Journal Article
. 2011 Aug; 12(9):852-61.
doi: 10.1016/S1470-2045(11)70214-5.

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

Karen A Gelmon 1 Marc Tischkowitz  Helen Mackay  Kenneth Swenerton  André Robidoux  Katia Tonkin  Hal Hirte  David Huntsman  Mark Clemons  Blake Gilks  Rinat Yerushalmi  Euan Macpherson  James Carmichael  Amit Oza  
  • PMID: 21862407
  •     430 citations


Background: Olaparib (AZD2281) is a small-molecule, potent oral poly(ADP-ribose) polymerase (PARP) inhibitor. We aimed to assess the safety and tolerability of this drug in patients without BRCA1 or BRCA2 mutations with advanced triple-negative breast cancer or high-grade serous and/or undifferentiated ovarian cancer.

Methods: In this phase 2, multicentre, open-label, non-randomised study, women with advanced high-grade serous and/or undifferentiated ovarian carcinoma or triple-negative breast cancer were enrolled and received olaparib 400 mg twice a day. Patients were stratified according to whether they had a BRCA1 or BRCA2 mutation or not. The primary endpoint was objective response rate by Response Evaluation Criteria In Solid Tumors (RECIST). All patients who received treatment were included in the analysis of toxic effects, and patients who had measurable lesions at baseline were included in the primary efficacy analysis. This trial is registered at, number NCT00679783.

Findings: 91 patients were enrolled (65 with ovarian cancer and 26 breast cancer) and 90 were treated between July 8, 2008, and Sept 24, 2009. In the ovarian cancer cohorts, 64 patients received treatment. 63 patients had target lesions and therefore were evaluable for objective response as per RECIST. In these patients, confirmed objective responses were seen in seven (41%; 95% CI 22-64) of 17 patients with BRCA1 or BRCA2 mutations and 11 (24%; 14-38) of 46 without mutations. No confirmed objective responses were reported in patients with breast cancer. The most common adverse events were fatigue (45 [70%] of patients with ovarian cancer, 13 [50%] of patients with breast cancer), nausea (42 [66%] and 16 [62%]), vomiting (25 [39%] and nine [35%]), and decreased appetite (23 [36%] and seven [27%]).

Interpretation: Our study suggests that olaparib is a promising treatment for women with ovarian cancer and further assessment of the drug in clinical trials is needed.

Funding: AstraZeneca.

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Lancet Oncol, 2014 Sep 15; 15(11). PMID: 25218906    Free PMC article.
Highly Cited.
MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer.
Yan Sun, Limei Hu, +12 authors, Wei Zhang.
J Pathol, 2014 Sep 18; 235(1). PMID: 25230372    Free PMC article.
The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer.
J L Meisel, D M Hyman, +12 authors, D R Spriggs.
Ann Oncol, 2014 Oct 05; 25(12). PMID: 25281711    Free PMC article.
An update on PARP inhibitors--moving to the adjuvant setting.
Amir Sonnenblick, Evandro de Azambuja, Hatem A Azim, Martine Piccart.
Nat Rev Clin Oncol, 2014 Oct 08; 12(1). PMID: 25286972
Highly Cited. Review.
Treatment options in recurrent ovarian cancer: latest evidence and clinical potential.
Daniela Luvero, Andrea Milani, Jonathan A Ledermann.
Ther Adv Med Oncol, 2014 Oct 25; 6(5). PMID: 25342990    Free PMC article.
A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis.
Kim A Reiss, Joseph M Herman, +13 authors, Nilofer S Azad.
Clin Cancer Res, 2014 Oct 31; 21(1). PMID: 25355929    Free PMC article.
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation.
Bella Kaufman, Ronnie Shapira-Frommer, +13 authors, Susan M Domchek.
J Clin Oncol, 2014 Nov 05; 33(3). PMID: 25366685    Free PMC article.
Highly Cited.
Molecular Heterogeneity of Triple Negative Breast Cancer.
Vandana G Abramson, Ingrid A Mayer.
Curr Breast Cancer Rep, 2014 Nov 25; 6(3). PMID: 25419441    Free PMC article.
Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.
Zongxiang Zhou, Manishha Patel, +6 authors, Jun Liu.
BMC Cancer, 2014 Dec 17; 14. PMID: 25495526    Free PMC article.
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.
Daniel Morgensztern, Meghan J Campo, +21 authors, Ramaswamy Govindan.
