Review
. 2009 Dec; 11(1):7-13.
doi: 10.1038/ni.1818.

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Kajsa Wing 1 Shimon Sakaguchi  
Affiliations
  • PMID: 20016504
  •     99 References
  •     452 citations

Abstract

Immunological self tolerance is maintained at least in part by regulatory T (T(reg)) cells that actively and dominantly control potentially hazardous self-reactive T cells in the periphery. Antigens that stimulate self-reactive T cells may also activate natural T(reg) cells, thereby maintaining dominant self tolerance. Conversely, genetic anomalies or environmental agents that specifically or predominantly affect T(reg) cells cause or predispose to autoimmunity. With recent advances in our understanding of T(reg) cell development in the thymus and periphery and the molecular mechanism of T(reg) cell-mediated suppression, new ways of treating immunological diseases by targeting T(reg) cells at the cellular and molecular levels are envisaged.

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C R Gilson, C M Cadwell, +2 authors, J C Zimring.
Vox Sang, 2010 Jun 16; 99(4). PMID: 20546207    Free PMC article.
Cell-based immunotherapy of prion diseases by adoptive transfer of antigen-loaded dendritic cells or antigen-primed CD(4+) T lymphocytes.
Claude Carnaud, Véronique Bachy.
Prion, 2010 Jul 14; 4(2). PMID: 20622507    Free PMC article.
Dendritic cells: are they clinically relevant?
Karolina Palucka, Hideki Ueno, +2 authors, Jacques Banchereau.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693842    Free PMC article.
Review.
Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.
Brenna L Brady, Michael A Oropallo, +5 authors, Craig H Bassing.
J Immunol, 2010 Aug 17; 185(6). PMID: 20709953    Free PMC article.
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
Daniel Hawiger, Yisong Y Wan, Elizabeth E Eynon, Richard A Flavell.
Nat Immunol, 2010 Aug 31; 11(10). PMID: 20802482    Free PMC article.
TRAIL-expressing CD8+ T cells mediate tolerance following soluble peptide-induced peripheral T cell deletion.
Prajwal Gurung, Tamara A Kucaba, +2 authors, Thomas S Griffith.
J Leukoc Biol, 2010 Sep 03; 88(6). PMID: 20807702    Free PMC article.
The yin and yang of regulatory T cells and inflammation in RA.
Clare A Notley, Michael R Ehrenstein.
Nat Rev Rheumatol, 2010 Sep 03; 6(10). PMID: 20808295
Review.
T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7-/- mice.
Glenda Trujillo, Adam J Hartigan, Cory M Hogaboam.
Fibrogenesis Tissue Repair, 2010 Sep 08; 3. PMID: 20815874    Free PMC article.
Regulatory B cells in autoimmunity: developments and controversies.
Claudia Mauri, Paul A Blair.
Nat Rev Rheumatol, 2010 Sep 22; 6(11). PMID: 20856268
Review.
Antigen receptor allelic exclusion: an update and reappraisal.
Brenna L Brady, Natalie C Steinel, Craig H Bassing.
J Immunol, 2010 Sep 23; 185(7). PMID: 20858891    Free PMC article.
Review.
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.
Marina D Kraaij, Nigel D L Savage, +8 authors, Kyra A Gelderman.
Proc Natl Acad Sci U S A, 2010 Sep 24; 107(41). PMID: 20861446    Free PMC article.
Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog.
Dammy Pinheiro, Yogesh Singh, +10 authors, Oliver A Garden.
Immunology, 2010 Oct 01; 132(1). PMID: 20880379    Free PMC article.
Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis.
Marianne M Martinic, Christoph Huber, +3 authors, Matthias G von Herrath.
J Autoimmun, 2010 Oct 12; 35(4). PMID: 20932718    Free PMC article.
Autoimmunity in Coxsackievirus B3 induced myocarditis: role of estrogen in suppressing autoimmunity.
Future Virol, 2010 Oct 22; 5(3). PMID: 20963181    Free PMC article.
Clues to immune tolerance: the monogenic autoimmune syndromes.
Michael Waterfield, Mark S Anderson.
Ann N Y Acad Sci, 2010 Oct 26; 1214. PMID: 20969580    Free PMC article.
Review.
Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells.
Zhonghua Yan, Sanjay K Garg, Ruma Banerjee.
J Biol Chem, 2010 Nov 03; 285(53). PMID: 21037289    Free PMC article.
Natural regulatory T cells in autoimmunity.
Elaine V Lourenço, Antonio La Cava.
Autoimmunity, 2010 Nov 26; 44(1). PMID: 21091291    Free PMC article.
Review.
Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs.
Yenkel Grinberg-Bleyer, David Saadoun, +11 authors, Benoît L Salomon.
J Clin Invest, 2010 Nov 26; 120(12). PMID: 21099113    Free PMC article.
Foxo: in command of T lymphocyte homeostasis and tolerance.
Weiming Ouyang, Ming O Li.
Trends Immunol, 2010 Nov 26; 32(1). PMID: 21106439    Free PMC article.
Review.
Becoming self-aware: the thymic education of regulatory T cells.
Chan-Wang J Lio, Chyi-Song Hsieh.
Curr Opin Immunol, 2010 Dec 15; 23(2). PMID: 21146972    Free PMC article.
Review.
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes.
Benjamin G Keselowsky, Chang Qing Xia, Michael Clare-Salzler.
Hum Vaccin, 2010 Dec 16; 7(1). PMID: 21157186    Free PMC article.
Review.
Dendritic cells and immunity against cancer.
K Palucka, H Ueno, J Fay, J Banchereau.
J Intern Med, 2010 Dec 17; 269(1). PMID: 21158979    Free PMC article.
Review.
Foxo transcription factors control regulatory T cell development and function.
Yann M Kerdiles, Erica L Stone, +6 authors, Stephen M Hedrick.
Immunity, 2010 Dec 21; 33(6). PMID: 21167754    Free PMC article.
Highly Cited.
Natural and expanded CD4(+)CD25(+) regulatory T cells in bone marrow transplantation.
Lucrezia Colonna, Emanuela I Sega, Robert S Negrin.
Biol Blood Marrow Transplant, 2011 Jan 14; 17(1 Suppl). PMID: 21195311    Free PMC article.
Review.
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.
Thomas Krausgruber, Katrina Blazek, +6 authors, Irina A Udalova.
Nat Immunol, 2011 Jan 18; 12(3). PMID: 21240265
Highly Cited.
Chronic lymphocytic leukemia and autoimmunity: a systematic review.
Kate Hodgson, Gerardo Ferrer, Emili Montserrat, Carol Moreno.
Haematologica, 2011 Jan 19; 96(5). PMID: 21242190    Free PMC article.
Systematic Review.
Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1).
Martin Vaeth, Tea Gogishvili, +10 authors, Josef Bodor.
Proc Natl Acad Sci U S A, 2011 Jan 26; 108(6). PMID: 21262800    Free PMC article.
2011: the immune hallmarks of cancer.
Federica Cavallo, Carla De Giovanni, +2 authors, Pier-Luigi Lollini.
Cancer Immunol Immunother, 2011 Jan 27; 60(3). PMID: 21267721    Free PMC article.
Highly Cited.
Prognostic significance of autoimmunity during treatment of melanoma with interferon.
Michal T Krauze, Ahmad Tarhini, Helen Gogas, John M Kirkwood.
Semin Immunopathol, 2011 Feb 01; 33(4). PMID: 21279809    Free PMC article.
Review.
Thymoma and autoimmunity.
Shahar Shelly, Nancy Agmon-Levin, Arie Altman, Yehuda Shoenfeld.
Cell Mol Immunol, 2011 Feb 15; 8(3). PMID: 21317916    Free PMC article.
Review.
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
Stephanie M Stanford, Divya Krishnamurthy, +14 authors, Nunzio Bottini.
J Med Chem, 2011 Feb 24; 54(6). PMID: 21341673    Free PMC article.
Bcl-2-regulated cell death signalling in the prevention of autoimmunity.
D Tischner, C Woess, E Ottina, A Villunger.
Cell Death Dis, 2011 Mar 03; 1. PMID: 21364654    Free PMC article.
Review.
Quantitative events determine the differentiation and function of helper T cells.
Anne O'Garra, Leona Gabryšová, Hergen Spits.
Nat Immunol, 2011 Mar 23; 12(4). PMID: 21423225
The yin and yang of signaling in Tregs and TH17 cells.
Fan Pan, Huimin Fan, +2 authors, Shuiping Jiang.
Sci Signal, 2011 Mar 24; 4(165). PMID: 21427407    Free PMC article.
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.
Edwin F de Zoeten, Liqing Wang, +8 authors, Wayne W Hancock.
Mol Cell Biol, 2011 Mar 30; 31(10). PMID: 21444725    Free PMC article.
Highly Cited.
Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis.
Alessandro S Farias, Rafael L Talaisys, +5 authors, Fabio T M Costa.
PLoS One, 2011 Apr 06; 6(3). PMID: 21464982    Free PMC article.
Control of central and peripheral tolerance by Aire.
Todd C Metzger, Mark S Anderson.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488892    Free PMC article.
Review.
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Hélène Bour-Jordan, Jonathan H Esensten, +3 authors, Jeffrey A Bluestone.
Immunol Rev, 2011 Apr 15; 241(1). PMID: 21488898    Free PMC article.
Highly Cited. Review.
TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40.
Ryoko Hamano, Jiaqiang Huang, +2 authors, Xin Chen.
Eur J Immunol, 2011 Apr 15; 41(7). PMID: 21491419    Free PMC article.
Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.
Karen Wheeler, Steve Tardif, +7 authors, Kenneth S K Tung.
Proc Natl Acad Sci U S A, 2011 Apr 20; 108(18). PMID: 21502500    Free PMC article.
Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Hans-Joachim Paust, Annett Ostmann, +6 authors, Gisa Tiegs.
Kidney Int, 2011 Apr 29; 80(2). PMID: 21525855    Free PMC article.
CD8α⁺ dendritic cells improve collagen-induced arthritis in CC chemokine receptor (CCR)-2 deficient mice.
Jessica M Ibarra, Marlon P Quinones, +3 authors, Seema S Ahuja.
Immunobiology, 2011 May 03; 216(9). PMID: 21531476    Free PMC article.
Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.
Amy Beres, Richard Komorowski, Masahiko Mihara, William R Drobyski.
Clin Cancer Res, 2011 May 12; 17(12). PMID: 21558402    Free PMC article.
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
Todd V Brennan, Qizhi Tang, +4 authors, Sang-Mo Kang.
J Surg Res, 2011 May 17; 169(1). PMID: 21571317    Free PMC article.
Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity.
Sheng Xia, Haibo Sha, +3 authors, Ling Qi.
J Biol Chem, 2011 May 20; 286(26). PMID: 21592961    Free PMC article.
Costimulatory pathways in transplantation.
Nina Pilat, Mohamed H Sayegh, Thomas Wekerle.
Semin Immunol, 2011 May 28; 23(4). PMID: 21616680    Free PMC article.
A role for IL-27 in limiting T regulatory cell populations.
Elia D Tait Wojno, Nancy Hosken, +6 authors, Christopher A Hunter.
J Immunol, 2011 May 31; 187(1). PMID: 21622862    Free PMC article.
Defective differentiation of regulatory FoxP3+ T cells by small-intestinal dendritic cells in patients with type 1 diabetes.
Ester Badami, Chiara Sorini, +8 authors, Marika Falcone.
Diabetes, 2011 Jun 08; 60(8). PMID: 21646390    Free PMC article.
Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia.
Elena Maganto-García, Margarite L Tarrio, +2 authors, Andrew H Lichtman.
Circulation, 2011 Jun 22; 124(2). PMID: 21690490    Free PMC article.
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.
Angela Hughson, Irina Bromberg, +3 authors, Deborah J Fowell.
Diabetes, 2011 Jul 01; 60(8). PMID: 21715555    Free PMC article.
IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization.
Cheng-Rui Li, Mia F Deiro, Elana Godebu, Linda M Bradley.
J Autoimmun, 2011 Jul 13; 37(3). PMID: 21745722    Free PMC article.
Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells.
Priyanka Nair, Derk Amsen, J Magarian Blander.
Traffic, 2011 Jul 19; 12(12). PMID: 21762455    Free PMC article.
Review.
Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Erin L Collins, Lindsey D Jager, +6 authors, Joseph Larkin.
J Immunol, 2011 Jul 27; 187(5). PMID: 21788442    Free PMC article.
Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells.
James M Ertelt, Jared H Rowe, +4 authors, Sing Sing Way.
J Immunol, 2011 Aug 04; 187(5). PMID: 21810602    Free PMC article.
Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease.
Jeffrey Vanvalkenburgh, Diana I Albu, +10 authors, Dorina Avram.
J Exp Med, 2011 Aug 31; 208(10). PMID: 21875956    Free PMC article.
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes.
Alessandra Ferraro, Carlo Socci, +11 authors, Manuela Battaglia.
Diabetes, 2011 Sep 08; 60(11). PMID: 21896932    Free PMC article.
Highly Cited.
Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.
Savita Nair, Wibke Bayer, +3 authors, Ulf Dittmer.
Retrovirology, 2011 Sep 29; 8. PMID: 21943070    Free PMC article.
Review.
Suppressive role of hepatic dendritic cells in concanavalin A-induced hepatitis.
C Tomiyama, H Watanabe, +2 authors, T Abo.
Clin Exp Immunol, 2011 Oct 12; 166(2). PMID: 21985372    Free PMC article.
Regulatory T cells protect from autoimmune arthritis during pregnancy.
Alba Munoz-Suano, Marinos Kallikourdis, Milka Sarris, Alexander G Betz.
J Autoimmun, 2011 Oct 19; 38(2-3). PMID: 22004905    Free PMC article.
Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10.
Dorothy K Sojka, Deborah J Fowell.
Proc Natl Acad Sci U S A, 2011 Oct 26; 108(45). PMID: 22025707    Free PMC article.
Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells.
Min Chen, Kumar Felix, Jin Wang.
J Immunol, 2011 Oct 28; 187(11). PMID: 22031758    Free PMC article.
T-cell activation and transplantation tolerance.
Bhavana Priyadharshini, Dale L Greiner, Michael A Brehm.
Transplant Rev (Orlando), 2011 Nov 15; 26(3). PMID: 22074786    Free PMC article.
Review.
TLR-dependent T cell activation in autoimmunity.
Kingston H G Mills.
Nat Rev Immunol, 2011 Nov 19; 11(12). PMID: 22094985
Highly Cited. Review.
Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.
Cheng-Rui Li, Bas J G Baaten, Linda M Bradley.
J Mol Cell Biol, 2011 Nov 26; 4(1). PMID: 22116888    Free PMC article.
Review.
Regulatory T cells essential to prevent the loss of self-tolerance in murine models of erythrocyte-specific autoantibody responses.
Catherine E Calkins.
Immunol Res, 2011 Dec 02; 51(2-3). PMID: 22131153
Review.
Can maternal microchimeric cells influence the fetal response toward self antigens?
Lucie Leveque, Kiarash Khosrotehrani.
Chimerism, 2011 Dec 14; 2(3). PMID: 22163064    Free PMC article.
Diagnosis and treatment of autoimmune hepatitis.
John M Vierling.
Curr Gastroenterol Rep, 2011 Dec 20; 14(1). PMID: 22179843
Review.
Gene and cell therapy based treatment strategies for inflammatory bowel diseases.
Sander van der Marel, Anna Majowicz, +3 authors, Valerie Ferreira.
World J Gastrointest Pathophysiol, 2011 Dec 20; 2(6). PMID: 22180846    Free PMC article.
Foxp3(+) regulatory T cells, immune stimulation and host defence against infection.
Jared H Rowe, James M Ertelt, Sing Sing Way.
Immunology, 2012 Jan 04; 136(1). PMID: 22211994    Free PMC article.
Review.
Re-establishing immunological self-tolerance in autoimmune disease.
Shimon Sakaguchi, Fiona Powrie, Richard M Ransohoff.
Nat Med, 2012 Jan 10; 18(1). PMID: 22227673
Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.
Denise Tischner, Irene Gaggl, +6 authors, G Jan Wiegers.
J Autoimmun, 2012 Jan 20; 38(1). PMID: 22257939    Free PMC article.
TSLP and immune homeostasis.
Shino Hanabuchi, Norihiko Watanabe, Yong-Jun Liu.
Allergol Int, 2012 Jan 25; 61(1). PMID: 22270070    Free PMC article.
Review.
Dendritic cells with TGF-β1 and IL-2 differentiate naive CD4+ T cells into alloantigen-specific and allograft protective Foxp3+ regulatory T cells.
Hua Yang, Elaine Y Cheng, +6 authors, Manikkam Suthanthiran.
Transplantation, 2012 Jan 25; 93(6). PMID: 22270834    Free PMC article.
Selection of regulatory T cells in the thymus.
Chyi-Song Hsieh, Hyang-Mi Lee, Chan-Wang J Lio.
Nat Rev Immunol, 2012 Feb 11; 12(3). PMID: 22322317
Highly Cited. Review.
Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells.
D Tischner, G J Wiegers, +2 authors, A Villunger.
Cell Death Differ, 2012 Feb 11; 19(8). PMID: 22322859    Free PMC article.
Clinical immunology.
J David M Edgar.
Ulster Med J, 2012 Feb 22; 80(1). PMID: 22347733    Free PMC article.
Review.
Unmasking the immune recognition of prostate cancer with CTLA4 blockade.
Serena S Kwek, Edward Cha, Lawrence Fong.
Nat Rev Cancer, 2012 Mar 02; 12(4). PMID: 22378189    Free PMC article.
Review.
Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.
Hisako Kayama, Yoshiyasu Ueda, +10 authors, Kiyoshi Takeda.
Proc Natl Acad Sci U S A, 2012 Mar 10; 109(13). PMID: 22403066    Free PMC article.
Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells.
J Magarian Blander, Miriam B Torchinsky, Laura Campisi.
Immunol Res, 2012 Mar 31; 54(1-3). PMID: 22460741    Free PMC article.
Review.
The transition of acute to chronic bowel inflammation in spondyloarthritis.
Liesbet Van Praet, Peggy Jacques, Filip Van den Bosch, Dirk Elewaut.
Nat Rev Rheumatol, 2012 Apr 18; 8(5). PMID: 22508429
Review.
Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.
Xin Yao, Mojgan Ahmadzadeh, +7 authors, Paul F Robbins.
Blood, 2012 May 05; 119(24). PMID: 22555974    Free PMC article.
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells.
Julien Seneschal, Rachael A Clark, +2 authors, Thomas S Kupper.
Immunity, 2012 May 09; 36(5). PMID: 22560445    Free PMC article.
Highly Cited.
Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis.
Yu Han Liu, Vijesh Vaghjiani, +6 authors, James Chan.
PLoS One, 2012 May 09; 7(4). PMID: 22563398    Free PMC article.
Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity.
Roland S Liblau, Hartmut Wekerle, Roland M Tisch.
Front Immunol, 2011 Jan 01; 2. PMID: 22566837    Free PMC article.
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity.
Patrick J Shaw, Stefan Feske.
J Physiol, 2012 May 23; 590(17). PMID: 22615435    Free PMC article.
Review.
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
Tao Zou, Atsushi Satake, +4 authors, Taku Kambayashi.
J Immunol, 2012 May 25; 189(1). PMID: 22623329    Free PMC article.
In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta.
Ana C Zenclussen, David N Olivieri, Michael L Dustin, Carlos E Tadokoro.
Am J Reprod Immunol, 2012 May 26; 68(3). PMID: 22626451    Free PMC article.
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
Shipra Gupta, Thomas B Thornley, +4 authors, Terry B Strom.
J Clin Invest, 2012 Jun 12; 122(7). PMID: 22684103    Free PMC article.
New insights of T cells in the pathogenesis of psoriasis.
Yihua Cai, Chris Fleming, Jun Yan.
Cell Mol Immunol, 2012 Jun 19; 9(4). PMID: 22705915    Free PMC article.
Review.
Boosting regulatory T cell function by CD4 stimulation enters the clinic.
Christian Becker, Tobias Bopp, Helmut Jonuleit.
Front Immunol, 2012 Jun 22; 3. PMID: 22719741    Free PMC article.
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance.
Mara Kornete, Ciriaco A Piccirillo.
Front Immunol, 2012 Jun 28; 3. PMID: 22737152    Free PMC article.
The Roles and Perspectives of Toll-Like Receptors and CD4(+) Helper T Cell Subsets in Acute Viral Encephalitis.
Young Woo Han, Sunit K Singh, Seong Kug Eo.
Immune Netw, 2012 Jun 29; 12(2). PMID: 22740790    Free PMC article.
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
Ada Yeste, Meghan Nadeau, +2 authors, Francisco J Quintana.
Proc Natl Acad Sci U S A, 2012 Jun 30; 109(28). PMID: 22745170    Free PMC article.
Highly Cited.
Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer.
Thomas Decker, Gerhard Fischer, +8 authors, Katharina Götze.
J Cancer Res Clin Oncol, 2012 Jul 05; 138(11). PMID: 22760213
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.
Guoyan Cheng, Xiaomei Yuan, +3 authors, Thomas R Malek.
J Immunol, 2012 Jul 13; 189(4). PMID: 22786769    Free PMC article.
FoxP3(+) T regulatory cells in oral lichen planus and its correlation with the distinct clinical appearance of the lesions.
Joabe S Pereira, Bárbara V Monteiro, +2 authors, Márcia C Miguel.
Int J Exp Pathol, 2012 Jul 19; 93(4). PMID: 22804765    Free PMC article.
SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU).
Barbara P Vistica, Guangpu Shi, +3 authors, Igal Gery.
Mol Vis, 2012 Jul 21; 18. PMID: 22815639    Free PMC article.
Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo.
Siddharth Jhunjhunwala, Giorgio Raimondi, +5 authors, Steven R Little.
Adv Mater, 2012 Jul 24; 24(35). PMID: 22821823    Free PMC article.
T cell signaling targets for enhancing regulatory or effector function.
Fan Pan, Huimin Fan, Zhongmin Liu, Shuiping Jiang.
Sci Signal, 2012 Aug 03; 5(235). PMID: 22855503    Free PMC article.
Targeting the intragraft microenvironment and the development of chronic allograft rejection.
Olivier Dormond, Marc Dufour, +2 authors, David M Briscoe.
Hum Immunol, 2012 Aug 07; 73(12). PMID: 22863981    Free PMC article.
Review.
Effect of Spa Spring Water on Cytokine Expression in Human Keratinocyte HaCaT Cells and on Differentiation of CD4(+) T Cells.
Ho-Pyo Lee, Yoon-Jung Choi, +6 authors, Jin-Wou Kim.
Ann Dermatol, 2012 Aug 11; 24(3). PMID: 22879717    Free PMC article.
Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice.
Julie C Antvorskov, Petra Fundova, Karsten Buschard, David P Funda.
Immunology, 2012 Aug 24; 138(1). PMID: 22913724    Free PMC article.
Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance.
Jared H Rowe, James M Ertelt, Lijun Xin, Sing Sing Way.
PLoS Pathog, 2012 Aug 24; 8(8). PMID: 22916020    Free PMC article.
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.
Sujin Hwang, Ki-Duk Song, +5 authors, Paul E Love.
J Exp Med, 2012 Sep 05; 209(10). PMID: 22945921    Free PMC article.
TNF receptor family signaling in the development and functions of medullary thymic epithelial cells.
Taishin Akiyama, Miho Shinzawa, Nobuko Akiyama.
Front Immunol, 2012 Sep 13; 3. PMID: 22969770    Free PMC article.
Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.
Jared H Rowe, James M Ertelt, Lijun Xin, Sing Sing Way.
Nature, 2012 Oct 02; 490(7418). PMID: 23023128    Free PMC article.
Highly Cited.
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
Jingxian Zhao, Jincun Zhao, Stanley Perlman.
PLoS One, 2012 Oct 03; 7(9). PMID: 23029447    Free PMC article.
