Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Sergio A Quezada ¹, Tyler R Simpson , Karl S Peggs , Taha Merghoub , Jelena Vider , Xiaozhou Fan , Ronald Blasberg , Hideo Yagita , Pawel Muranski , Paul A Antony , Nicholas P Restifo , James P Allison

Affiliations

¹ Ludwig Center for Cancer Immunotherapy, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

PMID: 20156971
49 References
391 citations

Abstract

Adoptive transfer of large numbers of tumor-reactive CD8(+) cytotoxic T lymphocytes (CTLs) expanded and differentiated in vitro has shown promising clinical activity against cancer. However, such protocols are complicated by extensive ex vivo manipulations of tumor-reactive cells and have largely focused on CD8(+) CTLs, with much less emphasis on the role and contribution of CD4(+) T cells. Using a mouse model of advanced melanoma, we found that transfer of small numbers of naive tumor-reactive CD4(+) T cells into lymphopenic recipients induces substantial T cell expansion, differentiation, and regression of large established tumors without the need for in vitro manipulation. Surprisingly, CD4(+) T cells developed cytotoxic activity, and tumor rejection was dependent on class II-restricted recognition of tumors by tumor-reactive CD4(+) T cells. Furthermore, blockade of the coinhibitory receptor CTL-associated antigen 4 (CTLA-4) on the transferred CD4(+) T cells resulted in greater expansion of effector T cells, diminished accumulation of tumor-reactive regulatory T cells, and superior antitumor activity capable of inducing regression of spontaneous mouse melanoma. These findings suggest a novel potential therapeutic role for cytotoxic CD4(+) T cells and CTLA-4 blockade in cancer immunotherapy, and demonstrate the potential advantages of differentiating tumor-reactive CD4(+) cells in vivo over current protocols favoring in vitro expansion and differentiation.

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Induction of HCA587-specific antitumor immunity with HCA587 protein formulated with CpG and ISCOM in mice. Juanjuan Chen, Lijie Zhang, +5 authors, Yanhui Yin. less PLoS One, 2012 Oct 17; 7(10). PMID: 23071764 Free PMC article.
Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras. Hui Wang, Yanping Yang, +4 authors, Yong-Guang Yang. less PLoS One, 2012 Oct 19; 7(10). PMID: 23077554 Free PMC article.
Anti-tumor immunity: myeloid leukocytes control the immune landscape. Melanie R Rutkowski, Tom L Stephen, Jose R Conejo-Garcia. Cell Immunol, 2012 Nov 06; 278(1-2). PMID: 23121972 Free PMC article. Review.
A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. Lifeng Wang, Bangxing Hong, +3 authors, Xue F Huang. less PLoS One, 2012 Nov 13; 7(11). PMID: 23145026 Free PMC article.
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors. Jing Ni, Matthias Miller, +2 authors, Ana Stojanovic, Natalio Garbi, Adelheid Cerwenka. less J Exp Med, 2012 Dec 05; 209(13). PMID: 23209317 Free PMC article. Highly Cited.
Effector CD4 and CD8 T cells and their role in the tumor microenvironment. Sine Hadrup, Marco Donia, Per Thor Straten. Cancer Microenviron, 2012 Dec 18; 6(2). PMID: 23242673 Free PMC article.
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion. Marie-Clare St Rose, Roslyn A Taylor, +4 authors, Adam J Adler. less Immunol Cell Biol, 2013 Jan 09; 91(2). PMID: 23295363 Free PMC article.
ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells. J Ludovic Croxford, Melissa Li Fang Tang, +7 authors, Stephan Gasser. less Blood, 2013 Jan 26; 121(13). PMID: 23349395 Free PMC article.
Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells. Eric D Mortenson, SaeGwang Park, +2 authors, Zhujun Jiang, Shengdian Wang, Yang-Xin Fu. less Clin Cancer Res, 2013 Feb 01; 19(6). PMID: 23363817 Free PMC article.
Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response. Michel DuPage, Tyler Jacks. Curr Opin Immunol, 2013 Mar 08; 25(2). PMID: 23465466 Free PMC article. Review.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation. Adam J Adler, Anthony T Vella. Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891 Free PMC article.
Human MHC Class I-restricted high avidity CD4+ T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. Shao-An Xue, Liquan Gao, +9 authors, Hans J Stauss. less Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23483821 Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Mark J Dobrzanski. Front Oncol, 2013 Mar 28; 3. PMID: 23533029 Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma. Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony. less J Immunol, 2013 Mar 29; 190(9). PMID: 23536636 Free PMC article. Highly Cited.
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. Michael A Curran, Theresa L Geiger, +5 authors, James P Allison. less J Exp Med, 2013 Apr 03; 210(4). PMID: 23547098 Free PMC article. Highly Cited.
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies. Konstantinos Liapis, Andrew Clear, +6 authors, John G Gribben. less Blood, 2013 May 09; 122(3). PMID: 23652804 Free PMC article.
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors. Paul Spear, Amorette Barber, Charles L Sentman. Oncoimmunology, 2013 Jun 05; 2(4). PMID: 23734311 Free PMC article.
Early in vivo signaling profiles in MUC1-specific CD4+ T cells responding to two different MUC1-targeting vaccines in two different microenvironments. Dawn K Reichenbach, Olivera J Finn. Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802084 Free PMC article.
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Michael Kalos, Carl H June. Immunity, 2013 Jul 31; 39(1). PMID: 23890063 Free PMC article. Highly Cited. Review.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada. less J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981 Free PMC article. Highly Cited.
Low immunogenicity of neural progenitor cells differentiated from induced pluripotent stem cells derived from less immunogenic somatic cells. Pengfei Liu, Shubin Chen, +10 authors, Duanqing Pei. less PLoS One, 2013 Aug 08; 8(7). PMID: 23922758 Free PMC article.
