Journal Article
. 2010 Feb; 207(3):651-67.
doi: 10.1084/jem.20091921.

Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma

Ying Xie 1 Akgül Akpinarli  Charles Maris  Edward L Hipkiss  Malcolm Lane  Eun-Kyung M Kwon  Pawel Muranski  Nicholas P Restifo  Paul Andrew Antony  
  • PMID: 20156973
  •     86 References
  •     216 citations


In vitro differentiated CD8(+) T cells have been the primary focus of immunotherapy of cancer with little focus on CD4(+) T cells. Immunotherapy involving in vitro differentiated T cells given after lymphodepleting regimens significantly augments antitumor immunity in animals and human patients with cancer. However, the mechanisms by which lymphopenia augments adoptive cell therapy and the means of properly differentiating T cells in vitro are still emerging. We demonstrate that naive tumor/self-specific CD4(+) T cells naturally differentiated into T helper type 1 cytotoxic T cells in vivo and caused the regression of established tumors and depigmentation in lymphopenic hosts. Therapy was independent of vaccination, exogenous cytokine support, CD8(+), B, natural killer (NK), and NKT cells. Proper activation of CD4(+) T cells in vivo was important for tumor clearance, as naive tumor-specific CD4(+) T cells could not completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts. gamma(c) signaling in the tumor-bearing host was important for survival and proper differentiation of adoptively transferred tumor-specific CD4(+) T cells. Thus, these data provide a platform for designing immunotherapies that incorporate tumor/self-reactive CD4(+) T cells.

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Moses K Donkor, Abira Sarkar, +5 authors, Ming O Li.
Immunity, 2011 Jul 16; 35(1). PMID: 21757379    Free PMC article.
Identification of an HLA-DPB1*0501 restricted Melan-A/MART-1 epitope recognized by CD4+ T lymphocytes: prevalence for immunotherapy in Asian populations.
Zhaoting Meng, Yadong Wang, +8 authors, Shunchang Jiao.
J Immunother, 2011 Jul 16; 34(7). PMID: 21760531    Free PMC article.
Selective expansion and enhanced anti-tumor effect of antigen-specific CD4(+) T cells by retrovirus-mediated IL-15 expression.
Jizhou Lv, Ning Tao, +4 authors, Zhihai Qin.
Protein Cell, 2011 Aug 09; 2(7). PMID: 21822803    Free PMC article.
GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.
Matthew P Rausch, K Taraszka Hastings.
J Invest Dermatol, 2011 Aug 13; 132(1). PMID: 21833020    Free PMC article.
Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.
Jang-June Park, Sudarshan Anand, +6 authors, Koji Tamada.
Cancer Immunol Immunother, 2011 Aug 31; 61(2). PMID: 21877247    Free PMC article.
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Harry Z Qui, Adam T Hagymasi, +8 authors, Adam J Adler.
J Immunol, 2011 Sep 02; 187(7). PMID: 21880986    Free PMC article.
New perspectives on the role of vitiligo in immune responses to melanoma.
Katelyn T Byrne, Mary Jo Turk.
Oncotarget, 2011 Sep 14; 2(9). PMID: 21911918    Free PMC article.
Experimental mouse tumour models: what can be learnt about human cancer immunology?
Glenn Dranoff.
Nat Rev Immunol, 2011 Dec 03; 12(1). PMID: 22134155
Cytotoxic CD4 T cells in antiviral immunity.
Nikki B Marshall, Susan L Swain.
J Biomed Biotechnol, 2011 Dec 17; 2011. PMID: 22174559    Free PMC article.
Th17 cells are long lived and retain a stem cell-like molecular signature.
Pawel Muranski, Zachary A Borman, +19 authors, Nicholas P Restifo.
Immunity, 2011 Dec 20; 35(6). PMID: 22177921    Free PMC article.
Highly Cited.
Development of a DNA vaccine targeting Merkel cell polyomavirus.
Qi Zeng, Bianca P Gomez, +5 authors, Chien-Fu Hung.
Vaccine, 2012 Jan 03; 30(7). PMID: 22210138    Free PMC article.
Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells.
Matthew J Goldstein, Holbrook E Kohrt, +4 authors, Ronald Levy.
Cancer Res, 2012 Jan 11; 72(5). PMID: 22232735    Free PMC article.
Treatment with targeted vesicular stomatitis virus generates therapeutic multifunctional anti-tumor memory CD4 T cells.
Y Gao, P Whitaker-Dowling, J A Griffin, I Bergman.
Cancer Gene Ther, 2012 Jan 14; 19(4). PMID: 22240921    Free PMC article.
Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses.
Arya Biragyn, Dan L Longo.
Semin Cancer Biol, 2012 Jan 20; 22(1). PMID: 22257681    Free PMC article.
Induction of MAGE-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma.
Caroline J Voskens, Duane Sewell, +15 authors, Scott E Strome.
Head Neck, 2012 Jan 31; 34(12). PMID: 22287423    Free PMC article.
Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81.
Yael Sagi, Angela Landrigan, Ronald Levy, Shoshana Levy.
Proc Natl Acad Sci U S A, 2012 Feb 07; 109(5). PMID: 22307619    Free PMC article.
Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.
Justin Kline, Long Zhang, +2 authors, Thomas F Gajewski.
J Immunol, 2012 Feb 09; 188(6). PMID: 22312128    Free PMC article.
Activation of a helper and not regulatory human CD4+ T cell response by oncolytic H-1 parvovirus.
Olivier Moralès, Audrey Richard, +8 authors, Nadira Delhem.