β-cell preservation and regeneration for diabetes treatment: where are we now?
Michael J Karadimos, Archana Kapoor, Ilham El Khattabi, Arun Sharma.
Diabetes Manag (Lond), 2012 Oct 11; 2(3). PMID: 23049620    Free PMC article.
Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach.
Florence Brüll, Ronald P Mensink, +4 authors, Jogchum Plat.
PLoS One, 2012 Oct 24; 7(10). PMID: 23091602    Free PMC article.
Current and future immunomodulation strategies to restore tolerance in autoimmune diseases.
Jeffrey A Bluestone, Hélène Bour-Jordan.
Cold Spring Harb Perspect Biol, 2012 Nov 06; 4(11). PMID: 23125012    Free PMC article.
Review.
Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Jan-Hendrik Riedel, Hans-Joachim Paust, +12 authors, Ulf Panzer.
J Am Soc Nephrol, 2012 Nov 10; 23(12). PMID: 23138484    Free PMC article.
Neuroimmunology of the atherosclerotic plaque: a morphological approach.
Rita Businaro.
J Neuroimmune Pharmacol, 2012 Nov 15; 8(1). PMID: 23150034
Review.
PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells.
Feng He, Hairong Chen, +6 authors, Rudi Balling.
Mol Syst Biol, 2012 Nov 22; 8. PMID: 23169000    Free PMC article.
Glucocorticoid receptor BclI polymorphism associates with immunomodulatory response to stress hormone in human peripheral blood mononuclear cells.
L Xiang, G D Marshall.
Int J Immunogenet, 2012 Nov 28; 40(3). PMID: 23176645    Free PMC article.
Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Rebecca J Brownlie, Lisa A Miosge, +3 authors, Rose Zamoyska.
Sci Signal, 2012 Nov 30; 5(252). PMID: 23193160    Free PMC article.
Immune tolerance and transplantation.
Onder Alpdogan, Marcel R M van den Brink.
Semin Oncol, 2012 Dec 05; 39(6). PMID: 23206840    Free PMC article.
Review.
Methamphetamine administration targets multiple immune subsets and induces phenotypic alterations suggestive of immunosuppression.
Robert Harms, Brenda Morsey, +2 authors, Nora Sarvetnick.
PLoS One, 2012 Dec 12; 7(12). PMID: 23227154    Free PMC article.
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Michael G Strainic, Ethan M Shevach, +2 authors, M Edward Medof.
Nat Immunol, 2012 Dec 25; 14(2). PMID: 23263555    Free PMC article.
Highly Cited.
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Xin Chen, Xueqiang Wu, +3 authors, Joost J Oppenheim.
J Immunol, 2013 Jan 02; 190(3). PMID: 23277487    Free PMC article.
Highly Cited.
Intradermal application of vitamin D3 increases migration of CD14+ dermal dendritic cells and promotes the development of Foxp3+ regulatory T cells.
Ghaith Bakdash, Laura P Schneider, +3 authors, Esther C de Jong.
Hum Vaccin Immunother, 2013 Jan 08; 9(2). PMID: 23291929    Free PMC article.
Specialized role of migratory dendritic cells in peripheral tolerance induction.
Juliana Idoyaga, Christopher Fiorese, +6 authors, Ralph M Steinman.
J Clin Invest, 2013 Jan 10; 123(2). PMID: 23298832    Free PMC article.
Highly Cited.
Functional characterization of HLA-G⁺ regulatory T cells in HIV-1 infection.
Chun Li, Ilona Toth, +6 authors, Xu G Yu.
PLoS Pathog, 2013 Feb 06; 9(1). PMID: 23382678    Free PMC article.
Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants.
Suniti Bhaumik, Thierry Giffon, +4 authors, David A Randolph.
J Immunol, 2013 Feb 13; 190(6). PMID: 23401586    Free PMC article.
Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals.
Weiting Du, Yueh-Wei Shen, +4 authors, Chih-Pin Liu.
PLoS One, 2013 Feb 15; 8(2). PMID: 23409157    Free PMC article.
CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice.
Olivia Weigert, Caroline von Spee, +3 authors, Gabriela Riemekasten.
Arthritis Res Ther, 2013 Mar 01; 15(1). PMID: 23446139    Free PMC article.
The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses.
María Guadalupe Reyes García, Fernando García Tamayo.
Biomed Res Int, 2013 Mar 20; 2013. PMID: 23509712    Free PMC article.
Review.
T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques.
Stéphane Champiat, Keith E Garrison, +18 authors, Douglas F Nixon.
J Virol, 2013 Mar 29; 87(11). PMID: 23536679    Free PMC article.
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
Ken-ichi Matsuoka, John Koreth, +12 authors, Jerome Ritz.
Sci Transl Med, 2013 Apr 05; 5(179). PMID: 23552371    Free PMC article.
Highly Cited.
Immunosenescence and organ transplantation.
Timm Heinbokel, Abdallah Elkhal, +2 authors, Stefan G Tullius.
Transplant Rev (Orlando), 2013 May 04; 27(3). PMID: 23639337    Free PMC article.
Review.
Fingolimod modulates peripheral effector and regulatory T cells in MS patients.
Laura D Serpero, Gilberto Filaci, +6 authors, Daniela Fenoglio.
J Neuroimmune Pharmacol, 2013 May 08; 8(5). PMID: 23649711    Free PMC article.
Rodent models for investigating the dysregulation of immune responses in type 1 diabetes.
Feng-Cheng Chou, Heng-Yi Chen, +2 authors, Huey-Kang Sytwu.
J Diabetes Res, 2013 May 15; 2013. PMID: 23671851    Free PMC article.
Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.
Wenyuan Jia, Li Cao, +6 authors, Chen Wang.
PLoS One, 2013 May 16; 8(5). PMID: 23675534    Free PMC article.
Foxp3(+) regulatory T cells in mouse models of type 1 diabetes.
Cathleen Petzold, Julia Riewaldt, +3 authors, Karsten Kretschmer.
J Diabetes Res, 2013 May 22; 2013. PMID: 23691523    Free PMC article.
CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model.
Lam Quoc Bao, Nguyen Tien Huy, +6 authors, Kenji Hirayama.
PLoS One, 2013 Jun 01; 8(5). PMID: 23724100    Free PMC article.
Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy.
Brigitte Santner-Nanan, Kathrin Straubinger, +9 authors, Ralph Nanan.
J Immunol, 2013 Jun 05; 191(1). PMID: 23733877    Free PMC article.
Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus.
Daniela Pedicino, Giovanna Liuzzo, +12 authors, Filippo Crea.
J Diabetes Res, 2013 Jun 14; 2013. PMID: 23762872    Free PMC article.
Orchestration of CD4 T cell epitope preferences after multipeptide immunization.
Jacqueline Tung, Andrea J Sant.
J Immunol, 2013 Jun 19; 191(2). PMID: 23772029    Free PMC article.
Development of a transgenic mouse model with immune tolerance for human coagulation factor VIIa.
Christine Lenk, Sabine Unterthurner, +7 authors, Birgit M Reipert.
Pharm Res, 2013 Jun 19; 30(11). PMID: 23775444
Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.
Aicha Jrad-Lamine, Joelle Henry-Berger, +11 authors, Joël R Drevet.
PLoS One, 2013 Jul 11; 8(6). PMID: 23840489    Free PMC article.
Antigen-based vaccination and prevention of type 1 diabetes.
Leonard C Harrison, John M Wentworth, +10 authors, Grant Morahan.
Curr Diab Rep, 2013 Jul 28; 13(5). PMID: 23888323
Review.
MicroRNA-mediated regulation of T helper cell differentiation and plasticity.
Dirk Baumjohann, K Mark Ansel.
Nat Rev Immunol, 2013 Aug 03; 13(9). PMID: 23907446    Free PMC article.
Highly Cited. Review.
IL-17 gene ablation does not impact Treg-mediated suppression of graft-versus-host disease after bone marrow transplantation.
Lucrezia Colonna, Mareike Florek, +4 authors, Robert S Negrin.
Biol Blood Marrow Transplant, 2013 Aug 08; 19(11). PMID: 23921175    Free PMC article.
Regulatory T cells and the immune pathogenesis of prenatal infection.
Jared H Rowe, James M Ertelt, Lijun Xin, Sing Sing Way.
Reproduction, 2013 Aug 10; 146(6). PMID: 23929902    Free PMC article.
Review.
Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.
Iren Bains, Hisse M van Santen, Benedict Seddon, Andrew J Yates.
PLoS Comput Biol, 2013 Aug 13; 9(7). PMID: 23935465    Free PMC article.
Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells.
Yuxia Zhang, Jovana Maksimovic, +5 authors, Leonard C Harrison.
Blood, 2013 Aug 27; 122(16). PMID: 23974203    Free PMC article.
Aryl hydrocarbon receptor and experimental autoimmune arthritis.
Nam Trung Nguyen, Taisuke Nakahama, Tadamitsu Kishimoto.
Semin Immunopathol, 2013 Aug 29; 35(6). PMID: 23982178
Review.
PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?
Laurindo Ferreira da Rocha Junior, Andréa Tavares Dantas, +3 authors, Maira Galdino da Rocha Pitta.
PPAR Res, 2013 Aug 29; 2013. PMID: 23983678    Free PMC article.
Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3.
B Linju Yen, Men-Luh Yen, +4 authors, Huey-Kang Sytwu.
Stem Cell Reports, 2013 Sep 21; 1(2). PMID: 24052949    Free PMC article.
Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice.
Patrícia P Corsetti, Leonardo A de Almeida, +5 authors, Sergio C Oliveira.
PLoS One, 2013 Sep 27; 8(9). PMID: 24069337    Free PMC article.
Genetic variants regulating immune cell levels in health and disease.
Valeria Orrù, Maristella Steri, +49 authors, Francesco Cucca.
Cell, 2013 Oct 01; 155(1). PMID: 24074872    Free PMC article.
Highly Cited.
Regulatory T cells and vasectomy.
Claudia Rival, Karen Wheeler, +9 authors, Kenneth Tung.
J Reprod Immunol, 2013 Oct 02; 100(1). PMID: 24080233    Free PMC article.
Itch expression by Treg cells controls Th2 inflammatory responses.
Hyung-seung Jin, Yoon Park, Chris Elly, Yun-Cai Liu.
J Clin Invest, 2013 Oct 19; 123(11). PMID: 24135136    Free PMC article.
Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib.
M Massa, V Rosti, +2 authors, G Barosi.
Leukemia, 2013 Oct 23; 28(2). PMID: 24145312
Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1.
Stefano Angiari, Barbara Rossi, +13 authors, Gabriela Constantin.
J Immunol, 2013 Nov 01; 191(11). PMID: 24174617    Free PMC article.
Tolerance and exhaustion: defining mechanisms of T cell dysfunction.
Andrea Schietinger, Philip D Greenberg.
Trends Immunol, 2013 Nov 12; 35(2). PMID: 24210163    Free PMC article.
Highly Cited. Review.
Induction and stability of the anergic phenotype in T cells.
Rut Valdor, Fernando Macian.
Semin Immunol, 2013 Nov 12; 25(4). PMID: 24211041    Free PMC article.
Review.
Regulatory T cells in colorectal cancer: from biology to prognostic relevance.
Dimitrios Mougiakakos.
Cancers (Basel), 2011 Jan 01; 3(2). PMID: 24212779    Free PMC article.
Regulatory T cells in peripheral blood and cerebrospinal fluid of syphilis patients with and without neurological involvement.
Kang Li, Cuini Wang, +3 authors, Pingyu Zhou.
PLoS Negl Trop Dis, 2013 Nov 19; 7(11). PMID: 24244772    Free PMC article.
Distribution of CD4(pos) -, CD8(pos) - and regulatory T cells in the upper and lower gastrointestinal tract in healthy young subjects.
Martin Tauschmann, Barbara Prietl, +4 authors, Thomas R Pieber.
PLoS One, 2013 Nov 23; 8(11). PMID: 24265815    Free PMC article.
Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice.
Jessica R Lakritz, Theofilos Poutahidis, +6 authors, Susan E Erdman.
