Journal Article
. 2010 Feb; 184(6):3106-16.
doi: 10.4049/jimmunol.0902661.

Mechanism of T cell tolerance induced by myeloid-derived suppressor cells

Srinivas Nagaraj 1 Adam G Schrum  Hyun-Il Cho  Esteban Celis  Dmitry I Gabrilovich  
Affiliations
  • PMID: 20142361
  •     38 References
  •     182 citations

Abstract

Ag-specific T cell tolerance plays a critical role in tumor escape. Recent studies implicated myeloid-derived suppressor cells (MDSCs) in the induction of CD8(+) T cell tolerance in tumor-bearing hosts. However, the mechanism of this phenomenon remained unclear. We have found that incubation of Ag-specific CD8(+) T cells, with peptide-loaded MDSCs, did not induce signaling downstream of TCR. However, it prevented subsequent signaling from peptide-loaded dendritic cells. Using double TCR transgenic CD8(+) T cells, we have demonstrated that MDSC induced tolerance to only the peptide, which was presented by MDSCs. T cell response to the peptide specific to the other TCR was not affected. Incubation of MDSCs with Ag-specific CD8(+) T cells caused nitration of the molecules on the surface of CD8(+) T cells, localized to the site of physical interaction between MDSC and T cells, which involves preferentially only TCR specific for the peptide presented by MDSCs. Postincubation with MDSCs, only nitrotyrosine-positive CD8(+) T cells demonstrated profound nonresponsiveness to the specific peptide, whereas nitrotyrosine-negative CD8(+) T cells responded normally to that stimulation. MDSCs caused dissociation between TCR and CD3zeta molecules, disrupting TCR complexes on T cells. Thus, these data describe a novel mechanism of Ag-specific CD8(+) T cell tolerance in cancer.

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World J Surg Oncol, 2015 Oct 02; 13. PMID: 26424708    Free PMC article.
Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area.
A Marijne Heeren, Eline de Boer, +5 authors, Ekaterina S Jordanova.
Oncotarget, 2015 Oct 03; 6(32). PMID: 26431490    Free PMC article.
Paving the Road to Tumor Development and Spreading: Myeloid-Derived Suppressor Cells are Ruling the Fate.
Yaron Meirow, Julia Kanterman, Michal Baniyash.
Front Immunol, 2015 Nov 04; 6. PMID: 26528286    Free PMC article.
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The prognostic effects of tumor infiltrating regulatory T cells and myeloid derived suppressor cells assessed by multicolor flow cytometry in gastric cancer patients.
Han Sol Choi, Sang Yun Ha, +9 authors, Eun-Suk Kang.
Oncotarget, 2016 Jan 23; 7(7). PMID: 26799288    Free PMC article.
Neutrophils in Cancer: Two Sides of the Same Coin.
Eileen Uribe-Querol, Carlos Rosales.
J Immunol Res, 2016 Jan 29; 2015. PMID: 26819959    Free PMC article.
Highly Cited. Review.
Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.
Celeste C Goh, Krystal M Roggerson, +3 authors, Young S Hahn.
J Immunol, 2016 Jan 31; 196(5). PMID: 26826241    Free PMC article.
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.
Vinit Kumar, Sima Patel, Evgenii Tcyganov, Dmitry I Gabrilovich.
Trends Immunol, 2016 Feb 10; 37(3). PMID: 26858199    Free PMC article.
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Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors.
Ying Zhang, Hildegund C J Ertl.
Oncotarget, 2016 Mar 05; 7(17). PMID: 26943036    Free PMC article.
Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment.
Jaehong Kim, Jong-Sup Bae.
Mediators Inflamm, 2016 Mar 12; 2016. PMID: 26966341    Free PMC article.
Highly Cited. Review.
Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC).
Cesarina Giallongo, Daniele Tibullo, +10 authors, Francesco Di Raimondo.
Oncotarget, 2016 Mar 12; 7(52). PMID: 26967390    Free PMC article.
Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy.
Inès Dufait, Els Van Valckenborgh, +3 authors, Karine Breckpot.
Oncotarget, 2016 Mar 31; 7(27). PMID: 27029037    Free PMC article.
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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.
Timothy M Nywening, Andrea Wang-Gillam, +18 authors, David C Linehan.
Lancet Oncol, 2016 Apr 09; 17(5). PMID: 27055731    Free PMC article.
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Melanoma exosomes enable tumor tolerance in lymph nodes.
