors, Anthony J Brookes.
Brief Funct Genomics, 2011 Nov 29; 10(6). PMID: 22121152    Free PMC article.
Review.
Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells.
Qihui Shi, Lidong Qin, +7 authors, James R Heath.
Proc Natl Acad Sci U S A, 2011 Dec 29; 109(2). PMID: 22203961    Free PMC article.
Highly Cited.
Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells.
Douglas Edmund Feldman, Chialin Chen, +2 authors, Keigo Machida.
Proc Natl Acad Sci U S A, 2011 Dec 31; 109(3). PMID: 22207628    Free PMC article.
Clonal evolution in cancer.
Mel Greaves, Carlo C Maley.
Nature, 2012 Jan 20; 481(7381). PMID: 22258609    Free PMC article.
Highly Cited. Review.
Heterogeneity of chemosensitivity in esophageal cancer using ATP-tumor chemosensitivity assay.
Zhi-qiang Ling, Chun-jian Qi, +9 authors, Wei-min Mao.
Acta Pharmacol Sin, 2012 Jan 31; 33(3). PMID: 22286916    Free PMC article.
Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance.
Bálint Tegze, Zoltán Szállási, +4 authors, Balázs Gyorffy.
PLoS One, 2012 Feb 10; 7(2). PMID: 22319589    Free PMC article.
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.
Jiyoung Kim, René Villadsen, +12 authors, Ole William Petersen.
Proc Natl Acad Sci U S A, 2012 Mar 29; 109(16). PMID: 22454501    Free PMC article.
Molecular prescreening to select patient population in early clinical trials.
Jordi Rodón, Cristina Saura, +4 authors, Josep Tabernero.
Nat Rev Clin Oncol, 2012 Apr 05; 9(6). PMID: 22473105
Review.
Intra-tumour heterogeneity: a looking glass for cancer?
Andriy Marusyk, Vanessa Almendro, Kornelia Polyak.
Nat Rev Cancer, 2012 Apr 20; 12(5). PMID: 22513401
Highly Cited. Review.
Comprehensive assessment of potential multiple myeloma immunoglobulin heavy chain V-D-J intraclonal variation using massively parallel pyrosequencing.
Renee C Tschumper, Yan W Asmann, +5 authors, Diane F Jelinek.
Oncotarget, 2012 Apr 24; 3(4). PMID: 22522905    Free PMC article.
Tumor heterogeneity and its implication for drug delivery.
Tracy A Denison, You Han Bae.
J Control Release, 2012 Apr 28; 164(2). PMID: 22537887    Free PMC article.
Review.
Spatial regulation of receptor tyrosine kinases in development and cancer.
Jessica B Casaletto, Andrea I McClatchey.
Nat Rev Cancer, 2012 May 25; 12(6). PMID: 22622641    Free PMC article.
Highly Cited. Review.
Inter and intratumour heterogeneity: a barrier to individualized medical therapy in renal cell carcinoma?
Rosalie Fisher, James Larkin, Charles Swanton.
Front Oncol, 2012 Jun 02; 2. PMID: 22655275    Free PMC article.
Monitoring enzymatic degradation of pericellular matrices through SERS stamping.
Bo Yan, Yan Hong, Tianhong Chen, Björn M Reinhard.
Nanoscale, 2012 Jun 05; 4(13). PMID: 22659641    Free PMC article.
Endosialin expression in side populations in human sarcoma cell lines.
Cecile Rouleau, Jose Sancho, Juanita Campos-Rivera, Beverly A Teicher.
Oncol Lett, 2012 Jun 29; 3(2). PMID: 22740905    Free PMC article.
Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients.
Jian-Hua Yu, Jing-Tao Dong, +5 authors, Wen-Tong Meng.
Chin J Cancer, 2012 Jul 11; 32(4). PMID: 22776235    Free PMC article.
Defining the mode of tumour growth by clonal analysis.
Gregory Driessens, Benjamin Beck, +2 authors, Cédric Blanpain.
Nature, 2012 Aug 03; 488(7412). PMID: 22854777    Free PMC article.
Highly Cited.
Reversible adaptive plasticity: a mechanism for neuroblastoma cell heterogeneity and chemo-resistance.
Lina Chakrabarti, Thamara Abou-Antoun, Stanislav Vukmanovic, Anthony D Sandler.
Front Oncol, 2012 Aug 15; 2. PMID: 22891161    Free PMC article.
Using functional genomics to overcome therapeutic resistance in hematological malignancies.
Francesca Alvarez-Calderon, Mark A Gregory, James DeGregori.
Immunol Res, 2012 Sep 04; 55(1-3). PMID: 22941562    Free PMC article.
Review.
The transcriptional landscape and mutational profile of lung adenocarcinoma.
Jeong-Sun Seo, Young Seok Ju, +17 authors, Young Tae Kim.
Genome Res, 2012 Sep 15; 22(11). PMID: 22975805    Free PMC article.
Highly Cited.
Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma.
Harry H Yoon, Qian Shi, +7 authors, Frank A Sinicrope.
J Clin Oncol, 2012 Sep 19; 30(32). PMID: 22987085    Free PMC article.
A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma.
Elise Bonvin, Paola Falletta, +2 authors, Colin R Goding.
Mol Cell Biol, 2012 Sep 19; 32(22). PMID: 22988297    Free PMC article.
Quantum dots as a platform for nanoparticle drug delivery vehicle design.
Christine E Probst, Pavel Zrazhevskiy, Vaishali Bagalkot, Xiaohu Gao.
Adv Drug Deliv Rev, 2012 Sep 25; 65(5). PMID: 23000745    Free PMC article.
Review.
The mechanics of metastasis: insights from a computational model.
G Wayne Brodland, Jim H Veldhuis.
PLoS One, 2012 Oct 03; 7(9). PMID: 23028513    Free PMC article.
Human correlates of provocative questions in pancreatic pathology.
Oliver G McDonald, Anirban Maitra, Ralph H Hruban.
Adv Anat Pathol, 2012 Oct 13; 19(6). PMID: 23060061    Free PMC article.
Review.
Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.
Andrea Sottoriva, Inmaculada Spiteri, +2 authors, Simon Tavaré.
Cancer Res, 2012 Oct 24; 73(1). PMID: 23090114    Free PMC article.
Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.
Johannes Fredebohm, Michael Boettcher, +9 authors, Jörg D Hoheisel.
PLoS One, 2012 Nov 16; 7(11). PMID: 23152778    Free PMC article.
The problem of colliding networks and its relation to cell fusion and cancer.
Alexei A Koulakov, Yuri Lazebnik.
Biophys J, 2012 Dec 04; 103(9). PMID: 23199929    Free PMC article.
Three-dimensional mRNA measurements reveal minimal regional heterogeneity in esophageal squamous cell carcinoma.
Wusheng Yan, Joanna Shih, +11 authors, Heidi S Erickson.
Am J Pathol, 2012 Dec 12; 182(2). PMID: 23219752    Free PMC article.
Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.
René Meyer, Lorenza A D'Alessandro, +12 authors, Ursula Klingmüller.
Front Physiol, 2012 Dec 12; 3. PMID: 23226133    Free PMC article.
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review).
Jie Zheng.
Oncol Lett, 2012 Dec 12; 4(6). PMID: 23226794    Free PMC article.
Highly Cited.
Sequential therapy with targeted agents in metastatic renal cell carcinoma: beyond second-line and overcoming drug resistance.
Muhammad Khattak, James Larkin.
World J Urol, 2013 Jan 09; 32(1). PMID: 23297098
Review.
Cancer heterogeneity: implications for targeted therapeutics.
R Fisher, L Pusztai, C Swanton.
Br J Cancer, 2013 Jan 10; 108(3). PMID: 23299535    Free PMC article.
Highly Cited. Review.
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model.
Shawn P Carey, Alina Starchenko, Alexandra L McGregor, Cynthia A Reinhart-King.
Clin Exp Metastasis, 2013 Jan 19; 30(5). PMID: 23328900    Free PMC article.
High-throughput sequencing for biology and medicine.
Wendy Weijia Soon, Manoj Hariharan, Michael P Snyder.
Mol Syst Biol, 2013 Jan 24; 9. PMID: 23340846    Free PMC article.
Highly Cited. Review.
Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction.
Minsuk Kwak, Luye Mu, +3 authors, Rong Fan.
Front Oncol, 2013 Feb 08; 3. PMID: 23390614    Free PMC article.
From forest and agro-ecosystems to the microecosystems of the human body: what can landscape ecology tell us about tumor growth, metastasis, and treatment options?
Simon P Daoust, Lenore Fahrig, Amanda E Martin, Frédéric Thomas.
Evol Appl, 2013 Feb 12; 6(1). PMID: 23396712    Free PMC article.
Applying ecological and evolutionary theory to cancer: a long and winding road.
Frédéric Thomas, Daniel Fisher, +35 authors, Michael E Hochberg.
Evol Appl, 2013 Feb 12; 6(1). PMID: 23397042    Free PMC article.
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.
Andrea Sottoriva, Inmaculada Spiteri, +6 authors, Simon Tavaré.
Proc Natl Acad Sci U S A, 2013 Feb 16; 110(10). PMID: 23412337    Free PMC article.
Highly Cited.
Mechanisms and insights into drug resistance in cancer.
Hiba Zahreddine, Katherine L B Borden.
Front Pharmacol, 2013 Mar 19; 4. PMID: 23504227    Free PMC article.
Highly Cited.
Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.
Allison B Chambliss, Pei-Hsun Wu, +2 authors, Denis Wirtz.
FASEB J, 2013 Mar 30; 27(7). PMID: 23538711    Free PMC article.
Strategies for isolating and enriching cancer stem cells: well begun is half done.
Jiang-Jie Duan, Wen Qiu, +6 authors, Shi-Cang Yu.
Stem Cells Dev, 2013 Apr 02; 22(16). PMID: 23540661    Free PMC article.
Review.
Mass spectrometry imaging for in situ kinetic histochemistry.
Katherine B Louie, Benjamin P Bowen, +5 authors, Trent R Northen.
Sci Rep, 2013 Apr 16; 3. PMID: 23584513    Free PMC article.
Phenotypic drift as a cause for intratumoral morphological heterogeneity of invasive ductal breast carcinoma not otherwise specified.
Marina V Zavyalova, Evgeny V Denisov, +8 authors, Vladimir M Perelmuter.
Biores Open Access, 2013 Apr 18; 2(2). PMID: 23593567    Free PMC article.
Automating tumor classification with pixel-by-pixel contrast-enhanced ultrasound perfusion kinetics.
Casey N Ta, Yuko Kono, +2 authors, Andrew C Kummel.
J Vac Sci Technol B Nanotechnol Microelectron, 2013 Apr 26; 30(2). PMID: 23616934    Free PMC article.
Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells.
C-H Olme, N Brown, +2 authors, C Badie.
Mutat Res, 2013 May 15; 756(1-2). PMID: 23665297    Free PMC article.
Understanding and targeting cancer stem cells: therapeutic implications and challenges.
Ke Chen, Ying-hui Huang, Ji-long Chen.
Acta Pharmacol Sin, 2013 May 21; 34(6). PMID: 23685952    Free PMC article.
Highly Cited. Review.
How cancer shapes evolution, and how evolution shapes cancer.
Matias Casás-Selves, James Degregori.
Evolution (N Y), 2011 Dec 01; 4(4). PMID: 23705033    Free PMC article.
Coexistence of two different mutations in codon 12 of the Kras gene in colorectal cancer: Report of a case supporting the concept of tumoral heterogeneity.
Giuseppina Improta, Angela Zupa, +6 authors, Giulia Vita.
Oncol Lett, 2013 Jun 14; 5(5). PMID: 23761841    Free PMC article.
Culture of low passage colorectal cancer cells and demonstration of variation in selected tumour marker expression.
Melanie Arul, April Camilla Roslani, Colin Leong Liong Ng, Swee Hung Cheah.
Cytotechnology, 2013 Jul 05; 66(3). PMID: 23824584    Free PMC article.
A robust method to analyze copy number alterations of less than 100 kb in single cells using oligonucleotide array CGH.
Birte Möhlendick, Christoph Bartenhagen, +4 authors, Nikolas H Stoecklein.
PLoS One, 2013 Jul 05; 8(6). PMID: 23825608    Free PMC article.
Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis.
Mohana Ray, Steve Goldstein, +7 authors, David C Schwartz.
BMC Genomics, 2013 Jul 28; 14. PMID: 23885787    Free PMC article.
Evolutionary game theory of growth factor production: implications for tumour heterogeneity and resistance to therapies.
M Archetti.
Br J Cancer, 2013 Aug 08; 109(4). PMID: 23922110    Free PMC article.
A possible explanation for the variable frequencies of cancer stem cells in tumors.
Renato Vieira dos Santos, Linaena Méricy da Silva.
PLoS One, 2013 Aug 21; 8(8). PMID: 23950884    Free PMC article.
Dissecting social cell biology and tumors using Drosophila genetics.
José Carlos Pastor-Pareja, Tian Xu.
Annu Rev Genet, 2013 Aug 31; 47. PMID: 23988119    Free PMC article.
Review.
Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4(+) cells with tumor-initiating capability.
Lawrence S Gazda, Prithy C Martis, +4 authors, Barry H Smith.
Cancer Biol Ther, 2013 Sep 13; 14(12). PMID: 24025409    Free PMC article.
Predicting pathologic tumor response to chemoradiotherapy with histogram distances characterizing longitudinal changes in 18F-FDG uptake patterns.
Shan Tan, Hao Zhang, +3 authors, Wei Lu.
Med Phys, 2013 Oct 05; 40(10). PMID: 24089897    Free PMC article.
Cancer cell metabolism: implications for therapeutic targets.
Miran Jang, Sung Soo Kim, Jinhwa Lee.
Exp Mol Med, 2013 Oct 05; 45. PMID: 24091747    Free PMC article.
Highly Cited. Review.
Can nanomedicines kill cancer stem cells?
Yi Zhao, Daria Y Alakhova, Alexander V Kabanov.
Adv Drug Deliv Rev, 2013 Oct 15; 65(13-14). PMID: 24120657    Free PMC article.
Review.
Exposome informatics: considerations for the design of future biomedical research information systems.
Fernando Martin Sanchez, Kathleen Gray, Riccardo Bellazzi, Guillermo Lopez-Campos.
J Am Med Inform Assoc, 2013 Nov 05; 21(3). PMID: 24186958    Free PMC article.
Modeling pathologic response of esophageal cancer to chemoradiation therapy using spatial-temporal 18F-FDG PET features, clinical parameters, and demographics.
Hao Zhang, Shan Tan, +5 authors, Wei Lu.
Int J Radiat Oncol Biol Phys, 2013 Nov 06; 88(1). PMID: 24189128    Free PMC article.
A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype.
Jonas Wolf, Dyah Laksmi Dewi, +4 authors, Michael Boettcher.
Breast Cancer Res, 2013 Nov 16; 15(6). PMID: 24229464    Free PMC article.
Isolation of melanoma cell subpopulations using negative selection.
Ana Slipicevic, Rajasekharan Somasundaram, Katrin Sproesser, Meenhard Herlyn.
Methods Mol Biol, 2013 Nov 22; 1102. PMID: 24258995    Free PMC article.
Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity.
Yuanjie Hu, Ning Ru, +18 authors, Yi-Hong Zhou.
PLoS One, 2013 Nov 28; 8(11). PMID: 24282558    Free PMC article.