Int J Cancer, 2014 Jan 03; 135(3). PMID: 24382758    Free PMC article.
Human mesenchymal stromal cells from adult and neonatal sources: a comparative in vitro analysis of their immunosuppressive properties against T cells.
Marta E Castro-Manrreza, Hector Mayani, +5 authors, Juan José Montesinos.
Stem Cells Dev, 2014 Jan 17; 23(11). PMID: 24428376    Free PMC article.
Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP).
R M Talaat, A M Elmaghraby, S S Barakat, M El-Shahat.
Clin Exp Immunol, 2014 Jan 28; 176(2). PMID: 24460857    Free PMC article.
Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients.
Song Gao, Bing Hao, Xu Feng Yang, Wei Qian Chen.
Inflamm Res, 2014 Feb 06; 63(6). PMID: 24496593
The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.
Guanying Wang, Roy Y Kim, +9 authors, Robert L Raffai.
J Cardiovasc Pharmacol, 2014 Feb 11; 63(2). PMID: 24508946    Free PMC article.
Foxp3⁺ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice.
Birte Blankenhaus, Martina Reitz, +9 authors, Minka Breloer.
PLoS Pathog, 2014 Feb 12; 10(2). PMID: 24516385    Free PMC article.
Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells.
J Niu, W Yue, +6 authors, X Hu.
Clin Exp Immunol, 2014 Feb 18; 176(3). PMID: 24527865    Free PMC article.
Correlation of interleukin-17-producing effector memory T cells and CD4+CD25+Foxp3 regulatory T cells with the phosphate levels in chronic hemodialysis patients.
Cheng-Lin Lang, Min-Hui Wang, +3 authors, Kuo-Cheng Lu.
ScientificWorldJournal, 2014 Feb 22; 2014. PMID: 24558316    Free PMC article.
Inhibition of the interleukin-6 signaling pathway: a strategy to induce immune tolerance.
Cheng Zhang, Xi Zhang, Xing-Hua Chen.
Clin Rev Allergy Immunol, 2014 Mar 22; 47(2). PMID: 24647663
Review.
CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
Tomohiro Koga, Christian M Hedrich, +6 authors, George C Tsokos.
J Clin Invest, 2014 Mar 29; 124(5). PMID: 24667640    Free PMC article.
Highly Cited.
T-cell selection and intestinal homeostasis.
Teresa L Ai, Benjamin D Solomon, Chyi-Song Hsieh.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712459    Free PMC article.
Review.
Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia.
Peter Hsu, Ralph Kay Heinrich Nanan.
Front Immunol, 2014 Apr 16; 5. PMID: 24734032    Free PMC article.
Review.
Heterogeneity in immune responses: from populations to single cells.
Rahul Satija, Alex K Shalek.
Trends Immunol, 2014 Apr 22; 35(5). PMID: 24746883    Free PMC article.
Review.
New inhibitory signaling by CTLA-4.
Christoph Wülfing, Helen M Tunbridge, David C Wraith.
Nat Immunol, 2014 Apr 22; 15(5). PMID: 24747703
Protective effect of cytosolic phospholipase A2 inhibition against inflammation and degeneration by promoting regulatory T cells in rats with experimental autoimmune encephalomyelitis.
Dan Yang, Hong-Fei Ji, +6 authors, Wei-Zhi Wang.
Mediators Inflamm, 2014 May 02; 2014. PMID: 24782598    Free PMC article.
MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice.
Li Zhang, Pilar Londono, +4 authors, George S Eisenbarth.
Autoimmunity, 2014 May 03; 47(5). PMID: 24783965    Free PMC article.
Effects of stress on immune function: the good, the bad, and the beautiful.
Firdaus S Dhabhar.
Immunol Res, 2014 May 07; 58(2-3). PMID: 24798553
Highly Cited. Review.
Rho-GTPases as key regulators of T lymphocyte biology.
Abdelhadi Saoudi, Sahar Kassem, Anne Dejean, Guillaume Gaud.
Small GTPases, 2014 May 16; 5. PMID: 24825161    Free PMC article.
Review.
Aging of the CD4 T Cell Compartment.
Julie S Lefebvre, Laura Haynes.
Open Longev Sci, 2012 Jan 01; 6. PMID: 24839469    Free PMC article.
Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.
Kazuyuki Murase, Haesook T Kim, +14 authors, Jerome Ritz.
Haematologica, 2014 May 27; 99(9). PMID: 24859877    Free PMC article.
T cells and intestinal commensal bacteria--ignorance, rejection, and acceptance.
Jiani N Chai, You W Zhou, Chyi-Song Hsieh.
FEBS Lett, 2014 Jul 06; 588(22). PMID: 24997344    Free PMC article.
Review.
Autoimmunity versus autoinflammation--friend or foe?
Nobuo Kanazawa, Georgi Tchernev, Uwe Wollina.
Wien Med Wochenschr, 2014 Jul 10; 164(13-14). PMID: 25004809
Review.
Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling.
Weisong Zhou, Kasia Goleniewska, +11 authors, R Stokes Peebles.
J Allergy Clin Immunol, 2014 Jul 22; 134(3). PMID: 25042746    Free PMC article.
Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.
Ashenafi Y Tilahun, Vaidehi R Chowdhary, Chella S David, Govindarajan Rajagopalan.
J Immunol, 2014 Aug 06; 193(6). PMID: 25092888    Free PMC article.
Preparing the ground for tissue regeneration: from mechanism to therapy.
Stuart J Forbes, Nadia Rosenthal.
Nat Med, 2014 Aug 08; 20(8). PMID: 25100531
Highly Cited. Review.
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system.
Jianping Wang, Lie Yu, +7 authors, Jian Wang.
Brain Behav Immun, 2014 Aug 12; 43. PMID: 25110149    Free PMC article.
Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.
Kevin Y Lin, Justin H Lo, +2 authors, Sangeeta N Bhatia.
ACS Nano, 2014 Aug 15; 8(9). PMID: 25119520    Free PMC article.
Immunoregulatory T cells, LFA-3 and HLA-DR in autoimmune thyroid diseases.
Aml Mohamed Nada, Maha Hammouda.
Indian J Endocrinol Metab, 2014 Aug 22; 18(4). PMID: 25143920    Free PMC article.
Propofol's effect on the sciatic nerve: Harmful or protective?
Yi Sun, Xizhe Zhang, +3 authors, Jian Cao.
Neural Regen Res, 2014 Sep 11; 8(27). PMID: 25206562    Free PMC article.
Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.
Pedro Milanez-Almeida, Frank Klawonn, Michael Meyer-Hermann, Jochen Huehn.
Eur J Microbiol Immunol (Bp), 2014 Sep 13; 4(3). PMID: 25215190    Free PMC article.
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus.
Justin S A Perry, Chan-Wang J Lio, +5 authors, Chyi-Song Hsieh.
Immunity, 2014 Sep 16; 41(3). PMID: 25220213    Free PMC article.
Highly Cited.
Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy.
Shirin Karimi, Subhasis Chattopadhyay, Nitya G Chakraborty.
Immunology, 2014 Sep 23; 144(2). PMID: 25243729    Free PMC article.
Review.
Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity.
Agata Kosmaczewska.
Int J Mol Sci, 2014 Oct 17; 15(10). PMID: 25322151    Free PMC article.
Review.
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
Daniel Bilbao, Luisa Luciani, +2 authors, Nadia Rosenthal.
EMBO Mol Med, 2014 Oct 24; 6(11). PMID: 25339185    Free PMC article.
Interleukin 2 in the pathogenesis and therapy of type 1 diabetes.
Michelle Rosenzwajg, Guillaume Churlaud, Agnès Hartemann, David Klatzmann.
Curr Diab Rep, 2014 Oct 27; 14(12). PMID: 25344788
Review.
Quantitative T cell subsets profile in peripheral blood from patients with idiopathic inflammatory myopathies: tilting the balance towards proinflammatory and pro-apoptotic subsets.
F Espinosa-Ortega, D Gómez-Martin, +3 authors, J Alcocer-Varela.
Clin Exp Immunol, 2014 Oct 29; 179(3). PMID: 25348796    Free PMC article.
Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.
L A O'Reilly, P Hughes, +6 authors, A Strasser.
Cell Death Differ, 2014 Nov 02; 22(5). PMID: 25361085    Free PMC article.
Analysis of FoxP3+ T-regulatory cells and CD8+ T-cells in ovarian carcinoma: location and tumor infiltration patterns are key prognostic markers.
Cecilia Hermans, David Anz, +3 authors, Doris Mayr.
PLoS One, 2014 Nov 05; 9(11). PMID: 25365237    Free PMC article.
Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain-Barré syndrome patients.
Mohan S Maddur, Magalie Rabin, +6 authors, Srini V Kaveri.
Immunol Res, 2014 Nov 14; 60(2-3). PMID: 25391612
Tolerogenic splenic IDO (+) dendritic cells from the mice treated with induced-Treg cells suppress collagen-induced arthritis.
Jie Yang, Yiming Yang, Huahua Fan, Hejian Zou.
J Immunol Res, 2014 Nov 19; 2014. PMID: 25405209    Free PMC article.
Inflammation and hypertension: new understandings and potential therapeutic targets.
Carmen De Miguel, Nathan P Rudemiller, Justine M Abais, David L Mattson.
Curr Hypertens Rep, 2014 Nov 30; 17(1). PMID: 25432899    Free PMC article.
Review.
Tumor antigen-specific monoclonal antibodies and induction of T-cell immunity.
Sumita Trivedi, Hyun-Bae Jie, Robert L Ferris.
Semin Oncol, 2014 Dec 03; 41(5). PMID: 25440612    Free PMC article.
Review.
Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.
Cesar M Rueda, Casey B Wells, +3 authors, Claire A Chougnet.
Hum Immunol, 2014 Dec 03; 76(1). PMID: 25451985    Free PMC article.
IL-17A-mediated protection against Acanthamoeba keratitis.
Amol Suryawanshi, Zhiyi Cao, James F Sampson, Noorjahan Panjwani.
J Immunol, 2014 Dec 17; 194(2). PMID: 25505284    Free PMC article.
FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer.
Changhua Zhuo, Ye Xu, +5 authors, Bin Li.
Immunol Res, 2015 Jan 23; 61(3). PMID: 25608795
Review.
FOXP3+ regulatory T cells and their functional regulation.
Zhiyuan Li, Dan Li, Andy Tsun, Bin Li.
Cell Mol Immunol, 2015 Feb 17; 12(5). PMID: 25683611    Free PMC article.
Review.
The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study.
Antonella Afeltra, Antonietta Gigante, +6 authors, Filippo Rossi Fanelli.
Intern Emerg Med, 2015 Feb 28; 10(6). PMID: 25720575
Autoimmune hepatitis.
Farhad Sahebjam, John M Vierling.
Front Med, 2015 Mar 10; 9(2). PMID: 25749982
Review.
Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment.
Stefano Garetto, Anna Elisa Trovato, +6 authors, Marinos Kallikourdis.
Immunobiology, 2015 Mar 15; 220(8). PMID: 25770018    Free PMC article.
The immunobiology of the mammalian epididymis: the black box is now open!
Rachel Guiton, Joelle Henry-Berger, Joël R Drevet.
Basic Clin Androl, 2013 Jan 01; 23. PMID: 25780570    Free PMC article.
Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease.
Colleen Elizabeth Hayes, Shane L Hubler, +3 authors, Faye E Nashold.
Front Immunol, 2015 Apr 09; 6. PMID: 25852682    Free PMC article.
Review.
Three-Dimensional Gradients of Cytokine Signaling between T Cells.
Kevin Thurley, Daniel Gerecht, Elfriede Friedmann, Thomas Höfer.
PLoS Comput Biol, 2015 Apr 30; 11(4). PMID: 25923703    Free PMC article.
CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.
Qi-Quan Huang, Harris Perlman, +9 authors, Richard M Pope.
Nat Commun, 2015 May 13; 6. PMID: 25963626    Free PMC article.
T cells in the control of organ-specific autoimmunity.
Jeffrey A Bluestone, Hélène Bour-Jordan, Mickie Cheng, Mark Anderson.
