Journal Article
. 2011 Aug;17(18).
doi: 10.1158/1078-0432.CCR-11-0926.

A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors

Martin Filipits 1 Margaretha Rudas  Raimund Jakesz  Peter Dubsky  Florian Fitzal  Christian F Singer  Otto Dietze  Richard Greil  Andrea Jelen  Paul Sevelda  Christa Freibauer  Volkmar Müller  Fritz Jänicke  Marcus Schmidt  Heinz Kölbl  Achim Rody  Manfred Kaufmann  Werner Schroth  Hiltrud Brauch  Matthias Schwab  Peter Fritz  Karsten E Weber  Inke S Feder  Guido Hennig  Ralf Kronenwett  Mathias Gehrmann  Michael Gnant  EP Investigators  
Affiliations
  • PMID: 21807638
  •     195 citations

Abstract

Purpose: According to current guidelines, molecular tests predicting the outcome of breast cancer patients can be used to assist in making treatment decisions after consideration of conventional markers. We developed and validated a gene expression signature predicting the likelihood of distant recurrence in patients with estrogen receptor (ER)-positive, HER2-negative breast cancer treated with adjuvant endocrine therapy.

Experimental Design: RNA levels assessed by quantitative reverse transcriptase PCR in formalin-fixed, paraffin-embedded tumor tissue were used to calculate a risk score (Endopredict, EP) consisting of eight cancer-related and three reference genes. EP was combined with nodal status and tumor size into a comprehensive risk score, EPclin. Both prespecified risk scores including cutoff values to determine a risk group for each patient (low and high) were validated independently in patients from two large randomized phase III trials [Austrian Breast and Colorectal Cancer Study Group (ABCSG)-6: n = 378, ABCSG-8: n = 1,324].

Results: In both validation cohorts, continuous EP was an independent predictor of distant recurrence in multivariate analysis (ABCSG-6: P = 0.010, ABCSG-8: P < 0.001). Combining Adjuvant!Online, quantitative ER, Ki67, and treatment with EP yielded a prognostic power significantly superior to the clinicopathologic factors alone [c-indices: 0.764 vs. 0.750, P = 0.024 (ABCSG-6) and 0.726 vs. 0.701, P = 0.003 (ABCSG-8)]. EPclin had c-indices of 0.788 and 0.732 and resulted in 10-year distant recurrence rates of 4% and 4% in EPclin low-risk and 28% and 22% in EPclin high-risk patients in ABCSG-6 (P < 0.001) and ABCSG-8 (P < 0.001), respectively.

Conclusions: The multigene EP risk score provided additional prognostic information to the risk of distant recurrence of breast cancer patients, independent from clinicopathologic parameters. The EPclin score outperformed all conventional clinicopathologic risk factors.

External validation of Adjuvant! Online breast cancer prognosis tool. Prioritising recommendations for improvement.
David Hajage, Yann de Rycke, +11 authors, Fabien Reyal.
PLoS One, 2011 Nov 17; 6(11). PMID: 22087319    Free PMC article.
Decentral gene expression analysis for ER+/Her2- breast cancer: results of a proficiency testing program for the EndoPredict assay.
Carsten Denkert, Ralf Kronenwett, +23 authors, Manfred Dietel.
Virchows Arch, 2012 Mar 01; 460(3). PMID: 22371223    Free PMC article.
Comparison of the RNA-based EndoPredict multigene test between core biopsies and corresponding surgical breast cancer sections.
Berit Maria Müller, Jan C Brase, +7 authors, Carsten Denkert.
J Clin Pathol, 2012 Mar 27; 65(7). PMID: 22447922    Free PMC article.
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
Zonglin Chen, Aslihan Gerhold-Ay, +13 authors, Marcus Schmidt.
PLoS One, 2012 Oct 03; 7(9). PMID: 23028600    Free PMC article.
EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer.
P Dubsky, M Filipits, +17 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG).
Ann Oncol, 2012 Oct 05; 24(3). PMID: 23035151    Free PMC article.
Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test.
Ralf Kronenwett, Kerstin Bohmann, +16 authors, Carsten Denkert.
BMC Cancer, 2012 Oct 09; 12. PMID: 23039280    Free PMC article.
[Translational research and diagnostics for breast cancer].
H H Kreipe.
Pathologe, 2012 Oct 16; 33 Suppl 2. PMID: 23064514
Review.
Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization.
Jan Budczies, Frederick Klauschen, +4 authors, Carsten Denkert.
PLoS One, 2012 Dec 20; 7(12). PMID: 23251644    Free PMC article.
Highly Cited.
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
H A Azim, S Michiels, +9 authors, C Swanton.
Ann Oncol, 2013 Jan 23; 24(3). PMID: 23337633    Free PMC article.
HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer.
Carsten Denkert, Jens Huober, +14 authors, Michael Untch.
Breast Cancer Res, 2013 Feb 09; 15(1). PMID: 23391338    Free PMC article.
Comparison of EndoPredict and Oncotype DX test results in hormone receptor positive invasive breast cancer.
Zsuzsanna Varga, Peter Sinn, +6 authors, Holger Moch.
PLoS One, 2013 Mar 19; 8(3). PMID: 23505515    Free PMC article.
Long-term analysis to objectify the tumour grading by means of automated microscopic image analysis of the nucleolar organizer regions (AgNORs) in the case of breast carcinoma.
Klaus-Jürgen Winzer, Joachim Bellach, Peter Hufnagl.
Diagn Pathol, 2013 Apr 10; 8. PMID: 23566354    Free PMC article.
The EndoPredict Gene-Expression Assay in Clinical Practice - Performance and Impact on Clinical Decisions.
Berit Maria Müller, Elke Keil, +16 authors, Carsten Denkert.
PLoS One, 2013 Jul 05; 8(6). PMID: 23826382    Free PMC article.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Review.
[Gene expression analysis in breast cancer. A new diagnostic tool in pathology].
C Denkert.
Pathologe, 2013 Aug 13; 34(5). PMID: 23934410
Review.
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.
Xi Zhang, Xin Mu, +4 authors, Kunwei Shen.
PLoS One, 2013 Aug 31; 8(8). PMID: 23991038    Free PMC article.
Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers.
Giampaolo Bianchini, Lajos Pusztai, +16 authors, Luca Gianni.
Breast Cancer Res, 2013 Sep 26; 15(5). PMID: 24060333    Free PMC article.
