Molecular profiling currently offers no more than tumour morphology and basic immunohistochemistry

Britta Weigelt ¹, Jorge S Reis-Filho

Affiliations

¹ Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.

PMID: 21172089
47 References
27 citations

No abstract available

Other Links

Free PMC article
Full text on Breast cancer research : BCR

References
Cited By

References
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver. less Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700 Free PMC article. Highly Cited.
Gene expression profiling of breast cancer: a new tumor marker. Laura J van't Veer, Soonmyung Paik, Daniel F Hayes. J Clin Oncol, 2005 Mar 10; 23(8). PMID: 15755970 Review.
The molecular portraits of breast tumors are conserved across microarray platforms. Zhiyuan Hu, Cheng Fan, +28 authors, Charles M Perou. less BMC Genomics, 2006 Apr 29; 7. PMID: 16643655 Free PMC article. Highly Cited.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark. less J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680 Highly Cited.
Concordance among gene-expression-based predictors for breast cancer. Cheng Fan, Daniel S Oh, +5 authors, Charles M Perou. less N Engl J Med, 2006 Aug 11; 355(6). PMID: 16899776 Highly Cited.
Molecular classification of breast cancer: limitations and potential. Lajos Pusztai, Chafika Mazouni, +2 authors, Keith Anderson, Yun Wu, W Fraser Symmans. less Oncologist, 2006 Sep 05; 11(8). PMID: 16951390 Review.
Technology Insight: tuning into the genetic orchestra using microarrays--limitations of DNA microarrays in clinical practice. Ambreen Abdullah-Sayani, Jolien M Bueno-de-Mesquita, Marc J van de Vijver. Nat Clin Pract Oncol, 2006 Sep 07; 3(9). PMID: 16955089 Review.
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Anna V Ivshina, Joshy George, +12 authors, Lance D Miller. less Cancer Res, 2006 Nov 03; 66(21). PMID: 17079448 Highly Cited.
Gene expression profiling: does it add predictive accuracy to clinical characteristics in cancer prognosis? Daniela Dunkler, Stefan Michiels, Michael Schemper. Eur J Cancer, 2007 Jan 30; 43(4). PMID: 17257824
Interpretation of microarray data in cancer. S Michiels, S Koscielny, C Hill. Br J Cancer, 2007 Mar 08; 96(8). PMID: 17342085 Free PMC article. Review.
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Christine Desmedt, Fanny Piette, +18 authors, TRANSBIG Consortium. less Clin Cancer Res, 2007 Jun 05; 13(11). PMID: 17545524 Highly Cited.
Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Christos Sotiriou, Martine J Piccart. Nat Rev Cancer, 2007 Jun 23; 7(7). PMID: 17585334 Highly Cited. Review.
Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen. Soonmyung Paik. Oncologist, 2007 Jul 03; 12(6). PMID: 17602054
Challenges in projecting clustering results across gene expression-profiling datasets. Lara Lusa, Lisa M McShane, +5 authors, Marco A Pierotti. less J Natl Cancer Inst, 2007 Nov 15; 99(22). PMID: 18000217
Molecular subtypes in breast cancer evaluation and management: divide and conquer. Jeffrey Peppercorn, Charles M Perou, Lisa A Carey. Cancer Invest, 2008 Jan 09; 26(1). PMID: 18181038 Review.
Enabling personalized cancer medicine through analysis of gene-expression patterns. Laura J van't Veer, René Bernards. Nature, 2008 Apr 04; 452(7187). PMID: 18385730 Highly Cited. Review.
Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes. Christine Desmedt, Benjamin Haibe-Kains, +6 authors, Christos Sotiriou. less Clin Cancer Res, 2008 Aug 14; 14(16). PMID: 18698033 Highly Cited.
Refinement of breast cancer classification by molecular characterization of histological special types. B Weigelt, H M Horlings, +7 authors, J L Peterse. less J Pathol, 2008 Aug 23; 216(2). PMID: 18720457 Highly Cited.
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Pratyaksha Wirapati, Christos Sotiriou, +10 authors, Mauro Delorenzi. less Breast Cancer Res, 2008 Jul 30; 10(4). PMID: 18662380 Free PMC article. Highly Cited.
Gene-expression signatures in breast cancer. Christos Sotiriou, Lajos Pusztai. N Engl J Med, 2009 Feb 21; 360(8). PMID: 19228622 Highly Cited. Review.
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer. Fabien Reyal, Martin H van Vliet, +10 authors, Lodewyk F A Wessels. less Breast Cancer Res, 2008 Nov 19; 10(6). PMID: 19014521 Free PMC article.
Supervised risk predictor of breast cancer based on intrinsic subtypes. Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard. less J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204 Free PMC article. Highly Cited.