J Clin Invest, 2015 May 20; 125(6). PMID: 25985270    Free PMC article.
Review.
Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
Guoping Deng, Yasuhiro Nagai, +10 authors, Mark I Greene.
J Biol Chem, 2015 May 20; 290(33). PMID: 25987564    Free PMC article.
Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.
Wong Yu, Ning Jiang, +13 authors, Mark M Davis.
Immunity, 2015 May 21; 42(5). PMID: 25992863    Free PMC article.
Highly Cited.
Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.
Monica A McArthur, Stephanie Fresnay, +9 authors, Marcelo B Sztein.
PLoS Pathog, 2015 May 23; 11(5). PMID: 26001081    Free PMC article.
Gut bacteria and cancer.
Susan E Erdman, Theofilos Poutahidis.
Biochim Biophys Acta, 2015 Jun 09; 1856(1). PMID: 26050963    Free PMC article.
Review.
Regulatory immune cells in regulation of intestinal inflammatory response to microbiota.
M Sun, C He, Y Cong, Z Liu.
Mucosal Immunol, 2015 Jun 18; 8(5). PMID: 26080708    Free PMC article.
Highly Cited. Review.
The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease.
Jane C Burns, Alessandra Franco.
Expert Rev Clin Immunol, 2015 Jun 24; 11(7). PMID: 26099344    Free PMC article.
Review.
The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.
Xin Xie, Michael J T Stubbington, +4 authors, Alexander G Betz.
PLoS Genet, 2015 Jun 25; 11(6). PMID: 26107960    Free PMC article.
Development of depressive symptoms post hip fracture is associated with altered immunosuppressive phenotype in regulatory T and B lymphocytes.
Niharika Arora Duggal, Jane Upton, Anna C Phillips, Janet M Lord.
Biogerontology, 2015 Jun 27; 17(1). PMID: 26112234    Free PMC article.
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.
Tawfik Khoury, Ami Ben Ya'acov, +3 authors, Yaron Ilan.
World J Gastroenterol, 2015 Jul 04; 21(24). PMID: 26139990    Free PMC article.
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Kyle Leonard O'Hagan, Jinyong Choi, +2 authors, Hyewon Phee.
J Immunol, 2015 Jul 15; 195(4). PMID: 26157175    Free PMC article.
MicroRNA-26a Promotes Regulatory T cells and Suppresses Autoimmune Diabetes in Mice.
Hui Ma, Shoutao Zhang, +2 authors, Jianguo Cui.
Inflammation, 2015 Jul 26; 39(1). PMID: 26208605
Immune interventions to preserve β cell function in type 1 diabetes.
Mario R Ehlers.
J Investig Med, 2015 Aug 01; 64(1). PMID: 26225763    Free PMC article.
Review.
Translating transitions - how to decipher peripheral human B cell development.
Mats Bemark.
J Biomed Res, 2015 Aug 06; 29(4). PMID: 26243514    Free PMC article.
Review.
Defects in Germinal Center Selection in SLE.
Megan Woods, Yong-Rui Zou, Anne Davidson.
Front Immunol, 2015 Sep 01; 6. PMID: 26322049    Free PMC article.
Review.
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Reid A Roberts, Timothy K Eitas, +7 authors, Jenny P Ting.
Biomaterials, 2015 Sep 02; 72. PMID: 26325217    Free PMC article.
Targeting memory T cells in type 1 diabetes.
Mario R Ehlers, Mark R Rigby.
Curr Diab Rep, 2015 Sep 16; 15(11). PMID: 26370695
Review.
MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression.
Dan Li, Chao Kong, +7 authors, Bin Li.
Sci Rep, 2015 Oct 02; 5. PMID: 26424054    Free PMC article.
Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.
Jaxaira Maggi, Carolina Schafer, +3 authors, Juan C Aguillón.
Front Immunol, 2015 Oct 07; 6. PMID: 26441992    Free PMC article.
Review.
Immunosuppressive mechanisms in glioblastoma.
Edjah K Nduom, Michael Weller, Amy B Heimberger.
Neuro Oncol, 2015 Oct 31; 17 Suppl 7. PMID: 26516226    Free PMC article.
Highly Cited. Review.
Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria.
Anne-Laurence Blanc, Tarun Keswani, +4 authors, Sylviane Pied.
Infect Immun, 2015 Nov 11; 84(1). PMID: 26553468    Free PMC article.
Comparing the Immunomodulatory Properties of Bone Marrow, Adipose Tissue, and Birth-Associated Tissue Mesenchymal Stromal Cells.
Philipp Mattar, Karen Bieback.
Front Immunol, 2015 Nov 19; 6. PMID: 26579133    Free PMC article.
Highly Cited. Review.
PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia.
Cristina Peligero, Jordi Argilaguet, +7 authors, Andreas Meyerhans.
PLoS Pathog, 2015 Dec 04; 11(12). PMID: 26633181    Free PMC article.
Therapies to Preserve β-Cell Function in Type 1 Diabetes.
Johnny Ludvigsson.
Drugs, 2015 Dec 10; 76(2). PMID: 26645223
Review.
The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.
Nathan Karin, Gizi Wildbaum.
Front Immunol, 2015 Dec 10; 6. PMID: 26648938    Free PMC article.
Review.
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
Ulrike Kaufmann, Patrick J Shaw, +5 authors, Stefan Feske.
J Immunol, 2015 Dec 18; 196(2). PMID: 26673135    Free PMC article.
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.
Deepali Malhotra, Jonathan L Linehan, +9 authors, Marc K Jenkins.
Nat Immunol, 2016 Jan 05; 17(2). PMID: 26726812    Free PMC article.
Highly Cited.
Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.
Uri Sela, Chae Gyu Park, +4 authors, Vincent A Fischetti.
PLoS One, 2016 Jan 09; 11(1). PMID: 26745371    Free PMC article.
Immune Cell Identity: Perspective from a Palimpsest.
Ellen V Rothenberg.
Perspect Biol Med, 2016 Jan 12; 58(2). PMID: 26750603    Free PMC article.
Central tolerance: what you see is what you don't get!
Douglas G Millar, Pamela S Ohashi.
Nat Immunol, 2016 Jan 20; 17(2). PMID: 26784256
Beneficial bacteria inhibit cachexia.
Bernard J Varian, Sravya Gourishetti, +7 authors, Susan E Erdman.
Oncotarget, 2016 Mar 05; 7(11). PMID: 26933816    Free PMC article.
Contribution of MicroRNAs to autoimmune diseases.
Lucien P Garo, Gopal Murugaiyan.
Cell Mol Life Sci, 2016 Mar 05; 73(10). PMID: 26943802
Review.
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
Nobumasa Watanabe, Osamu Kaminuma, Noriko Kitamura, Takachika Hiroi.
PLoS One, 2016 Mar 08; 11(3). PMID: 26950218    Free PMC article.
A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis.
Kozo Miyatani, Hiroaki Saito, +8 authors, Masahide Ikeguchi.
Virchows Arch, 2016 Mar 10; 468(5). PMID: 26951261
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Sarah Sharon Gabriel, Nina Bon, +4 authors, Pietro Ernesto Cippà.
Front Immunol, 2016 Mar 15; 7. PMID: 26973650    Free PMC article.
A primer on tumour immunology and prostate cancer immunotherapy.
Runhan Ren, Madhuri Koti, +5 authors, D Robert Siemens.
Can Urol Assoc J, 2016 Mar 16; 10(1-2). PMID: 26977209    Free PMC article.
Review.
Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque.
Cesar M Rueda, Pietro Presicce, +4 authors, Claire A Chougnet.
J Immunol, 2016 Apr 03; 196(9). PMID: 27036917    Free PMC article.
Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses.
Wujing Dai, Fangwei Liu, +6 authors, Jie Chen.
Mediators Inflamm, 2016 Apr 14; 2016. PMID: 27069316    Free PMC article.
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis.
Shu-Yi Yin, Feng-Yin Jian, +6 authors, Ning-Sun Yang.
Nat Commun, 2016 Apr 19; 7. PMID: 27089063    Free PMC article.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.
J Pagel, A Hartz, +11 authors, C Härtel.
Clin Exp Immunol, 2016 May 11; 185(2). PMID: 27163159    Free PMC article.
Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
Rachel K Rowe, Gavin I Ellis, +6 authors, Jonathan Lifshitz.
Mol Pain, 2016 May 15; 12. PMID: 27178244    Free PMC article.
Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet.
Danielle M Lussier, Eric C Woolf, +3 authors, Adrienne C Scheck.
BMC Cancer, 2016 May 15; 16. PMID: 27178315    Free PMC article.
Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis.
Nam Trung Nguyen, Taisuke Nakahama, +4 authors, Tadamitsu Kishimoto.
J Exp Pharmacol, 2015 Jan 01; 7. PMID: 27186143    Free PMC article.
Review.
Retinoic Acid as a Modulator of T Cell Immunity.
Maria Rosa Bono, Gabriela Tejon, +3 authors, Daniela Sauma.
Nutrients, 2016 Jun 16; 8(6). PMID: 27304965    Free PMC article.
Review.
Circulating level of regulatory T cells in rheumatic heart disease: An observational study.
Saibal Mukhopadhyay, Saurabh Varma, +4 authors, Sanjay Tyagi.
Indian Heart J, 2016 Jun 19; 68(3). PMID: 27316488    Free PMC article.
Preeclampsia and health risks later in life: an immunological link.
Shi-Bin Cheng, Surendra Sharma.
Semin Immunopathol, 2016 Jun 25; 38(6). PMID: 27339196
Review.
Novel perspectives on therapeutic modulation of the gut microbiota.
Justin L McCarville, Alberto Caminero, Elena F Verdu.
Therap Adv Gastroenterol, 2016 Jul 02; 9(4). PMID: 27366225    Free PMC article.
Review.
The balance between Foxp3 and Ror-γt expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis.
Yoshifumi Tada, Nobuyuki Ono, +8 authors, Syuichi Koarada.
BMC Musculoskelet Disord, 2016 Jul 17; 17. PMID: 27421886    Free PMC article.
CD4+FOXP3+ T regulatory cells decrease and CD3+CD8+ T cells recruitment in TILs from melanoma metastases after electrochemotherapy.
P Di Gennaro, G Gerlini, +4 authors, L Borgognoni.
Clin Exp Metastasis, 2016 Aug 01; 33(8). PMID: 27475809
Ubc13: the Lys63 ubiquitin chain building machine.
Curtis D Hodge, Leo Spyracopoulos, J N Mark Glover.
Oncotarget, 2016 Aug 04; 7(39). PMID: 27486774    Free PMC article.
Review.
Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.
Luciana Bento-de-Souza, Jefferson R Victor, +7 authors, Alberto J Silva Duarte.
Results Immunol, 2016 Aug 10; 6. PMID: 27504259    Free PMC article.
Prion diseases: immunotargets and therapy.
Jennifer T Burchell, Peter K Panegyres.
Immunotargets Ther, 2016 Aug 17; 5. PMID: 27529062    Free PMC article.
Review.
Role of Metabolism in the Immunobiology of Regulatory T Cells.
Mario Galgani, Veronica De Rosa, Antonio La Cava, Giuseppe Matarese.
J Immunol, 2016 Sep 18; 197(7). PMID: 27638939    Free PMC article.
Review.
Adoptive Regulatory T-cell Therapy Attenuates Perihematomal Inflammation in a Mouse Model of Experimental Intracerebral Hemorrhage.
Lei-Lei Mao, Hui Yuan, +5 authors, Xiao-Yi Yang.
Cell Mol Neurobiol, 2016 Sep 30; 37(5). PMID: 27678140
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.
Kenneth R Cooke, Leo Luznik, +14 authors, Bruce R Blazar.
Biol Blood Marrow Transplant, 2016 Oct 08; 23(2). PMID: 27713092    Free PMC article.
Highly Cited. Review.
Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.
Consuelo M López De Padilla, Cynthia S Crowson, +7 authors, Ann M Reed.
J Rheumatol, 2016 Nov 03; 44(1). PMID: 27803134    Free PMC article.
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells.
Masahiro Hirakawa, Tiago R Matos, +16 authors, Jerome Ritz.