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.
Trine Tramm, Guido Hennig, +5 authors, Jens Overgaard.
Virchows Arch, 2013 Oct 09; 463(6). PMID: 24100522
The EndoPredict score provides prognostic information on late distant metastases in ER+/HER2- breast cancer patients.
P Dubsky, J C Brase, +18 authors, Austrian Breast and Colorectal Cancer Study Group (ABCSG).
Br J Cancer, 2013 Oct 26; 109(12). PMID: 24157828    Free PMC article.
Highly Cited.
An unmet need: tailoring extended adjuvant endocrine therapy.
G Bianchini, L Gianni.
Br J Cancer, 2013 Nov 21; 109(12). PMID: 24253504    Free PMC article.
AGO Recommendations for Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2013.
Anton Scharl, Christoph Thomssen, Nadia Harbeck, Volkmar Müller.
Breast Care (Basel), 2014 Jan 15; 8(3). PMID: 24415966    Free PMC article.
Breast Cancer Biomarkers: Utility in Clinical Practice.
Fanny Le Du, Naoto T Ueno, Ana M Gonzalez-Angulo.
Curr Breast Cancer Rep, 2014 Jan 15; 5(4). PMID: 24416469    Free PMC article.
Molecular tests as prognostic factors in breast cancer.
Marc J van de Vijver.
Virchows Arch, 2014 Feb 04; 464(3). PMID: 24487789
Review.
Genomic profiling in luminal breast cancer.
Oleg Gluz, Daniel Hofmann, +3 authors, Nadia Harbeck.
Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550749    Free PMC article.
Review.
Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens.
Torsten Nielsen, Brett Wallden, +7 authors, James Storhoff.
BMC Cancer, 2014 Mar 15; 14. PMID: 24625003    Free PMC article.
Highly Cited.
Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients.
Nicholas P Tobin, Linda S Lindström, +3 authors, Kristian Wennmalm.
Mol Oncol, 2014 Mar 19; 8(3). PMID: 24630985    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Adaptive designs for clinical trials assessing biomarker-guided treatment strategies.
J Wason, A Marshall, +2 authors, N Stallard.
Br J Cancer, 2014 Mar 29; 110(8). PMID: 24667651    Free PMC article.
Relevance of Health Economics in the Medical Treatment of Breast Cancer: The View of the Professional Association of Practicing Gynecologic Oncologists e.V. (BNGO).
Georg Heinrich, Hindenburg Hans-Joachim, Jörg Schilling, Peter Klare.
Breast Care (Basel), 2014 Apr 10; 8(1). PMID: 24715840    Free PMC article.
Review.
Clinical validation of the EndoPredict test in node-positive, chemotherapy-treated ER+/HER2- breast cancer patients: results from the GEICAM 9906 trial.
Miguel Martin, Jan C Brase, +15 authors, Alvaro Rodriguez-Lescure.
Breast Cancer Res, 2014 Apr 15; 16(2). PMID: 24725534    Free PMC article.
Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility.
P Sinn, S Aulmann, +6 authors, A Schneeweiss.
Geburtshilfe Frauenheilkd, 2014 Apr 29; 73(9). PMID: 24771945    Free PMC article.
Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer.
Sarah E Holton, Anna Bergamaschi, Benita S Katzenellenbogen, Rohit Bhargava.
PLoS One, 2014 May 13; 9(5). PMID: 24816718    Free PMC article.
Modern Risk Assessment for Individualizing Treatment Concepts in Early-stage Breast Cancer.
Alex Farr, Rachel Wuerstlein, +2 authors, Nadia Harbeck.
Rev Obstet Gynecol, 2013 Jan 01; 6(3-4). PMID: 24920978    Free PMC article.
Late recurrences in early breast cancer: for whom and how long is endocrine therapy beneficial?
Michael Knauer, Martin Filipits, Peter Dubsky.
Breast Care (Basel), 2014 Jun 20; 9(2). PMID: 24944551    Free PMC article.
Review.
Chemotherapy in early breast cancer: when, how and which one?
Marcus Schmidt.
Breast Care (Basel), 2014 Sep 02; 9(3). PMID: 25177256    Free PMC article.
Review.
Preanalytical variables and performance of diagnostic RNA-based gene expression analysis in breast cancer.
Christopher Poremba, Jennifer Uhlendorff, +10 authors, Carsten Denkert.
Virchows Arch, 2014 Sep 15; 465(4). PMID: 25218890    Free PMC article.
Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients.
Isabel Sicking, Karolina Edlund, +10 authors, Marcus Schmidt.
PLoS One, 2014 Oct 24; 9(10). PMID: 25340395    Free PMC article.
Cost-effectiveness analysis of prognostic gene expression signature-based stratification of early breast cancer patients.
Patricia R Blank, Martin Filipits, +11 authors, Michael Gnant.
Pharmacoeconomics, 2014 Nov 19; 33(2). PMID: 25404424    Free PMC article.
Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology.
Debora Fumagalli, Alexis Blanchet-Cohen, +13 authors, Benjamin Haibe-Kains.
BMC Genomics, 2014 Nov 22; 15. PMID: 25412710    Free PMC article.
Emerging gene-based prognostic tools in early breast cancer: First steps to personalised medicine.
Umar Wazir, Kefah Mokbel.
World J Clin Oncol, 2014 Dec 11; 5(5). PMID: 25493218    Free PMC article.
Study of integrated heterogeneous data reveals prognostic power of gene expression for breast cancer survival.
Richard E Neapolitan, Xia Jiang.
PLoS One, 2015 Feb 28; 10(2). PMID: 25723490    Free PMC article.
Ki67--no evidence for its use in node-positive breast cancer.
Fabrice Andre, Monica Arnedos, +2 authors, Suzette Delaloge.
Nat Rev Clin Oncol, 2015 Mar 18; 12(5). PMID: 25781576
Review.
Breast Cancer Update 2014 - Focus on the Patient and the Tumour.
N Maass, F Schütz, +7 authors, M P Lux.
Geburtshilfe Frauenheilkd, 2015 Mar 24; 75(2). PMID: 25797960    Free PMC article.
[Molecular pathology for breast cancer: Importance of the gene expression profile].
C Denkert, B M Pfitzner, B I Heppner, M Dietel.
Pathologe, 2015 Apr 04; 36(2). PMID: 25836324
Review.