Role of primary tumor resection among chemotherapy-treated patients with synchronous stage IV colorectal cancer: a survival analysis.
Walter Y Tsang, Argyrios Ziogas, +4 authors, Jason A Zell.
J Gastrointest Surg, 2013 Dec 04; 18(3). PMID: 24297651    Free PMC article.
Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway.
L Bizzozero, D Cazzato, +10 authors, C Perrotta.
Cell Death Differ, 2013 Dec 10; 21(4). PMID: 24317198    Free PMC article.
Niche-dependent gene expression profile of intratumoral heterogeneous ovarian cancer stem cell populations.
Sagi Abelson, Yeela Shamai, +2 authors, Maty Tzukerman.
PLoS One, 2013 Dec 21; 8(12). PMID: 24358304    Free PMC article.
Keeping an open mind: highlights and controversies of the breast cancer stem cell theory.
Mansi Shah, Cinzia Allegrucci.
Breast Cancer (Dove Med Press), 2012 Jan 01; 4. PMID: 24367202    Free PMC article.
Review.
Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation.
Lei Tang, Anne L van de Ven, +4 authors, Xiaobo Zhou.
PLoS One, 2014 Jan 10; 9(1). PMID: 24404145    Free PMC article.
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.
Dominik Sturm, Sebastian Bender, +12 authors, Stefan M Pfister.
Nat Rev Cancer, 2014 Jan 25; 14(2). PMID: 24457416    Free PMC article.
Highly Cited. Review.
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.
Vanessa Almendro, Yu-Kang Cheng, +18 authors, Kornelia Polyak.
Cell Rep, 2014 Jan 28; 6(3). PMID: 24462293    Free PMC article.
Highly Cited.
Glioblastoma multiforme: a look inside its heterogeneous nature.
Maria-Del-Mar Inda, Rudy Bonavia, Joan Seoane.
Cancers (Basel), 2014 Jan 30; 6(1). PMID: 24473088    Free PMC article.
Dynamics of growth factor production in monolayers of cancer cells and evolution of resistance to anticancer therapies.
Marco Archetti.
Evol Appl, 2014 Jan 31; 6(8). PMID: 24478797    Free PMC article.
Evolutionarily stable anti-cancer therapies by autologous cell defection.
Marco Archetti.
Evol Med Public Health, 2014 Feb 01; 2013(1). PMID: 24481196    Free PMC article.
Inferring clonal evolution of tumors from single nucleotide somatic mutations.
Wei Jiao, Shankar Vembu, +2 authors, Quaid Morris.
BMC Bioinformatics, 2014 Feb 04; 15. PMID: 24484323    Free PMC article.
Highly Cited.
Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.
Lifen Cao, Long Shan Li, +17 authors, David A Boothman.
Antioxid Redox Signal, 2014 Feb 12; 21(2). PMID: 24512128    Free PMC article.
Genetic Heterogeneity and Clonal Evolution of Tumor Cells and their Impact on Precision Cancer Medicine.
Hatem E Sabaawy.
J Leuk (Los Angel), 2014 Feb 22; 1(4). PMID: 24558642    Free PMC article.
Estimating dose painting effects in radiotherapy: a mathematical model.
Juan Carlos López Alfonso, Nick Jagiella, +2 authors, Dirk Drasdo.
PLoS One, 2014 Mar 04; 9(2). PMID: 24586734    Free PMC article.
Cancer stem cells in glioma: challenges and opportunities.
Jialiang Wang, Yufang Ma, Michael K Cooper.
Transl Cancer Res, 2014 Mar 19; 2(5). PMID: 24634854    Free PMC article.
In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies.
Martina McDermott, Alex J Eustace, +5 authors, Britta Stordal.
Front Oncol, 2014 Mar 19; 4. PMID: 24639951    Free PMC article.
Highly Cited.
How to get the most from microarray data: advice from reverse genomics.
Ivan P Gorlov, Ji-Yeon Yang, +4 authors, Christopher Amos.
BMC Genomics, 2014 Mar 25; 15. PMID: 24656147    Free PMC article.
Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers.
Allison S Cleary, Travis L Leonard, Shelley A Gestl, Edward J Gunther.
Nature, 2014 Apr 04; 508(7494). PMID: 24695311    Free PMC article.
Highly Cited.
Identification of intrinsic imaging phenotypes for breast cancer tumors: preliminary associations with gene expression profiles.
Ahmed Bilal Ashraf, Dania Daye, +4 authors, Despina Kontos.
Radiology, 2014 Apr 08; 272(2). PMID: 24702725    Free PMC article.
Parametric imaging of ¹⁸F-fluoro-3-deoxy-3-L-fluorothymidine PET data to investigate tumour heterogeneity.
M Veronese, G Rizzo, E O Aboagye, A Bertoldo.
Eur J Nucl Med Mol Imaging, 2014 Apr 08; 41(9). PMID: 24705620
Prognostic and predictive biomarkers in adult and pediatric gliomas: toward personalized treatment.
Harry R Haynes, Sandra Camelo-Piragua, Kathreena M Kurian.
Front Oncol, 2014 Apr 10; 4. PMID: 24716189    Free PMC article.
Review.
Linking differential radiation responses to glioma heterogeneity.
Chao Ke, Katherine Tran, +7 authors, Yi-Hong Zhou.
Oncotarget, 2014 Apr 12; 5(6). PMID: 24722169    Free PMC article.
Challenges and Approaches to Quantitative Therapy Response Assessment in Glioblastoma Multiforme Using the Novel Apoptosis Positron Emission Tomography Tracer F-18 ML-10.
Matthew J Oborski, Charles M Laymon, +3 authors, James M Mountz.
Transl Oncol, 2014 Apr 29; 7(1). PMID: 24772214    Free PMC article.
Increased copy number of the DLX4 homeobox gene in breast axillary lymph node metastasis.
Clarissa Torresan, Márcia M C Oliveira, +9 authors, Luciane R Cavalli.
Cancer Genet, 2014 Jun 21; 207(5). PMID: 24947980    Free PMC article.
Zebrafish as a model to assess cancer heterogeneity, progression and relapse.
Jessica S Blackburn, David M Langenau.
Dis Model Mech, 2014 Jun 29; 7(7). PMID: 24973745    Free PMC article.
Review.
SAOS-2 osteosarcoma cells bind fibroblasts via ICAM-1 and this is increased by tumour necrosis factor-α.
Manu S David, Elizabeth Kelly, +3 authors, Hans Zoellner.
PLoS One, 2014 Jul 01; 9(6). PMID: 24979620    Free PMC article.
Microfluidic 3D models of cancer.
Kyung Eun Sung, David J Beebe.
Adv Drug Deliv Rev, 2014 Jul 16; 79-80. PMID: 25017040    Free PMC article.
Review.
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome.
Erika Ortolan, Alice Giacomino, +11 authors, Ada Funaro.
Oncotarget, 2014 Jul 16; 5(15). PMID: 25026285    Free PMC article.
Cutaneous carcinosarcoma: further insights into its mutational landscape through massive parallel genome sequencing.
Alberto Paniz-Mondolfi, Rajesh Singh, +8 authors, Rajyalakshmi Luthra.
Virchows Arch, 2014 Jul 18; 465(3). PMID: 25031014
Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.
Salim Akhter Chowdhury, Stanley E Shackney, +3 authors, Russell Schwartz.
PLoS Comput Biol, 2014 Aug 01; 10(7). PMID: 25078894    Free PMC article.
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.
Andriy Marusyk, Doris P Tabassum, +3 authors, Kornelia Polyak.
Nature, 2014 Aug 01; 514(7520). PMID: 25079331    Free PMC article.
Highly Cited.
Can we negotiate with a tumor?
Claire M Wolfrom, Michel Laurent, Jean Deschatrette.
PLoS One, 2014 Aug 02; 9(8). PMID: 25084359    Free PMC article.
Exploring the competition between proliferative and invasive cancer phenotypes in a continuous spatial model.
Eleftheria Tzamali, Georgios Grekas, Konstantinos Marias, Vangelis Sakkalis.
PLoS One, 2014 Aug 08; 9(8). PMID: 25099885    Free PMC article.
Global gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia.
Magdalena Olbryt, Anna Habryka, +3 authors, Katarzyna Marta Lisowska.
PLoS One, 2014 Aug 15; 9(8). PMID: 25122487    Free PMC article.
Illuminating breast cancer invasion: diverse roles for cell-cell interactions.
Kevin J Cheung, Andrew J Ewald.
Curr Opin Cell Biol, 2014 Aug 20; 30. PMID: 25137487    Free PMC article.
Review.
A short update on cancer chemoresistance.
Gerhard Hamilton, Barbara Rath.
Wien Med Wochenschr, 2014 Sep 25; 164(21-22). PMID: 25249024
Review.
Integrative analysis of cancer imaging readouts by networks.
Marco Dominietto, Nicholas Tsinoremas, Enrico Capobianco.
Mol Oncol, 2014 Sep 30; 9(1). PMID: 25263240    Free PMC article.
Review.
Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.
Janice M Spence, Andrew Abumoussa, John P Spence, W Richard Burack.
J Immunol, 2014 Oct 15; 193(10). PMID: 25311808    Free PMC article.
Disseminated cerebellar hemangioblastoma in two patients without von Hippel-Lindau disease.
Jiro Akimoto, Hirokazu Fukuhara, +3 authors, Kohno Michihiro.
Surg Neurol Int, 2014 Oct 18; 5. PMID: 25324974    Free PMC article.
Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth.
Chiswili Chabu, Tian Xu.
Development, 2014 Nov 21; 141(24). PMID: 25411211    Free PMC article.
Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor.
Shengwen Calvin Li, Lisa May Ling Tachiki, +3 authors, William G Loudon.
Cancer Cell Int, 2014 Nov 21; 14(1). PMID: 25411563    Free PMC article.
Radiochemotherapy-induced changes of tumour vascularity and blood supply estimated by dynamic contrast-enhanced CT and fractal analysis in malignant head and neck tumours.
A Abramyuk, V Hietschold, +2 authors, N Abolmaali.
Br J Radiol, 2014 Nov 21; 88(1045). PMID: 25412001    Free PMC article.
Role of liver stem cells in hepatocarcinogenesis.
Lei-Bo Xu, Chao Liu.
World J Stem Cells, 2014 Nov 27; 6(5). PMID: 25426254    Free PMC article.
Review.
Correlation between plasma DNA and tumor status in an animal model.
Naoko Sueoka-Aragane, Akemi Sato, +6 authors, Shinya Kimura.
PLoS One, 2014 Dec 03; 9(12). PMID: 25462870    Free PMC article.
Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis.
Deepika Neelakantan, David J Drasin, Heide L Ford.
Cell Adh Migr, 2014 Dec 09; 9(4). PMID: 25482627    Free PMC article.
Review.
Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung.
Hibiki Udagawa, Genichiro Ishii, +9 authors, Yuichiro Ohe.
J Cancer Res Clin Oncol, 2015 Jan 13; 141(8). PMID: 25573625
A droplet digital PCR detection method for rare L1 insertions in tumors.
Travis B White, Adam M McCoy, +2 authors, Prescott L Deininger.
Mob DNA, 2015 Jan 20; 5(1). PMID: 25598847    Free PMC article.
Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia.
Simone Ecker, Vera Pancaldi, Daniel Rico, Alfonso Valencia.
Genome Med, 2015 Jan 30; 7(1). PMID: 25632304    Free PMC article.
Computerized PET/CT image analysis in the evaluation of tumour response to therapy.
W Lu, J Wang, H H Zhang.
Br J Radiol, 2015 Feb 28; 88(1048). PMID: 25723599    Free PMC article.
Review.
Cancer stem cells--the current status of an old concept: literature review and clinical approaches.
Lukasz Fulawka, Piotr Donizy, Agnieszka Halon.
Biol Res, 2015 Feb 28; 47. PMID: 25723910    Free PMC article.
Review.
Molecular heterogeneity in glioblastoma: potential clinical implications.
Nicole Renee Parker, Peter Khong, +2 authors, Helen Ruth Wheeler.
Front Oncol, 2015 Mar 19; 5. PMID: 25785247    Free PMC article.
Highly Cited. Review.
PhyloWGS: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors.
Amit G Deshwar, Shankar Vembu, +3 authors, Quaid Morris.
Genome Biol, 2015 Mar 19; 16. PMID: 25786235    Free PMC article.
Highly Cited.
Genetic heterogeneity of circulating cells from patients with lymphangioleiomyomatosis with and without lung transplantation.
Wendy K Steagall, Li Zhang, +2 authors, Joel Moss.
Am J Respir Crit Care Med, 2015 Apr 02; 191(7). PMID: 25830522    Free PMC article.
Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients.
Jian Li, Zhijuan Deng, +13 authors, Xinyuan Guan.
Oncotarget, 2015 Apr 02; 6(10). PMID: 25831050    Free PMC article.
Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation.
Janice M Spence, John P Spence, Andrew Abumoussa, W Richard Burack.
Genome Med, 2015 Apr 16; 7(1). PMID: 25874000    Free PMC article.
Drug sensitivity in cancer cell lines is not tissue-specific.
Samira Jaeger, Miquel Duran-Frigola, Patrick Aloy.
Mol Cancer, 2015 Apr 17; 14. PMID: 25881072    Free PMC article.
A tumor deconstruction platform identifies definitive end points in the evaluation of drug responses.
R R Naik, A K Singh, +2 authors, S A Bapat.
Oncogene, 2015 Apr 29; 35(6). PMID: 25915841
Breast cancer intra-tumor heterogeneity.
Luciano G Martelotto, Charlotte K Y Ng, +2 authors, Jorge S Reis-Filho.
Breast Cancer Res, 2014 Jan 01; 16(3). PMID: 25928070    Free PMC article.
Highly Cited. Review.
Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents.
Elham Alizadeh Pasdar, Michael Smits, +15 authors, Jiri Neuzil.
PLoS One, 2015 May 02; 10(5). PMID: 25932953    Free PMC article.
From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity.
Marc Aubry, Marie de Tayrac, +4 authors, Jean Mosser.
Oncotarget, 2015 May 06; 6(14). PMID: 25940437    Free PMC article.
Selection of a breast cancer subpopulation-specific antibody using phage display on tissue sections.
Simon Asbjørn Larsen, Theresa Meldgaard, +6 authors, Peter Kristensen.
Immunol Res, 2015 May 13; 62(3). PMID: 25963139    Free PMC article.
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
Ricardo de Matos Simoes, Sabine Dalleau, Kate E Williamson, Frank Emmert-Streib.
BMC Syst Biol, 2015 May 15; 9. PMID: 25971253    Free PMC article.
Pathology to enhance precision medicine in oncology: lessons from landscape ecology.
Mark C Lloyd, Katarzyna A Rejniak, +3 authors, Marilyn M Bui.
Adv Anat Pathol, 2015 Jun 08; 22(4). PMID: 26050264    Free PMC article.
Review.
Breast DCE-MRI Kinetic Heterogeneity Tumor Markers: Preliminary Associations With Neoadjuvant Chemotherapy Response.
Ahmed Ashraf, Bilwaj Gaonkar, +4 authors, Despina Kontos.
Transl Oncol, 2015 Jun 10; 8(3). PMID: 26055172    Free PMC article.
Inferring models of multiscale copy number evolution for single-tumor phylogenetics.
Salim Akhter Chowdhury, E Michael Gertz, +4 authors, Russell Schwartz.
