Journal Article
. 2011 Apr; 6 Suppl 1:S12.
doi: 10.1186/1746-1596-6-s1-s12.

Grid computing in image analysis

Klaus Kayser 1 Jürgen Görtler  Stephan Borkenfeld  Gian Kayser  
Affiliations
  • PMID: 21516880
  •     23 References
  •     4 citations

Abstract

Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides and to work on so-called virtual microscopes. In addition to interactive work on virtual slides approaches have been reported that introduce automated virtual microscopy, which is composed of several tools focusing on quite different tasks. These include evaluation of image quality and image standardization, analysis of potential useful thresholds for object detection and identification (segmentation), dynamic segmentation procedures, adjustable magnification to optimize feature extraction, and texture analysis including image transformation and evaluation of elementary primitives. Grid technology seems to possess all features to efficiently target and control the specific tasks of image information and detection in order to obtain a detailed and accurate diagnosis. Grid technology is based upon so-called nodes that are linked together and share certain communication rules in using open standards. Their number and functionality can vary according to the needs of a specific user at a given point in time. When implementing automated virtual microscopy with Grid technology, all of the five different Grid functions have to be taken into account, namely 1) computation services, 2) data services, 3) application services, 4) information services, and 5) knowledge services. Although all mandatory tools of automated virtual microscopy can be implemented in a closed or standardized open system, Grid technology offers a new dimension to acquire, detect, classify, and distribute medical image information, and to assure quality in tissue–based diagnosis.