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies. Jennifer D Stone, David M Kranz. Front Immunol, 2013 Aug 24; 4. PMID: 23970885 Free PMC article.
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. Laiqing Hua, Shuyu Yao, +7 authors, Jie Sun. less J Virol, 2013 Aug 30; 87(21). PMID: 23986597 Free PMC article.
Changing T-cell enigma: cancer killing or cancer control? Thomas Wieder, Heidi Braumüller, +2 authors, Ellen Brenner, Lars Zender, Martin Röcken. less Cell Cycle, 2013 Sep 10; 12(19). PMID: 24013429 Free PMC article.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy. Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría. less Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells. Sarah E Church, Shawn M Jensen, +2 authors, Paul A Antony, Nicholas P Restifo, Bernard A Fox. less Eur J Immunol, 2013 Oct 12; 44(1). PMID: 24114780 Free PMC article.
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. Paula D Bos, George Plitas, +2 authors, Dipayan Rudra, Sue Y Lee, Alexander Y Rudensky. less J Exp Med, 2013 Oct 16; 210(11). PMID: 24127486 Free PMC article. Highly Cited.
Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth. Matthias Hardtke-Wolenski, Lilli Kraus, +7 authors, Thorsten Lieke. less PLoS One, 2013 Nov 10; 8(10). PMID: 24205259 Free PMC article.
Human cell-based artificial antigen-presenting cells for cancer immunotherapy. Marcus O Butler, Naoto Hirano. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329798 Free PMC article. Review.
Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers. Arnab Ghosh, Amanda M Holland, Marcel R M van den Brink. Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329800 Free PMC article. Review.
Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapy. Michal Kuczma, Agnieszka Kurczewska, Piotr Kraj. J Immunotoxicol, 2013 Dec 20; 11(4). PMID: 24350726 Free PMC article.
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. Liufu Deng, Hua Liang, +4 authors, Yang-Xin Fu. less J Clin Invest, 2014 Jan 03; 124(2). PMID: 24382348 Free PMC article. Highly Cited.
Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens. Junji Yatsuda, Atsushi Irie, +14 authors, Yasuharu Nishimura. less PLoS One, 2014 Jan 05; 8(12). PMID: 24386437 Free PMC article.
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients. Shigehisa Kitano, Takemasa Tsuji, +7 authors, Jedd D Wolchok. less Cancer Immunol Res, 2014 Jan 08; 1(4). PMID: 24396833 Free PMC article.
TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. Mohammad N Uddin, Yubin Zhang, +2 authors, Dorina Avram. less J Immunol, 2014 Jan 22; 192(4). PMID: 24446520 Free PMC article.
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. Zulkarnain Harfuddin, Shaqireen Kwajah, +2 authors, Herbert Schwarz. less Oncoimmunology, 2014 Feb 01; 2(11). PMID: 24482752 Free PMC article.
Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody. Bryan D Choi, Patrick C Gedeon, +6 authors, John H Sampson. less Cancer Immunol Res, 2014 Feb 27; 1(3). PMID: 24570975 Free PMC article.
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Thinle Chodon, Begoña Comin-Anduix, +31 authors, Antoni Ribas. less Clin Cancer Res, 2014 Mar 19; 20(9). PMID: 24634374 Free PMC article. Highly Cited.
Immunization with a peptide containing MHC class I and II epitopes derived from the tumor antigen SIM2 induces an effective CD4 and CD8 T-cell response. Haydn T Kissick, Martin G Sanda, Laura K Dunn, Mohamed S Arredouani. PLoS One, 2014 Apr 03; 9(4). PMID: 24690990 Free PMC article.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex. Emily B Heikamp, Chirag H Patel, +10 authors, Jonathan D Powell. less Nat Immunol, 2014 Apr 08; 15(5). PMID: 24705297 Free PMC article. Highly Cited.
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules? Ole Audun Werner Haabeth, Anders Aune Tveita, +8 authors, Bjarne Bogen. less Front Immunol, 2014 May 02; 5. PMID: 24782871 Free PMC article. Highly Cited. Review.
Implementing combinatorial immunotherapeutic regimens against cancer: The concept of immunological conditioning. Dominik Wolf, Annkristin Heine, Peter Brossart. Oncoimmunology, 2014 May 07; 3(1). PMID: 24800168 Free PMC article. Review.
Variability in CRP, regulatory T cells and effector T cells over time in gynaecological cancer patients: a study of potential oscillatory behaviour and correlations. Mutsa T Madondo, Sandra Tuyaerts, +6 authors, Magdalena Plebanski. less J Transl Med, 2014 Jun 25; 12. PMID: 24957270 Free PMC article.
HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Jacob Couturier, Alexander T Hutchison, +11 authors, Dorothy E Lewis. less Virology, 2014 Jul 08; 462-463. PMID: 24999042 Free PMC article.
A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy. Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong. J Immunol Res, 2014 Jul 11; 2014. PMID: 25009822 Free PMC article. Review.
A vaccine targeting mutant IDH1 induces antitumour immunity. Theresa Schumacher, Lukas Bunse, +24 authors, Michael Platten. less Nature, 2014 Jul 22; 512(7514). PMID: 25043048 Highly Cited.
Dasatinib promotes Th1-type responses in granzyme B expressing T-cells. Anna Kreutzman, Mette Ilander, +2 authors, Kimmo Porkka, Jukka Vakkila, Satu Mustjoki. less Oncoimmunology, 2014 Aug 02; 3. PMID: 25083322 Free PMC article.