Multigene prognostic tests in breast cancer: past, present, future.
Balázs Győrffy, Christos Hatzis, +3 authors, Lajos Pusztai.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848861    Free PMC article.
Highly Cited. Review.
Markers for the identification of late breast cancer recurrence.
Ivana Sestak, Jack Cuzick.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25848913    Free PMC article.
Review.
Molecular subtyping for clinically defined breast cancer subgroups.
Xi Zhao, Einar Andreas Rødland, Robert Tibshirani, Sylvia Plevritis.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849221    Free PMC article.
The genomic expression test EndoPredict is a prognostic tool for identifying risk of local recurrence in postmenopausal endocrine receptor-positive, her2neu-negative breast cancer patients randomised within the prospective ABCSG 8 trial.
F Fitzal, M Filipits, +9 authors, M Gnant.
Br J Cancer, 2015 Apr 14; 112(8). PMID: 25867274    Free PMC article.
Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer.
Andrew E Teschendorff, Linlin Li, Zhen Yang.
Genome Biol, 2015 Apr 18; 16. PMID: 25886003    Free PMC article.
Developing a new generation of breast cancer clinical gene expression tests.
Zuzana Kos, Torsten O Nielsen.
Breast Cancer Res, 2014 Jan 01; 16(4). PMID: 25928431    Free PMC article.
Gene profiling and circulating tumor cells as biomarker to prognostic of patients with locoregional breast cancer.
Renata K Kuniyoshi, Flávia de Sousa Gehrke, +6 authors, Auro Del Giglio.
Tumour Biol, 2015 May 16; 36(10). PMID: 25976504
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis.
Zhanwei Wang, Dionyssios Katsaros, +7 authors, Herbert Yu.
PLoS One, 2015 Aug 20; 10(8). PMID: 26287798    Free PMC article.
Development and verification of the PAM50-based Prosigna breast cancer gene signature assay.
Brett Wallden, James Storhoff, +16 authors, Joel S Parker.
BMC Med Genomics, 2015 Aug 25; 8. PMID: 26297356    Free PMC article.
Highly Cited.
A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.
M Dietel, K Jöhrens, +12 authors, I Anagnostopoulos.
Cancer Gene Ther, 2015 Sep 12; 22(9). PMID: 26358176
Review.
SEOM clinical guidelines in early-stage breast cancer 2015.
J A Garcia-Saenz, B Bermejo, +7 authors, E Ciruelos.
Clin Transl Oncol, 2015 Oct 27; 17(12). PMID: 26497356    Free PMC article.
Using second harmonic generation to predict patient outcome in solid tumors.
K Burke, M Smid, +6 authors, E Brown.
BMC Cancer, 2015 Nov 26; 15. PMID: 26603532    Free PMC article.
Biomarkers in Breast Cancer - An Update.
M Schmidt, P A Fasching, M W Beckmann, H Kölbl.
Geburtshilfe Frauenheilkd, 2012 Sep 01; 72(9). PMID: 26640290    Free PMC article.
[Determination of prognosis using gene expression analyses: Consequences for the indication for radiotherapy?].
René Baumann, David Krug.
Strahlenther Onkol, 2015 Dec 10; 192(2). PMID: 26646310
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline.
Lyndsay N Harris, Nofisat Ismaila, +11 authors, American Society of Clinical Oncology.
J Clin Oncol, 2016 Feb 10; 34(10). PMID: 26858339    Free PMC article.
Highly Cited. Review.
Changing molecular profile of brain metastases compared with matched breast primary cancers and impact on clinical outcomes.
A H Thomson, J McGrane, +4 authors, R Jenkins.
Br J Cancer, 2016 Feb 26; 114(7). PMID: 26908328    Free PMC article.
Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study.
Miguel Martin, Jan C Brase, +15 authors, Alvaro Rodriguez-Lescure.
Breast Cancer Res Treat, 2016 Feb 26; 156(1). PMID: 26909792    Free PMC article.
Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors.
Marion Lapierre, Aurélien Linares, +13 authors, Vincent Cavaillès.
Oncotarget, 2016 Mar 02; 7(15). PMID: 26930713    Free PMC article.
Equivalence of MammaPrint array types in clinical trials and diagnostics.
Inès Beumer, Anke Witteveen, +11 authors, Annuska Glas.
Breast Cancer Res Treat, 2016 Mar 24; 156(2). PMID: 27002507    Free PMC article.
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
Srividya Vaidyanathan, Pulari U Thangavelu, Pascal H G Duijf.
Target Oncol, 2016 Mar 30; 11(5). PMID: 27023921
Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information.
Zhenyu Yue, Hai-Tao Li, +4 authors, Yan Chen.
Oncotarget, 2016 May 07; 7(24). PMID: 27150055    Free PMC article.
Intratumor Heterogeneity Affects Gene Expression Profile Test Prognostic Risk Stratification in Early Breast Cancer.
Rekha Gyanchandani, Yan Lin, +10 authors, Adrian V Lee.
Clin Cancer Res, 2016 Nov 03; 22(21). PMID: 27185370    Free PMC article.
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer.
Nikiana Simigdala, Qiong Gao, +8 authors, Lesley-Ann Martin.
Breast Cancer Res, 2016 Jun 02; 18(1). PMID: 27246191    Free PMC article.
Breast cancer: The 21-gene recurrence score - biology remains at the forefront.
Shannon L Puhalla, Nancy E Davidson.
Nat Rev Clin Oncol, 2016 Jun 15; 13(8). PMID: 27296295
Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies.
Dominic A Pearce, Laura M Arthur, +6 authors, Andrew H Sims.
Sci Rep, 2016 Jul 08; 6. PMID: 27384960    Free PMC article.
Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy.
Richard Buus, Ivana Sestak, +7 authors, Mitch Dowsett.
J Natl Cancer Inst, 2016 Jul 13; 108(11). PMID: 27400969    Free PMC article.
Highly Cited.
The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures.
Jessica G Cockburn, Robin M Hallett, +5 authors, Anita Bane.
BMC Cancer, 2016 Jul 30; 16. PMID: 27469239    Free PMC article.
The 3'UTR signature defines a highly metastatic subgroup of triple-negative breast cancer.
Lei Wang, Xin Hu, Peng Wang, Zhi-Ming Shao.
Oncotarget, 2016 Aug 06; 7(37). PMID: 27494850    Free PMC article.
