Journal Article
. 2010 Feb; 207(3):637-50.
doi: 10.1084/jem.20091918.

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Sergio A Quezada 1 Tyler R Simpson  Karl S Peggs  Taha Merghoub  Jelena Vider  Xiaozhou Fan  Ronald Blasberg  Hideo Yagita  Pawel Muranski  Paul A Antony  Nicholas P Restifo  James P Allison  
Affiliations
  • PMID: 20156971
  •     49 References
  •     391 citations

Abstract

Adoptive transfer of large numbers of tumor-reactive CD8(+) cytotoxic T lymphocytes (CTLs) expanded and differentiated in vitro has shown promising clinical activity against cancer. However, such protocols are complicated by extensive ex vivo manipulations of tumor-reactive cells and have largely focused on CD8(+) CTLs, with much less emphasis on the role and contribution of CD4(+) T cells. Using a mouse model of advanced melanoma, we found that transfer of small numbers of naive tumor-reactive CD4(+) T cells into lymphopenic recipients induces substantial T cell expansion, differentiation, and regression of large established tumors without the need for in vitro manipulation. Surprisingly, CD4(+) T cells developed cytotoxic activity, and tumor rejection was dependent on class II-restricted recognition of tumors by tumor-reactive CD4(+) T cells. Furthermore, blockade of the coinhibitory receptor CTL-associated antigen 4 (CTLA-4) on the transferred CD4(+) T cells resulted in greater expansion of effector T cells, diminished accumulation of tumor-reactive regulatory T cells, and superior antitumor activity capable of inducing regression of spontaneous mouse melanoma. These findings suggest a novel potential therapeutic role for cytotoxic CD4(+) T cells and CTLA-4 blockade in cancer immunotherapy, and demonstrate the potential advantages of differentiating tumor-reactive CD4(+) cells in vivo over current protocols favoring in vitro expansion and differentiation.

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A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Shikhar Mehrotra, Amir A Al-Khami, +15 authors, Michael I Nishimura.
J Immunol, 2012 Jul 17; 189(4). PMID: 22798675    Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer.
Caroline Poli, Caroline Raffin, +3 authors, Danila Valmori.
Haematologica, 2012 Aug 10; 98(2). PMID: 22875619    Free PMC article.
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Ilseyar Akhmetzyanova, Gennadiy Zelinskyy, +4 authors, Ulf Dittmer.
Cancer Immunol Immunother, 2012 Aug 15; 62(2). PMID: 22890822    Free PMC article.
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Carolina M Soto, Jennifer D Stone, +4 authors, David M Kranz.
Cancer Immunol Immunother, 2012 Aug 29; 62(2). PMID: 22926060    Free PMC article.
MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
Therese Liechtenstein, Ines Dufait, +2 authors, David Escors.
Immunol Endocr Metab Agents Med Chem, 2012 Sep 05; 12(3). PMID: 22945252    Free PMC article.
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
Daniel Hirschhorn-Cymerman, Sadna Budhu, +10 authors, Jedd D Wolchok.
J Exp Med, 2012 Sep 26; 209(11). PMID: 23008334    Free PMC article.
Induction of HCA587-specific antitumor immunity with HCA587 protein formulated with CpG and ISCOM in mice.
Juanjuan Chen, Lijie Zhang, +5 authors, Yanhui Yin.
PLoS One, 2012 Oct 17; 7(10). PMID: 23071764    Free PMC article.
Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras.
Hui Wang, Yanping Yang, +4 authors, Yong-Guang Yang.
PLoS One, 2012 Oct 19; 7(10). PMID: 23077554    Free PMC article.
Anti-tumor immunity: myeloid leukocytes control the immune landscape.
Melanie R Rutkowski, Tom L Stephen, Jose R Conejo-Garcia.
Cell Immunol, 2012 Nov 06; 278(1-2). PMID: 23121972    Free PMC article.
Review.
A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response.
Lifeng Wang, Bangxing Hong, +3 authors, Xue F Huang.
PLoS One, 2012 Nov 13; 7(11). PMID: 23145026    Free PMC article.
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
Jing Ni, Matthias Miller, +2 authors, Adelheid Cerwenka.
J Exp Med, 2012 Dec 05; 209(13). PMID: 23209317    Free PMC article.
Highly Cited.
Effector CD4 and CD8 T cells and their role in the tumor microenvironment.
Sine Hadrup, Marco Donia, Per Thor Straten.
Cancer Microenviron, 2012 Dec 18; 6(2). PMID: 23242673    Free PMC article.
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
Marie-Clare St Rose, Roslyn A Taylor, +4 authors, Adam J Adler.
Immunol Cell Biol, 2013 Jan 09; 91(2). PMID: 23295363    Free PMC article.
ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells.
J Ludovic Croxford, Melissa Li Fang Tang, +7 authors, Stephan Gasser.
Blood, 2013 Jan 26; 121(13). PMID: 23349395    Free PMC article.
Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells.
Eric D Mortenson, SaeGwang Park, +2 authors, Yang-Xin Fu.
Clin Cancer Res, 2013 Feb 01; 19(6). PMID: 23363817    Free PMC article.
Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response.
Michel DuPage, Tyler Jacks.
Curr Opin Immunol, 2013 Mar 08; 25(2). PMID: 23465466    Free PMC article.
Review.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
Human MHC Class I-restricted high avidity CD4+ T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.
Shao-An Xue, Liquan Gao, +9 authors, Hans J Stauss.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23483821    Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.
Michael A Curran, Theresa L Geiger, +5 authors, James P Allison.
J Exp Med, 2013 Apr 03; 210(4). PMID: 23547098    Free PMC article.
Highly Cited.
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies.
Konstantinos Liapis, Andrew Clear, +6 authors, John G Gribben.
Blood, 2013 May 09; 122(3). PMID: 23652804    Free PMC article.
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors.
Paul Spear, Amorette Barber, Charles L Sentman.
Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734311    Free PMC article.
Early in vivo signaling profiles in MUC1-specific CD4+ T cells responding to two different MUC1-targeting vaccines in two different microenvironments.
Dawn K Reichenbach, Olivera J Finn.
Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802084    Free PMC article.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.
Michael Kalos, Carl H June.
Immunity, 2013 Jul 31; 39(1). PMID: 23890063    Free PMC article.
Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Low immunogenicity of neural progenitor cells differentiated from induced pluripotent stem cells derived from less immunogenic somatic cells.
Pengfei Liu, Shubin Chen, +10 authors, Duanqing Pei.
PLoS One, 2013 Aug 08; 8(7). PMID: 23922758    Free PMC article.
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.
Jennifer D Stone, David M Kranz.
Front Immunol, 2013 Aug 24; 4. PMID: 23970885    Free PMC article.
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection.
Laiqing Hua, Shuyu Yao, +7 authors, Jie Sun.
J Virol, 2013 Aug 30; 87(21). PMID: 23986597    Free PMC article.
Changing T-cell enigma: cancer killing or cancer control?
Thomas Wieder, Heidi Braumüller, +2 authors, Martin Röcken.
Cell Cycle, 2013 Sep 10; 12(19). PMID: 24013429    Free PMC article.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy.
Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría.
Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.
Sarah E Church, Shawn M Jensen, +2 authors, Bernard A Fox.
Eur J Immunol, 2013 Oct 12; 44(1). PMID: 24114780    Free PMC article.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.
Paula D Bos, George Plitas, +2 authors, Alexander Y Rudensky.
J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486    Free PMC article.
Highly Cited.
Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth.
Matthias Hardtke-Wolenski, Lilli Kraus, +7 authors, Thorsten Lieke.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205259    Free PMC article.
Human cell-based artificial antigen-presenting cells for cancer immunotherapy.
Marcus O Butler, Naoto Hirano.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329798    Free PMC article.
Review.
Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers.
Arnab Ghosh, Amanda M Holland, Marcel R M van den Brink.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329800    Free PMC article.
Review.
Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapy.
Michal Kuczma, Agnieszka Kurczewska, Piotr Kraj.
J Immunotoxicol, 2013 Dec 20; 11(4). PMID: 24350726    Free PMC article.
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
Liufu Deng, Hua Liang, +4 authors, Yang-Xin Fu.
J Clin Invest, 2014 Jan 03; 124(2). PMID: 24382348    Free PMC article.
Highly Cited.
Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.