Bioinformatics, 2015 Jun 15; 31(12). PMID: 26072490    Free PMC article.
Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay.
Jin Zhang, Hongxia Li.
Oncol Lett, 2015 Jul 03; 9(5). PMID: 26137074    Free PMC article.
Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies.
Giovanni Brandi, Andrea Farioli, +2 authors, Simona Tavolari.
Oncotarget, 2015 Jul 06; 6(17). PMID: 26142706    Free PMC article.
Review.
A High Throughput Micro-Chamber Array Device for Single Cell Clonal Cultivation and Tumor Heterogeneity Analysis.
Feng-Min Shen, Lian Zhu, +3 authors, Zhi-Ling Zhang.
Sci Rep, 2015 Jul 08; 5. PMID: 26149707    Free PMC article.
Tumorigenesis: it takes a village.
Doris P Tabassum, Kornelia Polyak.
Nat Rev Cancer, 2015 Jul 15; 15(8). PMID: 26156638
Highly Cited. Review.
Harnessing Pandemonium: The Clinical Implications of Tumor Heterogeneity in Ovarian Cancer.
Sarah P Blagden.
Front Oncol, 2015 Jul 16; 5. PMID: 26175968    Free PMC article.
Review.
Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures.
Richard Novak, Kristina Hart, Richard A Mathies.
Nucleic Acids Res, 2015 Jul 24; 43(16). PMID: 26202962    Free PMC article.
Uncovering metabolism in rhabdomyosarcoma.
Eugenio Monti, Alessandro Fanzani.
Cell Cycle, 2015 Jul 26; 15(2). PMID: 26209235    Free PMC article.
Review.
The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis.
Adam Myszczyszyn, Anna M Czarnecka, +7 authors, Cezary Szczylik.
Stem Cell Rev Rep, 2015 Jul 27; 11(6). PMID: 26210994    Free PMC article.
Review.
Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.
Wiltrud Haaß, Helga Kleiner, +3 authors, Wolfgang Seifarth.
PLoS One, 2015 Aug 13; 10(8). PMID: 26267133    Free PMC article.
Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models.
Jiyun Kim, Kandice Tanner.
Front Oncol, 2015 Aug 19; 5. PMID: 26284194    Free PMC article.
Review.
Preliminary Study of MR Diffusion Tensor Imaging of the Liver for the Diagnosis of Hepatocellular Carcinoma.
Xinghui Li, Qi Liang, +7 authors, Jiani Hu.
PLoS One, 2015 Sep 01; 10(8). PMID: 26317346    Free PMC article.
Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication.
Minjong Lee, Jung-Hwan Yoon.
World J Biol Chem, 2015 Sep 01; 6(3). PMID: 26322173    Free PMC article.
Review.
Classifying the Progression of Ductal Carcinoma from Single-Cell Sampled Data via Integer Linear Programming: A Case Study.
Daniele Catanzaro, Stanley E Shackney, Alejandro A Schaffer, Russell Schwartz.
IEEE/ACM Trans Comput Biol Bioinform, 2015 Sep 10; 13(4). PMID: 26353381    Free PMC article.
A multilevel pan-cancer map links gene mutations to cancer hallmarks.
Theo A Knijnenburg, Tycho Bismeijer, Lodewyk F A Wessels, Ilya Shmulevich.
Chin J Cancer, 2015 Sep 16; 34(10). PMID: 26369414    Free PMC article.
Transcriptomic Heterogeneity in Cancer as a Consequence of Dysregulation of the Gene-Gene Interaction Network.
Wessel N van Wieringen, Aad W van der Vaart.
Bull Math Biol, 2015 Sep 18; 77(9). PMID: 26376888    Free PMC article.
A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer?
Alireza Mirzaei, Gholamreza Tavoosidana, +5 authors, Zahra Madjd.
Tumour Biol, 2015 Sep 19; 37(2). PMID: 26383518
CHIMERA: Clustering of Heterogeneous Disease Effects via Distribution Matching of Imaging Patterns.
Aoyan Dong, Nicolas Honnorat, Bilwaj Gaonkar, Christos Davatzikos.
IEEE Trans Med Imaging, 2015 Oct 10; 35(2). PMID: 26452275    Free PMC article.
Novel delivery approaches for cancer therapeutics.
Ashim K Mitra, Vibhuti Agrahari, +10 authors, Dhananjay Pal.
J Control Release, 2015 Oct 13; 219. PMID: 26456750    Free PMC article.
Review.
The mini-driver model of polygenic cancer evolution.
Francesc Castro-Giner, Peter Ratcliffe, Ian Tomlinson.
Nat Rev Cancer, 2015 Oct 13; 15(11). PMID: 26456849
Review.
Challenges of deciphering gastric cancer heterogeneity.
Petra Hudler.
World J Gastroenterol, 2015 Oct 13; 21(37). PMID: 26457012    Free PMC article.
Review.
Cytokeratin 5-Positive Cells Represent a Therapy Resistant subpopulation in Epithelial Ovarian Cancer.
Bradley R Corr, Jessica Finlay-Schultz, +5 authors, Carol A Sartorius.
Int J Gynecol Cancer, 2015 Oct 27; 25(9). PMID: 26495758    Free PMC article.
Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells.
Jaya M Matharage, John D Minna, Rolf A Brekken, D Gomika Udugamasooriya.
ACS Chem Biol, 2015 Oct 29; 10(12). PMID: 26509598    Free PMC article.
Bub1 is required for maintaining cancer stem cells in breast cancer cell lines.
Jeong Yoon Han, Yu Kyeong Han, +2 authors, Chang Geun Lee.
Sci Rep, 2015 Nov 03; 5. PMID: 26522589    Free PMC article.
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
Shaoping Ling, Zheng Hu, +21 authors, Chung-I Wu.
Proc Natl Acad Sci U S A, 2015 Nov 13; 112(47). PMID: 26561581    Free PMC article.
Highly Cited.
Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers.
Manuel Scimeca, Chiara Antonacci, +3 authors, Elena Bonanno.
Tumour Biol, 2015 Nov 14; 37(4). PMID: 26563370
CancerResource--updated database of cancer-relevant proteins, mutations and interacting drugs.
Bjoern-Oliver Gohlke, Janette Nickel, +2 authors, Robert Preissner.
Nucleic Acids Res, 2015 Nov 22; 44(D1). PMID: 26590406    Free PMC article.
Determination of regional lymph node status using (18)F-FDG PET/CT parameters in oesophageal cancer patients: comparison of SUV, volumetric parameters and intratumoral heterogeneity.
Seong-Jang Kim, Kyoungjune Pak, Samuel Chang.
Br J Radiol, 2015 Nov 27; 89(1058). PMID: 26607643    Free PMC article.
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.
Noemi Andor, Trevor A Graham, +5 authors, Carlo C Maley.
Nat Med, 2015 Dec 01; 22(1). PMID: 26618723    Free PMC article.
Highly Cited.
Positive expression of NANOG, mutant p53, and CD44 is directly associated with clinicopathological features and poor prognosis of oral squamous cell carcinoma.
Hye-Jin Lee, Young-Hoon Kang, +5 authors, Bong-Wook Park.
BMC Oral Health, 2015 Dec 03; 15(1). PMID: 26626427    Free PMC article.
18F-FDG PET-Derived Textural Indices Reflect Tissue-Specific Uptake Pattern in Non-Small Cell Lung Cancer.
Fanny Orlhac, Michaël Soussan, +2 authors, Irène Buvat.
PLoS One, 2015 Dec 17; 10(12). PMID: 26669541    Free PMC article.
Differential expression of neurogenes among breast cancer subtypes identifies high risk patients.
Patricia Fernández-Nogueira, Paloma Bragado, +5 authors, Pedro Gascón.
Oncotarget, 2015 Dec 18; 7(5). PMID: 26673618    Free PMC article.
In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment.
Amy T Shah, Kirsten E Diggins, +2 authors, Melissa C Skala.
Neoplasia, 2015 Dec 24; 17(12). PMID: 26696368    Free PMC article.
Targeting Notch to overcome radiation resistance.
Sanaz Yahyanejad, Jan Theys, Marc Vooijs.
Oncotarget, 2015 Dec 30; 7(7). PMID: 26713603    Free PMC article.
Review.
A simple engineered platform reveals different modes of tumor-microenvironmental cell interaction.
Chentian Zhang, Elizabeth M Shenk, +4 authors, Joyce Y Wong.
Biofabrication, 2015 Dec 31; 8(1). PMID: 26716792    Free PMC article.
Imaging metabolic heterogeneity in cancer.
Debanti Sengupta, Guillem Pratx.
Mol Cancer, 2016 Jan 08; 15. PMID: 26739333    Free PMC article.
Review.
Highly multiplexed targeted DNA sequencing from single nuclei.
Marco L Leung, Yong Wang, +4 authors, Nicholas E Navin.
Nat Protoc, 2016 Jan 08; 11(2). PMID: 26741407    Free PMC article.
Enhanced and Differential Capture of Circulating Tumor Cells from Lung Cancer Patients by Microfluidic Assays Using Aptamer Cocktail.
Libo Zhao, Chuanhao Tang, +12 authors, Xiaohong Fang.
Small, 2016 Jan 15; 12(8). PMID: 26763166    Free PMC article.
Promiscuous tumor targeting phage proteins.
Amanda L Gross, James W Gillespie, Valery A Petrenko.
Protein Eng Des Sel, 2016 Jan 15; 29(3). PMID: 26764410    Free PMC article.
Fluorescence Lifetime Imaging of Apoptosis.
Annie Xiao, Anne E Gibbons, Kathryn E Luker, Gary D Luker.
Tomography, 2016 Jan 16; 1(2). PMID: 26771007    Free PMC article.
Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.
Eun Young Kim, Eun Na Cho, +6 authors, Yoon Soo Chang.
BMC Cancer, 2016 Jan 20; 16. PMID: 26782967    Free PMC article.
Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals.
Liang Shi, Hui Lin, +7 authors, Chawnshang Chang.
Cancer Lett, 2016 Jan 26; 373(1). PMID: 26805759    Free PMC article.
Quantification of read species behavior within whole genome sequencing of cancer genomes for the stratification and visualization of genomic variation.
Dror Hibsh, Kenneth H Buetow, Gur Yaari, Sol Efroni.
Nucleic Acids Res, 2016 Jan 27; 44(9). PMID: 26809676    Free PMC article.
Analysis of single nucleic acid molecules in micro- and nano-fluidics.
Sarah M Friedrich, Helena C Zec, Tza-Huei Wang.
Lab Chip, 2016 Jan 29; 16(5). PMID: 26818700    Free PMC article.
Review.
COSMOS: accurate detection of somatic structural variations through asymmetric comparison between tumor and normal samples.
Koichi Yamagata, Ayako Yamanishi, +2 authors, Jun Sese.
Nucleic Acids Res, 2016 Feb 03; 44(8). PMID: 26833260    Free PMC article.
Associating spatial diversity features of radiologically defined tumor habitats with epidermal growth factor receptor driver status and 12-month survival in glioblastoma: methods and preliminary investigation.
Joonsang Lee, Shivali Narang, +2 authors, Arvind Rao.
J Med Imaging (Bellingham), 2016 Feb 03; 2(4). PMID: 26835490    Free PMC article.
Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.
Kristofor A Olson, John C Schell, Jared Rutter.
Trends Biochem Sci, 2016 Feb 14; 41(3). PMID: 26873641    Free PMC article.
Review.
Stem Cell Modeling of Core Binding Factor Acute Myeloid Leukemia.
Federico Mosna, Michele Gottardi.
Stem Cells Int, 2016 Feb 18; 2016. PMID: 26880987    Free PMC article.
Review.
Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.
Michael Ramirez, Satwik Rajaram, +13 authors, Steven J Altschuler.
Nat Commun, 2016 Feb 20; 7. PMID: 26891683    Free PMC article.
Highly Cited.
Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response.
James M Greene, Doron Levy, +2 authors, Orit Lavi.
Cancer Res, 2016 Mar 05; 76(10). PMID: 26933088    Free PMC article.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
Danny N Khalil, Eric L Smith, Renier J Brentjens, Jedd D Wolchok.
Nat Rev Clin Oncol, 2016 Mar 16; 13(5). PMID: 26977780    Free PMC article.
Highly Cited. Review.
The metabolic interaction of cancer cells and fibroblasts - coupling between NAD(P)H and FAD, intracellular pH and hydrogen peroxide.
Irina N Druzhkova, Marina V Shirmanova, +3 authors, Elena V Zagaynova.
Cell Cycle, 2016 Mar 18; 15(9). PMID: 26986068    Free PMC article.
Cell-free circulating tumor DNA in cancer.
Zhen Qin, Vladimir A Ljubimov, +2 authors, Jimin Liang.
Chin J Cancer, 2016 Apr 09; 35. PMID: 27056366    Free PMC article.
Review.
Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness.
Bram Cerulus, Aaron M New, Ksenia Pougach, Kevin J Verstrepen.
Curr Biol, 2016 Apr 14; 26(9). PMID: 27068419    Free PMC article.
Omics Profiling in Precision Oncology.
Kun-Hsing Yu, Michael Snyder.
Mol Cell Proteomics, 2016 Apr 22; 15(8). PMID: 27099341    Free PMC article.
Review.
Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.
Alexander Nguyen, Mitsukuni Yoshida, Hani Goodarzi, Sohail F Tavazoie.
Nat Commun, 2016 May 04; 7. PMID: 27138336    Free PMC article.
Elucidation of molecular and functional heterogeneity through differential expression network analyses of discrete tumor subsets.
Rutika R Naik, Nilesh L Gardi, Sharmila A Bapat.
Sci Rep, 2016 May 04; 6. PMID: 27140846    Free PMC article.
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
Stefano La Rosa, Fausto Sessa, Silvia Uccella.
Endocr Pathol, 2016 May 14; 27(4). PMID: 27169712
Review.
Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment.
Natalia Malara, Valentina Trunzo, +12 authors, Vincenzo Mollace.
J Transl Med, 2016 May 14; 14(1). PMID: 27176720    Free PMC article.
Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers.
Praful R Nair, S A Karthick, +3 authors, Dennis E Discher.
Nanomedicine (Lond), 2016 May 14; 11(12). PMID: 27177319    Free PMC article.
Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
Jian-Ye Zhang, Min-Ting Lin, +6 authors, Hu-Biao Chen.
Am J Cancer Res, 2016 May 18; 6(4). PMID: 27186433    Free PMC article.
Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis.
Hao Wang, Yang Yu, +6 authors, Hong Zhang.
Sci Rep, 2016 May 25; 6. PMID: 27217076    Free PMC article.
Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology.
Laura M Desrochers, Marc A Antonyak, Richard A Cerione.
Dev Cell, 2016 May 25; 37(4). PMID: 27219060    Free PMC article.
Highly Cited. Review.
Decoding transcriptional enhancers: Evolving from annotation to functional interpretation.
Krysta L Engel, Mark Mackiewicz, +2 authors, Daniel Savic.
Semin Cell Dev Biol, 2016 May 26; 57. PMID: 27224938    Free PMC article.
Review.
Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer.
Soochi Kim, Boyun Kim, Yong Sang Song.
Cancer Sci, 2016 Jun 15; 107(9). PMID: 27297561    Free PMC article.
Review.
ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer.
Haiyan Sun, Christopher G England, +7 authors, Weibo Cai.
Eur J Nucl Med Mol Imaging, 2016 Jun 28; 43(12). PMID: 27342417    Free PMC article.