PLoS One, 2012 Feb 24; 7(2). PMID: 22359669    Free PMC article.
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Bei Wang, Neeha Zaidi, +4 authors, Ralph M Steinman.
Breast Cancer Res, 2012 Mar 09; 14(2). PMID: 22397502    Free PMC article.
Cytotoxic chemotherapy and CD4+ effector T cells: an emerging alliance for durable antitumor effects.
Zhi-Chun Ding, Gang Zhou.
Clin Dev Immunol, 2012 Mar 09; 2012. PMID: 22400040    Free PMC article.
Adoptive immunotherapy for cancer: harnessing the T cell response.
Nicholas P Restifo, Mark E Dudley, Steven A Rosenberg.
Nat Rev Immunol, 2012 Mar 23; 12(4). PMID: 22437939    Free PMC article.
Highly Cited. Review.
Immunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization.
Yuan Hong, Yibing Peng, +3 authors, Yukai He.
J Immunol, 2012 Apr 17; 188(10). PMID: 22504640    Free PMC article.
Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.
Dalya R Soond, Fabien Garçon, +5 authors, Klaus Okkenhaug.
J Immunol, 2012 May 23; 188(12). PMID: 22611241    Free PMC article.
A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth.
Frank T Wen, Ronald A Thisted, Donald A Rowley, Hans Schreiber.
Oncoimmunology, 2012 Jun 22; 1(2). PMID: 22720238    Free PMC article.
Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence.
Shawn M Jensen, Christopher G Twitty, +6 authors, Bernard A Fox.
J Immunol, 2012 Jun 23; 189(2). PMID: 22723522    Free PMC article.
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Rahul Purwar, Christoph Schlapbach, +9 authors, Thomas S Kupper.
Nat Med, 2012 Jul 10; 18(8). PMID: 22772464    Free PMC article.
Highly Cited.
A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Shikhar Mehrotra, Amir A Al-Khami, +15 authors, Michael I Nishimura.
J Immunol, 2012 Jul 17; 189(4). PMID: 22798675    Free PMC article.
NFAT1 supports tumor-induced anergy of CD4(+) T cells.
Brian T Abe, Daniel S Shin, Enric Mocholi, Fernando Macian.
Cancer Res, 2012 Aug 07; 72(18). PMID: 22865456    Free PMC article.
MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer.
Caroline Poli, Caroline Raffin, +3 authors, Danila Valmori.
Haematologica, 2012 Aug 10; 98(2). PMID: 22875619    Free PMC article.
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Carolina M Soto, Jennifer D Stone, +4 authors, David M Kranz.
Cancer Immunol Immunother, 2012 Aug 29; 62(2). PMID: 22926060    Free PMC article.
Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001.
Else-Marit Inderberg-Suso, Sissel Trachsel, +2 authors, Gustav Gaudernack.
Oncoimmunology, 2012 Aug 31; 1(5). PMID: 22934259    Free PMC article.
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype.
Daniel Hirschhorn-Cymerman, Sadna Budhu, +10 authors, Jedd D Wolchok.
J Exp Med, 2012 Sep 26; 209(11). PMID: 23008334    Free PMC article.
Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity.
Luise U Weigand, Xiaoling Liang, +8 authors, Angela M Krackhardt.
Immunology, 2012 Oct 03; 137(3). PMID: 23025755    Free PMC article.
Anti-tumor immunity: myeloid leukocytes control the immune landscape.
Melanie R Rutkowski, Tom L Stephen, Jose R Conejo-Garcia.
Cell Immunol, 2012 Nov 06; 278(1-2). PMID: 23121972    Free PMC article.
A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response.
Lifeng Wang, Bangxing Hong, +3 authors, Xue F Huang.
PLoS One, 2012 Nov 13; 7(11). PMID: 23145026    Free PMC article.
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
Jing Ni, Matthias Miller, +2 authors, Adelheid Cerwenka.
J Exp Med, 2012 Dec 05; 209(13). PMID: 23209317    Free PMC article.
Highly Cited.
CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
Marie-Clare St Rose, Roslyn A Taylor, +4 authors, Adam J Adler.
Immunol Cell Biol, 2013 Jan 09; 91(2). PMID: 23295363    Free PMC article.
ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cells.
J Ludovic Croxford, Melissa Li Fang Tang, +7 authors, Stephan Gasser.
Blood, 2013 Jan 26; 121(13). PMID: 23349395    Free PMC article.
Aire deficiency promotes TRP-1-specific immune rejection of melanoma.
Meng-Lei Zhu, Anil Nagavalli, Maureen A Su.
Cancer Res, 2013 Feb 02; 73(7). PMID: 23370329    Free PMC article.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Adam J Adler, Anthony T Vella.
Oncoimmunology, 2013 Mar 14; 2(1). PMID: 23482891    Free PMC article.
Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.
Mark J Dobrzanski.
Front Oncol, 2013 Mar 28; 3. PMID: 23533029    Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin.
Michael A Curran, Theresa L Geiger, +5 authors, James P Allison.
J Exp Med, 2013 Apr 03; 210(4). PMID: 23547098    Free PMC article.
Highly Cited.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Low immunogenicity of neural progenitor cells differentiated from induced pluripotent stem cells derived from less immunogenic somatic cells.
Pengfei Liu, Shubin Chen, +10 authors, Duanqing Pei.
PLoS One, 2013 Aug 08; 8(7). PMID: 23922758    Free PMC article.
Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.
Jennifer D Stone, David M Kranz.