JCI Insight, 2016 Nov 05; 1(18). PMID: 27812545    Free PMC article.
Gut microbiota modulate host immune cells in cancer development and growth.
Susan E Erdman, Theofilos Poutahidis.
Free Radic Biol Med, 2016 Nov 15; 105. PMID: 27840315    Free PMC article.
Review.
T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective.
Mohammad Afzal Khan.
Mol Med, 2016 Nov 24; 22. PMID: 27878210    Free PMC article.
Foxp3, Regulatory T Cell, and Autoimmune Diseases.
Jin-Hui Tao, Miao Cheng, +3 authors, Xiang-Pei Li.
Inflammation, 2016 Nov 25; 40(1). PMID: 27882473
Review.
Effects of royal jelly supplementation on regulatory T cells in children with SLE.
Asmaa M Zahran, Khalid I Elsayh, +5 authors, Mohamed H Mahmoud.
Food Nutr Res, 2016 Nov 27; 60. PMID: 27887663    Free PMC article.
Immunoregulation in Fungal Diseases.
Jonathan A Roussey, Michal A Olszewski, John J Osterholzer.
Microorganisms, 2016 Dec 16; 4(4). PMID: 27973396    Free PMC article.
Review.
Allorecognition by T Lymphocytes and Allograft Rejection.
Jose Marino, Joshua Paster, Gilles Benichou.
Front Immunol, 2016 Dec 27; 7. PMID: 28018349    Free PMC article.
Review.
Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo.
Jiacong Yan, Bo Liu, Yan Shi, Hai Qi.
J Exp Med, 2017 Jan 14; 214(2). PMID: 28082359    Free PMC article.
Oncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells.
Hye-Jin Son, Seung Hoon Lee, +6 authors, Mi-La Cho.
J Immunol, 2017 Jan 18; 198(4). PMID: 28093521    Free PMC article.
Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells.
Michel Lecendreux, Guillaume Churlaud, +5 authors, Michelle Rosenzwajg.
PLoS One, 2017 Jan 21; 12(1). PMID: 28107375    Free PMC article.
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Takeru Asano, Yusuke Meguri, +17 authors, Ken-Ichi Matsuoka.
Blood, 2017 Feb 06; 129(15). PMID: 28151427    Free PMC article.
Highly Cited.
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
H C Jeffery, L E Jeffery, +5 authors, Y H Oo.
Clin Exp Immunol, 2017 Feb 09; 188(3). PMID: 28176332    Free PMC article.
Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective.
Esma S Yolcu, Haval Shirwan, Nadir Askenasy.
Stem Cells Transl Med, 2017 Feb 12; 6(3). PMID: 28186688    Free PMC article.
Review.
Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.
Nobuyuki Ono, Kiichi Murakami, +7 authors, Salim Dhanji.
PLoS One, 2017 Mar 04; 12(3). PMID: 28257518    Free PMC article.
T cell costimulation blockade blunts pressure overload-induced heart failure.
Marinos Kallikourdis, Elisa Martini, +15 authors, Gianluigi Condorelli.
Nat Commun, 2017 Mar 07; 8. PMID: 28262700    Free PMC article.
Highly Cited.
Tyrosine kinase inhibitors reprogramming immunity in renal cell carcinoma: rethinking cancer immunotherapy.
L M A Aparicio, I P Fernandez, J Cassinello.
Clin Transl Oncol, 2017 Apr 15; 19(10). PMID: 28409322    Free PMC article.
Review.
Repairing effects of ICAM-1-expressing mesenchymal stem cells in mice with autoimmune thyroiditis.
Shifeng Ma, Xiuhui Chen, +7 authors, Yi Zhang.
Exp Ther Med, 2017 Apr 18; 13(4). PMID: 28413469    Free PMC article.
Modulatory role of regulatory T cells in a murine model of severe equine asthma.
Claudio Henríquez, Gabriel Morán, +4 authors, Benjamin Uberti.
BMC Vet Res, 2017 Apr 30; 13(1). PMID: 28454585    Free PMC article.
Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms.
Katarzyna Bocian, Ewelina Kiernozek, +3 authors, Nadzieja Drela.
Arch Immunol Ther Exp (Warsz), 2017 May 10; 65(6). PMID: 28477096    Free PMC article.
Review.
A possible role of low regulatory T cells in anti-acetylcholine receptor antibody positive myasthenia gravis after bone marrow transplantation.
Masahiko Fukatsu, Takenobu Murakami, +15 authors, Yoshikazu Ugawa.
BMC Neurol, 2017 May 17; 17(1). PMID: 28506261    Free PMC article.
Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice.
Rongying Ou, Jia Liu, +5 authors, Yunsheng Xu.
Endocrine, 2017 May 17; 57(1). PMID: 28508193
CCR8+FOXp3+ Treg cells as master drivers of immune regulation.
Yiftah Barsheshet, Gizi Wildbaum, +5 authors, Nathan Karin.
Proc Natl Acad Sci U S A, 2017 May 24; 114(23). PMID: 28533380    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Association of increased Treg and Th17 with pathogenesis of moyamoya disease.
Leihua Weng, Xiang Cao, +12 authors, Yun Xu.
Sci Rep, 2017 Jun 10; 7(1). PMID: 28596558    Free PMC article.
Decreased Serum Concentration of Total IgG Is Related to Tumor Progression in Gastric Cancer Patients.
Hiroaki Saito, Kozo Miyatani, +7 authors, Yoshiyuki Fujiwara.
Yonago Acta Med, 2017 Jul 14; 60(2). PMID: 28701895    Free PMC article.
Adoptive Cell Therapy of Induced Regulatory T Cells Expanded by Tolerogenic Dendritic Cells on Murine Autoimmune Arthritis.
Jie Yang, Lidong Liu, +4 authors, Rufeng Xie.
J Immunol Res, 2017 Jul 14; 2017. PMID: 28702462    Free PMC article.
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Frida Ewald Sander, Malin Nilsson, +11 authors, Anna Martner.
Cancer Immunol Immunother, 2017 Jul 20; 66(11). PMID: 28721449    Free PMC article.
Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
Cinthia Silva-Vilches, Katrien Pletinckx, +11 authors, Manfred B Lutz.
PLoS One, 2017 Aug 02; 12(7). PMID: 28759565    Free PMC article.
Single-cell RNA sequencing to explore immune cell heterogeneity.
Efthymia Papalexi, Rahul Satija.
Nat Rev Immunol, 2017 Aug 09; 18(1). PMID: 28787399
Highly Cited. Review.
Complement as a regulator of adaptive immunity.
Justin Killick, Gregoire Morisse, Dirk Sieger, Anne L Astier.
Semin Immunopathol, 2017 Aug 27; 40(1). PMID: 28842749    Free PMC article.
Review.
Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.
Esilida Sula Karreci, Siawosh K Eskandari, +18 authors, Jamil Azzi.
JCI Insight, 2017 Nov 03; 2(21). PMID: 29093262    Free PMC article.
Dietary and metabolic modulators of hepatic immunity.
Antonella Carambia, Johannes Herkel.
Semin Immunopathol, 2017 Nov 08; 40(2). PMID: 29110070
Review.
Suppression from beyond the grave.
Yosuke Togashi, Hiroyoshi Nishikawa.
Nat Immunol, 2017 Nov 17; 18(12). PMID: 29144496
Adoptive Induced Antigen-Specific Treg Cells Reverse Inflammation in Collagen-Induced Arthritis Mouse Model.
Guangzhi Sun, Yanfeng Hou, +6 authors, Xinfeng Yan.
Inflammation, 2017 Nov 29; 41(2). PMID: 29181736
Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats.
Hong-Bo Shen, Ze-Jun Huo, +4 authors, Qing-Qing Guo.
Chin J Integr Med, 2017 Dec 22; 24(4). PMID: 29264841
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.
Kimitoshi Kimura, Hirohiko Hohjoh, +7 authors, Takashi Yamamura.
Nat Commun, 2018 Jan 04; 9(1). PMID: 29295981    Free PMC article.
Highly Cited.
Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression.
Hayana Ramos Lima, Thaís Helena Gasparoto, +10 authors, Ana Paula Campanelli.
Front Immunol, 2018 Jan 10; 8. PMID: 29312289    Free PMC article.
Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells.
Partho Sen, Esko Kemppainen, Matej Orešič.
Front Mol Biosci, 2018 Jan 30; 4. PMID: 29376056    Free PMC article.
Review.
Distinct features of dendritic cell-based immunotherapy as cancer vaccines.
Chaelin Lee, Myungmi Lee, Inmoo Rhee.
Clin Exp Vaccine Res, 2018 Feb 06; 7(1). PMID: 29399576    Free PMC article.
Review.
Targeting complement-mediated immunoregulation for cancer immunotherapy.
Martin Kolev, Maciej M Markiewski.
Semin Immunol, 2018 Feb 20; 37. PMID: 29454575    Free PMC article.
Review.
Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB.
Fang Huang, Wei Shao, Koh Fujinaga, B Matija Peterlin.
J Biol Chem, 2018 Feb 22; 293(14). PMID: 29463681    Free PMC article.
MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.
Mingfeng Zhang, Jeremy J Racine, +6 authors, Defu Zeng.
Proc Natl Acad Sci U S A, 2018 Feb 22; 115(10). PMID: 29463744    Free PMC article.
Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.
Mohamed B Ezzelarab, Lien Lu, +2 authors, Angus W Thomson.
Front Immunol, 2018 Mar 10; 9. PMID: 29520267    Free PMC article.
Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice.
Yulin Chen, Jie Wu, +4 authors, Li Zong.
Diabetologia, 2018 Mar 17; 61(6). PMID: 29546475
Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation.
Shi-Bin Cheng, Sarah Davis, Surendra Sharma.
Am J Reprod Immunol, 2018 Mar 27; 79(5). PMID: 29577468    Free PMC article.
Review.
T-cell Dysfunction in Glioblastoma: Applying a New Framework.
Karolina I Woroniecka, Kristen E Rhodin, +2 authors, Peter E Fecci.
Clin Cancer Res, 2018 Mar 30; 24(16). PMID: 29593027    Free PMC article.
Highly Cited. Review.
The short-term stress response - Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity.
Firdaus S Dhabhar.
Front Neuroendocrinol, 2018 Mar 30; 49. PMID: 29596867    Free PMC article.
Review.
Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review).
Xianliang Dai, Li Hua, +7 authors, Chun Liang.
Int J Mol Med, 2018 Apr 06; 42(1). PMID: 29620247    Free PMC article.
Review.
The Role for Exosomal microRNAs in Disruption of Regulatory T Cell Homeostasis in Multiple Sclerosis.
Kimitoshi Kimura, Hirohiko Hohjoh, Takashi Yamamura.
J Exp Neurosci, 2018 Apr 07; 12. PMID: 29623002    Free PMC article.
Functional Defects of Treg Cells: New Targets in Rheumatic Diseases, Including Ankylosing Spondylitis.
Jinlin Miao, Ping Zhu.
Curr Rheumatol Rep, 2018 Apr 18; 20(5). PMID: 29663162
Review.
CD58; leucocyte function adhesion-3 (LFA-3) could be used as a differentiating marker between immune and non-immune thyroid disorders.
Nadia El Menshawy, Mohammed Eissa, +2 authors, Nabil Joseph.
Comp Clin Path, 2018 May 01; 27(3). PMID: 29706856    Free PMC article.
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.
Angelika Schmidt, Francesco Marabita, +15 authors, Jesper Tegnér.
BMC Biol, 2018 May 08; 16(1). PMID: 29730990    Free PMC article.
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Myunghoo Kim, Carolina Galan, +9 authors, Gretchen E Diehl.
Immunity, 2018 Jul 08; 49(1). PMID: 29980437    Free PMC article.
Highly Cited.
Regulatory T cells control epitope spreading in autoimmune arthritis independent of cytotoxic T-lymphocyte antigen-4.
Min Yang, Katrin Klocke, +4 authors, Rikard Holmdahl.
Immunology, 2018 Jul 12; 155(4). PMID: 29992549    Free PMC article.
The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
Tiantian Chen, Xiaoxia Hou, +4 authors, Guochao Shi.
