Journal Article
. 2010 Oct; 107(45):19396-401.
doi: 10.1073/pnas.1014515107.

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

Falk Nimmerjahn 1 Anja Lux  Heike Albert  Melissa Woigk  Christian Lehmann  Diana Dudziak  Patrick Smith  Jeffrey V Ravetch  
Affiliations
  • PMID: 20974962
  •     33 References
  •     76 citations

Abstract

Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.

A dominant role for mast cell Fc receptors in the Arthus reaction.
D L Sylvestre, J V Ravetch.
Immunity, 1996 Oct 01; 5(4). PMID: 8885871
Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.
Shahzad N Syed, Stephanie Konrad, +4 authors, J Engelbert Gessner.
Eur J Immunol, 2009 Oct 02; 39(12). PMID: 19795417
FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia.
D Meyer, C Schiller, +5 authors, J E Gessner.
Blood, 1998 Dec 03; 92(11). PMID: 9834201
Experimental antibody therapy of liver metastases reveals functional redundancy between Fc gammaRI and Fc gammaRIV.
Marielle A Otten, Gerben J van der Bij, +5 authors, Marjolein van Egmond.
J Immunol, 2008 Nov 05; 181(10). PMID: 18981101
Fcgamma receptors as regulators of immune responses.
Falk Nimmerjahn, Jeffrey V Ravetch.
Nat Rev Immunol, 2007 Dec 08; 8(1). PMID: 18064051
Highly Cited. Review.
IgEb immune complexes activate macrophages through FcgammaRIV binding.
Masayuki Hirano, Randall S Davis, +6 authors, Max D Cooper.
Nat Immunol, 2007 Jun 15; 8(7). PMID: 17558411
Antibody-mediated modulation of immune responses.
Falk Nimmerjahn, Jeffrey V Ravetch.
Immunol Rev, 2010 Jul 20; 236. PMID: 20636822
Highly Cited. Review.
Fc receptors are major mediators of antibody based inflammation in autoimmunity.
P Mark Hogarth.
Curr Opin Immunol, 2002 Nov 05; 14(6). PMID: 12413532
Review.
FcR gamma chain deletion results in pleiotrophic effector cell defects.
T Takai, M Li, +2 authors, J V Ravetch.
Cell, 1994 Feb 11; 76(3). PMID: 8313472
Highly Cited.
Reconstitution of human Fc gamma RIII cell type specificity in transgenic mice.
M Li, U Wirthmueller, J V Ravetch.
J Exp Med, 1996 Mar 01; 183(3). PMID: 8642269    Free PMC article.
Divergent immunoglobulin g subclass activity through selective Fc receptor binding.
Falk Nimmerjahn, Jeffrey V Ravetch.
Science, 2005 Dec 03; 310(5753). PMID: 16322460
Highly Cited.
Fc receptor but not complement binding is important in antibody protection against HIV.
Ann J Hessell, Lars Hangartner, +9 authors, Dennis R Burton.
Nature, 2007 Sep 07; 449(7158). PMID: 17805298
Highly Cited.
FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi, Jeffrey V Ravetch.
Immunity, 2005 Jul 26; 23(1). PMID: 16039578
Highly Cited.
Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors.
Yoshikatsu Kaneko, Falk Nimmerjahn, Michael P Madaio, Jeffrey V Ravetch.
J Exp Med, 2006 Mar 08; 203(3). PMID: 16520389    Free PMC article.
Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies.
Angela Giorgini, Heather J Brown, +5 authors, Michael G Robson.
J Immunol, 2008 Dec 04; 181(12). PMID: 19050295    Free PMC article.
Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice.
D Sylvestre, R Clynes, +3 authors, J V Ravetch.
J Exp Med, 1996 Dec 01; 184(6). PMID: 8976192    Free PMC article.
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation.
David A Mancardi, Bruno Iannascoli, +3 authors, Pierre Bruhns.
J Clin Invest, 2008 Oct 25; 118(11). PMID: 18949059    Free PMC article.
Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.
D Dombrowicz, V Flamand, +3 authors, J P Kinet.
J Clin Invest, 1997 Mar 01; 99(5). PMID: 9062349    Free PMC article.
Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype.
Wen-Kai Weng, Debra Czerwinski, +2 authors, Ronald Levy.
J Clin Oncol, 2004 Oct 16; 22(23). PMID: 15483014
Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.
Yasuhito Hamaguchi, Yan Xiu, +2 authors, Thomas F Tedder.
J Exp Med, 2006 Mar 08; 203(3). PMID: 16520392    Free PMC article.
Arthritis critically dependent on innate immune system players.
Hong Ji, Koichiro Ohmura, +16 authors, Diane Mathis.
Immunity, 2002 Mar 01; 16(2). PMID: 11869678
Highly Cited.
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma.
Wen-Kai Weng, Ronald Levy.
J Clin Oncol, 2003 Sep 17; 21(21). PMID: 12975461
Highly Cited.
Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.
L Fossati-Jimack, A Ioan-Facsinay, +10 authors, S Izui.
J Exp Med, 2000 Apr 19; 191(8). PMID: 10770797    Free PMC article.
Divergent roles for Fc receptors and complement in vivo.
J V Ravetch, R A Clynes.
Annu Rev Immunol, 1998 May 23; 16. PMID: 9597136
Review.
The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model.
S E McKenzie, S M Taylor, +7 authors, M P Reilly.
J Immunol, 1999 Apr 14; 162(7). PMID: 10201963
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene.
Guillaume Cartron, Laurent Dacheux, +4 authors, Hervé Watier.
Blood, 2002 Jan 25; 99(3). PMID: 11806974
Highly Cited.
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.
W L Hazenbos, J E Gessner, +9 authors, J S Verbeek.
Immunity, 1996 Aug 01; 5(2). PMID: 8769481
Highly Cited.
Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice.
Lucie Baudino, Falk Nimmerjahn, +6 authors, Shozo Izui.
J Immunol, 2008 Jan 23; 180(3). PMID: 18209093
Roles of Fc receptors in autoimmunity.
Toshiyuki Takai.
Nat Rev Immunol, 2002 Aug 03; 2(8). PMID: 12154377
Highly Cited. Review.
FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses.
Nadine Barnes, Amanda L Gavin, +3 authors, P Mark Hogarth.
Immunity, 2002 Mar 26; 16(3). PMID: 11911823
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.
D L Sylvestre, J V Ravetch.
Science, 1994 Aug 19; 265(5175). PMID: 8066448
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.
A Ioan-Facsinay, S J de Kimpe, +18 authors, J S Verbeek.
Immunity, 2002 Mar 26; 16(3). PMID: 11911824
Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor.
A Samuelsson, T L Towers, J V Ravetch.
Science, 2001 Feb 13; 291(5503). PMID: 11161202
Highly Cited.
Neutrophils give us a shock.
Clifford A Lowell.
J Clin Invest, 2011 Mar 26; 121(4). PMID: 21436575    Free PMC article.
Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.
Claudia Ferrara, Sandra Grau, +9 authors, Jörg Benz.
Proc Natl Acad Sci U S A, 2011 Jul 20; 108(31). PMID: 21768335    Free PMC article.
Highly Cited.
The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Sindhuja M Rao, Jennifer L Auger, +7 authors, Bryce A Binstadt.
Arthritis Res Ther, 2012 Feb 09; 14(1). PMID: 22314006    Free PMC article.
A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.
Maddalena Arigoni, Giuseppina Barutello, +8 authors, Federica Cavallo.
Angiogenesis, 2012 Mar 20; 15(2). PMID: 22426512    Free PMC article.
Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
Inessa Schwab, Falk Nimmerjahn.
Nat Rev Immunol, 2013 Feb 16; 13(3). PMID: 23411799
Highly Cited. Review.
Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines.
D Hannani, C Locher, +9 authors, L Zitvogel.
Cell Death Differ, 2013 Jun 08; 21(1). PMID: 23744294    Free PMC article.
Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.
Michaela Seeling, Ulrike Hillenhoff, +4 authors, Falk Nimmerjahn.
Proc Natl Acad Sci U S A, 2013 Jun 12; 110(26). PMID: 23754379    Free PMC article.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R Simpson, Fubin Li, +11 authors, Sergio A Quezada.