A European network for virtual microscopy--design, implementation and evaluation of performance.
Mikael Lundin, Janusz Szymas, +11 authors, Johan Lundin.
Virchows Arch, 2009 Mar 13; 454(4). PMID: 19280223
Web-based virtual microscopy at the RWTH Aachen University: didactic concept, methods and analysis of acceptance by the students.
Magdalene Merk, Ruth Knuechel, Alberto Perez-Bouza.
Ann Anat, 2010 Apr 07; 192(6). PMID: 20363112
Simulation of emission tomography using grid middleware for distributed computing.
M G Thomason, R F Longton, +2 authors, R K Hutson.
Comput Methods Programs Biomed, 2004 Jul 22; 75(3). PMID: 15265623
Virtual microscopy and digital cytology: state of the art.
Daniele Giansanti, Mauro Grigioni, +4 authors, Maria Rosaria Giovagnoli.
Ann Ist Super Sanita, 2010 Jun 23; 46(2). PMID: 20567061
The use of virtual microscopy for proficiency testing in gynecologic cytopathology: a feasibility study using ScanScope.
Alberto M Marchevsky, Renu Khurana, +3 authors, Shika Bose.
Arch Pathol Lab Med, 2006 Mar 08; 130(3). PMID: 16519563
Image processing methods and architectures in diagnostic pathology.
Gloria Bueno, Oscar Déniz, Jesús Salido, Marcial García Rojo.
Folia Histochem Cytobiol, 2009 Jan 01; 47(4). PMID: 20430740
Theory of sampling and its application in tissue based diagnosis.
Klaus Kayser, Holger Schultz, +3 authors, Ekkehard Vollmer.
Diagn Pathol, 2009 Feb 18; 4. PMID: 19220904    Free PMC article.
Issues for application of virtual microscopy to cytoscreening, perspectives based on questionnaire to Japanese cytotechnologists.
Ichiro Mori, Osamu Nunobiki, +2 authors, Kennichi Kakudo.
Diagn Pathol, 2008 Aug 05; 3 Suppl 1. PMID: 18673503    Free PMC article.
Towards an automated virtual slide screening: theoretical considerations and practical experiences of automated tissue-based virtual diagnosis to be implemented in the Internet.
Klaus Kayser, Dominik Radziszowski, +2 authors, Gian Kayser.
Diagn Pathol, 2006 Jun 13; 1. PMID: 16764733    Free PMC article.
AI (artificial intelligence) in histopathology--from image analysis to automated diagnosis.
Klaus Kayser, Jürgen Görtler, +4 authors, Gian Kayser.
Folia Histochem Cytobiol, 2010 Feb 19; 47(3). PMID: 20164018
Review.
Texture- and object-related automated information analysis in histological still images of various organs.
Klaus Kayser, Sabah Amir Hoshang, +6 authors, Gian Kayser.
Anal Quant Cytol Histol, 2009 Jan 24; 30(6). PMID: 19160697
CheckDen, a program to compute quantum molecular properties on spatial grids.
Luis F Pacios, Alberto Fernandez.
J Mol Graph Model, 2009 May 19; 28(2). PMID: 19447056
Digitized pathology: theory and experiences in automated tissue-based virtual diagnosis.
K Kayser, D Radziszowski, +2 authors, G Kayser.
Rom J Morphol Embryol, 2006 Jul 14; 47(1). PMID: 16838053
Virtual microscopy and grid-enabled decision support for large-scale analysis of imaged pathology specimens.
Lin Yang, Wenjin Chen, +4 authors, David J Foran.
IEEE Trans Inf Technol Biomed, 2009 Apr 17; 13(4). PMID: 19369162    Free PMC article.
Grid requirements for the integration of biomedical information resources for health applications.
I C Oliveira, J L Oliveira, +4 authors, A Sousa Pereira.
Methods Inf Med, 2005 Jun 01; 44(2). PMID: 15924167
Histology, imaging and new diagnostic work-flows in pathology.
John Gilbertson, Yukako Yagi.
Diagn Pathol, 2008 Aug 05; 3 Suppl 1. PMID: 18673502    Free PMC article.
Automated region of interest retrieval and classification using spectral analysis.
Myriam Oger, Philippe Belhomme, +2 authors, Abderrahim Elmoataz.
Diagn Pathol, 2008 Aug 05; 3 Suppl 1. PMID: 18673505    Free PMC article.
Virtual histology by means of high-resolution X-ray CT.
V Cnudde, B Masschaele, +7 authors, P Jacobs.
J Microsc, 2008 Dec 20; 232(3). PMID: 19094024
Innovations in medical imaging and virtual microscopy.
Ronald S Weinstein.
Hum Pathol, 2005 May 14; 36(4). PMID: 15891989
Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slides.
Gian Kayser, Dominik Radziszowski, +2 authors, Klaus Kayser.
Anal Quant Cytol Histol, 2006 Mar 29; 28(1). PMID: 16566277
Towards improved diagnosis of zoonotic trematode infections in Southeast Asia.
Maria Vang Johansen, Paiboon Sithithaworn, Robert Bergquist, Jürg Utzinger.
Adv Parasitol, 2010 Jul 16; 73. PMID: 20627143
Review.
Grid technology in tissue-based diagnosis: fundamentals and potential developments.
Jürgen Görtler, Martin Berghoff, Gian Kayser, Klaus Kayser.
Diagn Pathol, 2006 Aug 26; 1. PMID: 16930477    Free PMC article.
GPCALMA: a Grid-based tool for mammographic screening.
P Cerello, S Bagnasco, +18 authors, E Zanon.
Methods Inf Med, 2005 Jun 01; 44(2). PMID: 15924184
Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
Jason Hipp, Thomas Flotte, +12 authors, Ulysses J Balis.
J Pathol Inform, 2011 Jul 21; 2. PMID: 21773056    Free PMC article.
Analyzing huge pathology images with open source software.
Christophe Deroulers, David Ameisen, +3 authors, Marc Lartaud.
Diagn Pathol, 2013 Jul 09; 8. PMID: 23829479    Free PMC article.
The history of pathology informatics: A global perspective.
Seung Park, Anil V Parwani, +15 authors, Liron Pantanowitz.
J Pathol Inform, 2013 Jul 23; 4. PMID: 23869286    Free PMC article.
Search for β2 adrenergic receptor ligands by virtual screening via grid computing and investigation of binding modes by docking and molecular dynamics simulations.
Qifeng Bai, Yonghua Shao, +3 authors, Xiaojun Yao.
PLoS One, 2014 Sep 18; 9(9). PMID: 25229694    Free PMC article.