J Thorac Oncol, 2014 Dec 24; 10(1 Suppl 1). PMID: 25535693    Free PMC article.
Olaparib: first global approval.
Emma D Deeks.
Drugs, 2015 Jan 27; 75(2). PMID: 25616434
Surgery in the era of the 'omics revolution.
A D Beggs, M P Dilworth.
Br J Surg, 2015 Jan 30; 102(2). PMID: 25627134    Free PMC article.
A unique subset of epithelial ovarian cancers with platinum sensitivity and PARP inhibitor resistance.
Raphael Ceccaldi, Kevin W O'Connor, +4 authors, Panagiotis A Konstantinopoulos.
Cancer Res, 2015 Jan 31; 75(4). PMID: 25634215    Free PMC article.
Triple-negative breast cancer: new perspectives for targeted therapies.
Federica Tomao, Anselmo Papa, +6 authors, Silverio Tomao.
Onco Targets Ther, 2015 Feb 06; 8. PMID: 25653541    Free PMC article.
Highly Cited. Review.
New perspectives on targeted therapy in ovarian cancer.
Jermaine Ig Coward, Kathryn Middleton, Felicity Murphy.
Int J Womens Health, 2015 Feb 14; 7. PMID: 25678824    Free PMC article.
NF-κB signaling mediates acquired resistance after PARP inhibition.
Yuko Nakagawa, Anna S Sedukhina, +9 authors, Ko Sato.
Oncotarget, 2015 Feb 18; 6(6). PMID: 25686825    Free PMC article.
An update on PARP inhibitors for the treatment of cancer.
Sarah Benafif, Marcia Hall.
Onco Targets Ther, 2015 Mar 10; 8. PMID: 25750544    Free PMC article.
Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.
Clare L Scott, Elizabeth M Swisher, Scott H Kaufmann.
J Clin Oncol, 2015 Mar 18; 33(12). PMID: 25779564    Free PMC article.
Highly Cited. Review.
A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An NRG Oncology/Gynecologic Oncology Group study.
Robert L Coleman, Michael W Sill, +8 authors, Elizabeth M Swisher.
Gynecol Oncol, 2015 Mar 31; 137(3). PMID: 25818403    Free PMC article.
Highly Cited.
Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.
Olga Karginova, Marni B Siegel, +15 authors, Carey K Anders.
Mol Cancer Ther, 2015 Apr 01; 14(4). PMID: 25824335    Free PMC article.
Systemic treatment approaches in her2-negative advanced breast cancer-guidance on the guidelines.
A A Joy, M Ghosh, R Fernandes, M J Clemons.
Curr Oncol, 2015 Apr 08; 22(Suppl 1). PMID: 25848337    Free PMC article.
Regulators of homologous recombination repair as novel targets for cancer treatment.
Małgorzata Krajewska, Rudolf S N Fehrmann, Elisabeth G E de Vries, Marcel A T M van Vugt.
Front Genet, 2015 Apr 09; 6. PMID: 25852742    Free PMC article.
Therapies for triple negative breast cancer.
Eleni Andreopoulou, Sarah J Schweber, Joseph A Sparano, Hayley M McDaid.
Expert Opin Pharmacother, 2015 Apr 18; 16(7). PMID: 25881743    Free PMC article.
A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population.
Moria H Belanger, Lena Dolman, +5 authors, Patricia N Tonin.
J Ovarian Res, 2015 Apr 18; 8. PMID: 25884701    Free PMC article.
Exploiting replicative stress to treat cancer.
Matthias Dobbelstein, Claus Storgaard Sørensen.
Nat Rev Drug Discov, 2015 May 09; 14(6). PMID: 25953507
Highly Cited. Review.
Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft.
Gretchen Glaser, S John Weroha, +4 authors, Paul Haluska.
PLoS One, 2015 May 12; 10(5). PMID: 25962155    Free PMC article.
Single cell resolution in vivo imaging of DNA damage following PARP inhibition.
Katherine S Yang, Rainer H Kohler, +2 authors, Ralph Weissleder.
Sci Rep, 2015 May 20; 5. PMID: 25984718    Free PMC article.
Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Guoyan Liu, Da Yang, +17 authors, Wei Zhang.
J Natl Cancer Inst, 2015 May 23; 107(7). PMID: 25995442    Free PMC article.
BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.
Tesa M Severson, Justine Peeters, +16 authors, Sabine Linn.
Mol Oncol, 2015 May 26; 9(8). PMID: 26004083    Free PMC article.
Integrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas.
