Journal Article
. 1991 Jul;15(4).
doi: 10.1097/00004728-199107000-00018.

Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging

G Brix 1 W Semmler  R Port  L R Schad  G Layer  W J Lorenz  
Affiliations
  • PMID: 2061479
  •     139 citations

Abstract

Dynamic MR imaging can be used to study tissue perfusion and vascular permeability. In the present article a procedure for dynamic MR is presented, which (a) accurately resolves the fast kinetics of tissue response during and after intravenous infusion of the paramagnetic contrast medium Gd-DTPA and (b) yields a linear relationship between the measured MR signal and the Gd-DTPA concentration in the tissue. According to these features, the measured signal-time curves can be analyzed within the framework of pharmacokinetic modeling. Tissue response has been parameterized using a linear two-compartment open model, with only negligible effects of the peripheral compartment on the central compartment. The three model parameters were fitted to the signal-time data pixel by pixel, based on a set of 64 rapid SE images (SE 100/10 ms, image scan time 13 s, interscan intervals 11 s). This makes it possible to construct parameter images, whereby structures become visible that cannot be distinguished in conventional Gd-DTPA enhanced MR. As a clinical example, the approach is discussed in a case of glioblastoma.

The demonstration of glomus tumours by subtraction MRI.
G A Lloyd, A D Cheesman, P D Phelps, C M King.
Neuroradiology, 1992 Jan 01; 34(6). PMID: 1331855
Dynamic contrast-enhanced magnetic resonance imaging reveals stress-induced angiogenesis in MCF7 human breast tumors.
E Furman-Haran, R Margalit, D Grobgeld, H Degani.
Proc Natl Acad Sci U S A, 1996 Jun 25; 93(13). PMID: 8692800    Free PMC article.
Cervical carcinoma: standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival.
H Hawighorst, P G Knapstein, +2 authors, G van Kaick.
MAGMA, 1999 Jun 26; 8(1). PMID: 10383094
Quantitative imaging of tumour blood flow by contrast-enhanced magnetic resonance imaging.
S Pahernik, J Griebel, +4 authors, A E Goetz.
Br J Cancer, 2001 Dec 18; 85(11). PMID: 11742483    Free PMC article.
Noninvasive methods to study drug distribution.
Ruediger E Port, Walter Wolf.
Invest New Drugs, 2003 Aug 02; 21(2). PMID: 12889737
Review.
Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens?
Heinz-Peter Schlemmer, Jonas Merkle, +5 authors, Gerhard van Kaick.
Eur Radiol, 2003 Oct 08; 14(2). PMID: 14531000
[Dynamic magnetic resonance tomography (dMRT). It's value in advanced head-neck tumors treated with radiochemotherapy].
M Helbig, H-P Schlemmer, +2 authors, A Dietz.
HNO, 2003 Nov 08; 51(11). PMID: 14605706
Dynamic contrast-enhanced magnetic resonance imaging rapidly indicates vessel regression in human squamous cell carcinomas grown in nude mice caused by VEGF receptor 2 blockade with DC101.
Fabian Kiessling, Nabeel Farhan, +9 authors, Stefan Delorme.
Neoplasia, 2004 May 22; 6(3). PMID: 15153333    Free PMC article.
Benign prostate hyperplasia: evaluation of treatment response with DCE MRI.
J T Heverhagen, H von Tengg-Kobligk, +6 authors, M V Knopp.
MAGMA, 2004 Jun 29; 17(1). PMID: 15221660
Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRI.
Fabian Kiessling, Matthias Lichy, +9 authors, Stefan Delorme.
Eur Radiol, 2004 Jul 03; 14(10). PMID: 15232714
The relationship between vascular and metabolic characteristics of primary breast tumours.
Scott I K Semple, Fiona J Gilbert, +7 authors, Shailesh Chaturvedi.
Eur Radiol, 2004 Aug 19; 14(11). PMID: 15316743
Dynamic contrast-enhanced MRI using macromolecular contrast media for monitoring the response to isolated limb perfusion in experimental soft-tissue sarcomas.
A Preda, P A Wielopolski, +8 authors, C F van Dijke.
MAGMA, 2004 Oct 14; 17(3-6). PMID: 15480945
MR perfusion measurements on pharyngeal tumors: comparison of quantification strategies.
Volker Hietschold, Thomas Kittner, +3 authors, Michael Laniado.
J Appl Clin Med Phys, 2005 Mar 02; 5(4). PMID: 15738924    Free PMC article.
Spatiotemporal Hopfield neural cube for diagnosing recurrent nasal papilloma.
C Y Chang.
Med Biol Eng Comput, 2005 Mar 04; 43(1). PMID: 15742715
Improved correlation of histological data with DCE MRI parameter maps by 3D reconstruction, reslicing and parameterization of the histological images.
