Journal Article
. 2011 May; 1:240-50.
doi: 10.7150/thno/v01p0240.

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Peng Huang 1 Cheng Xu  Jing Lin  Can Wang  Xiansong Wang  Chunlei Zhang  Xuejiao Zhou  Shouwu Guo  Daxiang Cui  
Affiliations
  • PMID: 21562631
  •     24 References
  •     110 citations

Abstract

Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and π-π stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.

Keywords: Chlorin e6; Drug delivery.; Folic acid; Graphene oxide; Photodynamic therapy.

Photosensitizer-loaded dendrimer-modified multi-walled carbon nanotubes for photodynamic therapy.
Peng Huang, Jing Lin, +3 authors, Daxiang Cui.
J Control Release, 2011 Dec 27; 152 Suppl 1. PMID: 22195908
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
Jonathan P Celli, Bryan Q Spring, +5 authors, Tayyaba Hasan.
Chem Rev, 2010 Apr 01; 110(5). PMID: 20353192    Free PMC article.
Highly Cited. Review.
Regulation of singlet oxygen generation using single-walled carbon nanotubes.
Zhi Zhu, Zhiwen Tang, +3 authors, Weihong Tan.
J Am Chem Soc, 2008 Jul 30; 130(33). PMID: 18661988
Carbon nanohorns as anticancer drug carriers.
Kumiko Ajima, Masako Yudasaka, +3 authors, Sumio Iijima.
Mol Pharm, 2005 Dec 06; 2(6). PMID: 16323954
Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity.
V Guillemard, H U Saragovi.
Cancer Res, 2001 Feb 24; 61(2). PMID: 11212270
Photodynamic therapy with fullerenes.
Pawel Mroz, George P Tegos, +3 authors, Michael R Hamblin.
Photochem Photobiol Sci, 2007 Nov 02; 6(11). PMID: 17973044    Free PMC article.
Review.
Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors.
B Johnsson, S Löfås, G Lindquist.
Anal Biochem, 1991 Nov 01; 198(2). PMID: 1724720
Highly Cited.
Activatable photosensitizers for imaging and therapy.
Jonathan F Lovell, Tracy W B Liu, Juan Chen, Gang Zheng.
Chem Rev, 2010 Jan 29; 110(5). PMID: 20104890
Highly Cited. Review.
Nano-Graphene Oxide for Cellular Imaging and Drug Delivery.
Xiaoming Sun, Zhuang Liu, +4 authors, Hongjie Dai.
Nano Res, 2008 Jan 01; 1(3). PMID: 20216934    Free PMC article.
Highly Cited.
Photodynamic therapy.
T J Dougherty, C J Gomer, +5 authors, Q Peng.
J Natl Cancer Inst, 1998 Jun 24; 90(12). PMID: 9637138    Free PMC article.
Highly Cited. Review.
Nanoparticles as vehicles for delivery of photodynamic therapy agents.
Denise Bechet, Pierre Couleaud, +3 authors, Muriel Barberi-Heyob.
Trends Biotechnol, 2008 Sep 23; 26(11). PMID: 18804298
Highly Cited. Review.
Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs.
Liming Zhang, Jingguang Xia, +2 authors, Zhijun Zhang.
Small, 2009 Dec 25; 6(4). PMID: 20033930
Highly Cited.
Selective antitumor effect of novel protease-mediated photodynamic agent.
Yongdoo Choi, Ralph Weissleder, Ching-Hsuan Tung.
Cancer Res, 2006 Jul 20; 66(14). PMID: 16849570
Reduction of graphene oxide via L-ascorbic acid.
Jiali Zhang, Haijun Yang, +3 authors, Shouwu Guo.
Chem Commun (Camb), 2010 Feb 04; 46(7). PMID: 20126730
PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
Zhuang Liu, Joshua T Robinson, Xiaoming Sun, Hongjie Dai.
J Am Chem Soc, 2008 Jul 30; 130(33). PMID: 18661992    Free PMC article.
Highly Cited.
Chemical methods for the production of graphenes.
Sungjin Park, Rodney S Ruoff.
Nat Nanotechnol, 2009 Apr 08; 4(4). PMID: 19350030
Highly Cited. Review.
Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy.
Kai Yang, Shuai Zhang, +3 authors, Zhuang Liu.
