Journal Article
. 2011 Jun; 71(16):5445-54.
doi: 10.1158/0008-5472.CAN-11-1138.

The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy

Tihui Fu 1 Qiuming He  Padmanee Sharma  
Affiliations
  • PMID: 21708958
  •     94 citations

Abstract

The anti-CTL-associated antigen 4 (anti-CTLA-4) antibody ipilimumab is the first agent to show improved survival in a randomized phase III trial that enrolled patients with metastatic melanoma. Studies are ongoing to identify mechanisms that elicit clinical benefit in the setting of anti-CTLA-4 therapy. We previously reported that treated patients had an increase in the frequency of T cells expressing the inducible costimulator (ICOS) molecule, a T-cell-specific molecule that belongs to the CD28/CTLA-4/B7 immunoglobulin superfamily. ICOS and its ligand (ICOSL) have been shown to play diverse roles in T-cell responses such as mediating autoimmunity as well as enhancing the development/activity of regulatory T cells. These seemingly opposing roles have made it difficult to determine whether the ICOS/ICOSL pathway is necessary for antitumor responses. To determine whether the ICOS/ICOSL pathway might play a causal role in the antitumor effects mediated by anti-CTLA-4, we conducted studies in ICOS-sufficient and ICOS-deficient mice bearing B16/BL6 melanoma. We show that ICOS(+) T cells comprised a population of Th1 cytokine producing and tumor antigen-specific effector cells. Furthermore, in the absence of ICOS, antitumor T-cell responses elicited by anti-CTLA-4 are significantly diminished, thereby impairing tumor rejection. Our findings establish that the ICOS/ICOSL pathway is necessary for the optimal therapeutic effect of anti-CTLA-4, thus implicating this pathway as a target for future combinatorial strategies to improve the efficacy of anti-CTLA-4 therapy.

Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application.
Paolo A Ascierto, Francesco M Marincola, Antoni Ribas.
J Transl Med, 2011 Nov 15; 9. PMID: 22077981    Free PMC article.
Review.
Experimental mouse tumour models: what can be learnt about human cancer immunology?
Glenn Dranoff.
Nat Rev Immunol, 2011 Dec 03; 12(1). PMID: 22134155
Review.
Therapy for metastatic melanoma: the past, present, and future.
Laura Finn, Svetomir N Markovic, Richard W Joseph.
BMC Med, 2012 Mar 06; 10. PMID: 22385436    Free PMC article.
Review.
Targeting costimulatory molecules to improve antitumor immunity.
Daria Capece, Daniela Verzella, +2 authors, Edoardo Alesse.
J Biomed Biotechnol, 2012 Apr 14; 2012. PMID: 22500111    Free PMC article.
Review.
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Wenshi Wang, Daohai Yu, +6 authors, Jeffrey S Weber.
J Transl Med, 2012 Jul 14; 10. PMID: 22788688    Free PMC article.
The role of B7 family molecules in hematologic malignancy.
Paul Greaves, John G Gribben.
Blood, 2012 Dec 12; 121(5). PMID: 23223433    Free PMC article.
Review.
Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity.
W Joost Lesterhuis, Joanne Salmons, +6 authors, Richard A Lake.
PLoS One, 2013 Apr 30; 8(4). PMID: 23626745    Free PMC article.
Identification of potential biomarkers from microarray experiments using multiple criteria optimization.
Matilde L Sánchez-Peña, Clara E Isaza, +3 authors, Mauricio Cabrera-Ríos.
Cancer Med, 2013 May 02; 2(2). PMID: 23634293    Free PMC article.
Ipilimumab, vemurafenib, dabrafenib, and trametinib: synergistic competitors in the clinical management of BRAF mutant malignant melanoma.
Jason J Luke, F Stephen Hodi.
Oncologist, 2013 May 28; 18(6). PMID: 23709751    Free PMC article.
Review.
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.
Jun Li, Jessica Heinrichs, +8 authors, Xue-Zhong Yu.