Fabian Kiessling, Martin Le-Huu, +7 authors, Wolfhard Semmler.
Eur Radiol, 2005 Mar 05; 15(6). PMID: 15747142
Pharmacokinetic analysis of ductal carcinoma in situ of the breast using dynamic MR mammography.
Keiko Oshida, Takeshi Nagashima, +7 authors, Masaru Miyazaki.
Eur Radiol, 2005 Mar 25; 15(7). PMID: 15789211
The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.
M O Leach, K M Brindle, +19 authors, Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK.
Br J Cancer, 2005 May 05; 92(9). PMID: 15870830    Free PMC article.
Highly Cited.
Magnetic resonance characterization of tumor microvessels in experimental breast tumors using a slow clearance blood pool contrast agent (carboxymethyldextran-A2-Gd-DOTA) with histopathological correlation.
Anda Preda, Viktor Novikov, +7 authors, Robert C Brasch.
Eur Radiol, 2005 Jul 14; 15(11). PMID: 16012822
[Innovative concepts in early cancer detection and staging of localized prostate cancer].
L Rinnab, R Küfer, +4 authors, H W Gottfried.
Urologe A, 2005 Oct 26; 44(11). PMID: 16247635
Review.
Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
Xiaobing Fan, Milica Medved, +6 authors, Philippe Bourrinet.
MAGMA, 2006 Jan 18; 19(1). PMID: 16416323
Non-invasive assessment of vessel morphology and function in tumors by magnetic resonance imaging.
Fabian Kiessling, Manfred Jugold, Eva C Woenne, Gunnar Brix.
Eur Radiol, 2007 Feb 20; 17(8). PMID: 17308924
Review.
Diagnosis of suspicious breast lesions using an empirical mathematical model for dynamic contrast-enhanced MRI.
Xiaobing Fan, Milica Medved, +7 authors, Gillian M Newstead.
Magn Reson Imaging, 2007 Jun 02; 25(5). PMID: 17540270    Free PMC article.
Mechanism of action of octreotide in acromegalic tumours in vivo using dynamic contrast-enhanced magnetic resonance imaging.
Thozhukat Sathyapalan, Martin Lowry, +2 authors, Stephen L Atkin.
Pituitary, 2007 Jun 02; 10(3). PMID: 17541750
Effect of dopamine agonists on prolactinomas and normal pituitary assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).
Alireza M Manuchehri, Thozhukat Sathyapalan, +3 authors, Stephen L Atkin.
Pituitary, 2007 Jun 09; 10(3). PMID: 17557207
Value of magnetic resonance imaging in prostate cancer diagnosis.
Friedrich Aigner, Leo Pallwein, +4 authors, Ferdinand Frauscher.
World J Urol, 2007 Jun 15; 25(4). PMID: 17569054
Review.
Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model.
Moira C Ferrier, Hemant Sarin, +7 authors, John A Butman.
Neoplasia, 2007 Aug 22; 9(7). PMID: 17710157    Free PMC article.
Bevacizumab inhibits breast cancer-induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI.
Tobias Bäuerle, Heidegard Hilbig, +6 authors, Martin R Berger.
Neoplasia, 2008 May 14; 10(5). PMID: 18472968    Free PMC article.
Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective.
Naranamangalam R Jagannathan, Virendra Kumar, Rajeev Kumar, Sanjay Thulkar.
MAGMA, 2008 Jul 18; 21(6). PMID: 18633658
Review.
Perfusion characteristics of late radiation injury of parotid glands: quantitative evaluation with dynamic contrast-enhanced MRI.
Chun-Jung Juan, Cheng-Yu Chen, +8 authors, Hsiao-Wen Chung.
Eur Radiol, 2008 Jul 29; 19(1). PMID: 18661135
[Modern magnetic resonance procedures for assessing tumor response].
T Persigehl, W Heindel, C Bremer.
Radiologe, 2008 Aug 13; 48(9). PMID: 18696035
Assessment of bone perfusion with contrast-enhanced magnetic resonance imaging.
Jonathan H Lee, Jonathan P Dyke, +3 authors, Roy K Aaron.
Orthop Clin North Am, 2009 Apr 11; 40(2). PMID: 19358910    Free PMC article.
Subchondral fluid dynamics in a model of osteoarthritis: use of dynamic contrast-enhanced magnetic resonance imaging.
J H Lee, J P Dyke, +3 authors, R K Aaron.
Osteoarthritis Cartilage, 2009 May 05; 17(10). PMID: 19409292    Free PMC article.
A vasculature-targeting regimen of preoperative docetaxel with or without bevacizumab for locally advanced breast cancer: impact on angiogenic biomarkers.
Joseph Baar, Paula Silverman, +15 authors, Beth Overmoyer.