Junji Yatsuda, Atsushi Irie, +14 authors, Yasuharu Nishimura.
PLoS One, 2014 Jan 05; 8(12). PMID: 24386437    Free PMC article.
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients.
Shigehisa Kitano, Takemasa Tsuji, +7 authors, Jedd D Wolchok.
Cancer Immunol Res, 2014 Jan 08; 1(4). PMID: 24396833    Free PMC article.
TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.
Mohammad N Uddin, Yubin Zhang, +2 authors, Dorina Avram.
J Immunol, 2014 Jan 22; 192(4). PMID: 24446520    Free PMC article.
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
Zulkarnain Harfuddin, Shaqireen Kwajah, +2 authors, Herbert Schwarz.
Oncoimmunology, 2014 Feb 01; 2(11). PMID: 24482752    Free PMC article.
Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.
Bryan D Choi, Patrick C Gedeon, +6 authors, John H Sampson.
Cancer Immunol Res, 2014 Feb 27; 1(3). PMID: 24570975    Free PMC article.
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.
Thinle Chodon, Begoña Comin-Anduix, +31 authors, Antoni Ribas.
Clin Cancer Res, 2014 Mar 19; 20(9). PMID: 24634374    Free PMC article.
Highly Cited.
Immunization with a peptide containing MHC class I and II epitopes derived from the tumor antigen SIM2 induces an effective CD4 and CD8 T-cell response.
Haydn T Kissick, Martin G Sanda, Laura K Dunn, Mohamed S Arredouani.
PLoS One, 2014 Apr 03; 9(4). PMID: 24690990    Free PMC article.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Emily B Heikamp, Chirag H Patel, +10 authors, Jonathan D Powell.
Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705297    Free PMC article.
Highly Cited.
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Ole Audun Werner Haabeth, Anders Aune Tveita, +8 authors, Bjarne Bogen.
Front Immunol, 2014 May 02; 5. PMID: 24782871    Free PMC article.
Highly Cited. Review.
Implementing combinatorial immunotherapeutic regimens against cancer: The concept of immunological conditioning.
Dominik Wolf, Annkristin Heine, Peter Brossart.
Oncoimmunology, 2014 May 07; 3(1). PMID: 24800168    Free PMC article.
Review.
Variability in CRP, regulatory T cells and effector T cells over time in gynaecological cancer patients: a study of potential oscillatory behaviour and correlations.
Mutsa T Madondo, Sandra Tuyaerts, +6 authors, Magdalena Plebanski.
J Transl Med, 2014 Jun 25; 12. PMID: 24957270    Free PMC article.
HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.
Jacob Couturier, Alexander T Hutchison, +11 authors, Dorothy E Lewis.
Virology, 2014 Jul 08; 462-463. PMID: 24999042    Free PMC article.
A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy.
Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong.
J Immunol Res, 2014 Jul 11; 2014. PMID: 25009822    Free PMC article.
Review.
A vaccine targeting mutant IDH1 induces antitumour immunity.
Theresa Schumacher, Lukas Bunse, +24 authors, Michael Platten.
Nature, 2014 Jul 22; 512(7514). PMID: 25043048
Highly Cited.
Dasatinib promotes Th1-type responses in granzyme B expressing T-cells.
Anna Kreutzman, Mette Ilander, +2 authors, Satu Mustjoki.
Oncoimmunology, 2014 Aug 02; 3. PMID: 25083322    Free PMC article.
TGFβ in T cell biology and tumor immunity: Angel or devil?
Eric Tu, Pei Zhi Cheryl Chia, Wanjun Chen.
Cytokine Growth Factor Rev, 2014 Aug 27; 25(4). PMID: 25156420    Free PMC article.
Review.
Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells.
Lin Lin, Jacob Couturier, +3 authors, Dorothy E Lewis.
BMC Immunol, 2014 Sep 24; 15. PMID: 25245659    Free PMC article.
CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic.
Michael L Freeman, Claire E Burkum, +11 authors, Marcia A Blackman.
J Immunol, 2014 Nov 08; 193(12). PMID: 25378595    Free PMC article.
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.
Carsten Linnemann, Marit M van Buuren, +13 authors, Ton N M Schumacher.
Nat Med, 2014 Dec 23; 21(1). PMID: 25531942
Highly Cited.
Proximity ligation assay evaluates IDH1R132H presentation in gliomas.
Lukas Bunse, Theresa Schumacher, +13 authors, Michael Platten.
J Clin Invest, 2015 Jan 03; 125(2). PMID: 25555220    Free PMC article.
Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.
Xiaoyun Lu, Zhi-Chun Ding, +8 authors, Gang Zhou.
J Immunol, 2015 Jan 07; 194(4). PMID: 25560408    Free PMC article.
Metastatic melanoma cells evade immune detection by silencing STAT1.
JoDi Lynn Osborn, Susanna F Greer.
Int J Mol Sci, 2015 Feb 19; 16(2). PMID: 25690042    Free PMC article.
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma.
Yong Zheng, Greg Parsonage, +7 authors, Steven P Lee.
Cancer Immunol Res, 2015 Feb 26; 3(10). PMID: 25711537    Free PMC article.
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan.
Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538    Free PMC article.
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.
Edward J Wyluda, Jihua Cheng, +8 authors, Joseph J Drabick.
Cancer Biol Ther, 2015 Mar 26; 16(5). PMID: 25806780    Free PMC article.
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma.
Serena Pellegatta, Lorella Valletta, +8 authors, Gaetano Finocchiaro.
Acta Neuropathol Commun, 2015 Apr 08; 3. PMID: 25849072    Free PMC article.
An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen.
Matthew P Rausch, Karen Taraszka Hastings.
PLoS One, 2015 Apr 16; 10(4). PMID: 25875653    Free PMC article.
Limitations of bystander killing in Th1/M1 immune responses against a secreted tumor antigen.
Anders Aune Tveita, Ole Audun Haabeth, Bjarne Bogen.
Oncoimmunology, 2015 May 06; 3(9). PMID: 25941607    Free PMC article.
An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.
Neeraj Lal, Andrew D Beggs, Benjamin E Willcox, Gary W Middleton.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949894    Free PMC article.
Autologous cellular vaccine overcomes cancer immunoediting in a mouse model of myeloma.
Marta Mazzocco, Matteo Martini, +12 authors, Silvia Sartoris.
Immunology, 2015 May 12; 146(1). PMID: 25959091    Free PMC article.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity.
Yunfei Zhang, Yong Zhang, +2 authors, Wen Luo.
PLoS One, 2015 May 12; 10(5). PMID: 25961716    Free PMC article.
Mutant IDH1: An immunotherapeutic target in tumors.
Theresa Schumacher, Lukas Bunse, Wolfgang Wick, Michael Platten.
Oncoimmunology, 2015 May 13; 3(12). PMID: 25964867    Free PMC article.
The role of the tumor microenvironment in HIV-associated lymphomas.
Joseph G Taylor, Konstantinos Liapis, John G Gribben.
Biomark Med, 2015 May 20; 9(5). PMID: 25985176    Free PMC article.
Review.
Cancer immunotherapy: exploiting neoepitopes.
Michael Platten, Rienk Offringa.
Cell Res, 2015 Jun 03; 25(8). PMID: 26032267    Free PMC article.
EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.
Laura Pisapia, Pasquale Barba, +3 authors, Giovanna Del Pozzo.
Int J Oncol, 2015 Jun 18; 47(2). PMID: 26081906    Free PMC article.
Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.
Maud Condomines, Jon Arnason, +3 authors, Michel Sadelain.
PLoS One, 2015 Jun 26; 10(6). PMID: 26110267    Free PMC article.
Rapid generation of NY-ESO-1-specific CD4+ THELPER1 cells for adoptive T-cell therapy.
Simone Kayser, Cristina Boβ, +11 authors, Tobias Feuchtinger.
Oncoimmunology, 2015 Jul 15; 4(5). PMID: 26155389    Free PMC article.
Clinical Development of Immune Checkpoint Inhibitors.
Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano.
Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407    Free PMC article.
Review.
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity.
Daniela Weiskopf, Derek J Bangs, +6 authors, Alessandro Sette.
Proc Natl Acad Sci U S A, 2015 Jul 22; 112(31). PMID: 26195744    Free PMC article.
Highly Cited.