From High-Throughput Microarray-Based Screening to Clinical Application: The Development of a Second Generation Multigene Test for Breast Cancer Prognosis.
Jan C Brase, Ralf Kronenwett, +2 authors, Marcus Schmidt.
Microarrays (Basel), 2013 Jan 01; 2(3). PMID: 27605191    Free PMC article.
Review.
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Sylvain Delaunay, Francesca Rapino, +14 authors, Pierre Close.
J Exp Med, 2016 Nov 05; 213(11). PMID: 27811057    Free PMC article.
Double-edged role of G protein-coupled estrogen receptor 1 in breast cancer prognosis: an analysis of 167 breast cancer samples and online data sets.
Fan Yang, Zhi-Min Shao.
Onco Targets Ther, 2016 Nov 09; 9. PMID: 27822058    Free PMC article.
Hormonal Modulation of Breast Cancer Gene Expression: Implications for Intrinsic Subtyping in Premenopausal Women.
Sarah M Bernhardt, Pallave Dasari, +3 authors, Wendy V Ingman.
Front Oncol, 2016 Nov 30; 6. PMID: 27896218    Free PMC article.
Review.
Factors Influencing Decision-Making for or against Adjuvant and Neoadjuvant Chemotherapy in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients in the EvAluate-TM Study.
Paul Gaß, Peter A Fasching, +47 authors, Christian R Löhberg.
Breast Care (Basel), 2016 Dec 07; 11(5). PMID: 27920623    Free PMC article.
Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays.
David M Hyams, Eric Schuur, +7 authors, Aníbal Nuñez De Pierro.
J Surg Oncol, 2017 Feb 18; 115(6). PMID: 28211064    Free PMC article.
Review.
A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2- early breast cancer.
Gyungyub Gong, Mi Jeong Kwon, +15 authors, Young Kee Shin.
Sci Rep, 2017 Mar 30; 7. PMID: 28350001    Free PMC article.
Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue.
Bojana Jovanović, Quanhu Sheng, +8 authors, Brian D Lehmann.
BMC Cancer, 2017 Apr 06; 17(1). PMID: 28376728    Free PMC article.
A 3q gene signature associated with triple negative breast cancer organ specific metastasis and response to neoadjuvant chemotherapy.
Jun Qian, Heidi Chen, +4 authors, Pierre P Massion.
Sci Rep, 2017 Apr 08; 7. PMID: 28387221    Free PMC article.
S100β as a serum marker in endocrine resistant breast cancer.
Sara Charmsaz, Éamon Hughes, +10 authors, Leonie S Young.
BMC Med, 2017 Apr 13; 15(1). PMID: 28399921    Free PMC article.
MMP11 and CD2 as novel prognostic factors in hormone receptor-negative, HER2-positive breast cancer.
Jinil Han, Yoon-La Choi, +11 authors, Young Kee Shin.
Breast Cancer Res Treat, 2017 Apr 15; 164(1). PMID: 28409241    Free PMC article.
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets.
Sebastien Lemieux, Tobias Sargeant, +10 authors, Guy Sauvageau.
Nucleic Acids Res, 2017 May 05; 45(13). PMID: 28472340    Free PMC article.
Clinical utility of gene-expression signatures in early stage breast cancer.
Maryann Kwa, Andreas Makris, Francisco J Esteva.
Nat Rev Clin Oncol, 2017 Jun 01; 14(10). PMID: 28561071
Highly Cited. Review.
Tamoxifen therapy benefit for patients with 70-gene signature high and low risk.
Laura J van 't Veer, Christina Yau, +6 authors, Linda Sofie Lindström.
Breast Cancer Res Treat, 2017 Aug 05; 166(2). PMID: 28776283    Free PMC article.
How to Achieve Optimal Care in Early Breast Cancer with 'Less' or 'More' Treatment.
Giuseppe Curigliano.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785179    Free PMC article.
Extended Adjuvant Endocrine Therapy in Hormone Receptor-Positive Early Breast Cancer.
Dara B Bracken-Clarke, Mairi W Lucas, Michaela J Higgins.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785180    Free PMC article.
Review.
Identifying Biomarkers to Select Patients with Early Breast Cancer Suitable for Extended Adjuvant Endocrine Therapy.
Ivana Sestak.
Breast Care (Basel), 2017 Aug 09; 12(3). PMID: 28785181    Free PMC article.
Review.
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017.
G Curigliano, H J Burstein, +52 authors, B Xu.
Ann Oncol, 2017 Aug 26; 28(8). PMID: 28838210    Free PMC article.
Highly Cited.
MammaPrint versus EndoPredict: Poor correlation in disease recurrence risk classification of hormone receptor positive breast cancer.
Andreas Bösl, Andreas Spitzmüller, +3 authors, Felix Offner.
PLoS One, 2017 Aug 30; 12(8). PMID: 28850621    Free PMC article.
Decision impact and feasibility of different ASCO-recommended biomarkers in early breast cancer: Prospective comparison of molecular marker EndoPredict and protein marker uPA/PAI-1.
Johannes Ettl, Evelyn Klein, +7 authors, Marion Kiechle.
PLoS One, 2017 Sep 07; 12(9). PMID: 28877230    Free PMC article.
Analytical validation of a 12-gene molecular test for the prediction of distant recurrence in breast cancer.
M Bryan Warf, Saradha Rajamani, +6 authors, Benjamin B Roa.
Future Sci OA, 2017 Sep 09; 3(3). PMID: 28884016    Free PMC article.
Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer.
Alberto Peláez-García, Laura Yébenes, +9 authors, David Hardisson.
PLoS One, 2017 Sep 09; 12(9). PMID: 28886093    Free PMC article.
Clinical outcomes in patients with node-negative breast cancer treated based on the recurrence score results: evidence from a large prospectively designed registry.
Salomon M Stemmer, Mariana Steiner, +21 authors, Nicky Liebermann.
NPJ Breast Cancer, 2017 Sep 14; 3. PMID: 28900633    Free PMC article.
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts.
Arian Lundberg, Linda S Lindström, +8 authors, Nicholas P Tobin.
Clin Cancer Res, 2017 Oct 04; 23(24). PMID: 28972043    Free PMC article.
Use of 21-gene recurrence score assay to individualize adjuvant chemotherapy recommendations in ER+/HER2- node positive breast cancer-A National Cancer Database study.
Prema P Peethambaram, Tanya L Hoskin, +3 authors, Judy C Boughey.