Joshua L Hood.
Med Hypotheses, 2016 Apr 12; 90. PMID: 27063077    Free PMC article.
Myeloid-Derived Suppressor Cells in Bacterial Infections.
Michael Ost, Anurag Singh, +3 authors, Dominik Hartl.
Front Cell Infect Microbiol, 2016 Apr 12; 6. PMID: 27066459    Free PMC article.
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The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury.
Mili Mandal, Carol R Gardner, +5 authors, Debra L Laskin.
Toxicol Appl Pharmacol, 2016 May 11; 304. PMID: 27163765    Free PMC article.
Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Ruth J Davis, Carter Van Waes, Clint T Allen.
Oral Oncol, 2016 May 25; 58. PMID: 27215705    Free PMC article.
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Cryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation.
Jun Zhu, Yan Zhang, +3 authors, Lisa X Xu.
Sci Rep, 2016 Jun 04; 6. PMID: 27256519    Free PMC article.
The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications.
Panagiota Economopoulou, Christos Perisanidis, Evaggelos I Giotakis, Amanda Psyrri.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275486    Free PMC article.
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.
Vincenzo Bronte, Sven Brandau, +12 authors, Dmitry I Gabrilovich.
Nat Commun, 2016 Jul 07; 7. PMID: 27381735    Free PMC article.
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Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients.
Cesarina Giallongo, Alessandra Romano, +9 authors, Francesco Di Raimondo.
PLoS One, 2016 Jul 09; 11(7). PMID: 27391078    Free PMC article.
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice.
Dominic Schmidt, Daniel Peterlik, +2 authors, Daniela N Männel.
PLoS One, 2016 Jul 09; 11(7). PMID: 27391954    Free PMC article.
Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes.
Joshua L Hood.
Med Hypotheses, 2016 Aug 16; 94. PMID: 27515216    Free PMC article.
Monitoring of the Immune Dysfunction in Cancer Patients.
Saskia J A M Santegoets, Marij J P Welters, Sjoerd H van der Burg.
Vaccines (Basel), 2016 Sep 07; 4(3). PMID: 27598210    Free PMC article.
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Sunitinib: the antiangiogenic effects and beyond.
Zhonglin Hao, Ibrahim Sadek.
Onco Targets Ther, 2016 Sep 24; 9. PMID: 27660467    Free PMC article.
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Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy.
Neha Kamran, Mayuri Chandran, Pedro R Lowenstein, Maria G Castro.
Clin Immunol, 2016 Nov 04; 189. PMID: 27777083    Free PMC article.
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One microenvironment does not fit all: heterogeneity beyond cancer cells.
Ik Sun Kim, Xiang H-F Zhang.
Cancer Metastasis Rev, 2016 Nov 20; 35(4). PMID: 27858305    Free PMC article.
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Improved Antitumor Activity of a Therapeutic Melanoma Vaccine through the Use of the Dual COX-2/5-LO Inhibitor Licofelone.
Silke Neumann, Simon A Shirley, Roslyn A Kemp, Sarah M Hook.
Front Immunol, 2016 Dec 21; 7. PMID: 27994586    Free PMC article.
IL-6 Improves the Nitric Oxide-Induced Cytotoxic CD8+ T Cell Dysfunction in Human Chagas Disease.
Liliana Maria Sanmarco, Laura Marina Visconti, +8 authors, Maria Pilar Aoki.
Front Immunol, 2017 Jan 10; 7. PMID: 28066435    Free PMC article.
Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype.
Fanping Kong, Omar A Saldarriaga, +4 authors, Peter C Melby.
PLoS Pathog, 2017 Feb 01; 13(1). PMID: 28141856    Free PMC article.
Tumor regression is mediated via the induction of HER263-71- specific CD8+ CTL activity in a 4T1.2/HER2 tumor model: no involvement of CD80 in tumor control.
Sayyed Nilofar Danishmalik, Si-Hyeong Lee, Jeong-Im Sin.
Oncotarget, 2017 May 04; 8(16). PMID: 28460461    Free PMC article.
Phenotype and Function of Myeloid-Derived Suppressor Cells Induced by Porphyromonas gingivalis Infection.
Lingkai Su, Qingan Xu, +2 authors, Jannet Katz.
Infect Immun, 2017 May 24; 85(8). PMID: 28533469    Free PMC article.
Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection.