Therapeutic cancer vaccines.
Cornelis J M Melief, Thorbald van Hall, +2 authors, Sjoerd H van der Burg.
J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521    Free PMC article.
Highly Cited. Review.
Identification of novel Lck-derived T helper epitope long peptides applicable for HLA-A2(+) cancer patients as cancer vaccine.
Satoko Matsueda, Shigeki Shichijo, +4 authors, Kyogo Itoh.
Cancer Sci, 2015 Sep 04; 106(11). PMID: 26331453    Free PMC article.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine.
Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591    Free PMC article.
Review.
CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.
G Elizabeth Pluhar, Christopher A Pennell, Michael R Olin.
Crit Rev Immunol, 2015 Sep 10; 35(2). PMID: 26351148    Free PMC article.
Review.
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Mamoru Kawahara, Hiroshi Takaku.
Cancer Biol Ther, 2015 Sep 24; 16(11). PMID: 26391871    Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Junko Matsuzaki, Takemasa Tsuji, +7 authors, Kunle Odunsi.
Sci Rep, 2015 Oct 09; 5. PMID: 26447332    Free PMC article.
IL-1βR-dependent priming of antitumor CD4+ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria.
Sabine Kuhn, Jianping Yang, +3 authors, Franca Ronchese.
Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451307    Free PMC article.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Review.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.
Payal Mittal, Marie-Clare St Rose, +4 authors, Adam J Adler.
J Immunol, 2015 Nov 13; 195(12). PMID: 26561553    Free PMC article.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.
Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong.
J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545    Free PMC article.
Review.
Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut.
Yunji Park, Sook-Jin Moon, Seung-Woo Lee.
BMB Rep, 2015 Nov 26; 49(1). PMID: 26592937    Free PMC article.
Review.
Melanoma: oncogenic drivers and the immune system.
Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell.
Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311    Free PMC article.
Review.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
Arata Takeuchi, Mohamed El Sherif Gadelhaq Badr, +11 authors, Takashi Saito.
J Exp Med, 2015 Dec 24; 213(1). PMID: 26694968    Free PMC article.
Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells.
Maurizio Perdicchio, Lenneke A M Cornelissen, +6 authors, Wendy W J Unger.
Oncotarget, 2016 Jan 08; 7(8). PMID: 26741508    Free PMC article.
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.
Nicole Malandro, Sadna Budhu, +9 authors, Jedd D Wolchok.
Immunity, 2016 Jan 21; 44(1). PMID: 26789923    Free PMC article.
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic.
Kinga Majchrzak, Michelle H Nelson, +5 authors, Chrystal M Paulos.
Cancer Immunol Immunother, 2016 Jan 31; 65(3). PMID: 26825102    Free PMC article.
Review.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen.
Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth.
Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.
Jennifer Nguyen, Richard Bernert, +4 authors, K Taraszka Hastings.
Melanoma Res, 2016 Mar 02; 26(2). PMID: 26930048    Free PMC article.
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Meng-Lei Zhu, Pearl Bakhru, +6 authors, Maureen A Su.
Nat Commun, 2016 Apr 14; 7. PMID: 27072778    Free PMC article.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity.
Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth.
Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060    Free PMC article.
Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma.
Hongwei Xue, Fuhuang Lin, +3 authors, Ludong Zhao.
PLoS One, 2016 May 03; 11(5). PMID: 27136203    Free PMC article.
Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy.
Xin Yao, Yong-Chen Lu, +8 authors, Paul F Robbins.
J Immunother, 2016 May 11; 39(5). PMID: 27163739    Free PMC article.
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.
Hidetoshi Nakagawa, Jessica M Sido, +3 authors, Hye-Jung Kim.
Proc Natl Acad Sci U S A, 2016 May 18; 113(22). PMID: 27185917    Free PMC article.
Origins of the cytolytic synapse.
Maike de la Roche, Yukako Asano, Gillian M Griffiths.
Nat Rev Immunol, 2016 Jun 07; 16(7). PMID: 27265595
Review.
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.
Soraya Zorro Manrique, Ana L Dominguez, +7 authors, Peter A Cohen.
Oncotarget, 2016 Jun 25; 7(28). PMID: 27341020    Free PMC article.
Modeling Human Leukemia Immunotherapy in Humanized Mice.
Jinxing Xia, Zheng Hu, +7 authors, Yong-Guang Yang.
EBioMedicine, 2016 Jul 11; 10. PMID: 27394641    Free PMC article.
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model.
H W Li, P Vishwasrao, +4 authors, M Sykes.
Am J Transplant, 2016 Jul 13; 17(2). PMID: 27401926    Free PMC article.
Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting.
Mikko Siurala, Markus Vähä-Koskela, +6 authors, Akseli Hemminki.
Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467954    Free PMC article.
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.
Masatoshi Hirayama, Yusuke Tomita, +16 authors, Yasuharu Nishimura.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471607    Free PMC article.
The immune network in thyroid cancer.
Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471646    Free PMC article.
Review.
IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.
Zhi-Chun Ding, Chufeng Liu, +10 authors, Gang Zhou.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471650    Free PMC article.
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Kunyu Li, Margaret Baird, +3 authors, Sarah Young.
Clin Transl Immunology, 2016 Sep 03; 5(8). PMID: 27588200    Free PMC article.
Potential use of lymph node-derived HPV-specific T cells for adoptive cell therapy of cervical cancer.
Mariëtte I E van Poelgeest, Valeria V Visconti, +10 authors, Marij J P Welters.
Cancer Immunol Immunother, 2016 Sep 14; 65(12). PMID: 27619514    Free PMC article.
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display.
Anders Tveita, Marte Fauskanger, Bjarne Bogen, Ole Audun Werner Haabeth.
Oncotarget, 2016 Sep 15; 7(41). PMID: 27626487    Free PMC article.
Effect of systemic injection of heterogenous and homogenous opioids on peripheral cellular immune response in rats with bone cancer pain: A comparative study.
Jun-Ying Du, Yi Liang, +4 authors, Jian-Qiao Fang.
Exp Ther Med, 2016 Oct 06; 12(4). PMID: 27703511    Free PMC article.
CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade.
Hongxia Yan, Xianglian Hou, +4 authors, Ruijie Zhu.
Tumour Biol, 2016 Oct 07;. PMID: 27709550
Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients.
Maggie L Diller, Ragini R Kudchadkar, +2 authors, Mandy L Ford.
J Immunother, 2016 Oct 16; 39(9). PMID: 27741090    Free PMC article.
Intratumoral accumulation of podoplanin-expressing lymph node stromal cells promote tumor growth through elimination of CD4+ tumor-infiltrating lymphocytes.
Aikaterini Hatzioannou, Saba Nayar, +3 authors, Panayotis Verginis.
Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757315    Free PMC article.
Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8+ and CD4+ T-cell responses with multiple specificities including a novel DR7-restricted epitope.
P Baumgaertner, C Costa Nunes, +15 authors, C Jandus.
Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853637    Free PMC article.
Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells.
Michal Kuczma, Zhi-Chun Ding, Gang Zhou.
Crit Rev Immunol, 2016 Dec 03; 36(2). PMID: 27910767    Free PMC article.
Review.
Peptide vaccines in cancer-old concept revisited.
Takumi Kumai, Hiroya Kobayashi, Yasuaki Harabuchi, Esteban Celis.
Curr Opin Immunol, 2016 Dec 13; 45. PMID: 27940327    Free PMC article.
Review.
Targeting B-cell malignancies through human B-cell receptor specific CD4+ T cells.
Jinsheng Weng, Flavio Egidio Baio, +10 authors, Larry W Kwak.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999743    Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.
Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella.
Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531    Free PMC article.
Review.
Engaging Natural Killer T Cells as 'Universal Helpers' for Vaccination.
Mary Speir, Ian F Hermans, Robert Weinkove.
Drugs, 2016 Dec 23; 77(1). PMID: 28005229
Review.
Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication.
Ainhoa Arina, Theodore Karrison, +3 authors, Hans Schreiber.
Cancer Immunol Res, 2017 Jan 13; 5(2). PMID: 28077434    Free PMC article.
The distribution and function of human memory T cell subsets in lung cancer.
Si Yuan Sheng, Yong Gu, +3 authors, RongFu Wang.
Immunol Res, 2017 Jan 20; 65(3). PMID: 28101811    Free PMC article.