Front Immunol, 2013 Aug 24; 4. PMID: 23970885    Free PMC article.
Changing T-cell enigma: cancer killing or cancer control?
Thomas Wieder, Heidi Braumüller, +2 authors, Martin Röcken.
Cell Cycle, 2013 Sep 10; 12(19). PMID: 24013429    Free PMC article.
Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.
Sarah E Church, Shawn M Jensen, +2 authors, Bernard A Fox.
Eur J Immunol, 2013 Oct 12; 44(1). PMID: 24114780    Free PMC article.
Exchange of cytosolic content between T cells and tumor cells activates CD4 T cells and impedes cancer growth.
Matthias Hardtke-Wolenski, Lilli Kraus, +7 authors, Thorsten Lieke.
PLoS One, 2013 Nov 10; 8(10). PMID: 24205259    Free PMC article.
Human cell-based artificial antigen-presenting cells for cancer immunotherapy.
Marcus O Butler, Naoto Hirano.
Immunol Rev, 2013 Dec 18; 257(1). PMID: 24329798    Free PMC article.
Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.
Junji Yatsuda, Atsushi Irie, +14 authors, Yasuharu Nishimura.
PLoS One, 2014 Jan 05; 8(12). PMID: 24386437    Free PMC article.
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients.
Shigehisa Kitano, Takemasa Tsuji, +7 authors, Jedd D Wolchok.
Cancer Immunol Res, 2014 Jan 08; 1(4). PMID: 24396833    Free PMC article.
TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.
Mohammad N Uddin, Yubin Zhang, +2 authors, Dorina Avram.
J Immunol, 2014 Jan 22; 192(4). PMID: 24446520    Free PMC article.
SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines.
Rajesh K Sharma, Esma S Yolcu, Haval Shirwan.
Expert Rev Vaccines, 2014 Feb 14; 13(3). PMID: 24521311    Free PMC article.
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Ping-Chih Ho, Katrina M Meeth, +3 authors, Susan M Kaech.
Cancer Res, 2014 Apr 17; 74(12). PMID: 24736544    Free PMC article.
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Ole Audun Werner Haabeth, Anders Aune Tveita, +8 authors, Bjarne Bogen.
Front Immunol, 2014 May 02; 5. PMID: 24782871    Free PMC article.
Highly Cited. Review.
Th17 cells in cancer: the ultimate identity crisis.
Stefanie R Bailey, Michelle H Nelson, +3 authors, Chrystal M Paulos.
Front Immunol, 2014 Jul 06; 5. PMID: 24987392    Free PMC article.
Highly Cited. Review.
A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy.
Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong.
J Immunol Res, 2014 Jul 11; 2014. PMID: 25009822    Free PMC article.
CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic.
Michael L Freeman, Claire E Burkum, +11 authors, Marcia A Blackman.
J Immunol, 2014 Nov 08; 193(12). PMID: 25378595    Free PMC article.
Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.
Xiaoyun Lu, Zhi-Chun Ding, +8 authors, Gang Zhou.
J Immunol, 2015 Jan 07; 194(4). PMID: 25560408    Free PMC article.
Breaking through the central tolerance ceiling to unleash anticancer immune responses.
Maureen A Su, Mark S Anderson.
Oncoimmunology, 2015 Jan 23; 3(8). PMID: 25610739    Free PMC article.
Metastatic melanoma cells evade immune detection by silencing STAT1.
JoDi Lynn Osborn, Susanna F Greer.
Int J Mol Sci, 2015 Feb 19; 16(2). PMID: 25690042    Free PMC article.
Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.
Ivan Liadi, Harjeet Singh, +9 authors, Navin Varadarajan.
Cancer Immunol Res, 2015 Feb 26; 3(5). PMID: 25711538    Free PMC article.
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.
Hirotake Tsukamoto, Satoru Senju, +2 authors, Yasuharu Nishimura.
Nat Commun, 2015 Apr 08; 6. PMID: 25850032    Free PMC article.
An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen.
Matthew P Rausch, Karen Taraszka Hastings.
PLoS One, 2015 Apr 16; 10(4). PMID: 25875653    Free PMC article.
Limitations of bystander killing in Th1/M1 immune responses against a secreted tumor antigen.
Anders Aune Tveita, Ole Audun Haabeth, Bjarne Bogen.
Oncoimmunology, 2015 May 06; 3(9). PMID: 25941607    Free PMC article.
An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.
Neeraj Lal, Andrew D Beggs, Benjamin E Willcox, Gary W Middleton.
Oncoimmunology, 2015 May 08; 4(3). PMID: 25949894    Free PMC article.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity.
Yunfei Zhang, Yong Zhang, +2 authors, Wen Luo.
PLoS One, 2015 May 12; 10(5). PMID: 25961716    Free PMC article.
Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma.
Saleh Rachidi, Kristin Wallace, +3 authors, Zihai Li.
Head Neck, 2015 Jun 05; 38 Suppl 1. PMID: 26040762    Free PMC article.
EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.
Laura Pisapia, Pasquale Barba, +3 authors, Giovanna Del Pozzo.
Int J Oncol, 2015 Jun 18; 47(2). PMID: 26081906    Free PMC article.
Rapid generation of NY-ESO-1-specific CD4+ THELPER1 cells for adoptive T-cell therapy.
Simone Kayser, Cristina Boβ, +11 authors, Tobias Feuchtinger.
Oncoimmunology, 2015 Jul 15; 4(5). PMID: 26155389    Free PMC article.
Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine.
Jeanne Galaine, Christophe Borg, Yann Godet, Olivier Adotévi.
