Review
. 2010 Dec;5(1).
doi: 10.1016/j.molonc.2010.11.003.

Deconstructing the molecular portraits of breast cancer

Aleix Prat 1 Charles M Perou  
Affiliations
  • PMID: 21147047
  •     101 References
  •     457 citations

Abstract

Breast cancer is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites, and patient outcomes. Global gene expression analyses using high-throughput technologies have helped to explain much of this heterogeneity and provided important new classifications of cancer patients. In the last decade, genomic studies have established five breast cancer intrinsic subtypes (Luminal A, Luminal B, HER2-enriched, Claudin-low, Basal-like) and a Normal Breast-like group. In this review, we dissect the most recent data on this genomic classification of breast cancer with a special focus on the Claudin-low subtype, which appears enriched for mesenchymal and stem cell features. In addition, we discuss how the combination of standard clinical-pathological markers with the information provided by these genomic entities might help further understand the biological complexity of this disease, increase the efficacy of current and novel therapies, and ultimately improve outcomes for breast cancer patients.

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Ann Oncol, 2011 Jun 29; 22(8). PMID: 21709140    Free PMC article.
Highly Cited.
Management options in triple-negative breast cancer.
Christina A Minami, Debra U Chung, Helena R Chang.
Breast Cancer (Auckl), 2011 Aug 25; 5. PMID: 21863131    Free PMC article.
Breast cancer subtype-specific interactions with the microenvironment dictate mechanisms of invasion.
Tuyen T Dang, Amanda M Prechtl, Gray W Pearson.
Cancer Res, 2011 Sep 13; 71(21). PMID: 21908556    Free PMC article.
DNA damage and breast cancer.
Jennifer D Davis, Shiaw-Yih Lin.
World J Clin Oncol, 2011 Sep 13; 2(9). PMID: 21909479    Free PMC article.
Epidemiology of triple negative breast cancers.
Gretchen L Gierach, Aileen Burke, William F Anderson.
Breast Dis, 2011 Oct 04; 32(1-2). PMID: 21965309    Free PMC article.
Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer.
Abderrahim El Guerrab, Rabah Zegrour, +5 authors, Yves-Jean Bignon.
PLoS One, 2011 Oct 04; 6(9). PMID: 21966417    Free PMC article.
The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.
Archana Dhasarathy, Dhiral Phadke, +2 authors, Paul A Wade.
PLoS One, 2011 Oct 27; 6(10). PMID: 22028892    Free PMC article.
Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases.
Barbara Adamo, Allison M Deal, +11 authors, Carey K Anders.
Breast Cancer Res, 2011 Dec 03; 13(6). PMID: 22132754    Free PMC article.
Invasive Breast Cancer: Recognition of Molecular Subtypes.
Johanna D Strehl, David L Wachter, +2 authors, Arndt Hartmann.
Breast Care (Basel), 2011 Dec 03; 6(4). PMID: 22135623    Free PMC article.
Practical implications of gene-expression-based assays for breast oncologists.
Aleix Prat, Matthew J Ellis, Charles M Perou.
Nat Rev Clin Oncol, 2011 Dec 07; 9(1). PMID: 22143140    Free PMC article.
Highly Cited. Review.
Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.
Shreya Mitra, Katherine Stemke-Hale, Gordon B Mills, Sofie Claerhout.
Cancer Sci, 2011 Dec 14; 103(3). PMID: 22151725    Free PMC article.
Review.
Expression of tight junction molecules in breast carcinomas analysed by array PCR and immunohistochemistry.
Anna-Mária Tőkés, Attila Marcell Szász, +8 authors, Janina Kulka.
Pathol Oncol Res, 2011 Dec 24; 18(3). PMID: 22193974
Identification of aberrant pathways and network activities from high-throughput data.
Jinlian Wang, Yuji Zhang, Catalin Marian, Habtom W Ressom.
Brief Bioinform, 2012 Jan 31; 13(4). PMID: 22287794    Free PMC article.
Review.
Translating cancer 'omics' to improved outcomes.
Emily A Vucic, Kelsie L Thu, +4 authors, Wan L Lam.
Genome Res, 2012 Feb 04; 22(2). PMID: 22301133    Free PMC article.
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Benjamin T Spike, Dannielle D Engle, +3 authors, Geoffrey M Wahl.
Cell Stem Cell, 2012 Feb 07; 10(2). PMID: 22305568    Free PMC article.
Highly Cited.
Is there any role for new prognostic markers in breast cancer?
Agustí Barnadas.
Clin Transl Oncol, 2012 Mar 01; 14(3). PMID: 22374417
Review.
Neoadjuvant Therapy - What Have We Achieved in the Last 20 Years?
Jens Huober, Gunter von Minckwitz.
Breast Care (Basel), 2012 Mar 16; 6(6). PMID: 22419894    Free PMC article.
Omics and therapy - a basis for precision medicine.
Joseph P Garay, Joe W Gray.
Mol Oncol, 2012 Mar 27; 6(2). PMID: 22445068    Free PMC article.
Review.
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
Cynthia X Ma, Shirong Cai, +10 authors, Helen Piwnica-Worms.
J Clin Invest, 2012 Mar 27; 122(4). PMID: 22446188    Free PMC article.
Highly Cited.
Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer.
Miguel Martín, Anatoly Makhson, +6 authors, Sergei Tjulandin.
Oncologist, 2012 Apr 03; 17(4). PMID: 22467666    Free PMC article.
DNA methylation signatures for breast cancer classification and prognosis.
Moshe Szyf.
Genome Med, 2012 Apr 13; 4(3). PMID: 22494847    Free PMC article.
Review.
Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen.
A Prat, J S Parker, +9 authors, C M Perou.
Ann Oncol, 2012 Apr 26; 23(11). PMID: 22532584    Free PMC article.
Tumor heterogeneity and its implication for drug delivery.
Tracy A Denison, You Han Bae.
J Control Release, 2012 Apr 28; 164(2). PMID: 22537887    Free PMC article.
Review.
Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.
Jessica E Hutti, Adam D Pfefferle, +3 authors, Albert S Baldwin.
Cancer Res, 2012 May 04; 72(13). PMID: 22552288    Free PMC article.
Estrogen-related receptor alpha: an orphan finds a family.
Aleksandra M Ochnik, Douglas Yee.
Breast Cancer Res, 2012 May 12; 14(3). PMID: 22574877    Free PMC article.
To differentiate or not--routes towards metastasis.
Thomas Brabletz.
Nat Rev Cancer, 2012 May 12; 12(6). PMID: 22576165
Highly Cited. Review.
Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
Claudia Piovan, Dario Palmieri, +11 authors, Carlo M Croce.
Mol Oncol, 2012 May 15; 6(4). PMID: 22578566    Free PMC article.
The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
Steven T Sizemore, Ruth A Keri.
J Biol Chem, 2012 May 31; 287(29). PMID: 22645147    Free PMC article.
Molecular oncology: The positive in the negative.
Kendall Powell.
Nature, 2012 Jun 01; 485(7400). PMID: 22648498
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Anne-Pierre Morel, George W Hinkal, +14 authors, Alain Puisieux.
PLoS Genet, 2012 Jun 02; 8(5). PMID: 22654675    Free PMC article.
TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer.
Lisa A Carey, Hope S Rugo, +17 authors, Eric P Winer.
J Clin Oncol, 2012 Jun 06; 30(21). PMID: 22665533    Free PMC article.
Highly Cited.
At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone.
John Foley, Nicole Nickerson, +3 authors, Anne M Foley.
Odontology, 2012 Jun 12; 100(2). PMID: 22684584    Free PMC article.
Review.
Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression.
Todd P Knutson, Andrea R Daniel, +4 authors, Carol A Lange.
Breast Cancer Res, 2012 Jun 16; 14(3). PMID: 22697792    Free PMC article.
A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.
Byong Hoon Yoo, Sunshine Daddario Axlund, +4 authors, Daniel V LaBarbera.
J Biomol Screen, 2012 Jul 04; 17(9). PMID: 22751729    Free PMC article.
PAM50 assay and the three-gene model for identifying the major and clinically relevant molecular subtypes of breast cancer.
A Prat, J S Parker, C Fan, C M Perou.
Breast Cancer Res Treat, 2012 Jul 04; 135(1). PMID: 22752290    Free PMC article.
ER and PR signaling nodes during mammary gland development.
Tamara Tanos, Lucia Rojo, Pablo Echeverria, Cathrin Brisken.
Breast Cancer Res, 2012 Jul 20; 14(4). PMID: 22809143    Free PMC article.
Review.
High-risk estrogen-receptor-positive breast cancer: identification and implications for therapy.
Rosemary L Balleine, Nicholas R Wilcken.
Mol Diagn Ther, 2012 Jul 21; 16(4). PMID: 22812573
Review.
Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures.
Peter Kabos, Jessica Finlay-Schultz, +8 authors, Carol A Sartorius.
Breast Cancer Res Treat, 2012 Jul 24; 135(2). PMID: 22821401    Free PMC article.
Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice.
María Paula Roberti, Juan Martín Arriaga, +5 authors, María Marcela Barrio.
Cancer Biol Ther, 2012 Jul 25; 13(11). PMID: 22825326    Free PMC article.
MicroRNAs in breast cancer initiation and progression.
Huiping Liu.
Cell Mol Life Sci, 2012 Aug 29; 69(21). PMID: 22926415    Free PMC article.
Review.
The molecular profile of luminal B breast cancer.
Chad J Creighton.
Biologics, 2012 Sep 08; 6. PMID: 22956860    Free PMC article.
Human epidermal growth factor receptor-2-positive breast cancer: does estrogen receptor status define two distinct subtypes?
I Vaz-Luis, E P Winer, N U Lin.
Ann Oncol, 2012 Oct 02; 24(2). PMID: 23022997    Free PMC article.
Review.
Impact of hormone receptor status on patterns of recurrence and clinical outcomes among patients with human epidermal growth factor-2-positive breast cancer in the National Comprehensive Cancer Network: a prospective cohort study.