J Immunol Res, 2018 Jul 18; 2018. PMID: 30013989    Free PMC article.
Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation, and Therapeutic Implications.
Shihui Lin, Hua Wu, +2 authors, Fang Xu.
Front Immunol, 2018 Jul 25; 9. PMID: 30038616    Free PMC article.
Review.
Immunological memory cells.
Weronika Ratajczak, Paulina Niedźwiedzka-Rystwej, Beata Tokarz-Deptuła, Wiesław Deptuła.
Cent Eur J Immunol, 2018 Aug 24; 43(2). PMID: 30135633    Free PMC article.
Review.
Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets.
Bhavana Priyadharshini, Michael Loschi, +7 authors, Laurence A Turka.
J Immunol, 2018 Sep 14; 201(8). PMID: 30209190    Free PMC article.
Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial.
Tian Xiao Zhao, Michalis Kostapanos, +11 authors, Ziad Mallat.
BMJ Open, 2018 Sep 19; 8(9). PMID: 30224390    Free PMC article.
Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis.
Hong-Xia Wang, Xia Kang, +5 authors, Weinan Lai.
Exp Ther Med, 2018 Sep 21; 16(4). PMID: 30233732    Free PMC article.
Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment.
Yasuko Tada, Yosuke Togashi, +7 authors, Kohei Shitara.
J Immunother Cancer, 2018 Oct 14; 6(1). PMID: 30314524    Free PMC article.
Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis.
Xiaohua Hao, Yufeng Li, +8 authors, Hongshan Wei.
Front Immunol, 2018 Oct 26; 9. PMID: 30356792    Free PMC article.
The Pivotal Role of Thymus in Atherosclerosis Mediated by Immune and Inflammatory Response.
Xianliang Dai, Danfeng Zhang, +2 authors, Chun Liang.
Int J Med Sci, 2018 Nov 18; 15(13). PMID: 30443178    Free PMC article.
Review.
Bee venom phospholipase A2 ameliorates Alzheimer's disease pathology in Aβ vaccination treatment without inducing neuro-inflammation in a 3xTg-AD mouse model.
Hyunjung Baek, Chan-Ju Lee, +7 authors, Hyunsu Bae.
Sci Rep, 2018 Nov 28; 8(1). PMID: 30478329    Free PMC article.
Decreased regulatory T-cell frequency and interleukin-35 levels in patients with rheumatoid arthritis.
Xia Zhang, Xiaolu Zhang, +4 authors, Ying Liu.
Exp Ther Med, 2018 Dec 14; 16(6). PMID: 30542496    Free PMC article.
Targeting immune cells for cancer therapy.
Sin Yee Gun, Sharon Wei Ling Lee, Je Lin Sieow, Siew Cheng Wong.
Redox Biol, 2019 Mar 29; 25. PMID: 30917934    Free PMC article.
Highly Cited. Review.
Fibroblastic reticular cells at the nexus of innate and adaptive immune responses.
Christian Perez-Shibayama, Cristina Gil-Cruz, Burkhard Ludewig.
Immunol Rev, 2019 Apr 13; 289(1). PMID: 30977192    Free PMC article.
Review.
Differences in immune contextures among different molecular subtypes of gastric cancer and their prognostic impact.
Joo Yeon Kim, Woo Gyeong Kim, Chae Hwa Kwon, Do Youn Park.
Gastric Cancer, 2019 Jun 04; 22(6). PMID: 31152268
Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids.
Akihiro Tokunaga, Daisuke Sugiyama, +7 authors, Hiroyoshi Nishikawa.
J Exp Med, 2019 Sep 21; 216(12). PMID: 31537643    Free PMC article.
Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib.
Elena Maria Elli, Claudia Baratè, +2 authors, Giuseppe Alberto Palumbo.
Front Oncol, 2019 Dec 04; 9. PMID: 31788449    Free PMC article.
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Immune-Monitoring Disease Activity in Primary Membranous Nephropathy.
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Front Med (Lausanne), 2019 Dec 04; 6. PMID: 31788474    Free PMC article.
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Regulatory T cell modulation of cytokine and cellular networks in corneal graft rejection.
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Curr Ophthalmol Rep, 2019 Dec 07; 6(4). PMID: 31807370    Free PMC article.
Reduced GRAMD1C expression correlates to poor prognosis and immune infiltrates in kidney renal clear cell carcinoma.
Haiyan Hao, Ziheng Wang, +4 authors, Wei Wang.
PeerJ, 2019 Dec 26; 7. PMID: 31875150    Free PMC article.
Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.
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Clin Rev Allergy Immunol, 2018 Nov 19; 58(1). PMID: 30449014
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Therapeutic potential of aryl hydrocarbon receptor in autoimmunity.
Xiao-Song Wang, Fan Cao, Yi Zhang, Hai-Feng Pan.
Inflammopharmacology, 2019 Oct 17; 28(1). PMID: 31617124
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Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis.
Constance C Angelou, Alexandria C Wells, +10 authors, Leonid A Pobezinsky.
Front Immunol, 2020 Feb 06; 10. PMID: 32010153    Free PMC article.
Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy.
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Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment.
Kyung Hwan Kim, Joon Young Hur, +9 authors, Eui-Cheol Shin.
Oncoimmunology, 2020 Feb 23; 9(1). PMID: 32076579    Free PMC article.
Characteristics of regulatory T-cell populations before and after Ty21a typhoid vaccination in children and adults.
Mark E Rudolph, Monica A McArthur, +3 authors, Marcelo B Sztein.
Clin Immunol, 2019 Apr 07; 203. PMID: 30953793    Free PMC article.
Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation.
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Front Immunol, 2020 Mar 03; 10. PMID: 32117202    Free PMC article.
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Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model.
Qi Liu, Xiang Wang, +12 authors, Andre E Nel.
ACS Nano, 2019 Apr 10; 13(4). PMID: 30964276    Free PMC article.
Modulation of the immune system by the gut microbiota in the development of type 1 diabetes.
James A Pearson, Andrew Agriantonis, F Susan Wong, Li Wen.
Hum Vaccin Immunother, 2018 Aug 30; 14(11). PMID: 30156993    Free PMC article.
Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications.
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Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4.
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Commun Biol, 2019 May 18; 2. PMID: 31098402    Free PMC article.
A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis.
Adrià Aterido, Juan D Cañete, +15 authors, Antonio Julià.
Front Immunol, 2019 Jul 18; 10. PMID: 31312201    Free PMC article.
Chronic Hepatitis C: Conspectus of immunological events in the course of fibrosis evolution.
Dejan Baskic, Vuk Vukovic, +8 authors, Zeljko Mijailovic.
PLoS One, 2019 Jul 19; 14(7). PMID: 31318916    Free PMC article.
Peripheral blood immune cell-based biomarkers in anti-PD-1/PD-L1 therapy.
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Immune Netw, 2020 Mar 12; 20(1). PMID: 32158596    Free PMC article.
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In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation.
James D Fisher, Wensheng Zhang, +9 authors, Steven R Little.
Sci Adv, 2020 Mar 24; 6(11). PMID: 32201714    Free PMC article.
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Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells.
Tom Eitan Yossipof, Ziva Roy Bazak, +3 authors, Benjamin Sredni.
Front Immunol, 2019 Jun 14; 10. PMID: 31191514    Free PMC article.
The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells.
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Front Immunol, 2019 Apr 27; 10. PMID: 31024539    Free PMC article.
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Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways.
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Theranostics, 2020 Apr 21; 10(11). PMID: 32308767    Free PMC article.
Evolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes.
Olivia Roth, Monica Hongrø Solbakken, +9 authors, Sissel Jentoft.
Proc Natl Acad Sci U S A, 2020 Apr 15; 117(17). PMID: 32284407    Free PMC article.
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.
Fang Bai, Peng Zhang, +6 authors, Kejin Wu.
J Immunother Cancer, 2020 Apr 18; 8(1). PMID: 32300050    Free PMC article.
Role of Regulatory T Cells in Disturbed Immune Homeostasis in Patients With Chronic Obstructive Pulmonary Disease.
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Front Immunol, 2020 May 16; 11. PMID: 32411140    Free PMC article.
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Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation.
Jasminka Z Ilich, Jennifer C Gilman, Selma Cvijetic, Dario Boschiero.
Nutrients, 2020 Apr 08; 12(4). PMID: 32252359    Free PMC article.
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COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence.
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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Henry Kurniawan, Davide G Franchina, +29 authors, Dirk Brenner.
Cell Metab, 2020 Mar 28; 31(5). PMID: 32213345    Free PMC article.
Maternal milk ILCs and adaptive immune cells populate neonatal organs.
Jack C Yu, Hesam Khodadadi, +3 authors, Babak Baban.
Cell Mol Immunol, 2019 Dec 21; 17(6). PMID: 31857705    Free PMC article.
Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds.
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Front Immunol, 2020 Jun 26; 11. PMID: 32582170    Free PMC article.
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Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis.
Isaque Medeiros Siqueira, Marcel Wüthrich, +5 authors, Anamelia Lorenzetti Bocca.
PLoS Negl Trop Dis, 2020 Jun 17; 14(6). PMID: 32542003    Free PMC article.
Structural optimization of a TNFR1-selective antagonistic TNFα mutant to create new-modality TNF-regulating biologics.
Masaki Inoue, Yuta Tsuji, +10 authors, Shin-Ichi Tsunoda.
J Biol Chem, 2020 May 14; 295(28). PMID: 32398258    Free PMC article.
TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer.
Huanhuan Yin, Wei Guo, +3 authors, Yujie Tan.
J Immunol Res, 2020 Sep 24; 2020. PMID: 32964058    Free PMC article.
Current Options and Future Directions in Immune Therapy for Glioblastoma.
John Lynes, Victoria Sanchez, +2 authors, Edjah Nduom.
Front Oncol, 2018 Dec 21; 8. PMID: 30568917    Free PMC article.
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Increased frequency of regulatory T cells in the peripheral blood of patients with endometrioid adenocarcinoma.
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Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial.
William Camu, Marius Mickunas, +18 authors, Gilbert Bensimon.
EBioMedicine, 2020 Jul 12; 59. PMID: 32651161    Free PMC article.
The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations.
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Front Immunol, 2020 Oct 20; 11. PMID: 33072105    Free PMC article.
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Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
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Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.
Julia Pagel, Nele Twisselmann, +12 authors, Christoph Härtel.
Front Immunol, 2020 Oct 27; 11. PMID: 33101284    Free PMC article.
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions.
Guoming Zeng, Libo Jin, +9 authors, Da Sun.
Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116895    Free PMC article.
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Re-Examining the Role of TNF in MS Pathogenesis and Therapy.
Diego Fresegna, Silvia Bullitta, +14 authors, Antonietta Gentile.
Cells, 2020 Oct 18; 9(10). PMID: 33066433    Free PMC article.
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DCAF1 regulates Treg senescence via the ROS axis during immunological aging.
Zengli Guo, Gang Wang, +9 authors, Yisong Y Wan.
J Clin Invest, 2020 Jul 31; 130(11). PMID: 32730228    Free PMC article.
IL-4Rα signaling in CD4+CD25+FoxP3+ T regulatory cells restrains airway inflammation via limiting local tissue IL-33.
Jermaine Khumalo, Frank Kirstein, Sabelo Hadebe, Frank Brombacher.
JCI Insight, 2020 Sep 16; 5(20). PMID: 32931477    Free PMC article.
Adoptive transfer of TILs plus anti-PD1 therapy: An alternative combination therapy for treating metastatic osteosarcoma.
Chao Wang, Ming Li, Rong Wei, Junlong Wu.
J Bone Oncol, 2020 Nov 05; 25. PMID: 33145154    Free PMC article.
Ipilimumab in prostate cancer.
Nishith Singh, Ravi A Madan, James L Gulley.
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IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity.
Hidekazu Shirota, Dennis M Klinman, +3 authors, Chikashi Ishioka.
Cancer Immunol Res, 2016 Dec 07; 5(1). PMID: 27920023    Free PMC article.
Cross-Domain and Viral Interactions in the Microbiome.