Vaccines (Basel), 2015 Sep 10; 3(3). PMID: 26350591    Free PMC article.
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Kyle A Wilson, Stephen R Goding, +2 authors, Paul Andrew Antony.
Oncoimmunology, 2015 Sep 26; 4(8). PMID: 26405570    Free PMC article.
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Junko Matsuzaki, Takemasa Tsuji, +7 authors, Kunle Odunsi.
Sci Rep, 2015 Oct 09; 5. PMID: 26447332    Free PMC article.
New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies.
Thomas M Schmitt, Ingunn M Stromnes, Aude G Chapuis, Philip D Greenberg.
Clin Cancer Res, 2015 Oct 16; 21(23). PMID: 26463711    Free PMC article.
Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.
Jianbin Wang, Joshua J DeClercq, +5 authors, Michael C Holmes.
Nucleic Acids Res, 2015 Nov 04; 44(3). PMID: 26527725    Free PMC article.
T-cell receptor gene therapy--ready to go viral?
Terhi Karpanen, Johanna Olweus.
Mol Oncol, 2015 Nov 10; 9(10). PMID: 26548533    Free PMC article.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.
Payal Mittal, Marie-Clare St Rose, +4 authors, Adam J Adler.
J Immunol, 2015 Nov 13; 195(12). PMID: 26561553    Free PMC article.
Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut.
Yunji Park, Sook-Jin Moon, Seung-Woo Lee.
BMB Rep, 2015 Nov 26; 49(1). PMID: 26592937    Free PMC article.
Identification of Melanoma-reactive CD4+ T-Cell Subsets From Human Melanoma Draining Lymph Nodes.
Mei Zhang, Hallie Graor, Lu Yan, Julian Kim.
J Immunother, 2015 Dec 08; 39(1). PMID: 26641258    Free PMC article.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
Arata Takeuchi, Mohamed El Sherif Gadelhaq Badr, +11 authors, Takashi Saito.
J Exp Med, 2015 Dec 24; 213(1). PMID: 26694968    Free PMC article.
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.
Nicole Malandro, Sadna Budhu, +9 authors, Jedd D Wolchok.
Immunity, 2016 Jan 21; 44(1). PMID: 26789923    Free PMC article.
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic.
Kinga Majchrzak, Michelle H Nelson, +5 authors, Chrystal M Paulos.
Cancer Immunol Immunother, 2016 Jan 31; 65(3). PMID: 26825102    Free PMC article.
Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen.
Elena Shklovskaya, Alexandra M Terry, +5 authors, Barbara Fazekas de St. Groth.
Immunol Cell Biol, 2016 Feb 04; 94(6). PMID: 26837456
A role for pre-mNK cells in tumor progression.
Carolyn Rosinsky, Paul Andrew Antony.
J Immunother Cancer, 2016 Mar 17; 4. PMID: 26981246    Free PMC article.
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Meng-Lei Zhu, Pearl Bakhru, +6 authors, Maureen A Su.
Nat Commun, 2016 Apr 14; 7. PMID: 27072778    Free PMC article.
Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity.
Thomas V Guy, Alexandra M Terry, +6 authors, Barbara Fazekas de St. Groth.
Oncotarget, 2016 Apr 29; 7(21). PMID: 27121060    Free PMC article.
Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma.
Hongwei Xue, Fuhuang Lin, +3 authors, Ludong Zhao.
PLoS One, 2016 May 03; 11(5). PMID: 27136203    Free PMC article.
Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy.
Xin Yao, Yong-Chen Lu, +8 authors, Paul F Robbins.
J Immunother, 2016 May 11; 39(5). PMID: 27163739    Free PMC article.
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.
Masatoshi Hirayama, Yusuke Tomita, +16 authors, Yasuharu Nishimura.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471607    Free PMC article.
IL-7 signaling imparts polyfunctionality and stemness potential to CD4(+) T cells.
Zhi-Chun Ding, Chufeng Liu, +10 authors, Gang Zhou.
Oncoimmunology, 2016 Jul 30; 5(6). PMID: 27471650    Free PMC article.
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display.
Anders Tveita, Marte Fauskanger, Bjarne Bogen, Ole Audun Werner Haabeth.
Oncotarget, 2016 Sep 15; 7(41). PMID: 27626487    Free PMC article.
CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade.
Hongxia Yan, Xianglian Hou, +4 authors, Ruijie Zhu.
Tumour Biol, 2016 Oct 07;. PMID: 27709550
Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients.
Maggie L Diller, Ragini R Kudchadkar, +2 authors, Mandy L Ford.
J Immunother, 2016 Oct 16; 39(9). PMID: 27741090    Free PMC article.
Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.
Adam J Adler, Payal Mittal, +3 authors, Anthony T Vella.
Immunotherapy, 2016 Dec 22; 9(1). PMID: 28000531    Free PMC article.
The distribution and function of human memory T cell subsets in lung cancer.
Si Yuan Sheng, Yong Gu, +3 authors, RongFu Wang.
Immunol Res, 2017 Jan 20; 65(3). PMID: 28101811    Free PMC article.
Systemic Immunity Is Required for Effective Cancer Immunotherapy.
Matthew H Spitzer, Yaron Carmi, +10 authors, Edgar G Engleman.
Cell, 2017 Jan 24; 168(3). PMID: 28111070    Free PMC article.
Highly Cited.
CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies.
Nobutaka Hanagata.
Int J Nanomedicine, 2017 Feb 02; 12. PMID: 28144136    Free PMC article.