Nano Lett, 2010 Aug 06; 10(9). PMID: 20684528
Highly Cited.
Photodynamic therapy for treatment of solid tumors--potential and technical challenges.
Zheng Huang, Heping Xu, +5 authors, Yang K Chen.
Technol Cancer Res Treat, 2008 Jul 23; 7(4). PMID: 18642969    Free PMC article.
Review.
Preparation of graphene relying on porphyrin exfoliation of graphite.
Jianxin Geng, Byung-Seon Kong, Seung Bo Yang, Hee-Tae Jung.
Chem Commun (Camb), 2010 Jun 16; 46(28). PMID: 20549007
Graphene-based materials in electrochemistry.
Da Chen, Longhua Tang, Jinghong Li.
Chem Soc Rev, 2010 Jul 01; 39(8). PMID: 20589275
Review.
Photodynamic therapy: a review.
J S McCaughan.
Drugs Aging, 1999 Aug 25; 15(1). PMID: 10459732
Review.
Magnetic chitosan nanoparticles as a drug delivery system for targeting photodynamic therapy.
Yun Sun, Zhi-Long Chen, +3 authors, Xiao-Xia Du.
Nanotechnology, 2009 May 08; 20(13). PMID: 19420486
Fabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapy.
Minfang Zhang, Tatsuya Murakami, +5 authors, Masako Yudasaka.
Proc Natl Acad Sci U S A, 2008 Sep 26; 105(39). PMID: 18815374    Free PMC article.
Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy.
Peng Huang, Zhiming Li, +9 authors, Daxiang Cui.
Biomaterials, 2011 Feb 10; 32(13). PMID: 21303717
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.
Qimeng Quan, Jin Xie, +9 authors, Xiaoyuan Chen.
Mol Pharm, 2011 Aug 16; 8(5). PMID: 21838321    Free PMC article.
Biological interactions of graphene-family nanomaterials: an interdisciplinary review.
Vanesa C Sanchez, Ashish Jachak, Robert H Hurt, Agnes B Kane.
Chem Res Toxicol, 2011 Oct 01; 25(1). PMID: 21954945    Free PMC article.
Highly Cited. Review.
Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging.
Zibo Li, Qiaoling Jin, +7 authors, Peter S Conti.
Theranostics, 2012 Jan 03; 1. PMID: 22211143    Free PMC article.
Biomedical applications of graphene.
He Shen, Liming Zhang, Min Liu, Zhijun Zhang.
Theranostics, 2012 Mar 27; 2(3). PMID: 22448195    Free PMC article.
Highly Cited.
Multiwalled carbon nanotubes interact with macrophages and influence tumor progression and metastasis.
Man Yang, Jie Meng, +5 authors, Haiyan Xu.
Theranostics, 2012 Apr 18; 2(3). PMID: 22509194    Free PMC article.
Pharmacokinetics, metabolism and toxicity of carbon nanotubes for biomedical purposes.
Sheng-Tao Yang, Jianbin Luo, Qinghan Zhou, Haifang Wang.
Theranostics, 2012 Apr 18; 2(3). PMID: 22509195    Free PMC article.
The biocompatibility of nanodiamonds and their application in drug delivery systems.
Ying Zhu, Jing Li, +7 authors, Qing Huang.
Theranostics, 2012 Apr 18; 2(3). PMID: 22509196    Free PMC article.
Graphene: a versatile nanoplatform for biomedical applications.
Yin Zhang, Tapas R Nayak, Hao Hong, Weibo Cai.
Nanoscale, 2012 Jun 02; 4(13). PMID: 22653227    Free PMC article.
Review.
Fluorescent magnetic nanoparticle-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of in vivo gastric cancer.
Jing Ruan, Jiajia Ji, +4 authors, Daxiang Cui.
Nanoscale Res Lett, 2012 Jun 20; 7(1). PMID: 22709686    Free PMC article.
Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy.
Peng Huang, Jing Lin, +9 authors, Xiaoyuan Chen.
Adv Mater, 2012 Jun 22; 24(37). PMID: 22718562    Free PMC article.
Highly Cited.
Bioconjugated pluronic triblock-copolymer micelle-encapsulated quantum dots for targeted imaging of cancer: in vitro and in vivo studies.
Liwei Liu, Ken-Tye Yong, +7 authors, Paras N Prasad.