Clin Cancer Res, 2009 May 07; 15(10). PMID: 19417018    Free PMC article.
Imaging response to systemic therapy for bone metastases.
Tobias Bäuerle, Wolfhard Semmler.
Eur Radiol, 2009 May 27; 19(10). PMID: 19468736
Review.
Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers.
Efstathios Karathanasis, Leslie Chan, +5 authors, Ravi V Bellamkonda.
PLoS One, 2009 Jun 11; 4(6). PMID: 19513111    Free PMC article.
Dynamic contrast-enhanced magnetic resonance imaging parameters independent of baseline T10 values.
Jun-Yu Guo, Wilburn E Reddick, Mark A Rosen, Hee Kwon Song.
Magn Reson Imaging, 2009 Jun 30; 27(9). PMID: 19559556    Free PMC article.
Pharmacokinetic analysis of tissue microcirculation using nested models: multimodel inference and parameter identifiability.
Gunnar Brix, Stefan Zwick, Fabian Kiessling, Jürgen Griebel.
Med Phys, 2009 Aug 14; 36(7). PMID: 19673191    Free PMC article.
Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI.
Stefan Zwick, Gunnar Brix, +5 authors, Fabian Kiessling.
Eur Radiol, 2009 Sep 04; 20(2). PMID: 19727758
Dynamic contrast-enhanced MR imaging to assess physiologic variations of myometrial perfusion.
Isabelle Thomassin-Naggara, Daniel Balvay, +3 authors, Marc Bazot.
Eur Radiol, 2009 Oct 13; 20(4). PMID: 19820949
Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples.
Thomas E Yankeelov, John C Gore.
Curr Med Imaging Rev, 2009 Oct 16; 3(2). PMID: 19829742    Free PMC article.
Highly Cited.
Principal component analysis of breast DCE-MRI adjusted with a model-based method.
Erez Eyal, Daria Badikhi, +3 authors, Hadassa Degani.
J Magn Reson Imaging, 2009 Oct 27; 30(5). PMID: 19856419    Free PMC article.
Multidisciplinary functional MR imaging for prostate cancer.
Jeong Kon Kim, Yun-Jin Jang, Gyunggoo Cho.
Korean J Radiol, 2009 Nov 04; 10(6). PMID: 19885309    Free PMC article.
Review.
Comparison of diagnostic quality and accuracy in color-coded versus gray-scale DCE-MR imaging display.
A Mehndiratta, M V Knopp, +6 authors, F L Giesel.
Int J Comput Assist Radiol Surg, 2009 Dec 25; 4(5). PMID: 20033528
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
Wiltrud Lederle, Nina Linde, +7 authors, Margareta M Mueller.
Am J Pathol, 2010 Jan 01; 176(2). PMID: 20042679    Free PMC article.
Changes in magnetic resonance bone marrow angiogenesis on day 7 after induction chemotherapy can predict outcome of acute myeloid leukemia.
Hsin-An Hou, Tiffany Ting-Fang Shih, +7 authors, Hwei-Fang Tien.
Haematologica, 2010 Mar 12; 95(8). PMID: 20220062    Free PMC article.
Perfusion in rat brain at 7 T with arterial spin labeling using FAIR-TrueFISP and QUIPSS.
Emilio Esparza-Coss, Jarek Wosik, Ponnada A Narayana.
Magn Reson Imaging, 2010 Mar 20; 28(4). PMID: 20299174    Free PMC article.
High-resolution magnetic resonance colonography and dynamic contrast-enhanced magnetic resonance imaging in a murine model of colitis.
Devkumar Mustafi, Xiaobing Fan, +6 authors, Marta Zamora.
Magn Reson Med, 2010 Apr 08; 63(4). PMID: 20373393    Free PMC article.
Tracer kinetic modelling of tumour angiogenesis based on dynamic contrast-enhanced CT and MRI measurements.
Gunnar Brix, Jürgen Griebel, Fabian Kiessling, Frederik Wenz.
Eur J Nucl Med Mol Imaging, 2010 May 27; 37 Suppl 1. PMID: 20503049
Review.
Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination.
Xin Li, William D Rooney, +8 authors, Charles S Springer.
J Magn Reson, 2010 Aug 03; 206(2). PMID: 20674422    Free PMC article.
Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer.
Oana I Craciunescu, Donald E Thrall, Zeljko Vujaskovic, Mark W Dewhirst.
Int J Hyperthermia, 2010 Sep 21; 26(7). PMID: 20849258    Free PMC article.
Review.
MRI for men undergoing active surveillance or with rising PSA and negative biopsies.
Orit Raz, Masoom Haider, +2 authors, Nathan Lawrentschuk.
Nat Rev Urol, 2010 Oct 12; 7(10). PMID: 20930867
Review.