Fine-tuning the CAR spacer improves T-cell potency.
Norihiro Watanabe, Pradip Bajgain, +6 authors, Juan F Vera.
Oncoimmunology, 2017 Feb 10; 5(12). PMID: 28180032    Free PMC article.
Highly Cited.
Combination immunotherapy: a road map.
Patrick A Ott, F Stephen Hodi, +2 authors, Jedd D Wolchok.
J Immunother Cancer, 2017 Feb 28; 5. PMID: 28239469    Free PMC article.
Highly Cited. Review.
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function.
Arata Takeuchi, Takashi Saito.
Front Immunol, 2017 Mar 11; 8. PMID: 28280496    Free PMC article.
Highly Cited. Review.
Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis.
Daniel J Neitzke, Jacob S Bowers, +7 authors, Mark P Rubinstein.
Cancer Immunol Immunother, 2017 Mar 11; 66(6). PMID: 28280853    Free PMC article.
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
Jacob S Bowers, Michelle H Nelson, +6 authors, Chrystal M Paulos.
JCI Insight, 2017 Mar 16; 2(5). PMID: 28289713    Free PMC article.
Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system.
Krishna Das, David Eisel, +5 authors, Stefan B Eichmüller.
PLoS One, 2017 Mar 17; 12(3). PMID: 28301575    Free PMC article.
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response.
Kun He, Ping Liu, Lisa X Xu.
Cell Death Dis, 2017 Mar 24; 8(3). PMID: 28333145    Free PMC article.
HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance.
Barbara Seliger, Matthias Kloor, Soldano Ferrone.
Oncoimmunology, 2017 Mar 28; 6(2). PMID: 28344859    Free PMC article.
β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity.
Kinga Majchrzak, Michelle H Nelson, +9 authors, Chrystal M Paulos.
JCI Insight, 2017 Apr 20; 2(8). PMID: 28422756    Free PMC article.
B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment.
Giulia Chiaruttini, Silvia Mele, +4 authors, Sophia N Karagiannis.
Oncoimmunology, 2017 May 17; 6(4). PMID: 28507802    Free PMC article.
Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells.
Caroline Boudousquie, Giovanna Bossi, +3 authors, Namir J Hassan.
Immunology, 2017 Jun 24; 152(3). PMID: 28640942    Free PMC article.
Resident memory T cells in the skin mediate durable immunity to melanoma.
Brian T Malik, Katelyn T Byrne, +9 authors, Mary Jo Turk.
Sci Immunol, 2017 Jul 25; 2(10). PMID: 28738020    Free PMC article.
Highly Cited.
Vaccines targeting helper T cells for cancer immunotherapy.
Marit Melssen, Craig L Slingluff.
Curr Opin Immunol, 2017 Jul 30; 47. PMID: 28755541    Free PMC article.
Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.
Yong-Chen Lu, Linda L Parker, +14 authors, Steven A Rosenberg.
J Clin Oncol, 2017 Aug 16; 35(29). PMID: 28809608    Free PMC article.
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Expression of the MHC class II in triple-negative breast cancer is associated with tumor-infiltrating lymphocytes and interferon signaling.
In Ah Park, Seong-Hye Hwang, +7 authors, Hee Jin Lee.
PLoS One, 2017 Aug 18; 12(8). PMID: 28817603    Free PMC article.
The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade.
Howard Y Li, Maria McSharry, +8 authors, Raphael A Nemenoff.
Cancer Immunol Res, 2017 Aug 19; 5(9). PMID: 28819064    Free PMC article.
Most Do, but Some Do Not: CD4⁺CD25- T Cells, but Not CD4⁺CD25⁺ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR).
Andreas A Hombach, Hinrich Abken.
Cancers (Basel), 2017 Aug 30; 9(9). PMID: 28850063    Free PMC article.
Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells.
Tomohiro Tanaka, Satoshi Watanabe, +20 authors, Toshiaki Kikuchi.
PLoS One, 2017 Aug 31; 12(8). PMID: 28854279    Free PMC article.
Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.
David J Messenheimer, Shawn M Jensen, +6 authors, Bernard A Fox.
Clin Cancer Res, 2017 Sep 01; 23(20). PMID: 28855348    Free PMC article.
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Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells.
Zhi-Chun Ding, Tsadik Habtetsion, +8 authors, Gang Zhou.
Sci Rep, 2017 Sep 25; 7(1). PMID: 28939858    Free PMC article.
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.
Andrea J Manrique-Rincón, Camila M Beraldo, Jessica M Toscaro, Marcio C Bajgelman.
Front Immunol, 2017 Oct 05; 8. PMID: 28974950    Free PMC article.
CD4 and CD8 T lymphocyte interplay in controlling tumor growth.
Dmitrij Ostroumov, Nora Fekete-Drimusz, +2 authors, Norman Woller.
Cell Mol Life Sci, 2017 Oct 17; 75(4). PMID: 29032503    Free PMC article.
Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions.
Hsiu-Chuan Wei, Jui-Ling Yu, Chia-Yu Hsu.
Comput Math Methods Med, 2017 Dec 19; 2017. PMID: 29250133    Free PMC article.
An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.
Payal Mittal, Rebecca Abblett, +8 authors, Adam J Adler.
J Immunol, 2018 Jan 07; 200(4). PMID: 29305435    Free PMC article.
Citrullinated α-enolase is an effective target for anti-cancer immunity.
Katherine Cook, Ian Daniels, +6 authors, Victoria Brentville.
Oncoimmunology, 2018 Jan 09; 7(2). PMID: 29308319    Free PMC article.