TGFβ in T cell biology and tumor immunity: Angel or devil? Eric Tu, Pei Zhi Cheryl Chia, Wanjun Chen. Cytokine Growth Factor Rev, 2014 Aug 27; 25(4). PMID: 25156420 Free PMC article. Review.
Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells. Lin Lin, Jacob Couturier, +3 authors, Dorothy E Lewis. less BMC Immunol, 2014 Sep 24; 15. PMID: 25245659 Free PMC article.
CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic. Michael L Freeman, Claire E Burkum, +11 authors, Marcia A Blackman. less J Immunol, 2014 Nov 08; 193(12). PMID: 25378595 Free PMC article.
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Carsten Linnemann, Marit M van Buuren, +13 authors, Ton N M Schumacher. less Nat Med, 2014 Dec 23; 21(1). PMID: 25531942 Highly Cited.
Proximity ligation assay evaluates IDH1R132H presentation in gliomas. Lukas Bunse, Theresa Schumacher, +13 authors, Michael Platten. less J Clin Invest, 2015 Jan 03; 125(2). PMID: 25555220 Free PMC article.
Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells. Xiaoyun Lu, Zhi-Chun Ding, +8 authors, Gang Zhou. less J Immunol, 2015 Jan 07; 194(4). PMID: 25560408 Free PMC article.
Metastatic melanoma cells evade immune detection by silencing STAT1. JoDi Lynn Osborn, Susanna F Greer. Int J Mol Sci, 2015 Feb 19; 16(2). PMID: 25690042 Free PMC article.
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma. Yong Zheng, Greg Parsonage, +7 authors, Steven P Lee. less Cancer Immunol Res, 2015 Feb 26; 3(10). PMID: 25711537 Free PMC article.
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells. Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan. less Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538 Free PMC article.
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy. Edward J Wyluda, Jihua Cheng, +8 authors, Joseph J Drabick. less Cancer Biol Ther, 2015 Mar 26; 16(5). PMID: 25806780 Free PMC article.
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma. Serena Pellegatta, Lorella Valletta, +8 authors, Gaetano Finocchiaro. less Acta Neuropathol Commun, 2015 Apr 08; 3. PMID: 25849072 Free PMC article.
An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen. Matthew P Rausch, Karen Taraszka Hastings. PLoS One, 2015 Apr 16; 10(4). PMID: 25875653 Free PMC article.
Limitations of bystander killing in Th1/M1 immune responses against a secreted tumor antigen. Anders Aune Tveita, Ole Audun Haabeth, Bjarne Bogen. Oncoimmunology, 2015 May 06; 3(9). PMID: 25941607 Free PMC article.
An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy. Neeraj Lal, Andrew D Beggs, Benjamin E Willcox, Gary W Middleton. Oncoimmunology, 2015 May 08; 4(3). PMID: 25949894 Free PMC article.
Autologous cellular vaccine overcomes cancer immunoediting in a mouse model of myeloma. Marta Mazzocco, Matteo Martini, +12 authors, Silvia Sartoris. less Immunology, 2015 May 12; 146(1). PMID: 25959091 Free PMC article.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity. Yunfei Zhang, Yong Zhang, +2 authors, Jun Chen, Yunyan Liu, Wen Luo. less PLoS One, 2015 May 12; 10(5). PMID: 25961716 Free PMC article.
Mutant IDH1: An immunotherapeutic target in tumors. Theresa Schumacher, Lukas Bunse, Wolfgang Wick, Michael Platten. Oncoimmunology, 2015 May 13; 3(12). PMID: 25964867 Free PMC article.
The role of the tumor microenvironment in HIV-associated lymphomas. Joseph G Taylor, Konstantinos Liapis, John G Gribben. Biomark Med, 2015 May 20; 9(5). PMID: 25985176 Free PMC article. Review.
Cancer immunotherapy: exploiting neoepitopes. Michael Platten, Rienk Offringa. Cell Res, 2015 Jun 03; 25(8). PMID: 26032267 Free PMC article.
EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells. Laura Pisapia, Pasquale Barba, +3 authors, Giovanna Del Pozzo. less Int J Oncol, 2015 Jun 18; 47(2). PMID: 26081906 Free PMC article.
Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition. Maud Condomines, Jon Arnason, +3 authors, Michel Sadelain. less PLoS One, 2015 Jun 26; 10(6). PMID: 26110267 Free PMC article.
Rapid generation of NY-ESO-1-specific CD4+ THELPER1 cells for adoptive T-cell therapy. Simone Kayser, Cristina Boβ, +11 authors, Tobias Feuchtinger. less Oncoimmunology, 2015 Jul 15; 4(5). PMID: 26155389 Free PMC article.
Clinical Development of Immune Checkpoint Inhibitors. Ayumu Ito, Shunsuke Kondo, Kohei Tada, Shigehisa Kitano. Biomed Res Int, 2015 Jul 15; 2015. PMID: 26161407 Free PMC article. Review.
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity. Daniela Weiskopf, Derek J Bangs, +6 authors, Alessandro Sette. less Proc Natl Acad Sci U S A, 2015 Jul 22; 112(31). PMID: 26195744 Free PMC article. Highly Cited.
Therapeutic cancer vaccines. Cornelis J M Melief, Thorbald van Hall, +2 authors, Ramon Arens, Ferry Ossendorp, Sjoerd H van der Burg. less J Clin Invest, 2015 Jul 28; 125(9). PMID: 26214521 Free PMC article. Highly Cited. Review.
Identification of novel Lck-derived T helper epitope long peptides applicable for HLA-A2(+) cancer patients as cancer vaccine. Satoko Matsueda, Shigeki Shichijo, +4 authors, Kyogo Itoh. less Cancer Sci, 2015 Sep 04; 106(11). PMID: 26331453 Free PMC article.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine. Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi. Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591 Free PMC article. Review.
CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity. G Elizabeth Pluhar, Christopher A Pennell, Michael R Olin. Crit Rev Immunol, 2015 Sep 10; 35(2). PMID: 26351148 Free PMC article. Review.
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells. Mamoru Kawahara, Hiroshi Takaku. Cancer Biol Ther, 2015 Sep 24; 16(11). PMID: 26391871 Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells. Kyle A Wilson, Stephen R Goding, +2 authors, Harold R Neely, Kristina M Harris, Paul Andrew Antony. less Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570 Free PMC article.
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses. Junko Matsuzaki, Takemasa Tsuji, +7 authors, Kunle Odunsi. less Sci Rep, 2015 Oct 09; 5. PMID: 26447332 Free PMC article.
IL-1βR-dependent priming of antitumor CD4+ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria. Sabine Kuhn, Jianping Yang, +3 authors, Franca Ronchese. less Oncoimmunology, 2015 Oct 10; 4(10). PMID: 26451307 Free PMC article.
T-cell receptor gene therapy--ready to go viral? Terhi Karpanen, Johanna Olweus. Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533 Free PMC article. Review.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy. Payal Mittal, Marie-Clare St Rose, +4 authors, Adam J Adler. less J Immunol, 2015 Nov 13; 195(12). PMID: 26561553 Free PMC article.
Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy. Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong. J Immunol Res, 2015 Nov 19; 2015. PMID: 26579545 Free PMC article. Review.
Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut. Yunji Park, Sook-Jin Moon, Seung-Woo Lee. BMB Rep, 2015 Nov 26; 49(1). PMID: 26592937 Free PMC article. Review.
Melanoma: oncogenic drivers and the immune system. Niki Karachaliou, Sara Pilotto, +10 authors, Rafael Rosell. less Ann Transl Med, 2015 Nov 26; 3(18). PMID: 26605311 Free PMC article. Review.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage. Arata Takeuchi, Mohamed El Sherif Gadelhaq Badr, +11 authors, Takashi Saito. less J Exp Med, 2015 Dec 24; 213(1). PMID: 26694968 Free PMC article.
Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells. Maurizio Perdicchio, Lenneke A M Cornelissen, +6 authors, Wendy W J Unger. less Oncotarget, 2016 Jan 08; 7(8). PMID: 26741508 Free PMC article.
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion. Nicole Malandro, Sadna Budhu, +9 authors, Jedd D Wolchok. less Immunity, 2016 Jan 21; 44(1). PMID: 26789923 Free PMC article.
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. Kinga Majchrzak, Michelle H Nelson, +5 authors, Chrystal M Paulos. less Cancer Immunol Immunother, 2016 Jan 31; 65(3). PMID: 26825102 Free PMC article. Review.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth. less Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma. Jennifer Nguyen, Richard Bernert, +4 authors, K Taraszka Hastings. less Melanoma Res, 2016 Mar 02; 26(2). PMID: 26930048 Free PMC article.
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Meng-Lei Zhu, Pearl Bakhru, +6 authors, Maureen A Su. less Nat Commun, 2016 Apr 14; 7. PMID: 27072778 Free PMC article.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth. less Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060 Free PMC article.
Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma. Hongwei Xue, Fuhuang Lin, +3 authors, Ludong Zhao. less PLoS One, 2016 May 03; 11(5). PMID: 27136203 Free PMC article.
Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy. Xin Yao, Yong-Chen Lu, +8 authors, Paul F Robbins. less J Immunother, 2016 May 11; 39(5). PMID: 27163739 Free PMC article.
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity. Hidetoshi Nakagawa, Jessica M Sido, +3 authors, Hye-Jung Kim. less Proc Natl Acad Sci U S A, 2016 May 18; 113(22). PMID: 27185917 Free PMC article.
Origins of the cytolytic synapse. Maike de la Roche, Yukako Asano, Gillian M Griffiths. Nat Rev Immunol, 2016 Jun 07; 16(7). PMID: 27265595 Review.
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists. Soraya Zorro Manrique, Ana L Dominguez, +7 authors, Peter A Cohen. less Oncotarget, 2016 Jun 25; 7(28). PMID: 27341020 Free PMC article.
Modeling Human Leukemia Immunotherapy in Humanized Mice. Jinxing Xia, Zheng Hu, +7 authors, Yong-Guang Yang. less EBioMedicine, 2016 Jul 11; 10. PMID: 27394641 Free PMC article.
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model. H W Li, P Vishwasrao, +4 authors, M A Hölzl, S Chen, G Choi, G Zhao, M Sykes. less Am J Transplant, 2016 Jul 13; 17(2). PMID: 27401926 Free PMC article.
Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting. Mikko Siurala, Markus Vähä-Koskela, +6 authors, Akseli Hemminki. less Oncoimmunology, 2016 Jul 29; 5(5). PMID: 27467954 Free PMC article.
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs. Masatoshi Hirayama, Yusuke Tomita, +16 authors, Yasuharu Nishimura. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471607 Free PMC article.
The immune network in thyroid cancer. Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone. Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471646 Free PMC article. Review.
IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells. Zhi-Chun Ding, Chufeng Liu, +10 authors, Gang Zhou. less Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471650 Free PMC article.
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression. Kunyu Li, Margaret Baird, +3 authors, Sarah Young. less Clin Transl Immunology, 2016 Sep 03; 5(8). PMID: 27588200 Free PMC article.
Potential use of lymph node-derived HPV-specific T cells for adoptive cell therapy of cervical cancer. Mariëtte I E van Poelgeest, Valeria V Visconti, +10 authors, Marij J P Welters. less Cancer Immunol Immunother, 2016 Sep 14; 65(12). PMID: 27619514 Free PMC article.