Cancer stem cells (CSCs), cervical CSCs and targeted therapies.
Ruixia Huang, Einar K Rofstad.
Oncotarget, 2016 Jun 28; 8(21). PMID: 27343550    Free PMC article.
Review.
FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.
E Michael Gertz, Salim Akhter Chowdhury, +5 authors, Alejandro A Schäffer.
PLoS One, 2016 Jul 01; 11(6). PMID: 27362268    Free PMC article.
Enhancing Antitumor Immune Responses by Optimized Combinations of Cell-penetrating Peptide-based Vaccines and Adjuvants.
Elodie Belnoue, Wilma Di Berardino-Besson, +11 authors, Madiha Derouazi.
Mol Ther, 2016 Jul 06; 24(9). PMID: 27377043    Free PMC article.
Tumour heterogeneity: principles and practical consequences.
Giorgio Stanta, Stephan Wenzel Jahn, Serena Bonin, Gerald Hoefler.
Virchows Arch, 2016 Jul 15; 469(4). PMID: 27412632
Review.
The link between diffusion MRI and tumor heterogeneity: Mapping cell eccentricity and density by diffusional variance decomposition (DIVIDE).
Filip Szczepankiewicz, Danielle van Westen, +5 authors, Markus Nilsson.
Neuroimage, 2016 Jul 28; 142. PMID: 27450666    Free PMC article.
Highly Cited.
Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy.
Cong Luo, Jin Sun, +9 authors, Zhonggui He.
Nano Lett, 2016 Aug 05; 16(9). PMID: 27490088    Free PMC article.
A Cross-Sectional Comparison of Druggable Mutations in Primary Tumors, Metastatic Tissue, Circulating Tumor Cells, and Cell-Free Circulating DNA in Patients with Metastatic Breast Cancer: The MIRROR Study Protocol.
Milagros Gonzalez-Rivera, Antoni C Picornell, Enrique L Alvarez, Miguel Martin.
JMIR Res Protoc, 2016 Aug 18; 5(3). PMID: 27531554    Free PMC article.
CloneCNA: detecting subclonal somatic copy number alterations in heterogeneous tumor samples from whole-exome sequencing data.
Zhenhua Yu, Ao Li, Minghui Wang.
BMC Bioinformatics, 2016 Aug 20; 17. PMID: 27538789    Free PMC article.
Primary and metastatic tumor dormancy as a result of population heterogeneity.
Irina Kareva.
Biol Direct, 2016 Aug 24; 11. PMID: 27549396    Free PMC article.
Clonal cooperativity in heterogenous cancers.
Hengbo Zhou, Deepika Neelakantan, Heide L Ford.
Semin Cell Dev Biol, 2016 Sep 02; 64. PMID: 27582427    Free PMC article.
Review.
On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer.
Judith Penkert, Tim Ripperger, +3 authors, Thomas Illig.
Oncotarget, 2016 Sep 04; 7(41). PMID: 27590516    Free PMC article.
Review.
Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma.
Yan Deng, Qing Pang, +7 authors, Chang Liu.
Onco Targets Ther, 2016 Sep 08; 9. PMID: 27601923    Free PMC article.
TumorNext: A comprehensive tumor profiling assay that incorporates high resolution copy number analysis and germline status to improve testing accuracy.
Phillip N Gray, Huy Vuong, +18 authors, Aaron Elliott.
Oncotarget, 2016 Sep 15; 7(42). PMID: 27626691    Free PMC article.
Metastasis and Circulating Tumor Cells.
Guus van Dalum, Linda Holland, Leon Wmm Terstappen.
EJIFCC, 2012 Oct 01; 23(3). PMID: 27683421    Free PMC article.
An Integrated Analysis of the Genome-Wide Profiles of DNA Methylation and mRNA Expression Defining the Side Population of a Human Malignant Mesothelioma Cell Line.
Myung-Chul Kim, Na-Yon Kim, Yu-Ri Seo, Yongbaek Kim.
J Cancer, 2016 Oct 05; 7(12). PMID: 27698904    Free PMC article.
Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance.
Yingjiao Xue, Shenda Hou, Hongbin Ji, Xiangkun Han.
Protein Cell, 2016 Oct 21; 8(3). PMID: 27757846    Free PMC article.
Review.
Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.
Daphne Sun, Simona Dalin, +2 authors, Boyang Zhao.
Sci Rep, 2016 Nov 08; 6. PMID: 27819268    Free PMC article.
Screening and characterization of novel specific peptides targeting MDA-MB-231 claudin-low breast carcinoma by computer-aided phage display methodologies.
Franklin L Nobrega, Débora Ferreira, +4 authors, Lígia R Rodrigues.
BMC Cancer, 2016 Nov 16; 16(1). PMID: 27842517    Free PMC article.
Radiation injury vs. recurrent brain metastasis: combining textural feature radiomics analysis and standard parameters may increase 18F-FET PET accuracy without dynamic scans.
Philipp Lohmann, Gabriele Stoffels, +9 authors, Norbert Galldiks.
Eur Radiol, 2016 Nov 18; 27(7). PMID: 27853813
Positron emission tomography/computerized tomography for tumor response assessment-a review of clinical practices and radiomics studies.
Wei Lu, Wengen Chen.
Transl Cancer Res, 2016 Dec 03; 5(4). PMID: 27904837    Free PMC article.
Evolutionary scalpels for dissecting tumor ecosystems.
Daniel I S Rosenbloom, Pablo G Camara, Tim Chu, Raul Rabadan.
Biochim Biophys Acta Rev Cancer, 2016 Dec 08; 1867(2). PMID: 27923679    Free PMC article.
Review.
Stochastic phenotypic interconversion in tumors can generate heterogeneity.
Giuseppina Simone.
Eur Biophys J, 2016 Dec 13; 46(2). PMID: 27942765
Understanding molecular markers in recurrent oral squamous cell carcinoma treated with chemoradiation.
Seema Gupta, Vandana Singh Kushwaha, +6 authors, Ashim Ghatak.
Heliyon, 2016 Dec 17; 2(12). PMID: 27981249    Free PMC article.
Inherent variability of cancer-specific aneuploidy generates metastases.
Mathew Bloomfield, Peter Duesberg.
Mol Cytogenet, 2016 Dec 27; 9. PMID: 28018487    Free PMC article.
Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Lacey E Dobrolecki, Susie D Airhart, +29 authors, Michael T Lewis.
Cancer Metastasis Rev, 2016 Dec 28; 35(4). PMID: 28025748    Free PMC article.
Highly Cited. Review.
Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer.
Huw Geraint Jones, Gareth Jenkins, +4 authors, Dean Harris.
World J Surg, 2017 Jan 18; 41(5). PMID: 28097409    Free PMC article.
Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer.
Rehman Ata, Costin N Antonescu.
Int J Mol Sci, 2017 Jan 21; 18(1). PMID: 28106780    Free PMC article.
Review.
Tumor evolution: Linear, branching, neutral or punctuated?
Alexander Davis, Ruli Gao, Nicholas Navin.
Biochim Biophys Acta Rev Cancer, 2017 Jan 23; 1867(2). PMID: 28110020    Free PMC article.
Highly Cited. Review.
Links between DNA Replication, Stem Cells and Cancer.
Alex Vassilev, Melvin L DePamphilis.
Genes (Basel), 2017 Jan 27; 8(2). PMID: 28125050    Free PMC article.
Review.
Graph-theoretical model of global human interactome reveals enhanced long-range communicability in cancer networks.
Evgeny Gladilin.
PLoS One, 2017 Feb 01; 12(1). PMID: 28141819    Free PMC article.
Changing mutational and adaptive landscapes and the genesis of cancer.
L Alexander Liggett, James DeGregori.
Biochim Biophys Acta Rev Cancer, 2017 Feb 09; 1867(2). PMID: 28167050    Free PMC article.
Review.
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature.
Artem Kaznatcheev, Robert Vander Velde, Jacob G Scott, David Basanta.
Br J Cancer, 2017 Feb 10; 116(6). PMID: 28183139    Free PMC article.
Oncolytic viruses: emerging options for the treatment of breast cancer.
Yogesh R Suryawanshi, Tiantian Zhang, Karim Essani.
Med Oncol, 2017 Feb 12; 34(3). PMID: 28185165
Review.
Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype.
Shawn P Carey, Karen E Martin, Cynthia A Reinhart-King.
Sci Rep, 2017 Feb 12; 7. PMID: 28186196    Free PMC article.
Highly Cited.
The evolution of tumour phylogenetics: principles and practice.
Russell Schwartz, Alejandro A Schäffer.
Nat Rev Genet, 2017 Feb 14; 18(4). PMID: 28190876    Free PMC article.
Highly Cited. Review.
Advances in understanding tumour evolution through single-cell sequencing.
Jack Kuipers, Katharina Jahn, Niko Beerenwinkel.
Biochim Biophys Acta Rev Cancer, 2017 Feb 15; 1867(2). PMID: 28193548    Free PMC article.
Review.
PET/MR in invasive ductal breast cancer: correlation between imaging markers and histological phenotype.
Onofrio Antonio Catalano, Gary Lloyd Horn, +11 authors, Bruce Robert Rosen.
Br J Cancer, 2017 Feb 17; 116(7). PMID: 28208155    Free PMC article.
Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.
Yuan Yuan Wang, Camille Attané, +18 authors, Catherine Muller.
JCI Insight, 2017 Feb 28; 2(4). PMID: 28239646    Free PMC article.
Highly Cited.
Metabolic origins of spatial organization in the tumor microenvironment.
Carlos Carmona-Fontaine, Maxime Deforet, +3 authors, Joao B Xavier.
Proc Natl Acad Sci U S A, 2017 Mar 02; 114(11). PMID: 28246332    Free PMC article.
Highly Cited.
Cancer: A disease at the crossroads of trade-offs.
Camille Jacqueline, Peter A Biro, +6 authors, Frédéric Thomas.
Evol Appl, 2017 Mar 03; 10(3). PMID: 28250806    Free PMC article.
Current Insights to Regulation and Role of Telomerase in Human Diseases.
Mert Burak Ozturk, Yinghui Li, Vinay Tergaonkar.
Antioxidants (Basel), 2017 Mar 08; 6(1). PMID: 28264499    Free PMC article.
Review.
Gut microbiota modulation of chemotherapy efficacy and toxicity.
James L Alexander, Ian D Wilson, +3 authors, James M Kinross.
Nat Rev Gastroenterol Hepatol, 2017 Mar 09; 14(6). PMID: 28270698
Highly Cited. Review.
The heterogeneity of cancer stem-like cells at the invasive front.
Go J Yoshida.
Cancer Cell Int, 2017 Mar 16; 17. PMID: 28289330    Free PMC article.
Diverse Applications of Nanomedicine.
Beatriz Pelaz, Christoph Alexiou, +83 authors, Wolfgang J Parak.
ACS Nano, 2017 Mar 16; 11(3). PMID: 28290206    Free PMC article.
Highly Cited. Review.
A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity.
Jing Hu, Gang Li, +2 authors, Guohong Hu.
Cell Death Dis, 2017 Mar 17; 8(3). PMID: 28300837    Free PMC article.
[When is cytoreductive nephrectomy not beneficial for patients with metastatic renal cell carcinoma?]
Martin Schostak.
Urologe A, 2017 Mar 21; 56(5). PMID: 28314968
Review.
Antibody Engineering for Pursuing a Healthier Future.
Abdullah F U H Saeed, Rongzhi Wang, Sumei Ling, Shihua Wang.
Front Microbiol, 2017 Apr 13; 8. PMID: 28400756    Free PMC article.
Review.
Modeling Tumor Clonal Evolution for Drug Combinations Design.
Boyang Zhao, Michael T Hemann, Douglas A Lauffenburger.
Trends Cancer, 2017 Apr 25; 2(3). PMID: 28435907    Free PMC article.
Review.
Applications of pHLIP Technology for Cancer Imaging and Therapy.
Linden C Wyatt, Jason S Lewis, +2 authors, Donald M Engelman.
Trends Biotechnol, 2017 Apr 26; 35(7). PMID: 28438340    Free PMC article.
Review.
Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes.
Mumtahena Rahman, Shelley M MacNeil, +8 authors, Andrea H Bild.
Genome Med, 2017 Apr 28; 9(1). PMID: 28446242    Free PMC article.
Enrichment and single-cell analysis of circulating tumor cells.
Yanling Song, Tian Tian, +6 authors, Chaoyong Yang.
Chem Sci, 2017 Apr 30; 8(3). PMID: 28451298    Free PMC article.
Evidence of drug-response heterogeneity rapidly generated from a single cancer cell.
Rong Wang, Chengmeng Jin, Xun Hu.
Oncotarget, 2017 May 04; 8(25). PMID: 28467802    Free PMC article.
A subset of microRNAs defining the side population of a human malignant mesothelioma cell line.
Myung-Chul Kim, Na-Yon Kim, Yu-Ri Seo, Yongbaek Kim.
Oncotarget, 2017 May 04; 8(26). PMID: 28467812    Free PMC article.
SinCHet: a MATLAB toolbox for single cell heterogeneity analysis in cancer.
Jiannong Li, Inna Smalley, +2 authors, Y Ann Chen.
Bioinformatics, 2017 May 05; 33(18). PMID: 28472395    Free PMC article.
Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems.
Anish Babu, Anupama Munshi, Rajagopal Ramesh.
Drug Dev Ind Pharm, 2017 May 20; 43(9). PMID: 28523942    Free PMC article.
Gender-related prognostic value and genomic pattern of intra-tumor heterogeneity in colorectal cancer.
Jieyun Zhang, Shican Yan, +6 authors, Weijian Guo.
Carcinogenesis, 2017 May 23; 38(8). PMID: 28531253    Free PMC article.
A unique mid-sequence linker used to multimerize the lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1.
Satya Prakash Shukla, Joseph C Manarang, D Gomika Udugamasooriya.
Eur J Med Chem, 2017 May 30; 137. PMID: 28551176    Free PMC article.
Coexistence of and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity.
Pegah Larki, Ehsan Gharib, +3 authors, Hamid Asadzadeh Aghdaei.
Cell J, 2017 Jun 06; 19(Suppl 1). PMID: 28580315    Free PMC article.
Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus.
Emily J Simon, Morgan A Howells, Johnasha D Stuart, Karl W Boehme.
Viruses, 2017 Jun 08; 9(6). PMID: 28587298    Free PMC article.
Plasma T790M and HGF as potential predictive markers for EGFR-TKI re-challenge.
Tomomi Nakamura, Naomi Watanabe, +7 authors, Naoko Sueoka-Aragane.
Oncol Lett, 2017 Jun 08; 13(6). PMID: 28588734    Free PMC article.
Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy.
Yu Winston Wang, Nicholas P Reder, +6 authors, Jonathan T C Liu.
Cancer Res, 2017 Jun 16; 77(16). PMID: 28615226    Free PMC article.
Precision medicine in breast cancer: reality or utopia?
Ali Bettaieb, Catherine Paul, +3 authors, François Ghiringhelli.
J Transl Med, 2017 Jun 19; 15(1). PMID: 28623955    Free PMC article.
Review.
CT texture features are associated with overall survival in pancreatic ductal adenocarcinoma - a quantitative analysis.
Armin Eilaghi, Sameer Baig, +5 authors, Masoom A Haider.
BMC Med Imaging, 2017 Jun 21; 17(1). PMID: 28629416    Free PMC article.