Ines Vaz-Luis, Rebecca A Ottesen, +8 authors, Nancy U Lin.
Breast Cancer Res, 2012 Oct 03; 14(5). PMID: 23025714    Free PMC article.
Detection of disseminated tumor cells in the bone marrow of breast cancer patients using multiplex gene expression measurements identifies new therapeutic targets in patients at high risk for the development of metastatic disease.
Chidananda M Siddappa, Mark A Watson, +3 authors, Rebecca Aft.
Breast Cancer Res Treat, 2012 Nov 07; 137(1). PMID: 23129172    Free PMC article.
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.
Francesca Di Modugno, Pierluigi Iapicca, +7 authors, Paola Nisticò.
Proc Natl Acad Sci U S A, 2012 Nov 07; 109(47). PMID: 23129656    Free PMC article.
ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR.
Christoforos Thomas, Gayani Rajapaksa, +9 authors, Jan-Åke Gustafsson.
Breast Cancer Res, 2012 Nov 20; 14(6). PMID: 23158001    Free PMC article.
Rab25 in cancer: a brief update.
Shreya Mitra, Kwai W Cheng, Gordon B Mills.
Biochem Soc Trans, 2012 Nov 28; 40(6). PMID: 23176489    Free PMC article.
Review.
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion.
Jessica Bockhorn, Kathy Yee, +11 authors, Huiping Liu.
Breast Cancer Res Treat, 2012 Dec 12; 137(2). PMID: 23224145    Free PMC article.
Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.
Aleix Prat, Maggie Chon U Cheang, +8 authors, Charles M Perou.
J Clin Oncol, 2012 Dec 13; 31(2). PMID: 23233704    Free PMC article.
Highly Cited.
PTP1B expression is an independent positive prognostic factor in human breast cancer.
S Soysal, E C Obermann, +4 authors, S Muenst.
Breast Cancer Res Treat, 2012 Dec 18; 137(2). PMID: 23242616    Free PMC article.
Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade.
Leisha A Emens.
Expert Rev Anticancer Ther, 2012 Dec 21; 12(12). PMID: 23253225    Free PMC article.
Review.
Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin).
Begoña Martin-Castillo, Cristina Oliveras-Ferraros, +7 authors, Javier A Menendez.
Cell Cycle, 2012 Dec 21; 12(2). PMID: 23255137    Free PMC article.
Analysis of pattern, time and risk factors influencing recurrence in triple-negative breast cancer patients.
Katarzyna Pogoda, Anna Niwińska, Magdalena Murawska, Tadeusz Pieńkowski.
Med Oncol, 2013 Jan 08; 30(1). PMID: 23292831    Free PMC article.
Gene signatures in breast cancer: current and future uses.
Enrique Espinosa Arranz, Juan Ángel Fresno Vara, Angelo Gámez-Pozo, Pilar Zamora.
Transl Oncol, 2013 Jan 17; 5(6). PMID: 23323153    Free PMC article.
Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice.
S Ke, W Wang, +10 authors, M Li.
Curr Mol Med, 2013 Jan 22; 13(3). PMID: 23331017    Free PMC article.
Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential.
Goar Mosoyan, Chandandeep Nagi, +8 authors, Arevik Mosoian.
PLoS One, 2013 Feb 02; 8(1). PMID: 23372829    Free PMC article.
Molecular characterization of basal-like and non-basal-like triple-negative breast cancer.
Aleix Prat, Barbara Adamo, +3 authors, Charles M Perou.
Oncologist, 2013 Feb 14; 18(2). PMID: 23404817    Free PMC article.
Highly Cited. Review.
Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells.
M F Kendellen, J W Bradford, +2 authors, A S Baldwin.
Oncogene, 2013 Mar 12; 33(10). PMID: 23474754    Free PMC article.
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.
Stina Mui Singel, Crystal Cornelius, +4 authors, Jerry W Shay.
Clin Cancer Res, 2013 Mar 13; 19(8). PMID: 23479679    Free PMC article.
Quantitative molecular analysis of sentinel lymph node may be predictive of axillary node status in breast cancer classified by molecular subtypes.
Simonetta Buglioni, Franco Di Filippo, +9 authors, Marcella Mottolese.
PLoS One, 2013 Mar 28; 8(3). PMID: 23533593    Free PMC article.
STAT signaling in different breast cancer sub-types.
Priscilla A Furth.
Mol Cell Endocrinol, 2013 Apr 09; 382(1). PMID: 23562422    Free PMC article.
Review.
Molecular subtypes of breast cancer: metabolic correlation with ¹⁸F-FDG PET/CT.
Ana María García Vicente, Ángel Soriano Castrejón, +6 authors, Ana González Ageitos.
Eur J Nucl Med Mol Imaging, 2013 May 02; 40(9). PMID: 23632960
A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.
Xiaomei Zhang, Sofie Claerhout, +26 authors, Michael T Lewis.
Cancer Res, 2013 Jun 06; 73(15). PMID: 23737486    Free PMC article.
Highly Cited.
The Marker State Space (MSS) method for classifying clinical samples.
Brian P Fallon, Bryan Curnutte, +6 authors, Brian B Haab.
PLoS One, 2013 Jun 12; 8(6). PMID: 23750276    Free PMC article.
The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer.
S Muenst, S D Soysal, +3 authors, W E Gillanders.
Breast Cancer Res Treat, 2013 Jun 13; 139(3). PMID: 23756627    Free PMC article.
Highly Cited.
Clinicopathologic, mammographic, and sonographic features in 1,187 patients with pure ductal carcinoma in situ of the breast by estrogen receptor status.
Gaiane M Rauch, Henry M Kuerer, +8 authors, Wei T Yang.
Breast Cancer Res Treat, 2013 Jun 19; 139(3). PMID: 23774990    Free PMC article.
Clinicopathological features among patients with advanced human epidermal growth factor-2-positive breast cancer with prolonged clinical benefit to first-line trastuzumab-based therapy: a retrospective cohort study.
Ines Vaz-Luis, Davinia Seah, +8 authors, Nancy U Lin.
Clin Breast Cancer, 2013 Jul 09; 13(4). PMID: 23829891    Free PMC article.
Using large-scale molecular data sets to improve breast cancer treatment.
Chad J Creighton.
Breast Cancer Manag, 2012 May 01; 1(1). PMID: 23869198    Free PMC article.
Patterns of Recurrence and outcome according to breast cancer subtypes in lymph node-negative disease: results from international breast cancer study group trials VIII and IX.
Otto Metzger-Filho, Zhuoxin Sun, +8 authors, Fatima Cardoso.
J Clin Oncol, 2013 Jul 31; 31(25). PMID: 23897954    Free PMC article.
Highly Cited.
Assignment of tumor subtype by genomic testing and pathologic-based approximations: implications on patient's management and therapy selection.
A Romero, A Prat, +9 authors, M Martín.
Clin Transl Oncol, 2013 Aug 03; 16(4). PMID: 23907291
The management of early-stage and metastatic triple-negative breast cancer: a review.
Carey K Anders, Timothy M Zagar, Lisa A Carey.
Hematol Oncol Clin North Am, 2013 Aug 07; 27(4). PMID: 23915742    Free PMC article.
Review.
Which breast cancer decisions remain non-compliant with guidelines despite the use of computerised decision support?
B Séroussi, C Laouénan, +3 authors, J Bouaud.
Br J Cancer, 2013 Aug 15; 109(5). PMID: 23942076    Free PMC article.
A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions.
Jeff C Liu, Sean E Egan, Eldad Zacksenhaus.
Oncotarget, 2013 Aug 16; 4(8). PMID: 23945331    Free PMC article.
Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine.
Ashley G Rivenbark, Siobhan M O'Connor, William B Coleman.
Am J Pathol, 2013 Sep 03; 183(4). PMID: 23993780    Free PMC article.
Review.
Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice.
Rafat A Siddiqui, Kevin A Harvey, +6 authors, Cary Mariash.
BMC Cancer, 2013 Sep 17; 13. PMID: 24034496    Free PMC article.
Differential activation of Wnt-β-catenin pathway in triple negative breast cancer increases MMP7 in a PTEN dependent manner.
Nandini Dey, Brandon Young, +4 authors, Brian Leyland-Jones.
PLoS One, 2013 Oct 22; 8(10). PMID: 24143235    Free PMC article.
Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index.
Nuria Ribelles, Lidia Perez-Villa, +11 authors, Emilio Alba.
Breast Cancer Res, 2013 Oct 24; 15(5). PMID: 24148581    Free PMC article.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Aleix Prat, Olga Karginova, +8 authors, Charles M Perou.
Breast Cancer Res Treat, 2013 Oct 29; 142(2). PMID: 24162158    Free PMC article.
Highly Cited.
Nuclear expression of snail is an independent negative prognostic factor in human breast cancer.
S Muenst, S Däster, +7 authors, S D Soysal.
Dis Markers, 2013 Nov 06; 35(5). PMID: 24191127    Free PMC article.
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.
Adam D Pfefferle, Jason I Herschkowitz, +9 authors, Charles M Perou.
Genome Biol, 2013 Nov 14; 14(11). PMID: 24220145    Free PMC article.
Highly Cited.
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Tyler J W Robinson, Jeff C Liu, +6 authors, Eldad Zacksenhaus.
PLoS One, 2013 Nov 23; 8(11). PMID: 24265703    Free PMC article.
Tracking progesterone receptor-mediated actions in breast cancer.
Todd P Knutson, Carol A Lange.
Pharmacol Ther, 2013 Dec 03; 142(1). PMID: 24291072    Free PMC article.
Review.
Pituitary tumor-transforming gene 1 is expressed in primary ductal breast carcinoma, lymph node infiltration, and distant metastases.
Fabio Grizzi, Sonia Di Biccari, +2 authors, Piergiuseppe Colombo.
Dis Markers, 2013 Dec 18; 35(4). PMID: 24344401    Free PMC article.