Use of dynamic contrast-enhanced MRI to measure subtle blood-brain barrier abnormalities.
Paul A Armitage, Andrew J Farrall, +2 authors, Joanna M Wardlaw.
Magn Reson Imaging, 2010 Oct 30; 29(3). PMID: 21030178    Free PMC article.
An expectation-maximisation approach for simultaneous pixel classification and tracer kinetic modelling in dynamic contrast enhanced-magnetic resonance imaging.
Mario Sansone, Roberta Fusco, +2 authors, Marcello Bracale.
Med Biol Eng Comput, 2010 Nov 04; 49(4). PMID: 21046274
Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer.
Tobias Franiel, Bernd Hamm, Hedvig Hricak.
Eur Radiol, 2010 Dec 25; 21(3). PMID: 21184082
Review.
Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings.
Toru Chikui, Shintaro Kawano, +9 authors, Kazunori Yoshiura.
Eur Radiol, 2011 Mar 12; 21(8). PMID: 21394565
Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging.
Junichi Tokuda, Hatsuho Mamata, +6 authors, Hiroto Hatabu.
J Magn Reson Imaging, 2011 Mar 31; 33(4). PMID: 21448965    Free PMC article.
Quantifying tumor vascular heterogeneity with dynamic contrast-enhanced magnetic resonance imaging: a review.
Xiangyu Yang, Michael V Knopp.
J Biomed Biotechnol, 2011 May 05; 2011. PMID: 21541193    Free PMC article.
Review.
Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness.
J Yaligar, S B Thakur, +8 authors, J A Koutcher.
NMR Biomed, 2011 May 28; 25(1). PMID: 21618306    Free PMC article.
Current and future imaging modalities for multiple myeloma and its precursor states.
Esther Tan, Brendan M Weiss, +3 authors, Ola Landgren.
Leuk Lymphoma, 2011 Jun 09; 52(9). PMID: 21649546    Free PMC article.
Review.
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761.
Mengxian Zhang, Tobias W Herion, +7 authors, Peter E Huber.
Neoplasia, 2011 Jun 17; 13(6). PMID: 21677877    Free PMC article.
Quantitative evaluation of the tibial tunnel after anterior cruciate ligament reconstruction using diffusion weighted and dynamic contrast enhanced MRI: a follow-up feasibility study.
Mitja Rupreht, Vladimir Jevtič, +3 authors, Marko Jevšek.
Skeletal Radiol, 2011 Sep 01; 41(5). PMID: 21879337
Evaluation of antiangiogenic effects of a new synthetic candidate drug KR-31831 on xenografted ovarian carcinoma using dynamic contrast enhanced MRI.
Jehoon Yang, Jae-Hun Kim, +5 authors, Pyoung Jeon.
Korean J Radiol, 2011 Sep 20; 12(5). PMID: 21927562    Free PMC article.
Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts.
Eirik Hagtvet, Kathrine Røe, Dag R Olsen.
Radiat Oncol, 2011 Oct 11; 6. PMID: 21981945    Free PMC article.
Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study.
Isabelle Thomassin-Naggara, Daniel Balvay, +4 authors, Marc Bazot.
Eur Radiol, 2011 Nov 23; 22(4). PMID: 22105841
3-T dynamic contrast-enhanced MRI of the breast: pharmacokinetic parameters versus conventional kinetic curve analysis.
Riham H El Khouli, Katarzyna J Macura, +2 authors, David A Bluemke.
AJR Am J Roentgenol, 2011 Nov 24; 197(6). PMID: 22109308    Free PMC article.
Multi-modal imaging of angiogenesis in a nude rat model of breast cancer bone metastasis using magnetic resonance imaging, volumetric computed tomography and ultrasound.
Tobias Bäuerle, Dorde Komljenovic, Martin R Berger, Wolfhard Semmler.
J Vis Exp, 2012 Aug 30; (66). PMID: 22929330    Free PMC article.
Practical dynamic contrast enhanced MRI in small animal models of cancer: data acquisition, data analysis, and interpretation.
Stephanie L Barnes, Jennifer G Whisenant, Mary E Loveless, Thomas E Yankeelov.
Pharmaceutics, 2012 Oct 30; 4(3). PMID: 23105959    Free PMC article.
The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region.
Toru Chikui, Makoto Obara, +9 authors, Kazunori Yoshiura.
Int J Dent, 2012 Nov 03; 2012. PMID: 23118750    Free PMC article.
Parameter optimization for quantitative signal-concentration mapping using spoiled gradient echo MRI.
Gasser Hathout, Neema Jamshidi.
Radiol Res Pract, 2012 Dec 06; 2012. PMID: 23213523    Free PMC article.
A linear algorithm of the reference region model for DCE-MRI is robust and relaxes requirements for temporal resolution.