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function.
Arata Takeuchi, Takashi Saito.
Front Immunol, 2017 Mar 11; 8. PMID: 28280496    Free PMC article.
Highly Cited. Review.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.
Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein.
Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853    Free PMC article.
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Michael S Khodadoust, Niclas Olsson, +23 authors, Ash A Alizadeh.
Nature, 2017 Mar 23; 543(7647). PMID: 28329770    Free PMC article.
Highly Cited.
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response.
Kun He, Ping Liu, Lisa X Xu.
Cell Death Dis, 2017 Mar 24; 8(3). PMID: 28333145    Free PMC article.
Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy.
Riikka Havunen, Mikko Siurala, +10 authors, Akseli Hemminki.
Mol Ther Oncolytics, 2017 Mar 28; 4. PMID: 28345026    Free PMC article.
IDO and galectin-3 hamper the ex vivo generation of clinical grade tumor-specific T cells for adoptive cell therapy in metastatic melanoma.
Sara M Melief, Marten Visser, Sjoerd H van der Burg, Els M E Verdegaal.
Cancer Immunol Immunother, 2017 Apr 13; 66(7). PMID: 28401257    Free PMC article.
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity.
Kinga Majchrzak, Michelle H Nelson, +9 authors, Chrystal M Paulos.
JCI Insight, 2017 Apr 20; 2(8). PMID: 28422756    Free PMC article.
Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma.
Jacek J Sznurkowski, Anton Żawrocki, Wojciech Biernat.
Oncotarget, 2017 May 19; 8(28). PMID: 28515351    Free PMC article.
Bispecific antibody does not induce T-cell death mediated by chimeric antigen receptor against disialoganglioside GD2.
Sayed Shahabuddin Hoseini, Konstantin Dobrenkov, +2 authors, Nai-Kong V Cheung.
Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680755    Free PMC article.
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.
Rigel J Kishton, Madhusudhanan Sukumar, Nicholas P Restifo.
Cell Metab, 2017 Jul 07; 26(1). PMID: 28683298    Free PMC article.
Highly Cited. Review.
Vaccines targeting helper T cells for cancer immunotherapy.
Marit Melssen, Craig L Slingluff.
Curr Opin Immunol, 2017 Jul 30; 47. PMID: 28755541    Free PMC article.
Review.
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.
Yong-Chen Lu, Linda L Parker, +14 authors, Steven A Rosenberg.
J Clin Oncol, 2017 Aug 16; 35(29). PMID: 28809608    Free PMC article.
Highly Cited.
Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling.
In Ah Park, Seong-Hye Hwang, +7 authors, Hee Jin Lee.
PLoS One, 2017 Aug 18; 12(8). PMID: 28817603    Free PMC article.
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade.
Howard Y Li, Maria McSharry, +8 authors, Raphael A Nemenoff.
Cancer Immunol Res, 2017 Aug 19; 5(9). PMID: 28819064    Free PMC article.
Characterization of Demodex musculi Infestation, Associated Comorbidities, and Topographic Distribution in a Mouse Strain with Defective Adaptive Immunity.
Melissa A Nashat, Kerith R Luchins, +3 authors, Neil S Lipman.
Comp Med, 2017 Aug 24; 67(4). PMID: 28830578    Free PMC article.
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics.
Z Wu, N V Cheung.
Pharmacol Ther, 2017 Aug 24; 182. PMID: 28834699    Free PMC article.
Review.
CIMT 2017: Anniversary symposium - Report on the 15th CIMT Annual Meeting of the Association for Cancer Immunotherapy.
Lena M Kranz, Jan D Beck, +3 authors, Mustafa Diken.
Hum Vaccin Immunother, 2017 Aug 29; 13(10). PMID: 28846471    Free PMC article.
Most Do, but Some Do Not: CD4⁺CD25- T Cells, but Not CD4⁺CD25⁺ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR).
Andreas A Hombach, Hinrich Abken.
Cancers (Basel), 2017 Aug 30; 9(9). PMID: 28850063    Free PMC article.
Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells.
Tomohiro Tanaka, Satoshi Watanabe, +20 authors, Toshiaki Kikuchi.
PLoS One, 2017 Aug 31; 12(8). PMID: 28854279    Free PMC article.
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.
David J Messenheimer, Shawn M Jensen, +6 authors, Bernard A Fox.
Clin Cancer Res, 2017 Sep 01; 23(20). PMID: 28855348    Free PMC article.
Highly Cited.
Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
Pearl Bakhru, Meng-Lei Zhu, +14 authors, Maureen A Su.
JCI Insight, 2017 Sep 22; 2(18). PMID: 28931755    Free PMC article.
Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells.
Zhi-Chun Ding, Tsadik Habtetsion, +8 authors, Gang Zhou.
Sci Rep, 2017 Sep 25; 7(1). PMID: 28939858    Free PMC article.
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.
Andrea J Manrique-Rincón, Camila M Beraldo, Jessica M Toscaro, Marcio C Bajgelman.
Front Immunol, 2017 Oct 05; 8. PMID: 28974950    Free PMC article.
Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression.
Liesbet M Peeters, Marjan Vanheusden, +4 authors, Niels Hellings.
Front Immunol, 2017 Oct 06; 8. PMID: 28979263    Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Review.
KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer.
Neeraj Lal, Brian S White, +7 authors, Gary W Middleton.
Clin Cancer Res, 2017 Oct 25; 24(1). PMID: 29061646    Free PMC article.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions.
Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu.
Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133    Free PMC article.
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Cameron S Field, Martin K Hunn, +3 authors, Ian F Hermans.
Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296535    Free PMC article.
An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.
Payal Mittal, Rebecca Abblett, +8 authors, Adam J Adler.
J Immunol, 2018 Jan 07; 200(4). PMID: 29305435    Free PMC article.
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses.
Il-Kyu Choi, Zhe Wang, +10 authors, Baochun Zhang.
Proc Natl Acad Sci U S A, 2018 Jan 10; 115(4). PMID: 29311309    Free PMC article.
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.
Charlotte E Ariyan, Mary Sue Brady, +19 authors, James P Allison.
Cancer Immunol Res, 2018 Jan 18; 6(2). PMID: 29339377    Free PMC article.
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma.
Joshua R Veatch, Sylvia M Lee, +10 authors, Stanley R Riddell.
J Clin Invest, 2018 Jan 24; 128(4). PMID: 29360643    Free PMC article.
Highly Cited.
Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.
Dmitri I Kotov, Jessica A Kotov, Michael F Goldberg, Marc K Jenkins.
J Immunol, 2018 Feb 14; 200(6). PMID: 29436413    Free PMC article.
The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes.
Yasmina Serroukh, Chunyan Gu-Trantien, +15 authors, Arnaud Marchant.
Elife, 2018 Mar 01; 7. PMID: 29488879    Free PMC article.
Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma.
Kendra C Foley, Michael I Nishimura, Tamson V Moore.
Melanoma Res, 2018 Mar 10; 28(3). PMID: 29521881    Free PMC article.
Review.
Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling.
Masafumi Taniwaki, Mihoko Yoshida, +3 authors, Hiroto Kaneko.
Mediterr J Hematol Infect Dis, 2018 Mar 14; 10(1). PMID: 29531651    Free PMC article.
Review.
Comparison of Diagnostic Methods and Sampling Sites for the Detection of Demodex musculi.
Melissa A Nashat, Rodolfo J Ricart Arbona, +4 authors, Neil S Lipman.
J Am Assoc Lab Anim Sci, 2018 Mar 21; 57(2). PMID: 29555007    Free PMC article.
Foxo transcription factors in T cell biology and tumor immunity.
Chong T Luo, Ming O Li.
Semin Cancer Biol, 2018 Apr 24; 50. PMID: 29684436    Free PMC article.
Review.
Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo.
Francesca Romana Stefani, Sofia Eberstål, +2 authors, Johan Bengzon.
Int J Cancer, 2018 May 13; 143(9). PMID: 29752716    Free PMC article.
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity.
Dongrui Wang, Brenda Aguilar, +6 authors, Christine E Brown.
JCI Insight, 2018 May 18; 3(10). PMID: 29769444    Free PMC article.
Highly Cited.
Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.
T N Sharapova, E A Romanova, L P Sashchenko, D V Yashin.
