Journal Article
. 1991 Feb;17(2).
doi: 10.1002/mrm.1910170208.

Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts

P S Tofts 1 A G Kermode  
  • PMID: 2062210
  •     351 citations


Leakage of Gd-DTPA through a defective blood-brain barrier is measured quantitatively using dynamic MRI scanning, in which repeated scans are made after a bolus injection. Image registration artifacts are minimized; a dose of 0.1 mM/kg and an IR sequence enable enhancement to be measured quantitatively. The triexponential enhancement curve is fitted to a theoretical model based on compartmental analysis. The transfer constant, or permeability surface area product per unit volume of tissue (k), and leakage space per unit volume of tissue (v1) are measured. Estimates for a quickly enhancing multiple sclerosis lesion are k = 0.050 min-1, v1 = 21%; for a slow one k = 0.013 min-1, v1 = 49%. This implies permeability in the range 4-17 x 10(-6) cm s-1, in broad agreement with other physiological methods. The method is noninvasive and can be used to make serial measurements in patients and in experimental animal models. The time course of pathological aspects of diseases with blood-brain barrier breakdown, such as multiple sclerosis, tumors, and infections (e.g., HIV) can be studied, along with their response to therapy. The measurements are of physiological variables and are therefore independent of imaging equipment and field.

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Evaluation of antiangiogenic effects of a new synthetic candidate drug KR-31831 on xenografted ovarian carcinoma using dynamic contrast enhanced MRI.
Jehoon Yang, Jae-Hun Kim, +5 authors, Pyoung Jeon.
Korean J Radiol, 2011 Sep 20; 12(5). PMID: 21927562    Free PMC article.
Dynamic contrast enhanced-MRI for the detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer.
M J Gollub, D H Gultekin, +14 authors, L H Schwartz.
Eur Radiol, 2011 Nov 22; 22(4). PMID: 22101743
Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study.
Isabelle Thomassin-Naggara, Daniel Balvay, +4 authors, Marc Bazot.
Eur Radiol, 2011 Nov 23; 22(4). PMID: 22105841
Model selection for DCE-T1 studies in glioblastoma.
Hassan Bagher-Ebadian, Rajan Jain, +9 authors, James R Ewing.
Magn Reson Med, 2011 Dec 01; 68(1). PMID: 22127934    Free PMC article.
Can dynamic contrast-enhanced magnetic resonance imaging combined with texture analysis differentiate malignant glioneuronal tumors from other glioblastoma?
Pierre-Antoine Eliat, Damien Olivié, +3 authors, Jacques D de Certaines.
Neurol Res Int, 2011 Dec 29; 2012. PMID: 22203901    Free PMC article.
Advances in MRI-Based Detection of Cerebrovascular Changes after Experimental Traumatic Brain Injury.
Rick M Dijkhuizen.
Transl Stroke Res, 2011 Dec 31; 2(4). PMID: 22207884    Free PMC article.
Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies.
James P B O'Connor, Alan Jackson, +2 authors, Gordon C Jayson.
Nat Rev Clin Oncol, 2012 Feb 15; 9(3). PMID: 22330689
Highly Cited. Review.
Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer.
Joon Seok Lim, Daehong Kim, +8 authors, Ki Chang Keum.
Eur Radiol, 2012 Mar 20; 22(8). PMID: 22427184
Dynamic contrast-enhanced imaging techniques: CT and MRI.
J P B O'Connor, P S Tofts, +3 authors, A Jackson.
Br J Radiol, 2012 May 25; 84 Spec No 2. PMID: 22433822    Free PMC article.
Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.
M O Leach, B Morgan, +27 authors, Experimental Cancer Medicine Centres Imaging Network Steering Committee.
Eur Radiol, 2012 May 09; 22(7). PMID: 22562143
Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters.
C Chad Quarles, John C Gore, Lei Xu, Thomas E Yankeelov.
Magn Reson Imaging, 2012 May 24; 30(7). PMID: 22617148    Free PMC article.
The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound.
Juyoung Park, Yongzhi Zhang, +2 authors, Nathan J McDannold.
J Control Release, 2012 Jun 20; 162(1). PMID: 22709590    Free PMC article.
Evaluation of a voxelized model based on DCE-MRI for tracer transport in tumor.
K N Magdoom, Gregory L Pishko, Jung Hwan Kim, Malisa Sarntinoranont.
J Biomech Eng, 2012 Sep 04; 134(9). PMID: 22938371    Free PMC article.
Pre-treatment differences and early response monitoring of neoadjuvant chemotherapy in breast cancer patients using magnetic resonance imaging: a systematic review.
R Prevos, M L Smidt, +4 authors, M B I Lobbes.
Eur Radiol, 2012 Sep 18; 22(12). PMID: 22983282
Systematic Review.
Advantages of a dual-tracer model over reference tissue models for binding potential measurement in tumors.
K M Tichauer, K S Samkoe, +2 authors, B W Pogue.
Phys Med Biol, 2012 Oct 02; 57(20). PMID: 23022732    Free PMC article.
Advanced techniques using contrast media in neuroimaging.
Jean-Christophe Ferré, Mark S Shiroishi, Meng Law.
Magn Reson Imaging Clin N Am, 2012 Oct 24; 20(4). PMID: 23088946    Free PMC article.
Practical dynamic contrast enhanced MRI in small animal models of cancer: data acquisition, data analysis, and interpretation.
Stephanie L Barnes, Jennifer G Whisenant, Mary E Loveless, Thomas E Yankeelov.
Pharmaceutics, 2012 Oct 30; 4(3). PMID: 23105959    Free PMC article.
Functional imaging in adult and paediatric brain tumours.
Andrew C Peet, Theodoros N Arvanitis, Martin O Leach, Adam D Waldman.
Nat Rev Clin Oncol, 2012 Nov 15; 9(12). PMID: 23149894
Free-breathing dynamic contrast-enhanced MRI of the abdomen and chest using a radial gradient echo sequence with K-space weighted image contrast (KWIC).
Kyung Won Kim, Jeong Min Lee, +10 authors, Chin Kim.
Eur Radiol, 2012 Nov 29; 23(5). PMID: 23187728
Hemodynamic response imaging: a potential tool for the assessment of angiogenesis in brain tumors.
Dafna Ben Bashat, Moran Artzi, +12 authors, Rinat Abramovitch.
PLoS One, 2012 Dec 05; 7(11). PMID: 23209575    Free PMC article.
Parameter optimization for quantitative signal-concentration mapping using spoiled gradient echo MRI.
Gasser Hathout, Neema Jamshidi.
Radiol Res Pract, 2012 Dec 06; 2012. PMID: 23213523    Free PMC article.
A linear algorithm of the reference region model for DCE-MRI is robust and relaxes requirements for temporal resolution.
Julio Cárdenas-Rodríguez, Christine M Howison, Mark D Pagel.
Magn Reson Imaging, 2012 Dec 12; 31(4). PMID: 23228309    Free PMC article.
Perfusion MRI: the five most frequently asked technical questions.
Marco Essig, Mark S Shiroishi, +8 authors, Meng Law.
AJR Am J Roentgenol, 2012 Dec 21; 200(1). PMID: 23255738    Free PMC article.
Quantitative evaluation of dual-flip-angle T1 mapping on DCE-MRI kinetic parameter estimation in head and neck.
Jing Yuan, Steven Kwok Keung Chow, +2 authors, Ann D King.
Quant Imaging Med Surg, 2013 Jan 05; 2(4). PMID: 23289084    Free PMC article.
Differentiation of myeloma and metastatic cancer in the spine using dynamic contrast-enhanced MRI.
Ning Lang, Min-Ying Su, +3 authors, Huishu Yuan.
Magn Reson Imaging, 2013 Jan 08; 31(8). PMID: 23290477    Free PMC article.
Vascular disrupting effect of CKD-516: preclinical study using DCE-MRI.
Kyung Won Kim, Jeong Min Lee, +7 authors, Byung Ihn Choi.
Invest New Drugs, 2013 Jan 10; 31(5). PMID: 23299389
A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium.
Srikala S Sridhar, Mary J Mackenzie, +10 authors, Malcolm J Moore.
Invest New Drugs, 2013 Jan 29; 31(4). PMID: 23354849
Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage.
Bingsheng Huang, Chun-Sing Wong, +4 authors, Pek-Lan Khong.