J Immunol, 2013 Jun 05; 191(1). PMID: 23729441    Free PMC article.
ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+ T cells by plasmacytoid dendritic cells.
Julien Faget, Vanja Sisirak, +3 authors, Christine Ménétrier-Caux.
Oncoimmunology, 2013 Jun 27; 2(3). PMID: 23802069    Free PMC article.
Immunomodulation via Chemotherapy and Targeted Therapy: A New Paradigm in Breast Cancer Therapy?
John Stagg, Fabrice Andre, Sherene Loi.
Breast Care (Basel), 2013 Aug 02; 7(4). PMID: 23904828    Free PMC article.
B7 family checkpoint regulators in immune regulation and disease.
Sabrina Ceeraz, Elizabeth C Nowak, Randolph J Noelle.
Trends Immunol, 2013 Aug 21; 34(11). PMID: 23954143    Free PMC article.
Highly Cited. Review.
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma.
Giulio Tosti, Emilia Cocorocchio, Elisabetta Pennacchioli.
Clin Cosmet Investig Dermatol, 2013 Nov 10; 6. PMID: 24204168    Free PMC article.
Review.
A systems biology approach to personalizing therapeutic combinations.
Lawrence N Kwong, Timothy P Heffernan, Lynda Chin.
Cancer Discov, 2013 Dec 12; 3(12). PMID: 24327696    Free PMC article.
Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.
Susan Achberger, Wayne Aldrich, +3 authors, Pierre L Triozzi.
Mol Immunol, 2013 Dec 29; 58(2). PMID: 24370793    Free PMC article.
Tumor immunology: multidisciplinary science driving basic and clinical advances.
Bridget P Keenan, Elizabeth M Jaffee, Todd D Armstrong.
Cancer Immunol Res, 2014 Jan 11; 1(1). PMID: 24409447    Free PMC article.
Efficacy and safety of ipilimumab therapy in patients with metastatic melanoma: a retrospective multicenter analysis.
Katarzyna Wiater, Tomasz Switaj, +7 authors, Piotr Rutkowski.
Contemp Oncol (Pozn), 2013 Jan 01; 17(3). PMID: 24596511    Free PMC article.
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy.
Xiaozhou Fan, Sergio A Quezada, +2 authors, James P Allison.
J Exp Med, 2014 Apr 02; 211(4). PMID: 24687957    Free PMC article.
Highly Cited.
Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer.
George C Prendergast, Courtney Smith, +4 authors, Alexander J Muller.
Cancer Immunol Immunother, 2014 Apr 09; 63(7). PMID: 24711084    Free PMC article.
Highly Cited. Review.
Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.
Derek Ng Tang, Yu Shen, +5 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 1(4). PMID: 24777852    Free PMC article.
Highly Cited.
Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity.
William L Redmond, Stefanie N Linch, Melissa J Kasiewicz.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778278    Free PMC article.
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy.
Hong Chen, Tihui Fu, +7 authors, Padmanee Sharma.
Cancer Immunol Res, 2014 Apr 30; 2(2). PMID: 24778280    Free PMC article.
Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer.
Raju R Raval, Andrew B Sharabi, +2 authors, Padmanee Sharma.
J Immunother Cancer, 2014 Jun 03; 2. PMID: 24883190    Free PMC article.
Review.
Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells.
Priya Sakthivel, Marcus Gereke, +5 authors, Dunja Bruder.
PLoS One, 2014 Jul 17; 9(7). PMID: 25029240    Free PMC article.
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
F Stephen Hodi, Sandra Lee, +7 authors, John M Kirkwood.
JAMA, 2014 Nov 05; 312(17). PMID: 25369488    Free PMC article.
Highly Cited.
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy.
Joanne Leung, Woong-Kyung Suh.
Immune Netw, 2015 Jan 01; 14(6). PMID: 25550693    Free PMC article.
Review.
The inducible costimulator augments Tc17 cell responses to self and tumor tissue.