J Exp Med, 2013 Jul 31; 210(9). PMID: 23897981    Free PMC article.
Highly Cited.
Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica.
Julien Ratelade, Nithi Asavapanumas, +3 authors, A S Verkman.
Acta Neuropathol, 2013 Sep 03; 126(5). PMID: 23995423    Free PMC article.
Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo.
David J DiLillo, Gene S Tan, Peter Palese, Jeffrey V Ravetch.
Nat Med, 2014 Jan 15; 20(2). PMID: 24412922    Free PMC article.
Highly Cited.
Fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice.
Patricia M Hobday, Jennifer L Auger, +3 authors, Bryce A Binstadt.
Arthritis Rheumatol, 2014 Apr 24; 66(4). PMID: 24757138    Free PMC article.
Targeting B cells and autoantibodies in the therapy of autoimmune diseases.
Daniela Kao, Anja Lux, Inessa Schwab, Falk Nimmerjahn.
Semin Immunopathol, 2014 Apr 30; 36(3). PMID: 24777745
Review.
Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus: S. pyogenes super-infection.
Joshua M Klonoski, Heather R Hurtig, +9 authors, Victor C Huber.
Vaccine, 2014 Aug 01; 32(40). PMID: 25077423    Free PMC article.
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
Shiho Chiba, Hiroaki Ikushima, +9 authors, Tadatsugu Taniguchi.
Elife, 2014 Aug 26; 3. PMID: 25149452    Free PMC article.
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity.
Stylianos Bournazos, Florian Klein, +3 authors, Jeffrey V Ravetch.
Cell, 2014 Sep 13; 158(6). PMID: 25215485    Free PMC article.
Highly Cited.
Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.
Sang-oh Han, Songtao Li, +7 authors, Dwight Koeberl.
Hum Gene Ther, 2014 Nov 11; 26(1). PMID: 25382056    Free PMC article.
Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.
Kalani Halemano, Bradley S Barrett, +2 authors, Mario L Santiago.
J Virol, 2015 Jan 16; 89(7). PMID: 25589647    Free PMC article.
Requirement for innate immunity and CD90⁺ NK1.1⁻ lymphocytes to treat established melanoma with chemo-immunotherapy.
Marina Moskalenko, Michael Pan, +11 authors, Yvonne Saenger.
Cancer Immunol Res, 2015 Jan 21; 3(3). PMID: 25600438    Free PMC article.
Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages.
Hang Pong Ng, Xinmei Zhu, +2 authors, Shanmugam Nagarajan.
Arterioscler Thromb Vasc Biol, 2015 Mar 21; 35(5). PMID: 25792447    Free PMC article.
Immune complexes regulate bone metabolism through FcRγ signalling.
Takako Negishi-Koga, Hans-Jürgen Gober, +8 authors, Hiroshi Takayanagi.
Nat Commun, 2015 Apr 01; 6. PMID: 25824719
Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect.
David J DiLillo, Jeffrey V Ravetch.
Cell, 2015 May 16; 161(5). PMID: 25976835    Free PMC article.
Highly Cited.
Unlocking the bone: Fcγ-receptors and antibody glycosylation are keys to connecting bone homeostasis to humoral immunity.
Michaela Seeling, Falk Nimmerjahn.
Ann Transl Med, 2015 Aug 12; 3(12). PMID: 26261834    Free PMC article.
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.
SunAh Kang, Amanda B Keener, +7 authors, Barbara J Vilen.
J Immunol, 2015 Dec 02; 196(1). PMID: 26621863    Free PMC article.
Human IgG1 antibodies suppress angiogenesis in a target-independent manner.
Sasha Bogdanovich, Younghee Kim, +33 authors, Jayakrishna Ambati.
Signal Transduct Target Ther, 2016 Feb 27; 1. PMID: 26918197    Free PMC article.
IgG subclasses determine pathways of anaphylaxis in mice.
Héloïse Beutier, Caitlin M Gillis, +10 authors, Friederike Jönsson.
J Allergy Clin Immunol, 2016 Jun 02; 139(1). PMID: 27246523    Free PMC article.
Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.
Efstathios G Stamatiades, Marie-Eve Tremblay, +11 authors, Frederic Geissmann.
Cell, 2016 Aug 02; 166(4). PMID: 27477514    Free PMC article.
Highly Cited.
Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity.
Fernando Souza-Fonseca-Guimaraes, Stephen J Blake, +3 authors, Mark J Smyth.
Oncoimmunology, 2016 Sep 14; 5(7). PMID: 27622048    Free PMC article.
CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.
Wei Hseun Yeap, Kok Loon Wong, +7 authors, Siew Cheng Wong.
Sci Rep, 2016 Sep 28; 6. PMID: 27670158    Free PMC article.
Highly Cited.
Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.
Silvie Van den Hoecke, Katrin Ehrhardt, +14 authors, Xavier Saelens.
J Virol, 2017 Jan 13; 91(7). PMID: 28077656    Free PMC article.
Highly Cited.
The Role and Function of Fcγ Receptors on Myeloid Cells.
Stylianos Bournazos, Taia T Wang, Jeffrey V Ravetch.
Microbiol Spectr, 2017 Jan 15; 4(6). PMID: 28087938    Free PMC article.
Review.
Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.
Priyanka Chauhan, Shuxian Hu, +2 authors, James R Lokensgard.
Sci Rep, 2017 Feb 07; 7. PMID: 28165503    Free PMC article.
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H K Lehmann, Anna Baranska, +15 authors, Diana Dudziak.
J Exp Med, 2017 Apr 09; 214(5). PMID: 28389502    Free PMC article.
Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.
Bradley S Barrett, Michael S Harper, +5 authors, Mario L Santiago.
Retrovirology, 2017 Apr 19; 14(1). PMID: 28415995    Free PMC article.
Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases.
Dipti Vijayan, Deborah S Barkauskas, +7 authors, Mark J Smyth.
Oncoimmunology, 2017 Jun 24; 6(5). PMID: 28638737    Free PMC article.
A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza.
Tor Kristian Andersen, Fan Zhou, +2 authors, Gunnveig Grødeland.
J Virol, 2017 Sep 22; 91(23). PMID: 28931687    Free PMC article.
Pathological expression of tissue factor confers promising antitumor response to a novel therapeutic antibody SC1 in triple negative breast cancer and pancreatic adenocarcinoma.
Xuesai Zhang, Qingrou Li, +6 authors, Ker Yu.
Oncotarget, 2017 Sep 25; 8(35). PMID: 28938620    Free PMC article.
Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood.
Jung-Rok Lee, Carmel T Chan, +7 authors, Shan X Wang.
Nano Lett, 2017 Oct 11; 17(11). PMID: 28990786    Free PMC article.
Combining intratumoral Treg depletion with androgen deprivation therapy (ADT): preclinical activity in the Myc-CaP model.
Ying-Chun Shen, Ali Ghasemzadeh, +9 authors, Charles G Drake.
Prostate Cancer Prostatic Dis, 2017 Dec 06; 21(1). PMID: 29203894    Free PMC article.
Phasor-Based Endogenous NAD(P)H Fluorescence Lifetime Imaging Unravels Specific Enzymatic Activity of Neutrophil Granulocytes Preceding NETosis.
Ruth Leben, Lennard Ostendorf, +4 authors, Raluca A Niesner.
Int J Mol Sci, 2018 Mar 30; 19(4). PMID: 29596303    Free PMC article.
Artificial Anti-Tumor Opsonizing Proteins with Fibronectin Scaffolds Engineered for Specificity to Each of the Murine FcγR Types.
Tiffany F Chen, Kevin K Li, +5 authors, K Dane Wittrup.
J Mol Biol, 2018 Apr 29; 430(12). PMID: 29704491    Free PMC article.
FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines.
Hreinn Benonisson, Heng Sheng Sow, +9 authors, Sjef Verbeek.
Oncotarget, 2018 Jul 24; 9(50). PMID: 30034625    Free PMC article.
Non-neutralizing antibodies elicited by recombinant Lassa-Rabies vaccine are critical for protection against Lassa fever.
Tiago Abreu-Mota, Katie R Hagen, +5 authors, Matthias J Schnell.