Eur Radiol, 2013 Feb 05; 23(6). PMID: 23377545
A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models.
Ergys Subashi, Everett J Moding, +4 authors, G Allan Johnson.
Med Phys, 2013 Feb 08; 40(2). PMID: 23387766    Free PMC article.
Quantitative imaging assessment of blood-brain barrier permeability in humans.
Yoash Chassidim, Ronel Veksler, +3 authors, Ilan Shelef.
Fluids Barriers CNS, 2013 Feb 08; 10(1). PMID: 23388348    Free PMC article.
SCUBE3 regulation of early lung cancer angiogenesis and metastatic progression.
Cheng-Hung Chou, Yi-Fang Cheng, +3 authors, Chen Chang.
Clin Exp Metastasis, 2013 Feb 20; 30(6). PMID: 23420440
A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results.
Jacob U Fluckiger, Mary E Loveless, +2 authors, Thomas E Yankeelov.
Phys Med Biol, 2013 Mar 06; 58(6). PMID: 23458745    Free PMC article.
Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer.
Michael Ingrisch, Steven Sourbron.
J Pharmacokinet Pharmacodyn, 2013 Apr 09; 40(3). PMID: 23563847
Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition.
Jose L Ulloa, Simone Stahl, +5 authors, Paul D Hockings.
NMR Biomed, 2013 Apr 09; 26(10). PMID: 23564602    Free PMC article.
Modeling Tumor-Associated Edema in Gliomas during Anti-Angiogenic Therapy and Its Impact on Imageable Tumor.
Andrea Hawkins-Daarud, Russell C Rockne, Alexander R A Anderson, Kristin R Swanson.
Front Oncol, 2013 Apr 12; 3. PMID: 23577324    Free PMC article.
Fluorescent affibody peptide penetration in glioma margin is superior to full antibody.
Kristian Sexton, Kenneth Tichauer, +3 authors, Brian W Pogue.
PLoS One, 2013 Apr 18; 8(4). PMID: 23593208    Free PMC article.
Pharmacodynamic analysis of magnetic resonance imaging-monitored focused ultrasound-induced blood-brain barrier opening for drug delivery to brain tumors.
Po-Chun Chu, Wen-Yen Chai, +5 authors, Hao-Li Liu.
Biomed Res Int, 2013 Apr 23; 2013. PMID: 23607093    Free PMC article.
Early detection of Lewis lung carcinoma tumor control by irradiation using diffusion-weighted and dynamic contrast-enhanced MRI.
Jason Chia-Hsien Cheng, Ang Yuan, +6 authors, Pan-Chyr Yang.
PLoS One, 2013 May 10; 8(5). PMID: 23658769    Free PMC article.
Statistical Learning Algorithm for in situ and invasive breast carcinoma segmentation.
Jagadeesan Jayender, Eva Gombos, +3 authors, Kirby G Vosburgh.
Comput Med Imaging Graph, 2013 May 23; 37(4). PMID: 23693000    Free PMC article.
Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors.
Divya Khaitan, Nagendra S Ningaraj.
Front Pharmacol, 2013 Jun 12; 4. PMID: 23755013    Free PMC article.
Dynamic contrast-enhanced MRI-based biomarkers of therapeutic response in triple-negative breast cancer.
Daniel I Golden, Jafi A Lipson, +2 authors, Daniel L Rubin.
J Am Med Inform Assoc, 2013 Jun 21; 20(6). PMID: 23785100    Free PMC article.
Clinical application of magnetic resonance imaging in management of breast cancer patients receiving neoadjuvant chemotherapy.
Jeon-Hor Chen, Min-Ying Su.
Biomed Res Int, 2013 Jul 19; 2013. PMID: 23862143    Free PMC article.
Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T.
Madhava P Aryal, Tavarekere N Nagaraja, +6 authors, James R Ewing.
Magn Reson Med, 2013 Jul 24; 71(6). PMID: 23878070    Free PMC article.
Model selection in measures of vascular parameters using dynamic contrast-enhanced MRI: experimental and clinical applications.
James R Ewing, Hassan Bagher-Ebadian.
NMR Biomed, 2013 Jul 25; 26(8). PMID: 23881857    Free PMC article.
Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study.
Xiao-Er Wei, Yue-Hua Li, +3 authors, Wen-Bin Li.
Neurol Sci, 2013 Aug 21; 35(2). PMID: 23955096
Prognostic aspects of DCE-MRI in recurrent rectal cancer.
M J Gollub, K Cao, +12 authors, P B Paty.
Eur Radiol, 2013 Aug 28; 23(12). PMID: 23979104
Periodicity in tumor vasculature targeting kinetics of ligand-functionalized nanoparticles studied by dynamic contrast enhanced magnetic resonance imaging and intravital microscopy.
Sjoerd Hak, Jana Cebulla, +4 authors, Olav Haraldseth.
Angiogenesis, 2013 Aug 29; 17(1). PMID: 23982332    Free PMC article.
MRI of blood-brain barrier permeability in cerebral ischemia.
Quan Jiang, James R Ewing, Michael Chopp.
Transl Stroke Res, 2012 Mar 01; 3(1). PMID: 23997835    Free PMC article.
A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics.
Shengping Qin, Brett Z Fite, +4 authors, Katherine W Ferrara.
Ann Biomed Eng, 2013 Sep 11; 42(2). PMID: 24018607    Free PMC article.
Automatic segmentation of invasive breast carcinomas from dynamic contrast-enhanced MRI using time series analysis.
Jagadaeesan Jayender, Sona Chikarmane, Ferenc A Jolesz, Eva Gombos.
J Magn Reson Imaging, 2013 Oct 12; 40(2). PMID: 24115175    Free PMC article.
Dynamic contrast-enhanced magnetic resonance imaging can assess vascularity within fracture non-unions and predicts good outcome.
Oliver Schoierer, Konstantin Bloess, +4 authors, Marc-André Weber.
Eur Radiol, 2013 Oct 23; 24(2). PMID: 24145951
Evaluation of laser speckle contrast imaging as an intrinsic method to monitor blood brain barrier integrity.
Suzie Dufour, Yaaseen Atchia, +3 authors, Ofer Levi.
Biomed Opt Express, 2013 Oct 25; 4(10). PMID: 24156049    Free PMC article.
Dependence of the reversibility of focused- ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo.
Gesthimani Samiotaki, Elisa E Konofagou.
IEEE Trans Ultrason Ferroelectr Freq Control, 2013 Oct 26; 60(11). PMID: 24158283    Free PMC article.
Optical imaging to map blood-brain barrier leakage.
Hayder Jaffer, Isaac M Adjei, Vinod Labhasetwar.
Sci Rep, 2013 Nov 02; 3. PMID: 24178124    Free PMC article.
DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data.
Juan E Ortuño, María J Ledesma-Carbayo, +3 authors, Andrés Santos.
BMC Bioinformatics, 2013 Nov 05; 14. PMID: 24180558    Free PMC article.
Perfusion parameters of dynamic contrast-enhanced magnetic resonance imaging in patients with rectal cancer: correlation with microvascular density and vascular endothelial growth factor expression.
Yeo-Eun Kim, Joon Seok Lim, +4 authors, Ki Whang Kim.
Korean J Radiol, 2013 Nov 23; 14(6). PMID: 24265562    Free PMC article.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Preclinical Studies of Antivascular Treatments.
Thomas Nielsen, Thomas Wittenborn, Michael R Horsman.
Pharmaceutics, 2012 Jan 01; 4(4). PMID: 24300371    Free PMC article.
High-field small animal magnetic resonance oncology studies.
Louisa Bokacheva, Ellen Ackerstaff, +2 authors, Jason A Koutcher.
Phys Med Biol, 2014 Jan 01; 59(2). PMID: 24374985    Free PMC article.
Measurement of rat brain tumor kinetics using an intravascular MR contrast agent and DCE-MRI nested model selection.
Wilson B Chwang, Rajan Jain, +6 authors, James R Ewing.
J Magn Reson Imaging, 2014 Jan 15; 40(5). PMID: 24421265    Free PMC article.
Could magnetic resonance provide in vivo histology?
Marco Dominietto, Markus Rudin.
Front Genet, 2014 Jan 24; 4. PMID: 24454320    Free PMC article.
Real-time, transcranial monitoring of safe blood-brain barrier opening in non-human primates.
