. 2011 Jul;13(3).
doi: 10.1186/bcr2890.

Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction

Pierre-Emmanuel Colombo 1 Fernanda Milanezi  Britta Weigelt  Jorge S Reis-Filho  
  • PMID: 21787441
  •     111 References
  •     49 citations


Breast cancer comprises a collection of diseases with distinctive clinical, histopathological, and molecular features. Importantly, tumors with similar histological features may display disparate clinical behaviors. Gene expression profiling using microarray technologies has improved our understanding of breast cancer biology and has led to the development of a breast cancer molecular taxonomy and of multigene 'signatures' to predict outcome and response to systemic therapies. The use of these prognostic and predictive signatures in routine clinical decision-making remains controversial. Here, we review the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management.

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Nat Rev Drug Discov, 2012 Jun 02; 11(6). PMID: 22653217
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Prognostic signatures in breast cancer: correlation does not imply causation.
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Breast Cancer Res, 2012 Jun 21; 14(3). PMID: 22713235    Free PMC article.
Stromal genes add prognostic information to proliferation and histoclinical markers: a basis for the next generation of breast cancer gene signatures.
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PLoS One, 2012 Jun 22; 7(6). PMID: 22719844    Free PMC article.
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Oncogene, 2012 Jul 25; 32(25). PMID: 22824793    Free PMC article.
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Clinics (Sao Paulo), 2012 Oct 17; 67(10). PMID: 23070345    Free PMC article.
Transcriptional shift identifies a set of genes driving breast cancer chemoresistance.
Laura Vera-Ramirez, Pedro Sanchez-Rovira, +3 authors, Jose A Lorente.
PLoS One, 2013 Jan 18; 8(1). PMID: 23326553    Free PMC article.
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Cancer Prev Res (Phila), 2013 Mar 01; 6(5). PMID: 23447563    Free PMC article.
A prognosis classifier for breast cancer based on conserved gene regulation between mammary gland development and tumorigenesis: a multiscale statistical model.
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PLoS One, 2013 Apr 09; 8(4). PMID: 23565194    Free PMC article.
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J Interferon Cytokine Res, 2013 May 24; 33(10). PMID: 23697558    Free PMC article.
Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection.
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PLoS One, 2013 Jul 05; 8(6). PMID: 23824656    Free PMC article.
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PLoS One, 2013 Jul 23; 8(7). PMID: 23875016    Free PMC article.
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PLoS One, 2013 Aug 13; 8(7). PMID: 23936250    Free PMC article.
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Proc Natl Acad Sci U S A, 2013 Nov 10; 110(48). PMID: 24204030    Free PMC article.
Are breast cancer molecular classes predictive of survival in patients with long follow-up?
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Dis Markers, 2013 Nov 30; 35(6). PMID: 24288429    Free PMC article.
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Cancer Epidemiol Biomarkers Prev, 2014 Feb 14; 23(5). PMID: 24521995    Free PMC article.
A novel approach for discovering condition-specific correlations of gene expressions within biological pathways by using cloud computing technology.
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Comput Struct Biotechnol J, 2013 Jan 01; 6. PMID: 24688711    Free PMC article.
The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.
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Mol Biol Rep, 2014 Oct 17; 42(2). PMID: 25318895
MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer.
Ruiguang Zhang, Yan Li, +2 authors, Xiu Nie.
Med Oncol, 2014 Nov 25; 31(12). PMID: 25416050
Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma.
Jeff P Bruce, Angela B Y Hui, +12 authors, Fei-Fei Liu.
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Fuzzy logic selection as a new reliable tool to identify molecular grade signatures in breast cancer--the INNODIAG study.
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BMC Med Genomics, 2015 Apr 19; 8. PMID: 25888889    Free PMC article.
The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set.
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PLoS One, 2015 Jul 02; 10(7). PMID: 26132585    Free PMC article.
GESearch: An Interactive GUI Tool for Identifying Gene Expression Signature.
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Breast Cancer Res Treat, 2015 Sep 16; 153(3). PMID: 26369534    Free PMC article.
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Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production.
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Tumour Biol, 2016 Aug 04; 37(10). PMID: 27485113
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First report on molecular breast cancer subtypes and their clinico-pathological characteristics in Eastern Morocco: series of 2260 cases.
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Gene Expression Signatures for Head and Neck Cancer Patient Stratification: Are Results Ready for Clinical Application?
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Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview.
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Dipalmitoylphosphatidic acid inhibits tumor growth in triple-negative breast cancer.
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Profiling of gene expression regulated by 17β-estradiol and tamoxifen in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines.
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SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment.
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GSIAR: gene-subcategory interaction-based improved deep representation learning for breast cancer subcategorical analysis using gene expression, applicable for precision medicine.
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Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(γ) signaling pathway.
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Six novel immunoglobulin genes as biomarkers for better prognosis in triple-negative breast cancer by gene co-expression network analysis.
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Sci Rep, 2019 Mar 16; 9(1). PMID: 30872752    Free PMC article.
Network modeling of patients' biomolecular profiles for clinical phenotype/outcome prediction.
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SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment.
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Epidemiological characteristics, clinical outcomes and management patterns of metastatic breast cancer patients in routine clinical care settings of Greece: Results from the EMERGE multicenter retrospective chart review study.
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