NPJ Breast Cancer, 2017 Oct 27; 3. PMID: 29067357    Free PMC article.
Gene Expression Profiling in Breast Cancer and Its Effect on Therapy Selection in Early-Stage Breast Cancer.
E Nilüfer Güler.
Eur J Breast Health, 2017 Oct 31; 13(4). PMID: 29082373    Free PMC article.
Review.
Clinical utility of multigene profiling assays in early-stage breast cancer.
M C Chang, L H Souter, +6 authors, Molecular Oncology Advisory Committee.
Curr Oncol, 2017 Nov 02; 24(5). PMID: 29089811    Free PMC article.
Assessing the Clinical Benefit of Systemic Adjuvant Therapies for Early Breast Cancer.
Volker Möbus, Susanne Hell, Marcus Schmidt.
Geburtshilfe Frauenheilkd, 2017 Nov 03; 77(10). PMID: 29093601    Free PMC article.
Gene expression information improves reliability of receptor status in breast cancer patients.
Michael Kenn, Karin Schlangen, +4 authors, Wolfgang Schreiner.
Oncotarget, 2017 Nov 05; 8(44). PMID: 29100391    Free PMC article.
Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up.
Hege O Ohnstad, Elin Borgen, +11 authors, Bjørn Naume.
Breast Cancer Res, 2017 Nov 16; 19(1). PMID: 29137653    Free PMC article.
A tissue microRNA signature that predicts the prognosis of breast cancer in young women.
Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, +10 authors, Takahiro Ochiya.
PLoS One, 2017 Nov 16; 12(11). PMID: 29141042    Free PMC article.
Neoadjuvant palbociclib on ER+ breast cancer (N007): clinical response and EndoPredict's value.
Louis W C Chow, Satoshi Morita, +2 authors, Masakazu Toi.
Endocr Relat Cancer, 2017 Nov 22; 25(2). PMID: 29158285    Free PMC article.
Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology.
R Colomer, I Aranda-López, +7 authors, J Palacios-Calvo.
Clin Transl Oncol, 2017 Dec 24; 20(7). PMID: 29273958    Free PMC article.
Review.
Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies.
Peng Jiang, Winston Lee, +5 authors, X Shirley Liu.
Cell Syst, 2018 Feb 13; 6(3). PMID: 29428415    Free PMC article.
Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Ivana Sestak, Richard Buus, +9 authors, Mitch Dowsett.
JAMA Oncol, 2018 Feb 17; 4(4). PMID: 29450494    Free PMC article.
Highly Cited.
Spotlight on the utility of the Oncotype DX® breast cancer assay.
Zhen Rong Siow, Richard H De Boer, Geoffrey J Lindeman, G Bruce Mann.
Int J Womens Health, 2018 Mar 06; 10. PMID: 29503586    Free PMC article.
Review.
Prognostic & predictive factors for planning adjuvant chemotherapy of early-stage breast cancer.
Onur Esbah, Berna Oksuzoglu.
Indian J Med Res, 2018 Mar 08; 146(5). PMID: 29512598    Free PMC article.
Review.
Understanding Biomarkers in Early-Stage Invasive Breast Cancer: Tools From the ASCO Clinical Guideline.
Kelley D Mayden.
J Adv Pract Oncol, 2016 Sep 01; 7(6). PMID: 29588871    Free PMC article.
Review.
Stanniocalcin Expression as a Predictor of Late Breast Cancer Recurrence.
Kristen D Brantley, Anders Kjærsgaard, +5 authors, Timothy L Lash.
Cancer Epidemiol Biomarkers Prev, 2018 Mar 30; 27(6). PMID: 29593009    Free PMC article.
Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5.
Mitch Dowsett, Ivana Sestak, +5 authors, Jack Cuzick.
J Clin Oncol, 2018 Apr 21; 36(19). PMID: 29676944    Free PMC article.
Genes and functions from breast cancer signatures.
Shujun Huang, Leigh Murphy, Wayne Xu.
BMC Cancer, 2018 Apr 28; 18(1). PMID: 29699511    Free PMC article.
Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling.
S Aggarwal, A Vaid, +10 authors, D Doval.
South Asian J Cancer, 2018 May 04; 7(2). PMID: 29721472    Free PMC article.
Conventional Pathology Versus Gene Signatures for Assessing Luminal A and B Type Breast Cancers: Results of a Prospective Cohort Study.
Julia E C van Steenhoven, Anne Kuijer, +12 authors, Thijs van Dalen.
Genes (Basel), 2018 May 19; 9(5). PMID: 29772837    Free PMC article.
Addressing the challenges of applying precision oncology.
Seung Ho Shin, Ann M Bode, Zigang Dong.
NPJ Precis Oncol, 2018 Jun 07; 1(1). PMID: 29872710    Free PMC article.
Review.
Clinical application and utility of genomic assays in early-stage breast cancer: key lessons learned to date.
S K L Chia.
Curr Oncol, 2018 Jun 19; 25(Suppl 1). PMID: 29910655    Free PMC article.
Review.
Gene expression assay and Watson for Oncology for optimization of treatment in ER-positive, HER2-negative breast cancer.
Yun Yeong Kim, Se Jeong Oh, +2 authors, Heung Kyu Park.
PLoS One, 2018 Jul 07; 13(7). PMID: 29979736    Free PMC article.
Genomic Testing in the Management of Early-Stage Breast Cancer.
Sima Ehsani, Kari Braun Wisinski.
J Clin Outcomes Manag, 2017 May 01; 24(5). PMID: 30158821    Free PMC article.
Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer.
Richard Buus, Belinda Yeo, +7 authors, Mitch Dowsett.
Breast Cancer Res, 2018 Sep 06; 20(1). PMID: 30180877    Free PMC article.
Predictive markers of endocrine response in breast cancer.
Duniya Mosly, Arran Turnbull, +2 authors, Simon Langdon.
World J Exp Med, 2018 Sep 08; 8(1). PMID: 30191138    Free PMC article.
An Update on Breast Cancer Multigene Prognostic Tests-Emergent Clinical Biomarkers.
André Filipe Vieira, Fernando Schmitt.
Front Med (Lausanne), 2018 Sep 21; 5. PMID: 30234119    Free PMC article.
Review.
Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers.
Wenyong Tan, Ming Yang, +2 authors, Weixi Shen.