Julio Cárdenas-Rodríguez, Christine M Howison, Mark D Pagel.
Magn Reson Imaging, 2012 Dec 12; 31(4). PMID: 23228309    Free PMC article.
Perfusion MRI: the five most frequently asked technical questions.
Marco Essig, Mark S Shiroishi, +8 authors, Meng Law.
AJR Am J Roentgenol, 2012 Dec 21; 200(1). PMID: 23255738    Free PMC article.
Review.
Quantitative evaluation of dual-flip-angle T1 mapping on DCE-MRI kinetic parameter estimation in head and neck.
Jing Yuan, Steven Kwok Keung Chow, +2 authors, Ann D King.
Quant Imaging Med Surg, 2013 Jan 05; 2(4). PMID: 23289084    Free PMC article.
The use of dynamic tracer concentration in veins for quantitative DCE-MRI kinetic analysis in head and neck.
Jing Yuan, Steven Kwok Keung Chow, +3 authors, Ann D King.
PLoS One, 2013 Mar 26; 8(3). PMID: 23527281    Free PMC article.
Assessment of feasibility to use computer aided texture analysis based tool for parametric images of suspicious lesions in DCE-MR mammography.
Mehmet Cemil Kale, John David Fleig, Nazım Imal.
Comput Math Methods Med, 2013 May 09; 2013. PMID: 23653668    Free PMC article.
Dynamic MR imaging of osteoid osteomas: correlation of semiquantitative and quantitative perfusion parameters with patient symptoms and treatment outcome.
Pedro A Gondim Teixeira, Anne Chanson, +5 authors, Alain Blum.
Eur Radiol, 2013 May 23; 23(9). PMID: 23695220
Dynamic contrast-enhanced MRI for monitoring antiangiogenic treatment: determination of accurate and reliable perfusion parameters in a longitudinal study of a mouse xenograft model.
Youngkyu Song, Gyunggoo Cho, +4 authors, Jeong Kon Kim.
Korean J Radiol, 2013 Aug 01; 14(4). PMID: 23901316    Free PMC article.
A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics.
Shengping Qin, Brett Z Fite, +4 authors, Katherine W Ferrara.
Ann Biomed Eng, 2013 Sep 11; 42(2). PMID: 24018607    Free PMC article.
Review.
Automatic segmentation of invasive breast carcinomas from dynamic contrast-enhanced MRI using time series analysis.
Jagadaeesan Jayender, Sona Chikarmane, Ferenc A Jolesz, Eva Gombos.
J Magn Reson Imaging, 2013 Oct 12; 40(2). PMID: 24115175    Free PMC article.
DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data.
Juan E Ortuño, María J Ledesma-Carbayo, +3 authors, Andrés Santos.
BMC Bioinformatics, 2013 Nov 05; 14. PMID: 24180558    Free PMC article.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments.
Thomas Nielsen, Thomas Wittenborn, Michael R Horsman.
Pharmaceutics, 2012 Jan 01; 4(4). PMID: 24300371    Free PMC article.
Quantitative serial MRI of the treated fibroid uterus.
Kirsty I Munro, Michael J Thrippleton, +11 authors, Hilary O D Critchley.
PLoS One, 2014 Mar 13; 9(3). PMID: 24608161    Free PMC article.
The effects of applying breast compression in dynamic contrast material-enhanced MR imaging.
Riham H El Khouli, Katarzyna J Macura, +2 authors, Michael A Jacobs.
Radiology, 2014 Mar 14; 272(1). PMID: 24620911    Free PMC article.
Improving bladder cancer imaging using 3-T functional dynamic contrast-enhanced magnetic resonance imaging.
Huyen T Nguyen, Kamal S Pohar, +7 authors, Michael V Knopp.
Invest Radiol, 2014 Mar 19; 49(6). PMID: 24637583    Free PMC article.
DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker.
Bang-Bin Chen, Tiffany Ting-Fang Shih.
World J Gastroenterol, 2014 Apr 04; 20(12). PMID: 24695624    Free PMC article.
Review.
Dynamic contrast-enhanced magnetic resonance imaging: fundamentals and application to the evaluation of the peripheral perfusion.
Yaron Gordon, Sasan Partovi, +5 authors, Fabian Rengier.
Cardiovasc Diagn Ther, 2014 May 17; 4(2). PMID: 24834412    Free PMC article.
Review.
Prediction of chemotherapeutic response in bladder cancer using K-means clustering of dynamic contrast-enhanced (DCE)-MRI pharmacokinetic parameters.
Huyen T Nguyen, Guang Jia, +7 authors, Michael V Knopp.
J Magn Reson Imaging, 2014 Jun 20; 41(5). PMID: 24943272    Free PMC article.
Muscle-based pharmacokinetic modeling of marrow perfusion for osteoporotic bone in females.
