Journal Article
. 1991 Jul;15(4).
doi: 10.1097/00004728-199107000-00018.

Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging

G Brix 1 W Semmler  R Port  L R Schad  G Layer  W J Lorenz  
  • PMID: 2061479
  •     139 citations


Dynamic MR imaging can be used to study tissue perfusion and vascular permeability. In the present article a procedure for dynamic MR is presented, which (a) accurately resolves the fast kinetics of tissue response during and after intravenous infusion of the paramagnetic contrast medium Gd-DTPA and (b) yields a linear relationship between the measured MR signal and the Gd-DTPA concentration in the tissue. According to these features, the measured signal-time curves can be analyzed within the framework of pharmacokinetic modeling. Tissue response has been parameterized using a linear two-compartment open model, with only negligible effects of the peripheral compartment on the central compartment. The three model parameters were fitted to the signal-time data pixel by pixel, based on a set of 64 rapid SE images (SE 100/10 ms, image scan time 13 s, interscan intervals 11 s). This makes it possible to construct parameter images, whereby structures become visible that cannot be distinguished in conventional Gd-DTPA enhanced MR. As a clinical example, the approach is discussed in a case of glioblastoma.

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Curr Rheumatol Rep, 2017 Jul 19; 19(8). PMID: 28718064
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J Transl Med, 2017 Dec 05; 15(1). PMID: 29197390    Free PMC article.
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J Magn Reson Imaging, 2018 May 08; 48(5). PMID: 29734499    Free PMC article.
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Application of Distributed Parameter Model to Assessment of Glioma IDH Mutation Status by Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
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