Aislinn D Rowan-Nash, Benjamin J Korry, Eleftherios Mylonakis, Peter Belenky.
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<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity.
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Nagoya J Med Sci, 2019 Apr 10; 81(1). PMID: 30962651    Free PMC article.
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mTOR and Aging: An Old Fashioned Dress.
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Applications of Single-Cell Omics to Dissect Tumor Microenvironment.
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Front Genet, 2020 Dec 18; 11. PMID: 33329692    Free PMC article.
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Vaccination in Atherosclerosis.
Felix Sebastian Nettersheim, Lauren De Vore, Holger Winkels.
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Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer.
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Eur J Immunol, 2020 Oct 18; 50(11). PMID: 33067808    Free PMC article.
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Immunopathobiology and therapeutic targets related to cytokines in liver diseases.
Yong He, Seonghwan Hwang, +7 authors, Bin Gao.
Cell Mol Immunol, 2020 Nov 19; 18(1). PMID: 33203939    Free PMC article.
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COVID-19: High-JAKing of the Inflammatory "Flight" by Ruxolitinib to Avoid the Cytokine Storm.
Cirino Botta, Alessia Indrieri, +7 authors, Francesco Mendicino.
Front Oncol, 2021 Jan 26; 10. PMID: 33489899    Free PMC article.
Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function.
Xiaoxia Wang, Hao Cheng, Yige Shen, Bin Li.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523444
Regulatory T Cells for the Induction of Transplantation Tolerance.
Weitao Que, Xiao-Kang Li.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523454
Current Advances in Immunotherapy for Glioblastoma.
Abigail L Mende, Jessica D Schulte, Hideho Okada, Jennifer L Clarke.
Curr Oncol Rep, 2021 Jan 27; 23(2). PMID: 33496872    Free PMC article.
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Immune suppression in gliomas.
Matthew M Grabowski, Eric W Sankey, +4 authors, Peter E Fecci.
J Neurooncol, 2020 Jun 17; 151(1). PMID: 32542437    Free PMC article.
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Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development.
Sara Rocha, Afonso P Basto, +13 authors, Carla Oliveira.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33498681    Free PMC article.
Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
Magdy Elnashar, Mauro Vaccarezza, Hani Al-Salami.
Future Sci OA, 2021 Feb 09; 7(3). PMID: 33552541    Free PMC article.
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Inflammatory Dendritic Cells Contribute to Regulate the Immune Response in Sickle Cell Disease.
Renata Sesti-Costa, Marina Dorigatti Borges, +3 authors, Fernando Ferreira Costa.
Front Immunol, 2021 Feb 23; 11. PMID: 33613546    Free PMC article.
A novel potential target of IL-35-regulated JAK/STAT signaling pathway in lupus nephritis.
Zhe Cai, Song Zhang, +7 authors, Huasong Zeng.
Clin Transl Med, 2021 Feb 27; 11(2). PMID: 33634995    Free PMC article.
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Yun-Shiuan Olivia Hsu, Kun-Lin Lu, +8 authors, Chun-Bing Chen.
Front Immunol, 2021 Mar 16; 12. PMID: 33717075    Free PMC article.
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Biomechanics of T Cell Dysfunctions in Chronic Diseases.
Sachith D Gunasinghe, Newton G Peres, Jesse Goyette, Katharina Gaus.
Front Immunol, 2021 Mar 16; 12. PMID: 33717081    Free PMC article.
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Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation.
Brett E Phillips, Yesica Garciafigueroa, +6 authors, Nick Giannoukakis.
Front Immunol, 2021 Mar 26; 12. PMID: 33763059    Free PMC article.
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Navid Sobhani, Dana Rae Tardiel-Cyril, +3 authors, Yong Li.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809974    Free PMC article.
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Deep generative selection models of T and B cell receptor repertoires with soNNia.
Giulio Isacchini, Aleksandra M Walczak, Thierry Mora, Armita Nourmohammad.
Proc Natl Acad Sci U S A, 2021 Apr 03; 118(14). PMID: 33795515    Free PMC article.
Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases.
Hanna Graßhoff, Sara Comdühr, +4 authors, Jens Y Humrich.
Front Immunol, 2021 Apr 20; 12. PMID: 33868284    Free PMC article.
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Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.
Michelle Rosenzwajg, Guillaume Churlaud, +13 authors, David Klatzmann.
J Autoimmun, 2015 Jan 31; 58. PMID: 25634360    Free PMC article.
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HIV persistence in subsets of CD4+ T cells: 50 shades of reservoirs.
Rémi Fromentin, Nicolas Chomont.
Semin Immunol, 2020 Dec 05; 51. PMID: 33272901    Free PMC article.
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Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes.
Saeed Mohammadian Haftcheshmeh, Arezou Khosrojerdi, +3 authors, Amir Abbas Momtazi-Borojeni.
Rev Physiol Biochem Pharmacol, 2021 Jan 07; 179. PMID: 33404796
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Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities.
Qian Yin, Wong Yu, +12 authors, Mark M Davis.
Proc Natl Acad Sci U S A, 2021 May 23; 118(21). PMID: 34021082    Free PMC article.
Immune checkpoint blockade impairs immunosuppressive mechanisms of regulatory T cells in B-cell lymphoma.
Vera Bauer, Fatima Ahmetlić, +3 authors, Ralph Mocikat.
Transl Oncol, 2021 Jul 07; 14(9). PMID: 34229208    Free PMC article.
Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus.
Sean Robinson, Ranjeny Thomas.
Front Immunol, 2021 Aug 03; 12. PMID: 34335564    Free PMC article.
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Oncolytic Viruses for Malignant Glioma: On the Verge of Success?
Yogesh R Suryawanshi, Autumn J Schulze.
Viruses, 2021 Aug 11; 13(7). PMID: 34372501    Free PMC article.
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Interleukin-30 Suppresses Not Only CD4+ T Cells but Also Regulatory T Cells in Murine Primary Biliary Cholangitis.
Hung-Wen Chen, Chia-I Lin, Ya-Hui Chuang.
Biomedicines, 2021 Aug 28; 9(8). PMID: 34440235    Free PMC article.
Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice.
Sushmita Negi, Sheetal Saini, +3 authors, Rajeev K Tyagi.
Cells, 2021 Aug 28; 10(8). PMID: 34440615    Free PMC article.
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Aptamer-mediated transcriptional gene silencing of Fox p 3 inhibits regulatory T cells and potentiates antitumor response.
Andrea J Manrique-Rincón, Luciana P Ruas, +6 authors, Marcio C Bajgelman.
Mol Ther Nucleic Acids, 2021 Aug 31; 25. PMID: 34457999    Free PMC article.
Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells.
Ingrid Safina, Zeid A Nima Al Sudani, +5 authors, Kieng Bao Vang.
PLoS One, 2021 Aug 31; 16(8). PMID: 34460818    Free PMC article.
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities.
Umar Mehraj, Rais A Ganai, +10 authors, Nissar Ahmad Wani.
Cell Oncol (Dordr), 2021 Sep 17; 44(6). PMID: 34528143
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Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives.
Shuntaro Ikegawa, Ken-Ichi Matsuoka.
Front Immunol, 2021 Sep 17; 12. PMID: 34526990    Free PMC article.
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K2P18.1 translates T cell receptor signals into thymic regulatory T cell development.
Tobias Ruck, Stefanie Bock, +35 authors, Sven G Meuth.
Cell Res, 2021 Oct 28; 32(1). PMID: 34702947    Free PMC article.
Intranuclear Delivery of HIF-1α-TMD Alleviates EAE via Functional Conversion of TH17 Cells.
Jin-Su Shin, Ilkoo Kim, +4 authors, Sang-Kyou Lee.
Front Immunol, 2021 Nov 09; 12. PMID: 34745114    Free PMC article.
Chronic Refractory Immune Thrombocytopenia Is Associated With Variants in Immune Genes.
Shasha Zhao, Jingyao Ma, +2 authors, Runhui Wu.
Clin Appl Thromb Hemost, 2021 Nov 18; 27. PMID: 34786962    Free PMC article.
A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells.
Viviana Volta, Sandra Pérez-Baos, +4 authors, Robert J Schneider.
Nat Commun, 2021 Dec 02; 12(1). PMID: 34848685    Free PMC article.
Immune Dysregulation and Infectious Complications in MPN Patients Treated With JAK Inhibitors.
Daniele Cattaneo, Alessandra Iurlo.
Front Immunol, 2021 Dec 07; 12. PMID: 34867980    Free PMC article.
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Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer.
Jianyu Liu, Xueying Wang, +3 authors, Zhigao Li.
Front Oncol, 2021 Dec 07; 11. PMID: 34868991    Free PMC article.
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Identification of an Autophagy-Related Gene Signature for the Prediction of Prognosis in Early-Stage Colorectal Cancer.
Xu-Tao Lin, Qiu-Ning Wu, +8 authors, Feng Gao.
Front Genet, 2021 Dec 14; 12. PMID: 34899841    Free PMC article.
Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors.
Takuro Saito, Koji Kurose, +11 authors, Hisashi Wada.
Nagoya J Med Sci, 2021 Dec 18; 83(4). PMID: 34916725    Free PMC article.
The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries.
Naveena B Janakiram, Michael S Valerio, Stephen M Goldman, Christopher L Dearth.
Int J Mol Sci, 2021 Dec 25; 22(24). PMID: 34948349    Free PMC article.
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SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women.
Li-En Hsieh, Alba Grifoni, +6 authors, Alessandra Franco.
J Reprod Immunol, 2021 Dec 26; 149. PMID: 34953325    Free PMC article.
CD4+ T Cells Promote IgG Production in MHC-Independent and ICAM-1-Dependent Manners in Pristane-Induced Lupus Mice.
Shuai Liu, Yu-Mei Li, +4 authors, Ying Wang.
Mediators Inflamm, 2022 Feb 01; 2022. PMID: 35095344    Free PMC article.
Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes.
Kunfeng Bai, Cheuk-Lun Lee, +12 authors, Philip C N Chiu.
J Nanobiotechnology, 2022 Feb 20; 20(1). PMID: 35180876    Free PMC article.
HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis.
Chuanhong Zhong, Bei Tao, +7 authors, Xiaobo Yang.
Cell Death Dis, 2022 Feb 20; 13(2). PMID: 35181676    Free PMC article.
Tumor-infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma.
Tomio Hayashi, Kazuhiro Yoshikawa, +3 authors, Yoshiaki Kazaoka.
Clin Exp Dent Res, 2021 Jul 29; 8(1). PMID: 34319010    Free PMC article.
A Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives.
Zhongyu Han, Kuai Ma, +8 authors, Chi Liu.
Front Immunol, 2022 Mar 08; 13. PMID: 35251009    Free PMC article.
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Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion.
Xiaofei Gao, Yang Song, +4 authors, Ming Zhao.
Front Immunol, 2022 Mar 18; 13. PMID: 35296076    Free PMC article.
Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma.
Xin Zhou, Jia-Mi Huang, +7 authors, Tao Peng.
Front Genet, 2022 Mar 29; 13. PMID: 35342392    Free PMC article.
Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders - Advances and challenges.
Tapas Kumar Goswami, Mithilesh Singh, +7 authors, Kuldeep Dhama.
Hum Vaccin Immunother, 2022 Mar 05; 18(1). PMID: 35240914    Free PMC article.
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Chimeric Antigen Receptor (CAR) T Cell Therapy for Glioblastoma.
Amitesh Verma, Sarwish Rafiq.
Cancer Treat Res, 2022 May 14; 183. PMID: 35551659
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Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes.
Farhan Ullah Khan, Puregmaa Khongorzul, +3 authors, Abdelaziz Amrani.
Int J Mol Sci, 2022 May 15; 23(9). PMID: 35563276    Free PMC article.
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Modulation of Mismatch Repair and the SOCS1/p53 Axis by microRNA-155 in the Colon of Patients with Primary Sclerosing Cholangitis.
Monika Adamowicz, Iga Stukan, +3 authors, Agnieszka Kempinska-Podhorodecka.
Int J Mol Sci, 2022 May 15; 23(9). PMID: 35563301    Free PMC article.