Highly Cited.
Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity.
Ivy A W Ho, Winston S N Shim.
Biomed Res Int, 2017 Jun 21; 2017. PMID: 28630875    Free PMC article.
Review.
Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score.
Sunitha B Thakur, Manuela Durando, +5 authors, Elizabeth A Morris.
J Magn Reson Imaging, 2017 Jun 24; 47(2). PMID: 28640531    Free PMC article.
The Potential Value of Preoperative MRI Texture and Shape Analysis in Grading Meningiomas: A Preliminary Investigation.
Peng-Fei Yan, Ling Yan, +4 authors, Jun Feng.
Transl Oncol, 2017 Jun 28; 10(4). PMID: 28654820    Free PMC article.
Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.
Odessa Schillaci, Simona Fontana, +4 authors, Riccardo Alessandro.
Sci Rep, 2017 Jul 07; 7(1). PMID: 28680152    Free PMC article.
Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
J Rodriguez-Blanco, L Pednekar, +12 authors, D J Robbins.
Oncogene, 2017 Jul 18; 36(45). PMID: 28714964    Free PMC article.
Breast cancer complexity: implications of intratumoral heterogeneity in clinical management.
Brittany Haynes, Ashapurna Sarma, Pratima Nangia-Makker, Malathy P Shekhar.
Cancer Metastasis Rev, 2017 Jul 29; 36(3). PMID: 28752247    Free PMC article.
Review.
Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation.
Lőrinc Pongor, Hajnalka Harami-Papp, +2 authors, Balázs Győrffy.
Sci Rep, 2017 Aug 06; 7(1). PMID: 28779157    Free PMC article.
Role of depth of response and MTHFR genotype as predictors of fluorouracil rechallenge therapy for refractory metastatic colorectal cancer.
Ka-Rham Kim, Jung-Hwan Yoon, +6 authors, Sang-Hee Cho.
Oncol Lett, 2017 Aug 07; 14(2). PMID: 28781687    Free PMC article.
An open-pattern droplet-in-oil planar array for single cell analysis based on sequential inkjet printing technology.
Chenyu Wang, Wenwen Liu, +2 authors, Yude Yu.
Biomicrofluidics, 2017 Aug 11; 11(4). PMID: 28794816    Free PMC article.
Identification of breast cancer mechanism based on weighted gene coexpression network analysis.
X Guo, H Xiao, +2 authors, J Chen.
Cancer Gene Ther, 2017 Aug 12; 24(8). PMID: 28799567
Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes.
Joseph X Zhou, Roberto Taramelli, +2 authors, Sui Huang.
Sci Rep, 2017 Aug 20; 7(1). PMID: 28821810    Free PMC article.
Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models.
William K Decker, Rodrigo F da Silva, +5 authors, Silke Paust.
Front Immunol, 2017 Aug 22; 8. PMID: 28824608    Free PMC article.
Highly Cited. Review.
Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis.
Scott Haston, Saba Manshaei, Juan Pedro Martinez-Barbera.
J Endocrinol, 2017 Sep 01; 236(1). PMID: 28855316    Free PMC article.
Review.
Data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI.
Adam K Featherstone, James P B O'Connor, +6 authors, Geoff J M Parker.
Magn Reson Med, 2017 Sep 01; 79(4). PMID: 28856728    Free PMC article.
Chemotherapeutic dosing implicated by pharmacodynamic modeling of in vitro cytotoxic data: a case study of paclitaxel.
Hua He, Yanguang Cao.
J Pharmacokinet Pharmacodyn, 2017 Sep 02; 44(5). PMID: 28861682    Free PMC article.
Non-cell-autonomous effects yield lower clonal diversity in expanding tumors.
Tazzio Tissot, Frédéric Thomas, Benjamin Roche.
Sci Rep, 2017 Sep 13; 7(1). PMID: 28894191    Free PMC article.
Current Progresses of Single Cell DNA Sequencing in Breast Cancer Research.
Jianlin Liu, Ragini Adhav, Xiaoling Xu.
Int J Biol Sci, 2017 Sep 20; 13(8). PMID: 28924377    Free PMC article.
Review.
2D and 3D texture analysis to differentiate brain metastases on MR images: proceed with caution.
Monika Béresová, Andrés Larroza, +3 authors, David Moratal.
MAGMA, 2017 Sep 25; 31(2). PMID: 28939952
Elastographic Assessment of Xenograft Pancreatic Tumors.
Hexuan Wang, Michael D Nieskoski, +4 authors, Marvin M Doyley.
Ultrasound Med Biol, 2017 Oct 02; 43(12). PMID: 28964615    Free PMC article.
Evaluation of digital PCR for detecting low-level EGFR mutations in advanced lung adenocarcinoma patients: a cross-platform comparison study.
Jincui Gu, Wanchun Zang, +6 authors, Yanbin Zhou.
Oncotarget, 2017 Oct 06; 8(40). PMID: 28978074    Free PMC article.
Alternative mechanisms of miR-34a regulation in cancer.
Eva Slabáková, Zoran Culig, Ján Remšík, Karel Souček.
Cell Death Dis, 2017 Oct 13; 8(10). PMID: 29022903    Free PMC article.
Highly Cited. Review.
Tumor radiomic heterogeneity: Multiparametric functional imaging to characterize variability and predict response following cervical cancer radiation therapy.
Stephen R Bowen, William T C Yuh, +11 authors, Nina A Mayr.
J Magn Reson Imaging, 2017 Oct 19; 47(5). PMID: 29044908    Free PMC article.
PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer.
Jill J J Geenen, Sabine C Linn, Jos H Beijnen, Jan H M Schellens.
Clin Pharmacokinet, 2017 Oct 25; 57(4). PMID: 29063517
Review.
Multiplexed Optical Imaging of Tumor-Directed Nanoparticles: A Review of Imaging Systems and Approaches.
Yu Winston Wang, Nicholas P Reder, +2 authors, Jonathan T C Liu.
Nanotheranostics, 2017 Oct 27; 1(4). PMID: 29071200    Free PMC article.
Review.
Intratumor and Intertumor Heterogeneity in Melanoma.
Tomasz M Grzywa, Wiktor Paskal, Paweł K Włodarski.
Transl Oncol, 2017 Oct 28; 10(6). PMID: 29078205    Free PMC article.
Highly Cited. Review.
Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker.
Ru Wang, Xiao Li, +2 authors, Jianjun He.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088906    Free PMC article.
Review.
The biology and mathematical modelling of glioma invasion: a review.
J C L Alfonso, K Talkenberger, +5 authors, A Deutsch.
J R Soc Interface, 2017 Nov 10; 14(136). PMID: 29118112    Free PMC article.
Review.
Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer.
Andrija Matak, Pooja Lahiri, +5 authors, Kurt Zatloukal.
Hepatology, 2017 Nov 25; 68(3). PMID: 29171037    Free PMC article.
Quantitative, in situ analysis of mRNAs and proteins with subcellular resolution.
Sunjong Kwon, Koei Chin, Michel Nederlof, Joe W Gray.
Sci Rep, 2017 Dec 01; 7(1). PMID: 29184166    Free PMC article.
Tumor cell-intrinsic phenotypic plasticity facilitates adaptive cellular reprogramming driving acquired drug resistance.
Heinz Hammerlindl, Helmut Schaider.
J Cell Commun Signal, 2017 Dec 02; 12(1). PMID: 29192388    Free PMC article.
Review.
Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeutics.
Himadri Patel, Pritish Nilendu, +2 authors, Nilesh Kumar Sharma.
Cancer Biol Ther, 2017 Dec 09; 19(1). PMID: 29219656    Free PMC article.
Review.
Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity.
Elisabet Cuyàs, Sara Verdura, +4 authors, Javier A Menendez.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29245896    Free PMC article.
A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma.
Varda Shoshan-Barmatz, Yael Bishitz, +6 authors, Yael Refaely.
Oncotarget, 2017 Dec 30; 8(62). PMID: 29285267    Free PMC article.
Model-driven discovery of long-chain fatty acid metabolic reprogramming in heterogeneous prostate cancer cells.
Igor Marín de Mas, Esther Aguilar, +6 authors, Marta Cascante.
PLoS Comput Biol, 2018 Jan 03; 14(1). PMID: 29293497    Free PMC article.
Linking invasive motility to protein expression in single tumor cells.
Jung-Ming G Lin, Chi-Chih Kang, +3 authors, Sanjay Kumar.
Lab Chip, 2018 Jan 05; 18(2). PMID: 29299576    Free PMC article.
Nanoparticles in the clinic.
Aaron C Anselmo, Samir Mitragotri.
Bioeng Transl Med, 2016 Jun 03; 1(1). PMID: 29313004    Free PMC article.
Highly Cited. Review.
Galectin-3 and cancer stemness.
Pratima Nangia-Makker, Victor Hogan, Avraham Raz.
Glycobiology, 2018 Jan 10; 28(4). PMID: 29315388    Free PMC article.
Review.
Solute carrier transporters: potential targets for digestive system neoplasms.
Jing Xie, Xiao Yan Zhu, Lu Ming Liu, Zhi Qiang Meng.
Cancer Manag Res, 2018 Feb 09; 10. PMID: 29416375    Free PMC article.
Review.
Immune Landscape of Breast Cancers.
Divya Nagarajan, Stephanie E B McArdle.
Biomedicines, 2018 Feb 15; 6(1). PMID: 29439457    Free PMC article.
Review.
Biological noise and positional effects influence cell stemness.
Walter Blum, Thomas Henzi, Beat Schwaller, László Pecze.
J Biol Chem, 2018 Feb 15; 293(14). PMID: 29440274    Free PMC article.
Nanomechanical Phenotype of Melanoma Cells Depends Solely on the Amount of Endogenous Pigment in the Cells.
Michal Sarna, Andrzej Zadlo, Barbara Czuba-Pelech, Krystyna Urbanska.
Int J Mol Sci, 2018 Feb 22; 19(2). PMID: 29463035    Free PMC article.
Metastatic site as a predictor of nivolumab efficacy in patients with advanced non-small cell lung cancer: A retrospective multicenter trial.
Motohiro Tamiya, Akihiro Tamiya, +12 authors, Fumio Imamura.
PLoS One, 2018 Feb 23; 13(2). PMID: 29470536    Free PMC article.
Highly Cited.
Single cell whole genome sequencing reveals that NFKB1 mutation affects radiotherapy sensitivity in cervical cancer.
Dong Yang, Weiyuan Zhang, +4 authors, Wenjing Hao.
Oncotarget, 2018 Feb 28; 9(7). PMID: 29484114    Free PMC article.
Variable Cell Line Pharmacokinetics Contribute to Non-Linear Treatment Response in Heterogeneous Cell Populations.
Matthew T McKenna, Jared A Weis, Vito Quaranta, Thomas E Yankeelov.
Ann Biomed Eng, 2018 Feb 28; 46(6). PMID: 29484528    Free PMC article.
Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors.
Linden C Wyatt, Anna Moshnikova, +3 authors, Yana K Reshetnyak.
Proc Natl Acad Sci U S A, 2018 Mar 07; 115(12). PMID: 29507241    Free PMC article.
Highly Cited.
Homologue-specific chromosome sequencing characterizes translocation junctions and permits allelic assignment.
Fumio Kasai, Jorge C Pereira, Arihiro Kohara, Malcolm A Ferguson-Smith.
DNA Res, 2018 Mar 09; 25(4). PMID: 29518182    Free PMC article.
A mini-library system to investigate non-essential residues of lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1.
Satya Prakash Shukla, D Gomika Udugamasooriya.
Medchemcomm, 2018 Mar 13; 8(12). PMID: 29527284    Free PMC article.
The heterogenic tumor microenvironment of hepatocellular carcinoma and prognostic analysis based on tumor neo-vessels, macrophages and α-SMA.
Min Fang, Jingping Yuan, +6 authors, Ming Chen.
Oncol Lett, 2018 Mar 20; 15(4). PMID: 29552120    Free PMC article.
A Bayesian approach to determine the composition of heterogeneous cancer tissue.
Ashish Katiyar, Anwoy Mohanty, +4 authors, Michael L Bittner.
BMC Bioinformatics, 2018 Mar 29; 19(Suppl 3). PMID: 29589556    Free PMC article.
Validation of [18F]FLT as a perfusion-independent imaging biomarker of tumour response in EGFR-mutated NSCLC patients undergoing treatment with an EGFR tyrosine kinase inhibitor.
R Iqbal, G M Kramer, +4 authors, QuIC-ConCePT Consortium.
EJNMMI Res, 2018 Mar 30; 8(1). PMID: 29594931    Free PMC article.
High-speed Raman-encoded molecular imaging of freshly excised tissue surfaces with topically applied SERRS nanoparticles.
Yu Winston Wang, Qian Yang, +2 authors, Jonathan T C Liu.
J Biomed Opt, 2018 Apr 17; 23(4). PMID: 29658229    Free PMC article.
Precision Medicine with Imprecise Therapy: Computational Modeling for Chemotherapy in Breast Cancer.
Matthew T McKenna, Jared A Weis, +2 authors, Thomas E Yankeelov.
Transl Oncol, 2018 Apr 21; 11(3). PMID: 29674173    Free PMC article.
Review.
Bayesian model selection for complex dynamic systems.
Christoph Mark, Claus Metzner, +3 authors, Ben Fabry.
Nat Commun, 2018 May 08; 9(1). PMID: 29728622    Free PMC article.
A new method of identifying glioblastoma subtypes and creation of corresponding animal models.
Xia Zhou, Gonghua Li, +9 authors, Xudong Zhao.
Oncogene, 2018 May 18; 37(35). PMID: 29769617
Targeted Tumor Therapy Remixed-An Update on the Use of Small-Molecule Drugs in Combination Therapies.
Martina V Gatzka.
Cancers (Basel), 2018 May 26; 10(6). PMID: 29794999    Free PMC article.
Review.
Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypes.
Lan Zhao, Hongya Zhao, Hong Yan.
BMC Cancer, 2018 May 31; 18(1). PMID: 29843660    Free PMC article.
2017 Update on Ovarian Cancer Peritoneal Carcinomatosis Multimodal-Treatment Considerations.
Evgenia Halkia, George Chrelias, Charalambos Chrelias, Jesus Esquivel.
Gastroenterol Res Pract, 2018 Jun 01; 2018. PMID: 29849590    Free PMC article.
Review.
Characterization of tumor heterogeneity by latent haplotypes: a sequential Monte Carlo approach.
Oyetunji E Ogundijo, Xiaodong Wang.
PeerJ, 2018 Jun 06; 6. PMID: 29868266    Free PMC article.
Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways.
Sébastien De Landtsheer, Philippe Lucarelli, Thomas Sauter.
Front Physiol, 2018 Jun 07; 9. PMID: 29872402    Free PMC article.
Live-single-cell phenotypic cancer biomarkers-future role in precision oncology?
Grannum R Sant, Kevin B Knopf, David M Albala.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872705    Free PMC article.
Review.
Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance.
Farzana Ahmed, Nikolas K Haass.
Front Oncol, 2018 Jun 09; 8. PMID: 29881716    Free PMC article.
Highly Cited. Review.
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
So Won Lee, Hyunjin Park, +5 authors, Myung-Ju Ahn.
Sci Rep, 2018 Jun 14; 8(1). PMID: 29895834    Free PMC article.
Single-cell whole-genome sequencing identifies human papillomavirus integration in cervical tumour cells prior to and following radiotherapy.