Theranostics, 2012 Aug 17; 2(7). PMID: 22896772    Free PMC article.
Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging.
Yuling Xiao, Hao Hong, +9 authors, Shaoqin Gong.
Theranostics, 2012 Aug 24; 2(8). PMID: 22916075    Free PMC article.
Shining light on nanotechnology to help repair and regeneration.
Asheesh Gupta, Pinar Avci, +7 authors, Michael R Hamblin.
Biotechnol Adv, 2012 Sep 07; 31(5). PMID: 22951919    Free PMC article.
Review.
Cell specific cytotoxicity and uptake of graphene nanoribbons.
Sayan Mullick Chowdhury, Gaurav Lalwani, +3 authors, Balaji Sitharaman.
Biomaterials, 2012 Oct 18; 34(1). PMID: 23072942    Free PMC article.
Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.
Shouju Wang, Peng Huang, +8 authors, Xiaoyuan Chen.
Adv Mater, 2013 Feb 14; 25(22). PMID: 23404693    Free PMC article.
Phase and size controllable synthesis of NaYbF4 nanocrystals in oleic acid/ionic liquid two-phase system for targeted fluorescent imaging of gastric cancer.
Liyuan Pan, Meng He, +5 authors, Daxiang Cui.
Theranostics, 2013 Mar 09; 3(3). PMID: 23471455    Free PMC article.
Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy.
Peng Huang, Jing Lin, +9 authors, Xiaoyuan Chen.
Biomaterials, 2013 Mar 26; 34(19). PMID: 23523428    Free PMC article.
Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging.
Jing Lin, Zhijun Zhou, +6 authors, Daxiang Cui.
Nanoscale Res Lett, 2013 Apr 17; 8(1). PMID: 23587362    Free PMC article.
Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.
Jing Lin, Shouju Wang, +9 authors, Zhihong Nie.
ACS Nano, 2013 Jun 01; 7(6). PMID: 23721576    Free PMC article.
Highly Cited.
VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.
Zhongchan Sun, Peng Huang, +8 authors, Xiaoyuan Chen.
Nanoscale, 2013 Jun 19; 5(15). PMID: 23770832    Free PMC article.
Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production.
Ji Young Park, Hyun Dong Ji, +10 authors, Man Hee Rhee.
Evid Based Complement Alternat Med, 2013 Sep 03; 2013. PMID: 23997795    Free PMC article.
In vitro hematological and in vivo vasoactivity assessment of dextran functionalized graphene.
Sayan Mullick Chowdhury, Shruti Kanakia, +5 authors, Balaji Sitharaman.
Sci Rep, 2013 Sep 05; 3. PMID: 24002570    Free PMC article.
Enhancing cell nucleus accumulation and DNA cleavage activity of anti-cancer drug via graphene quantum dots.
Chong Wang, Congyu Wu, +5 authors, Shouwu Guo.
Sci Rep, 2013 Oct 05; 3. PMID: 24092333    Free PMC article.
Preparation and functionalization of graphene nanocomposites for biomedical applications.
Kai Yang, Liangzhu Feng, +2 authors, Zhuang Liu.
Nat Protoc, 2013 Nov 10; 8(12). PMID: 24202553    Free PMC article.
Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.
Peng Huang, Jing Lin, +10 authors, Xiaoyuan Chen.
Angew Chem Int Ed Engl, 2013 Dec 10; 52(52). PMID: 24318645    Free PMC article.
Highly Cited.
Identification of volatile biomarkers of gastric cancer cells and ultrasensitive electrochemical detection based on sensing interface of Au-Ag alloy coated MWCNTs.
Yixia Zhang, Guo Gao, +9 authors, Daxiang Cui.
Theranostics, 2014 Jan 28; 4(2). PMID: 24465273    Free PMC article.
Graphene-based contrast agents for photoacoustic and thermoacoustic tomography.
Gaurav Lalwani, Xin Cai, +2 authors, Balaji Sitharaman.
Photoacoustics, 2014 Feb 04; 1(3-4). PMID: 24490141    Free PMC article.
Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.
Pengfei Rong, Kai Yang, +10 authors, Xiaoyuan Chen.
Theranostics, 2014 Feb 08; 4(3). PMID: 24505232    Free PMC article.
Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug.