J Immunol Res, 2018 Jun 01; 2018. PMID: 29850628    Free PMC article.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial.
Poulam M Patel, Christian H Ottensmeier, +15 authors, Lindy G Durrant.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872563    Free PMC article.
Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma.
Felipe Gálvez-Cancino, Ernesto López, +11 authors, Alvaro Lladser.
Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900048    Free PMC article.
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.
Themis Alissafi, Aikaterini Hatzioannou, +8 authors, Panayotis Verginis.
J Clin Invest, 2018 Jun 20; 128(9). PMID: 29920188    Free PMC article.
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies.
Vanessa M Tubb, Deborah S Schrikkema, +7 authors, Gavin M Bendle.
J Immunother Cancer, 2018 Jul 14; 6(1). PMID: 30001747    Free PMC article.
Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy.
João Manuel Santos, Víctor Cervera-Carrascon, +6 authors, Akseli Hemminki.
Mol Ther, 2018 Jul 19; 26(9). PMID: 30017877    Free PMC article.
Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity.
Marte Fauskanger, Ole Audun Werner Haabeth, +2 authors, Anders Aune Tveita.
Front Immunol, 2018 Aug 08; 9. PMID: 30083157    Free PMC article.
The Paradoxical Role of NKG2D in Cancer Immunity.
Sam Sheppard, Amir Ferry, Joana Guedes, Nadia Guerra.
Front Immunol, 2018 Aug 29; 9. PMID: 30150983    Free PMC article.
Review.
Synaptic Interactions in Germinal Centers.
Ilenia Papa, Carola G Vinuesa.
Front Immunol, 2018 Aug 29; 9. PMID: 30150988    Free PMC article.
Review.
Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.
Soyoko Morimoto, Fumihiro Fujiki, +12 authors, Haruo Sugiyama.
Oncotarget, 2018 Oct 23; 9(75). PMID: 30344927    Free PMC article.
Antigen-armed antibodies against B-cell malignancies.
Marta Ilecka, Dwain G van Zyl, Henri-Jacques Delecluse.
Oncotarget, 2018 Nov 28; 9(86). PMID: 30479687    Free PMC article.
Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.
Anna E Oja, Berber Piet, +8 authors, Pleun Hombrink.
Front Immunol, 2018 Dec 07; 9. PMID: 30505306    Free PMC article.
Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.
Yan Xia, Xiaopeng Tian, +10 authors, Mingjun Wang.
Oncol Lett, 2018 Dec 14; 16(6). PMID: 30546433    Free PMC article.
A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity.
Diana Rasoulouniriana, Nadine Santana-Magal, +11 authors, Yaron Carmi.
J Clin Invest, 2019 Aug 27; 129(10). PMID: 31449054    Free PMC article.
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
Yochai Wolf, Osnat Bartok, +26 authors, Yardena Samuels.
Cell, 2019 Sep 17; 179(1). PMID: 31522890    Free PMC article.
Highly Cited.
T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity.
Preeti Sharma, Daniel T Harris, Jennifer D Stone, David M Kranz.
Cancer Immunol Res, 2019 Sep 25; 7(12). PMID: 31548259    Free PMC article.
High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma.
Kenneth H Buetow, Lydia R Meador, +6 authors, K Taraszka Hastings.
J Immunol, 2019 Oct 09; 203(10). PMID: 31591149    Free PMC article.
Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies.
Spencer C Wei, Nana-Ama A S Anang, +8 authors, James P Allison.
Proc Natl Acad Sci U S A, 2019 Oct 23; 116(45). PMID: 31636208    Free PMC article.
Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile.
Rosa De Groot, Marleen M Van Loenen, +13 authors, Monika C Wolkers.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646094    Free PMC article.
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
Kosuke Hashimoto, Tsukasa Kouno, +17 authors, Piero Carninci.
Proc Natl Acad Sci U S A, 2019 Nov 14; 116(48). PMID: 31719197    Free PMC article.
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.
Lotte K Kristensen, Camilla Fröhlich, +8 authors, Andreas Kjaer.
Theranostics, 2019 Nov 23; 9(26). PMID: 31754392    Free PMC article.
The Ancient Chinese Decoction Yu-Ping-Feng Suppresses Orthotopic Lewis Lung Cancer Tumor Growth Through Increasing M1 Macrophage Polarization and CD4+ T Cell Cytotoxicity.
Lixin Wang, Wenbin Wu, +7 authors, Shiguo Zhu.
Front Pharmacol, 2019 Nov 30; 10. PMID: 31780946    Free PMC article.
A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2.
Ryota Tamura, Masato Fujioka, +14 authors, Masahiro Toda.
Nat Commun, 2019 Dec 19; 10(1). PMID: 31848332    Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.
Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada.
Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228    Free PMC article.
Review.
Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model.
T C Felizardo, J C M Wang, +5 authors, J A Medin.
Gene Ther, 2011 Apr 15; 18(10). PMID: 21490686    Free PMC article.
Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.
Mikhail Binnewies, Adriana M Mujal, +15 authors, Matthew F Krummel.
Cell, 2019 Apr 09; 177(3). PMID: 30955881    Free PMC article.
Highly Cited.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige Yoshida, Masanori Okamoto, +13 authors, Naoto Saito.
BMC Cancer, 2020 Jan 10; 20(1). PMID: 31914969    Free PMC article.
MicroRNA delivery through nanoparticles.
Sharon Wei Ling Lee, Camilla Paoletti, +5 authors, Valeria Chiono.
J Control Release, 2019 Oct 18; 313. PMID: 31622695    Free PMC article.
Review.
Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth.
Jiping Wang, Jianmei W Leavenworth, +5 authors, Peter H King.
Glia, 2019 Aug 11; 67(12). PMID: 31400163    Free PMC article.
Fibrogenesis in Chronic DSS Colitis is Not Influenced by Neutralisation of Regulatory T Cells, of Major T Helper Cytokines or Absence of IL-13.
Brecht Creyns, Jonathan Cremer, +7 authors, Christine Breynaert.
Sci Rep, 2019 Jul 13; 9(1). PMID: 31296924    Free PMC article.
Therapeutic cancer vaccine: building the future from lessons of the past.
T Tran, C Blanc, +3 authors, Eric Tartour.
Semin Immunopathol, 2018 Jul 07; 41(1). PMID: 29978248
Review.
Biological Consequences of MHC-II Expression by Tumor Cells in Cancer.
Margaret L Axelrod, Rebecca S Cook, Douglas B Johnson, Justin M Balko.
Clin Cancer Res, 2018 Nov 23; 25(8). PMID: 30463850    Free PMC article.
Review.
Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Lucia Poncette, Xiaojing Chen, Felix Km Lorenz, Thomas Blankenstein.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530988    Free PMC article.
High-affinity T cell receptors for adoptive cell transfer.
Ariel Isser, Jonathan P Schneck.
J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530992    Free PMC article.
A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab.
Theodore S Nowicki, Beata Berent-Maoz, +18 authors, Antoni Ribas.
Clin Cancer Res, 2018 Dec 24; 25(7). PMID: 30573690    Free PMC article.
Therapeutic Cancer Vaccines-T Cell Responses and Epigenetic Modulation.
Apriliana E R Kartikasari, Monica D Prakash, +4 authors, Magdalena Plebanski.
Front Immunol, 2019 Feb 12; 9. PMID: 30740111    Free PMC article.
Review.
Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.
Vid Leko, Lucas A McDuffie, +6 authors, Yong-Chen Lu.
J Immunol, 2019 May 01; 202(12). PMID: 31036766    Free PMC article.
Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism.
Crystal Morales Del Valle, Joseph R Maxwell, +5 authors, Anthony T Vella.
Cell Rep, 2019 May 03; 27(5). PMID: 31042471    Free PMC article.
Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.
Nithya Sivaram, Patrick A McLaughlin, +7 authors, Richard Z Lin.
J Clin Invest, 2019 May 22; 129(8). PMID: 31112530    Free PMC article.
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.
Yehezqel Elyahu, Idan Hekselman, +12 authors, Alon Monsonego.
Sci Adv, 2019 Aug 29; 5(8). PMID: 31457092    Free PMC article.
Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53.
Justine Habault, Anna Kaci, +6 authors, Jean-Luc Poyet.
Oncoimmunology, 2020 Mar 12; 9(1). PMID: 32158621    Free PMC article.
Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy.