Microarray-based gene expression profiling as a clinical tool for breast cancer management: are we there yet? Felipe Correa Geyer, Jorge Sergio Reis-Filho. Int J Surg Pathol, 2008 Dec 24; 17(4). PMID: 19103611 Review.
Calibration and discriminatory accuracy of prognosis calculation for breast cancer with the online Adjuvant! program: a hospital-based retrospective cohort study. Stella Mook, Marjanka K Schmidt, +6 authors, Peter M Ravdin. less Lancet Oncol, 2009 Oct 06; 10(11). PMID: 19801202
Histological and molecular types of breast cancer: is there a unifying taxonomy? Britta Weigelt, Jorge S Reis-Filho. Nat Rev Clin Oncol, 2009 Nov 28; 6(12). PMID: 19942925 Highly Cited. Review.
Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response. Jorma J de Ronde, Juliane Hannemann, +7 authors, Sjoerd Rodenhuis. less Breast Cancer Res Treat, 2009 Aug 12; 119(1). PMID: 19669409
The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type. Britta Weigelt, Felipe C Geyer, +5 authors, Jorge S Reis-Filho. less J Pathol, 2009 Oct 31; 220(1). PMID: 19877120
Does massively parallel DNA resequencing signify the end of histopathology as we know it? Samuel A J R Aparicio, David G Huntsman. J Pathol, 2009 Nov 19; 220(2). PMID: 19921711 Review.
The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. Britta Weigelt, Frederick L Baehner, Jorge S Reis-Filho. J Pathol, 2009 Nov 21; 220(2). PMID: 19927298 Highly Cited. Review.
Next-generation sequencing. Jorge S Reis-Filho. Breast Cancer Res, 2010 Jan 20; 11 Suppl 3. PMID: 20030863 Free PMC article.
Breast cancer molecular profiling with single sample predictors: a retrospective analysis. Britta Weigelt, Alan Mackay, +5 authors, Jorge S Reis-Filho. less Lancet Oncol, 2010 Feb 26; 11(4). PMID: 20181526 Highly Cited.
Gene-expression-based prognostic assays for breast cancer. Chungyeul Kim, Soonmyung Paik. Nat Rev Clin Oncol, 2010 May 05; 7(6). PMID: 20440284 Review.
Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas. Maria A Lopez-Garcia, Felipe C Geyer, +5 authors, Britta Weigelt. less J Pathol, 2010 Jul 02; 222(1). PMID: 20593406
Disparities in breast cancer mortality trends between 30 European countries: retrospective trend analysis of WHO mortality database. Philippe Autier, Mathieu Boniol, +5 authors, Mary Heanue. less BMJ, 2010 Aug 13; 341. PMID: 20702548 Free PMC article. Highly Cited.
Molecular portraits of human breast tumours. C M Perou, T Sørlie, +15 authors, D Botstein. less Nature, 2000 Aug 30; 406(6797). PMID: 10963602 Highly Cited.
Does massively parallel transcriptome analysis signify the end of cancer histopathology as we know it? S A Aparicio, C Caldas, B Ponder. Genome Biol, 2001 Feb 24; 1(3). PMID: 11178245 Free PMC article. Review.
Microarrays--the 21st century divining rod? Y D He, S H Friend. Nat Med, 2001 Jun 01; 7(6). PMID: 11385496
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. T Sørlie, C M Perou, +14 authors, A L Børresen-Dale. less Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815 Free PMC article. Highly Cited.
Gene expression profiling predicts clinical outcome of breast cancer. Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend. less Nature, 2002 Feb 02; 415(6871). PMID: 11823860 Highly Cited.
A gene-expression signature as a predictor of survival in breast cancer. Marc J van de Vijver, Yudong D He, +18 authors, René Bernards. less N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681 Highly Cited.
Repeated observation of breast tumor subtypes in independent gene expression data sets. Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein. less Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800 Free PMC article. Highly Cited.
Predictive cancer genomics--what do we need? James D Brenton, Carlos Caldas. Lancet, 2003 Aug 09; 362(9381). PMID: 12907001
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark. less N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335 Highly Cited.
Outcome signature genes in breast cancer: is there a unique set? Liat Ein-Dor, Itai Kela, +2 authors, Gad Getz, David Givol, Eytan Domany. less Bioinformatics, 2004 Aug 17; 21(2). PMID: 15308542 Highly Cited.
Microarrays and molecular research: noise discovery? John P A Ioannidis. Lancet, 2005 Feb 12; 365(9458). PMID: 15705441
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Yixin Wang, Jan G M Klijn, +11 authors, John A Foekens. less Lancet, 2005 Feb 22; 365(9460). PMID: 15721472 Highly Cited.
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. Christos Sotiriou, Pratyaksha Wirapati, +17 authors, Mauro Delorenzi. less J Natl Cancer Inst, 2006 Feb 16; 98(4). PMID: 16478745 Highly Cited.