Hao Wang, Wei Gu, +2 authors, Qunyuan Xu.
Int J Nanomedicine, 2014 Mar 29; 9. PMID: 24672236    Free PMC article.
BRCAA1 antibody- and Her2 antibody-conjugated amphiphilic polymer engineered CdSe/ZnS quantum dots for targeted imaging of gastric cancer.
Chao Li, Yang Ji, +7 authors, Daxiang Cui.
Nanoscale Res Lett, 2014 Jun 19; 9(1). PMID: 24940175    Free PMC article.
RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer.
Can Wang, Chenchen Bao, +5 authors, Daxiang Cui.
Nanoscale Res Lett, 2014 Jun 21; 9(1). PMID: 24948888    Free PMC article.
HAI-178 antibody-conjugated fluorescent magnetic nanoparticles for targeted imaging and simultaneous therapy of gastric cancer.
Can Wang, Chenchen Bao, +9 authors, Daxiang Cui.
Nanoscale Res Lett, 2014 Jun 21; 9(1). PMID: 24948895    Free PMC article.
Biological interactions and safety of graphene materials.
Ashish C Jachak, Megan Creighton, +2 authors, Robert H Hurt.
MRS Bull, 2012 Dec 01; 37(12). PMID: 25018584    Free PMC article.
Surface engineering of graphene-based nanomaterials for biomedical applications.
Sixiang Shi, Feng Chen, Emily B Ehlerding, Weibo Cai.
Bioconjug Chem, 2014 Aug 15; 25(9). PMID: 25117569    Free PMC article.
Review.
Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy.
Peng Huang, Pengfei Rong, +12 authors, Xiaoyuan Chen.
Adv Mater, 2014 Aug 16; 26(37). PMID: 25123089    Free PMC article.
Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma.
Victoria Monge-Fuentes, Luis Alexandre Muehlmann, Ricardo Bentes de Azevedo.
Nano Rev, 2014 Oct 16; 5. PMID: 25317253    Free PMC article.
Review.
VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.
Sixiang Shi, Kai Yang, +6 authors, Weibo Cai.
Biomaterials, 2014 Dec 06; 39. PMID: 25477170    Free PMC article.
Reducing X-Ray Induced Oxidative Damages in Fibroblasts with Graphene Oxide.
Yong Qiao, Peipei Zhang, +2 authors, Ming Su.
Nanomaterials (Basel), 2014 Dec 23; 4(2). PMID: 25530873    Free PMC article.
Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide.
Xuefeng Yan, Gang Niu, +10 authors, Xiaoyuan Chen.
Biomaterials, 2014 Dec 30; 42. PMID: 25542797    Free PMC article.
Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies.
Xuefeng Yan, Hao Hu, +6 authors, Xiaoyuan Chen.
Nanoscale, 2015 Jan 13; 7(6). PMID: 25573051    Free PMC article.
An aptamer-targeting photoresponsive drug delivery system using "off-on" graphene oxide wrapped mesoporous silica nanoparticles.
Yuxia Tang, Hao Hu, +7 authors, Xiaoyuan Chen.
Nanoscale, 2015 Mar 19; 7(14). PMID: 25782595    Free PMC article.
Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy.
Olena Taratula, Mehulkumar Patel, +4 authors, Oleh Taratula.
Int J Nanomedicine, 2015 Apr 08; 10. PMID: 25848255    Free PMC article.
Graphene-based nanovehicles for photodynamic medical therapy.
Yan Li, Haiqing Dong, Yongyong Li, Donglu Shi.
Int J Nanomedicine, 2015 Apr 08; 10. PMID: 25848263    Free PMC article.
Review.
Graphene as cancer theranostic tool: progress and future challenges.
Marco Orecchioni, Roberto Cabizza, Alberto Bianco, Lucia Gemma Delogu.
Theranostics, 2015 Apr 22; 5(7). PMID: 25897336    Free PMC article.
Review.
Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA.
Daxiang Cui, Chunlei Zhang, +13 authors, Peixuan Guo.
Sci Rep, 2015 Jul 04; 5. PMID: 26137913    Free PMC article.
CD44v6 Monoclonal Antibody-Conjugated Gold Nanostars for Targeted Photoacoustic Imaging and Plasmonic Photothermal Therapy of Gastric Cancer Stem-like Cells.