Yuriko Uehara, Katsutoshi Oda, +20 authors, Hiroyuki Aburatani.
PLoS One, 2015 Jun 05; 10(6). PMID: 26043110    Free PMC article.
Deciphering the BRCA1 Tumor Suppressor Network.
Qinqin Jiang, Roger A Greenberg.
J Biol Chem, 2015 Jun 07; 290(29). PMID: 26048987    Free PMC article.
CECs and IL-8 Have Prognostic and Predictive Utility in Patients with Recurrent Platinum-Sensitive Ovarian Cancer: Biomarker Correlates from the Randomized Phase-2 Trial of Olaparib and Cediranib Compared with Olaparib in Recurrent Platinum-Sensitive Ovarian Cancer.
Jung-Min Lee, Jane B Trepel, +12 authors, Elise C Kohn.
Front Oncol, 2015 Jun 18; 5. PMID: 26082895    Free PMC article.
Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy.
Hongying Sui, Caixia Shi, Zhipeng Yan, Hucheng Li.
Drug Des Devel Ther, 2015 Jul 01; 9. PMID: 26124641    Free PMC article.
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
Mohamed A Ghonim, Kusma Pyakurel, +12 authors, A Hamid Boulares.
J Transl Med, 2015 Jul 15; 13. PMID: 26169874    Free PMC article.
Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.
Ruud van der Noll, Serena Marchetti, +6 authors, Jan H M Schellens.
Br J Cancer, 2015 Jul 17; 113(3). PMID: 26180927    Free PMC article.
Profile of veliparib and its potential in the treatment of solid tumors.
Lars M Wagner.
Onco Targets Ther, 2015 Aug 08; 8. PMID: 26251615    Free PMC article.
PARP inhibitors in the management of breast cancer: current data and future prospects.
Luca Livraghi, Judy E Garber.
BMC Med, 2015 Aug 14; 13. PMID: 26268938    Free PMC article.
Highly Cited. Review.
Olaparib in the management of ovarian cancer.
Kristin Bixel, John L Hays.
Pharmgenomics Pers Med, 2015 Aug 27; 8. PMID: 26309417    Free PMC article.
Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients.
See-Hyoung Park, Sang Jae Noh, +9 authors, Kyu Yun Jang.
Transl Oncol, 2015 Aug 28; 8(4). PMID: 26310369    Free PMC article.
Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.
Maud Marques, Marie-Claude Beauchamp, +7 authors, Michael Witcher.
BMC Med, 2015 Sep 12; 13. PMID: 26354718    Free PMC article.
Nivolumab and Olaparib.
Dominic A Solimando, J Aubrey Waddell.
Hosp Pharm, 2015 Sep 26; 50(5). PMID: 26405320    Free PMC article.
Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
E Hedström, C Pederiva, +4 authors, M Farnebo.
Cell Death Dis, 2015 Oct 02; 6. PMID: 26426684    Free PMC article.
Delivering on the promise: poly ADP ribose polymerase inhibition as targeted anticancer therapy.
Geraldine OʼSullivan Coyne, Alice Chen, Shivaani Kummar.
Curr Opin Oncol, 2015 Oct 09; 27(6). PMID: 26447876    Free PMC article.
Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer.
Panagiotis A Konstantinopoulos, Raphael Ceccaldi, Geoffrey I Shapiro, Alan D D'Andrea.
Cancer Discov, 2015 Oct 16; 5(11). PMID: 26463832    Free PMC article.
Highly Cited. Review.
Targeted Therapies in Triple-Negative Breast Cancer.
Frederik Marmé, Andreas Schneeweiss.
Breast Care (Basel), 2015 Nov 12; 10(3). PMID: 26557820    Free PMC article.
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.
Denis Velic, Anthony M Couturier, +4 authors, Jean-Yves Masson.
Biomolecules, 2015 Nov 28; 5(4). PMID: 26610585    Free PMC article.
Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease.
Hubert Fleury, Laudine Communal, +6 authors, Anne-Marie Mes-Masson.
Genes Cancer, 2015 Dec 02; 6(9-10). PMID: 26622941    Free PMC article.
PARP inhibitors in ovarian cancer: Clinical evidence for informed treatment decisions.
Jonathan A Ledermann, Fatima El-Khouly.
Br J Cancer, 2015 Dec 17; 113 Suppl 1. PMID: 26669450    Free PMC article.
The development of PARP inhibitors in ovarian cancer: from bench to bedside.
Yvette Drew.