Clinical utility of the combination of lapatinib and letrozole in the management of hormone receptor-positive and HER2-positive advanced breast cancer.
Priscilla Merriam, William M Sikov.
Breast Cancer (Dove Med Press), 2011 Jan 01; 3. PMID: 24367183    Free PMC article.
Review.
A triple negative breast cancer: what it is not!
Suresh B Katakkar.
Breast Cancer (Dove Med Press), 2012 Jan 01; 4. PMID: 24367190    Free PMC article.
Keeping an open mind: highlights and controversies of the breast cancer stem cell theory.
Mansi Shah, Cinzia Allegrucci.
Breast Cancer (Dove Med Press), 2012 Jan 01; 4. PMID: 24367202    Free PMC article.
Review.
Gynecologic biopsy for molecular profiling: a review for the interventional radiologist.
Bradley R Corr, Kian Behbakht, Monique A Spillman.
Semin Intervent Radiol, 2014 Jan 18; 30(4). PMID: 24436571    Free PMC article.
Review.
Epigenetic silencing of ARRDC3 expression in basal-like breast cancer cells.
Young Hwa Soung, Kevin Pruitt, Jun Chung.
Sci Rep, 2014 Jan 25; 4. PMID: 24457910    Free PMC article.
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
Sandro Santagata, Ankita Thakkar, +13 authors, Tan A Ince.
J Clin Invest, 2014 Jan 28; 124(2). PMID: 24463450    Free PMC article.
Highly Cited.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
Hai-Long Piao, Yuan Yuan, +3 authors, Li Ma.
Nat Cell Biol, 2014 Feb 11; 16(3). PMID: 24509793    Free PMC article.
Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics.
Carol Sweeney, Philip S Bernard, +11 authors, Bette J Caan.
Cancer Epidemiol Biomarkers Prev, 2014 Feb 14; 23(5). PMID: 24521995    Free PMC article.
Neoadjuvant endocrine treatment for breast cancer: from bedside to bench and back again?
R R Saleh, N Bouganim, +2 authors, M Clemons.
Curr Oncol, 2014 Feb 14; 21(1). PMID: 24523609    Free PMC article.
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer.
S De Summa, R Pinto, +9 authors, S Tommasi.
Cell Death Dis, 2014 Feb 22; 5. PMID: 24556691    Free PMC article.
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious.
Paola Maycotte, Christy M Gearheart, +8 authors, Andrew Thorburn.
Cancer Res, 2014 Mar 05; 74(9). PMID: 24590058    Free PMC article.
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.
Adam Skibinski, Jerrica L Breindel, +6 authors, Charlotte Kuperwasser.
Cell Rep, 2014 Mar 13; 6(6). PMID: 24613358    Free PMC article.
Highly Cited.
TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families.
Nathalia M Cury, Victor Ef Ferraz, Wilson A Silva.
Hered Cancer Clin Pract, 2014 Mar 15; 12(1). PMID: 24625245    Free PMC article.
Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer.
Xuesong Chen, Lichun Sun, +8 authors, Xiaoqun Dong.
J Exp Clin Cancer Res, 2014 Mar 19; 33. PMID: 24628817    Free PMC article.
microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.
Pierluigi Gasparini, Luciano Cascione, +8 authors, Kay Huebner.
Oncotarget, 2014 Mar 19; 5(5). PMID: 24632568    Free PMC article.
Highly Cited.
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
Mei Hong Zhang, Hong Tao Man, +2 authors, Shi Liang Ma.
Biomed Rep, 2014 Mar 22; 2(1). PMID: 24649067    Free PMC article.
PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells.
Ilaria Plantamura, Patrizia Casalini, +15 authors, Elda Tagliabue.
Mol Oncol, 2014 Apr 22; 8(5). PMID: 24747080    Free PMC article.
Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
Fares Al-Ejeh, Mariska Miranda, +10 authors, Kum Kum Khanna.
Oncotarget, 2014 Apr 26; 5(10). PMID: 24762669    Free PMC article.
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.
Yilin Xu, Xin D Gao, +11 authors, Chonghui Cheng.
Genes Dev, 2014 May 21; 28(11). PMID: 24840202    Free PMC article.
Highly Cited.
Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer.
S Muenst, A R Schaerli, +9 authors, S D Soysal.
Breast Cancer Res Treat, 2014 May 21; 146(1). PMID: 24842267    Free PMC article.
Highly Cited.
Oncogenic roles of EMT-inducing transcription factors.
Alain Puisieux, Thomas Brabletz, Julie Caramel.
Nat Cell Biol, 2014 May 31; 16(6). PMID: 24875735
Highly Cited. Review.
Mammary stem cells and the differentiation hierarchy: current status and perspectives.
Jane E Visvader, John Stingl.
Genes Dev, 2014 Jun 04; 28(11). PMID: 24888586    Free PMC article.
Highly Cited. Review.
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.
J Sternemalm, H G Russnes, +6 authors, S Patzke.
Br J Cancer, 2014 Jun 06; 111(2). PMID: 24901235    Free PMC article.
Fibromatosis-like metaplastic carcinoma of the breast has a claudin-low immunohistochemical phenotype.
Miguel Rito, Fernando Schmitt, António E Pinto, Saudade André.
Virchows Arch, 2014 Jun 07; 465(2). PMID: 24903673
Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer.
Michael D Iglesia, Benjamin G Vincent, +4 authors, Jonathan S Serody.
Clin Cancer Res, 2014 Jun 12; 20(14). PMID: 24916698    Free PMC article.
Highly Cited.
High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation.
Guizhi Dong, Xiaoling Liang, +5 authors, Zhaohui Du.
Med Oncol, 2014 Jun 16; 31(7). PMID: 24930006
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.
Yuhki Yokoyama, Ayaka Matsumoto, +8 authors, Nariaki Matsuura.
Breast Cancer Res, 2014 Jun 24; 16(3). PMID: 24953066    Free PMC article.
Long noncoding RNA profiles identify five distinct molecular subtypes of colorectal cancer with clinical relevance.
Haoyan Chen, Jie Xu, +3 authors, Jing-Yuan Fang.
Mol Oncol, 2014 Jun 24; 8(8). PMID: 24954858    Free PMC article.
Rare breast cancer subtypes: histological, molecular, and clinical peculiarities.
Maria Vittoria Dieci, Enrico Orvieto, +2 authors, Valentina Guarneri.
Oncologist, 2014 Jun 28; 19(8). PMID: 24969162    Free PMC article.
Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone.
Binghe Xu, Zhongzhen Guan, +7 authors, Catherine Ellis.
Breast Cancer Res, 2014 Jul 25; 16(4). PMID: 25056500    Free PMC article.
The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
Michael L Salmans, Zhengquan Yu, +5 authors, Bogi Andersen.
PLoS Genet, 2014 Aug 01; 10(7). PMID: 25079073    Free PMC article.
Molecular homology and difference between spontaneous canine mammary cancer and human breast cancer.
Deli Liu, Huan Xiong, +5 authors, Shaying Zhao.
Cancer Res, 2014 Aug 02; 74(18). PMID: 25082814    Free PMC article.
Predicting response and survival in chemotherapy-treated triple-negative breast cancer.
A Prat, A Lluch, +35 authors, E Alba.
Br J Cancer, 2014 Aug 08; 111(8). PMID: 25101563    Free PMC article.
Targeting autophagy in breast cancer.
Paola Maycotte, Andrew Thorburn.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114840    Free PMC article.
Review.
Biological subtypes of breast cancer: Prognostic and therapeutic implications.
Ozlem Yersal, Sabri Barutca.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114856    Free PMC article.
Highly Cited. Review.
Illuminating breast cancer invasion: diverse roles for cell-cell interactions.
Kevin J Cheung, Andrew J Ewald.
Curr Opin Cell Biol, 2014 Aug 20; 30. PMID: 25137487    Free PMC article.
Review.
Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer.
Aleix Prat, Lisa A Carey, +6 authors, José Baselga.
J Natl Cancer Inst, 2014 Aug 21; 106(8). PMID: 25139534    Free PMC article.
Highly Cited.
Age-specific changes in intrinsic breast cancer subtypes: a focus on older women.
Emily O Jenkins, Allison M Deal, +4 authors, Hyman B Muss.
Oncologist, 2014 Aug 22; 19(10). PMID: 25142841    Free PMC article.
MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1.
Sriganesh B Sharma, Chen-Chung Lin, +5 authors, J Michael Ruppert.
Mol Cell Biol, 2014 Sep 10; 34(22). PMID: 25202123    Free PMC article.
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.
Matthew D Burstein, Anna Tsimelzon, +10 authors, Powel H Brown.
Clin Cancer Res, 2014 Sep 12; 21(7). PMID: 25208879    Free PMC article.
Highly Cited.
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.
Tuan Zea Tan, Qing Hao Miow, +4 authors, Jean Paul Thiery.
EMBO Mol Med, 2014 Sep 13; 6(10). PMID: 25214461    Free PMC article.
Highly Cited.
Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.
Kaihua Zhang, Lamont Jones, +10 authors, Loren S Michel.
Oncotarget, 2014 Sep 23; 5(19). PMID: 25238142    Free PMC article.
Triple-negative vimentin-positive heterogeneous feline mammary carcinomas as a potential comparative model for breast cancer.
Diego Caliari, Valentina Zappulli, +4 authors, Massimo Castagnaro.
BMC Vet Res, 2014 Sep 25; 10. PMID: 25249140    Free PMC article.
Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy.
Sandro Santagata, Tan A Ince.
Expert Rev Anticancer Ther, 2014 Sep 30; 14(12). PMID: 25263303    Free PMC article.
EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer.
Maria J Serrano, Francisco G Ortega, +12 authors, Jose A Lorente.
Oncotarget, 2014 Oct 04; 5(17). PMID: 25277187    Free PMC article.
DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.
Kathleen Conway, Sharon N Edmiston, +8 authors, Robert C Millikan.