Shujing Liang, Chao Li, +7 authors, Daxiang Cui.
Theranostics, 2015 Jul 15; 5(9). PMID: 26155313    Free PMC article.
Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy.
Peng Huang, Shouju Wang, +7 authors, Xiaoyuan Chen.
J Biomed Nanotechnol, 2015 Aug 25; 11(1). PMID: 26301305    Free PMC article.
Inhibitory effect of caffeic acid on ADP-induced thrombus formation and platelet activation involves mitogen-activated protein kinases.
Yu Lu, Quan Li, +4 authors, Jing-Yan Han.
Sci Rep, 2015 Sep 09; 5. PMID: 26345207    Free PMC article.
Can nanotechnology potentiate photodynamic therapy?
Ying-Ying Huang, Sulbha K Sharma, +6 authors, Michael R Hamblin.
Nanotechnol Rev, 2012 Mar 01; 1(2). PMID: 26361572    Free PMC article.
Drug Carrier for Photodynamic Cancer Therapy.
Tilahun Ayane Debele, Sydney Peng, Hsieh-Chih Tsai.
Int J Mol Sci, 2015 Sep 22; 16(9). PMID: 26389879    Free PMC article.
Review.
Graphene-based platforms for cancer therapeutics.
Sunny C Patel, Stephen Lee, +3 authors, Balaji Sitharaman.
Ther Deliv, 2016 Jan 16; 7(2). PMID: 26769305    Free PMC article.
Review.
Association of rituximab with graphene oxide confers direct cytotoxicity for CD20-positive lymphoma cells.
Chengke Luo, Zhenghao Deng, +9 authors, Xinjian Chen.
Oncotarget, 2016 Feb 10; 7(11). PMID: 26859679    Free PMC article.
Toxicology of graphene-based nanomaterials.
Gaurav Lalwani, Michael D'Agati, Amit Mahmud Khan, Balaji Sitharaman.
Adv Drug Deliv Rev, 2016 May 08; 105(Pt B). PMID: 27154267    Free PMC article.
Review.
Graphene-based nanomaterials for bioimaging.
Jing Lin, Xiaoyuan Chen, Peng Huang.
Adv Drug Deliv Rev, 2016 May 29; 105(Pt B). PMID: 27233213    Free PMC article.
Review.
Human CIK Cells Loaded with Au Nanorods as a Theranostic Platform for Targeted Photoacoustic Imaging and Enhanced Immunotherapy and Photothermal Therapy.
Yao Yang, Jingjing Zhang, +10 authors, Daxiang Cui.
Nanoscale Res Lett, 2016 Jun 09; 11(1). PMID: 27271853    Free PMC article.
Polymeric Nanoparticles of Brazilian Red Propolis Extract: Preparation, Characterization, Antioxidant and Leishmanicidal Activity.
Ticiano Gomes do Nascimento, Priscilla Fonseca da Silva, +10 authors, David G Watson.
Nanoscale Res Lett, 2016 Jun 19; 11(1). PMID: 27316742    Free PMC article.
Carbon Nanomaterials Interfacing with Neurons: An In vivo Perspective.
Michele Baldrighi, Massimo Trusel, Raffaella Tonini, Silvia Giordani.
Front Neurosci, 2016 Jul 05; 10. PMID: 27375413    Free PMC article.
Review.
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy.
Zijian Zhou, Jibin Song, Liming Nie, Xiaoyuan Chen.
Chem Soc Rev, 2016 Oct 11; 45(23). PMID: 27722328    Free PMC article.
Highly Cited. Review.
ICG-conjugated Magnetic Graphene Oxide for Dual Photothermal and Photodynamic Therapy.
Ismail Ocsoy, Nuran Isiklan, +2 authors, Weihong Tan.
RSC Adv, 2016 Oct 25; 6(36). PMID: 27774142    Free PMC article.
Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy.
Dena Dorniani, Bullo Saifullah, +4 authors, Lance J Twyman.
Nanoscale Res Lett, 2016 Nov 09; 11(1). PMID: 27822913    Free PMC article.
Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications.
Sheng Wang, Jing Lin, +2 authors, Peng Huang.
Theranostics, 2016 Nov 24; 6(13). PMID: 27877243    Free PMC article.
Review.
Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy.
Feng Fan, Yue Yu, +7 authors, Xianzhu Yang.
