Journal Article
. 2011 May; 1:240-50.
doi: 10.7150/thno/v01p0240.

Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy

Peng Huang 1 Cheng Xu  Jing Lin  Can Wang  Xiansong Wang  Chunlei Zhang  Xuejiao Zhou  Shouwu Guo  Daxiang Cui  
  • PMID: 21562631
  •     24 References
  •     110 citations


Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and π-π stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.

Keywords: Chlorin e6; Drug delivery.; Folic acid; Graphene oxide; Photodynamic therapy.

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Theranostics, 2019 Sep 20; 9(20). PMID: 31534523    Free PMC article.
A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans.
Selene Acosta, Carlos Moreno-Aguilar, +5 authors, Mildred Quintana.
Beilstein J Nanotechnol, 2020 Aug 01; 11. PMID: 32733780    Free PMC article.
Toxicity of Carbon Nanomaterials and Their Potential Application as Drug Delivery Systems: In Vitro Studies in Caco-2 and MCF-7 Cell Lines.
Rosa Garriga, Tania Herrero-Continente, +4 authors, María Jesús Rodríguez-Yoldi.
Nanomaterials (Basel), 2020 Aug 23; 10(8). PMID: 32824730    Free PMC article.
The application of graphene-based biomaterials in biomedicine.
Shanying Han, Jie Sun, +2 authors, Renjie Chai.
Am J Transl Res, 2019 Jul 18; 11(6). PMID: 31312342    Free PMC article.
New Polylactic Acid Multifunctional Ultrasound Contrast Agent Based on Graphene Oxide as the Carrier of Targeted Factor and Drug Delivery.
Jie Zhang, Limei Song, +5 authors, Ying Wang.
ACS Omega, 2019 Aug 29; 4(3). PMID: 31459655    Free PMC article.
The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review.
Hamidur Rahman, Md Rakib Hossain, Tahmina Ferdous.
J Mol Liq, 2020 Oct 06; 320. PMID: 33012931    Free PMC article.
Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment.
Piotr Gierlich, Ana I Mata, +3 authors, Lígia C Gomes-da-Silva.
Molecules, 2020 Nov 19; 25(22). PMID: 33202648    Free PMC article.
Carbon-Based Materials for Photo-Triggered Theranostic Applications.
Karunya Albert, Hsin-Yun Hsu.
Molecules, 2016 Nov 24; 21(11). PMID: 27879628    Free PMC article.
Gadolinium (III) oxide nanoparticles coated with folic acid-functionalized poly(β-cyclodextrin-co-pentetic acid) as a biocompatible targeted nano-contrast agent for cancer diagnostic: in vitro and in vivo studies.
Tohid Mortezazadeh, Elham Gholibegloo, +4 authors, Mehdi Khoobi.
MAGMA, 2019 Feb 08; 32(4). PMID: 30730021
Nanocomposites as biomolecules delivery agents in nanomedicine.
Magdalena Bamburowicz-Klimkowska, Magdalena Poplawska, Ireneusz P Grudzinski.
J Nanobiotechnology, 2019 Apr 05; 17(1). PMID: 30943985    Free PMC article.
Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy.
Lucas D Dias, Ivan S Mfouo-Tynga.
Biomimetics (Basel), 2020 Oct 18; 5(4). PMID: 33066431    Free PMC article.
Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing.
Song Zhang, Jiangtao Shen, Dali Li, Yiyun Cheng.
Theranostics, 2021 Jan 05; 11(2). PMID: 33391496    Free PMC article.
Graphene Oxide Nanoparticle-Loaded Ginsenoside Rg3 Improves Photodynamic Therapy in Inhibiting Malignant Progression and Stemness of Osteosarcoma.
Shou-Liang Lu, Yan-Hua Wang, +4 authors, Cai Cheng.
Front Mol Biosci, 2021 May 11; 8. PMID: 33968991    Free PMC article.
Graphene Oxide Topical Administration: Skin Permeability Studies.
Filipa A L S Silva, Raquel Costa-Almeida, +7 authors, Artur M Pinto.
Materials (Basel), 2021 Jun 03; 14(11). PMID: 34070414    Free PMC article.
Comprehensive Application of Graphene: Emphasis on Biomedical Concerns.
S Syama, P V Mohanan.
Nanomicro Lett, 2019 Jan 12; 11(1). PMID: 34137957    Free PMC article.
Photodynamic Therapy: Targeting Cancer Biomarkers for the Treatment of Cancers.
Xinning Wang, Dong Luo, James P Basilion.
Cancers (Basel), 2021 Jul 03; 13(12). PMID: 34203805    Free PMC article.
Fluorescence Spectroscopy of Porphyrins and Phthalocyanines: Some Insights into Supramolecular Self-Assembly, Microencapsulation, and Imaging Microscopy.
Raquel Teixeira, Vanda Vaz Serra, +3 authors, Sílvia M B Costa.
Molecules, 2021 Jul 25; 26(14). PMID: 34299539    Free PMC article.
Evaluation of the Biological Activity of Folic Acid-Modified Paclitaxel-Loaded Gold Nanoparticles.
Bin Ren, Zhong-Chao Cai, +2 authors, Mei-Xia Zhao.
Int J Nanomedicine, 2021 Oct 28; 16. PMID: 34703225    Free PMC article.
Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction.
Karina J Lagos, Hilde H Buzzá, Vanderlei S Bagnato, María Paulina Romero.
Int J Mol Sci, 2022 Jan 12; 23(1). PMID: 35008458    Free PMC article.
Graphene oxide-ellagic acid nanocomposite as effective anticancer and antimicrobial agent.
Samer Hasan Hussein-Al-Ali, Suha Mujahed Abudoleh, +2 authors, Arul Palanisamy.
IET Nanobiotechnol, 2021 Oct 26; 15(1). PMID: 34694731    Free PMC article.
Graphene-Based Nanomaterials for Biomedical Imaging.
So Yun Lee, Mina Kwon, +3 authors, Ki Su Kim.
Adv Exp Med Biol, 2022 Feb 18; 1351. PMID: 35175615
Reactive Oxygen Species and Folate Receptor-Targeted Nanophotosensitizers Composed of Folic Acid-Conjugated and Poly(ethylene glycol)-Chlorin e6 Tetramer Having Diselenide Linkages for Targeted Photodynamic Treatment of Cancer Cells.
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim.
Int J Mol Sci, 2022 Mar 26; 23(6). PMID: 35328538    Free PMC article.
Microencapsulated Multifunctionalized Graphene Oxide Equipped with Chloroquine for Efficient and Sustained siRNA Delivery.
Rana Imani, Satya Prakash, +2 authors, Shahab Faghihi.
Biomed Res Int, 2022 Apr 27; 2022. PMID: 35469347    Free PMC article.
Magnetic chitosan/graphene oxide composite loaded with novel photosensitizer for enhanced photodynamic therapy.
Xiang Qin, Hongyue Zhang, Zhiqiang Wang, Yingxue Jin.
RSC Adv, 2018 Mar 14; 8(19). PMID: 35540483    Free PMC article.