Malgorzata Drabczyk-Pluta, Tanja Werner, +4 authors, Gennadiy Zelinskyy.
Retrovirology, 2017 Aug 25; 14(1). PMID: 28835242    Free PMC article.
Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma.
Hiroshi Kobayashi, Tomotake Okuma, +11 authors, Sakae Tanaka.
Int J Clin Oncol, 2017 Nov 01; 23(2). PMID: 29086877
Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration.
Joseph Markowitz, Jiang Wang, +14 authors, William E Carson.
Sci Rep, 2017 Nov 15; 7(1). PMID: 29133913    Free PMC article.
Re-balance of memory T cell subsets in peripheral blood from patients with CML after TKI treatment.
Danlin Yao, Ling Xu, +12 authors, Yangqiu Li.
Oncotarget, 2017 Nov 16; 8(47). PMID: 29137227    Free PMC article.
Monocytic myeloid-derived suppressor cells as prognostic factor in chronic myeloid leukaemia patients treated with dasatinib.
Cesarina Giallongo, Nunziatina L Parrinello, +9 authors, Francesco Di Raimondo.
J Cell Mol Med, 2017 Dec 09; 22(2). PMID: 29218828    Free PMC article.
Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells.
Hiroaki Shime, Akira Maruyama, +3 authors, Tsukasa Seya.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296526    Free PMC article.
Loss of Muscle Mass is a Novel Predictor of Postoperative Early Recurrence in N2-Positive Non-Small-Cell Lung Cancer.
Takuma Tsukioka, Nobuhiro Izumi, +4 authors, Noritoshi Nishiyama.
Ann Thorac Cardiovasc Surg, 2018 Feb 21; 24(3). PMID: 29459570    Free PMC article.
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Carlos Rosales.
Front Physiol, 2018 Mar 09; 9. PMID: 29515456    Free PMC article.
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Role of Polyamines in Immune Cell Functions.
Rebecca S Hesterberg, John L Cleveland, Pearlie K Epling-Burnette.
Med Sci (Basel), 2018 Mar 09; 6(1). PMID: 29517999    Free PMC article.
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The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
Kimberly M Arnold, Nicole J Flynn, +5 authors, Jennifer Sims-Mourtada.
Cancer Growth Metastasis, 2018 Mar 20; 11. PMID: 29551910    Free PMC article.
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Under-Evaluated or Unassessed Pathogenic Pathways in Autoimmune Hepatitis and Implications for Future Management.
Albert J Czaja.
Dig Dis Sci, 2018 Apr 20; 63(7). PMID: 29671161
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Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas.
Hiromi Sasaki, Satoshi Nagano, +2 authors, Takao Setoguchi.
Nutrients, 2018 Jun 15; 10(6). PMID: 29899304    Free PMC article.
The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma.
Demi S Houg, Maarten F Bijlsma.
Mol Cancer, 2018 Jun 16; 17(1). PMID: 29903049    Free PMC article.
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Positive correlation between sarcopenia and elevation of neutrophil/lymphocyte ratio in pathological stage IIIA (N2-positive) non-small cell lung cancer patients.
Takuma Tsukioka, Nobuhiro Izumi, +6 authors, Noritoshi Nishiyama.
Gen Thorac Cardiovasc Surg, 2018 Aug 15; 66(12). PMID: 30105630
Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer.
Julie G Grossman, Timothy M Nywening, +7 authors, Ryan C Fields.
Oncoimmunology, 2018 Sep 20; 7(9). PMID: 30228938    Free PMC article.
Hematopoietic stem cell specific V-ATPase controls breast cancer progression and metastasis via cytotoxic T cells.
Manoranjan Sahoo, Gajendra K Katara, +5 authors, Kenneth D Beaman.
Oncotarget, 2018 Sep 22; 9(69). PMID: 30237863    Free PMC article.
Monocyte glycolysis determines CD8+ T cell functionality in human Chagas disease.
Liliana María Sanmarco, Natalia Eberhardt, +9 authors, Maria Pilar Aoki.
JCI Insight, 2019 Sep 04; 4(18). PMID: 31479429    Free PMC article.
Pretreatment Inflammatory Indexes as Prognostic Predictors of Survival in Patients Suffering From Synovial Sarcoma.
Yuan Cheng, Fei Mo, +2 authors, Xuelei Ma.
Front Oncol, 2019 Oct 15; 9. PMID: 31608240    Free PMC article.
Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies.