Fabrice Marquet, Tobias Teichert, +6 authors, Elisa E Konofagou.
PLoS One, 2014 Feb 08; 9(2). PMID: 24505248    Free PMC article.
Interpreting therapeutic effect in multiple sclerosis via MRI contrast enhancing lesions: now you see them, now you don't.
Ilana R Leppert, S Narayanan, +4 authors, G B Pike.
J Neurol, 2014 Feb 27; 261(4). PMID: 24570281
Tumor vascularity and glucose metabolism correlated in adenocarcinoma, but not in squamous cell carcinoma of the lung.
Jiuquan Zhang, Lihua Chen, +4 authors, Jian Wang.
PLoS One, 2014 Mar 13; 9(3). PMID: 24614132    Free PMC article.
Assessment of irradiated brain metastases using dynamic contrast-enhanced magnetic resonance imaging.
Daniela B Almeida-Freitas, Marco C Pinho, +3 authors, Claudia da Costa Leite.
Neuroradiology, 2014 Mar 22; 56(6). PMID: 24652530
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease.
Jan Klohs, Markus Rudin, Derya R Shimshek, Nicolau Beckmann.
Front Aging Neurosci, 2014 Mar 25; 6. PMID: 24659966    Free PMC article.
Pharmacokinetic changes induced by focused ultrasound in glioma-bearing rats as measured by dynamic contrast-enhanced MRI.
Feng-Yi Yang, Chia-En Ko, +2 authors, Gin-Shin Chen.
PLoS One, 2014 Mar 29; 9(3). PMID: 24670992    Free PMC article.
Variations of dynamic contrast-enhanced magnetic resonance imaging in evaluation of breast cancer therapy response: a multicenter data analysis challenge.
Wei Huang, Xin Li, +22 authors, Jayashree Kalpathy-Cramer.
Transl Oncol, 2014 Apr 29; 7(1). PMID: 24772219    Free PMC article.
Dynamic contrast-enhanced magnetic resonance imaging: fundamentals and application to the evaluation of the peripheral perfusion.
Yaron Gordon, Sasan Partovi, +5 authors, Fabian Rengier.
Cardiovasc Diagn Ther, 2014 May 17; 4(2). PMID: 24834412    Free PMC article.
Potential of hybrid ¹⁸F-fluorocholine PET/MRI for prostate cancer imaging.
Thomas de Perrot, Olivier Rager, +5 authors, Jean-Paul Vallee.
Eur J Nucl Med Mol Imaging, 2014 May 21; 41(9). PMID: 24841413
Focused ultrasound simultaneous irradiation/MRI imaging, and two-stage general kinetic model.
Sheng-Yao Huang, Chia-En Ko, +2 authors, Feng-Yi Yang.
PLoS One, 2014 Jun 21; 9(6). PMID: 24949997    Free PMC article.
Accurate determination of blood-brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients.
Stig P Cramer, Henrik B W Larsson.
J Cereb Blood Flow Metab, 2014 Jul 31; 34(10). PMID: 25074746    Free PMC article.
Assessment of Progression-Free-Survival in Glioblastomas by Intratreatment Dynamic Contrast-Enhanced MRI.
S Bisdas, U Smrdel, F F Bajrovic, K Surlan-Popovic.
Clin Neuroradiol, 2014 Aug 29; 26(1). PMID: 25164691
Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques.
Geon-Ho Jahng, Ka-Loh Li, Leif Ostergaard, Fernando Calamante.
Korean J Radiol, 2014 Sep 24; 15(5). PMID: 25246817    Free PMC article.
Modeling the effect of intra-voxel diffusion of contrast agent on the quantitative analysis of dynamic contrast enhanced magnetic resonance imaging.
Stephanie L Barnes, C Chad Quarles, Thomas E Yankeelov.
PLoS One, 2014 Oct 03; 9(9). PMID: 25275536    Free PMC article.
Distribution of Intravascular and Extravascular Extracellular Volume Fractions by Total Area under Curve for Neovascularization Assessment by Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Yi Sun.
J Med Signals Sens, 2014 Oct 10; 4(3). PMID: 25298925    Free PMC article.
Effects of flip angle uncertainty and noise on the accuracy of DCE-MRI metrics: comparison between standard concentration-based and signal difference methods.
Ping Wang, Yiqun Xue, +3 authors, Hee Kwon Song.
Magn Reson Imaging, 2014 Oct 15; 33(1). PMID: 25311569    Free PMC article.
Review of treatment assessment using DCE-MRI in breast cancer radiation therapy.
Chun-Hao Wang, Fang-Fang Yin, Janet Horton, Zheng Chang.
World J Methodol, 2014 Oct 22; 4(2). PMID: 25332905    Free PMC article.
Classification of tumor area using combined DCE and DSC MRI in patients with glioblastoma.
Moran Artzi, Deborah T Blumenthal, +4 authors, Dafna Ben Bashat.
J Neurooncol, 2014 Nov 06; 121(2). PMID: 25370705
Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review.
Anna K Heye, Ross D Culling, +2 authors, Joanna M Wardlaw.
Neuroimage Clin, 2014 Nov 08; 6. PMID: 25379439    Free PMC article.
Highly Cited. Systematic Review.
From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain.
Yuki Mori, Ting Chen, +7 authors, Yoshichika Yoshioka.
Sci Rep, 2014 Nov 12; 4. PMID: 25385430    Free PMC article.
Characterizing the peritumoral brain zone in glioblastoma: a multidisciplinary analysis.
Jean-Michel Lemée, Anne Clavreul, +7 authors, Philippe Menei.
J Neurooncol, 2015 Jan 07; 122(1). PMID: 25559687
Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo.
Gesthimani Samiotaki, Camilo Acosta, Shutao Wang, Elisa E Konofagou.
J Cereb Blood Flow Metab, 2015 Jan 15; 35(4). PMID: 25586140    Free PMC article.
How critical is the blood-brain barrier to the development of neurotherapeutics?
Carmen Kut, Stuart A Grossman, Jaishri Blakeley.
JAMA Neurol, 2015 Feb 03; 72(4). PMID: 25642802    Free PMC article.
The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher.
Adam Chodobski, Jean-François Ghersi-Egea, +2 authors, Joanna Szmydynger-Chodobska.
Fluids Barriers CNS, 2015 Mar 10; 12. PMID: 25745556    Free PMC article.
Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model.
Muna Aryal, Juyoung Park, +2 authors, Nathan McDannold.
Phys Med Biol, 2015 Mar 10; 60(6). PMID: 25746014    Free PMC article.
Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI.
Ning Lang, Min-Ying Su, Hon J Yu, Huishu Yuan.
Eur Spine J, 2015 Mar 10; 24(8). PMID: 25749725    Free PMC article.
Pitfalls in the neuroimaging of glioblastoma in the era of antiangiogenic and immuno/targeted therapy - detecting illusive disease, defining response.
Raymond Y Huang, Martha R Neagu, David A Reardon, Patrick Y Wen.
Front Neurol, 2015 Mar 11; 6. PMID: 25755649    Free PMC article.
Highly Cited. Review.
Dynamic Contrast-Enhanced MRI in the Study of Brain Tumors. Comparison Between the Extended Tofts-Kety Model and a Phenomenological Universalities (PUN) Algorithm.
Maurizio Bergamino, Laura Barletta, +2 authors, Luca Roccatagliata.
J Digit Imaging, 2015 Mar 18; 28(6). PMID: 25776769    Free PMC article.
Human cerebral blood volume measurements using dynamic contrast enhancement in comparison to dynamic susceptibility contrast MRI.
Moran Artzi, Gilad Liberman, +5 authors, Dafna Ben Bashat.
Neuroradiology, 2015 Apr 08; 57(7). PMID: 25845809
Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging.
Xiaoguang Li, Yongshan Zhu, +4 authors, Weiguo Zhang.
Cancer Imaging, 2015 Apr 19; 15. PMID: 25889239    Free PMC article.
Compressive sensing in medical imaging.
Christian G Graff, Emil Y Sidky.
Appl Opt, 2015 May 15; 54(8). PMID: 25968400    Free PMC article.
Effect of arterial deprivation on growing femoral epiphysis: quantitative magnetic resonance imaging using a piglet model.
Jung-Eun Cheon, Won Joon Yoo, +2 authors, Young Hun Choi.
Korean J Radiol, 2015 May 23; 16(3). PMID: 25995692    Free PMC article.
Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3.
Mitchell Kamrava, Ali R Sepahdari, +5 authors, Benjamin M Ellingson.
Neuroradiology, 2015 May 30; 57(8). PMID: 26022354
Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials.
Lucy A Fowkes, Dow-Mu Koh, +4 authors, Andrew D J Pearson.
Pediatr Radiol, 2015 Jun 06; 45(11). PMID: 26045035
Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI.
Samuel R Barnes, Thomas S C Ng, +3 authors, Russell E Jacobs.
Magn Reson Med, 2015 Jun 17; 75(5). PMID: 26077645    Free PMC article.
A Proposed Paradigm Shift in Initializing Cancer Predictive Models with DCE-MRI Based PK Parameters: A Feasibility Study.
Alexandros Roniotis, Mariam-Eleni Oraiopoulou, +4 authors, Kostas Marias.
Cancer Inform, 2015 Jun 19; 14(Suppl 4). PMID: 26085787    Free PMC article.
What are white matter hyperintensities made of? Relevance to vascular cognitive impairment.
Joanna M Wardlaw, Maria C Valdés Hernández, Susana Muñoz-Maniega.
J Am Heart Assoc, 2015 Jun 25; 4(6). PMID: 26104658    Free PMC article.
Highly Cited. Review.
MRI in multiple sclerosis: an intra-individual, randomized and multicentric comparison of gadobutrol with gadoterate meglumine at 3 T.
Marc Saake, Soenke Langner, +4 authors, Arnd Doerfler.
Eur Radiol, 2015 Jul 01; 26(3). PMID: 26123410
Dependence of DCE-MRI biomarker values on analysis algorithm.
Chaan S Ng, Wei Wei, +6 authors, Edward F Jackson.
PLoS One, 2015 Jul 25; 10(7). PMID: 26208254    Free PMC article.
In Vivo Correlation of Glucose Metabolism, Cell Density and Microcirculatory Parameters in Patients with Head and Neck Cancer: Initial Results Using Simultaneous PET/MRI.
Matthias Gawlitza, Sandra Purz, +6 authors, Patrick Stumpp.
PLoS One, 2015 Aug 14; 10(8). PMID: 26270054    Free PMC article.
Multimodality Brain Tumor Imaging: MR Imaging, PET, and PET/MR Imaging.
James R Fink, Mark Muzi, Melinda Peck, Kenneth A Krohn.
J Nucl Med, 2015 Aug 22; 56(10). PMID: 26294301    Free PMC article.
Assessing Treatment Response Through Generalized Pharmacokinetic Modeling of DCE-MRI Data.
Eleftherios Kontopodis, Georgia Kanli, +2 authors, Kostas Marias.
Cancer Inform, 2015 Sep 04; 14(Suppl 4). PMID: 26327778    Free PMC article.
Validation of a T1 and T2* leakage correction method based on multiecho dynamic susceptibility contrast MRI using MION as a reference standard.
Ashley M Stokes, Natenael Semmineh, C Chad Quarles.
Magn Reson Med, 2015 Sep 13; 76(2). PMID: 26362714    Free PMC article.
Reproducibility of Dynamic Contrast-Enhanced MRI in Renal Cell Carcinoma: A Prospective Analysis on Intra- and Interobserver and Scan-Rescan Performance of Pharmacokinetic Parameters.
Haiyi Wang, Zihua Su, +7 authors, Lin Ma.
Medicine (Baltimore), 2015 Sep 17; 94(37). PMID: 26376399    Free PMC article.
Tumor Vascularity in Renal Masses: Correlation of Arterial Spin-Labeled and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Assessments.
Yue Zhang, Payal Kapur, +10 authors, Ivan Pedrosa.
Clin Genitourin Cancer, 2015 Oct 01; 14(1). PMID: 26422014    Free PMC article.
Assessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using DCE-MRI.
J Guo, J O Glass, +11 authors, W E Reddick.
Br J Cancer, 2015 Oct 16; 113(9). PMID: 26461056    Free PMC article.
Radiotherapy planning using MRI.
Maria A Schmidt, Geoffrey S Payne.
Phys Med Biol, 2015 Oct 29; 60(22). PMID: 26509844    Free PMC article.
Multiparametric MR Imaging of Breast Cancer.
Habib Rahbar, Savannah C Partridge.
Magn Reson Imaging Clin N Am, 2015 Nov 29; 24(1). PMID: 26613883    Free PMC article.
Multiparametric fully-integrated 18-FDG PET/MRI of advanced gastric cancer for prediction of chemotherapy response: a preliminary study.
Dong Ho Lee, Se Hyung Kim, +3 authors, Joon Koo Han.
Eur Radiol, 2015 Nov 30; 26(8). PMID: 26615555
DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model--initial experience.
Guido H Jajamovich, Wei Huang, +4 authors, Bachir Taouli.
MAGMA, 2015 Dec 10; 29(1). PMID: 26646522    Free PMC article.
DCE-MRI for Pre-Treatment Prediction and Post-Treatment Assessment of Treatment Response in Sites of Squamous Cell Carcinoma in the Head and Neck.
Ann D King, Steven Kwok Keung Chow, +7 authors, Anil T Ahuja.
PLoS One, 2015 Dec 15; 10(12). PMID: 26657972    Free PMC article.
Optimization of Look-Locker Turbo-Field Echo-Planar Imaging and Evaluation of Its Accuracy in Head and Neck 3D T1 Mapping.
Masanori Maehara, Masahiko Monma, +2 authors, Yukiko Fukuma.
Magn Reson Med Sci, 2016 Jan 05; 15(3). PMID: 26726016    Free PMC article.
Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI.
Moran Artzi, Gilad Liberman, +4 authors, Dafna Ben Bashat.
J Neurooncol, 2016 Jan 13; 127(3). PMID: 26754857
Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis.
Michael O Breckwoldt, Julia Bode, +19 authors, Björn Tews.
Elife, 2016 Feb 03; 5. PMID: 26830460    Free PMC article.
Permeability imaging in pediatric brain tumors.
Sandi Lam, Yimo Lin, Peter C Warnke.
Transl Pediatr, 2014 Jul 01; 3(3). PMID: 26835339    Free PMC article.
Dynamic contrast-enhanced MRI, diffusion-weighted MRI and 18F-FDG PET/CT for the prediction of survival in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiation.
Shu-Hang Ng, Chun-Ta Liao, +9 authors, Jiun-Jie Wang.
Eur Radiol, 2016 Feb 26; 26(11). PMID: 26911889
Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease.
Susana Muñoz Maniega, Francesca M Chappell, +8 authors, Joanna M Wardlaw.
J Cereb Blood Flow Metab, 2016 Mar 05; 37(2). PMID: 26933133    Free PMC article.
Highly Cited.
Early Prediction and Evaluation of Breast Cancer Response to Neoadjuvant Chemotherapy Using Quantitative DCE-MRI.
Alina Tudorica, Karen Y Oh, +10 authors, Wei Huang.
Transl Oncol, 2016 Mar 08; 9(1). PMID: 26947876    Free PMC article.
DCE-MRI and IVIM-MRI of rabbit Vx2 tumors treated with MR-HIFU-induced mild hyperthermia.
Mie K Lam, Chris Oerlemans, +6 authors, Lambertus W Bartels.
J Ther Ultrasound, 2016 Mar 17; 4. PMID: 26981241    Free PMC article.
Bolus arrival time and its effect on tissue characterization with dynamic contrast-enhanced magnetic resonance imaging.
Alireza Mehrtash, Sandeep N Gupta, +5 authors, Andriy Fedorov.
J Med Imaging (Bellingham), 2016 Mar 19; 3(1). PMID: 26989759    Free PMC article.
The Role of Dynamic Contrast-Enhanced MR in Evaluating Level III Collateral Circulation in a Rat Model of Acute Ischemic Stroke.
Hui Chen, Nan Liu, +4 authors, Jun Hu.
Mol Neurobiol, 2016 Mar 24; 54(4). PMID: 27003821
Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange.
K Leu, J L Boxerman, +5 authors, B M Ellingson.
AJNR Am J Neuroradiol, 2016 Apr 16; 37(8). PMID: 27079371    Free PMC article.
Pulsed arterial spin labelling at ultra-high field with a B 1 (+) -optimised adiabatic labelling pulse.
Fabian Zimmer, Kieran O'Brien, +3 authors, Markus Barth.