Maureen A Su, Mark S Anderson.
Cancer Immunol Res, 2019 Jun 05; 7(6). PMID: 31160305    Free PMC article.
Review.
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation.
Teresa Preglej, Patricia Hamminger, +22 authors, Wilfried Ellmeier.
JCI Insight, 2020 Feb 28; 5(4). PMID: 32102981    Free PMC article.
Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity.
Rajkumar Noubade, Sonia Majri-Morrison, Kristin V Tarbell.
Front Immunol, 2019 May 31; 10. PMID: 31143179    Free PMC article.
Review.
HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy.
Alexandre Couture, Anthony Garnier, +5 authors, Olivier Toutirais.
Front Immunol, 2019 Jun 04; 10. PMID: 31156634    Free PMC article.
Review.
Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype.
David Eisel, Krishna Das, +3 authors, Stefan B Eichmüller.
Front Immunol, 2019 Mar 12; 10. PMID: 30853959    Free PMC article.
Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model.
Daniela Elgueta, Francisco Contreras, +9 authors, Rodrigo Pacheco.
Front Immunol, 2019 May 24; 10. PMID: 31118938    Free PMC article.
Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells.
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Front Immunol, 2019 Aug 06; 10. PMID: 31379821    Free PMC article.
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Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer.
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J Immunother Cancer, 2019 Aug 01; 7(1). PMID: 31362778    Free PMC article.
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Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives.
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Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications.
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Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486257    Free PMC article.
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CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages.
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Blood Adv, 2020 Jun 17; 4(12). PMID: 32544236    Free PMC article.
CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells.
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J Immunother Cancer, 2020 Jun 26; 8(1). PMID: 32581054    Free PMC article.
GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen.
Matthew P Rausch, Lydia R Meador, +4 authors, K Taraszka Hastings.
J Immunol, 2020 Apr 10; 204(11). PMID: 32269095    Free PMC article.
Annona muricata L.-Derived Polysaccharides as a Potential Adjuvant to a Dendritic Cell-Based Vaccine in a Thymoma-Bearing Model.
Woo Sik Kim, Jeong Moo Han, +3 authors, Eui-Baek Byun.
Nutrients, 2020 Jun 04; 12(6). PMID: 32486094    Free PMC article.
Telomerase and CD4 T Cell Immunity in Cancer.
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Cancers (Basel), 2020 Jul 08; 12(6). PMID: 32630460    Free PMC article.
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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
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Immunity, 2020 Jan 12; 52(1). PMID: 31924474    Free PMC article.
Immunity to X-linked inhibitor of apoptosis protein (XIAP) in malignant melanoma and check-point blockade.
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Cancer Immunol Immunother, 2019 Jul 19; 68(8). PMID: 31317218    Free PMC article.
Engineering CD4+ T Cells to Enhance Cancer Immunity.
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Cells, 2020 Jul 28; 9(7). PMID: 32708397    Free PMC article.
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CD8+ T cell states in human cancer: insights from single-cell analysis.
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Nat Rev Cancer, 2020 Feb 07; 20(4). PMID: 32024970    Free PMC article.
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Endocrinopathies Associated with Immune Checkpoint Inhibitor Cancer Treatment: A Review.
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J Clin Med, 2020 Jul 03; 9(7). PMID: 32610470    Free PMC article.
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Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
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Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
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The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.
Joji Nagasaki, Yosuke Togashi, +10 authors, Hiroyoshi Nishikawa.
Blood Adv, 2020 Sep 02; 4(17). PMID: 32870971    Free PMC article.
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice.
Nadja Salomon, Fulvia Vascotto, +9 authors, Sebastian Kreiter.
Oncoimmunology, 2020 Sep 15; 9(1). PMID: 32923128    Free PMC article.
To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors.
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Front Immunol, 2020 Sep 26; 11. PMID: 32973794    Free PMC article.
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Time to Micromanage the Pathogen-Host-Vector Interface: Considerations for Vaccine Development.
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Vaccines (Basel), 2019 Jan 24; 7(1). PMID: 30669682    Free PMC article.
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The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status.
Eva Ott, Linda Bilonda, +15 authors, Céline Bossard.
Oncoimmunology, 2019 Mar 25; 8(4). PMID: 30906656    Free PMC article.
Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination.
Jon Amund Kyte, Anne Fåne, Martin Pule, Gustav Gaudernack.
Oncoimmunology, 2019 Mar 25; 8(4). PMID: 30906659    Free PMC article.
MiR-195 restrains lung adenocarcinoma by regulating CD4+ T cell activation via the CCDC88C/Wnt signaling pathway: a study based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and bioinformatic analysis.
Cheng Yuan, Liyang Xiang, +6 authors, Conghua Xie.
Ann Transl Med, 2019 Jul 30; 7(12). PMID: 31355230    Free PMC article.
Neoantigen-specific CD4+ T-cell response is critical for the therapeutic efficacy of cryo-thermal therapy.
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J Immunother Cancer, 2020 Sep 18; 8(2). PMID: 32938627    Free PMC article.
The Clinical Impacts of Pretreatment Peripheral Blood Ratio on Lymphocytes, Monocytes, and Neutrophils Among Patients with Laryngeal/Hypopharyngeal Cancer Treated by Chemoradiation/Radiation.
Hui-Ching Chuang, Ming-Hsien Tsai, +6 authors, Chih-Yen Chien.
Cancer Manag Res, 2020 Oct 17; 12. PMID: 33061596    Free PMC article.
Ex vivo enrichment of PRAME antigen-specific T cells for adoptive immunotherapy using CD137 activation marker selection.
Koon H Lee, Kavitha Gowrishankar, +8 authors, Emily Blyth.
Clin Transl Immunology, 2020 Oct 27; 9(10). PMID: 33101678    Free PMC article.
Combinational Immunotherapy for Hepatocellular Carcinoma: Radiotherapy, Immune Checkpoint Blockade and Beyond.
Yun Hua Lee, David Tai, +2 authors, Valerie Chew.
Front Immunol, 2020 Oct 30; 11. PMID: 33117354    Free PMC article.
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Human Immune System Mice With Autologous Tumor for Modeling Cancer Immunotherapies.
Liguang Sun, Chun-Hui Jin, +2 authors, Yong-Guang Yang.
Front Immunol, 2020 Nov 03; 11. PMID: 33133105    Free PMC article.
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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.
Junbin Qian, Siel Olbrecht, +21 authors, Diether Lambrechts.
Cell Res, 2020 Jun 21; 30(9). PMID: 32561858    Free PMC article.
A DNA-Launched Nanoparticle Vaccine Elicits CD8+ T-cell Immunity to Promote In Vivo Tumor Control.
Ziyang Xu, Neethu Chokkalingam, +10 authors, David B Weiner.
Cancer Immunol Res, 2020 Sep 12; 8(11). PMID: 32913042    Free PMC article.
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial.
Juliane Schuhmacher, Sonja Heidu, +9 authors, Cécile Gouttefangeas.
J Immunother Cancer, 2020 Nov 14; 8(2). PMID: 33184050    Free PMC article.
Dexosomes as a cell-free vaccine for cancer immunotherapy.
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J Exp Clin Cancer Res, 2020 Nov 25; 39(1). PMID: 33228747    Free PMC article.
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Unveiling the Hidden Treasury: CIITA-Driven MHC Class II Expression in Tumor Cells to Dig up the Relevant Repertoire of Tumor Antigens for Optimal Stimulation of Tumor Specific CD4+ T Helper Cells.
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Cancers (Basel), 2020 Nov 04; 12(11). PMID: 33138029    Free PMC article.
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Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
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IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity.
Hidekazu Shirota, Dennis M Klinman, +3 authors, Chikashi Ishioka.
Cancer Immunol Res, 2016 Dec 07; 5(1). PMID: 27920023    Free PMC article.
An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells.
Michele Tomasicchio, Lynn Semple, +14 authors, Keertan Dheda.
Cancer Immunol Immunother, 2018 Oct 05; 68(1). PMID: 30283982    Free PMC article.
Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia.
Fabio Forghieri, Giovanni Riva, +28 authors, Patrizia Comoli.
Oncotarget, 2019 Feb 21; 10(8). PMID: 30783516    Free PMC article.
The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition.
Gilda Varricchi, Stefania Loffredo, +6 authors, Maria Rosaria Galdiero.