Br J Cancer, 2015 Dec 17; 113 Suppl 1. PMID: 26669452    Free PMC article.
The fate of chemoresistance in triple negative breast cancer (TNBC).
Elma A O'Reilly, Luke Gubbins, +8 authors, Amanda McCann.
BBA Clin, 2015 Dec 18; 3. PMID: 26676166    Free PMC article.
Highly Cited. Review.
Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.
Susan M Domchek, Carol Aghajanian, +13 authors, Bella Kaufman.
Gynecol Oncol, 2016 Jan 03; 140(2). PMID: 26723501    Free PMC article.
Highly Cited.
Post-mortem testing; germline BRCA1/2 variant detection using archival FFPE non-tumor tissue. A new paradigm in genetic counseling.
Annabeth Høgh Petersen, Mads Malik Aagaard, +3 authors, Anders Bojesen.
Eur J Hum Genet, 2016 Jan 07; 24(8). PMID: 26733283    Free PMC article.
A Phase 2, Single Arm Study of Iniparib in Patients With BRCA1 or BRCA2 Associated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Katherine M Bell-McGuinn, Jason A Konner, +6 authors, Carol Aghajanian.
Int J Gynecol Cancer, 2016 Jan 09; 26(2). PMID: 26745694    Free PMC article.
BRCAness revisited.
Christopher J Lord, Alan Ashworth.
Nat Rev Cancer, 2016 Jan 19; 16(2). PMID: 26775620
Highly Cited. Review.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Yi Du, Hirohito Yamaguchi, +22 authors, Mien-Chie Hung.
Nat Med, 2016 Jan 19; 22(2). PMID: 26779812    Free PMC article.
Highly Cited.
[Effect and Mechanism of Radiosensitization of Poly (ADP-Ribose) Polymerase Inhibitor n Lewis Cells and Xenografts].
Wei Wang, Bixia Duan, Li Zeng.
Zhongguo Fei Ai Za Zhi, 2016 Jan 26; 19(1). PMID: 26805733    Free PMC article.
DNA repair targeted therapy: The past or future of cancer treatment?
Navnath S Gavande, Pamela S VanderVere-Carozza, +4 authors, John J Turchi.
Pharmacol Ther, 2016 Feb 21; 160. PMID: 26896565    Free PMC article.
Highly Cited. Review.
PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives.
J Sehouli, E I Braicu, R Chekerov.
Geburtshilfe Frauenheilkd, 2016 Mar 05; 76(2). PMID: 26941449    Free PMC article.
What Is the Place of PARP Inhibitors in Ovarian Cancer Treatment?
Joyce F Liu, Ursula A Matulonis.
Curr Oncol Rep, 2016 Mar 18; 18(5). PMID: 26984416
Role of Biomarkers in the Development of PARP Inhibitors.
Bratati Ganguly, Sonia C Dolfi, +2 authors, Kim M Hirshfield.
Biomark Cancer, 2016 Mar 22; 8(Suppl 1). PMID: 26997874    Free PMC article.
Emerging therapeutic targets in metastatic progression: A focus on breast cancer.
Zhuo Li, Yibin Kang.
Pharmacol Ther, 2016 Mar 24; 161. PMID: 27000769    Free PMC article.
Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.
Yvette Drew, Jonathan Ledermann, +14 authors, Ruth Plummer.
Br J Cancer, 2016 Mar 24; 114(7). PMID: 27002934    Free PMC article.
Highly Cited.
Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know.
Joyce Liu, Shannon N Westin.
Gynecol Oncol, 2016 Mar 27; 141(1). PMID: 27016231    Free PMC article.
PARP inhibitors: the race is on.
Jessica S Brown, Stan B Kaye, Timothy A Yap.
Br J Cancer, 2016 Mar 31; 114(7). PMID: 27022824    Free PMC article.
Highly Cited.
Comparative genomic analysis of primary tumors and metastases in breast cancer.
François Bertucci, Pascal Finetti, +9 authors, Max Chaffanet.
Oncotarget, 2016 Mar 31; 7(19). PMID: 27028851    Free PMC article.
Profile of bevacizumab in the treatment of platinum-resistant ovarian cancer: current perspectives.
E Clair McClung, Robert M Wenham.
Int J Womens Health, 2016 Apr 07; 8. PMID: 27051317    Free PMC article.
[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer.
Christine E Edmonds, Mehran Makvandi, +8 authors, Robert H Mach.
Am J Nucl Med Mol Imaging, 2016 Apr 14; 6(1). PMID: 27069769    Free PMC article.