Breast Cancer Res, 2014 Oct 08; 16(5). PMID: 25287138    Free PMC article.
The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.
Sercan Ergün, Mustafa Ulasli, +9 authors, Serdar Oztuzcu.
Mol Biol Rep, 2014 Oct 17; 42(2). PMID: 25318895
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
Jeff C Liu, Veronique Voisin, +10 authors, Eldad Zacksenhaus.
EMBO Mol Med, 2014 Oct 22; 6(12). PMID: 25330770    Free PMC article.
Update on adjuvant chemotherapy for early breast cancer.
Murtuza M Rampurwala, Gabrielle B Rocque, Mark E Burkard.
Breast Cancer (Auckl), 2014 Oct 23; 8. PMID: 25336961    Free PMC article.
Review.
Differentiation and loss of malignant character of spontaneous pulmonary metastases in patient-derived breast cancer models.
Jessica Bockhorn, Aleix Prat, +9 authors, Huiping Liu.
Cancer Res, 2014 Oct 24; 74(24). PMID: 25339353    Free PMC article.
Neoadjuvant therapy of early stage human epidermal growth factor receptor 2 positive breast cancer: latest evidence and clinical implications.
Sonia Pernas Simon.
Ther Adv Med Oncol, 2014 Oct 25; 6(5). PMID: 25342988    Free PMC article.
Review.
Standard of care and promising new agents for triple negative metastatic breast cancer.
Patrizia Mancini, Antonio Angeloni, +2 authors, Silvia Mezi.
Cancers (Basel), 2014 Oct 28; 6(4). PMID: 25347122    Free PMC article.
Review.
Differential β₂-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines.
Lucía Gargiulo, Sabrina Copsel, +5 authors, Ariana Bruzzone.
Oncotarget, 2014 Nov 07; 5(20). PMID: 25375203    Free PMC article.
The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.
Kristen L Karlin, Gourish Mondal, +22 authors, Thomas F Westbrook.
Cell Rep, 2014 Dec 03; 9(4). PMID: 25453754    Free PMC article.
Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer.
Christiana S Kappler, Stephen T Guest, +4 authors, Stephen P Ethier.
Mol Oncol, 2014 Dec 03; 9(2). PMID: 25454348    Free PMC article.
Metabolic characterization of triple negative breast cancer.
Maria D Cao, Santosh Lamichhane, +4 authors, Tone F Bathen.
BMC Cancer, 2014 Dec 17; 14. PMID: 25495193    Free PMC article.
Targeting SH2 domains in breast cancer.
Pietro Morlacchi, Fredika M Robertson, Jim Klostergaard, John S McMurray.
Future Med Chem, 2014 Dec 17; 6(17). PMID: 25495984    Free PMC article.
Review.
Twist-BRD4 complex: potential drug target for basal-like breast cancer.
Jian Shi, Jingying Cao, Binhua P Zhou.
Curr Pharm Des, 2014 Dec 17; 21(10). PMID: 25506891    Free PMC article.
Review.
Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival.
Gary Tozbikian, Edi Brogi, +9 authors, Hannah Yong Wen.
PLoS One, 2014 Dec 17; 9(12). PMID: 25506917    Free PMC article.
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.
Mohammad Fallahi, Antonio L Amelio, John L Cleveland, Robert J Rounbehler.
PLoS One, 2014 Dec 30; 9(12). PMID: 25541715    Free PMC article.
EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?
Stéphane Ansieau, Guillaume Collin, Louise Hill.
Front Oncol, 2015 Jan 08; 4. PMID: 25566496    Free PMC article.
Review.
Normal cell-type epigenetics and breast cancer classification: a case study of cell mixture-adjusted analysis of DNA methylation data from tumors.
Eugene Andrés Houseman, Tan A Ince.
Cancer Inform, 2015 Jan 13; 13(Suppl 4). PMID: 25574126    Free PMC article.
Intrinsic cancer subtypes--next steps into personalized medicine.
Cristina Santos, Rebeca Sanz-Pamplona, +6 authors, Ramon Salazar.
Cell Oncol (Dordr), 2015 Jan 15; 38(1). PMID: 25586691
Review.
Resistance to HER2-targeted therapies: a potential role for FOXM1.
Bridgette F Peake, Rita Nahta.
Breast Cancer Manag, 2015 Jan 20; 3(5). PMID: 25598845    Free PMC article.
Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery.
François Planeix, Mohammad-Ahsan Siraj, +5 authors, Nicolae Ghinea.
J Exp Clin Cancer Res, 2015 Feb 06; 34. PMID: 25652007    Free PMC article.
Triple-negative breast cancer: new perspectives for targeted therapies.
Federica Tomao, Anselmo Papa, +6 authors, Silverio Tomao.
Onco Targets Ther, 2015 Feb 06; 8. PMID: 25653541    Free PMC article.
Highly Cited. Review.
Gene expression-based classifications of fibroadenomas and phyllodes tumours of the breast.
Maria Vidal, Vicente Peg, +5 authors, Aleix Prat.
Mol Oncol, 2015 Feb 18; 9(6). PMID: 25687451    Free PMC article.
The origin of breast tumor heterogeneity.
A Skibinski, C Kuperwasser.
Oncogene, 2015 Feb 24; 34(42). PMID: 25703331    Free PMC article.
Highly Cited. Review.
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors.
Yihsuan S Tsai, Daniel Dominguez, Shawn M Gomez, Zefeng Wang.
Oncotarget, 2015 Mar 10; 6(9). PMID: 25749525    Free PMC article.
Critical analysis of the potential for microRNA biomarkers in breast cancer management.
Carrie R Graveel, Heather M Calderone, +2 authors, Lorenzo F Sempere.
Breast Cancer (Dove Med Press), 2015 Mar 12; 7. PMID: 25759599    Free PMC article.
Review.
Can molecular subtyping replace axillary nodal status as prognostic marker in breast cancer?
Debarshi Jana, Diptendra Kumar Sarkar, +3 authors, Syamsundar Mandal.
Indian J Surg Oncol, 2015 Mar 15; 5(4). PMID: 25767340    Free PMC article.
The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors.
Chiara Tordonato, Pier Paolo Di Fiore, Francesco Nicassio.
Front Genet, 2015 Mar 17; 6. PMID: 25774169    Free PMC article.
Review.
Significance of Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer Patients within a Randomized, Phase II Trial: TBCRC 019.
Costanza Paoletti, Yufeng Li, +18 authors, Translational Breast Cancer Research Consortium (TBCRC).
Clin Cancer Res, 2015 Mar 18; 21(12). PMID: 25779948    Free PMC article.
Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells.
Jonathan K Lee, James C Garbe, +4 authors, Mark A LaBarge.
Front Cell Dev Biol, 2015 Mar 31; 3. PMID: 25815289    Free PMC article.
Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.
Olga Karginova, Marni B Siegel, +15 authors, Carey K Anders.
Mol Cancer Ther, 2015 Apr 01; 14(4). PMID: 25824335    Free PMC article.
Molecular subtyping for clinically defined breast cancer subgroups.
Xi Zhao, Einar Andreas Rødland, Robert Tibshirani, Sylvia Plevritis.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849221    Free PMC article.
Patient-derived xenograft models of breast cancer and their predictive power.
James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849559    Free PMC article.
Highly Cited. Review.
Identifying and targeting tumor-initiating cells in the treatment of breast cancer.
Wei Wei, Michael T Lewis.
Endocr Relat Cancer, 2015 Apr 17; 22(3). PMID: 25876646    Free PMC article.
Review.
Therapies for triple negative breast cancer.
Eleni Andreopoulou, Sarah J Schweber, Joseph A Sparano, Hayley M McDaid.
Expert Opin Pharmacother, 2015 Apr 18; 16(7). PMID: 25881743    Free PMC article.
Review.
Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response.
Pascal Jézéquel, Delphine Loussouarn, +8 authors, Mario Campone.
Breast Cancer Res, 2015 Apr 19; 17. PMID: 25887482    Free PMC article.
Highly Cited.
The proteomic landscape of triple-negative breast cancer.
Robert T Lawrence, Elizabeth M Perez, +6 authors, Judit Villén.
Cell Rep, 2015 Apr 22; 11(4). PMID: 25892236    Free PMC article.
Highly Cited.
Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.
Kwang-Youn Kim, Sang-Hun Kim, +6 authors, Soon-Cheol Ahn.
Mol Med Rep, 2015 Apr 22; 12(2). PMID: 25892525    Free PMC article.
HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer.
Vineesh Indira Chandran, Serenella Eppenberger-Castori, +2 authors, Marie Ranson.
Oncoscience, 2015 Apr 22; 2(3). PMID: 25897424    Free PMC article.
Review.
Targeted nanoparticles for image-guided treatment of triple-negative breast cancer: clinical significance and technological advances.
Jasmine M Miller-Kleinhenz, Erica N Bozeman, Lily Yang.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2015 May 15; 7(6). PMID: 25966677    Free PMC article.
Review.
Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties.
Elisabet Cuyàs, Begoña Martin-Castillo, +3 authors, Javier A Menendez.
Cell Cycle, 2015 May 15; 14(22). PMID: 25970790    Free PMC article.
Androgen Receptor (AR), E-Cadherin, and Ki-67 as Emerging Targets and Novel Prognostic Markers in Triple-Negative Breast Cancer (TNBC) Patients.
Giuseppina Rosaria Rita Ricciardi, Barbara Adamo, +6 authors, Vincenzo Adamo.
PLoS One, 2015 Jun 04; 10(6). PMID: 26039245    Free PMC article.
Characterization of the Tyrosine Kinase-Regulated Proteome in Breast Cancer by Combined use of RNA interference (RNAi) and Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) Quantitative Proteomics.
Justin Stebbing, Hua Zhang, +4 authors, Georgios Giamas.
Mol Cell Proteomics, 2015 Jun 20; 14(9). PMID: 26089344    Free PMC article.
Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer.
Grace O Silva, Xiaping He, +8 authors, Charles M Perou.
