Journal Article
. 2011 May;16(6).
doi: 10.1634/theoncologist.2010-0266.

Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients

Ian K Komenaka 1 Chiu-Hsieh Hsu  Maria Elena Martinez  Marcia E Bouton  Boo Ghee Low  Jason A Salganick  Jesse Nodora  Michael L Hibbard  Chandra Jha  
Affiliations
  • PMID: 21558134
  •     29 References
  •     5 citations

Abstract

Introduction: Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting.

Methods: Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated.

Results: There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100% versus 70%; p = .0001). Similarly, more patients in the PC group completed radiation therapy (96% versus 65%; p = .0003) and initiated hormonal therapy (100% versus 62%; p = .0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy.

Conclusions: PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.

Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
Kathy S Albain, William E Barlow, +20 authors, Breast Cancer Intergroup of North America.
Lancet Oncol, 2009 Dec 17; 11(1). PMID: 20005174    Free PMC article.
Highly Cited.
Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer.
Judy C Boughey, Florentia Peintinger, +9 authors, Henry M Kuerer.
Ann Surg, 2006 Aug 24; 244(3). PMID: 16926572    Free PMC article.
A breast center review of compliance with National Comprehensive Cancer Network Breast Cancer guidelines.
Jeffrey Landercasper, Leah L Dietrich, Jeanne M Johnson.
Am J Surg, 2006 Sep 19; 192(4). PMID: 16978966
Lost opportunities: physicians' reasons and disparities in breast cancer treatment.
Nina A Bickell, Felice LePar, Jason J Wang, Howard Leventhal.
J Clin Oncol, 2007 Jun 20; 25(18). PMID: 17577028
Adherence to bisphosphonate treatment by elderly women.
Janneke Berecki-Gisolf, Richard Hockey, Annette Dobson.
Menopause, 2008 Jun 04; 15(5). PMID: 18520695
Noncompliance with adjuvant radiation, chemotherapy, or hormonal therapy in breast cancer patients.
Aye Moe Thu Ma, Julie Barone, +5 authors, Paul Ian Tartter.
Am J Surg, 2008 Sep 24; 196(4). PMID: 18809051
Race and ethnicity and breast cancer outcomes in an underinsured population.
Ian K Komenaka, Maria Elena Martinez, +6 authors, Robert J Goulet.
J Natl Cancer Inst, 2010 Jun 25; 102(15). PMID: 20574040
A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy.
Yiing Lin, Shin Lin, +6 authors, Rebecca L Aft.
Breast Cancer Res Treat, 2009 Dec 08; 123(3). PMID: 19967557    Free PMC article.
Compliance differences between patients with breast cancer in university and county hospitals.
Ian K Komenaka, Robert E Pennington, +5 authors, Robert J Goulet.
Clin Breast Cancer, 2010 Oct 06; 10(5). PMID: 20920983
Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18.
N Wolmark, J Wang, +2 authors, B Fisher.
J Natl Cancer Inst Monogr, 2002 Jan 05; (30). PMID: 11773300
Highly Cited.
Underutilization of breast-conserving therapy in a predominantly rural population: need for improved surgeon and public education.
P Hokanson, R Seshadri, K D Miller.
Clin Breast Cancer, 2002 Mar 20; 1(1). PMID: 11899394
Obesity in adulthood and its consequences for life expectancy: a life-table analysis.
Anna Peeters, Jan J Barendregt, +4 authors, NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group.
Ann Intern Med, 2003 Jan 07; 138(1). PMID: 12513041
Highly Cited.
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer.
Ann H Partridge, Philip S Wang, Eric P Winer, Jerry Avorn.
J Clin Oncol, 2003 Feb 15; 21(4). PMID: 12586795
Highly Cited.
The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27.
Harry D Bear, Stewart Anderson, +9 authors, National Surgical Adjuvant Breast and Bowel Project Protocol B-27.
J Clin Oncol, 2003 Oct 16; 21(22). PMID: 14559892
Highly Cited.
Audit of compliance to adjuvant chemotherapy and radiotherapy guidelines in breast cancer in a cancer network.