A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187.
Eric X Chen, Derek J Jonker, +5 authors, Lesley Seymour.
Invest New Drugs, 2016 Apr 15; 34(4). PMID: 27075016
Progress in the treatment of ovarian cancer-lessons from homologous recombination deficiency-the first 10 years.
S B Kaye.
Ann Oncol, 2016 May 04; 27 Suppl 1. PMID: 27141062    Free PMC article.
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2.
Nan Li, Lin Feng, +6 authors, Junjie Chen.
Cell Rep, 2016 May 07; 15(4). PMID: 27149849    Free PMC article.
An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib.
J Mateo, V Moreno, +15 authors, L R Molife.
Target Oncol, 2016 May 14; 11(3). PMID: 27169564
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.
Giampaolo Bianchini, Justin M Balko, +2 authors, Luca Gianni.
Nat Rev Clin Oncol, 2016 Oct 19; 13(11). PMID: 27184417    Free PMC article.
Highly Cited. Review.
Profile of olaparib in the treatment of advanced ovarian cancer.
Dana M Chase, Shreya Patel, Kristin Shields.
Int J Womens Health, 2016 May 18; 8. PMID: 27186080    Free PMC article.
Prognostic value of FDG PET/CT-based metabolic tumor volumes in metastatic triple negative breast cancer patients.
Brett Marinelli, Carina Espinet-Col, +4 authors, Wolfgang A Weber.
Am J Nucl Med Mol Imaging, 2016 May 18; 6(2). PMID: 27186439    Free PMC article.
The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
Yifan Wang, Andrea J Bernhardy, +36 authors, Neil Johnson.
Cancer Res, 2016 May 20; 76(9). PMID: 27197267    Free PMC article.
Highly Cited.
Targeted therapy in ovarian cancer.
Hui Jun Lim, William Ledger.
Womens Health (Lond), 2016 May 25; 12(3). PMID: 27215391    Free PMC article.
Patient Counseling and Management of Symptoms During Olaparib Therapy for Recurrent Ovarian Cancer.
Kathleen N Moore, Bradley J Monk.
Oncologist, 2016 Jun 04; 21(8). PMID: 27256873    Free PMC article.
A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.
Mehran Makvandi, Kuiying Xu, +8 authors, Robert H Mach.
Cancer Res, 2016 Jun 05; 76(15). PMID: 27261505    Free PMC article.
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo.
See-Hyoung Park, Young Min Chung, +3 authors, Mickey C-T Hu.
Oncotarget, 2016 Jun 11; 7(27). PMID: 27283899    Free PMC article.
Triple-negative breast cancer: treatment challenges and solutions.
Joëlle Collignon, Laurence Lousberg, Hélène Schroeder, Guy Jerusalem.
Breast Cancer (Dove Med Press), 2016 Jun 11; 8. PMID: 27284266    Free PMC article.
Highly Cited.
Trial watch - inhibiting PARP enzymes for anticancer therapy.
Antonella Sistigu, Gwenola Manic, Florine Obrist, Ilio Vitale.
Mol Cell Oncol, 2016 Jun 17; 3(2). PMID: 27308587    Free PMC article.
A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.
Philip C Schouten, Gwen M H E Dackus, +4 authors, Sabine C Linn.
Trials, 2016 Jun 22; 17(1). PMID: 27323902    Free PMC article.
Molecular targeted therapy in gynaecologic malignancies: primer for radiologists.
Chong Hyun Suh, Sree H Tirumani, +3 authors, Atul B Shinagare.
Br J Radiol, 2016 Jun 23; 89(1066). PMID: 27331884    Free PMC article.
Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines.
Hubert Fleury, Euridice Carmona, +5 authors, Anne-Marie Mes-Masson.
Oncotarget, 2016 Jul 05; 8(25). PMID: 27374179    Free PMC article.
Safety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours.
Kan Yonemori, Kenji Tamura, +9 authors, Yasuo Takahashi.
Cancer Chemother Pharmacol, 2016 Jul 17; 78(3). PMID: 27422301    Free PMC article.
Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.
Dong Wang, Chengbo Li, +8 authors, Pixu Liu.
Gynecol Oncol, 2016 Jul 19; 142(3). PMID: 27426307    Free PMC article.
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
Rinske Drost, Kiranjit K Dhillon, +26 authors, Jos Jonkers.
J Clin Invest, 2016 Jul 28; 126(8). PMID: 27454287    Free PMC article.