Int J Mol Sci, 2019 Aug 16; 20(16). PMID: 31412566    Free PMC article.
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Personal Neoantigen Cancer Vaccines: A Road Not Fully Paved.
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Cancer Immunol Res, 2020 Dec 03; 8(12). PMID: 33262163    Free PMC article.
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Systemic CD4 Immunity as a Key Contributor to PD-L1/PD-1 Blockade Immunotherapy Efficacy.
Miren Zuazo, Hugo Arasanz, +5 authors, David Escors.
Front Immunol, 2020 Dec 18; 11. PMID: 33329566    Free PMC article.
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Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors.
Phonphimon Wongthida, Matthew R Schuelke, +10 authors, Richard G Vile.
Neuro Oncol, 2020 May 28; 22(12). PMID: 32459315    Free PMC article.
Neo-Antigen mRNA Vaccines.
Arthur Esprit, Wout de Mey, +3 authors, Karine Breckpot.
Vaccines (Basel), 2020 Dec 24; 8(4). PMID: 33353155    Free PMC article.
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Gamma-radiated immunosuppressed tumor xenograft mice can be a new ideal model in cancer research.
Hamid Khodayari, Saeed Khodayari, +8 authors, Ali Mohammad Alizadeh.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420261    Free PMC article.
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy.
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J Leukoc Biol, 2020 Mar 15; 107(4). PMID: 32170883    Free PMC article.
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The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.
Yashwanth Subbannayya, Markus Haug, +5 authors, Richard K Kandasamy.
Int J Mol Sci, 2021 Jan 02; 22(1). PMID: 33383959    Free PMC article.
CD4+ T cell exhaustion leads to adoptive transfer therapy failure which can be prevented by immune checkpoint blockade.
Jinfei Fu, Anze Yu, +4 authors, Bin He.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33414997    Free PMC article.
The Tumor Microenvironment and Immunotherapy of Oropharyngeal Squamous Cell Carcinoma.
Marij J P Welters, Saskia J Santegoets, Sjoerd H van der Burg.
Front Oncol, 2021 Jan 12; 10. PMID: 33425717    Free PMC article.
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Amygdalin promotes the activity of T cells to suppress the progression of HBV-related hepatocellular carcinoma via the JAK2/STAT3 signaling pathway.
Ruoyu Wang, Dong Zhang, +5 authors, Yunan Wu.
BMC Infect Dis, 2021 Jan 14; 21(1). PMID: 33435880    Free PMC article.
Domain binding and isotype dictate the activity of anti-human OX40 antibodies.
Jordana Griffiths, Khiyam Hussain, +18 authors, Mark S Cragg.
J Immunother Cancer, 2021 Jan 12; 8(2). PMID: 33428585    Free PMC article.
Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.
Ryusuke Hayashi, Toshihiro Nagato, +18 authors, Hiroya Kobayashi.
Oncoimmunology, 2021 Jan 19; 10(1). PMID: 33457076    Free PMC article.
Advances in the development of personalized neoantigen-based therapeutic cancer vaccines.
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Nat Rev Clin Oncol, 2021 Jan 22; 18(4). PMID: 33473220    Free PMC article.
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Bombyx batryticatus Protein-Rich Extract Induces Maturation of Dendritic Cells and Th1 Polarization: A Potential Immunological Adjuvant for Cancer Vaccine.
Ha-Yeon Song, Jeong Moo Han, +3 authors, Eui-Baek Byun.
Molecules, 2021 Jan 23; 26(2). PMID: 33477499    Free PMC article.
EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4+ T cells in chronic lymphocytic leukemia.
Philipp M Roessner, Laura Llaó Cid, +15 authors, Martina Seiffert.
Leukemia, 2021 Feb 03; 35(8). PMID: 33526861    Free PMC article.
Modulation of CD4 T Cell Response According to Tumor Cytokine Microenvironment.
Théo Accogli, Mélanie Bruchard, Frédérique Végran.
Cancers (Basel), 2021 Jan 28; 13(3). PMID: 33498483    Free PMC article.
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CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs.
Deborah K Johnson, Wyatt Magoffin, +6 authors, K Scott Weber.
Front Immunol, 2021 Feb 06; 11. PMID: 33542711    Free PMC article.
Revisiting the role of CD4+ T cells in cancer immunotherapy-new insights into old paradigms.
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Cancer Gene Ther, 2020 May 28; 28(1-2). PMID: 32457487    Free PMC article.
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Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms.
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Front Oncol, 2021 Feb 23; 10. PMID: 33614478    Free PMC article.
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CD4+ T Cells: Multitasking Cells in the Duty of Cancer Immunotherapy.
Jennifer R Richardson, Anna Schöllhorn, Cécile Gouttefangeas, Juliane Schuhmacher.
Cancers (Basel), 2021 Feb 07; 13(4). PMID: 33546283    Free PMC article.
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Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment.
Rongqun Guo, Mengdie Lü, +16 authors, Zhongxing Jiang.
Biomark Res, 2021 Mar 03; 9(1). PMID: 33648605    Free PMC article.
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control.
Claire Lhuillier, Nils-Petter Rudqvist, +9 authors, Sandra Demaria.
J Clin Invest, 2021 Jan 22; 131(5). PMID: 33476307    Free PMC article.
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Amélie Cachot, Mariia Bilous, +22 authors, Camilla Jandus.
Sci Adv, 2021 Feb 28; 7(9). PMID: 33637530    Free PMC article.
The Peptide Vaccine of the Future.
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Mol Cell Proteomics, 2021 Feb 16; 20. PMID: 33583769    Free PMC article.
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Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
Deena M Maurer, Juraj Adamik, +5 authors, Lisa H Butterfield.
Cancer Immunol Res, 2020 Oct 15; 8(12). PMID: 33051240    Free PMC article.
Interleukin-33 modulates immune responses in cutaneous melanoma in a context-specific way.
Liang Peng, Wei Sun, +2 authors, Weiping Wen.
Aging (Albany NY), 2021 Feb 24; 13(5). PMID: 33621202    Free PMC article.
Harnessing the IL-21-BATF Pathway in the CD8+ T Cell Anti-Tumor Response.
Paytsar Topchyan, Gang Xin, +7 authors, Weiguo Cui.
Cancers (Basel), 2021 Apr 04; 13(6). PMID: 33809259    Free PMC article.
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy.
Benedetta Apollonio, Nikolaos Ioannou, Despoina Papazoglou, Alan G Ramsay.
Front Oncol, 2021 Apr 13; 11. PMID: 33842331    Free PMC article.
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Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.
Michihisa Kono, Takumi Kumai, +14 authors, Yasuaki Harabuchi.
Cancer Immunol Immunother, 2021 Apr 19; 70(12). PMID: 33866408
Default polyfunctional T helper 1 response to ample signal 1 alone.
Luca Danelli, Georgina Cornish, Julia Merkenschlager, George Kassiotis.
Cell Mol Immunol, 2020 Apr 22; 18(7). PMID: 32313208    Free PMC article.
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges.
Christos Nikolaou, Kerstin Muehle, +5 authors, Andreas Thiel.
Immun Ageing, 2021 Apr 22; 18(1). PMID: 33879187    Free PMC article.
Opposing Roles of Type I Interferons in Cancer Immunity.
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Nat Rev Cancer, 2021 Apr 29; 21(6). PMID: 33907315
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Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk Neuroblastoma.
Xao X Tang, Hiroyuki Shimada, Naohiko Ikegaki.
Front Immunol, 2021 May 11; 12. PMID: 33968044    Free PMC article.
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.
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Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34064410    Free PMC article.
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Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors.
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Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6.
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Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity.
Zhi-Chun Ding, Huidong Shi, +11 authors, Gang Zhou.
Sci Immunol, 2020 Nov 01; 5(52). PMID: 33127608    Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
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Double-edged effects of interferons on the regulation of cancer-immunity cycle.
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Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines.
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Front Immunol, 2021 Jul 20; 12. PMID: 34276688    Free PMC article.
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Inhibition of Orthotopic Genital Cancer Induced by Subcutaneous Administration of Human Papillomavirus Peptide Vaccine with CpG Oligodeoxynucleotides as an Adjuvant in Mice.
Huan Wang, Yuxin Che, +2 authors, Xuelian Wang.