Citedby
Revisiting the technical validation of tumour biomarker assays: how to open a Pandora's box. Caterina Marchiò, Mitch Dowsett, Jorge S Reis-Filho. BMC Med, 2011 Apr 21; 9. PMID: 21504565 Free PMC article. Review.
Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki-67 and p53. E K A Millar, P H Graham, +10 authors, R L Sutherland. less Br J Cancer, 2011 Jun 30; 105(2). PMID: 21712826 Free PMC article.
Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction. Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho. Breast Cancer Res, 2011 Jul 27; 13(3). PMID: 21787441 Free PMC article. Review.
Challenges translating breast cancer gene signatures into the clinic. Britta Weigelt, Lajos Pusztai, Alan Ashworth, Jorge S Reis-Filho. Nat Rev Clin Oncol, 2011 Sep 01; 9(1). PMID: 21878891 Review.
Multi-field-of-view strategy for image-based outcome prediction of multi-parametric estrogen receptor-positive breast cancer histopathology: Comparison to Oncotype DX. Ajay Basavanhally, Michael Feldman, +4 authors, Anant Madabhushi. less J Pathol Inform, 2011 Jan 01; 2. PMID: 22811953 Free PMC article.
Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population. Chi-Cheng Huang, Shih-Hsin Tu, +7 authors, Eric Y Chuang. less J Transl Med, 2012 Oct 25; 10 Suppl 1. PMID: 23046482 Free PMC article.
Transcriptional shift identifies a set of genes driving breast cancer chemoresistance. Laura Vera-Ramirez, Pedro Sanchez-Rovira, +3 authors, Jose A Lorente. less PLoS One, 2013 Jan 18; 8(1). PMID: 23326553 Free PMC article.
Multi-field-of-view framework for distinguishing tumor grade in ER+ breast cancer from entire histopathology slides. Ajay Basavanhally, Shridar Ganesan, +4 authors, Anant Madabhushi. less IEEE Trans Biomed Eng, 2013 Feb 09; 60(8). PMID: 23392336 Free PMC article.
Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers. Xianxiao Zhou, Tongwei Shi, +6 authors, Zheng Guo. less PLoS One, 2013 Jul 23; 8(7). PMID: 23875016 Free PMC article.
Infrequent loss of luminal differentiation in ductal breast cancer metastasis. Julia Calvo, Lourdes Sánchez-Cid, +3 authors, Pedro L Fernández. less PLoS One, 2013 Nov 10; 8(10). PMID: 24205108 Free PMC article.
Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics. Carol Sweeney, Philip S Bernard, +11 authors, Bette J Caan. less Cancer Epidemiol Biomarkers Prev, 2014 Feb 14; 23(5). PMID: 24521995 Free PMC article.
Molecular markers for breast cancer: prediction on tumor behavior. Bruna Karina Banin Hirata, Julie Massayo Maeda Oda, +3 authors, Maria Angelica Ehara Watanabe. less Dis Markers, 2014 Mar 05; 2014. PMID: 24591761 Free PMC article. Review.
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility. P Sinn, S Aulmann, +6 authors, A Schneeweiss. less Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(9). PMID: 24771945 Free PMC article.
FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer. Leandra Fiori Lopes, Roberta Losi Guembarovski, +7 authors, Maria Angelica Ehara Watanabe. less Biomed Res Int, 2014 May 31; 2014. PMID: 24877082 Free PMC article.