Targeting DNA Replication Stress for Cancer Therapy.
Jun Zhang, Qun Dai, Dongkyoo Park, Xingming Deng.
Genes (Basel), 2016 Aug 23; 7(8). PMID: 27548226    Free PMC article.
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.
Ruoxi Hong, Fei Ma, +6 authors, Binghe Xu.
BMC Cancer, 2016 Sep 11; 16(1). PMID: 27613518    Free PMC article.
In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.
Mariam M AlHilli, Marc A Becker, +15 authors, Paul Haluska.
Gynecol Oncol, 2016 Oct 25; 143(2). PMID: 27614696    Free PMC article.
Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment.
Anselmo Papa, Davide Caruso, +2 authors, Federica Tomao.
J Transl Med, 2016 Sep 17; 14. PMID: 27634150    Free PMC article.
Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine.
Stephen Murata, Catherine Zhang, +3 authors, Eun-Kyoung Breuer.
Biomed Res Int, 2016 Sep 20; 2016. PMID: 27642590    Free PMC article.
Individual and Combined Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predict Shorter Survival of Soft Tissue Sarcoma Patients.
Kyoung Min Kim, Young Jae Moon, +9 authors, Kyu Yun Jang.
PLoS One, 2016 Sep 20; 11(9). PMID: 27643881    Free PMC article.
Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer.
Jung-Min Lee, Cody J Peer, +13 authors, Elise C Kohn.
Clin Cancer Res, 2016 Sep 25; 23(6). PMID: 27663600    Free PMC article.
Efficacy of poly (ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-κB interactions.
Minsu Kwon, Hyejin Jang, Eun Hye Kim, Jong-Lyel Roh.
Cell Cycle, 2016 Oct 18; 15(22). PMID: 27686740    Free PMC article.
Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.
Fan Zhang, Chunyan Ren, +6 authors, Martin J Walsh.
Oncotarget, 2016 Oct 01; 7(44). PMID: 27690302    Free PMC article.
Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition.
Junko Murai, Ying Feng, +4 authors, Yves Pommier.
Oncotarget, 2016 Oct 07; 7(47). PMID: 27708213    Free PMC article.
Highly Cited.
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions.
G E Konecny, R S Kristeleit.
Br J Cancer, 2016 Oct 14; 115(10). PMID: 27736844    Free PMC article.
Highly Cited. Review.
Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.
Tereza Vaclová, Nicholas T Woods, +10 authors, Ana Osorio.
Hum Mol Genet, 2016 Oct 16; 25(24). PMID: 27742776    Free PMC article.
Triple-negative breast cancer: is there a treatment on the horizon?
Hui Yao, Guangchun He, +4 authors, Xiyun Deng.
Oncotarget, 2016 Oct 22; 8(1). PMID: 27765921    Free PMC article.
Highly Cited. Review.
Novel therapeutic strategies for patients with triple-negative breast cancer.
Jun-Fei Zhang, Jia Liu, Yu Wang, Bin Zhang.
Onco Targets Ther, 2016 Nov 02; 9. PMID: 27799799    Free PMC article.
Quality of life during olaparib maintenance therapy in platinum-sensitive relapsed serous ovarian cancer.
Jonathan A Ledermann, Philipp Harter, +14 authors, Ursula Matulonis.
Br J Cancer, 2016 Nov 09; 115(11). PMID: 27824811    Free PMC article.
The rise of genomic profiling in ovarian cancer.
Rebecca A Previs, Anil K Sood, Gordon B Mills, Shannon N Westin.
Expert Rev Mol Diagn, 2016 Nov 10; 16(12). PMID: 27828713    Free PMC article.
PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies.
Loren S Michel, Samantha Dyroff, +12 authors, Delphine L Chen.
Radiology, 2016 Nov 15; 282(2). PMID: 27841728    Free PMC article.
Recent developments and translational aspects in targeted therapy for metastatic breast cancer.
Maximilian Marhold, Rupert Bartsch, Christoph Zielinski.
ESMO Open, 2016 Nov 16; 1(3). PMID: 27843605    Free PMC article.
Sex differences in stroke therapies.
Farida Sohrabji, Min Jung Park, Amanda H Mahnke.
J Neurosci Res, 2016 Nov 22; 95(1-2). PMID: 27870437    Free PMC article.
Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic.
Aniello Cerrato, Francesco Morra, Angela Celetti.
J Exp Clin Cancer Res, 2016 Nov 26; 35(1). PMID: 27884198    Free PMC article.
Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.
Tingting Jiang, Weiwei Shi, +8 authors, Christos Hatzis.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959926    Free PMC article.
Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer.
U A Matulonis, G M Wulf, +20 authors, E Winer.
Ann Oncol, 2016 Dec 21; 28(3). PMID: 27993796    Free PMC article.
Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup: recurrent disease.
M K Wilson, E Pujade-Lauraine, +21 authors, participants of the Fifth Ovarian Cancer Consensus Conference.
Ann Oncol, 2016 Dec 21; 28(4). PMID: 27993805    Free PMC article.
Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models.
Hyoung Kim, Erin George, +7 authors, Fiona Simpkins.
Clin Cancer Res, 2016 Dec 21; 23(12). PMID: 27993965    Free PMC article.
Highly Cited.
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer.
Jiayan Luo, Juan Jin, +5 authors, Xiaoxiang Guan.
Int J Biol Sci, 2016 Dec 21; 12(12). PMID: 27994514    Free PMC article.
Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer.
Paul M Wilkerson, Konstantin J Dedes, +10 authors, Jorge S Reis-Filho.
Oncotarget, 2016 Dec 22; 8(4). PMID: 28002809    Free PMC article.
Chemoresistance and targeted therapies in ovarian and endometrial cancers.
Kevin Brasseur, Nicolas Gévry, Eric Asselin.
Oncotarget, 2016 Dec 23; 8(3). PMID: 28008141    Free PMC article.
Response of BRCA1-mutated gallbladder cancer to olaparib: A case report.
Yuan Xie, Yan Jiang, +9 authors, Hai-Tao Zhao.
World J Gastroenterol, 2016 Dec 29; 22(46). PMID: 28028375    Free PMC article.
"Back to a false normality": new intriguing mechanisms of resistance to PARP inhibitors.
Lorena Incorvaia, Francesc Passiglia, +9 authors, Antonio Russo.
Oncotarget, 2017 Jan 06; 8(14). PMID: 28055979    Free PMC article.
Genetics Consultation Rates Following a Diagnosis of High-Grade Serous Ovarian Carcinoma in the Canadian Province of Ontario.
Jacob McGee, Karen Panabaker, +3 authors, Salimah Z Shariff.
Int J Gynecol Cancer, 2017 Jan 11; 27(3). PMID: 28072594    Free PMC article.
PARP Inhibitors in Reproductive System Cancers: Current Use and Developments.
Geraldine O'Sullivan Coyne, Alice P Chen, Robert Meehan, James H Doroshow.
Drugs, 2017 Jan 13; 77(2). PMID: 28078645    Free PMC article.
Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies.
Alberto Ocana, Atanasio Pandiella.
Oncotarget, 2017 Jan 22; 8(13). PMID: 28108739    Free PMC article.
A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovarian and fallopian tube cancers.
Kim A Reiss, Joseph M Herman, +16 authors, Nilofer S Azad.
Gynecol Oncol, 2017 Jan 23; 144(3). PMID: 28109627    Free PMC article.
Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer.
Marise R Heerma van Voss, Justin D Brilliant, +4 authors, Venu Raman.
Med Oncol, 2017 Feb 01; 34(3). PMID: 28138868    Free PMC article.
PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer.
Wei Song, Lin Tang, +5 authors, Xiaoxiang Guan.
Sci Rep, 2017 Feb 09; 7. PMID: 28176879    Free PMC article.
Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature.
Melissa K Frey, Bhavana Pothuri.
Gynecol Oncol Res Pract, 2017 Mar 03; 4. PMID: 28250960    Free PMC article.
BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer.
Michael J Pishvaian, Andrew V Biankin, +4 authors, Jonathan R Brody.
Br J Cancer, 2017 Mar 16; 116(8). PMID: 28291774    Free PMC article.
PARP inhibitors: Synthetic lethality in the clinic.
Christopher J Lord, Alan Ashworth.
Science, 2017 Mar 18; 355(6330). PMID: 28302823    Free PMC article.
Highly Cited. Review.
Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells.
Joseph T Decker, Eric C Hobson, +5 authors, Lonnie D Shea.
Biotechnol Bioeng, 2017 Mar 23; 114(9). PMID: 28322442    Free PMC article.
Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP.
Takuhei Yokoyama, Elise C Kohn, Ethan Brill, Jung-Min Lee.
Int J Oncol, 2017 Mar 30; 50(4). PMID: 28350129    Free PMC article.
Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens.