Cancer Manag Res, 2021 Jul 22; 13. PMID: 34285577    Free PMC article.
Neoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy.
Suangson Supabphol, Lijin Li, S Peter Goedegebuure, William E Gillanders.
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MS-Based HLA-II Peptidomics Combined With Multiomics Will Aid the Development of Future Immunotherapies.
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Mol Cell Proteomics, 2021 Jun 20; 20. PMID: 34146720    Free PMC article.
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MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data.
Siyao Liu, Aatish Thennavan, +2 authors, Charles M Perou.
Genome Biol, 2021 Aug 21; 22(1). PMID: 34412669    Free PMC article.
Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells.
Seon-Hee Kim, Eunjung Cho, +3 authors, Byoung S Kwon.
Nat Commun, 2021 Sep 09; 12(1). PMID: 34493727    Free PMC article.
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma.
Juliette Paillet, Céleste Plantureux, +33 authors, Jonathan G Pol.
J Exp Med, 2021 Sep 09; 218(10). PMID: 34495298    Free PMC article.
Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia.
Fabio Forghieri, Giovanni Riva, +22 authors, Mario Luppi.
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Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation.
Cory J Knudson, Maria Férez, +5 authors, Luis J Sigal.
J Virol, 2021 Jul 15; 95(19). PMID: 34260270    Free PMC article.
High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity.
Rosmely Hernandez, Kathryn M LaPorte, +2 authors, Thomas R Malek.
J Immunother Cancer, 2021 Sep 04; 9(9). PMID: 34475132    Free PMC article.
ERK Inhibition Improves Anti-PD-L1 Immune Checkpoint Blockade in Preclinical Pancreatic Ductal Adenocarcinoma.
Kelly E Henry, Kyeara N Mack, +7 authors, Jason S Lewis.
Mol Cancer Ther, 2021 Aug 06; 20(10). PMID: 34349003    Free PMC article.
Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4+ T Cells in the Central Region of pMMR CRC.
Jingwen Qi, Xiaoyan Liu, +14 authors, Wei Yang.
Front Oncol, 2021 Oct 12; 11. PMID: 34631551    Free PMC article.
Immunity beyond cancer cells: perspective from tumor tissue.
Shengyu Gao, Ting-Wei Hsu, Ming O Li.
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Supplementation with Serum-Derived Extracellular Vesicles Reinforces Antitumor Immunity Induced by Cryo-Thermal Therapy.
Yinuo Cen, Yue Lou, +4 authors, Ping Liu.
Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681680    Free PMC article.
CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?
Alexandra M Miggelbrink, Joshua D Jackson, +4 authors, Peter E Fecci.
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Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors.
Sophia Schreiber, Melanie Honz, +8 authors, Karin Wisskirchen.
Mol Ther Methods Clin Dev, 2021 Dec 03; 23. PMID: 34853796    Free PMC article.
Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses.
Peter Symonds, Ana Marcu, +3 authors, Victoria A Brentville.
Front Immunol, 2021 Dec 04; 12. PMID: 34858415    Free PMC article.
Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response.
Margaux Vienne, Marion Etiennot, +6 authors, Yann M Kerdiles.
Front Immunol, 2021 Dec 07; 12. PMID: 34868026    Free PMC article.
Differential Role of PD-1 Expressed by Various Immune and Tumor Cells in the Tumor Immune Microenvironment: Expression, Function, Therapeutic Efficacy, and Resistance to Cancer Immunotherapy.
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Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
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J Immunother Cancer, 2021 Dec 03; 9(12). PMID: 34853180    Free PMC article.
Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.
Eva-Maria Surmann, Anita Y Voigt, +5 authors, Matthias Kloor.
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Chemokines in the Landscape of Cancer Immunotherapy: How They and Their Receptors Can Be Used to Turn Cold Tumors into Hot Ones?
Nathan Karin.
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Immune Modulatory Properties of Collagen in Cancer.
Anne Mette Askehøj Rømer, Marie-Louise Thorseth, Daniel Hargbøl Madsen.
Front Immunol, 2021 Dec 28; 12. PMID: 34956223    Free PMC article.
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What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy?
Qingyi Wang, Bin Xie, +4 authors, Wenxiang Wang.
Front Immunol, 2022 Jan 11; 12. PMID: 35003090    Free PMC article.
Review.
Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma.
Michihisa Kono, Hiroki Komatsuda, +13 authors, Yasuaki Harabuchi.
Oncoimmunology, 2022 Jan 11; 11(1). PMID: 35003900    Free PMC article.
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy.
Myriam Ben Khelil, Yann Godet, +3 authors, Romain Loyon.
Cancers (Basel), 2022 Jan 12; 14(1). PMID: 35008422    Free PMC article.
Review.
Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma.
Mona O Mohsen, Daniel E Speiser, +9 authors, Martin F Bachmann.
J Immunother Cancer, 2022 Jan 13; 10(1). PMID: 35017147    Free PMC article.
Factors Determining Long-Term Antitumor Responses to Immune Checkpoint Blockade Therapy in Melanoma.
Kimberly Loo, James W Smithy, Michael A Postow, Allison Betof Warner.
Front Immunol, 2022 Jan 29; 12. PMID: 35087529    Free PMC article.
Review.
Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4+ T Cells That Subvert Immunosuppression.
Shu-Chin Alicia Lai, Harika Gundlapalli, +3 authors, Alana L Welm.
Cancer Discov, 2021 Aug 01; 11(12). PMID: 34330779    Free PMC article.
Identification of neoantigens for individualized therapeutic cancer vaccines.
Franziska Lang, Barbara Schrörs, +2 authors, Ugur Sahin.
Nat Rev Drug Discov, 2022 Feb 03; 21(4). PMID: 35105974    Free PMC article.
Review.
Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox.
David Y Oh, Lawrence Fong.
Immunity, 2021 Dec 16; 54(12). PMID: 34910940    Free PMC article.
Review.
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack.
Abhishek Guha, Saboora Waris, +4 authors, Peter H King.
Adv Drug Deliv Rev, 2021 Dec 20; 181. PMID: 34923029    Free PMC article.
Review.
Identification of Neoantigens in Cancer Cells as Targets for Immunotherapy.
Masahiro Okada, Kanako Shimizu, Shin-Ichiro Fujii.
Int J Mol Sci, 2022 Mar 11; 23(5). PMID: 35269735    Free PMC article.
Review.
CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer.
Caitlin E Egan, Dessislava Stefanova, +13 authors, Irene M Min.
Thyroid, 2021 Jun 04; 31(10). PMID: 34078123    Free PMC article.
Messenger RNA vaccines for cancer immunotherapy: progress promotes promise.
Amanda L Huff, Elizabeth M Jaffee, Neeha Zaidi.
J Clin Invest, 2022 Mar 16; 132(6). PMID: 35289317    Free PMC article.
Review.
The role of CD4 T cells in rejection of solid tumors.
Lucia Poncette, Julia Bluhm, Thomas Blankenstein.
Curr Opin Immunol, 2021 Oct 08; 74. PMID: 34619457    Free PMC article.
Review.
CD5 Deficiency Alters Helper T Cell Metabolic Function and Shifts the Systemic Metabolome.
Kiara V Whitley, Claudia M Tellez Freitas, +6 authors, K Scott Weber.
Biomedicines, 2022 Mar 26; 10(3). PMID: 35327505    Free PMC article.
IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40.
Lili Chen, Zhengxiang He, +7 authors, Sergio A Lira.
Cell Mol Immunol, 2022 Apr 27;. PMID: 35468944
Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
Giacomo Oliveira, Kari Stromhaug, +24 authors, Catherine J Wu.
Nature, 2022 May 05; 605(7910). PMID: 35508657
High GILT Expression Is Associated with Improved Survival in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibition.
Anngela C Adams, Elizabeth S Borden, +9 authors, Karen Taraszka Hastings.
Cancers (Basel), 2022 May 15; 14(9). PMID: 35565329    Free PMC article.
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function.
Joshua R Veatch, Sylvia M Lee, +19 authors, Stanley R Riddell.
Cancer Cell, 2022 Apr 13; 40(4). PMID: 35413271    Free PMC article.
Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination.
Rodrigo Nalio Ramos, Caroline Tosch, +20 authors, Karola Rittner.
Clin Transl Immunology, 2022 May 17; 11(5). PMID: 35573979    Free PMC article.