MAGMA, 2016 Apr 17; 29(3). PMID: 27084187
Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature.
Raf H M van Hoof, Sylvia Heeneman, Joachim E Wildberger, M Eline Kooi.
Curr Atheroscler Rep, 2016 Apr 27; 18(6). PMID: 27115144    Free PMC article.
Vascular assessment of liver disease-towards a new frontier in MRI.
Manil D Chouhan, Mark F Lythgoe, Rajeshwar P Mookerjee, Stuart A Taylor.
Br J Radiol, 2016 Apr 27; 89(1064). PMID: 27115318    Free PMC article.
High-resolution whole-brain DCE-MRI using constrained reconstruction: Prospective clinical evaluation in brain tumor patients.
Yi Guo, R Marc Lebel, +4 authors, Krishna Nayak.
Med Phys, 2016 May 06; 43(5). PMID: 27147313    Free PMC article.
Potential Role of PET/MRI for Imaging Metastatic Lymph Nodes in Head and Neck Cancer.
Sungheon Gene Kim, Kent Friedman, Sohil Patel, Mari Hagiwara.
AJR Am J Roentgenol, 2016 May 11; 207(2). PMID: 27163282    Free PMC article.
Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.
Chunhao Wang, Ergys Subashi, +2 authors, Zheng Chang.
Phys Med Biol, 2016 Jun 09; 61(13). PMID: 27272391    Free PMC article.
Prognosis prediction of non-enhancing T2 high signal intensity lesions in glioblastoma patients after standard treatment: application of dynamic contrast-enhanced MR imaging.
Rihyeon Kim, Seung Hong Choi, +8 authors, Il Han Kim.
Eur Radiol, 2016 Jul 01; 27(3). PMID: 27357131
Dynamic Contrast-enhanced MR Imaging in Renal Cell Carcinoma: Reproducibility of Histogram Analysis on Pharmacokinetic Parameters.
Hai-Yi Wang, Zi-Hua Su, +9 authors, Hui-Yi Ye.
Sci Rep, 2016 Jul 07; 6. PMID: 27380733    Free PMC article.
Assessment of the myelin water fraction in rodent spinal cord using T2-prepared ultrashort echo time MRI.
Tim Klasen, Cornelius Faber.
MAGMA, 2016 Jul 11; 29(6). PMID: 27394911
Short-term follow-up MRI after unplanned resection of malignant soft-tissue tumours; quantitative measurements on dynamic contrast enhanced and diffusion-weighted MR images.
Jeung Il Kim, In Sook Lee, +3 authors, Jong Woon Song.
Br J Radiol, 2016 Jul 28; 89(1066). PMID: 27459249    Free PMC article.
Morphological and dynamic contrast enhanced MR imaging features for the differentiation of chordoma and giant cell tumors in the Axial Skeleton.
Ning Lang, Min-Ying Su, +2 authors, Huishu Yuan.
J Magn Reson Imaging, 2016 Aug 05; 45(4). PMID: 27490009    Free PMC article.
Value of intravoxel incoherent motion and dynamic contrast-enhanced MRI for predicting the early and short-term responses to chemoradiotherapy in nasopharyngeal carcinoma.
Jing Hou, Xiaoping Yu, +7 authors, Wenbin Zeng.
Medicine (Baltimore), 2016 Sep 02; 95(35). PMID: 27583847    Free PMC article.
Comparison of Cerebral Blood Volume and Plasma Volume in Untreated Intracranial Tumors.
Soha Bazyar, Joana Ramalho, +2 authors, Yueh Z Lee.
PLoS One, 2016 Sep 02; 11(9). PMID: 27584684    Free PMC article.
Assessment of Blood-Brain Barrier Permeability by Dynamic Contrast-Enhanced MRI in Transient Middle Cerebral Artery Occlusion Model after Localized Brain Cooling in Rats.
Eun Soo Kim, Seung-Koo Lee, +5 authors, Kwan Seop Lee.
Korean J Radiol, 2016 Sep 03; 17(5). PMID: 27587960    Free PMC article.
Estimation of contrast agent bolus arrival delays for improved reproducibility of liver DCE MRI.
Manil D Chouhan, Alan Bainbridge, +4 authors, Stuart A Taylor.
Phys Med Biol, 2016 Sep 13; 61(19). PMID: 27618594    Free PMC article.
Radiation injury versus malignancy after stereotactic radiosurgery for brain metastases: impact of time-dependent changes in lesion morphology on MRI.
Sabine Wagner, Heinrich Lanfermann, Gerrit Eichner, Hubert Gufler.
Neuro Oncol, 2016 Sep 17; 19(4). PMID: 27634933    Free PMC article.
A novel anthropomorphic flow phantom for the quantitative evaluation of prostate DCE-MRI acquisition techniques.
Silvin P Knight, Jacinta E Browne, +2 authors, Andrew J Fagan.
Phys Med Biol, 2016 Oct 04; 61(20). PMID: 27694709    Free PMC article.
Functional magnetic resonance imaging techniques and their development for radiation therapy planning and monitoring in the head and neck cancers.
Jing Yuan, Gladys Lo, Ann D King.
Quant Imaging Med Surg, 2016 Oct 07; 6(4). PMID: 27709079    Free PMC article.
Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption.
Juyoung Park, Muna Aryal, +2 authors, Nathan McDannold.
J Control Release, 2016 Oct 16; 250. PMID: 27742444    Free PMC article.
Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients.
Agne Ulyte, Vasileios K Katsaros, +5 authors, Sotirios Bisdas.
Neuroradiology, 2016 Nov 01; 58(12). PMID: 27796446    Free PMC article.
Quantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy.
Tom J L Schreurs, Stefanie J Hectors, +3 authors, Gustav J Strijkers.
PLoS One, 2016 Nov 08; 11(11). PMID: 27820832    Free PMC article.
Quantification of antiangiogenic treatment effects on tissue heterogeneity in glioma tumour xenograft model using a combination of DCE-MRI and 3D-ultramicroscopy.
Marco Dominietto, Michael Dobosz, +4 authors, Markus Rudin.
Eur Radiol, 2016 Nov 11; 27(7). PMID: 27830379
Quantifying Intracranial Plaque Permeability with Dynamic Contrast-Enhanced MRI: A Pilot Study.
P Vakil, A H Elmokadem, +4 authors, S A Ansari.
AJNR Am J Neuroradiol, 2016 Nov 20; 38(2). PMID: 27856437    Free PMC article.
Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma.
Alexey Surov, Hans Jonas Meyer, +4 authors, Patrick Stumpp.
Transl Oncol, 2016 Nov 27; 10(1). PMID: 27888709    Free PMC article.
Quantitative T1-mapping detects cloudy-enhancing tumor compartments predicting outcome of patients with glioblastoma.
Andreas Müller, Alina Jurcoane, +8 authors, Elke Hattingen.
Cancer Med, 2016 Nov 29; 6(1). PMID: 27891815    Free PMC article.
Pharmacokinetic analysis and drug delivery efficiency of the focused ultrasound-induced blood-brain barrier opening in non-human primates.
Gesthimani Samiotaki, Maria Eleni Karakatsani, +4 authors, Elisa E Konofagou.
Magn Reson Imaging, 2016 Dec 06; 37. PMID: 27916657    Free PMC article.
Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study.
Roh-Eul Yoo, Seung Hong Choi, +11 authors, Chul-Ho Sohn.
Eur Radiol, 2016 Dec 16; 27(8). PMID: 27975145
Improved hepatic arterial fraction estimation using cardiac output correction of arterial input functions for liver DCE MRI.
Manil D Chouhan, Alan Bainbridge, +4 authors, Stuart A Taylor.
Phys Med Biol, 2016 Dec 22; 62(4). PMID: 28002045    Free PMC article.
Simultaneous PET/MRI assessment of response to cytotoxic and hormone neo-adjuvant chemotherapy in breast cancer: a preliminary report.
Valeria Romeo, Massimiliano D'Aiuto, +2 authors, Emanuele Nicolai.
Med Oncol, 2016 Dec 31; 34(2). PMID: 28035580
A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.
Hunter R Underhill.
Magn Reson Med, 2017 Jan 13; 78(5). PMID: 28078795    Free PMC article.
Spiral Perfusion Imaging With Consecutive Echoes (SPICE™) for the Simultaneous Mapping of DSC- and DCE-MRI Parameters in Brain Tumor Patients: Theory and Initial Feasibility.