Cancer Manag Res, 2018 Oct 24; 10. PMID: 30349367    Free PMC article.
Review.
Update Breast Cancer 2018 (Part 3) - Genomics, Individualized Medicine and Immune Therapies - in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer.
Achim Wöckel, Michael P Lux, +17 authors, Hans-Christian Kolberg.
Geburtshilfe Frauenheilkd, 2018 Dec 01; 78(11). PMID: 30498278    Free PMC article.
Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery?
Toralf Reimer, Jutta Engel, +3 authors, Oreste David Gentilini.
Breast Care (Basel), 2018 Dec 01; 13(5). PMID: 30498416    Free PMC article.
Review.
Panoptic View of Prognostic Models for Personalized Breast Cancer Management.
Geetanjali Saini, Karuna Mittal, +3 authors, Ritu Aneja.
Cancers (Basel), 2019 Sep 11; 11(9). PMID: 31500225    Free PMC article.
Review.
Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer.
Tanja Ovcaricek, Iztok Takac, Erika Matos.
Radiol Oncol, 2019 Sep 26; 53(3). PMID: 31553709    Free PMC article.
Review.
Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer.
Ben P Haynes, Ophira Ginsburg, +19 authors, Mitch Dowsett.
NPJ Breast Cancer, 2019 Nov 23; 5. PMID: 31754627    Free PMC article.
Prognosis and endocrine therapy selection for patients with low hormone receptor-positive breast cancer following neoadjuvant chemotherapy: A retrospective study of 570 patients in China.
Yuqin Ding, Kaijing Ding, +6 authors, Xiaowen Ding.
Oncol Lett, 2019 Dec 07; 18(6). PMID: 31807179    Free PMC article.
The impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues.
Michal Marczyk, Chunxiao Fu, +7 authors, W Fraser Symmans.
BMC Cancer, 2019 Dec 07; 19(1). PMID: 31805884    Free PMC article.
Clinical Validation of BCT Scores With Prognostic Factors in Hormone Receptor-positive, HER2-negative Early Breast Cancer.
Jeeyeon Lee, Won Hwa Kim, +9 authors, Ho Yong Park.
In Vivo, 2019 Oct 31; 33(6). PMID: 31662548    Free PMC article.
Decision of Adjuvant Systemic Treatment in HR+ HER2- Early Invasive Breast Cancer: Which Biomarkers Could Help?
Marie Alexandre, Aurélie Maran-Gonzalez, +6 authors, Séverine Guiu.
Cancer Manag Res, 2019 Dec 19; 11. PMID: 31849525    Free PMC article.
Review.
OSbrca: A Web Server for Breast Cancer Prognostic Biomarker Investigation With Massive Data From Tens of Cohorts.
Zhongyi Yan, Qiang Wang, +8 authors, Xiangqian Guo.
Front Oncol, 2020 Jan 11; 9. PMID: 31921624    Free PMC article.
UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer.
Yu-Jin Kim, Gyunghwa Lee, +4 authors, Young Kee Shin.
Front Oncol, 2020 Feb 11; 9. PMID: 32039034    Free PMC article.
Evaluation of the 12-Gene Molecular Score and the 21-Gene Recurrence Score as Predictors of Response to Neo-adjuvant Chemotherapy in Estrogen Receptor-Positive, HER2-Negative Breast Cancer.
Hatem Soliman, Susanne Wagner, +9 authors, William Gradishar.
Ann Surg Oncol, 2020 Jan 08; 27(3). PMID: 31907749    Free PMC article.
Indications for prognostic gene expression profiling in early breast cancer.
Erin F Cobain, Daniel F Hayes.
Curr Treat Options Oncol, 2015 May 02; 16(5). PMID: 25929335
Review.
Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series.
Johan Vallon-Christersson, Jari Häkkinen, +12 authors, Johan Staaf.
Sci Rep, 2019 Aug 23; 9(1). PMID: 31434940    Free PMC article.
Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic Stage.
Jieun Koh, Min Jung Kim.
Korean J Radiol, 2019 Jan 11; 20(1). PMID: 30627023    Free PMC article.
Clinical validation of an immunohistochemistry-based CanAssist-Breast test for distant recurrence prediction in hormone receptor-positive breast cancer patients.
Manjiri M Bakre, Charusheila Ramkumar, +10 authors, Mark D Pegram.
Cancer Med, 2019 Mar 09; 8(4). PMID: 30848103    Free PMC article.
Avoiding over- and undertreatment in patients with resected node-positive breast cancer with the use of gene expression signatures: are we there yet?
A Matikas, T Foukakis, S Swain, J Bergh.
Ann Oncol, 2019 May 28; 30(7). PMID: 31131397    Free PMC article.
Review.
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
Marina Bacci, Nicla Lorito, +17 authors, Andrea Morandi.
Cell Rep, 2019 Jul 04; 28(1). PMID: 31269432    Free PMC article.
The therapeutic response of ER+/HER2- breast cancers differs according to the molecular Basal or Luminal subtype.
François Bertucci, Pascal Finetti, Anthony Goncalves, Daniel Birnbaum.
NPJ Breast Cancer, 2020 Mar 21; 6. PMID: 32195331    Free PMC article.
Change in therapeutic management after the EndoPredict assay in a prospective decision impact study of Mexican premenopausal breast cancer patients.
Cynthia Villarreal-Garza, Edna Anakarenn Lopez-Martinez, +9 authors, Veronica Bautista-Piña.
PLoS One, 2020 Mar 12; 15(3). PMID: 32160201    Free PMC article.
Decision-making of Adjuvant Chemotherapy for Breast Cancer Patients with Discordant Risk Classifications between Clinical-Pathological Factors and 21-gene Recurrence Score.
Weiqi Gao, Lin Lin, +2 authors, Kunwei Shen.
J Cancer, 2020 Mar 24; 11(9). PMID: 32201521    Free PMC article.
Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer.
Steven A Buechler, Kathryn P Gray, +7 authors, Meredith M Regan.
JNCI Cancer Spectr, 2020 Apr 28; 3(4). PMID: 32337480    Free PMC article.
A census of pathway maps in cancer systems biology.
Brent M Kuenzi, Trey Ideker.
Nat Rev Cancer, 2020 Feb 19; 20(4). PMID: 32066900    Free PMC article.
Review.
Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review.
David Krug, René Baumann, +12 authors, Rolf Sauer.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398980    Free PMC article.