Dong Yang, Weiyuan Zhang, +7 authors, Jing Chen.
Oncol Lett, 2018 Jun 22; 15(6). PMID: 29928338    Free PMC article.
Liquid biopsy in pancreatic cancer: the beginning of a new era.
Dipesh Kumar Yadav, Xueli Bai, +5 authors, Tingbo Liang.
Oncotarget, 2018 Jun 22; 9(42). PMID: 29928492    Free PMC article.
Review.
Quantification of sarcomatoid differentiation in renal cell carcinoma on magnetic resonance imaging.
Daniel Jeong, Natarajan Raghunand, +4 authors, Jasreman Dhillon.
Quant Imaging Med Surg, 2018 Jun 22; 8(4). PMID: 29928602    Free PMC article.
AN EVOLUTIONARY MODEL OF TUMOR CELL KINETICS AND THE EMERGENCE OF MOLECULAR HETEROGENEITY DRIVING GOMPERTZIAN GROWTH.
Jeffrey West, Zaki Hasnain, Paul Macklin, Paul K Newton.
SIAM Rev Soc Ind Appl Math, 2016 Jan 01; 58(4). PMID: 29937592    Free PMC article.
Deconvolution and phylogeny inference of structural variations in tumor genomic samples.
Jesse Eaton, Jingyi Wang, Russell Schwartz.
Bioinformatics, 2018 Jun 29; 34(13). PMID: 29950001    Free PMC article.
Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept.
Joana Figueiredo, Isabel Rodrigues, +6 authors, João M Sanches.
Sci Rep, 2018 Jul 08; 8(1). PMID: 29980764    Free PMC article.
Engineering cell heterogeneity into organs-on-a-chip.
David R Mertz, Tasdiq Ahmed, Shuichi Takayama.
Lab Chip, 2018 Jul 25; 18(16). PMID: 30040104    Free PMC article.
Review.
Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective.
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi.
J Mol Med (Berl), 2018 Jul 30; 96(9). PMID: 30056527
Review.
Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power.
Javad Noorbakhsh, Hyunsoo Kim, Sandeep Namburi, Jeffrey H Chuang.
Sci Rep, 2018 Aug 01; 8(1). PMID: 30061557    Free PMC article.
Dual-functionality of RASSF1A overexpression in A375 cells is mediated by activation of IL-6/STAT3 regulatory loop.
Mei Yi, Wei Wang, +11 authors, Bo Xiang.
Mol Biol Rep, 2018 Aug 04; 45(5). PMID: 30074127
Meta-analysis of oncologic effect of primary tumor resection in patients with unresectable stage IV colorectal cancer in the era of modern systemic chemotherapy.
Gi Won Ha, Jong Hun Kim, Min Ro Lee.
Ann Surg Treat Res, 2018 Aug 07; 95(2). PMID: 30079322    Free PMC article.
Speciation Theory of Carcinogenesis Explains Karyotypic Individuality and Long Latencies of Cancers.
Ankit Hirpara, Mathew Bloomfield, Peter Duesberg.
Genes (Basel), 2018 Aug 12; 9(8). PMID: 30096943    Free PMC article.
Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization.
K Laxmi Swetha, Aniruddha Roy.
Drug Deliv Transl Res, 2018 Aug 22; 8(5). PMID: 30128797
Review.
Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites.
Sungsik Kim, Soochi Kim, +5 authors, Yong Sang Song.
Sci Rep, 2018 Aug 26; 8(1). PMID: 30143682    Free PMC article.
The detection of primary and secondary EGFR mutations using droplet digital PCR in patients with nonsmall cell lung cancer.
Moushumi Suryavanshi, Anurag Mehta, +10 authors, Dinesh Chandra Doval.
Lung India, 2018 Sep 01; 35(5). PMID: 30168456    Free PMC article.
Novel digital signatures of tissue phenotypes for predicting distant metastasis in colorectal cancer.
Korsuk Sirinukunwattana, David Snead, +5 authors, Nasir Rajpoot.
Sci Rep, 2018 Sep 14; 8(1). PMID: 30209315    Free PMC article.
Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.
Charles E Gast, Alain D Silk, +25 authors, Melissa H Wong.
Sci Adv, 2018 Sep 15; 4(9). PMID: 30214939    Free PMC article.
Highly Cited.
Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer.
Woo Kyung Lee, Seul Gi Lee, +6 authors, Jandee Lee.
Int J Mol Sci, 2018 Sep 23; 19(10). PMID: 30241415    Free PMC article.
Retinoblastoma Intrinsically Regulates Niche Cell Quiescence, Identity, and Niche Number in the Adult Drosophila Testis.
Leah J Greenspan, Erika L Matunis.
Cell Rep, 2018 Sep 27; 24(13). PMID: 30257208    Free PMC article.
Prognostic Value of Tumor Heterogeneity on 18F-FDG PET/CT in HR+HER2- Metastatic Breast Cancer Patients receiving 500 mg Fulvestrant: a retrospective study.
Yannan Zhao, Cheng Liu, +6 authors, Biyun Wang.
Sci Rep, 2018 Sep 29; 8(1). PMID: 30262849    Free PMC article.
Clonal dynamics in osteosarcoma defined by RGB marking.
Stefano Gambera, Ander Abarrategi, +4 authors, Javier García-Castro.
Nat Commun, 2018 Sep 30; 9(1). PMID: 30266933    Free PMC article.
Circulating tumor DNA (ctDNA) in the era of personalized cancer therapy.
Fatemeh Khatami, Seyed Mohammad Tavangar.
J Diabetes Metab Disord, 2018 Oct 06; 17(1). PMID: 30288382    Free PMC article.
Review.
New PET/CT Features for the Evaluation of Tumor Response.
Wei Lu.
J Nucl Med Radiat Ther, 2013 Jan 01; 4(3). PMID: 30310728    Free PMC article.
miR4673 improves fitness profile of neoplastic cells by induction of autophagy.
Kağan Dökümcü, Mary Simonian, Ramin M Farahani.
Cell Death Dis, 2018 Oct 21; 9(11). PMID: 30341280    Free PMC article.
Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivity.
Ganiou Assani, Yudi Xiong, Fuxiang Zhou, Yunfeng Zhou.
Oncotarget, 2018 Nov 09; 9(79). PMID: 30405890    Free PMC article.
Review.
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.
Ankur Sharma, Elaine Yiqun Cao, +15 authors, Ramanuj DasGupta.
Nat Commun, 2018 Nov 24; 9(1). PMID: 30467425    Free PMC article.
Characterizing Trastuzumab-Induced Alterations in Intratumoral Heterogeneity with Quantitative Imaging and Immunohistochemistry in HER2+ Breast Cancer.
Anum K Syed, Ryan Woodall, +2 authors, Anna G Sorace.
Neoplasia, 2018 Nov 26; 21(1). PMID: 30472501    Free PMC article.
Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.
Ada Koschorke, Simona Faraci, +13 authors, Serenella M Pupa.
Cell Oncol (Dordr), 2019 Aug 04; 42(6). PMID: 31376137
CTCF and cellular heterogeneity.
Gang Ren, Keji Zhao.
Cell Biosci, 2019 Oct 22; 9. PMID: 31632638    Free PMC article.
Review.
SpliceHetero: An information theoretic approach for measuring spliceomic intratumor heterogeneity from bulk tumor RNA-seq.
Minsu Kim, Sangseon Lee, Sangsoo Lim, Sun Kim.
PLoS One, 2019 Oct 24; 14(10). PMID: 31644551    Free PMC article.
Differential detachment of intact and viable cells of different sizes using laser-induced microbubbles.
Wanyoung Lim, Seungjin Lee, Sungsu Park, Hyoung Won Baac.
Biomed Opt Express, 2019 Oct 28; 10(10). PMID: 31646019    Free PMC article.
A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.
Yirong Sim, Gwendolene Xin Pei Ng, +17 authors, Puay Hoon Tan.
BMC Med Genomics, 2019 Oct 28; 12(1). PMID: 31647027    Free PMC article.
Prognostic Value of Texture Analysis Based on Pretreatment DWI-Weighted MRI for Esophageal Squamous Cell Carcinoma Patients Treated With Concurrent Chemo-Radiotherapy.
Zhenjiang Li, Chun Han, +3 authors, Baosheng Li.
Front Oncol, 2019 Nov 05; 9. PMID: 31681593    Free PMC article.
Epigenetic heterogeneity in cancer.
Mingzhou Guo, Yaojun Peng, +2 authors, James G Herman.
Biomark Res, 2019 Nov 07; 7. PMID: 31695915    Free PMC article.
Review.
Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment.
Hao-Ran Sun, Shun Wang, +5 authors, Qiong-Zhu Dong.
Front Oncol, 2019 Nov 12; 9. PMID: 31709180    Free PMC article.
Review.
Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models.
Tiffany M Heaster, Bennett A Landman, Melissa C Skala.
Front Oncol, 2019 Nov 19; 9. PMID: 31737571    Free PMC article.
Immunohistochemical and Molecular Features of Melanomas Exhibiting Intratumor and Intertumor Histomorphologic Heterogeneity.
Haider A Mejbel, Sri Krishna C Arudra, +10 authors, Phyu P Aung.
Cancers (Basel), 2019 Nov 07; 11(11). PMID: 31684113    Free PMC article.
Development of Targeted Alpha Particle Therapy for Solid Tumors.
Narges K Tafreshi, Michael L Doligalski, +8 authors, David L Morse.
Molecules, 2019 Nov 30; 24(23). PMID: 31779154    Free PMC article.
Review.
Overcoming Physiological Barriers to Nanoparticle Delivery-Are We There Yet?
Oliver S Thomas, Wilfried Weber.
Front Bioeng Biotechnol, 2020 Jan 11; 7. PMID: 31921819    Free PMC article.
Review.
Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment.
Mohd Rihan, Lakshmi Vineela Nalla, +3 authors, Amit Khairnar.
Cancer Microenviron, 2019 Jun 12; 12(2-3). PMID: 31183810    Free PMC article.
Review.
Revealing tumor heterogeneity of breast cancer by utilizing the linkage between somatic and germline mutations.
Meng Zou, Rui Jin, Kin Fai Au.
Brief Bioinform, 2018 Sep 22; 20(6). PMID: 30239581    Free PMC article.
Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis.
Shiue-Luen Chen, Chong-You Chen, +7 authors, Guan-Yu Chen.
Nanomaterials (Basel), 2019 Dec 11; 9(12). PMID: 31816919    Free PMC article.
Review.
Roles of circRNAs in the tumour microenvironment.
Qiuge Zhang, Weiwei Wang, +5 authors, Zhenqiang Sun.
Mol Cancer, 2020 Jan 25; 19(1). PMID: 31973726    Free PMC article.
Review.
Imaging Phenotypes of Breast Cancer Heterogeneity in Preoperative Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Scans Predict 10-Year Recurrence.
Rhea D Chitalia, Jennifer Rowland, +7 authors, Despina Kontos.
Clin Cancer Res, 2019 Nov 17; 26(4). PMID: 31732521    Free PMC article.
A rare subpopulation of melanoma cells with low expression of metastasis suppressor NME1 is highly metastatic in vivo.
Devin Snyder, Ying Wang, David M Kaetzel.
Sci Rep, 2020 Feb 08; 10(1). PMID: 32029850    Free PMC article.
Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms.
Mark Borris D Aldonza, Jayoung Ku, +11 authors, Yoosik Kim.
Sci Adv, 2020 Feb 23; 6(6). PMID: 32083171    Free PMC article.
Detecting heterogeneity in and between breast cancer cell lines.
Yang Shen, B U Sebastian Schmidt, +4 authors, Wolfgang Losert.
Cancer Converg, 2020 Feb 25; 4(1). PMID: 32090168    Free PMC article.
Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models.
Kathleen Sprouffske, Grainne Kerr, +10 authors, Audrey Kauffmann.
Comput Struct Biotechnol J, 2020 Feb 27; 18. PMID: 32099592    Free PMC article.
Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data.
Sayaka Miura, Tracy Vu, +4 authors, Sudhir Kumar.
Sci Rep, 2020 Feb 28; 10(1). PMID: 32103044    Free PMC article.
Bayesian Framework for Detecting Gene Expression Outliers in Individual Samples.
John Vivian, Jordan M Eizenga, +2 authors, Benedict Paten.
JCO Clin Cancer Inform, 2020 Feb 26; 4. PMID: 32097024    Free PMC article.
Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator.
Bo Young Oh, Hyun-Tae Shin, +13 authors, Woong-Yang Park.
Sci Rep, 2019 Mar 16; 9(1). PMID: 30872730    Free PMC article.
A Fluorescence-Activated Single-Droplet Dispenser for High Accuracy Single-Droplet and Single-Cell Sorting and Dispensing.
Yuling Qin, Li Wu, +8 authors, Daniel T Chiu.
Anal Chem, 2019 May 03; 91(10). PMID: 31050286    Free PMC article.
Circulating Tumor Cell cluster phenotype allows monitoring response to treatment and predicts survival.
Ajay Balakrishnan, Deepak Koppaka, +10 authors, Prashant Kumar.
Sci Rep, 2019 May 30; 9(1). PMID: 31138856    Free PMC article.
Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib in Liver Metastases of Gastrointestinal Stromal Tumors.
Denis Abu Sammour, Christian Marsching, +8 authors, Carsten Hopf.
Sci Rep, 2019 Jul 25; 9(1). PMID: 31337874    Free PMC article.
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Kunihiko Hinohara, Hua-Jun Wu, +25 authors, Kornelia Polyak.
Cancer Cell, 2018 Nov 26; 34(6). PMID: 30472020    Free PMC article.
Prognostic Impact of Intratumoral Heterogeneity Based on Fractal Geometry Analysis in Operated NSCLC Patients.
Angelo Castello, Carlo Russo, +2 authors, Egesta Lopci.
Mol Imaging Biol, 2018 Nov 28; 21(5). PMID: 30478506
Lactic Acid Accumulation in the Tumor Microenvironment Suppresses 18F-FDG Uptake.
Silvan Türkcan, Louise Kiru, +2 authors, Guillem Pratx.
Cancer Res, 2018 Dec 05; 79(2). PMID: 30510121    Free PMC article.
The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling.
Estíbaliz López-Fernández, José I López.
Cancers (Basel), 2018 Dec 07; 10(12). PMID: 30518081    Free PMC article.
Review.
Mechanisms of acquired resistance to afatinib clarified with liquid biopsy.
Tomomi Nakamura, Chiho Nakashima, +4 authors, Naoko Aragane.
PLoS One, 2018 Dec 15; 13(12). PMID: 30550608    Free PMC article.
Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming.
Custodia García-Jiménez, Colin R Goding.
Cell Metab, 2018 Dec 26; 29(2). PMID: 30581118    Free PMC article.
Review.
Resolution of celiac disease, IgA deficiency and platelet refractoriness after allogeneic bone marrow transplantation for acute leukemia.
Sasan Zandi, Solaf Kanfar, +2 authors, Jacob Pendergrast.
Haematologica, 2019 Jan 19; 104(3). PMID: 30655374    Free PMC article.
Cellular interactions constrain tumor growth.
Jeffrey West, Paul K Newton.
Proc Natl Acad Sci U S A, 2019 Jan 25; 116(6). PMID: 30674661    Free PMC article.
A sequential Monte Carlo algorithm for inference of subclonal structure in cancer.