Breast Cancer Res Treat, 2015 Jun 26; 152(2). PMID: 26109346    Free PMC article.
A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome.
Rama Soundararajan, Anurag N Paranjape, +2 authors, Sendurai A Mani.
Sci Rep, 2015 Jul 01; 5. PMID: 26123483    Free PMC article.
Enhanced NK cell adoptive antitumor effects against breast cancer in vitro via blockade of the transforming growth factor-β signaling pathway.
Yue Zhao, Jinyue Hu, +4 authors, Dongwei Zhang.
Onco Targets Ther, 2015 Jul 01; 8. PMID: 26124672    Free PMC article.
Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival.
Subhasis Das, Gautam Sondarva, +5 authors, Ajay Rana.
J Biol Chem, 2015 Jul 15; 290(35). PMID: 26152725    Free PMC article.
Navigating the Challenges of Endocrine Treatments in Premenopausal Women with ER-Positive Early Breast Cancer.
Marco Colleoni, Elisabetta Munzone.
Drugs, 2015 Jul 17; 75(12). PMID: 26177891
Review.
Monitoring therapeutic efficacy of sunitinib using [(18)F]FDG and [(18)F]FMISO PET in an immunocompetent model of luminal B (HER2-positive)-type mammary carcinoma.
Benoît Thézé, Nicholas Bernards, +5 authors, Raphaël Boisgard.
BMC Cancer, 2015 Jul 23; 15. PMID: 26198000    Free PMC article.
The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes.
Amulya Sreekumar, Kevin Roarty, Jeffrey M Rosen.
Endocr Relat Cancer, 2015 Jul 25; 22(6). PMID: 26206777    Free PMC article.
Review.
Decoding breast cancer tissue-stroma interactions using species-specific sequencing.
Indira V Chivukula, Daniel Ramsköld, +7 authors, Urban Lendahl.
Breast Cancer Res, 2015 Aug 13; 17. PMID: 26265142    Free PMC article.
Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.
Gabriela Dontu, Tan A Ince.
J Mammary Gland Biol Neoplasia, 2015 Aug 20; 20(1-2). PMID: 26286174    Free PMC article.
Review.
ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program.
Tuyen T Dang, Matthew A Esparza, +2 authors, Gray W Pearson.
Cancer Res, 2015 Aug 21; 75(18). PMID: 26292362    Free PMC article.
Exometabolom analysis of breast cancer cell lines: Metabolic signature.
Lucas Willmann, Thalia Erbes, +7 authors, Bernd Kammerer.
Sci Rep, 2015 Aug 22; 5. PMID: 26293811    Free PMC article.
Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.
Siker Kimbung, Anikó Kovács, +10 authors, Ingrid Hedenfalk.
Oncotarget, 2015 Sep 17; 6(32). PMID: 26375671    Free PMC article.
N0436 (Alliance): A Phase II Trial of Irinotecan With Cetuximab in Patients With Metastatic Breast Cancer Previously Exposed to Anthracycline and/or Taxane-Containing Therapy.
Jennifer A Crozier, Pooja P Advani, +4 authors, Edith A Perez.
Clin Breast Cancer, 2015 Sep 19; 16(1). PMID: 26381420    Free PMC article.
Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity.
Aristeidis G Telonis, Phillipe Loher, +2 authors, Isidore Rigoutsos.
Nucleic Acids Res, 2015 Sep 25; 43(19). PMID: 26400174    Free PMC article.
Highly Cited.
Targeting HER2 Positive Breast Cancer with Chemopreventive Agents.
Joseph Wahler, Nanjoo Suh.
Curr Pharmacol Rep, 2015 Oct 07; 1(5). PMID: 26442201    Free PMC article.
Comprehensive profiling of biological processes reveals two major prognostic subtypes in breast cancer.
Fei Chen, Sheng Gao, +7 authors, Hong Yin.
Tumour Biol, 2015 Oct 09; 37(3). PMID: 26446459
Chemotherapy of metastatic triple negative breast cancer: Experience of using platinum-based chemotherapy.
Jian Zhang, Minhao Fan, +8 authors, Xichun Hu.
Oncotarget, 2015 Oct 09; 6(40). PMID: 26447756    Free PMC article.
Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas.
Begoña Martin-Castillo, Eugeni Lopez-Bonet, +4 authors, Javier A Menendez.
Oncotarget, 2015 Oct 17; 6(32). PMID: 26474458    Free PMC article.
Cancer classification in the genomic era: five contemporary problems.
Qingxuan Song, Sofia D Merajver, Jun Z Li.
Hum Genomics, 2015 Oct 21; 9. PMID: 26481255    Free PMC article.
Review.
Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis.
Benjamin Leyh, Angela Dittmer, +2 authors, Jürgen Dittmer.
Oncotarget, 2015 Oct 31; 6(36). PMID: 26515727    Free PMC article.
Gene-expression signature functional annotation of breast cancer tumours in function of age.
Pascal Jézéquel, Zein Sharif, +5 authors, Mario Campone.
BMC Med Genomics, 2015 Nov 26; 8. PMID: 26597277    Free PMC article.
Evaluation of breast cancer using intravoxel incoherent motion (IVIM) histogram analysis: comparison with malignant status, histological subtype, and molecular prognostic factors.
Gene Young Cho, Linda Moy, +5 authors, Eric E Sigmund.
Eur Radiol, 2015 Nov 30; 26(8). PMID: 26615557    Free PMC article.
MiRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer.
Andrea Mathe, Rodney J Scott, Kelly A Avery-Kiejda.
Int J Mol Sci, 2015 Dec 04; 16(12). PMID: 26633365    Free PMC article.
Review.
Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse.
Claudette Falato, Nicholas P Tobin, +3 authors, Theodoros Foukakis.
Mol Oncol, 2015 Dec 15; 10(4). PMID: 26651914    Free PMC article.
Response and survival of breast cancer intrinsic subtypes following multi-agent neoadjuvant chemotherapy.
Aleix Prat, Cheng Fan, +11 authors, Charles M Perou.
BMC Med, 2015 Dec 20; 13. PMID: 26684470    Free PMC article.
An update in breast cancer screening and management.
Sanjay Warrier, Grace Tapia, David Goltsman, Jane Beith.
Womens Health (Lond), 2015 Dec 23; 12(2). PMID: 26689336    Free PMC article.
Review.
Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.
Karin Zins, Barbara Frech, +3 authors, Martin Schreiber.
Int J Mol Sci, 2015 Dec 23; 16(12). PMID: 26690424    Free PMC article.
Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.
Paige Chandler, Bose S Kochupurakkal, +3 authors, Shannon L Kelleher.
Mol Cancer, 2016 Jan 06; 15. PMID: 26728511    Free PMC article.
Breast cancer subtypes: morphologic and biologic characterization.
Shahla Masood.
Womens Health (Lond), 2016 Jan 13; 12(1). PMID: 26756229    Free PMC article.
Clinical verification of sensitivity to preoperative chemotherapy in cases of androgen receptor-expressing positive breast cancer.
Yuka Asano, Shinichiro Kashiwagi, +7 authors, Kosei Hirakawa.
Br J Cancer, 2016 Jan 13; 114(1). PMID: 26757422    Free PMC article.
The TRAIL receptor agonist drozitumab targets basal B triple-negative breast cancer cells that express vimentin and Axl.
Jennifer L Dine, Ciara C O'Sullivan, +11 authors, Stanley Lipkowitz.
Breast Cancer Res Treat, 2016 Jan 14; 155(2). PMID: 26759246    Free PMC article.
Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma.
Hyosun Kim, Jihyoung Cho, Sun Young Kwon, Sun Hee Kang.
Ann Surg Treat Res, 2016 Jan 23; 90(1). PMID: 26793686    Free PMC article.
Impact of Breast Cancer Subtype Defined by Immunohistochemistry Hormone Receptor and HER2 Status on the Incidence of Immediate Postmastectomy Reconstruction.
Wei Wu, Shi Cheng, +3 authors, Minghui Cao.
Medicine (Baltimore), 2016 Jan 29; 95(3). PMID: 26817902    Free PMC article.
BEYOND TEXT: USING ARRAYS TO REPRESENT AND ANALYZE ETHNOGRAPHIC DATA.
Corey M Abramson, Daniel Dohan.
Sociol Methodol, 2016 Feb 03; 45(1). PMID: 26834296    Free PMC article.
Brain metastasis in breast cancer: a comprehensive literature review.
Rezvan Rostami, Shivam Mittal, +2 authors, Bahman Jabbari.
J Neurooncol, 2016 Feb 26; 127(3). PMID: 26909695
Highly Cited. Review.
MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer.
Lei Huo, Yan Wang, +19 authors, Zhuang Zuo.
Mod Pathol, 2016 Feb 27; 29(4). PMID: 26916073
Targeting the RB-E2F pathway in breast cancer.
J Johnson, B Thijssen, +3 authors, R Bernards.
Oncogene, 2016 Mar 01; 35(37). PMID: 26923330    Free PMC article.
Highly Cited. Review.
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
Maria Cristina Rangel, Daniel Bertolette, +3 authors, David S Salomon.
Breast Cancer Res Treat, 2016 Mar 13; 156(2). PMID: 26968398    Free PMC article.
Review.
Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.
Chanèle Cyr-Depauw, Jason J Northey, +7 authors, Peter M Siegel.
Mol Cell Biol, 2016 Mar 16; 36(10). PMID: 26976638    Free PMC article.
Prognostic analysis of triple-negative breast cancer patients treated with adjuvant chemotherapy of fluorouracil, epirubicin and cyclophosphamide.
Weiling Sun, Chunhong Li, +3 authors, L I Cai.
Oncol Lett, 2016 Mar 22; 11(3). PMID: 26998170    Free PMC article.
Estrogen Receptor Expression Is Associated with DNA Repair Capacity in Breast Cancer.
Jaime Matta, Luisa Morales, +6 authors, Erick Suárez.
PLoS One, 2016 Apr 01; 11(3). PMID: 27032101    Free PMC article.