The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma. Rocío Montes de Oca, Zachary A Gurard-Levin, +12 authors, Geneviève Almouzni. less Mol Oncol, 2014 Dec 17; 9(3). PMID: 25497280 Free PMC article.
New breast cancer prognostic factors identified by computer-aided image analysis of HE stained histopathology images. Jia-Mei Chen, Ai-Ping Qu, +7 authors, Yan Li. less Sci Rep, 2015 May 30; 5. PMID: 26022540 Free PMC article.
Immunoprofile from tissue microarrays to stratify familial breast cancer patients. Laura Schirosi, Simona De Summa, +5 authors, Anita Mangia. less Oncotarget, 2015 Aug 28; 6(29). PMID: 26312763 Free PMC article.
Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications. Vida Pourteimoor, Samira Mohammadi-Yeganeh, Mahdi Paryan. Tumour Biol, 2016 Sep 22; 37(11). PMID: 27651157 Review.
Prognostic contribution of mammographic breast density and HER2 overexpression to the Nottingham Prognostic Index in patients with invasive breast cancer. Amro Masarwah, Päivi Auvinen, +6 authors, Ritva Vanninen. less BMC Cancer, 2016 Nov 04; 16(1). PMID: 27806715 Free PMC article.
Variation-preserving normalization unveils blind spots in gene expression profiling. Carlos P Roca, Susana I L Gomes, Mónica J B Amorim, Janeck J Scott-Fordsmand. Sci Rep, 2017 Mar 10; 7. PMID: 28276435 Free PMC article.
HER2 Ile655Val polymorphism is negatively associated with breast cancer susceptibility. Felipe Campos de Almeida, Bruna Karina Banin Hirata, +7 authors, Maria Angelica Ehara Watanabe. less J Clin Lab Anal, 2018 Feb 09; 32(6). PMID: 29417620 Free PMC article.
Androgen Receptor Expression in Breast Cancer: What Differences Between Primary Tumor and Metastases? Giuseppe Bronte, Sara Bravaccini, +12 authors, Andrea Rocca. less Transl Oncol, 2018 Jun 12; 11(4). PMID: 29890379 Free PMC article.
Correlation of Serum Levels of Urokinase Activation Plasminogen (uPA) and Its Inhibitor (PAI-1) with Hormonal and HER-2 Status in the Early Invasive Breast Cancer. Sadat Pusina. Med Arch, 2018 Dec 14; 72(5). PMID: 30524164 Free PMC article.
Prognostic Values Of Preoperative Serum CEA And CA125 Levels And Nomograms For Young Breast Cancer Patients. Xuan Li, Danian Dai, +4 authors, Bin Wang. less Onco Targets Ther, 2019 Nov 07; 12. PMID: 31695434 Free PMC article.
Drug repurposing for breast cancer therapy: Old weapon for new battle. Sadhna Aggarwal, Sumit Singh Verma, Sumit Aggarwal, Subash Chandra Gupta. Semin Cancer Biol, 2019 Sep 25; 68. PMID: 31550502 Free PMC article. Review.
Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association. Famke Aeffner, Mark D Zarella, +11 authors, Douglas Bowman. less J Pathol Inform, 2019 Apr 16; 10. PMID: 30984469 Free PMC article. Highly Cited. Review.
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. Maria Karmella Apaya, Jeng-Yuan Shiau, +6 authors, Lie-Fen Shyur. less J Exp Clin Cancer Res, 2019 May 11; 38(1). PMID: 31072371 Free PMC article.

BioKDE: Biomedical Knowledge Discovery Engine

No abstract available

Other Links