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda.
Tomography, 2017 Jan 17; 2(4). PMID: 28090589    Free PMC article.
Diagnosis of Spinal Lesions Using Heuristic and Pharmacokinetic Parameters Measured by Dynamic Contrast-Enhanced MRI.
Ning Lang, Huishu Yuan, Hon J Yu, Min-Ying Su.
Acad Radiol, 2017 Feb 07; 24(7). PMID: 28162875    Free PMC article.
Improved multiparametric MRI discrimination between low-risk prostate cancer and benign tissues in a small cohort of 5α-reductase inhibitor treated individuals as compared with an untreated cohort.
Olga Starobinets, John Kurhanewicz, Susan M Noworolski.
NMR Biomed, 2017 Feb 07; 30(5). PMID: 28164396    Free PMC article.
Response-Derived Input Function Estimation for Dynamic Contrast-Enhanced MRI Demonstrated by Anti-DLL4 Treatment in a Murine U87 Xenograft Model.
Matthew D Silva, Brittany Yerby, +4 authors, Sharon E Ungersma.
Mol Imaging Biol, 2017 Mar 08; 19(5). PMID: 28265853
Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors.
Rebecca W Pak, Darian H Hadjiabadi, +4 authors, Arvind P Pathak.
J Cereb Blood Flow Metab, 2017 May 12; 37(11). PMID: 28492341    Free PMC article.
MRI in Glioma Immunotherapy: Evidence, Pitfalls, and Perspectives.
Domenico Aquino, Andrea Gioppo, +2 authors, Valeria Cuccarini.
J Immunol Res, 2017 May 18; 2017. PMID: 28512646    Free PMC article.
Differentiating between Central Nervous System Lymphoma and High-grade Glioma Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced MR Imaging with Histogram Analysis.
Kazuhiro Murayama, Yuya Nishiyama, +6 authors, Hiroshi Toyama.
Magn Reson Med Sci, 2017 May 19; 17(1). PMID: 28515410    Free PMC article.
T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients.
Bruno-Bernard Rochetams, Bénédicte Marechal, +4 authors, Baptiste Morel.
Neuroradiol J, 2017 May 31; 30(5). PMID: 28556691    Free PMC article.
Intravoxel incoherent motion and dynamic contrast-enhanced MRI for differentiation between hepatocellular adenoma and focal nodular hyperplasia.
Naim Jerjir, Luk Bruyneel, +2 authors, Kenneth Coenegrachts.
Br J Radiol, 2017 Jun 08; 90(1076). PMID: 28590780    Free PMC article.
Dynamic Contrast-enhanced MRI in Renal Tumors: Common Subtype Differentiation using Pharmacokinetics.
Hai-Yi Wang, Zi-Hua Su, +9 authors, Hui-Yi Ye.
Sci Rep, 2017 Jun 10; 7(1). PMID: 28596583    Free PMC article.
Automatic Segmentation of Breast Carcinomas from DCE-MRI using a Statistical Learning Algorithm.
J Jayender, K G Vosburgh, +5 authors, K Pohl.
Proc IEEE Int Symp Biomed Imaging, 2012 May 01; 2012. PMID: 28603582    Free PMC article.
DCE-MRI Texture Features for Early Prediction of Breast Cancer Therapy Response.
Guillaume Thibault, Alina Tudorica, +10 authors, Xubo Song.
Tomography, 2017 Jul 12; 3(1). PMID: 28691102    Free PMC article.
Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.
Haojun Chen, Xiao Tong, +9 authors, Xiaoyuan Chen.
Theranostics, 2017 Jul 27; 7(9). PMID: 28744320    Free PMC article.
Diagnostic value of semi-quantitative and quantitative analysis of functional parameters in multiparametric MRI of the prostate.
Elke Hauth, Daniela Halbritter, +2 authors, Meinrad Beer.
Br J Radiol, 2017 Jul 28; 90(1078). PMID: 28749167    Free PMC article.
A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations.
Joint Head and Neck Radiotherapy-MRI Development Cooperative.
Sci Rep, 2017 Sep 13; 7(1). PMID: 28894197    Free PMC article.
Joint arterial input function and tracer kinetic parameter estimation from undersampled dynamic contrast-enhanced MRI using a model consistency constraint.
Yi Guo, Sajan Goud Lingala, +3 authors, Krishna S Nayak.
Magn Reson Med, 2017 Sep 15; 79(5). PMID: 28905411    Free PMC article.
Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol.
Joao Prola Netto, Jeffrey Iliff, +16 authors, Edward A Neuwelt.
Neurosurgery, 2017 Oct 04; 82(6). PMID: 28973554    Free PMC article.
Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges.
Jie Deng, Yi Wang.
Chronic Dis Transl Med, 2017 Oct 25; 3(1). PMID: 29063052    Free PMC article.
Associations between 18F-FDG-PET, DWI, and DCE Parameters in Patients with Head and Neck Squamous Cell Carcinoma Depend on Tumor Grading.
Leonard Leifels, Sandra Purz, +5 authors, Alexey Surov.
Contrast Media Mol Imaging, 2017 Nov 09; 2017. PMID: 29114177    Free PMC article.
The effects of intravoxel contrast agent diffusion on the analysis of DCE-MRI data in realistic tissue domains.
Ryan T Woodall, Stephanie L Barnes, +3 authors, Thomas E Yankeelov.
Magn Reson Med, 2017 Nov 09; 80(1). PMID: 29115690    Free PMC article.
Functional evaluation of therapeutic response of HCC827 lung cancer to bevacizumab and erlotinib targeted therapy using dynamic contrast-enhanced and diffusion-weighted MRI.
Yi-Fang Chen, Ang Yuan, +4 authors, Yeun-Chung Chang.
PLoS One, 2017 Nov 10; 12(11). PMID: 29121075    Free PMC article.
Assessing treatment response in triple-negative breast cancer from quantitative image analysis in perfusion magnetic resonance imaging.
Imon Banerjee, Sadhika Malladi, +5 authors, Daniel L Rubin.
J Med Imaging (Bellingham), 2017 Nov 15; 5(1). PMID: 29134191    Free PMC article.
Dynamic Contrast-Enhanced MRI-Derived Intracellular Water Lifetime (τ ): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas.
S Chawla, L A Loevner, +7 authors, H Poptani.
AJNR Am J Neuroradiol, 2017 Nov 18; 39(1). PMID: 29146716    Free PMC article.
Linearization improves the repeatability of quantitative dynamic contrast-enhanced MRI.
Kyle M Jones, Mark D Pagel, Julio Cárdenas-Rodríguez.
Magn Reson Imaging, 2017 Nov 21; 47. PMID: 29155024    Free PMC article.
Quantitative Methods in Abdominal MRI: Perfusion Imaging.
Ananth J Madhuranthakam, Qing Yuan, Ivan Pedrosa.
Top Magn Reson Imaging, 2017 Nov 28; 26(6). PMID: 29176470    Free PMC article.
Detection of Treatment Success after Photodynamic Therapy Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Tom J L Schreurs, Igor Jacobs, +2 authors, Gustav J Strijkers.
Theranostics, 2017 Dec 01; 7(19). PMID: 29187893    Free PMC article.
Evaluation of B1 inhomogeneity effect on DCE-MRI data analysis of brain tumor patients at 3T.
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh.
J Transl Med, 2017 Dec 05; 15(1). PMID: 29197390    Free PMC article.
Robust and efficient pharmacokinetic parameter non-linear least squares estimation for dynamic contrast enhanced MRI of the prostate.
Soudabeh Kargar, Eric A Borisch, +5 authors, Stephen J Riederer.
Magn Reson Imaging, 2017 Dec 27; 48. PMID: 29278764    Free PMC article.
1.5 Tesla Magnetic Resonance Imaging to Investigate Potential Etiologies of Brain Swelling in Pediatric Cerebral Malaria.
Michael J Potchen, Samuel D Kampondeni, +11 authors, Gretchen L Birbeck.
Am J Trop Med Hyg, 2018 Jan 10; 98(2). PMID: 29313473    Free PMC article.
Renal Cell Carcinoma Perfusion before and after Radiofrequency Ablation Measured with Dynamic Contrast Enhanced MRI: A Pilot Study.
Tze Min Wah, Steven Sourbron, +4 authors, David L Buckley.