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses.
Il-Kyu Choi, Zhe Wang, +10 authors, Baochun Zhang.
Proc Natl Acad Sci U S A, 2018 Jan 10; 115(4). PMID: 29311309    Free PMC article.
Significance of tumor-infiltrating lymphocytes before and after neoadjuvant therapy for rectal cancer.
Shinji Matsutani, Masatsune Shibutani, +5 authors, Masaichi Ohira.
Cancer Sci, 2018 Feb 22; 109(4). PMID: 29464828    Free PMC article.
17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.
Sandeep S Joshi, Shunlin Jiang, +4 authors, Thomas J Hornyak.
PLoS One, 2018 Feb 27; 13(2). PMID: 29481571    Free PMC article.
The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes.
Yasmina Serroukh, Chunyan Gu-Trantien, +15 authors, Arnaud Marchant.
Elife, 2018 Mar 01; 7. PMID: 29488879    Free PMC article.
Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling.
Masafumi Taniwaki, Mihoko Yoshida, +3 authors, Hiroto Kaneko.
Mediterr J Hematol Infect Dis, 2018 Mar 14; 10(1). PMID: 29531651    Free PMC article.
When worlds collide: Th17 and Treg cells in cancer and autoimmunity.
Hannah M Knochelmann, Connor J Dwyer, +4 authors, Chrystal M Paulos.
Cell Mol Immunol, 2018 Mar 23; 15(5). PMID: 29563615    Free PMC article.
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Verification of the methodology for evaluating tumor-infiltrating lymphocytes in colorectal cancer.
Shinji Matsutani, Masatsune Shibutani, +5 authors, Masaichi Ohira.
Oncotarget, 2018 Apr 11; 9(20). PMID: 29632635    Free PMC article.
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity.
Dongrui Wang, Brenda Aguilar, +6 authors, Christine E Brown.
JCI Insight, 2018 May 18; 3(10). PMID: 29769444    Free PMC article.
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Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.
T N Sharapova, E A Romanova, L P Sashchenko, D V Yashin.
J Immunol Res, 2018 Jun 01; 2018. PMID: 29850628    Free PMC article.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial.
Poulam M Patel, Christian H Ottensmeier, +15 authors, Lindy G Durrant.
Oncoimmunology, 2018 Jun 07; 7(6). PMID: 29872563    Free PMC article.
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Hannah M Knochelmann, Aubrey S Smith, +3 authors, Chrystal M Paulos.
Front Immunol, 2018 Aug 25; 9. PMID: 30140266    Free PMC article.
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The Paradoxical Role of NKG2D in Cancer Immunity.
Sam Sheppard, Amir Ferry, Joana Guedes, Nadia Guerra.
Front Immunol, 2018 Aug 29; 9. PMID: 30150983    Free PMC article.
Synaptic Interactions in Germinal Centers.
Ilenia Papa, Carola G Vinuesa.
Front Immunol, 2018 Aug 29; 9. PMID: 30150988    Free PMC article.
The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity.
Claudia Afferni, Carla Buccione, +5 authors, Giovanna Schiavoni.
Front Immunol, 2018 Nov 30; 9. PMID: 30483263    Free PMC article.
Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.
Anna E Oja, Berber Piet, +8 authors, Pleun Hombrink.
Front Immunol, 2018 Dec 07; 9. PMID: 30505306    Free PMC article.
A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity.
Diana Rasoulouniriana, Nadine Santana-Magal, +11 authors, Yaron Carmi.
J Clin Invest, 2019 Aug 27; 129(10). PMID: 31449054    Free PMC article.
T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity.
Preeti Sharma, Daniel T Harris, Jennifer D Stone, David M Kranz.
Cancer Immunol Res, 2019 Sep 25; 7(12). PMID: 31548259    Free PMC article.
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control.
Elena Tondini, Tsolere Arakelian, +7 authors, Ferry Ossendorp.
Oncoimmunology, 2019 Oct 28; 8(11). PMID: 31646082    Free PMC article.
The ST2/Interleukin-33 Axis in Hematologic Malignancies: The IL-33 Paradox.
Alessandro Allegra, Vanessa Innao, +4 authors, Sebastiano Gangemi.
Int J Mol Sci, 2019 Oct 28; 20(20). PMID: 31652497    Free PMC article.
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
Kosuke Hashimoto, Tsukasa Kouno, +17 authors, Piero Carninci.
Proc Natl Acad Sci U S A, 2019 Nov 14; 116(48). PMID: 31719197    Free PMC article.
The Ancient Chinese Decoction Yu-Ping-Feng Suppresses Orthotopic Lewis Lung Cancer Tumor Growth Through Increasing M1 Macrophage Polarization and CD4+ T Cell Cytotoxicity.
Lixin Wang, Wenbin Wu, +7 authors, Shiguo Zhu.
Front Pharmacol, 2019 Nov 30; 10. PMID: 31780946    Free PMC article.
Biological Consequences of MHC-II Expression by Tumor Cells in Cancer.
Margaret L Axelrod, Rebecca S Cook, Douglas B Johnson, Justin M Balko.
Clin Cancer Res, 2018 Nov 23; 25(8). PMID: 30463850    Free PMC article.
Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy.
Pavlina Chuntova, Kira M Downey, +2 authors, Hideho Okada.
Front Immunol, 2019 Feb 12; 9. PMID: 30740109    Free PMC article.
Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism.
Crystal Morales Del Valle, Joseph R Maxwell, +5 authors, Anthony T Vella.