Theranostics, 2017 Apr 25; 7(5). PMID: 28435466    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptide-photosensitizer conjugate.
Gayong Shim, Mi-Gyeong Kim, +2 authors, Yu-Kyoung Oh.
Acta Pharmacol Sin, 2017 May 30; 38(6). PMID: 28552914    Free PMC article.
Improved Electrochemical Detection of Zinc Ions Using Electrode Modified with Electrochemically Reduced Graphene Oxide.
Jiri Kudr, Lukas Richtera, +7 authors, Rene Kizek.
Materials (Basel), 2016 Jan 07; 9(1). PMID: 28787832    Free PMC article.
Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production.
Nahid Mehraban, Harold S Freeman.
Materials (Basel), 2015 Jul 20; 8(7). PMID: 28793448    Free PMC article.
Review.
Advanced Functional Nanomaterials for Theranostics.
Haoyuan Huang, Jonathan F Lovell.
Adv Funct Mater, 2017 Aug 22; 27(2). PMID: 28824357    Free PMC article.
Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy.
Zeyong Li, Yuee Cai, +3 authors, Meiwan Chen.
Int J Nanomedicine, 2017 Sep 19; 12. PMID: 28919756    Free PMC article.
Role of Nanodiamonds in Drug Delivery and Stem Cell Therapy.
Shakeel Ahmed Ansari, Rukhsana Satar, +3 authors, Syed Kashif Zaidi.
Iran J Biotechnol, 2017 Sep 30; 14(3). PMID: 28959329    Free PMC article.
Review.
Targeted Nanomaterials for Phototherapy.
Upendra Chitgupi, Yiru Qin, Jonathan F Lovell.
Nanotheranostics, 2017 Oct 27; 1(1). PMID: 29071178    Free PMC article.
Review.
The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy.
Zahraa Youssef, Régis Vanderesse, +8 authors, Amirah Mohd Gazzali.
Cancer Nanotechnol, 2017 Nov 07; 8(1). PMID: 29104699    Free PMC article.
Review.
Intratumoral Delivery of Doxorubicin on Folate-Conjugated Graphene Oxide by In-Situ Forming Thermo-Sensitive Hydrogel for Breast Cancer Therapy.
Yi Teng Fong, Chih-Hao Chen, Jyh-Ping Chen.
Nanomaterials (Basel), 2017 Nov 15; 7(11). PMID: 29135959    Free PMC article.
In vivo wireless photonic photodynamic therapy.
Akshaya Bansal, Fengyuan Yang, +2 authors, John S Ho.
Proc Natl Acad Sci U S A, 2018 Jan 31; 115(7). PMID: 29378941    Free PMC article.
Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides.
Seung Won Jun, Junyoung Kwon, +5 authors, Chang-Seok Kim.
Biomed Opt Express, 2018 Mar 20; 9(2). PMID: 29552406    Free PMC article.
Simultaneous Monitoring of Cell-surface Receptor and Tumor-targeted Photodynamic Therapy via TdT-initiated Poly-G-Quadruplexes.
Tianhui Shi, Menglin Wang, +6 authors, Shouzhuo Yao.
Sci Rep, 2018 Apr 05; 8(1). PMID: 29615769    Free PMC article.
Graphene Oxide/ZnS:Mn Nanocomposite Functionalized with Folic Acid as a Nontoxic and Effective Theranostic Platform for Breast Cancer Treatment.
Daysi Diaz-Diestra, Bibek Thapa, +3 authors, Brad R Weiner.
Nanomaterials (Basel), 2018 Jul 04; 8(7). PMID: 29966355    Free PMC article.
Combined Adsorption and Covalent Linking of Paclitaxel on Functionalized Nano-Graphene Oxide for Inhibiting Cancer Cells.
Wei Zhuang, Linjiao He, +7 authors, Hanjie Ying.
ACS Omega, 2018 Sep 18; 3(2). PMID: 30221218    Free PMC article.
Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors.
Yan Yan, Ruizhi Wang, +4 authors, Shimeng Yin.
Drug Deliv, 2018 Oct 24; 25(1). PMID: 30348025    Free PMC article.
Photothermal exposure of polydopamine-coated branched Au-Ag nanoparticles induces cell cycle arrest, apoptosis, and autophagy in human bladder cancer cells.