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display. Anders Tveita, Marte Fauskanger, Bjarne Bogen, Ole Audun Werner Haabeth. Oncotarget, 2016 Sep 15; 7(41). PMID: 27626487 Free PMC article.
Effect of systemic injection of heterogenous and homogenous opioids on peripheral cellular immune response in rats with bone cancer pain: A comparative study. Jun-Ying Du, Yi Liang, +4 authors, Jian-Qiao Fang. less Exp Ther Med, 2016 Oct 06; 12(4). PMID: 27703511 Free PMC article.
CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade. Hongxia Yan, Xianglian Hou, +4 authors, Ruijie Zhu. less Tumour Biol, 2016 Oct 07;. PMID: 27709550
Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients. Maggie L Diller, Ragini R Kudchadkar, +2 authors, Keith A Delman, David H Lawson, Mandy L Ford. less J Immunother, 2016 Oct 16; 39(9). PMID: 27741090 Free PMC article.
Intratumoral accumulation of podoplanin-expressing lymph node stromal cells promote tumor growth through elimination of CD4+ tumor-infiltrating lymphocytes. Aikaterini Hatzioannou, Saba Nayar, +3 authors, Panayotis Verginis. less Oncoimmunology, 2016 Oct 21; 5(9). PMID: 27757315 Free PMC article.
Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8+ and CD4+ T-cell responses with multiple specificities including a novel DR7-restricted epitope. P Baumgaertner, C Costa Nunes, +15 authors, C Jandus. less Oncoimmunology, 2016 Nov 18; 5(10). PMID: 27853637 Free PMC article.
Immunostimulatory Effects of Melphalan and Usefulness in Adoptive Cell Therapy with Antitumor CD4+ T Cells. Michal Kuczma, Zhi-Chun Ding, Gang Zhou. Crit Rev Immunol, 2016 Dec 03; 36(2). PMID: 27910767 Free PMC article. Review.
Peptide vaccines in cancer-old concept revisited. Takumi Kumai, Hiroya Kobayashi, Yasuaki Harabuchi, Esteban Celis. Curr Opin Immunol, 2016 Dec 13; 45. PMID: 27940327 Free PMC article. Review.
Targeting B-cell malignancies through human B-cell receptor specific CD4+ T cells. Jinsheng Weng, Flavio Egidio Baio, +10 authors, Larry W Kwak. less Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999743 Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy. Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella. less Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531 Free PMC article. Review.
Engaging Natural Killer T Cells as 'Universal Helpers' for Vaccination. Mary Speir, Ian F Hermans, Robert Weinkove. Drugs, 2016 Dec 23; 77(1). PMID: 28005229 Review.
Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication. Ainhoa Arina, Theodore Karrison, +3 authors, Hans Schreiber. less Cancer Immunol Res, 2017 Jan 13; 5(2). PMID: 28077434 Free PMC article.
The distribution and function of human memory T cell subsets in lung cancer. Si Yuan Sheng, Yong Gu, +3 authors, RongFu Wang. less Immunol Res, 2017 Jan 20; 65(3). PMID: 28101811 Free PMC article.
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function. Arata Takeuchi, Takashi Saito. Front Immunol, 2017 Mar 11; 8. PMID: 28280496 Free PMC article. Highly Cited. Review.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein. less Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853 Free PMC article.
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. Michael S Khodadoust, Niclas Olsson, +23 authors, Ash A Alizadeh. less Nature, 2017 Mar 23; 543(7647). PMID: 28329770 Free PMC article. Highly Cited.
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response. Kun He, Ping Liu, Lisa X Xu. Cell Death Dis, 2017 Mar 24; 8(3). PMID: 28333145 Free PMC article.
Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy. Riikka Havunen, Mikko Siurala, +10 authors, Akseli Hemminki. less Mol Ther Oncolytics, 2017 Mar 28; 4. PMID: 28345026 Free PMC article.
IDO and galectin-3 hamper the ex vivo generation of clinical grade tumor-specific T cells for adoptive cell therapy in metastatic melanoma. Sara M Melief, Marten Visser, Sjoerd H van der Burg, Els M E Verdegaal. Cancer Immunol Immunother, 2017 Apr 13; 66(7). PMID: 28401257 Free PMC article.
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. Kinga Majchrzak, Michelle H Nelson, +9 authors, Chrystal M Paulos. less JCI Insight, 2017 Apr 20; 2(8). PMID: 28422756 Free PMC article.
Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma. Jacek J Sznurkowski, Anton Żawrocki, Wojciech Biernat. Oncotarget, 2017 May 19; 8(28). PMID: 28515351 Free PMC article.
Bispecific antibody does not induce T-cell death mediated by chimeric antigen receptor against disialoganglioside GD2. Sayed Shahabuddin Hoseini, Konstantin Dobrenkov, +2 authors, Dmitry Pankov, Xiaoliang L Xu, Nai-Kong V Cheung. less Oncoimmunology, 2017 Jul 07; 6(6). PMID: 28680755 Free PMC article.
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy. Rigel J Kishton, Madhusudhanan Sukumar, Nicholas P Restifo. Cell Metab, 2017 Jul 07; 26(1). PMID: 28683298 Free PMC article. Highly Cited. Review.
Vaccines targeting helper T cells for cancer immunotherapy. Marit Melssen, Craig L Slingluff. Curr Opin Immunol, 2017 Jul 30; 47. PMID: 28755541 Free PMC article. Review.
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3. Yong-Chen Lu, Linda L Parker, +14 authors, Steven A Rosenberg. less J Clin Oncol, 2017 Aug 16; 35(29). PMID: 28809608 Free PMC article. Highly Cited.
Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling. In Ah Park, Seong-Hye Hwang, +7 authors, Hee Jin Lee. less PLoS One, 2017 Aug 18; 12(8). PMID: 28817603 Free PMC article.
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Howard Y Li, Maria McSharry, +8 authors, Raphael A Nemenoff. less Cancer Immunol Res, 2017 Aug 19; 5(9). PMID: 28819064 Free PMC article.
Characterization of Demodex musculi Infestation, Associated Comorbidities, and Topographic Distribution in a Mouse Strain with Defective Adaptive Immunity. Melissa A Nashat, Kerith R Luchins, +3 authors, Neil S Lipman. less Comp Med, 2017 Aug 24; 67(4). PMID: 28830578 Free PMC article.
T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics. Z Wu, N V Cheung. Pharmacol Ther, 2017 Aug 24; 182. PMID: 28834699 Free PMC article. Review.
CIMT 2017: Anniversary symposium - Report on the 15th CIMT Annual Meeting of the Association for Cancer Immunotherapy. Lena M Kranz, Jan D Beck, +3 authors, Mustafa Diken. less Hum Vaccin Immunother, 2017 Aug 29; 13(10). PMID: 28846471 Free PMC article.
Most Do, but Some Do Not: CD4⁺CD25- T Cells, but Not CD4⁺CD25⁺ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR). Andreas A Hombach, Hinrich Abken. Cancers (Basel), 2017 Aug 30; 9(9). PMID: 28850063 Free PMC article.
Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells. Tomohiro Tanaka, Satoshi Watanabe, +20 authors, Toshiaki Kikuchi. less PLoS One, 2017 Aug 31; 12(8). PMID: 28854279 Free PMC article.
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40. David J Messenheimer, Shawn M Jensen, +6 authors, Bernard A Fox. less Clin Cancer Res, 2017 Sep 01; 23(20). PMID: 28855348 Free PMC article. Highly Cited.
Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity. Pearl Bakhru, Meng-Lei Zhu, +14 authors, Maureen A Su. less JCI Insight, 2017 Sep 22; 2(18). PMID: 28931755 Free PMC article.
Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells. Zhi-Chun Ding, Tsadik Habtetsion, +8 authors, Gang Zhou. less Sci Rep, 2017 Sep 25; 7(1). PMID: 28939858 Free PMC article.
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF. Andrea J Manrique-Rincón, Camila M Beraldo, Jessica M Toscaro, Marcio C Bajgelman. Front Immunol, 2017 Oct 05; 8. PMID: 28974950 Free PMC article.
Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression. Liesbet M Peeters, Marjan Vanheusden, +4 authors, Niels Hellings. less Front Immunol, 2017 Oct 06; 8. PMID: 28979263 Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth. Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Michael Saborowski, Florian Kühnel, Norman Woller. less Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503 Free PMC article. Review.
KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer. Neeraj Lal, Brian S White, +7 authors, Gary W Middleton. less Clin Cancer Res, 2017 Oct 25; 24(1). PMID: 29061646 Free PMC article.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions. Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu. Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133 Free PMC article.
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model. Cameron S Field, Martin K Hunn, +3 authors, Ian F Hermans. less Oncoimmunology, 2018 Jan 04; 7(1). PMID: 29296535 Free PMC article.
An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. Payal Mittal, Rebecca Abblett, +8 authors, Adam J Adler. less J Immunol, 2018 Jan 07; 200(4). PMID: 29305435 Free PMC article.
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Il-Kyu Choi, Zhe Wang, +10 authors, Baochun Zhang. less Proc Natl Acad Sci U S A, 2018 Jan 10; 115(4). PMID: 29311309 Free PMC article.
Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade. Charlotte E Ariyan, Mary Sue Brady, +19 authors, James P Allison. less Cancer Immunol Res, 2018 Jan 18; 6(2). PMID: 29339377 Free PMC article.
Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma. Joshua R Veatch, Sylvia M Lee, +10 authors, Stanley R Riddell. less J Clin Invest, 2018 Jan 24; 128(4). PMID: 29360643 Free PMC article. Highly Cited.
Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. Dmitri I Kotov, Jessica A Kotov, Michael F Goldberg, Marc K Jenkins. J Immunol, 2018 Feb 14; 200(6). PMID: 29436413 Free PMC article.
The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes. Yasmina Serroukh, Chunyan Gu-Trantien, +15 authors, Arnaud Marchant. less Elife, 2018 Mar 01; 7. PMID: 29488879 Free PMC article.
Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma. Kendra C Foley, Michael I Nishimura, Tamson V Moore. Melanoma Res, 2018 Mar 10; 28(3). PMID: 29521881 Free PMC article. Review.
Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling. Masafumi Taniwaki, Mihoko Yoshida, +3 authors, Hiroto Kaneko. less Mediterr J Hematol Infect Dis, 2018 Mar 14; 10(1). PMID: 29531651 Free PMC article. Review.
Comparison of Diagnostic Methods and Sampling Sites for the Detection of Demodex musculi. Melissa A Nashat, Rodolfo J Ricart Arbona, +4 authors, Neil S Lipman. less J Am Assoc Lab Anim Sci, 2018 Mar 21; 57(2). PMID: 29555007 Free PMC article.
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Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo. Francesca Romana Stefani, Sofia Eberstål, +2 authors, Stefano Vergani, Trine A Kristiansen, Johan Bengzon. less Int J Cancer, 2018 May 13; 143(9). PMID: 29752716 Free PMC article.
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity. Dongrui Wang, Brenda Aguilar, +6 authors, Christine E Brown. less JCI Insight, 2018 May 18; 3(10). PMID: 29769444 Free PMC article. Highly Cited.
Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity. T N Sharapova, E A Romanova, L P Sashchenko, D V Yashin. J Immunol Res, 2018 Jun 01; 2018. PMID: 29850628 Free PMC article.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial. Poulam M Patel, Christian H Ottensmeier, +15 authors, Lindy G Durrant. less Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872563 Free PMC article.
Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma. Felipe Gálvez-Cancino, Ernesto López, +11 authors, Alvaro Lladser. less Oncoimmunology, 2018 Jun 15; 7(7). PMID: 29900048 Free PMC article.
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. Themis Alissafi, Aikaterini Hatzioannou, +8 authors, Panayotis Verginis. less J Clin Invest, 2018 Jun 20; 128(9). PMID: 29920188 Free PMC article.
Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies. Vanessa M Tubb, Deborah S Schrikkema, +7 authors, Gavin M Bendle. less J Immunother Cancer, 2018 Jul 14; 6(1). PMID: 30001747 Free PMC article.
Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy. João Manuel Santos, Víctor Cervera-Carrascon, +6 authors, Akseli Hemminki. less Mol Ther, 2018 Jul 19; 26(9). PMID: 30017877 Free PMC article.
Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity. Marte Fauskanger, Ole Audun Werner Haabeth, +2 authors, Frode Miltzow Skjeldal, Bjarne Bogen, Anders Aune Tveita. less Front Immunol, 2018 Aug 08; 9. PMID: 30083157 Free PMC article.
The Paradoxical Role of NKG2D in Cancer Immunity. Sam Sheppard, Amir Ferry, Joana Guedes, Nadia Guerra. Front Immunol, 2018 Aug 29; 9. PMID: 30150983 Free PMC article. Review.
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Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity. Soyoko Morimoto, Fumihiro Fujiki, +12 authors, Haruo Sugiyama. less Oncotarget, 2018 Oct 23; 9(75). PMID: 30344927 Free PMC article.
Antigen-armed antibodies against B-cell malignancies. Marta Ilecka, Dwain G van Zyl, Henri-Jacques Delecluse. Oncotarget, 2018 Nov 28; 9(86). PMID: 30479687 Free PMC article.
Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC. Anna E Oja, Berber Piet, +8 authors, Pleun Hombrink. less Front Immunol, 2018 Dec 07; 9. PMID: 30505306 Free PMC article.
Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report. Yan Xia, Xiaopeng Tian, +10 authors, Mingjun Wang. less Oncol Lett, 2018 Dec 14; 16(6). PMID: 30546433 Free PMC article.
A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. Diana Rasoulouniriana, Nadine Santana-Magal, +11 authors, Yaron Carmi. less J Clin Invest, 2019 Aug 27; 129(10). PMID: 31449054 Free PMC article.
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. Yochai Wolf, Osnat Bartok, +26 authors, Yardena Samuels. less Cell, 2019 Sep 17; 179(1). PMID: 31522890 Free PMC article. Highly Cited.
T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity. Preeti Sharma, Daniel T Harris, Jennifer D Stone, David M Kranz. Cancer Immunol Res, 2019 Sep 25; 7(12). PMID: 31548259 Free PMC article.
High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma. Kenneth H Buetow, Lydia R Meador, +6 authors, K Taraszka Hastings. less J Immunol, 2019 Oct 09; 203(10). PMID: 31591149 Free PMC article.
Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies. Spencer C Wei, Nana-Ama A S Anang, +8 authors, James P Allison. less Proc Natl Acad Sci U S A, 2019 Oct 23; 116(45). PMID: 31636208 Free PMC article.
Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile. Rosa De Groot, Marleen M Van Loenen, +13 authors, Monika C Wolkers. less Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646094 Free PMC article.
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. Kosuke Hashimoto, Tsukasa Kouno, +17 authors, Piero Carninci. less Proc Natl Acad Sci U S A, 2019 Nov 14; 116(48). PMID: 31719197 Free PMC article.
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models. Lotte K Kristensen, Camilla Fröhlich, +8 authors, Andreas Kjaer. less Theranostics, 2019 Nov 23; 9(26). PMID: 31754392 Free PMC article.
The Ancient Chinese Decoction Yu-Ping-Feng Suppresses Orthotopic Lewis Lung Cancer Tumor Growth Through Increasing M1 Macrophage Polarization and CD4+ T Cell Cytotoxicity. Lixin Wang, Wenbin Wu, +7 authors, Shiguo Zhu. less Front Pharmacol, 2019 Nov 30; 10. PMID: 31780946 Free PMC article.
A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2. Ryota Tamura, Masato Fujioka, +14 authors, Masahiro Toda. less Nat Commun, 2019 Dec 19; 10(1). PMID: 31848332 Free PMC article.
The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies. Kroopa Joshi, Benjamin M Chain, Karl S Peggs, Sergio A Quezada. Cold Spring Harb Perspect Med, 2017 Jun 21; 8(1). PMID: 28630228 Free PMC article. Review.
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Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Mikhail Binnewies, Adriana M Mujal, +15 authors, Matthew F Krummel. less Cell, 2019 Apr 09; 177(3). PMID: 30955881 Free PMC article. Highly Cited.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells. Kazushige Yoshida, Masanori Okamoto, +13 authors, Naoto Saito. less BMC Cancer, 2020 Jan 10; 20(1). PMID: 31914969 Free PMC article.
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Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth. Jiping Wang, Jianmei W Leavenworth, +5 authors, Peter H King. less Glia, 2019 Aug 11; 67(12). PMID: 31400163 Free PMC article.