Cell Rep, 2019 May 03; 27(5). PMID: 31042471    Free PMC article.
Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.
Nithya Sivaram, Patrick A McLaughlin, +7 authors, Richard Z Lin.
J Clin Invest, 2019 May 22; 129(8). PMID: 31112530    Free PMC article.
IL22 drives cutaneous melanoma cell proliferation, migration and invasion through activation of miR-181/STAT3/AKT axis.
Yuanmin He, Yan Yang, +4 authors, Xia Xiong.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201538    Free PMC article.
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation.
Teresa Preglej, Patricia Hamminger, +22 authors, Wilfried Ellmeier.
JCI Insight, 2020 Feb 28; 5(4). PMID: 32102981    Free PMC article.
Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype.
David Eisel, Krishna Das, +3 authors, Stefan B Eichmüller.
Front Immunol, 2019 Mar 12; 10. PMID: 30853959    Free PMC article.
Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells.
Marjolein Schluck, Roel Hammink, +2 authors, Jorieke Weiden.
Front Immunol, 2019 May 28; 10. PMID: 31130945    Free PMC article.
Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help.
Eleni Maria Varypataki, Fabio Hasler, +6 authors, Pål Johansen.
Front Immunol, 2019 Jul 25; 10. PMID: 31333674    Free PMC article.
Long-term surviving cancer patients as a source of therapeutic TCR.
Else Marit Inderberg, Sébastien Wälchli.
Cancer Immunol Immunother, 2020 Jan 10; 69(5). PMID: 31915853    Free PMC article.
From Superantigens to "Real" Viral Antigens.
Marcia A Blackman.
Viral Immunol, 2020 Apr 15; 33(3). PMID: 32286177    Free PMC article.
Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses.
Victoria A Brentville, Rachael L Metheringham, +11 authors, Lindy G Durrant.
J Immunother Cancer, 2020 Jun 21; 8(1). PMID: 32561639    Free PMC article.
GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen.
Matthew P Rausch, Lydia R Meador, +4 authors, K Taraszka Hastings.
J Immunol, 2020 Apr 10; 204(11). PMID: 32269095    Free PMC article.
Telomerase and CD4 T Cell Immunity in Cancer.
Magalie Dosset, Andrea Castro, Hannah Carter, Maurizio Zanetti.
Cancers (Basel), 2020 Jul 08; 12(6). PMID: 32630460    Free PMC article.
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Anna Śledzińska, Maria Vila de Mucha, +19 authors, Sergio A Quezada.
Immunity, 2020 Jan 12; 52(1). PMID: 31924474    Free PMC article.
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy.
Lukas Amon, Lukas Hatscher, +2 authors, Christian H K Lehmann.
Pharmaceutics, 2020 Jul 18; 12(7). PMID: 32674488    Free PMC article.
The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.
Joji Nagasaki, Yosuke Togashi, +10 authors, Hiroyoshi Nishikawa.
Blood Adv, 2020 Sep 02; 4(17). PMID: 32870971    Free PMC article.
CD4+ T Cell Help Selectively Enhances High-Avidity Tumor Antigen-Specific CD8+ T Cells.
Ziqiang Zhu, Steven M Cuss, +5 authors, Arthur A Hurwitz.
J Immunol, 2015 Sep 01; 195(7). PMID: 26320256    Free PMC article.
Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.
L Zhang, Z Yu, +4 authors, R A Morgan.
Gene Ther, 2012 Sep 14; 20(5). PMID: 22972494    Free PMC article.
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Eric Tran, Simon Turcotte, +10 authors, Steven A Rosenberg.
Science, 2014 May 09; 344(6184). PMID: 24812403    Free PMC article.
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IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity.
Hidekazu Shirota, Dennis M Klinman, +3 authors, Chikashi Ishioka.
Cancer Immunol Res, 2016 Dec 07; 5(1). PMID: 27920023    Free PMC article.
Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer.
Sarah I Davies, John Barrett, +3 authors, Isaac Brownell.
Front Immunol, 2020 Dec 29; 11. PMID: 33362774    Free PMC article.
Harnessing neoantigen specific CD4 T cells for cancer immunotherapy.
Spencer E Brightman, Martin S Naradikian, Aaron M Miller, Stephen P Schoenberger.
J Leukoc Biol, 2020 Mar 15; 107(4). PMID: 32170883    Free PMC article.
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.
Yashwanth Subbannayya, Markus Haug, +5 authors, Richard K Kandasamy.
Int J Mol Sci, 2021 Jan 02; 22(1). PMID: 33383959    Free PMC article.
CD4+ T cell exhaustion leads to adoptive transfer therapy failure which can be prevented by immune checkpoint blockade.
Jinfei Fu, Anze Yu, +4 authors, Bin He.
Am J Cancer Res, 2021 Jan 09; 10(12). PMID: 33414997    Free PMC article.
CD4 Inhibits Helper T Cell Activation at Lower Affinity Threshold for Full-Length T Cell Receptors Than Single Chain Signaling Constructs.
Deborah K Johnson, Wyatt Magoffin, +6 authors, K Scott Weber.
Front Immunol, 2021 Feb 06; 11. PMID: 33542711    Free PMC article.
Revisiting the role of CD4+ T cells in cancer immunotherapy-new insights into old paradigms.
Rong En Tay, Emma K Richardson, Han Chong Toh.
Cancer Gene Ther, 2020 May 28; 28(1-2). PMID: 32457487    Free PMC article.
Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms.
Jianyu Chen, Honghao Zhang, +4 authors, Yuhua Li.