Heather Ting Ma, James F Griffth, Ping-Chung Leung.
Biomed Res Int, 2014 Jul 09; 2014. PMID: 25003121    Free PMC article.
Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer.
Cornelis G van Niekerk, Jeroen A W M van der Laak, +4 authors, Christina A Hulsbergen-van de Kaa.
Eur Radiol, 2014 Jul 19; 24(10). PMID: 25033819
Intraoperative perfusion magnetic resonance imaging: Cutting-edge improvement in neurosurgical procedures.
Stephan Ulmer.
World J Radiol, 2014 Aug 30; 6(8). PMID: 25170392    Free PMC article.
Review.
Modeling the effect of intra-voxel diffusion of contrast agent on the quantitative analysis of dynamic contrast enhanced magnetic resonance imaging.
Stephanie L Barnes, C Chad Quarles, Thomas E Yankeelov.
PLoS One, 2014 Oct 03; 9(9). PMID: 25275536    Free PMC article.
Effects of flip angle uncertainty and noise on the accuracy of DCE-MRI metrics: comparison between standard concentration-based and signal difference methods.
Ping Wang, Yiqun Xue, +3 authors, Hee Kwon Song.
Magn Reson Imaging, 2014 Oct 15; 33(1). PMID: 25311569    Free PMC article.
Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review.
Anna K Heye, Ross D Culling, +2 authors, Joanna M Wardlaw.
Neuroimage Clin, 2014 Nov 08; 6. PMID: 25379439    Free PMC article.
Highly Cited. Systematic Review.
Characterization of bone perfusion by dynamic contrast-enhanced magnetic resonance imaging and positron emission tomography in the Dunkin-Hartley guinea pig model of advanced osteoarthritis.
Jonathan P Dyke, Michael Synan, +3 authors, Roy K Aaron.
J Orthop Res, 2014 Nov 21; 33(3). PMID: 25410523    Free PMC article.
Magnetic resonance-imaging of the effect of targeted antiangiogenic gene delivery in a melanoma tumour model.
Walter Hundt, Silke Steinbach, +4 authors, Samira Guccione.
Eur Radiol, 2014 Nov 30; 25(4). PMID: 25432291
Small changes in bone structure of female α7 nicotinic acetylcholine receptor knockout mice.
Katrin S Lips, Özcan Yanko, +15 authors, Olaf Kilian.
BMC Musculoskelet Disord, 2015 Feb 01; 16. PMID: 25636336    Free PMC article.
Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.
Y Yang, C Gorzelanny, +6 authors, S W Schneider.
Oncogene, 2015 Mar 10; 34(47). PMID: 25745999
Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging predict outcomes of hepatocellular carcinoma receiving radiotherapy with or without thalidomide.
Po-Chin Liang, Hui-Ju Ch'ang, +3 authors, Tsang Wu Liu.
Hepatol Int, 2015 Mar 20; 9(2). PMID: 25788178
Effect of arterial deprivation on growing femoral epiphysis: quantitative magnetic resonance imaging using a piglet model.
Jung-Eun Cheon, Won Joon Yoo, +2 authors, Young Hun Choi.
Korean J Radiol, 2015 May 23; 16(3). PMID: 25995692    Free PMC article.
Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials.
Lucy A Fowkes, Dow-Mu Koh, +4 authors, Andrew D J Pearson.
Pediatr Radiol, 2015 Jun 06; 45(11). PMID: 26045035
Review.
IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model.
Devkumar Mustafi, Sophie-Charlotte Gleber, +8 authors, Aytekin Oto.
AJR Am J Roentgenol, 2015 Aug 22; 205(3). PMID: 26295667    Free PMC article.
Integration of DCE-MRI and DW-MRI Quantitative Parameters for Breast Lesion Classification.
Roberta Fusco, Mario Sansone, +8 authors, Antonella Petrillo.
Biomed Res Int, 2015 Sep 05; 2015. PMID: 26339597    Free PMC article.
Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.
Natalia Arteaga-Marrero, Cecilie Brekke Rygh, +4 authors, Dag R Olsen.
J Transl Med, 2015 Dec 20; 13. PMID: 26682742    Free PMC article.
Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy.
Lele Li, Rong Tong, Mengyuan Li, Daniel S Kohane.
Acta Biomater, 2016 Jan 31; 33. PMID: 26826531    Free PMC article.
Synergistic Effect of Anti-Angiogenic and Radiation Therapy: Quantitative Evaluation with Dynamic Contrast Enhanced MR Imaging.
Hyun Jung Koo, Myoungsun Lee, +5 authors, Jin Seong Lee.
PLoS One, 2016 Feb 11; 11(2). PMID: 26862906    Free PMC article.
Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer.
Sungheon Gene Kim, Kent Friedman, Sohil Patel, Mari Hagiwara.