Nat Commun, 2018 Oct 13; 9(1). PMID: 30310067    Free PMC article.
IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages.
Meili Zhang, Bernard Wen, +8 authors, Thomas A Waldmann.
Proc Natl Acad Sci U S A, 2018 Oct 31; 115(46). PMID: 30373815    Free PMC article.
NK Cell-Fc Receptors Advance Tumor Immunotherapy.
Emilio Sanseviero.
J Clin Med, 2019 Oct 17; 8(10). PMID: 31614774    Free PMC article.
Review.
Rational Design and In Vivo Characterization of Vaccine Adjuvants.
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Dennis Christensen.
ILAR J, 2019 Jan 10; 59(3). PMID: 30624655    Free PMC article.
Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection.
Dorien De Vlieger, Katja Hoffmann, +8 authors, Xavier Saelens.
Front Immunol, 2020 Jan 11; 10. PMID: 31921179    Free PMC article.
CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis.
Li-Chung Tsao, Erika J Crosby, +14 authors, Zachary C Hartman.
JCI Insight, 2019 Nov 07; 4(24). PMID: 31689243    Free PMC article.
Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin.
Patrizia Murer, Jonathan D Kiefer, +4 authors, Dario Neri.
J Invest Dermatol, 2018 Dec 14; 139(6). PMID: 30543899    Free PMC article.
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Patrick J Engelberts, Ida H Hiemstra, +13 authors, Esther C W Breij.
EBioMedicine, 2020 Jan 26; 52. PMID: 31981978    Free PMC article.
There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes.
Christina Kerntke, Falk Nimmerjahn, Markus Biburger.
Front Immunol, 2020 Mar 03; 11. PMID: 32117269    Free PMC article.
B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses.
Jayashree Bagchi-Chakraborty, Anna Francis, +12 authors, Andrew P Sage.
Arterioscler Thromb Vasc Biol, 2019 May 17; 39(7). PMID: 31092015    Free PMC article.
Bone Marrow-Derived and Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate the Cell Type Used.
Cheryl M Zajd, Alexis M Ziemba, +5 authors, Michelle R Lennartz.
Front Immunol, 2020 Mar 11; 11. PMID: 32153579    Free PMC article.
Programming Isotype-Specific Plasma Cell Function.
Brett W Higgins, Louise J McHeyzer-Williams, Michael G McHeyzer-Williams.
Trends Immunol, 2019 Mar 09; 40(4). PMID: 30846256    Free PMC article.
Review.
FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy.
Xin Chen, Xiaomin Song, Kang Li, Tong Zhang.
Front Immunol, 2019 Mar 14; 10. PMID: 30863404    Free PMC article.
Highly Cited. Review.
Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses.
Demo Yemane Tesfaye, Arnar Gudjonsson, Bjarne Bogen, Even Fossum.
Front Immunol, 2019 Jul 25; 10. PMID: 31333661    Free PMC article.
Review.
Antibodies targeting sialyl Lewis A mediate tumor clearance through distinct effector pathways.
Polina Weitzenfeld, Stylianos Bournazos, Jeffrey V Ravetch.
J Clin Invest, 2019 Aug 20; 129(9). PMID: 31424423    Free PMC article.
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Alex Bersellini Farinotti, Gustaf Wigerblad, +28 authors, Camilla I Svensson.
J Exp Med, 2019 Jun 15; 216(8). PMID: 31196979    Free PMC article.
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.
Xiaojie Yu, H T Claude Chan, +13 authors, Mark S Cragg.
Cancer Cell, 2020 May 23; 37(6). PMID: 32442402    Free PMC article.
A Single-Cycle Glycoprotein D Deletion Viral Vaccine Candidate, ΔgD-2, Elicits Polyfunctional Antibodies That Protect against Ocular Herpes Simplex Virus.
Natalie L M Ramsey, Maria Visciano, +4 authors, Betsy C Herold.
J Virol, 2020 Apr 17; 94(13). PMID: 32295919    Free PMC article.
Fcγ receptor pathways during active and passive immunization.
Stylianos Bournazos, Jeffrey V Ravetch.