Review.
Clinically high-risk breast cancer displays markedly discordant molecular risk predictions between the MammaPrint and EndoPredict tests.
Stephan Wenzel Jahn, Andreas Bösl, +8 authors, Farid Moinfar.
Br J Cancer, 2020 Apr 28; 122(12). PMID: 32336753    Free PMC article.
EndoPredict® in early hormone receptor-positive, HER2-negative breast cancer.
K Almstedt, S Mendoza, +9 authors, M Schmidt.
Breast Cancer Res Treat, 2020 May 22; 182(1). PMID: 32436145    Free PMC article.
Multi-Gene Prognostic Signatures and Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in ER-positive, HER2-negative Breast Cancer Patients.
Claudia Mazo, Stephen Barron, Catherine Mooney, William M Gallagher.
Cancers (Basel), 2020 May 07; 12(5). PMID: 32369904    Free PMC article.
Distribution of the 21-Gene Breast Recurrence Score in Patients with Primary Breast Cancer in Germany.
Vincent P Walter, Florin-Andrei Taran, +6 authors, Andreas Daniel Hartkopf.
Geburtshilfe Frauenheilkd, 2020 Jun 23; 80(6). PMID: 32565552    Free PMC article.
Comparison of Variable Selection Methods for Time-to-Event Data in High-Dimensional Settings.
Julia Gilhodes, Florence Dalenc, +4 authors, Thomas Filleron.
Comput Math Methods Med, 2020 Jul 17; 2020. PMID: 32670394    Free PMC article.
The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.
Sophie Gordon-Craig, Ruth M Parks, Kwok-Leung Cheung.
Oncol Ther, 2020 Jul 24; 8(2). PMID: 32700048    Free PMC article.
Review.
Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results.
Aurelia Noske, Sophie-Isabelle Anders, +6 authors, Evelyn Klein.
Breast, 2019 Dec 02; 49. PMID: 31786414    Free PMC article.
Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2-14).
Frédérique Penault-Llorca, Fabrice Kwiatkowski, +18 authors, Suzette Delaloge.
Breast, 2019 Dec 04; 49. PMID: 31790959    Free PMC article.
Mining the prognostic significance of the GINS2 gene in human breast cancer using bioinformatics analysis.
Shibo Yu, Lizhe Zhu, +5 authors, Yu Ren.
Oncol Lett, 2020 Jul 30; 20(2). PMID: 32724372    Free PMC article.
Overview of Breast Cancer and Implications of Overtreatment of Early-Stage Breast Cancer: An Indian Perspective.
Gouri Shankar Bhattacharyya, Dinesh C Doval, +3 authors, S P Somashekhar.
JCO Glob Oncol, 2020 Jun 09; 6. PMID: 32511068    Free PMC article.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.
In Sil Choi, Jiwoong Jung, +5 authors, Ki-Tae Hwang.
Cancers (Basel), 2020 Jul 12; 12(7). PMID: 32650374    Free PMC article.
SETER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer.
Bruno V Sinn, Chunxiao Fu, +23 authors, W Fraser Symmans.
NPJ Breast Cancer, 2019 Jun 25; 5. PMID: 31231679    Free PMC article.
Gene signature-based prediction of triple-negative breast cancer patient response to Neoadjuvant chemotherapy.
Yanding Zhao, Evelien Schaafsma, Chao Cheng.
Cancer Med, 2020 Jul 22; 9(17). PMID: 32692484    Free PMC article.
Predicting Expected Absolute Chemotherapy Treatment Benefit in Women With Early-Stage Breast Cancer Using EndoPredict, an Integrated 12-Gene Clinicomolecular Assay.
Hatem Soliman, Darl D Flake, +10 authors, William Gradishar.
JCO Precis Oncol, 2020 Sep 12; 3. PMID: 32914026    Free PMC article.
HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.
Mikheil Gogiashvili, Jessica Nowacki, +3 authors, Karolina Edlund.
Metabolites, 2019 Jan 27; 9(2). PMID: 30678289    Free PMC article.
Review.
Profiling of Invasive Breast Carcinoma Circulating Tumour Cells-Are We Ready for the 'Liquid' Revolution?
Marcin Braun, Aleksandra Markiewicz, +2 authors, Hanna Romańska.
Cancers (Basel), 2019 Jan 30; 11(2). PMID: 30691008    Free PMC article.
Review.
Big Data Approaches for Modeling Response and Resistance to Cancer Drugs.
Peng Jiang, William R Sellers, X Shirley Liu.
Annu Rev Biomed Data Sci, 2019 Jul 26; 1. PMID: 31342013    Free PMC article.
Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.
Ana Tablante Nunes, Deborah E Collyar, Lyndsay N Harris.
JNCI Cancer Spectr, 2017 Dec 11; 1(1). PMID: 31360834    Free PMC article.
Review.
Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer.
Mi Jeong Kwon, Jeong Eon Lee, +12 authors, Young Kee Shin.
Front Oncol, 2019 Aug 14; 9. PMID: 31404265    Free PMC article.
Neoadjuvant endocrine therapy: A potential strategy for ER-positive breast cancer.
Li-Tong Yao, Mo-Zhi Wang, +5 authors, Ying-Ying Xu.
World J Clin Cases, 2019 Aug 20; 7(15). PMID: 31423426    Free PMC article.
Review.
Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer.
Dingxie Liu, Yong Wu.
Cancer Commun (Lond), 2020 Aug 22; 40(9). PMID: 32822101    Free PMC article.
Genomic Signatures in Luminal Breast Cancer.
Julian Puppe, Tabea Seifert, +3 authors, Wolfram Malter.
Breast Care (Basel), 2020 Sep 29; 15(4). PMID: 32982645    Free PMC article.
Review.
Individualized Chemotherapy Benefit Prediction by EndoPredict in Patients With Early Breast Cancer in an Indian Cohort.
S P Somashekhar, Shabber Zaveri, +4 authors, Charu Bahl.
JCO Glob Oncol, 2020 Sep 09; 6. PMID: 32897733    Free PMC article.
Do we still need breast cancer screening in the era of targeted therapies and precision medicine?
Rubina Manuela Trimboli, Paolo Giorgi Rossi, +4 authors, Francesco Sardanelli.
Insights Imaging, 2020 Sep 26; 11(1). PMID: 32975658    Free PMC article.
Review.