Giuseppe Alberto Palumbo, Nunziatina Laura Parrinello, +8 authors, Alessandra Romano.
Int J Mol Sci, 2019 Nov 07; 20(21). PMID: 31683978    Free PMC article.
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Destress and do not suppress: targeting adrenergic signaling in tumor immunosuppression.
Ignacio Iñigo-Marco, Marta M Alonso.
J Clin Invest, 2019 Nov 12; 129(12). PMID: 31710309    Free PMC article.
Myeloid-derived suppressor cells-new and exciting players in lung cancer.
Zhenzhen Yang, Jiacheng Guo, +3 authors, Wang Ma.
J Hematol Oncol, 2020 Feb 02; 13(1). PMID: 32005273    Free PMC article.
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Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats.
Soumyabrata Munshi, Maxine K Loh, +6 authors, J Amiel Rosenkranz.
Brain Behav Immun, 2019 Dec 01; 84. PMID: 31785394    Free PMC article.
Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.
Junko Masuda, Eiji Takayama, +16 authors, Masaharu Seno.
Oncol Rep, 2017 May 24; 38(1). PMID: 28535011    Free PMC article.
The Yin and Yang of Myeloid Derived Suppressor Cells.
Snehil Budhwar, Priyanka Verma, +2 authors, Kiran Singh.
Front Immunol, 2018 Dec 18; 9. PMID: 30555467    Free PMC article.
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Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model.
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Cell Commun Signal, 2019 Apr 14; 17(1). PMID: 30979375    Free PMC article.
Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice.
Tomohiro Kawano, Munehisa Shimamura, +3 authors, Hideki Mochizuki.
PLoS One, 2019 May 03; 14(5). PMID: 31048856    Free PMC article.
A Bump in the Road: How the Hostile AML Microenvironment Affects CAR T Cell Therapy.
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Front Oncol, 2020 Mar 19; 10. PMID: 32185132    Free PMC article.
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Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer.
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J Immunol, 2019 Aug 21; 203(5). PMID: 31427398    Free PMC article.
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Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment.
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Cancer Biol Med, 2020 Apr 17; 17(1). PMID: 32296575    Free PMC article.
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The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment.
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Front Immunol, 2020 May 12; 11. PMID: 32391020    Free PMC article.
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The emerging role of epigenetic therapeutics in immuno-oncology.
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Nat Rev Clin Oncol, 2019 Sep 25; 17(2). PMID: 31548600    Free PMC article.
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Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction.
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JCI Insight, 2019 Jun 07; 4(11). PMID: 31167966    Free PMC article.
CCL2/CCR2 signaling in cancer pathogenesis.
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Cell Commun Signal, 2020 May 31; 18(1). PMID: 32471499    Free PMC article.
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Immune Evasion by Head and Neck Cancer: Foundations for Combination Therapy.
Joshua D Horton, Hannah M Knochelmann, +2 authors, David M Neskey.
Trends Cancer, 2019 Apr 10; 5(4). PMID: 30961829    Free PMC article.
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Cell interactions in the bone marrow microenvironment affecting myeloid malignancies.
Konstantinos D Kokkaliaris, David T Scadden.
Blood Adv, 2020 Aug 12; 4(15). PMID: 32780848    Free PMC article.
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation.
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Front Immunol, 2020 Aug 15; 11. PMID: 32793192    Free PMC article.
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Myeloid-Derived Suppressor Cells in Colorectal Cancer.
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Front Immunol, 2020 Aug 28; 11. PMID: 32849517    Free PMC article.
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Negative regulation of myeloid-derived suppressor cells in cancer.
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The Sweet Surrender: How Myeloid Cell Metabolic Plasticity Shapes the Tumor Microenvironment.
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Front Cell Dev Biol, 2019 Jan 09; 6. PMID: 30619850    Free PMC article.
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The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma.
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J Oncol, 2019 Jan 22; 2018. PMID: 30662462    Free PMC article.
Myeloid-Derived Suppressor Cells Promote Metastasis in Breast Cancer After the Stress of Operative Removal of the Primary Cancer.
Xuelei Ma, Manni Wang, +2 authors, Xiawei Wei.
Front Oncol, 2019 Sep 26; 9. PMID: 31552179    Free PMC article.
Poly(cyclodextrin)-Polydrug Nanocomplexes as Synthetic Oncolytic Virus for Locoregional Melanoma Chemoimmunotherapy.