Immunol Rev, 2015 Oct 27; 268(1). PMID: 26497515    Free PMC article.
Review.
HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses.
Clare Burn Aschner, Lip Nam Loh, +8 authors, Betsy C Herold.
Sci Immunol, 2020 Aug 21; 5(50). PMID: 32817296    Free PMC article.
Intradermal Delivery of Dendritic Cell-Targeting Chimeric mAbs Genetically Fused to Type 2 Dengue Virus Nonstructural Protein 1.
Lennon Ramos Pereira, Elaine Cristina Matos Vicentin, +11 authors, Luís Carlos de Souza Ferreira.
Vaccines (Basel), 2020 Oct 07; 8(4). PMID: 33019498    Free PMC article.
CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help.
Stephan Klessing, Vladimir Temchura, +4 authors, Klaus Überla.
Vaccines (Basel), 2020 Oct 18; 8(4). PMID: 33066267    Free PMC article.
Existence of natural mouse IgG mAbs recognising epitopes shared by malondialdehyde acetaldehyde adducts and Porphyromonas gingivalis.
Mikael Kyrklund, Heidi Kaski, +6 authors, Chunguang Wang.
Innate Immun, 2021 Jan 16; 27(2). PMID: 33445998    Free PMC article.
Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice.
Byong H Kang, Noor Momin, +4 authors, K Dane Wittrup.
PLoS One, 2021 Apr 16; 16(4). PMID: 33857179    Free PMC article.
Differential and sequential immunomodulatory role of neutrophils and Ly6Chi inflammatory monocytes during antiviral antibody therapy.
Jennifer Lambour, Mar Naranjo-Gomez, Myriam Boyer-Clavel, Mireia Pelegrin.
Emerg Microbes Infect, 2021 Apr 17; 10(1). PMID: 33858301    Free PMC article.
Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections.
Shamus P Keeler, Julie M Fox.
Viruses, 2021 Jun 03; 13(6). PMID: 34072720    Free PMC article.
Review.
Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis.
Yuyue Zuo, Guo-Min Deng.
Front Immunol, 2021 Jul 13; 12. PMID: 34248975    Free PMC article.
Systematic Review.
Cross-species higher sensitivities of FcγRIIIA/FcγRIV to afucosylated IgG for enhanced ADCC.
Changchuin Mao, Richard Near, Xuemei Zhong, Wenda Gao.
Antib Ther, 2021 Sep 07; 4(3). PMID: 34485821    Free PMC article.
A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.
Katherine Kaugars, Joseph Dardick, +10 authors, William R Jacobs.
Proc Natl Acad Sci U S A, 2021 Aug 22; 118(34). PMID: 34417304    Free PMC article.
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.
Bo Xu, Lei Tian, +10 authors, Jianhua Yu.
Nat Commun, 2021 Oct 10; 12(1). PMID: 34625564    Free PMC article.
Tyrosine-Based Cross-Linking of Peptide Antigens to Generate Nanoclusters with Enhanced Immunogenicity: Demonstration Using the Conserved M2e Peptide of Influenza A.
Logan R Wilks, Gaurav Joshi, Megan R Grisham, Harvinder Singh Gill.
ACS Infect Dis, 2021 Aug 26; 7(9). PMID: 34432416    Free PMC article.
Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages.
Caroline Gravel, Abenaya Muralidharan, +16 authors, Xuguang Li.
iScience, 2021 Nov 23; 24(11). PMID: 34805790    Free PMC article.
Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant.
Yucheol Cheong, Minjin Kim, +9 authors, Baik Lin Seong.
Front Immunol, 2021 Dec 07; 12. PMID: 34868027    Free PMC article.
A Host-Restricted Self-Attenuated Influenza Virus Provides Broad Pan-Influenza A Protection in a Mouse Model.
Minjin Kim, Yucheol Cheong, +4 authors, Baik Lin Seong.
Front Immunol, 2021 Dec 21; 12. PMID: 34925355    Free PMC article.
SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
BradleyS Barrett, David H Nguyen, +10 authors, Mario L Santiago.
J Immunol, 2021 Dec 12; 208(2). PMID: 34893529    Free PMC article.