Journal Article
. 2011 Jan;5(12).
doi: 10.1371/journal.pone.0015903.

Postoperative fever: the potential relationship with prognosis in node negative breast cancer patients

Tingting Yan 1 Wenjin Yin  Liheng Zhou  Yiwei Jiang  Zhenzhou Shen  Zhimin Shao  Jinsong Lu  
Affiliations
  • PMID: 21209958
  •     31 References
  •     3 citations

Abstract

Background: Postoperative fever may serve as an indirect sign to reflect the alterations of the host milieu caused by surgery. It still remains open to investigation whether postoperative fever has a bearing on prognosis in patients with lymph node negative breast cancers.

Methods: We performed a retrospective study of 883 female unilateral patients with lymph node negative breast cancer. Fever was defined as an oral temperature ≥38 in one week postoperation. Survival curves were performed with Kaplan-Meier method, and annual relapse hazard was estimated by hazard function.

Findings: The fever patients were older than those without fever (P<0.0001). Hypertensive patients had a propensity for fever after surgery (P = 0.011). A statistically significant difference was yielded in the incidence of fever among HR+/ERBB2-, ERBB2+, HR-/ERBB2- subgroups (P = 0.012). In the univariate survival analysis, we observed postoperative fever patients were more likely to recur than those without fever (P = 0.0027). The Cox proportional hazards regression analysis showed that postoperative fever (P = 0.044, RR = 1.89, 95%CI 1.02-3.52) as well as the HR/ERBB2 subgroups (P = 0.013, HR = 1.60, 95%CI 1.09-2.31) was an independent prognostic factor for relapse-free survival.

Conclusion: Postoperative fever may contribute to relapse in node negative breast cancer patients, which suggests that changes in host milieu related to fever might accelerate the growth of micro-metastatic foci. It may be more precise to integrate both tumor- and host-related factors for the evaluation of relapse risk.