Michelle H Nelson, Sreenath Kundimi, +9 authors, Chrystal M Paulos.
J Immunol, 2015 Jan 13; 194(4). PMID: 25576595    Free PMC article.
Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some.
Florencia Paula Madorsky Rowdo, Antonela Baron, Mariela Urrutia, José Mordoh.
Front Immunol, 2015 Apr 11; 6. PMID: 25859247    Free PMC article.
Review.
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine.
Todd Bartkowiak, Shailbala Singh, +6 authors, Michael A Curran.
Proc Natl Acad Sci U S A, 2015 Sep 10; 112(38). PMID: 26351680    Free PMC article.
An Optimization-Driven Analysis Pipeline to Uncover Biomarkers and Signaling Paths: Cervix Cancer.
Enery Lorenzo, Katia Camacho-Caceres, +8 authors, Clara Isaza.
Microarrays (Basel), 2015 Sep 22; 4(2). PMID: 26388997    Free PMC article.
MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints.
Jun Wei, Edjah K Nduom, +13 authors, Amy B Heimberger.
Neuro Oncol, 2015 Dec 15; 18(5). PMID: 26658052    Free PMC article.
Highly Cited.
Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
Susan P Foy, Stefanie J Mandl, +7 authors, Ryan B Rountree.
Cancer Immunol Immunother, 2016 Mar 11; 65(5). PMID: 26961085    Free PMC article.
Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study.
Cristina Maccalli, Diana Giannarelli, +5 authors, Michele Maio.
Oncoimmunology, 2016 Apr 09; 5(2). PMID: 27057436    Free PMC article.
What does the future hold for immunotherapy in cancer?
Jarushka Naidoo, Bob T Li, Katja Schindler, David B Page.
Ann Transl Med, 2016 Jun 09; 4(9). PMID: 27275490    Free PMC article.
Emerging options for the treatment of melanoma - focus on ipilimumab.
Claire Roddie, Karl S Peggs.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27482517    Free PMC article.
Review.
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Jianjun Gao, Lewis Zhichang Shi, +13 authors, Padmanee Sharma.
Cell, 2016 Sep 27; 167(2). PMID: 27667683    Free PMC article.
Highly Cited.
PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques.
Nathan Handley, Jacob Eide, +3 authors, Frank Ondrey.
Laryngoscope, 2016 Nov 30; 127(4). PMID: 27896820    Free PMC article.
Clinical implication of tumor-associated and immunological parameters in melanoma patients treated with ipilimumab.
V Damuzzo, S Solito, +6 authors, S Mandruzzato.
Oncoimmunology, 2017 Jan 27; 5(12). PMID: 28123888    Free PMC article.
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Dmitriy Zamarin, Rikke B Holmgaard, +6 authors, James P Allison.
Nat Commun, 2017 Feb 15; 8. PMID: 28194010    Free PMC article.
Highly Cited.
Immunoregulatory functions of VISTA.
Elizabeth C Nowak, J Louise Lines, +7 authors, Randolph J Noelle.
Immunol Rev, 2017 Mar 05; 276(1). PMID: 28258694    Free PMC article.
Highly Cited. Review.
Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications.
Mariona Cabo, Rienk Offringa, +3 authors, Lorenzo Galluzzi.
Oncoimmunology, 2017 Dec 07; 6(12). PMID: 29209572    Free PMC article.
Review.
Discovery of IDO1 Inhibitors: From Bench to Bedside.
George C Prendergast, William P Malachowski, James B DuHadaway, Alexander J Muller.
Cancer Res, 2017 Dec 17; 77(24). PMID: 29247038    Free PMC article.
Highly Cited. Review.
Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy.
Shivani Srivastava, Stanley R Riddell.
J Immunol, 2018 Jan 10; 200(2). PMID: 29311388    Free PMC article.
Highly Cited. Review.
Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
Yared Hailemichael, Amber Woods, +17 authors, Willem W Overwijk.