Tumor-Infiltrating Lymphocytes in Triple Negative Breast Cancer: The Future of Immune Targeting.
Paula García-Teijido, María Luque Cabal, Ignacio Peláez Fernández, Yolanda Fernández Pérez.
Clin Med Insights Oncol, 2016 Apr 16; 10(Suppl 1). PMID: 27081325    Free PMC article.
Highly Cited. Review.
Cell Fate Decisions During Breast Cancer Development.
Kayla Gross, Ania Wronski, +2 authors, Charlotte Kuperwasser.
J Dev Biol, 2016 Apr 26; 4(1). PMID: 27110512    Free PMC article.
Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.
Adam D Pfefferle, Yash N Agrawal, +5 authors, Charles M Perou.
Dis Model Mech, 2016 May 07; 9(7). PMID: 27149990    Free PMC article.
MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer.
Magdalena A Cichon, Megan E Moruzzi, +6 authors, Derek C Radisky.
Cancer Res, 2016 May 20; 76(12). PMID: 27197167    Free PMC article.
Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.
Campbell D Lawson, Cheng Fan, +7 authors, Kent L Rossman.
Cancer Res, 2016 May 25; 76(13). PMID: 27216196    Free PMC article.
Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response.
Norbert Nass, Angela Dittmer, +9 authors, Jürgen Dittmer.
Oncotarget, 2016 Oct 23; 7(25). PMID: 27224909    Free PMC article.
Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer.
Mahdieh Jadaliha, Xinying Zong, +8 authors, Kannanganattu V Prasanth.
Oncotarget, 2016 Oct 27; 7(26). PMID: 27250026    Free PMC article.
Highly Cited.
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.
Nicole S Spoelstra, Diana M Cittelly, +4 authors, Jennifer K Richer.
Hum Pathol, 2016 Jun 05; 56. PMID: 27260947    Free PMC article.
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1.
Krysta M Coyle, J Patrick Murphy, +13 authors, Paola Marcato.
Oncotarget, 2016 Jun 11; 7(28). PMID: 27286452    Free PMC article.
Treatment and survival patterns of Chinese patients diagnosed with breast cancer between 2005 and 2009 in Southwest China: An observational, population-based cohort study.
Zuxiang Peng, Jia Wei, +5 authors, Jing Jing.
Medicine (Baltimore), 2016 Jun 24; 95(25). PMID: 27336872    Free PMC article.
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
Xiaofeng Dai, Liangjian Xiang, Ting Li, Zhonghu Bai.
J Cancer, 2016 Jul 09; 7(10). PMID: 27390604    Free PMC article.
Highly Cited. Review.
Biology and Management of Patients With Triple-Negative Breast Cancer.
Priyanka Sharma.
Oncologist, 2016 Jul 13; 21(9). PMID: 27401886    Free PMC article.
Review.
Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.
Maria Theresa E Montales, Stepan B Melnyk, +3 authors, Rosalia C M Simmen.
Endocr Relat Cancer, 2016 Jul 13; 23(9). PMID: 27402613    Free PMC article.
Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cells.
Miao Li, Xi Li, +6 authors, Bin Shan.
Oncotarget, 2016 Jul 14; 7(32). PMID: 27409175    Free PMC article.
EMT in Breast Carcinoma-A Review.
Joema Felipe Lima, Sharon Nofech-Mozes, Jane Bayani, John M S Bartlett.
J Clin Med, 2016 Jul 20; 5(7). PMID: 27429011    Free PMC article.
Review.
MiRNAs-mediated cisplatin resistance in breast cancer.
Xiu Chen, Peng Lu, +7 authors, Jin-Hai Tang.
Tumour Biol, 2016 Jul 23; 37(10). PMID: 27448297
Review.
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.
Robert A Jones, Tyler J Robinson, +15 authors, Eldad Zacksenhaus.
J Clin Invest, 2016 Aug 30; 126(10). PMID: 27571409    Free PMC article.
Current Status of Long Non-Coding RNAs in Human Breast Cancer.
Stefanie Cerk, Daniela Schwarzenbacher, +6 authors, Martin Pichler.
Int J Mol Sci, 2016 Sep 09; 17(9). PMID: 27608009    Free PMC article.
Review.
Prognosis of breast cancer molecular subtypes in routine clinical care: A large prospective cohort study.
André Hennigs, Fabian Riedel, +13 authors, Andreas Schneeweiss.
BMC Cancer, 2016 Sep 17; 16(1). PMID: 27634735    Free PMC article.
Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases.
José Esparza-López, Pier A Ramos-Elías, +6 authors, María de Jesus Ibarra-Sánchez.
BMC Cancer, 2016 Sep 21; 16(1). PMID: 27645148    Free PMC article.
Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.
Campbell D Lawson, Channing J Der.
Small GTPases, 2016 Sep 23; 9(4). PMID: 27657701    Free PMC article.
Review.
The expressions of NEDD9 and E-cadherin correlate with metastasis and poor prognosis in triple-negative breast cancer patients.
Peng Li, Tingting Sun, +3 authors, Diwen Sun.
Onco Targets Ther, 2016 Oct 06; 9. PMID: 27703373    Free PMC article.
Chemotherapy response and survival of inflammatory breast cancer by hormone receptor- and HER2-defined molecular subtypes approximation: an analysis from the National Cancer Database.
Jieqiong Liu, Kai Chen, +5 authors, Lisa K Jacobs.
J Cancer Res Clin Oncol, 2016 Oct 06; 143(1). PMID: 27704268
Triple-negative breast cancer: is there a treatment on the horizon?
Hui Yao, Guangchun He, +4 authors, Xiyun Deng.
Oncotarget, 2016 Oct 22; 8(1). PMID: 27765921    Free PMC article.
Highly Cited. Review.
Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts.
Shawna B Matthews, Carol A Sartorius.
Horm Cancer, 2016 Nov 01; 8(1). PMID: 27796944    Free PMC article.
Review.
Association of PTP1B with Outcomes of Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy.
Monica M Rivera Franco, Eucario Leon Rodriguez, +3 authors, Alejandra Armengol Alonso.
Breast Cancer (Auckl), 2016 Nov 15; 10. PMID: 27840578    Free PMC article.
TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.
X Su, M Napoli, +10 authors, E R Flores.
Oncogene, 2016 Nov 22; 36(17). PMID: 27869165    Free PMC article.
An emerging role for IQGAP1 in tight junction control.
Barbara E Tanos, Charles Yeaman, Enrique Rodriguez-Boulan.
Small GTPases, 2016 Nov 24; 9(5). PMID: 27880081    Free PMC article.
Review.
Oestrogen receptor negativity in breast cancer: a cause or consequence?
Vijaya Narasihma Reddy Gajulapalli, Vijaya Lakshmi Malisetty, Suresh Kumar Chitta, Bramanandam Manavathi.
Biosci Rep, 2016 Nov 26; 36(6). PMID: 27884978    Free PMC article.
Review.
Recent perspectives of breast cancer prognosis and predictive factors.
Su-Sheng Cao, Cun-Tao Lu.
Oncol Lett, 2016 Dec 03; 12(5). PMID: 27900052    Free PMC article.
A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse.
Aleix Prat, Ana Lluch, +22 authors, Emilio Alba.
Clin Cancer Res, 2016 Dec 03; 23(12). PMID: 27903675    Free PMC article.
Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Lacey E Dobrolecki, Susie D Airhart, +29 authors, Michael T Lewis.
Cancer Metastasis Rev, 2016 Dec 28; 35(4). PMID: 28025748    Free PMC article.
Highly Cited. Review.
Claudin-Low Breast Cancer; Clinical & Pathological Characteristics.
Kay Dias, Anna Dvorkin-Gheva, +6 authors, Anita L Bane.
PLoS One, 2017 Jan 04; 12(1). PMID: 28045912    Free PMC article.
A Novel Effect of β-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer.
Lucía Gargiulo, María May, +7 authors, Ariana Bruzzone.
J Mammary Gland Biol Neoplasia, 2017 Jan 12; 22(1). PMID: 28074314
A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes.
Eric A Ariazi, John C Taylor, +4 authors, Jeff Boyd.
Mol Cancer Res, 2017 Jan 22; 15(2). PMID: 28108626    Free PMC article.
Clinical applications of mouse models for breast cancer engaging HER2/neu.
Elizabeth A Fry, Pankaj Taneja, Kazushi Inoue.
Integr Cancer Sci Ther, 2017 Jan 31; 3(5). PMID: 28133539    Free PMC article.
Low utility of Oncotype DX® in the clinic.
Luisel J Ricks-Santi, John Tyson McDonald.
Cancer Med, 2017 Feb 02; 6(3). PMID: 28145091    Free PMC article.
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer.
Ann Rita Halvorsen, Åslaug Helland, +7 authors, Vilde D Haakensen.
Mol Oncol, 2017 Feb 02; 11(2). PMID: 28145100    Free PMC article.
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.
Ohad Tarcic, Roy Z Granit, +8 authors, Moshe Oren.
Cell Death Differ, 2017 Feb 06; 24(4). PMID: 28157208    Free PMC article.
Understanding breast cancer - The long and winding road.
Kiven Erique Lukong.
BBA Clin, 2017 Feb 15; 7. PMID: 28194329    Free PMC article.
Review.
Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.
Juan M Cejalvo, Eduardo Martínez de Dueñas, +24 authors, Aleix Prat.
Cancer Res, 2017 Mar 03; 77(9). PMID: 28249905    Free PMC article.
Highly Cited.
MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
Robert J Mobley, Deepthi Raghu, +8 authors, Amy N Abell.
Cell Rep, 2017 Mar 09; 18(10). PMID: 28273454    Free PMC article.
Phase Ib dose-finding trial of lapatinib plus pegylated liposomal doxorubicin in advanced HER2-positive breast cancer.
Andrea Rocca, Lorenzo Cecconetto, +13 authors, Dino Amadori.