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Adv Funct Mater, 2020 Oct 20; 30(16). PMID: 33071710    Free PMC article.
The Development and Homing of Myeloid-Derived Suppressor Cells: From a Two-Stage Model to a Multistep Narrative.
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Front Immunol, 2020 Nov 17; 11. PMID: 33193327    Free PMC article.
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Immune suppression: the hallmark of myeloid derived suppressor cells.
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Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration.
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FEBS J, 2018 Feb 06; 285(6). PMID: 29399967    Free PMC article.
The Expression of CD74-Regulated Inflammatory Markers in Stage IV Melanoma: Risk of CNS Metastasis and Patient Survival.
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Cancers (Basel), 2020 Dec 18; 12(12). PMID: 33327409    Free PMC article.
Defects at the Posttranscriptional Level Account for the Low TCRζ Chain Expression Detected in Gastric Cancer Independently of Caspase-3 Activity.
Ana Aguinaga-Barrilero, Patricia Castro-Sánchez, +5 authors, José M Martin-Villa.
J Immunol Res, 2020 Dec 24; 2020. PMID: 33354577    Free PMC article.
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Cancer Metastasis Rev, 2021 Jan 08; 40(2). PMID: 33411082
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Correlation analysis of the proportion of monocytic myeloid-derived suppressor cells in colorectal cancer patients.
Kenna Shirasuna, Masayuki Ito, +6 authors, Sadao Kuromitsu.
PLoS One, 2020 Dec 29; 15(12). PMID: 33370317    Free PMC article.
Molecular Mechanisms of Treatment Resistance in Glioblastoma.
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The Potential of T Cell Factor 1 in Sustaining CD8+ T Lymphocyte-Directed Anti-Tumor Immunity.
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Cancers (Basel), 2021 Feb 13; 13(3). PMID: 33572793    Free PMC article.
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Circulating Myeloid Regulatory Cells: Promising Biomarkers in B-Cell Lymphomas.
Juliette Ferrant, Faustine Lhomme, +2 authors, Mikael Roussel.
Front Immunol, 2021 Feb 20; 11. PMID: 33603754    Free PMC article.
Novel Combinatorial Approaches to Tackle the Immunosuppressive Microenvironment of Prostate Cancer.
Erin G Shackleton, Haleema Yoosuf Ali, +2 authors, Stephanie E McArdle.
Cancers (Basel), 2021 Apr 04; 13(5). PMID: 33800156    Free PMC article.
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Prognostic significance of S100A8-positive immune cells in relation to other immune cell infiltration in pre-invasive and invasive breast cancers.
Ji Won Woo, Yul Ri Chung, +3 authors, So Yeon Park.
Cancer Immunol Immunother, 2020 Nov 05; 70(5). PMID: 33146829    Free PMC article.
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment.
Jennifer Frosch, Ilia Leontari, John Anderson.
Cancers (Basel), 2021 May 01; 13(7). PMID: 33917501    Free PMC article.
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Immunosuppressive Myeloid Cells Induce Nitric Oxide-Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells.
Adam N R Cartwright, Shengbao Suo, +8 authors, Kai W Wucherpfennig.
Cancer Immunol Res, 2021 Jan 31; 9(4). PMID: 33514509    Free PMC article.
Myeloid-Derived Suppressor Cells as Therapeutic Targets in Uterine Cervical and Endometrial Cancers.
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Cells, 2021 May 06; 10(5). PMID: 33946532    Free PMC article.
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Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells.
Jiaying Liu, Randall Toy, +17 authors, Krishnendu Roy.
Nano Lett, 2021 Jan 05; 21(1). PMID: 33395313    Free PMC article.
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy.
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Cells, 2021 Jun 03; 10(5). PMID: 34065010    Free PMC article.
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Immune-Related Gene SERPINE1 Is a Novel Biomarker for Diffuse Lower-Grade Gliomas via Large-Scale Analysis.
Xiaoming Huang, Fenglin Zhang, +6 authors, Tao Xin.
Front Oncol, 2021 Jun 08; 11. PMID: 34094933    Free PMC article.
Repression of MUC1 Promotes Expansion and Suppressive Function of Myeloid-Derived Suppressor Cells in Pancreatic and Breast Cancer Murine Models.
Mahnaz Sahraei, Mukulika Bose, +5 authors, Pinku Mukherjee.
Int J Mol Sci, 2021 Jun 03; 22(11). PMID: 34070449    Free PMC article.