J Clin Invest, 2018 Feb 27; 128(4). PMID: 29480817    Free PMC article.
Highly Cited.
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.
Teresa Nguyen, Naze G Avci, +2 authors, Hong Jiang.
Cancers (Basel), 2018 Jun 03; 10(6). PMID: 29857493    Free PMC article.
Review.
Next generation immune-checkpoints for cancer therapy.
Chiara Donini, Lorenzo D'Ambrosio, +2 authors, Dario Sangiolo.
J Thorac Dis, 2018 Jun 29; 10(Suppl 13). PMID: 29951308    Free PMC article.
Review.
Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2.
Ralf Kleef, Ralph Moss, +3 authors, Tibor Bakacs.
Integr Cancer Ther, 2018 Sep 09; 17(4). PMID: 30193538    Free PMC article.
Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity.
Sophie Langdon, Adina Hughes, +8 authors, Charles Sinclair.
Oncoimmunology, 2018 Sep 18; 7(8). PMID: 30221055    Free PMC article.
Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer.
Eric Fox, Thomas Oliver, +5 authors, George C Prendergast.
Front Oncol, 2018 Sep 27; 8. PMID: 30254983    Free PMC article.
Review.
ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity.
Mario Martínez Soldevilla, Helena Villanueva, +10 authors, Fernando Pastor.
Mol Ther, 2019 Aug 14; 27(11). PMID: 31405808    Free PMC article.
CTLA-4 correlates with immune and clinical characteristics of glioma.
Fangkun Liu, Jing Huang, +3 authors, Zhixiong Liu.
Cancer Cell Int, 2020 Jan 09; 20. PMID: 31911758    Free PMC article.
The ICOSL Expression Predicts Better Prognosis for Nasopharyngeal Carcinoma via Enhancing Oncoimmunity.
Geng Zhang, Yi Xu, Sen Zhang, Huifang Zhou.
Biomed Res Int, 2020 Jan 31; 2020. PMID: 31998801    Free PMC article.
Gut Microbiome as a Potential Factor for Modulating Resistance to Cancer Immunotherapy.
Lin Shui, Xi Yang, +3 authors, Hong Zhu.
Front Immunol, 2020 Feb 06; 10. PMID: 32010123    Free PMC article.
Review.
Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade.
Cara L Haymaker, DaeWon Kim, +14 authors, Adi Diab.
Cancer Immunol Res, 2017 Jan 08; 5(2). PMID: 28062513    Free PMC article.
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy.
Lionel B Ivashkiv.
Nat Rev Immunol, 2018 Jun 21; 18(9). PMID: 29921905    Free PMC article.
Highly Cited. Review.
Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan-Kynurenine-Aryl Hydrocarbon Axis.
Brian W Labadie, Riyue Bao, Jason J Luke.
Clin Cancer Res, 2018 Nov 01; 25(5). PMID: 30377198    Free PMC article.
Highly Cited. Review.
IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.
Lidia Yshii, Béatrice Pignolet, +5 authors, Roland Liblau.
JCI Insight, 2019 Apr 05; 4(7). PMID: 30944244    Free PMC article.
B7-CD28 gene family expression is associated with prognostic and immunological characteristics of diffuse large B-cell lymphoma.
Gangjian Wang, Xiaorui Fu, +7 authors, Mingzhi Zhang.
Aging (Albany NY), 2019 Jun 14; 11(12). PMID: 31195368    Free PMC article.
The Infiltration of ICOS+ Cells in Nasopharyngeal Carcinoma is Beneficial for Improved Prognosis.
Geng Zhang, Yi Xu, Huifang Zhou.
Pathol Oncol Res, 2018 Oct 27; 26(1). PMID: 30361907
T cell costimulation, checkpoint inhibitors and anti-tumor therapy.
Dipankar Nandi, Sanmoy Pathak, +6 authors, Vijayamahantesh.
J Biosci, 2020 Apr 30; 45. PMID: 32345776
Review.
Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer.
Clélia Coutzac, Jean-Mehdi Jouniaux, +22 authors, Nathalie Chaput.
Nat Commun, 2020 May 03; 11(1). PMID: 32358520    Free PMC article.
Sindbis Virus with Anti-OX40 Overcomes the Immunosuppressive Tumor Microenvironment of Low-Immunogenic Tumors.
Iris Scherwitzl, Silvana Opp, +5 authors, Daniel Meruelo.
Mol Ther Oncolytics, 2020 Jun 02; 17. PMID: 32478167    Free PMC article.
The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy.
Cinzia Solinas, Chunyan Gu-Trantien, Karen Willard-Gallo.
ESMO Open, 2020 Jun 10; 5(1). PMID: 32516116    Free PMC article.
Review.
Human cancer germline antigen-specific cytotoxic T cell-what can we learn from patient.
Megat Abd Hamid, Yanchun Peng, Tao Dong.
Cell Mol Immunol, 2020 May 27; 17(7). PMID: 32451453    Free PMC article.
Review.
Dose escalation phase 1 study of radiotherapy in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 monoclonal antibody ipilimumab in patients with metastatic melanoma.
Celine Boutros, Nathalie Chaput-Gras, +17 authors, Eric Deutsch.
J Immunother Cancer, 2020 Aug 21; 8(2). PMID: 32819972    Free PMC article.
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Sandra Tuyaerts, Klara Rombauts, +2 authors, Frédéric Amant.
Front Nutr, 2019 Jan 29; 5. PMID: 30687714    Free PMC article.
Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma.
Kai Wen Huang, Kumar Jayant, +4 authors, Mikael H Sodergren.
J Clin Med, 2019 Mar 22; 8(3). PMID: 30893948    Free PMC article.
Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review.
Yolla Haibe, Ziad El Husseini, Rola El Sayed, Ali Shamseddine.
Int J Mol Sci, 2020 Sep 02; 21(17). PMID: 32867025    Free PMC article.
Systematic Review.
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Amanda Hanson, Kutlu Elpek, +16 authors, Christopher J Harvey.
PLoS One, 2020 Sep 25; 15(9). PMID: 32970735    Free PMC article.
Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929).
Diane M Da Silva, Danielle M Enserro, +10 authors, W Martin Kast.
Clin Cancer Res, 2020 Aug 21; 26(21). PMID: 32816895    Free PMC article.
The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas.
Luka de Vos, Ingela Grünwald, +7 authors, Dimo Dietrich.
Epigenetics, 2020 Apr 14; 15(11). PMID: 32281488    Free PMC article.
Overcoming Tumor-Induced Immune Suppression: From Relieving Inhibition to Providing Costimulation with T Cell Agonists.
Dana A Emerson, William L Redmond.
BioDrugs, 2018 Apr 11; 32(3). PMID: 29637478    Free PMC article.
Review.
A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates.
Caroline Jochems, Jo A Tucker, +6 authors, Jeffrey Schlom.
Cancer Immunol Immunother, 2014 Feb 12; 63(4). PMID: 24514956    Free PMC article.
Emerging immunotherapies for metastasis.
Sarah C Edwards, Wilma H M Hoevenaar, Seth B Coffelt.
Br J Cancer, 2020 Dec 03; 124(1). PMID: 33262520    Free PMC article.
Review.
Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
Moshe Lapidot, Abigail E Case, +14 authors, Martin Sattler.
Cancers (Basel), 2020 Dec 31; 13(1). PMID: 33374980    Free PMC article.
Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity.
Allan Relecom, Maysaloun Merhi, +4 authors, Said Dermime.
J Exp Clin Cancer Res, 2021 Feb 20; 40(1). PMID: 33602280    Free PMC article.
Review.
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.
Jongdae Lee, Beatriz Lozano-Ruiz, +3 authors, Jose M González-Navajas.
Front Immunol, 2021 Mar 30; 12. PMID: 33777008    Free PMC article.