The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer.
Shelley B Bull, Hilmi Ozcelik, +11 authors, Irene L Andrulis.
J Clin Oncol, 2004 Jan 01; 22(1). PMID: 14701769
Cancer incidence in five continents. Volume VIII.
IARC Sci Publ, 2003 Jun 19; (155). PMID: 12812229
Cytokines and fever.
Bruno Conti, Iustin Tabarean, Cristina Andrei, Tamas Bartfai.
Front Biosci, 2004 Feb 24; 9. PMID: 14977558
Review.
The full potential of breast cancer screening use to reduce mortality has not yet been realized in the United States.
Mario Schootman, Donna Jeffe, Anat Reschke, Rebecca Aft.
Breast Cancer Res Treat, 2004 Apr 28; 85(3). PMID: 15111759
Decreased rates of advanced breast cancer due to mammography screening in The Netherlands.
J Fracheboud, S J Otto, +4 authors, National Evaluation Team for Breast cancer screening (NETB).
Br J Cancer, 2004 Aug 05; 91(5). PMID: 15292936    Free PMC article.
The strongest prognostic factors in colorectal carcinoma. Surgicopathologic stage of disease and postoperative fever.
M P Nowacki, J J Szymendera.
Dis Colon Rectum, 1983 Apr 01; 26(4). PMID: 6839898
[Postoperative fever and prognosis in breast cancer].
G Teucher, A E Schindler.
Arch Geschwulstforsch, 1987 Jan 01; 57(4). PMID: 3675144
Presence of a growth-stimulating factor in serum following primary tumor removal in mice.
B Fisher, N Gunduz, +2 authors, E Saffer.
Cancer Res, 1989 Apr 15; 49(8). PMID: 2702641
Highly Cited.
Trauma-induced alterations in macrophage function.
M D McCarter, V E Mack, +2 authors, S E Calvano.
Surgery, 1998 Feb 11; 123(1). PMID: 9457229
Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma.
G J Zhang, I Adachi.
Anticancer Res, 1999 Jun 12; 19(2B). PMID: 10365118
Highly Cited.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Gene expression profiling of breast cancer: a new tumor marker.
Laura J van't Veer, Soonmyung Paik, Daniel F Hayes.
J Clin Oncol, 2005 Mar 10; 23(8). PMID: 15755970
Review.
Evaluating postoperative fever: a focused approach.
James C Pile.
Cleve Clin J Med, 2006 Mar 31; 73 Suppl 1. PMID: 16570551
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients.
Laurel A Habel, Steven Shak, +12 authors, Charles P Quesenberry.
Breast Cancer Res, 2006 Jun 02; 8(3). PMID: 16737553    Free PMC article.
Highly Cited.
Cytokine secretion after cardiac surgery and its relationship to postoperative fever.
John D Mitchell, Hilary P Grocott, +3 authors, Shahar Bar-Yosef.
Cytokine, 2007 Jun 19; 38(1). PMID: 17572096
Postoperative wound complications and systemic recurrence in breast cancer.
B L Murthy, C S Thomson, +4 authors, K Horgan.
Br J Cancer, 2007 Oct 31; 97(9). PMID: 17968426    Free PMC article.
An observational study to know the association of leukocytosis and fever with infection in post cardiac surgery patients.
Satish Kumar, Yatin Mehta, +3 authors, Naresh Trehan.
Indian Heart J, 2007 Jul 01; 59(4). PMID: 19126936
Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis.
Johanna R Reed, Ronald P Leon, Majken K Hall, Kathryn L Schwertfeger.
Breast Cancer Res, 2009 Apr 28; 11(2). PMID: 19393083    Free PMC article.
Cancer statistics, 2009.
Ahmedin Jemal, Rebecca Siegel, +3 authors, Michael J Thun.
CA Cancer J Clin, 2009 May 29; 59(4). PMID: 19474385
Highly Cited.
Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009.
A Goldhirsch, J N Ingle, +4 authors, Panel members.
Ann Oncol, 2009 Jun 19; 20(8). PMID: 19535820    Free PMC article.
Highly Cited.
Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice.
Mary Ann Warren, Suzanne F Shoemaker, +2 authors, Margot M Ip.
Mol Cancer Ther, 2009 Sep 17; 8(9). PMID: 19755514
Anesthesia and the microcirculation.
Zdenek Turek, Roman Sykora, Martin Matejovic, Vladimir Cerny.
Semin Cardiothorac Vasc Anesth, 2009 Dec 05; 13(4). PMID: 19959497
Review.
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene.
Shuai Jiang, Hong-Wei Zhang, +5 authors, En-Duo Wang.
Cancer Res, 2010 Apr 01; 70(8). PMID: 20354188
Highly Cited.
Whole blood tumor necrosis factor-alpha production and its relation to systemic concentrations of interleukin 4, interleukin 10, and transforming growth factor-beta1 in multiply injured blunt trauma victims.
M Majetschak, J Börgermann, +3 authors, F U Schade.
Crit Care Med, 2000 Jul 13; 28(6). PMID: 10890631
Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years.
Attiqa N Mirza, Nadeem Q Mirza, Georges Vlastos, S Eva Singletary.
Ann Surg, 2001 Dec 26; 235(1). PMID: 11753038    Free PMC article.
Review.
Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.
D Conze, L Weiss, +4 authors, M Rincón.
Cancer Res, 2001 Dec 26; 61(24). PMID: 11751408
Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975-1999.
Pamela M Vacek, Berta M Geller, Donald L Weaver, Roger S Foster.
Cancer, 2002 May 10; 94(8). PMID: 12001112
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.
Isaiah J Fidler.
Nat Rev Cancer, 2003 Jun 05; 3(6). PMID: 12778135
Highly Cited.
Fever as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation.
S Michael Marcy, Katrin S Kohl, +11 authors, Brighton Collaboration Fever Working Group.
Vaccine, 2004 Jan 27; 22(5-6). PMID: 14741143
Review.
Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.
Dongwei Gao, Sha Li.
Pathol Oncol Res, 2013 Dec 21; 20(1). PMID: 24357158
Review.
Postoperative fever predicts poor prognosis of gastric cancer.
Fan Feng, Yangzi Tian, +7 authors, Hongwei Zhang.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977974    Free PMC article.
LncRNA MALAT1 promotes relapse of breast cancer patients with postoperative fever.
Zhihua Li, Liang Xu, +4 authors, Qiuyun Xiong.
Am J Transl Res, 2018 Nov 13; 10(10). PMID: 30416660    Free PMC article.