Cancer Chemother Pharmacol, 2017 Mar 28; 79(5). PMID: 28341957    Free PMC article.
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.
Kuan-Lin Huang, Shunqiang Li, +42 authors, Li Ding.
Nat Commun, 2017 Mar 30; 8. PMID: 28348404    Free PMC article.
Highly Cited.
In vivo models in breast cancer research: progress, challenges and future directions.
Ingunn Holen, Valerie Speirs, Bethny Morrissey, Karen Blyth.
Dis Model Mech, 2017 Apr 07; 10(4). PMID: 28381598    Free PMC article.
Review.
Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer.
Chuanwei Yang, Xuemei Zhao, Naipeng Cui, Yulong Liang.
Stem Cells Int, 2017 Apr 11; 2017. PMID: 28392805    Free PMC article.
Fatty acid metabolism in breast cancer subtypes.
Marie E Monaco.
Oncotarget, 2017 Apr 17; 8(17). PMID: 28412757    Free PMC article.
Review.
GD2 expression in breast cancer.
Giulia Orsi, Monica Barbolini, +15 authors, Massimo Dominici.
Oncotarget, 2017 Apr 19; 8(19). PMID: 28415563    Free PMC article.
Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.
Yuan Yang, Howard H Yang, +10 authors, Lalage M Wakefield.
Oncotarget, 2017 Apr 22; 8(19). PMID: 28430642    Free PMC article.
A murine preclinical syngeneic transplantation model for breast cancer precision medicine.
Lorenzo Federico, Zechen Chong, +18 authors, Gordon B Mills.
Sci Adv, 2017 Apr 26; 3(4). PMID: 28439535    Free PMC article.
Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.
Yuh-Jin Liang, Chen-Yu Wang, +9 authors, John Yu.
Oncotarget, 2017 May 26; 8(29). PMID: 28537895    Free PMC article.
Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field.
Clinton Yam, Sendurai A Mani, Stacy L Moulder.
Oncologist, 2017 Jun 01; 22(9). PMID: 28559413    Free PMC article.
Review.
CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.
Eric Raspé, Katia Coulonval, +14 authors, Pierre P Roger.
EMBO Mol Med, 2017 Jun 02; 9(8). PMID: 28566333    Free PMC article.
Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells.
Joshua M Jackson, Małgorzata A Witek, Joyce W Kamande, Steven A Soper.
Chem Soc Rev, 2017 Jun 21; 46(14). PMID: 28632258    Free PMC article.
Review.
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.
Geoffrey M Wahl, Benjamin T Spike.
NPJ Breast Cancer, 2017 Jun 27; 3. PMID: 28649654    Free PMC article.
Highly Cited.
Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression.
K Roarty, A D Pfefferle, +2 authors, J M Rosen.
Oncogene, 2017 Jun 27; 36(43). PMID: 28650466    Free PMC article.
CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.
Najat Binothman, Ibrahim Y Hachim, Jean-Jacques Lebrun, Suhad Ali.
EBioMedicine, 2017 Jul 05; 21. PMID: 28673861    Free PMC article.
Epithelial-to-Pericyte Transition in Cancer.
Jianrong Lu, Anitha K Shenoy.
Cancers (Basel), 2017 Jul 06; 9(7). PMID: 28677655    Free PMC article.
Review.
PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance).
Minetta C Liu, Brandelyn N Pitcher, +20 authors, William T Barry.
NPJ Breast Cancer, 2016 Jan 01; 2. PMID: 28691057    Free PMC article.
Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair.
Jaime Matta, Carmen Ortiz, +2 authors, Erick Suárez.
Int J Mol Sci, 2017 Jul 15; 18(7). PMID: 28704967    Free PMC article.
Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants.
Fresia Pareja, Felipe C Geyer, +3 authors, Jorge S Reis-Filho.
NPJ Breast Cancer, 2017 Jul 20; 2. PMID: 28721389    Free PMC article.
Highly Cited. Review.
The Epigenetic Landscape of Promoter Genome-wide Analysis in Breast Cancer.
Seher Karsli-Ceppioglu, Aslihan Dagdemir, +4 authors, Dominique Bernard-Gallon.
Sci Rep, 2017 Jul 28; 7(1). PMID: 28747748    Free PMC article.
HER2-positive breast cancer is lost in translation: time for patient-centered research.
Isabelle Gingras, Géraldine Gebhart, Evandro de Azambuja, Martine Piccart-Gebhart.
Nat Rev Clin Oncol, 2017 Aug 02; 14(11). PMID: 28762384
Review.
ErbB2 signaling epigenetically suppresses microRNA-205 transcription via Ras/Raf/MEK/ERK pathway in breast cancer.
Takuya Hasegawa, Ryohei Adachi, +3 authors, Toshiyuki Sakamaki.
FEBS Open Bio, 2017 Aug 07; 7(8). PMID: 28781955    Free PMC article.
Induction of a novel isoform of the lncRNA HOTAIR in Claudin-low breast cancer cells attached to extracellular matrix.
Miao Li, Xi Li, +3 authors, Bin Shan.
Mol Oncol, 2017 Aug 29; 11(12). PMID: 28846832    Free PMC article.
The cell-of-origin dictates the genomic landscape of breast cancers.
Alain Puisieux, Roxane M Pommier, Agnès Tissier, Anne-Pierre Morel.
Mol Cell Oncol, 2017 Sep 05; 4(4). PMID: 28868351    Free PMC article.
Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model.
Altug Ozcelikkale, Kyeonggon Shin, +7 authors, Bumsoo Han.
J Control Release, 2017 Sep 25; 266. PMID: 28939108    Free PMC article.
Wound fluids affect miR-21, miR-155 and miR-221 expression in breast cancer cell lines, and this effect is partially abrogated by intraoperative radiation therapy treatment.
Karolina Zaleska, Anna Przybyła, +4 authors, Dawid Murawa.
Oncol Lett, 2017 Sep 26; 14(4). PMID: 28943910    Free PMC article.
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients.
Nicholas P Tobin, Arian Lundberg, +13 authors, TEX Trialists Group.
Clin Cancer Res, 2017 Oct 04; 23(23). PMID: 28972041    Free PMC article.
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.
Arian Lundberg, Linda S Lindström, +8 authors, Nicholas P Tobin.
Clin Cancer Res, 2017 Oct 04; 23(24). PMID: 28972043    Free PMC article.
Revisiting the impact of age and molecular subtype on overall survival after radiotherapy in breast cancer patients.
Jian-Hua Mao, Paul J van Diest, Jesus Perez-Losada, Antoine M Snijders.
Sci Rep, 2017 Oct 05; 7(1). PMID: 28974723    Free PMC article.
The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition.
Joseph H Taube, Nathalie Sphyris, +11 authors, Sendurai A Mani.
Oncotarget, 2017 Oct 17; 8(39). PMID: 29029452    Free PMC article.
Targeting the androgen receptor in triple-negative breast cancer: current perspectives.
Alain Mina, Rachel Yoder, Priyanka Sharma.
Onco Targets Ther, 2017 Oct 17; 10. PMID: 29033586    Free PMC article.
Review.
Breast Cancer in Latinas: A Focus on Intrinsic Subtypes Distribution.
Silvia J Serrano-Gómez, Laura Fejerman, Jovanny Zabaleta.
Cancer Epidemiol Biomarkers Prev, 2017 Oct 22; 27(1). PMID: 29054978    Free PMC article.
Review.
Cellular subtype may predict survival outcomes in salivary adenoid cystic carcinoma patients-a single-institution experience.
Ehab Y Hanna, Ahmed S A Abdelmeguid, +3 authors, Diana Bell.
Virchows Arch, 2017 Oct 25; 472(3). PMID: 29063189
Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer.
Ariadna Giró-Perafita, Ariadna Sarrats, +5 authors, Teresa Puig Miquel.
Oncotarget, 2017 Nov 02; 8(43). PMID: 29088795    Free PMC article.
Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.
Charli Dominguez, Kristen K McCampbell, Justin M David, Claudia Palena.
JCI Insight, 2017 Nov 03; 2(21). PMID: 29093275    Free PMC article.
MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells.
Lourdes Sánchez-Cid, Mònica Pons, +20 authors, Timothy M Thomson.
Oncotarget, 2017 Nov 16; 8(48). PMID: 29137351    Free PMC article.
Nestin expression in breast cancer: association with prognosis and subtype on 3641 cases with long-term follow-up.
Karama Asleh, Jennifer R Won, +2 authors, Torsten O Nielsen.
Breast Cancer Res Treat, 2017 Nov 22; 168(1). PMID: 29159761    Free PMC article.
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.
Philipp Y Maximov, Balkees Abderrahman, +3 authors, V Craig Jordan.
Endocr Relat Cancer, 2017 Nov 23; 25(2). PMID: 29162647    Free PMC article.
Review.
Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice.
I Blancas, M Fontanillas, +17 authors, M Ruiz-Borrego.
Clin Transl Oncol, 2017 Nov 28; 20(7). PMID: 29178019
Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method.
Henri Wathieu, Naiem T Issa, +6 authors, Sivanesan Dakshanamurthy.
Oncotarget, 2017 Dec 02; 8(54). PMID: 29190967    Free PMC article.
Development and cytotoxic response of two proliferative MDA-MB-231 and non-proliferative SUM1315 three-dimensional cell culture models of triple-negative basal-like breast cancer cell lines.
Clémence Dubois, Robin Dufour, +6 authors, Mahchid Bamdad.
Oncotarget, 2017 Dec 10; 8(56). PMID: 29221130    Free PMC article.
Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity.
Elisabet Cuyàs, Sara Verdura, +4 authors, Javier A Menendez.
Oncotarget, 2017 Dec 17; 8(59). PMID: 29245896    Free PMC article.
Mammary stem cells: angels or demons in mammary gland?
Xueman Chen, Qiang Liu, Erwei Song.
Signal Transduct Target Ther, 2017 Dec 22; 2. PMID: 29263909    Free PMC article.
Review.