Myeloid-Derived Suppressor Cells and Mesenchymal Stem/Stromal Cells in Myeloid Malignancies.
Suncica Kapor, Juan F Santibanez.
J Clin Med, 2021 Jul 03; 10(13). PMID: 34202907    Free PMC article.
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Preoperative Immunotherapy in the Multidisciplinary Management of Oral Cavity Cancer.
Ramez Philips, Chihun Han, +4 authors, Jennifer Johnson.
Front Oncol, 2021 Jul 20; 11. PMID: 34277428    Free PMC article.
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Chemotherapy: a double-edged sword in cancer treatment.
Nafiseh Behranvand, Farzad Nasri, +4 authors, Reza Falak.
Cancer Immunol Immunother, 2021 Aug 07; 71(3). PMID: 34355266
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Receptor Tyrosine Kinase Inhibitor Sunitinib as Novel Immunotherapy to Inhibit Myeloid-Derived Suppressor Cells for Treatment of Endometriosis.
Ying He, Sze Wan Hung, +7 authors, Chi Chiu Wang.
Front Immunol, 2021 Aug 10; 12. PMID: 34367125    Free PMC article.
Advances of Tumorigenesis, Diagnosis at Early Stage, and Cellular Immunotherapy in Gastrointestinal Malignancies.
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Front Oncol, 2021 Aug 27; 11. PMID: 34434889    Free PMC article.
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Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis.
Vinzeigh N Leukes, Anca Dorhoi, +5 authors, Nelita du Plessis.
Cell Immunol, 2021 Apr 18; 364. PMID: 33865151    Free PMC article.
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer.
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Signal Transduct Target Ther, 2021 Oct 09; 6(1). PMID: 34620838    Free PMC article.
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Machine Learning for Future Subtyping of the Tumor Microenvironment of Gastro-Esophageal Adenocarcinomas.
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Therapeutic Values of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma: Facts and Hopes.
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Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL.
Gerardo Ferrer, Byeongho Jung, +17 authors, Nicholas Chiorazzi.
Leukemia, 2021 May 04; 35(11). PMID: 33935280    Free PMC article.
A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells.
Thomas Welte, Junhua Mai, +7 authors, Haifa Shen.
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IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies.
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Mol Cancer, 2021 Dec 16; 20(1). PMID: 34906138    Free PMC article.
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer.
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The Cross-Talk between Myeloid and Mesenchymal Stem Cells of Human Bone Marrow Represents a Biomarker of Aging That Regulates Immune Response and Bone Reabsorption.
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Cells, 2022 Jan 12; 11(1). PMID: 35011569    Free PMC article.
A New Trend in Cancer Treatment: The Combination of Epigenetics and Immunotherapy.
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Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy.
Roberto Rangel, Curtis R Pickering, Andrew G Sikora, Michael T Spiotto.
Front Immunol, 2022 Feb 15; 13. PMID: 35154165    Free PMC article.
Review.
The Good, the Bad, and the Ugly: Neutrophils, Angiogenesis, and Cancer.
Irem Ozel, Inga Duerig, +3 authors, Jadwiga Jablonska.
Cancers (Basel), 2022 Feb 16; 14(3). PMID: 35158807    Free PMC article.
Review.
Autoimmune Pemphigus: Latest Advances and Emerging Therapies.
Yen Loo Lim, Gerome Bohelay, +2 authors, Baptiste Janela.
Front Mol Biosci, 2022 Feb 22; 8. PMID: 35187073    Free PMC article.
Review.
Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies.
Weichuan Luo, John V Napoleon, +4 authors, Philip S Low.
Front Immunol, 2022 Mar 08; 13. PMID: 35250995    Free PMC article.
Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV.
Zhong Fang, Yi Zhang, +19 authors, Zhenghong Yuan.
J Exp Med, 2022 Mar 08; 219(4). PMID: 35254403    Free PMC article.
Antigen-Specific TCR-T Cells for Acute Myeloid Leukemia: State of the Art and Challenges.
Synat Kang, Yisheng Li, +4 authors, Li Yu.
Front Oncol, 2022 Apr 01; 12. PMID: 35356211    Free PMC article.
Review.
Polyamines in cancer: integrating organismal metabolism and antitumour immunity.
Cassandra E Holbert, Michael T Cullen, Robert A Casero, Tracy Murray Stewart.
Nat Rev Cancer, 2022 Apr 29;. PMID: 35477776
Review.