Xiaoming Zhao, Tianyang Qi, +6 authors, Jinlan Jiang.
Int J Nanomedicine, 2018 Nov 10; 13. PMID: 30410328    Free PMC article.
Redox-responsive hyaluronic acid-functionalized graphene oxide nanosheets for targeted delivery of water-insoluble cancer drugs.
Jian Liu, Doudou Zhang, +4 authors, Lee Jia.
Int J Nanomedicine, 2018 Dec 12; 13. PMID: 30532533    Free PMC article.
Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors.
Mingying Yang, Tao Yang, Chuanbin Mao.
Angew Chem Int Ed Engl, 2019 Jan 22; 58(40). PMID: 30663185    Free PMC article.
Review.
Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics.
Arianna Gazzi, Laura Fusco, +5 authors, Lucia Gemma Delogu.
Front Bioeng Biotechnol, 2019 Nov 12; 7. PMID: 31709252    Free PMC article.
Review.
The Dark Side: Photosensitizer Prodrugs.
Sara Sansaloni-Pastor, Jordan Bouilloux, Norbert Lange.
Pharmaceuticals (Basel), 2019 Oct 09; 12(4). PMID: 31590223    Free PMC article.
Review.
Controlling the transverse proton relaxivity of magnetic graphene oxide.
Bibek Thapa, Daysi Diaz-Diestra, +7 authors, Gerardo Morell.
Sci Rep, 2019 Apr 06; 9(1). PMID: 30948768    Free PMC article.
rGO nanomaterial-mediated cancer targeting and photothermal therapy in a microfluidic co-culture platform.
Seok Gyu Mun, Hyung Woo Choi, +6 authors, Bong Geun Chung.
Nano Converg, 2020 Mar 18; 7(1). PMID: 32180051    Free PMC article.
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment.
D Gao, X Guo, +7 authors, Z Yang.
Mater Today Bio, 2020 Mar 27; 5. PMID: 32211603    Free PMC article.
Review.
N-acetyl cysteine-loaded graphene oxide-collagen hybrid membrane for scarless wound healing.
Jialun Li, Chuchao Zhou, +12 authors, Zhenxing Wang.
Theranostics, 2019 Sep 20; 9(20). PMID: 31534523    Free PMC article.
A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans.
Selene Acosta, Carlos Moreno-Aguilar, +5 authors, Mildred Quintana.
Beilstein J Nanotechnol, 2020 Aug 01; 11. PMID: 32733780    Free PMC article.
Toxicity of Carbon Nanomaterials and Their Potential Application as Drug Delivery Systems: In Vitro Studies in Caco-2 and MCF-7 Cell Lines.
Rosa Garriga, Tania Herrero-Continente, +4 authors, María Jesús Rodríguez-Yoldi.
Nanomaterials (Basel), 2020 Aug 23; 10(8). PMID: 32824730    Free PMC article.
The application of graphene-based biomaterials in biomedicine.
Shanying Han, Jie Sun, +2 authors, Renjie Chai.
Am J Transl Res, 2019 Jul 18; 11(6). PMID: 31312342    Free PMC article.
Review.
New Polylactic Acid Multifunctional Ultrasound Contrast Agent Based on Graphene Oxide as the Carrier of Targeted Factor and Drug Delivery.
Jie Zhang, Limei Song, +5 authors, Ying Wang.
ACS Omega, 2019 Aug 29; 4(3). PMID: 31459655    Free PMC article.
The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review.
Hamidur Rahman, Md Rakib Hossain, Tahmina Ferdous.
J Mol Liq, 2020 Oct 06; 320. PMID: 33012931    Free PMC article.
Review.
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment.
Piotr Gierlich, Ana I Mata, +3 authors, Lígia C Gomes-da-Silva.
Molecules, 2020 Nov 19; 25(22). PMID: 33202648    Free PMC article.
Review.
Carbon-Based Materials for Photo-Triggered Theranostic Applications.
Karunya Albert, Hsin-Yun Hsu.
Molecules, 2016 Nov 24; 21(11). PMID: 27879628    Free PMC article.
Review.
Gadolinium (III) oxide nanoparticles coated with folic acid-functionalized poly(β-cyclodextrin-co-pentetic acid) as a biocompatible targeted nano-contrast agent for cancer diagnostic: in vitro and in vivo studies.