Fibrogenesis in Chronic DSS Colitis is Not Influenced by Neutralisation of Regulatory T Cells, of Major T Helper Cytokines or Absence of IL-13. Brecht Creyns, Jonathan Cremer, +7 authors, Christine Breynaert. less Sci Rep, 2019 Jul 13; 9(1). PMID: 31296924 Free PMC article.
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Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression. Lucia Poncette, Xiaojing Chen, Felix Km Lorenz, Thomas Blankenstein. J Clin Invest, 2018 Dec 12; 129(1). PMID: 30530988 Free PMC article.
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A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab. Theodore S Nowicki, Beata Berent-Maoz, +18 authors, Antoni Ribas. less Clin Cancer Res, 2018 Dec 24; 25(7). PMID: 30573690 Free PMC article.
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Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer. Vid Leko, Lucas A McDuffie, +6 authors, Yong-Chen Lu. less J Immunol, 2019 May 01; 202(12). PMID: 31036766 Free PMC article.
Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Crystal Morales Del Valle, Joseph R Maxwell, +5 authors, Anthony T Vella. less Cell Rep, 2019 May 03; 27(5). PMID: 31042471 Free PMC article.
Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer. Nithya Sivaram, Patrick A McLaughlin, +7 authors, Richard Z Lin. less J Clin Invest, 2019 May 22; 129(8). PMID: 31112530 Free PMC article.
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes. Yehezqel Elyahu, Idan Hekselman, +12 authors, Alon Monsonego. less Sci Adv, 2019 Aug 29; 5(8). PMID: 31457092 Free PMC article.
Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53. Justine Habault, Anna Kaci, +6 authors, Jean-Luc Poyet. less Oncoimmunology, 2020 Mar 12; 9(1). PMID: 32158621 Free PMC article.
Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy. Maureen A Su, Mark S Anderson. Cancer Immunol Res, 2019 Jun 05; 7(6). PMID: 31160305 Free PMC article. Review.
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. Teresa Preglej, Patricia Hamminger, +22 authors, Wilfried Ellmeier. less JCI Insight, 2020 Feb 28; 5(4). PMID: 32102981 Free PMC article.
Beyond cDC1: Emerging Roles of DC Crosstalk in Cancer Immunity. Rajkumar Noubade, Sonia Majri-Morrison, Kristin V Tarbell. Front Immunol, 2019 May 31; 10. PMID: 31143179 Free PMC article. Review.
HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy. Alexandre Couture, Anthony Garnier, +5 authors, Olivier Toutirais. less Front Immunol, 2019 Jun 04; 10. PMID: 31156634 Free PMC article. Review.
Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype. David Eisel, Krishna Das, +3 authors, Stefan B Eichmüller. less Front Immunol, 2019 Mar 12; 10. PMID: 30853959 Free PMC article.
Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model. Daniela Elgueta, Francisco Contreras, +9 authors, Rodrigo Pacheco. less Front Immunol, 2019 May 24; 10. PMID: 31118938 Free PMC article.
Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells. Marjolein Schluck, Roel Hammink, +2 authors, Carl G Figdor, Martijn Verdoes, Jorieke Weiden. less Front Immunol, 2019 May 28; 10. PMID: 31130945 Free PMC article. Review.
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases. Ping Song, Junqing An, Ming-Hui Zou. Cells, 2020 Mar 14; 9(3). PMID: 32164335 Free PMC article. Review.
Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation. Jennifer L Hope, Christopher J Stairiker, +2 authors, Eun-Ah Bae, Dennis C Otero, Linda M Bradley. less Front Immunol, 2019 Aug 06; 10. PMID: 31379821 Free PMC article. Review.
Long-term surviving cancer patients as a source of therapeutic TCR. Else Marit Inderberg, Sébastien Wälchli. Cancer Immunol Immunother, 2020 Jan 10; 69(5). PMID: 31915853 Free PMC article. Review.
Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer. Christina A Hartl, Adrian Bertschi, +5 authors, Michael S Goldberg. less J Immunother Cancer, 2019 Aug 01; 7(1). PMID: 31362778 Free PMC article.
Current issues and perspectives in PD-1 blockade cancer immunotherapy. Kenji Chamoto, Ryusuke Hatae, Tasuku Honjo. Int J Clin Oncol, 2020 Jan 05; 25(5). PMID: 31900651 Free PMC article. Review.
From Superantigens to "Real" Viral Antigens. Marcia A Blackman. Viral Immunol, 2020 Apr 15; 33(3). PMID: 32286177 Free PMC article.
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives. Xiaotong Chen, Ju Yang, Lifeng Wang, Baorui Liu. Theranostics, 2020 Jun 03; 10(13). PMID: 32483434 Free PMC article. Review.
Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications. Annalisa Del Prete, Francesca Sozio, +7 authors, Silvano Sozzani. less Int J Mol Sci, 2020 Jun 04; 21(11). PMID: 32486257 Free PMC article. Review.
CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages. Ole Audun W Haabeth, Kjartan Hennig, +3 authors, Anders Tveita. less Blood Adv, 2020 Jun 17; 4(12). PMID: 32544236 Free PMC article.
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GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen. Matthew P Rausch, Lydia R Meador, +4 authors, K Taraszka Hastings. less J Immunol, 2020 Apr 10; 204(11). PMID: 32269095 Free PMC article.
Annona muricata L.-Derived Polysaccharides as a Potential Adjuvant to a Dendritic Cell-Based Vaccine in a Thymoma-Bearing Model. Woo Sik Kim, Jeong Moo Han, +3 authors, Eui-Baek Byun. less Nutrients, 2020 Jun 04; 12(6). PMID: 32486094 Free PMC article.
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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells. Anna Śledzińska, Maria Vila de Mucha, +19 authors, Sergio A Quezada. less Immunity, 2020 Jan 12; 52(1). PMID: 31924474 Free PMC article.
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