Review.
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy.
Kai Tang, Ya-Hong Wu, Yihui Song, Bin Yu.
J Hematol Oncol, 2021 Apr 23; 14(1). PMID: 33883013    Free PMC article.
Review.
Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model.
Mariangela Garofalo, Laura Bertinato, +6 authors, Lukasz Kuryk.
Pharmaceutics, 2021 May 01; 13(4). PMID: 33919827    Free PMC article.
Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?
Justine Cinier, Margaux Hubert, +5 authors, Christine Ménétrier-Caux.
Cancers (Basel), 2021 May 01; 13(8). PMID: 33924428    Free PMC article.
Review.
Clinical Insights Into Novel Immune Checkpoint Inhibitors.
Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim.
Front Pharmacol, 2021 May 25; 12. PMID: 34025438    Free PMC article.
Review.
Construction of a Promising Tumor-Infiltrating CD8+ T Cells Gene Signature to Improve Prediction of the Prognosis and Immune Response of Uveal Melanoma.
Yifang Sun, Jian Wu, +4 authors, Shengsheng Ma.
Front Cell Dev Biol, 2021 Jun 15; 9. PMID: 34124058    Free PMC article.
Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis.
Sara Bjursten, Ankur Pandita, +10 authors, Max Levin.
J Immunother Cancer, 2021 Jul 04; 9(7). PMID: 34215689    Free PMC article.
Sargramostim (rhu GM-CSF) as Cancer Therapy (Systematic Review) and An Immunomodulator. A Drug Before Its Time?
Hillard M Lazarus, Carolyn E Ragsdale, Robert Peter Gale, Gary H Lyman.
Front Immunol, 2021 Sep 07; 12. PMID: 34484202    Free PMC article.
Systematic Review.
Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth.
Anne Marijne Heeren, Jossie Rotman, +7 authors, Tanja D de Gruijl.
J Immunother Cancer, 2021 Oct 27; 9(10). PMID: 34697217    Free PMC article.
Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial.
Patrick A Ott, Matthew Nazzaro, +12 authors, F Stephen Hodi.
J Immunother Cancer, 2021 Nov 14; 9(11). PMID: 34772758    Free PMC article.
Our current understanding of checkpoint inhibitor therapy in cancer immunotherapy.
Elena Goleva, Taras Lyubchenko, +3 authors, Jeffrey A Kern.
Ann Allergy Asthma Immunol, 2021 Mar 16; 126(6). PMID: 33716146    Free PMC article.
Review.
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.
Golnaz Morad, Beth A Helmink, Padmanee Sharma, Jennifer A Wargo.
Cell, 2021 Oct 09; 184(21). PMID: 34624224    Free PMC article.
Review.
Novel Therapeutic Targets and Immune Dysfunction in Malignant Pleural Mesothelioma.
Moshe Lapidot, Srinivas Vinod Saladi, Ravi Salgia, Martin Sattler.
Front Pharmacol, 2022 Jan 25; 12. PMID: 35069219    Free PMC article.
Review.
B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity.
Aubrey S Smith, Hannah M Knochelmann, +11 authors, Chrystal M Paulos.
J Immunother Cancer, 2022 Jan 13; 10(1). PMID: 35017148    Free PMC article.
Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator.
Davide Raineri, Giuseppe Cappellano, +10 authors, Annalisa Chiocchetti.
Biomedicines, 2022 Jan 22; 10(1). PMID: 35052731    Free PMC article.
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Megan M Y Hong, Saman Maleki Vareki.
Cancers (Basel), 2022 Mar 26; 14(6). PMID: 35326731    Free PMC article.
Review.
Neoadjuvant immunotherapy across cancers: meeting report from the Immunotherapy Bridge-December 1st-2nd, 2021.
Elizabeth M Burton, Rodabe N Amaria, +6 authors, Paolo A Ascierto.
J Transl Med, 2022 Jun 16; 20(1). PMID: 35706041