Tohid Mortezazadeh, Elham Gholibegloo, +4 authors, Mehdi Khoobi.
MAGMA, 2019 Feb 08; 32(4). PMID: 30730021
Nanocomposites as biomolecules delivery agents in nanomedicine.
Magdalena Bamburowicz-Klimkowska, Magdalena Poplawska, Ireneusz P Grudzinski.
J Nanobiotechnology, 2019 Apr 05; 17(1). PMID: 30943985    Free PMC article.
Review.
Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy.
Lucas D Dias, Ivan S Mfouo-Tynga.
Biomimetics (Basel), 2020 Oct 18; 5(4). PMID: 33066431    Free PMC article.
Review.
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing.
Song Zhang, Jiangtao Shen, Dali Li, Yiyun Cheng.
Theranostics, 2021 Jan 05; 11(2). PMID: 33391496    Free PMC article.
Review.
Graphene Oxide Nanoparticle-Loaded Ginsenoside Rg3 Improves Photodynamic Therapy in Inhibiting Malignant Progression and Stemness of Osteosarcoma.
Shou-Liang Lu, Yan-Hua Wang, +4 authors, Cai Cheng.
Front Mol Biosci, 2021 May 11; 8. PMID: 33968991    Free PMC article.
Graphene Oxide Topical Administration: Skin Permeability Studies.
Filipa A L S Silva, Raquel Costa-Almeida, +7 authors, Artur M Pinto.
Materials (Basel), 2021 Jun 03; 14(11). PMID: 34070414    Free PMC article.
Comprehensive Application of Graphene: Emphasis on Biomedical Concerns.
S Syama, P V Mohanan.
Nanomicro Lett, 2019 Jan 12; 11(1). PMID: 34137957    Free PMC article.
Review.
Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers.
Xinning Wang, Dong Luo, James P Basilion.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34203805    Free PMC article.
Review.
Fluorescence Spectroscopy of Porphyrins and Phthalocyanines: Some Insights into Supramolecular Self-Assembly, Microencapsulation, and Imaging Microscopy.
Raquel Teixeira, Vanda Vaz Serra, +3 authors, Sílvia M B Costa.
Molecules, 2021 Jul 25; 26(14). PMID: 34299539    Free PMC article.
Review.
Evaluation of the Biological Activity of Folic Acid-Modified Paclitaxel-Loaded Gold Nanoparticles.
Bin Ren, Zhong-Chao Cai, +2 authors, Mei-Xia Zhao.
Int J Nanomedicine, 2021 Oct 28; 16. PMID: 34703225    Free PMC article.
Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction.
Karina J Lagos, Hilde H Buzzá, Vanderlei S Bagnato, María Paulina Romero.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008458    Free PMC article.
Review.
Graphene oxide-ellagic acid nanocomposite as effective anticancer and antimicrobial agent.
Samer Hasan Hussein-Al-Ali, Suha Mujahed Abudoleh, +2 authors, Arul Palanisamy.
IET Nanobiotechnol, 2021 Oct 26; 15(1). PMID: 34694731    Free PMC article.
Graphene-Based Nanomaterials for Biomedical Imaging.
So Yun Lee, Mina Kwon, +3 authors, Ki Su Kim.
Adv Exp Med Biol, 2022 Feb 18; 1351. PMID: 35175615
Reactive Oxygen Species and Folate Receptor-Targeted Nanophotosensitizers Composed of Folic Acid-Conjugated and Poly(ethylene glycol)-Chlorin e6 Tetramer Having Diselenide Linkages for Targeted Photodynamic Treatment of Cancer Cells.
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328538    Free PMC article.
Microencapsulated Multifunctionalized Graphene Oxide Equipped with Chloroquine for Efficient and Sustained siRNA Delivery.
Rana Imani, Satya Prakash, +2 authors, Shahab Faghihi.
Biomed Res Int, 2022 Apr 27; 2022. PMID: 35469347    Free PMC article.
Magnetic chitosan/graphene oxide composite loaded with novel photosensitizer for enhanced photodynamic therapy.
Xiang Qin, Hongyue Zhang, Zhiqiang Wang, Yingxue Jin.
RSC Adv, 2018 Mar 14; 8(19). PMID: 35540483    Free PMC article.