S P Balasubramanian, S Murrow, +2 authors, M W Reed.
Breast, 2003 Dec 09; 12(2). PMID: 14659343
Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18.
B Fisher, A Brown, +11 authors, N V Dimitrov.
J Clin Oncol, 1997 Jul 01; 15(7). PMID: 9215816
Highly Cited.
Primary chemotherapy in operable breast cancer: eight-year experience at the Milan Cancer Institute.
G Bonadonna, P Valagussa, +4 authors, M Zambetti.
J Clin Oncol, 1998 Jan 24; 16(1). PMID: 9440728
Highly Cited.
Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer.
Aman U Buzdar, Nuhad K Ibrahim, +17 authors, Gabriel N Hortobagyi.
J Clin Oncol, 2005 Mar 02; 23(16). PMID: 15738535
Highly Cited.
Undertreatment of obese women receiving breast cancer chemotherapy.
Jennifer J Griggs, Melony E S Sorbero, Gary H Lyman.
Arch Intern Med, 2005 Jun 16; 165(11). PMID: 15956006
Obesity.
David W Haslam, W Philip T James.
Lancet, 2005 Oct 04; 366(9492). PMID: 16198769
Highly Cited. Review.
Treatment of local breast carcinoma in Florida: the role of the distance to radiation therapy facilities.
Lydia Voti, Lisa C Richardson, +3 authors, Jan Willem W Coebergh.
Cancer, 2005 Nov 29; 106(1). PMID: 16311987
The use of radiation as a component of breast conservation therapy in National Comprehensive Cancer Network Centers.
Thomas A Buchholz, Richard L Theriault, +5 authors, Jane C Weeks.
J Clin Oncol, 2006 Jan 20; 24(3). PMID: 16421417
Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27.
Harry D Bear, Stewart Anderson, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 Apr 12; 24(13). PMID: 16606972
Highly Cited.
Neoadjuvant chemotherapy in invasive lobular carcinoma may not improve rates of breast conservation.
Judy C Boughey, Jamie Wagner, +7 authors, Isabelle Bedrosian.
Ann Surg Oncol, 2009 Mar 13; 16(6). PMID: 19280264    Free PMC article.
Medication adherence in HIV-infected smokers: the mediating role of depressive symptoms.
Monica S Webb, Peter A Vanable, Michael P Carey, Donald C Blair.
AIDS Educ Prev, 2009 Jun 27; 21(3 Suppl). PMID: 19537957
Long-term medication adherence after myocardial infarction: experience of a community.
Nilay D Shah, Shannon M Dunlay, +4 authors, Véronique L Roger.
Am J Med, 2009 Jun 30; 122(10). PMID: 19560749    Free PMC article.
The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial.
Evandro de Azambuja, Worta McCaskill-Stevens, +17 authors, Martine Piccart-Gebhart.
Breast Cancer Res Treat, 2009 Sep 05; 119(1). PMID: 19731015
Effect of distance to radiation treatment facility on use of radiation therapy after mastectomy in elderly women.
Rinaa S Punglia, Jane C Weeks, Bridget A Neville, Craig C Earle.
Int J Radiat Oncol Biol Phys, 2006 Jul 04; 66(1). PMID: 16814955
Tobacco assessment in actively accruing National Cancer Institute Cooperative Group Program Clinical Trials.
Erica N Peters, Essie Torres, +6 authors, Graham W Warren.
J Clin Oncol, 2012 Jun 13; 30(23). PMID: 22689794    Free PMC article.
A Phase II trial of docetaxel and carboplatin administered every 2 weeks as preoperative therapy for stage II or III breast cancer: NCCTG study N0338.
Vivek Roy, Barbara A Pockaj, +5 authors, Edith A Perez.
Am J Clin Oncol, 2012 Aug 08; 36(6). PMID: 22868240    Free PMC article.
Accuracy of self-reported tobacco use in newly diagnosed cancer patients.
Nelson A Morales, Michelle A Romano, +4 authors, Graham W Warren.
Cancer Causes Control, 2013 Apr 05; 24(6). PMID: 23553611    Free PMC article.
Nicotine and lung cancer.
Graham W Warren, Anurag K Singh.
J Carcinog, 2013 Apr 20; 12. PMID: 23599683    Free PMC article.
Current smoking is associated with a larger waist circumference and a more androgenic profile in young healthy women from high-risk breast cancer families.
Carolina Ellberg, Håkan Olsson, Helena Jernström.
Cancer Causes Control, 2018 Jan 05; 29(2). PMID: 29299723    Free PMC article.