Diagnostics (Basel), 2018 Jan 11; 8(1). PMID: 29316711    Free PMC article.
Functional and molecular MRI of the bone marrow in multiple myeloma.
Vassilis Koutoulidis, Nickolas Papanikolaou, Lia A Moulopoulos.
Br J Radiol, 2018 Feb 03; 91(1088). PMID: 29393672    Free PMC article.
Adaptive Boost Target Definition in High-Risk Head and Neck Cancer Based on Multi-imaging Risk Biomarkers.
Feifei Teng, Madhava Aryal, +6 authors, Yue Cao.
Int J Radiat Oncol Biol Phys, 2018 Feb 13; 102(4). PMID: 29428251    Free PMC article.
Monitoring tumor response to the vascular disrupting agent CKD-516 in a rabbit VX2 intramuscular tumor model using PET/MRI: Simultaneous evaluation of vascular and metabolic parameters.
Su Yeon Ahn, Jin Mo Goo, +2 authors, Jin Chul Paeng.
PLoS One, 2018 Feb 14; 13(2). PMID: 29438381    Free PMC article.
Non-contrast MR imaging of blood-brain barrier permeability to water.
Zixuan Lin, Yang Li, +7 authors, Hanzhang Lu.
Magn Reson Med, 2018 Mar 03; 80(4). PMID: 29498097    Free PMC article.
Imaging in neuro-oncology.
Hari Nandu, Patrick Y Wen, Raymond Y Huang.
Ther Adv Neurol Disord, 2018 Mar 08; 11. PMID: 29511385    Free PMC article.
Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging.
Wen-Yen Chai, Po-Chun Chu, +4 authors, Hao-Li Liu.
Sci Rep, 2018 Mar 09; 8(1). PMID: 29515222    Free PMC article.
Variability in Quantitative DCE-MRI: Sources and Solutions.
Harrison Kim.
J Nat Sci, 2018 Mar 13; 4(1). PMID: 29527572    Free PMC article.
Blood perfusion of patellar bone measured by dynamic contrast-enhanced MRI in patients with patellofemoral pain: A case-control study.
Rianne A van der Heijden, Dirk H J Poot, +8 authors, Edwin H G Oei.
J Magn Reson Imaging, 2018 May 08; 48(5). PMID: 29734499    Free PMC article.
Impaired Cerebral Perfusion in Multiple Sclerosis: Relevance of Endothelial Factors.
Lucia Monti, Lucia Morbidelli, Alessandro Rossi.
Biomark Insights, 2018 May 26; 13. PMID: 29795976    Free PMC article.
Simultaneous PET/MRI in assessing the response to chemo/radiotherapy in head and neck carcinoma: initial experience.
Valeria Romeo, Brigida Iorio, +4 authors, Mario Covello.
Med Oncol, 2018 Jun 21; 35(7). PMID: 29922943
Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.
Jessie E Lee, Chris J Diederich, +7 authors, John Kurhanewicz.
NMR Biomed, 2018 Jul 20; 32(10). PMID: 30022550    Free PMC article.
Histogram Analysis of Perfusion Parameters from Dynamic Contrast-Enhanced MR Imaging with Tumor Characteristics and Therapeutic Response in Locally Advanced Rectal Cancer.
Dong Myung Yeo, Soon Nam Oh, +3 authors, Seung Eun Jung.
Biomed Res Int, 2018 Sep 07; 2018. PMID: 30186857    Free PMC article.
Multiparametric FDG-PET/MRI of Hepatocellular Carcinoma: Initial Experience.
Stefanie J Hectors, Mathilde Wagner, +2 authors, Bachir Taouli.
Contrast Media Mol Imaging, 2018 Nov 08; 2018. PMID: 30402045    Free PMC article.
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
K Ina Ly, Bella Vakulenko-Lagun, +12 authors, Elizabeth R Gerstner.
Sci Rep, 2018 Nov 22; 8(1). PMID: 30459364    Free PMC article.
Magnetic Resonance Imaging Parameters and Their Impact on Survival of Patients with Glioblastoma: Tumor Perfusion Predicts Survival.
Bob L Hou, Sijin Wen, +5 authors, Sanjay Bhatia.
World Neurosurg, 2018 Dec 30;. PMID: 30593971    Free PMC article.
3D nonrigid motion correction for quantitative assessment of hepatic lesions in DCE-MRI.
Matteo Ippoliti, Mathias Lukas, +3 authors, Christoph Kolbitsch.
Magn Reson Med, 2019 Jun 23; 82(5). PMID: 31228296    Free PMC article.
Dynamic contrast-enhanced MR imaging of the prostate: intraindividual comparison of gadoterate meglumine and gadobutrol.
Chau Hung Lee, Balamurugan Vellayappan, +2 authors, Patrick Asbach.
Eur Radiol, 2019 Jul 03; 29(12). PMID: 31264013
Reliability of dynamic contrast-enhanced magnetic resonance imaging data in primary brain tumours: a comparison of Tofts and shutter speed models.
Marianna Inglese, Katherine L Ordidge, +4 authors, Matthew Grech-Sollars.
Neuroradiology, 2019 Aug 09; 61(12). PMID: 31392385    Free PMC article.
Effect of Time Elapsed since Gadolinium Administration on Atherosclerotic Plaque Enhancement in Clinical Vessel Wall MR Imaging Studies.
A de Havenon, H J Muhina, +2 authors, M D Alexander.
AJNR Am J Neuroradiol, 2019 Sep 14; 40(10). PMID: 31515211    Free PMC article.
R2* Relaxation Affects Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI in Cancer and Underestimates Treatment Response at 7 T.
Jana Kim, Siver A Moestue, Tone F Bathen, Eugene Kim.
Tomography, 2019 Oct 02; 5(3). PMID: 31572792    Free PMC article.
Prognostic Predictions for Patients with Glioblastoma after Standard Treatment: Application of Contrast Leakage Information from DSC-MRI within Nonenhancing FLAIR High-Signal-Intensity Lesions.
S H Kim, K H Cho, +6 authors, S T Lee.
AJNR Am J Neuroradiol, 2019 Nov 16; 40(12). PMID: 31727756    Free PMC article.
Dynamic Contrast-Enhanced MR Imaging of Nonenhancing T2 High-Signal-Intensity Lesions in Baseline and Posttreatment Glioblastoma: Temporal Change and Prognostic Value.
I Hwang, S H Choi, +10 authors, C-H Sohn.
AJNR Am J Neuroradiol, 2019 Dec 07; 41(1). PMID: 31806595    Free PMC article.
Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure.
Dallan McMahon, Wendy Oakden, Kullervo Hynynen.
Theranostics, 2020 Feb 12; 10(4). PMID: 32042325    Free PMC article.
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging.
Henriette S de Bruijn, Vida Mashayekhi, +10 authors, Sabrina Oliveira.
Theranostics, 2020 Feb 25; 10(5). PMID: 32089747    Free PMC article.
Selection of Fitting Model and Arterial Input Function for Repeatability in Dynamic Contrast-Enhanced Prostate MRI.
Sharon Peled, Mark Vangel, +3 authors, Andrey Fedorov.
Acad Radiol, 2018 Nov 24; 26(9). PMID: 30467073    Free PMC article.
Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI.
Xingfeng Shao, Samantha J Ma, +3 authors, Danny J J Wang.
Magn Reson Med, 2018 Dec 19; 81(5). PMID: 30561821    Free PMC article.
Robust estimation of hemo-dynamic parameters in traditional DCE-MRI models.
Mikkel B Hansen, Anna Tietze, +4 authors, Kim Mouridsen.
PLoS One, 2019 Jan 04; 14(1). PMID: 30605459    Free PMC article.
Predicting clinically significant prostate cancer using DCE-MRI habitat descriptors.
N Andres Parra, Hong Lu, +12 authors, Yoganand Balagurunathan.
Oncotarget, 2019 Jan 17; 9(98). PMID: 30647849    Free PMC article.
The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma.
Xiang Xu, Jiadi Xu, +9 authors, Kannie W Y Chan.
Magn Reson Med, 2019 Feb 23; 81(6). PMID: 30793789    Free PMC article.
Habitats in DCE-MRI to Predict Clinically Significant Prostate Cancers.
Nestor Andres Parra, Hong Lu, +4 authors, Yoganand Balagurunathan.