AJR Am J Roentgenol, 2016 May 11; 207(2). PMID: 27163282    Free PMC article.
Review.
Brain capillary transit time heterogeneity in healthy volunteers measured by dynamic contrast-enhanced T1 -weighted perfusion MRI.
Henrik B W Larsson, Mark B Vestergaard, +2 authors, Stig P Cramer.
J Magn Reson Imaging, 2016 Oct 13; 45(6). PMID: 27731907    Free PMC article.
Functional MRI for quantitative treatment response prediction in locally advanced rectal cancer.
Trang T Pham, Gary P Liney, Karen Wong, Michael B Barton.
Br J Radiol, 2017 Jan 06; 90(1072). PMID: 28055248    Free PMC article.
Review.
A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.
Hunter R Underhill.
Magn Reson Med, 2017 Jan 13; 78(5). PMID: 28078795    Free PMC article.
Whole-body MRI, dynamic contrast-enhanced MRI, and diffusion-weighted imaging for the staging of multiple myeloma.
Julie C Dutoit, Koenraad L Verstraete.
Skeletal Radiol, 2017 Mar 16; 46(6). PMID: 28289855
Review.
Drug-carrying microbubbles as a theranostic tool in convection-enhanced delivery for brain tumor therapy.
Pin-Yuan Chen, Chih-Kuang Yeh, +4 authors, Hao-Li Liu.
Oncotarget, 2017 Apr 19; 8(26). PMID: 28418846    Free PMC article.
Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD.
Chao-Ying Wang, Yu-Juei Hsu, +7 authors, Guo-Shu Huang.
Sci Rep, 2017 Jun 10; 7(1). PMID: 28596576    Free PMC article.
Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters.
Pedro Augusto Gondim Teixeira, Christophe Leplat, +5 authors, Alain Blum.
Eur Radiol, 2017 Jun 16; 27(12). PMID: 28616730
Influence of B1-Inhomogeneity on Pharmacokinetic Modeling of Dynamic Contrast-Enhanced MRI: A Simulation Study.
Bumwoo Park, Byung Se Choi, +8 authors, Jeong Kon Kim.
Korean J Radiol, 2017 Jul 04; 18(4). PMID: 28670153    Free PMC article.
Dynamic contrast-enhanced MRI of the patellar bone: How to quantify perfusion.
Dirk H J Poot, Rianne A van der Heijden, +2 authors, Stefan Klein.
J Magn Reson Imaging, 2017 Jul 15; 47(3). PMID: 28707311    Free PMC article.
Contribution of Circulatory Disturbances in Subchondral Bone to the Pathophysiology of Osteoarthritis.
Roy K Aaron, Jennifer Racine, Jonathan P Dyke.
Curr Rheumatol Rep, 2017 Jul 19; 19(8). PMID: 28718064
Review.
Comparison of perfusion models for quantitative T1 weighted DCE-MRI of rectal cancer.
Tanja Gaa, Wiebke Neumann, +4 authors, Frank G Zöllner.
Sci Rep, 2017 Sep 22; 7(1). PMID: 28931946    Free PMC article.
Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges.
Jie Deng, Yi Wang.
Chronic Dis Transl Med, 2017 Oct 25; 3(1). PMID: 29063052    Free PMC article.
Review.
Evaluation of B1 inhomogeneity effect on DCE-MRI data analysis of brain tumor patients at 3T.
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh.
J Transl Med, 2017 Dec 05; 15(1). PMID: 29197390    Free PMC article.
Robust and efficient pharmacokinetic parameter non-linear least squares estimation for dynamic contrast enhanced MRI of the prostate.
Soudabeh Kargar, Eric A Borisch, +5 authors, Stephen J Riederer.
Magn Reson Imaging, 2017 Dec 27; 48. PMID: 29278764    Free PMC article.
Renal Cell Carcinoma Perfusion before and after Radiofrequency Ablation Measured with Dynamic Contrast Enhanced MRI: A Pilot Study.
Tze Min Wah, Steven Sourbron, +4 authors, David L Buckley.
Diagnostics (Basel), 2018 Jan 11; 8(1). PMID: 29316711    Free PMC article.
Contribution of 18F-FDG PET/CT to Staging of Head and Neck Malignancies.
Yeşim Ceylan, Özgür Ömür, Filiz Hatipoğlu.
Mol Imaging Radionucl Ther, 2018 Feb 03; 27(1). PMID: 29393049    Free PMC article.
Blood perfusion of patellar bone measured by dynamic contrast-enhanced MRI in patients with patellofemoral pain: A case-control study.
Rianne A van der Heijden, Dirk H J Poot, +8 authors, Edwin H G Oei.
J Magn Reson Imaging, 2018 May 08; 48(5). PMID: 29734499    Free PMC article.
Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models.
Stephan Niland, Dorde Komljenovic, +4 authors, Johannes A Eble.
Oncotarget, 2018 Jun 02; 9(32). PMID: 29854288    Free PMC article.
Recent advances in non-invasive magnetic resonance imaging assessment of hepatocellular carcinoma.
Davide Ippolito, Riccardo Inchingolo, +4 authors, Riccardo Faletti.
World J Gastroenterol, 2018 Jun 23; 24(23). PMID: 29930464    Free PMC article.
Review.
Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease.
Cari L Meisel, Polly Bainbridge, Dimitrios Mitsouras, Joyce Y Wong.
ACS Appl Nano Mater, 2018 Sep 28; 1(9). PMID: 31867573    Free PMC article.
Dynamic contrast-enhanced perfusion parameters in ovarian cancer: Good accuracy in identifying high HIF-1α expression.
Auni Lindgren, Maarit Anttila, +5 authors, Hanna Sallinen.
PLoS One, 2019 Aug 23; 14(8). PMID: 31437208    Free PMC article.
Improved detection of a tumorous involvement of the mesorectal fascia and locoregional lymph nodes in locally advanced rectal cancer using DCE-MRI.
Marco Armbruster, Melvin D'Anastasi, +5 authors, Martina Brandlhuber.
Int J Colorectal Dis, 2018 May 19; 33(7). PMID: 29774398
Guiding the first biopsy in glioma patients using estimated Ki-67 maps derived from MRI: conventional versus advanced imaging.
Evan D H Gates, Jonathan S Lin, +7 authors, Dawid Schellingerhout.
Neuro Oncol, 2019 Jan 19; 21(4). PMID: 30657997    Free PMC article.
Dual CTLA-4 and PD-L1 Blockade Inhibits Tumor Growth and Liver Metastasis in a Highly Aggressive Orthotopic Mouse Model of Colon Cancer.
E Fiegle, D Doleschel, +5 authors, W Lederle.
Neoplasia, 2019 Aug 15; 21(9). PMID: 31412307    Free PMC article.
DCE-MRI of locally-advanced carcinoma of the uterine cervix: Tofts analysis versus non-model-based analyses.
Kjersti V Lund, Trude G Simonsen, Gunnar B Kristensen, Einar K Rofstad.
Radiat Oncol, 2020 Apr 16; 15(1). PMID: 32293487    Free PMC article.
Preoperative Prediction of Extramural Venous Invasion in Rectal Cancer: Comparison of the Diagnostic Efficacy of Radiomics Models and Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Xiangling Yu, Wenlong Song, +6 authors, Xinjie Liu.
Front Oncol, 2020 Apr 25; 10. PMID: 32328461    Free PMC article.
A compact solution for estimation of physiological parameters from ultrafast prostate dynamic contrast enhanced MRI.
Dianning He, Xiaobing Fan, +7 authors, Gregory S Karczmar.
Phys Med Biol, 2019 Jun 21; 64(15). PMID: 31220816    Free PMC article.
Assessment of pelvic lymph node metastasis in FIGO IB and IIA cervical cancer using quantitative dynamic contrast-enhanced MRI parameters.
See Hyung Kim, Seung Hyun Cho.
Diagn Interv Radiol, 2020 Jul 17; 26(5). PMID: 32673204    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Recurrent inverted papilloma: diagnosis with pharmacokinetic dynamic gadolinium-enhanced MR imaging.
P H Lai, C F Yang, +6 authors, C N Lee.
AJNR Am J Neuroradiol, 1999 Oct 08; 20(8). PMID: 10512227    Free PMC article.
Overview of dynamic contrast-enhanced MRI in prostate cancer diagnosis and management.
Sadhna Verma, Baris Turkbey, +5 authors, Mukesh Harisinghani.
AJR Am J Roentgenol, 2012 May 25; 198(6). PMID: 22623539    Free PMC article.
Review.
MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging - design, implementation and application on the example of DCE-MRI.
Charlotte Debus, Ralf Floca, +4 authors, Marco Nolden.
BMC Bioinformatics, 2019 Jan 18; 20(1). PMID: 30651067    Free PMC article.
Application of Distributed Parameter Model to Assessment of Glioma IDH Mutation Status by Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Zongfang Li, Wei Zhao, +6 authors, Zujun Hou.
Contrast Media Mol Imaging, 2020 Dec 11; 2020. PMID: 33299387    Free PMC article.
APRICOT: Advanced Platform for Reproducible Infrastructures in the Cloud via Open Tools.
Vicent Giménez-Alventosa, José Damián Segrelles, Germán Moltó, Mar Roca-Sogorb.
Methods Inf Med, 2020 Aug 11; 59(S 02). PMID: 32777825    Free PMC article.