Front Oncol, 2021 Feb 23; 10. PMID: 33614478    Free PMC article.
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Amélie Cachot, Mariia Bilous, +22 authors, Camilla Jandus.
Sci Adv, 2021 Feb 28; 7(9). PMID: 33637530    Free PMC article.
Default polyfunctional T helper 1 response to ample signal 1 alone.
Luca Danelli, Georgina Cornish, Julia Merkenschlager, George Kassiotis.
Cell Mol Immunol, 2020 Apr 22; 18(7). PMID: 32313208    Free PMC article.
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer.
Margaux Saillard, Mara Cenerenti, Pedro Romero, Camilla Jandus.
Vaccines (Basel), 2021 Jun 03; 9(5). PMID: 34064410    Free PMC article.
Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity.
Zhi-Chun Ding, Huidong Shi, +11 authors, Gang Zhou.
Sci Immunol, 2020 Nov 01; 5(52). PMID: 33127608    Free PMC article.
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
Elena Shklovskaya, Helen Rizos.
Int J Mol Sci, 2021 Jul 03; 22(13). PMID: 34201655    Free PMC article.
Epigenetic Reprogramming of CD4+ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.
Elodie Renaude, Marie Kroemer, +4 authors, Olivier Adotévi.
Front Immunol, 2021 Jul 16; 12. PMID: 34262562    Free PMC article.
Double-edged effects of interferons on the regulation of cancer-immunity cycle.
Xiao Zhang, Song Wang, +5 authors, Xiaobo Li.
Oncoimmunology, 2021 Jul 16; 10(1). PMID: 34262796    Free PMC article.
Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines.
Alexander J Stephens, Nicola A Burgess-Brown, Shisong Jiang.
Front Immunol, 2021 Jul 20; 12. PMID: 34276688    Free PMC article.
Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation.
Cory J Knudson, Maria Férez, +5 authors, Luis J Sigal.
J Virol, 2021 Jul 15; 95(19). PMID: 34260270    Free PMC article.
Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4+ T Cells in the Central Region of pMMR CRC.
Jingwen Qi, Xiaoyan Liu, +14 authors, Wei Yang.
Front Oncol, 2021 Oct 12; 11. PMID: 34631551    Free PMC article.
Immunity beyond cancer cells: perspective from tumor tissue.
Shengyu Gao, Ting-Wei Hsu, Ming O Li.
Trends Cancer, 2021 Jul 27; 7(11). PMID: 34305041    Free PMC article.
Supplementation with Serum-Derived Extracellular Vesicles Reinforces Antitumor Immunity Induced by Cryo-Thermal Therapy.
Yinuo Cen, Yue Lou, +4 authors, Ping Liu.
Int J Mol Sci, 2021 Oct 24; 22(20). PMID: 34681680    Free PMC article.
CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?
Alexandra M Miggelbrink, Joshua D Jackson, +4 authors, Peter E Fecci.
Clin Cancer Res, 2021 Jun 16; 27(21). PMID: 34127507    Free PMC article.
Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.
Eva-Maria Surmann, Anita Y Voigt, +5 authors, Matthias Kloor.
Cancer Immunol Immunother, 2014 Dec 03; 64(3). PMID: 25445815    Free PMC article.
Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.
Semir Beyaz, Charlie Chung, +30 authors, Ömer H Yilmaz.
Cell Stem Cell, 2021 Sep 17; 28(11). PMID: 34529935    Free PMC article.
Factors Determining Long-Term Antitumor Responses to Immune Checkpoint Blockade Therapy in Melanoma.
Kimberly Loo, James W Smithy, Michael A Postow, Allison Betof Warner.
Front Immunol, 2022 Jan 29; 12. PMID: 35087529    Free PMC article.
Identification of neoantigens for individualized therapeutic cancer vaccines.
Franziska Lang, Barbara Schrörs, +2 authors, Ugur Sahin.
Nat Rev Drug Discov, 2022 Feb 03; 21(4). PMID: 35105974    Free PMC article.
Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox.
David Y Oh, Lawrence Fong.
Immunity, 2021 Dec 16; 54(12). PMID: 34910940    Free PMC article.
A T-cell independent universal cellular therapy strategy through antigen depletion.
Dan Li, Wenbing Wang, +6 authors, Han Liu.
Theranostics, 2022 Feb 15; 12(3). PMID: 35154479    Free PMC article.
Epigenetics of Dendritic Cells in Tumor Immunology.
Gerard Godoy-Tena, Esteban Ballestar.
Cancers (Basel), 2022 Mar 11; 14(5). PMID: 35267487    Free PMC article.
Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens.
Selma Bekri, Reunet Rodney-Sandy, +5 authors, Hearn Jay Cho.
J Immunother Cancer, 2022 Feb 23; 10(2). PMID: 35190376    Free PMC article.
Messenger RNA vaccines for cancer immunotherapy: progress promotes promise.
Amanda L Huff, Elizabeth M Jaffee, Neeha Zaidi.
J Clin Invest, 2022 Mar 16; 132(6). PMID: 35289317    Free PMC article.
High-throughput single-сell sequencing in cancer research.
Qingzhu Jia, Han Chu, +2 authors, Bo Zhu.
Signal Transduct Target Ther, 2022 May 04; 7(1). PMID: 35504878    Free PMC article.
Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination.
Rodrigo Nalio Ramos, Caroline Tosch, +20 authors, Karola Rittner.
Clin Transl Immunology, 2022 May 17; 11(5). PMID: 35573979    Free PMC article.