Systems biology and genomics of breast cancer

Charles M Perou ¹, Anne-Lise Børresen-Dale

Affiliations

¹ Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. cperou@med.unc.edu

PMID: 21047916
101 References
69 citations

Abstract

It is now accepted that breast cancer is not a single disease, but instead it is composed of a spectrum of tumor subtypes with distinct cellular origins, somatic changes, and etiologies. Gene expression profiling using DNA microarrays has contributed significantly to our understanding of the molecular heterogeneity of breast tumor formation, progression, and recurrence. For example, at least two clinical diagnostic assays exist (i.e., OncotypeDX RS and Mammaprint®) that are able to predict outcome in patients using patterns of gene expression and predetermined mathematical algorithms. In addition, a new molecular taxonomy based upon the inherent, or "intrinsic," biology of breast tumors has been developed; this taxonomy is called the "intrinsic subtypes of breast cancer," which now identifies five distinct tumor types and a normal breast-like group. Importantly, the intrinsic subtypes of breast cancer predict patient relapse, overall survival, and response to endocrine and chemotherapy regimens. Thus, most of the clinical behavior of a breast tumor is already written in its subtype profile. Here, we describe the discovery and basic biology of the intrinsic subtypes of breast cancer, and detail how this interacts with underlying genetic alternations, response to therapy, and the metastatic process.

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HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases. Gabriela Paroni, Marco Bolis, +8 authors, Enrico Garattini. less Oncogene, 2018 Dec 13; 38(15). PMID: 30538297
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Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers. Nader N El-Chaar, Thomas E Smith, +8 authors, Philip J Moos. less Mar Drugs, 2021 Jan 23; 19(1). PMID: 33477536 Free PMC article.
Targeting the purinergic pathway in breast cancer and its therapeutic applications. Julia Beatrice de Araújo, Vanessa Vitória Kerkhoff, Sarah Franco Vieira de Oliveira Maciel, Débora Tavares de Resende E Silva. Purinergic Signal, 2021 Feb 13;. PMID: 33576905 Free PMC article. Review.

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