Protein biomarkers for subtyping breast cancer and implications for future research.
Claudius Mueller, Amanda Haymond, +2 authors, Virginia Espina.
Expert Rev Proteomics, 2017 Dec 23; 15(2). PMID: 29271260    Free PMC article.
Review.
FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.
Yetunde Ogunbolude, Chenlu Dai, +11 authors, Kiven Erique Lukong.
Oncotarget, 2018 Jan 20; 8(68). PMID: 29348886    Free PMC article.
Is Mastectomy Oncologically Safer than Breast-Conserving Treatment in Early Breast Cancer?
Fabian Riedel, André Hennigs, +5 authors, Jörg Heil.
Breast Care (Basel), 2018 Feb 20; 12(6). PMID: 29456470    Free PMC article.
Review.
Differential expression and clinical significance of epithelial-mesenchymal transition markers among different histological types of triple-negative breast cancer.
Shuling Zhou, Xiangjie Sun, +4 authors, Wentao Yang.
J Cancer, 2018 Feb 28; 9(3). PMID: 29483966    Free PMC article.
Establishment of two basal-like breast cancer cell lines with extremely low tumorigenicity from Taiwanese premenopausal women.
Wen-Ling Kuo, Shir-Hwa Ueng, +6 authors, Chi-Neu Tsai.
Hum Cell, 2018 Feb 28; 31(2). PMID: 29484537    Free PMC article.
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.
Pernilla Roswall, Matteo Bocci, +24 authors, Kristian Pietras.
Nat Med, 2018 Mar 13; 24(4). PMID: 29529015    Free PMC article.
Highly Cited.
KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer.
Jennifer F Knight, Vanessa Y C Sung, +18 authors, Morag Park.
Cell Rep, 2018 Mar 22; 22(12). PMID: 29562176    Free PMC article.
microRNA-10b expression and its correlation with molecular subtypes of early invasive ductal carcinoma.
Chenming Guo, Minggang Fu, +2 authors, Liying Guo.
Exp Ther Med, 2018 Mar 31; 15(3). PMID: 29599829    Free PMC article.
Update on the Treatment of Early-Stage Triple-Negative Breast Cancer.
Priyanka Sharma.
Curr Treat Options Oncol, 2018 Apr 16; 19(5). PMID: 29656345
Review.
Specific breast cancer prognosis-subtype distinctions based on DNA methylation patterns.
Shumei Zhang, Yihan Wang, +9 authors, Yan Zhang.
Mol Oncol, 2018 Apr 21; 12(7). PMID: 29675884    Free PMC article.
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Oihana Iriondo, Yarong Liu, +6 authors, Min Yu.
Nat Commun, 2018 May 20; 9(1). PMID: 29777109    Free PMC article.
Patient Similarity Networks for Precision Medicine.
Shraddha Pai, Gary D Bader.
J Mol Biol, 2018 Jun 04; 430(18 Pt A). PMID: 29860027    Free PMC article.
Review.
Basal-like Breast Cancers: From Pathology to Biology and Back Again.
Barry Gusterson, Connie J Eaves.
Stem Cell Reports, 2018 Jun 07; 10(6). PMID: 29874626    Free PMC article.
Review.
Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy.
Angela Santonja, Alfonso Sánchez-Muñoz, +18 authors, Emilio Alba.
Oncotarget, 2018 Jun 15; 9(41). PMID: 29899867    Free PMC article.
Classifying tumors by supervised network propagation.
Wei Zhang, Jianzhu Ma, Trey Ideker.
Bioinformatics, 2018 Jun 29; 34(13). PMID: 29949979    Free PMC article.
Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.
Alison Hirukawa, Harvey W Smith, +10 authors, William J Muller.
Nat Commun, 2018 Jul 01; 9(1). PMID: 29959321    Free PMC article.
Aryl Hydrocarbon Receptor Diet and Breast Cancer Risk.
Micah G Donovan, Ornella I Selmin, Donato F Romagnolo.
Yale J Biol Med, 2018 Jul 03; 91(2). PMID: 29962921    Free PMC article.
Review.
Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.
Ming Luo, Li Shang, +16 authors, Max S Wicha.
Cell Metab, 2018 Jul 05; 28(1). PMID: 29972798    Free PMC article.
Highly Cited.
Interleukin enhancer binding factor 2 is a prognostic biomarker for breast cancer that also predicts neoadjuvant chemotherapy responses.
Zining Jin, Lu Xu, +9 authors, Bo Chen.
Am J Transl Res, 2018 Jul 19; 10(6). PMID: 30018709    Free PMC article.
Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer.
Alec M Chiu, Mithun Mitra, Lari Boymoushakian, Hilary A Coller.
Sci Rep, 2018 Aug 09; 8(1). PMID: 30087365    Free PMC article.
Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression.
Harald Hessel, Manuela Poignée-Heger, +6 authors, Thomas Kirchner.
J Cancer, 2018 Aug 09; 9(15). PMID: 30087699    Free PMC article.
The Ras-related gene ERAS is involved in human and murine breast cancer.
Cristian Suárez-Cabrera, Bárbara de la Peña, +9 authors, Manuel Navarro.
Sci Rep, 2018 Aug 31; 8(1). PMID: 30158566    Free PMC article.
Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
Angela Flávia Logullo, Fatima Solange Pasini, +3 authors, Maria Mitzi Brentani.
Mol Clin Oncol, 2018 Sep 15; 9(4). PMID: 30214726    Free PMC article.
MicroRNAs and DNA-Damaging Drugs in Breast Cancer: Strength in Numbers.
Ilaria Plantamura, Giulia Cosentino, Alessandra Cataldo.
Front Oncol, 2018 Sep 21; 8. PMID: 30234015    Free PMC article.
Review.
Aurantoside C Targets and Induces Apoptosis in Triple Negative Breast Cancer Cells.
Sumi Shrestha, Anabel Sorolla, +2 authors, Gavin R Flematti.
Mar Drugs, 2018 Oct 03; 16(10). PMID: 30275391    Free PMC article.
High RNA-binding Motif Protein 3 Expression Is Associated with Improved Clinical Outcomes in Invasive Breast Cancer.
Sun Hee Kang, Jihyoung Cho, Hasong Jeong, Sun Young Kwon.
J Breast Cancer, 2018 Oct 03; 21(3). PMID: 30275857    Free PMC article.
A comprehensive overview of genomic imprinting in breast and its deregulation in cancer.
Tine Goovaerts, Sandra Steyaert, +4 authors, Tim De Meyer.
Nat Commun, 2018 Oct 10; 9(1). PMID: 30297886    Free PMC article.
Review.
Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2.
Steven J Tobin, Devin L Wakefield, +3 authors, Tijana Jovanović-Talisman.
Sci Rep, 2018 Oct 13; 8(1). PMID: 30310083    Free PMC article.
An Effect of Culture Media on Epithelial Differentiation Markers in Breast Cancer Cell Lines MCF7, MDA-MB-436 and SkBr3.
Valdis Pirsko, Inese Cakstina, +6 authors, Edvins Miklasevics.
Medicina (Kaunas), 2018 Oct 23; 54(2). PMID: 30344242    Free PMC article.
Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells.
Takeo Tatsuta, Shoko Sato, +4 authors, Masahiro Hosono.
Molecules, 2018 Oct 24; 23(10). PMID: 30347895    Free PMC article.
DNA Methylation Predicts the Response of Triple-Negative Breast Cancers to All-Trans Retinoic Acid.
Krysta Mila Coyle, Cheryl A Dean, +4 authors, Paola Marcato.
Cancers (Basel), 2018 Oct 26; 10(11). PMID: 30352973    Free PMC article.
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer.
Alexandra Thomas, Eric D Routh, +17 authors, Lance D Miller.
Oncoimmunology, 2018 Nov 06; 7(10). PMID: 30386679    Free PMC article.
Highly Cited.
Ixazomib in combination with carboplatin in pretreated women with advanced triple-negative breast cancer, a phase I/II trial of the AGMT (AGMT MBC-10 trial).
Gabriel Rinnerthaler, Simon Peter Gampenrieder, +13 authors, Richard Greil.
BMC Cancer, 2018 Nov 08; 18(1). PMID: 30400780    Free PMC article.
Breast cancer stem cells and the challenges of eradication: a review of novel therapies.
Fouad Saeg, Muralidharan Anbalagan.
Stem Cell Investig, 2018 Dec 01; 5. PMID: 30498750    Free PMC article.
Review.
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.
Stephin J Vervoort, Olivier G de Jong, +19 authors, Paul J Coffer.
Elife, 2018 Dec 06; 7. PMID: 30507376    Free PMC article.
Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis.
Silvia Mihaela Ilie, Xenia Elena Bacinschi, Inga Botnariuc, Rodica Maricela Anghel.
Breast Cancer (Dove Med Press), 2018 Dec 13; 10. PMID: 30538542    Free PMC article.
Incidence and prognostic factors of patients with synchronous liver metastases upon initial diagnosis of breast cancer: a population-based study.
Hai-Yun Zhao, Yue Gong, +2 authors, Xin Hu.
Cancer Manag Res, 2018 Dec 13; 10. PMID: 30538544    Free PMC article.
Mindfulness-Based Stress Reduction on breast cancer symptoms: systematic review and meta-analysis.
Flavia Del Castanhel, Rafaela Liberali.
Einstein (Sao Paulo), 2018 Dec 13; 16(4). PMID: 30540032    Free PMC article.
Systematic Review.
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BMC Cancer, 2019 Dec 01; 19(1). PMID: 31783818    Free PMC article.
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Front Oncol, 2019 Dec 13; 9. PMID: 31828042    Free PMC article.
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A Pathology-Based Combined Model to Identify PAM50 Non-luminal Intrinsic Disease in Hormone Receptor-Positive HER2-Negative Breast Cancer.
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A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements.
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Antrodia cinnamomea, a Treasured Medicinal Mushroom, Induces Growth Arrest in Breast Cancer Cells, T47D Cells: New Mechanisms Emerge.
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