Tomography, 2019 Mar 12; 5(1). PMID: 30854444    Free PMC article.
Early Prediction of Breast Cancer Therapy Response using Multiresolution Fractal Analysis of DCE-MRI Parametric Maps.
Archana Machireddy, Guillaume Thibault, +12 authors, Xubo Song.
Tomography, 2019 Mar 12; 5(1). PMID: 30854446    Free PMC article.
The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge, Part II.
Wei Huang, Yiyi Chen, +26 authors, Xin Li.
Tomography, 2019 Mar 12; 5(1). PMID: 30854447    Free PMC article.
Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.
Michael J Thrippleton, Walter H Backes, +9 authors, Joanna M Wardlaw.
Alzheimers Dement, 2019 Apr 30; 15(6). PMID: 31031101    Free PMC article.
Highly Cited. Review.
Optimal mass transport kinetic modeling for head and neck DCE-MRI: Initial analysis.
Rena Elkin, Saad Nadeem, +6 authors, Allen Tannenbaum.
Magn Reson Med, 2019 Jul 06; 82(6). PMID: 31273818    Free PMC article.
Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model.
Christopher Pham Pacia, Lifei Zhu, +6 authors, Hong Chen.
Sci Rep, 2020 May 06; 10(1). PMID: 32366915    Free PMC article.
Prognostic Value of Dynamic Contrast-Enhanced MRI-Derived Pharmacokinetic Variables in Glioblastoma Patients: Analysis of Contrast-Enhancing Lesions and Non-Enhancing T2 High-Signal Intensity Lesions.
Yeonah Kang, Eun Kyoung Hong, +7 authors, Seung Hong Choi.
Korean J Radiol, 2020 May 16; 21(6). PMID: 32410409    Free PMC article.
Quantitative DCE-MRI demonstrates increased blood perfusion in Hoffa's fat pad signal abnormalities in knee osteoarthritis, but not in patellofemoral pain.
Bas A de Vries, Rianne A van der Heijden, +4 authors, Edwin H G Oei.
Eur Radiol, 2020 Feb 18; 30(6). PMID: 32064564    Free PMC article.
Quantitative Imaging Informatics for Cancer Research.
Andrey Fedorov, Reinhard Beichel, +18 authors, Ron Kikinis.
JCO Clin Cancer Inform, 2020 May 12; 4. PMID: 32392097    Free PMC article.
Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity.
Caterina Brighi, Lee Reid, +8 authors, Simon Puttick.
Theranostics, 2020 Jun 03; 10(14). PMID: 32483457    Free PMC article.
Computational Modeling of Interstitial Fluid Pressure and Velocity in Non-small Cell Lung Cancer Brain Metastases Treated With Stereotactic Radiosurgery.
Nathaniel Swinburne, Eve LoCastro, +9 authors, Vaios Hatzoglou.
Front Neurol, 2020 Jun 18; 11. PMID: 32547470    Free PMC article.
Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
Ronel Veksler, Udi Vazana, +20 authors, Alon Friedman.
Brain, 2020 May 29; 143(6). PMID: 32464655    Free PMC article.
Magnetic resonance imaging based modeling of microvascular perfusion in patients with peripheral artery disease.
Olga A Gimnich, Jaykrishna Singh, +2 authors, Gerd Brunner.
J Biomech, 2019 Jul 25; 93. PMID: 31331663    Free PMC article.
The features of cerebral permeability and perfusion detected by dynamic contrast-enhanced magnetic resonance imaging with Patlak model in relapsing-remitting multiple sclerosis.
Hua Xiong, Ping Yin, +4 authors, Zhuoyue Tang.
Ther Clin Risk Manag, 2019 Feb 23; 15. PMID: 30787618    Free PMC article.
Integrated Multiparametric Radiomics and Informatics System for Characterizing Breast Tumor Characteristics with the OncotypeDX Gene Assay.
Michael A Jacobs, Christopher B Umbricht, +5 authors, Antonio C Wolff.
Cancers (Basel), 2020 Oct 01; 12(10). PMID: 32992569    Free PMC article.
Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study.
J E Park, J Y Kim, H S Kim, W H Shim.
AJNR Am J Neuroradiol, 2020 Oct 17; 41(11). PMID: 33060100    Free PMC article.
Differentiating the lymph node metastasis of breast cancer through dynamic contrast-enhanced magnetic resonance imaging.
Xu Dong, Yu Chunrong, Hou Hongjun, Zhang Xuexi.
BJR Open, 2019 May 14; 1(1). PMID: 33178917    Free PMC article.
Multi-parameter MRI to investigate vasculature modulation and photo-thermal ablation combination therapy against cancer.
Yesen Li, Jing Ye, +7 authors, Jin Xie.
Nanomedicine, 2018 Jul 27; 14(7). PMID: 30048816    Free PMC article.
Quantitative assessment of dynamic 18F-flumethycholine PET and dynamic contrast enhanced MRI in high risk prostate cancer.
Noam Tau, Alejandro Berlin, +5 authors, Ur Metser.
Br J Radiol, 2018 Nov 02; 92(1094). PMID: 30383459    Free PMC article.
Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans.
Linda Knutsson, Anina Seidemo, +8 authors, Xiang Xu.
Tomography, 2018 Dec 28; 4(4). PMID: 30588502    Free PMC article.
Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
Svetlana Lublinsky, Sebastian Major, +15 authors, Alon Friedman.
EBioMedicine, 2019 Jun 05; 43. PMID: 31162113    Free PMC article.
Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain.
Dallan McMahon, Anne Lassus, +2 authors, Kullervo Hynynen.
Sci Rep, 2020 Dec 11; 10(1). PMID: 33299094    Free PMC article.
Extended perfusion protocol for MS lesion quantification.
Eleftherios Kontopodis, Kostas Marias, +6 authors, Efrosini Papadaki.
Open Med (Wars), 2020 Dec 19; 15(1). PMID: 33336007    Free PMC article.
APRICOT: Advanced Platform for Reproducible Infrastructures in the Cloud via Open Tools.
Vicent Giménez-Alventosa, José Damián Segrelles, Germán Moltó, Mar Roca-Sogorb.
Methods Inf Med, 2020 Aug 11; 59(S 02). PMID: 32777825    Free PMC article.
Quantitative Magnetic Resonance Imaging of the Pancreas of Individuals With Diabetes.
John Virostko.
Front Endocrinol (Lausanne), 2020 Dec 22; 11. PMID: 33343509    Free PMC article.
Pharmacokinetic Analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging at 7T for Breast Cancer Diagnosis and Characterization.
R Elena Ochoa-Albiztegui, Varadan Sevilimedu, +6 authors, Katja Pinker.
Cancers (Basel), 2020 Dec 18; 12(12). PMID: 33327532    Free PMC article.
Quantitative volume and dynamic contrast-enhanced MRI derived perfusion of the infrapatellar fat pad in patellofemoral pain.
Rianne A van der Heijden, Bas A de Vries, +4 authors, Edwin H G Oei.
Quant Imaging Med Surg, 2021 Jan 05; 11(1). PMID: 33392017    Free PMC article.
Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.
Sarah Al-Bachari, Josephine H Naish, +2 authors, Laura M Parkes.
Front Physiol, 2021 Jan 09; 11. PMID: 33414722    Free PMC article.
Hyaluronidase reduced edema after experimental traumatic brain injury.
Patricia M Washington, Changhee Lee, +3 authors, Barclay Morrison.
J Cereb Blood Flow Metab, 2019 Oct 28; 40(10). PMID: 31648593    Free PMC article.
Evaluation of the influence of susceptibility-induced magnetic field distortions on the precision of contouring intracranial organs at risk for stereotactic radiosurgery.
Veit Mengling, Florian Putz, +5 authors, Christoph Bert.
Phys Imaging Radiat Oncol, 2021 Jan 19; 15. PMID: 33458332    Free PMC article.
Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.
Ko-Ting Chen, Wen-Yen Chai, +7 authors, Kuo-Chen Wei.
Sci Adv, 2021 Feb 07; 7(6). PMID: 33547073    Free PMC article.
Implementation of a dedicated 1.5 T MR scanner for radiotherapy treatment planning featuring a novel high-channel coil setup for brain imaging in treatment position.
Veit Mengling, Christoph Bert, +9 authors, Florian Putz.
Strahlenther Onkol, 2020 Oct 27; 197(3). PMID: 33103231