Oyetunji E Ogundijo, Kaiyi Zhu, Xiaodong Wang, Dimitris Anastassiou.
PLoS One, 2019 Jan 27; 14(1). PMID: 30682127    Free PMC article.
The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma.
Xue Bai, Zhenzhen Liu, +7 authors, Chunyan Li.
PLoS One, 2019 Feb 06; 14(2). PMID: 30721267    Free PMC article.
Haralick texture feature analysis for quantifying radiation response heterogeneity in murine models observed using Raman spectroscopic mapping.
Irene Vrbik, Samantha J Van Nest, +4 authors, Andrew Jirasek.
PLoS One, 2019 Feb 16; 14(2). PMID: 30768630    Free PMC article.
Deep learning in head & neck cancer outcome prediction.
André Diamant, Avishek Chatterjee, +2 authors, Jan Seuntjens.
Sci Rep, 2019 Feb 28; 9(1). PMID: 30809047    Free PMC article.
Emerging therapies for non-small cell lung cancer.
Chao Zhang, Natasha B Leighl, Yi-Long Wu, Wen-Zhao Zhong.
J Hematol Oncol, 2019 Apr 27; 12(1). PMID: 31023335    Free PMC article.
Highly Cited. Review.
Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases.
Tania Mamdouhi, Julianne D Twomey, K Melodi McSweeney, Baolin Zhang.
Cancer Metastasis Rev, 2019 May 06; 38(1-2). PMID: 31053984    Free PMC article.
Review.
Hypoxia-induced secretion stimulates breast cancer stem cell regulatory signalling pathways.
Hanna Jacobsson, Hannah Harrison, +9 authors, Göran Landberg.
Mol Oncol, 2019 May 09; 13(8). PMID: 31066211    Free PMC article.
Revealing hemodynamic heterogeneity of gliomas based on signal profile features of dynamic susceptibility contrast-enhanced MRI.
Bing Ji, Silun Wang, +5 authors, Hui Mao.
Neuroimage Clin, 2019 Jun 10; 23. PMID: 31176951    Free PMC article.
Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model.
Mahua Roy, Stacey D Finley.
PLoS Comput Biol, 2019 Jun 12; 15(6). PMID: 31185009    Free PMC article.
Assessment of intratumoral heterogeneity with mutations and gene expression profiles.
Ji-Yong Sung, Hyun-Tae Shin, +3 authors, Je-Gun Joung.
PLoS One, 2019 Jul 17; 14(7). PMID: 31310640    Free PMC article.
Is cell migration a selectable trait in the natural evolution of cancer development?
Andrea Disanza, Sara Bisi, +5 authors, Giorgio Scita.
Philos Trans R Soc Lond B Biol Sci, 2019 Aug 23; 374(1779). PMID: 31431177    Free PMC article.
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer.
Morgan Craig, Kamran Kaveh, +10 authors, Aaron Goldman.
PLoS Comput Biol, 2019 Aug 27; 15(8). PMID: 31449515    Free PMC article.
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.
Gwen Lomberk, Nelson Dusetti, Juan Iovanna, Raul Urrutia.
Nat Commun, 2019 Aug 30; 10(1). PMID: 31462645    Free PMC article.
Review.
Surgical stress and cancer progression: the twisted tango.
Zhiwei Chen, Peidong Zhang, +8 authors, Shengtao Zhou.
Mol Cancer, 2019 Sep 04; 18(1). PMID: 31477121    Free PMC article.
Review.
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors.
L Wan, C A Neumann, P R LeDuc.
Lab Chip, 2020 Feb 07; 20(5). PMID: 32025687    Free PMC article.
Review.
Evaluation of contrast agent dose and diffusion coefficient measurement on vessel size index estimation.
Behrouz Vejdani Afkham, Sadegh Masjoodi, +6 authors, Hasan Hashemi.
MAGMA, 2019 Jul 05; 32(5). PMID: 31270714
Role of texture analysis in breast MRI as a cancer biomarker: A review.
Rhea D Chitalia, Despina Kontos.
J Magn Reson Imaging, 2018 Nov 06; 49(4). PMID: 30390383    Free PMC article.
Review.
Dependence of fluorodeoxyglucose (FDG) uptake on cell cycle and dry mass: a single-cell study using a multi-modal radiography platform.
Yongjin Sung, Marc-Andre Tetrault, +4 authors, Marc D Normandin.
Sci Rep, 2020 Mar 11; 10(1). PMID: 32152343    Free PMC article.
Prognostic Significance of Somatostatin Receptor Heterogeneity in Progressive Neuroendocrine Tumor Treated with Lu-177 DOTATOC or Lu-177 DOTATATE.
Josephine Graf, Ulrich-Frank Pape, +5 authors, Vikas Prasad.
Eur J Nucl Med Mol Imaging, 2019 Aug 16; 47(4). PMID: 31414209
PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer.
Gianluca Lopez, Marianna Noale, +12 authors, Nicola Fusco.
Int J Mol Sci, 2020 Feb 27; 21(4). PMID: 32098071    Free PMC article.
Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells under Stress Condition.
Kai-Chih Huang, Junjie Li, +2 authors, Ji-Xin Cheng.
iScience, 2020 Mar 18; 23(3). PMID: 32179477    Free PMC article.
A review on tumor heterogeneity and evolution in multiple myeloma: pathological, radiological, molecular genetics, and clinical integration.
Christian M Schürch, Leo Rasche, +2 authors, Falko Fend.
Virchows Arch, 2019 Dec 19; 476(3). PMID: 31848687
Review.
Added value of mean and entropy of apparent diffusion coefficient values for evaluating histologic phenotypes of invasive ductal breast cancer with MR imaging.
Shiteng Suo, Dandan Zhang, +4 authors, Jianrong Xu.
Eur Radiol, 2018 Aug 18; 29(3). PMID: 30116958
CT texture analysis of pancreatic cancer.
Kumar Sandrasegaran, Yuning Lin, +2 authors, Mark Tann.
Eur Radiol, 2018 Aug 18; 29(3). PMID: 30116961
Intratumoral Heterogeneity: More Than Just Mutations.
Kunihiko Hinohara, Kornelia Polyak.
Trends Cell Biol, 2019 Apr 17; 29(7). PMID: 30987806    Free PMC article.
Highly Cited. Review.
Tracking tumor evolution one-cell-at-a-time.
Ankur Sharma, Ramanuj DasGupta.
Mol Cell Oncol, 2019 May 28; 6(3). PMID: 31131309    Free PMC article.
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.
Yurena Vivas-García, Paola Falletta, +13 authors, Colin R Goding.
Mol Cell, 2019 Nov 18; 77(1). PMID: 31733993    Free PMC article.
The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations.
Andrei Buruiană, Ștefan Ioan Florian, +8 authors, Sergiu Șușman.
Int J Mol Sci, 2020 Mar 18; 21(6). PMID: 32178454    Free PMC article.
Review.
Mathematical modeling of tumor-immune cell interactions.
Grace E Mahlbacher, Kara C Reihmer, Hermann B Frieboes.
J Theor Biol, 2019 Mar 06; 469. PMID: 30836073    Free PMC article.
Review.
Human Colon Organoids and Other Laboratory Strategies to Enhance Patient Treatment Selection.
Katherine A Johnson, Rebecca A DeStefanis, +5 authors, Dustin A Deming.
Curr Treat Options Oncol, 2020 Apr 25; 21(5). PMID: 32328818    Free PMC article.
Review.
Discriminating different grades of cervical intraepithelial neoplasia based on label-free phasor fluorescence lifetime imaging microscopy.
Xinyi Wang, Yulan Wang, +4 authors, Lan Mi.
Biomed Opt Express, 2020 Apr 29; 11(4). PMID: 32341861    Free PMC article.
Co-expression of key gene modules and pathways of human breast cancer cell lines.
Yadong Wu, Feng Liu, +5 authors, Jukun Song.
Biosci Rep, 2019 Jul 10; 39(7). PMID: 31285391    Free PMC article.
Tumor Copy Number Deconvolution Integrating Bulk and Single-Cell Sequencing Data.
Haoyun Lei, Bochuan Lyu, +8 authors, Russell Schwartz.
J Comput Biol, 2020 Mar 18; 27(4). PMID: 32181683    Free PMC article.
Texture Analysis of Breast DCE-MRI Based on Intratumoral Subregions for Predicting HER2 2+ Status.
Hecheng Lu, Jiandong Yin.
Front Oncol, 2020 May 07; 10. PMID: 32373531    Free PMC article.
Identification of Pancreaticoduodenectomy Resection for Pancreatic Head Adenocarcinoma: A Preliminary Study of Radiomics.
Bei Hui, Jia-Jun Qiu, Jin-Heng Liu, Neng-Wen Ke.
Comput Math Methods Med, 2020 May 08; 2020. PMID: 32377222    Free PMC article.
Optimizing adaptive cancer therapy: dynamic programming and evolutionary game theory.
Mark Gluzman, Jacob G Scott, Alexander Vladimirsky.
Proc Biol Sci, 2020 Apr 22; 287(1925). PMID: 32315588    Free PMC article.
Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding.
Yana K Reshetnyak, Anna Moshnikova, Oleg A Andreev, Donald M Engelman.
Front Bioeng Biotechnol, 2020 May 16; 8. PMID: 32411684    Free PMC article.
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Estimating the predictability of cancer evolution.
Sayed-Rzgar Hosseini, Ramon Diaz-Uriarte, Florian Markowetz, Niko Beerenwinkel.
Bioinformatics, 2019 Sep 13; 35(14). PMID: 31510665    Free PMC article.
Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK.
Nurbubu T Moldogazieva, Innokenty M Mokhosoev, Alexander A Terentiev.
Cancers (Basel), 2020 Apr 08; 12(4). PMID: 32252351    Free PMC article.
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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.
Yuning J Tang, Jianguo Huang, +13 authors, Benjamin A Alman.
Cell Rep, 2019 Sep 12; 28(11). PMID: 31509746    Free PMC article.
Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer.
Kenneth J Pienta, Emma U Hammarlund, +2 authors, Joel S Brown.
Mol Cancer Res, 2020 Apr 03; 18(6). PMID: 32234827    Free PMC article.
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Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment.
Joe T Sharick, Christine M Walsh, +14 authors, Melissa C Skala.
Front Oncol, 2020 Jun 06; 10. PMID: 32500020    Free PMC article.
DAMEfinder: a method to detect differential allele-specific methylation.
Stephany Orjuela, Dania Machlab, +2 authors, Mark D Robinson.
Epigenetics Chromatin, 2020 Jun 04; 13(1). PMID: 32487212    Free PMC article.
Role of the mitochondrial stress response in human cancer progression.
Sheng-Fan Wang, Shiuan Chen, Ling-Ming Tseng, Hsin-Chen Lee.
Exp Biol Med (Maywood), 2020 Apr 25; 245(10). PMID: 32326760    Free PMC article.
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Lack of Association Between Radiographic Tumor Burden and Efficacy of Immune Checkpoint Inhibitors in Advanced Lung Cancer.
Vinita Popat, Rong Lu, +3 authors, David E Gerber.
Oncologist, 2020 Apr 02; 25(6). PMID: 32233048    Free PMC article.
Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response.
Damien J McHugh, Grazyna Lipowska-Bhalla, +9 authors, Geoffrey J M Parker.
Magn Reson Med, 2020 Feb 15; 84(3). PMID: 32057115    Free PMC article.
Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective.
Teresa W-M Fan, Richard M Higashi, Yelena Chernayavskaya, Andrew N Lane.
Metabolites, 2020 Jun 19; 10(6). PMID: 32549391    Free PMC article.
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Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.
Leonard A Harris, Samantha Beik, +2 authors, Alissa M Weaver.
Curr Opin Syst Biol, 2020 Jul 10; 17. PMID: 32642602    Free PMC article.
Multiparametric Analysis of Longitudinal Quantitative MRI data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer.
Anum K Syed, Jennifer G Whisenant, +2 authors, Thomas E Yankeelov.
Cancers (Basel), 2020 Jul 01; 12(6). PMID: 32599906    Free PMC article.
Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician's Point of View.
Roberto Gasparri, Giulia Sedda, Lorenzo Spaggiari.
J Clin Med, 2020 Jun 13; 9(6). PMID: 32526831    Free PMC article.
Reciprocal Reprogramming of Cancer Cells and Associated Mesenchymal Stem Cells in Gastric Cancer.
Yeela Shamai, Dalia Cohn Alperovich, +2 authors, Maty Tzukerman.
Stem Cells, 2018 Nov 01; 37(2). PMID: 30379370    Free PMC article.
DEBay: A computational tool for deconvolution of quantitative PCR data for estimation of cell type-specific gene expression in a mixed population.
Vimalathithan Devaraj, Biplab Bose.
Heliyon, 2020 Jul 31; 6(7). PMID: 32728643    Free PMC article.
An interventional image-guided microdevice implantation and retrieval method for in-vivo drug response assessment.
Sharath K Bhagavatula, Kunj Upadhyaya, +5 authors, Oliver Jonas.
Med Phys, 2019 Sep 09; 46(11). PMID: 31494942    Free PMC article.
Radiation-induced bystander and abscopal effects: important lessons from preclinical models.
Elisabeth Daguenet, Safa Louati, +6 authors, Nicolas Magné.
Br J Cancer, 2020 Jun 26; 123(3). PMID: 32581341    Free PMC article.
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Hypoxic colorectal cancer cells promote metastasis of normoxic cancer cells depending on IL-8/p65 signaling pathway.
Yulong Mi, Lei Mu, +7 authors, Jichao Qin.
Cell Death Dis, 2020 Aug 02; 11(7). PMID: 32737283    Free PMC article.
Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting.
Joana Vieira de Castro, Céline S Gonçalves, Adília Hormigo, Bruno M Costa.
Int J Mol Sci, 2020 Jul 30; 21(15). PMID: 32722427    Free PMC article.
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Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning.
Johanna Gesperger, Antonia Lichtenegger, +10 authors, Adelheid Woehrer.
Cancers (Basel), 2020 Jul 10; 12(7). PMID: 32640583    Free PMC article.
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor.
Xun Xu, Yong Hou, +36 authors, Jun Wang.
Cell, 2012 Mar 06; 148(5). PMID: 22385958    Free PMC article.
Highly Cited.
Genomic comparison of paired primary breast carcinomas and lymph node macrometastases using the Oncotype DX Breast Recurrence Score® test.
Susan K Boolbol, Manju Harshan, +8 authors, Stephen Malamud.
Breast Cancer Res Treat, 2019 Jul 16; 177(3). PMID: 31302854    Free PMC article.
Biological and Medical Importance of Cellular Heterogeneity Deciphered by Single-Cell RNA Sequencing.
Rishikesh Kumar Gupta, Jacek Kuznicki.
Cells, 2020 Jul 28; 9(8). PMID: 32707839    Free PMC article.
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Eco-oncology: Applying ecological principles to understand and manage cancer.
Brent A Reynolds, Monika W Oli, Madan K Oli.
Ecol Evol, 2020 Sep 05; 10(16). PMID: 32884638    Free PMC article.
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Circulating Tumor DNA in Biliary Tract Cancer: Current Evidence and Future Perspectives.
Alessandro Rizzo, Angela Dalia Ricci, Simona Tavolari, Giovanni Brandi.
Cancer Genomics Proteomics, 2020 Aug 30; 17(5). PMID: 32859625    Free PMC article.
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Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer.
Christian Arstad, Kristin Taskén, +3 authors, Per Olaf Ekstrøm.
