Journal Article
. 2010 Oct; 107(45):19396-401.
doi: 10.1073/pnas.1014515107.

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

Falk Nimmerjahn 1 Anja Lux  Heike Albert  Melissa Woigk  Christian Lehmann  Diana Dudziak  Patrick Smith  Jeffrey V Ravetch  
  • PMID: 20974962
  •     33 References
  •     76 citations


Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.

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Front Immunol, 2021 Dec 21; 12. PMID: 34925355    Free PMC article.
SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide.
BradleyS Barrett, David H Nguyen, +10 authors, Mario L Santiago.
J Immunol, 2021 Dec 12; 208(2). PMID: 34893529    Free PMC article.