Assessment of tumour proliferation by use of the mitotic activity index, and Ki67 and phosphohistone H3 expression, in early-stage luminal breast cancer.
Julia E C van Steenhoven, Anne Kuijer, +4 authors, Paul J van Diest.
Histopathology, 2020 Jun 20; 77(4). PMID: 32557844    Free PMC article.
A Novel Prognostic Scoring System Integrating Gene Expressions and Clinicopathological Characteristics to Predict Very Early Relapse in Node-Negative Estrogen Receptor-Positive/HER2-Negative Breast Cancer.
Caijin Lin, Jiayi Wu, +8 authors, Li Zhu.
Front Oncol, 2020 Oct 13; 10. PMID: 33042787    Free PMC article.
Beyond Chemotherapies: Recent Strategies in Breast Cancer Treatment.
Arthur Foulon, Pierrick Theret, Lise Rodat-Despoix, Philippe Kischel.
Cancers (Basel), 2020 Sep 20; 12(9). PMID: 32947780    Free PMC article.
Review.
First prospective outcome data for the second-generation multigene test Endopredict in ER-positive/HER2-negative breast cancer.
Johannes Ettl, Sophie-Isabelle Anders, +5 authors, Marion Kiechle.
Arch Gynecol Obstet, 2020 Sep 10; 302(6). PMID: 32902674    Free PMC article.
Prognostic Significance of Interferon-γ and Its Signaling Pathway in Early Breast Cancer Depends on the Molecular Subtypes.
Anne-Sophie Heimes, Franziska Härtner, +10 authors, Marcus Schmidt.
Int J Mol Sci, 2020 Oct 03; 21(19). PMID: 33003293    Free PMC article.
Comparison of breast cancer prognostic tests CanAssist Breast and Oncotype DX.
Aditya K Sengupta, Aparna Gunda, +4 authors, Manjiri M Bakre.
Cancer Med, 2020 Oct 08; 9(21). PMID: 33027559    Free PMC article.
Endocrine Therapy in Premenopausal Hormone Receptor-Positive Breast Cancer.
Amye J Tevaarwerk, Kari B Wisinski, Ruth M O'Regan.
J Oncol Pract, 2016 Nov 20; 12(11). PMID: 27858538    Free PMC article.
Review.
Reducing chemotherapy use in clinically high-risk, genomically low-risk pN0 and pN1 early breast cancer patients: five-year data from the prospective, randomised phase 3 West German Study Group (WSG) PlanB trial.
Ulrike Nitz, Oleg Gluz, +18 authors, Nadia Harbeck.
Breast Cancer Res Treat, 2017 Jul 01; 165(3). PMID: 28664507    Free PMC article.
SEOM clinical guidelines in early stage breast cancer (2018).
F Ayala de la Peña, R Andrés, +7 authors, E Ciruelos.
Clin Transl Oncol, 2018 Nov 18; 21(1). PMID: 30443868    Free PMC article.
Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study.
Salvatore Pece, Davide Disalvatore, +8 authors, Pier Paolo Di Fiore.
EBioMedicine, 2019 Mar 09; 42. PMID: 30846393    Free PMC article.
Efficacy of an RNA-based multigene assay with core needle biopsy samples for risk evaluation in hormone-positive early breast cancer.
Jeeyeon Lee, Eun Hye Lee, +9 authors, Jin Hyang Jung.
BMC Cancer, 2019 Apr 27; 19(1). PMID: 31023265    Free PMC article.
Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.
Ivana Sestak, Miguel Martín, +12 authors, Michael Gnant.
Breast Cancer Res Treat, 2019 May 02; 176(2). PMID: 31041683    Free PMC article.
Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases.
Mariana Bustamante Eduardo, Vlad Popovici, +5 authors, Rolf Jaggi.
BMC Cancer, 2019 Jun 09; 19(1). PMID: 31174485    Free PMC article.
A multiple breast cancer stem cell model to predict recurrence of T1-3, N0 breast cancer.
Yan Qiu, Liya Wang, +8 authors, Hong Bu.
BMC Cancer, 2019 Jul 26; 19(1). PMID: 31340763    Free PMC article.
Genomics applied to the treatment of breast cancer.
Diaddin Hamdan, Thi Thuy Nguyen, +3 authors, Guilhem Bousquet.
Oncotarget, 2019 Aug 16; 10(46). PMID: 31413819    Free PMC article.
Review.
Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence.
Kamal Pandey, Nahee Park, +7 authors, Yong Wha Moon.
Cancers (Basel), 2020 Dec 03; 12(12). PMID: 33260316    Free PMC article.
The implementation of a commercially available multi-gene profile test for breast cancer characterization in a department of pathology: what have we learned from the first 100 cases?
Cristina Pelliccia, Emanuele Caselli, +3 authors, Angelo Sidoni.
Virchows Arch, 2021 Jan 07;. PMID: 33404851
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.
Amy E McCart Reed, Lauren Kalinowski, Peter T Simpson, Sunil R Lakhani.
Breast Cancer Res, 2021 Jan 09; 23(1). PMID: 33413533    Free PMC article.
Review.
A novel immune prognostic index for stratification of high-risk patients with early breast cancer.
Hannah Lee, Mi Jeong Kwon, +3 authors, Young Kee Shin.
Sci Rep, 2021 Jan 10; 11(1). PMID: 33420250    Free PMC article.
Magee Equations™ and response to neoadjuvant chemotherapy in ER+/HER2-negative breast cancer: a multi-institutional study.
Rohit Bhargava, Nicole N Esposito, +11 authors, David J Dabbs.
Mod Pathol, 2020 Jul 15; 34(1). PMID: 32661297
A clinical validation study of MammaPrint in hormone receptor-positive breast cancer from the Austrian Breast and Colorectal Cancer Study Group 8 (ABCSG-8) biomarker cohort.
P Dubsky, L Van't Veer, +13 authors, M Filipits.
ESMO Open, 2021 Jan 06; 6(1). PMID: 33399073    Free PMC article.
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer.
Hsing-Ju Wu, Pei-Yi Chu.
Int J Mol Sci, 2021 Jan 14; 22(2). PMID: 33435254    Free PMC article.
Review.

;. PMID: 33574292
Decision theory for precision therapy of breast cancer.
Michael Kenn, Dan Cacsire Castillo-Tong, +4 authors, Wolfgang Schreiner.
Sci Rep, 2021 Feb 21; 11(1). PMID: 33608588