Prostate Cancer, 2020 Sep 11; 2020. PMID: 32908706    Free PMC article.
Gene expression-based clinical predictions in lung adenocarcinoma.
Yanlu Xiong, Jie Lei, +5 authors, Yong Han.
Aging (Albany NY), 2020 Aug 07; 12(15). PMID: 32756002    Free PMC article.
Predictive value of quantitative 18F-FDG-PET radiomics analysis in patients with head and neck squamous cell carcinoma.
Roland M Martens, Thomas Koopman, +14 authors, Ronald Boellaard.
EJNMMI Res, 2020 Sep 08; 10(1). PMID: 32894373    Free PMC article.
Treatment for non-small-cell lung cancer and circulating tumor cells.
Joel Mason, Benjamin Blyth, Michael P MacManus, Olga A Martin.
Lung Cancer Manag, 2019 Jan 16; 6(4). PMID: 30643579    Free PMC article.
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The Role of SVZ Stem Cells in Glioblastoma.
Christine Altmann, Stefanie Keller, Mirko H H Schmidt.
Cancers (Basel), 2019 Apr 03; 11(4). PMID: 30934929    Free PMC article.
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Activated Charge-Reversal Polymeric Nano-System: The Promising Strategy in Drug Delivery for Cancer Therapy.
Yichen Hu, Xiao Gong, +5 authors, Gang Zhao.
Polymers (Basel), 2016 Apr 05; 8(4). PMID: 30979214    Free PMC article.
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The Potential Use of DCE-MRI Texture Analysis to Predict HER2 2+ Status.
Zejun Jiang, Lirong Song, Hecheng Lu, Jiandong Yin.
Front Oncol, 2019 Apr 30; 9. PMID: 31032222    Free PMC article.
Contribution of Epithelial Plasticity to Therapy Resistance.
Patricia G Santamaría, Gema Moreno-Bueno, Amparo Cano.
J Clin Med, 2019 May 17; 8(5). PMID: 31091749    Free PMC article.
Highly Cited. Review.
Diagnosis of Mixed Adenoneuroendocrine Carcinoma (MANEC) after Neoadjuvant Chemotherapy for Pancreatic and Gastric Adenocarcinoma: Two Case Reports and a Review of the Literature.
Ester Oneda, Barbara Liserre, +4 authors, Alberto Zaniboni.
Case Rep Oncol, 2019 Jul 06; 12(2). PMID: 31275134    Free PMC article.
Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate.
Saveg Yadav, Shrish Kumar Pandey, +2 authors, Sukh Mahendra Singh.
Front Pharmacol, 2019 Jul 25; 10. PMID: 31333455    Free PMC article.
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Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability.
Nicola Fusco, Gianluca Lopez, +13 authors, Silvano Bosari.
JNCI Cancer Spectr, 2019 Jul 31; 2(4). PMID: 31360876    Free PMC article.
Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma.
Lehang Lin, De-Chen Lin.
Cancers (Basel), 2019 Aug 15; 11(8). PMID: 31409002    Free PMC article.
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First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma.
Maxine Tran, Arash Latifoltojar, +23 authors, Shonit Punwani.
BJR Case Rep, 2019 Aug 21; 5(3). PMID: 31428445    Free PMC article.
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution.
Ankur Sharma.
Epigenet Insights, 2019 Aug 28; 12. PMID: 31453434    Free PMC article.
PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism.
Daniel Ehrsam, Fabiola Porta, +2 authors, Henriette E Meyer Zu Schwabedissen.
Materials (Basel), 2019 Sep 06; 12(17). PMID: 31484396    Free PMC article.
Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis.
Mathieu Giraudeau, Tuul Sepp, +5 authors, Frédéric Thomas.
Evol Med Public Health, 2019 Sep 19; 2019(1). PMID: 31528343    Free PMC article.
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Characterization of Ablation Thresholds for 3D-Cultured Patient-Derived Glioma Stem Cells in Response to High-Frequency Irreversible Electroporation.
J W Ivey, E M Wasson, +5 authors, S S Verbridge.
Research (Wash D C), 2019 Sep 25; 2019. PMID: 31549086    Free PMC article.
Enhancing the efficacy of immunotherapy using radiotherapy.
Synat Keam, Suki Gill, +2 authors, Alistair M Cook.
Clin Transl Immunology, 2020 Oct 01; 9(9). PMID: 32994997    Free PMC article.
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Molecular patterns in the evolution of serrated lesion of the colorectum.
Timo Gaiser, Sandra Meinhardt, +10 authors, Thomas Ried.
Int J Cancer, 2012 Sep 27; 132(8). PMID: 23011871    Free PMC article.
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take.
Patricia Altea-Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah-Maria Fendt.
EMBO Rep, 2020 Sep 24; 21(10). PMID: 32964587    Free PMC article.
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Modeling How Heterogeneity in Cell Cycle Length Affects Cancer Cell Growth Dynamics in Response to Treatment.
Eleftheria Tzamali, Georgios Tzedakis, Vangelis Sakkalis.
Front Oncol, 2020 Oct 13; 10. PMID: 33042800    Free PMC article.
COL2A1 Is a Novel Biomarker of Melanoma Tumor Repopulating Cells.
Bhavana Talluri, Kshitij Amar, +5 authors, Farhan Chowdhury.
Biomedicines, 2020 Sep 24; 8(9). PMID: 32962144    Free PMC article.
Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.
Mingxuan Li, Jiwei Bai, +5 authors, Yazhuo Zhang.
BMC Cancer, 2020 Oct 14; 20(1). PMID: 33046024    Free PMC article.
Accuracy and reproducibility of somatic point mutation calling in clinical-type targeted sequencing data.
Ali Karimnezhad, Gareth A Palidwor, +4 authors, Theodore J Perkins.
BMC Med Genomics, 2020 Oct 17; 13(1). PMID: 33059707    Free PMC article.
Biomedical Application of Reactive Oxygen Species-Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases.
Jinggong Liu, Yongjin Li, +4 authors, Tianfeng Chen.
Front Chem, 2020 Oct 17; 8. PMID: 33062637    Free PMC article.
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Metabolic Constrains Rule Metastasis Progression.
Niccolo' Roda, Valentina Gambino, Marco Giorgio.
Cells, 2020 Sep 17; 9(9). PMID: 32932943    Free PMC article.
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Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy.
Pei Zhang, Qin Xia, +2 authors, Lei Dong.
Front Mol Biosci, 2020 Oct 27; 7. PMID: 33102518    Free PMC article.
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Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.
Yen-Chun Huang, Hsiao-Huang Chang, +5 authors, Wen-Liang Fang.
Medicine (Baltimore), 2020 Oct 09; 99(41). PMID: 33031286    Free PMC article.
Comparison of Nasopharyngeal MR, 18 F-FDG PET/CT, and 18 F-FDG PET/MR for Local Detection of Natural Killer/T-Cell Lymphoma, Nasal Type.
Rui Guo, Pengpeng Xu, +11 authors, Biao Li.
Front Oncol, 2020 Nov 13; 10. PMID: 33178609    Free PMC article.
Intratumor Heterogeneity of MYO18A and FBXW7 Variants Impact the Clinical Outcome of Stage III Colorectal Cancer.
Peng-Chan Lin, Yu-Min Yeh, +4 authors, Meng-Ru Shen.
Front Oncol, 2020 Nov 17; 10. PMID: 33194745    Free PMC article.
What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
Anna K Miller, Joel S Brown, David Basanta, Nancy Huntly.
Cancer Control, 2020 Jul 30; 27(3). PMID: 32723185    Free PMC article.
Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial.
Nicoletta Castagnino, Massimo Maffei, +7 authors, Silvio Parodi.
Wiley Interdiscip Rev Syst Biol Med, 2016 May 31; 8(4). PMID: 27240214    Free PMC article.
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Gold Nanoparticles in Single-Cell Analysis for Surface Enhanced Raman Scattering.
Mine Altunbek, Gamze Kuku, Mustafa Culha.
Molecules, 2016 Nov 30; 21(12). PMID: 27897986    Free PMC article.
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Characterisation of anticancer peptides at the single-cell level.
L Armbrecht, G Gabernet, +3 authors, P S Dittrich.
Lab Chip, 2017 Jul 25; 17(17). PMID: 28736788    Free PMC article.
A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.
Ana de la Cueva, Michael Emmerling, +4 authors, Kathrin H Kirsch.
Carcinogenesis, 2018 Mar 27; 39(7). PMID: 29579155    Free PMC article.
Integrated analysis of transcription factors and targets co-expression profiles reveals reduced correlation between transcription factors and target genes in cancer.
Jinsheng Liang, Ying Cui, +5 authors, Hongli Du.
Funct Integr Genomics, 2018 Sep 27; 19(1). PMID: 30251028
Comprehensive genetic alteration profiling in primary and recurrent glioblastoma.
Beth K Neilsen, Richard Sleightholm, +6 authors, Michele R Aizenberg.
J Neurooncol, 2018 Dec 12; 142(1). PMID: 30535594
SeqClone: sequential Monte Carlo based inference of tumor subclones.
Oyetunji E Ogundijo, Xiaodong Wang.
BMC Bioinformatics, 2019 Jan 07; 20(1). PMID: 30611189    Free PMC article.
Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids.
Joe T Sharick, Justin J Jeffery, +4 authors, Melissa C Skala.
Neoplasia, 2019 May 12; 21(6). PMID: 31078067    Free PMC article.
Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.
Timo Gemoll, Elena Miroll, +4 authors, Jens K Habermann.
BMC Cancer, 2019 Jul 20; 19(1). PMID: 31319803    Free PMC article.
Photodynamic therapy of cervical cancer by eradication of cervical cancer cells and cervical cancer stem cells.
Elvin Peter Chizenga, Rahul Chandran, Heidi Abrahamse.
Oncotarget, 2019 Jul 20; 10(43). PMID: 31320992    Free PMC article.
Clonal Reconstruction of Thyroid Cancer: An Essential Strategy for Preventing Resistance to Ultra-Precision Therapy.
Elizabeth R McGonagle, Carmelo Nucera.
Front Endocrinol (Lausanne), 2019 Aug 06; 10. PMID: 31379741    Free PMC article.
A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis.
Megan Shand, Jose Soto, +6 authors, Eric Banks.
Commun Biol, 2020 Dec 10; 3(1). PMID: 33293579    Free PMC article.
Mitochondrial oxidative phosphorylation in cutaneous melanoma.
Prakrit R Kumar, Jamie A Moore, +2 authors, Marc D Moncrieff.
Br J Cancer, 2020 Nov 19; 124(1). PMID: 33204029    Free PMC article.
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High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer.
Huu Tuan Nguyen, Daniel Migliozzi, +2 authors, Martin A M Gijs.
Lab Invest, 2019 Jan 20; 99(5). PMID: 30659272    Free PMC article.
The Strange Case of Jekyll and Hyde: Parallels Between Neural Stem Cells and Glioblastoma-Initiating Cells.
David Bakhshinyan, Neil Savage, +2 authors, Sheila K Singh.
Front Oncol, 2021 Jan 26; 10. PMID: 33489908    Free PMC article.
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High heterogeneity undermines generalization of differential expression results in RNA-Seq analysis.
Weitong Cui, Huaru Xue, +3 authors, Qinglu Wang.
Hum Genomics, 2021 Jan 30; 15(1). PMID: 33509298    Free PMC article.
Current methods in translational cancer research.
Michael W Lee, Mihailo Miljanic, +4 authors, Anna Capasso.
Cancer Metastasis Rev, 2020 Sep 16; 40(1). PMID: 32929562    Free PMC article.
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Expression of immune checkpoints on circulating tumor cells in men with metastatic prostate cancer.
Tian Zhang, Anika Agarwal, +13 authors, Andrew J Armstrong.
Biomark Res, 2021 Feb 20; 9(1). PMID: 33602330    Free PMC article.
Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells.
K J Pienta, E U Hammarlund, +2 authors, R M Axelrod.
Proc Natl Acad Sci U S A, 2021 Jan 29; 118(7). PMID: 33504594    Free PMC article.
Neuroblastoma Invasion Strategies Are Regulated by the Extracellular Matrix.
Cian Gavin, Nele Geerts, +5 authors, Olga Piskareva.
Cancers (Basel), 2021 Feb 14; 13(4). PMID: 33578855    Free PMC article.
Immunotherapy of Glioblastoma: Current Strategies and Challenges in Tumor Model Development.
Bernarda Majc, Metka Novak, +2 authors, Barbara Breznik.
Cells, 2021 Feb 13; 10(2). PMID: 33572835    Free PMC article.
Review.
Synthetic Receptor-Based Targeting Strategies to Improve Tumor Drug Delivery.
Susheel Kumar Nethi, Shubhmita Bhatnagar, Swayam Prabha.
AAPS PharmSciTech, 2021 Mar 09; 22(3). PMID: 33683499
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Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry.
Lucia Lisa Petrilli, Federica Riccio, +10 authors, Claudia Fuoco.
J Clin Med, 2021 Mar 07; 10(4). PMID: 33671425    Free PMC article.
Tumor Heterogeneity: A Great Barrier in the Age of Cancer Immunotherapy.
Nader El-Sayes, Alyssa Vito, Karen Mossman.
Cancers (Basel), 2021 Mar 07; 13(4). PMID: 33671881    Free PMC article.
Review.
A Systematic Review of PET Textural Analysis and Radiomics in Cancer.
Manuel Piñeiro-Fiel, Alexis Moscoso, +3 authors, Pablo Aguiar.
Diagnostics (Basel), 2021 Mar 07; 11(2). PMID: 33672285    Free PMC article.
Review.
Concealed driver in lung adenocarcinoma with single PIK3CA mutation: a case report and single-center genotyping review.
Feng Zhu, Jianfu Li, +5 authors, Wenhua Liang.
Ann Transl Med, 2021 Mar 13; 9(3). PMID: 33708898    Free PMC article.
Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation.
Yu Liu, Lili Zou, +3 authors, Jun Wang.
Exp Ther Med, 2021 Mar 19; 21(4). PMID: 33732336    Free PMC article.
Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy.
Chang Shao, Wenjie Lu, Haiping Hao, Hui Ye.
Adv Exp Med Biol, 2021 Apr 02; 1280. PMID: 33791979
Group phenotypic composition in cancer.
Jean-Pascal Capp, James DeGregori, +10 authors, Frédéric Thomas.
Elife, 2021 Mar 31; 10. PMID: 33784238    Free PMC article.
Assessing the contribution of tumor mutational phenotypes to cancer progression risk.
Yifeng Tao, Ashok Rajaraman, +7 authors, Russell Schwartz.
PLoS Comput Biol, 2021 Mar 13; 17(3). PMID: 33711014    Free PMC article.
Inertial Microfluidics Enabling Clinical Research.
Srivathsan Kalyan, Corinna Torabi, +6 authors, Soojung Claire Hur.
Micromachines (Basel), 2021 Apr 04; 12(3). PMID: 33802356    Free PMC article.
Review.
Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery.
Magdalena Jurczyk, Katarzyna Jelonek, +3 authors, Janusz Kasperczyk.
Pharmaceutics, 2021 Apr 04; 13(3). PMID: 33802531    Free PMC article.
Review.
Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway.
Li-Bo Chen, Shun-Ping Zhu, +4 authors, Rong Hu.
Front Oncol, 2021 Apr 13; 11. PMID: 33842334    Free PMC article.