Eleni G Christodoulou, Hai Yang, +3 authors, Michael Schroeder.
Oncotarget, 2017 Apr 19; 8(21). PMID: 28415695    Free PMC article.
Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors.
Anna Mária Cseh, Zsolt Fábián, Balázs Sümegi, Luca Scorrano.
Oncotarget, 2017 Apr 22; 8(30). PMID: 28430591    Free PMC article.
Baseline clinical predictors of antitumor response to the PARP inhibitor olaparib in germline BRCA1/2 mutated patients with advanced ovarian cancer.
Saeed Rafii, Charlie Gourley, +14 authors, Timothy A Yap.
Oncotarget, 2017 Apr 30; 8(29). PMID: 28454085    Free PMC article.
Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.
Moito Iijima, Kouji Banno, +11 authors, Daisuke Aoki.
Oncol Lett, 2017 Apr 30; 13(3). PMID: 28454214    Free PMC article.
Emerging therapies for breast cancer.
Xichun Hu, Wei Huang, Minhao Fan.
J Hematol Oncol, 2017 Apr 30; 10(1). PMID: 28454587    Free PMC article.
Systemic Treatment Strategies for Patients with Hereditary Breast Cancer Syndromes.
Amanda Parkes, Banu K Arun, Jennifer K Litton.
Oncologist, 2017 May 05; 22(6). PMID: 28469042    Free PMC article.
PARP inhibitors in ovarian cancer: evidence, experience and clinical potential.
Tarra Evans, Ursula Matulonis.
Ther Adv Med Oncol, 2017 May 12; 9(4). PMID: 28491146    Free PMC article.
Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.
Anne L van de Ven, Shifalika Tangutoori, +8 authors, Srinivas Sridhar.
Mol Cancer Ther, 2017 May 14; 16(7). PMID: 28500233    Free PMC article.
PARP Inhibitors in Prostate Cancer.
Praveen Ramakrishnan Geethakumari, Matthew J Schiewer, Karen E Knudsen, Wm Kevin Kelly.
Curr Treat Options Oncol, 2017 May 26; 18(6). PMID: 28540598
Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access.
Hannah Shipman, Samantha Flynn, +5 authors, Nicholas J Hulbert-Williams.
J Genet Couns, 2017 May 26; 26(6). PMID: 28540621
Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing.
Qianying Zhao, Jiaxin Yang, +4 authors, BGI Group.
J Gynecol Oncol, 2017 May 26; 28(4). PMID: 28541631    Free PMC article.
Neoadjuvant Therapy for Breast Cancer: Established Concepts and Emerging Strategies.
Tessa G Steenbruggen, Mette S van Ramshorst, +3 authors, Gabe S Sonke.
Drugs, 2017 Jun 16; 77(12). PMID: 28616845
Synthetic lethality and cancer.
Nigel J O'Neil, Melanie L Bailey, Philip Hieter.
Nat Rev Genet, 2017 Jun 27; 18(10). PMID: 28649135
Highly Cited. Review.
Shifting paradigm of developing biologics for the treatment of pancreatic adenocarcinoma.
Ying Zeng, Agnieszka A Rucki, Xu Che, Lei Zheng.
J Gastrointest Oncol, 2017 Jul 25; 8(3). PMID: 28736631    Free PMC article.
FDA Approval of PARP Inhibitors and the Impact on Genetic Counseling and Genetic Testing Practices.
Kathryn M Buchtel, Kristen J Vogel Postula, +3 authors, Scott M Weissman.
J Genet Couns, 2017 Aug 07; 27(1). PMID: 28780754
H-Ferritin-nanocaged olaparib: a promising choice for both BRCA-mutated and sporadic triple negative breast cancer.
S Mazzucchelli, M Truffi, +9 authors, F Corsi.
Sci Rep, 2017 Aug 10; 7(1). PMID: 28790402    Free PMC article.
BRCA mutation in ovarian cancer: testing, implications and treatment considerations.
Robert T Neff, Leigha Senter, Ritu Salani.
Ther Adv Med Oncol, 2017 Aug 11; 9(8). PMID: 28794804    Free PMC article.
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Zhor Senhaji Mouhri, Elliot Goodfellow, Bertrand Jean-Claude.
BMC Cancer, 2017 Aug 13; 17(1). PMID: 28800752    Free PMC article.
Understanding Resistance Mechanisms and Expanding the Therapeutic Utility of PARP Inhibitors.
Joline S J Lim, David S P Tan.
Cancers (Basel), 2017 Aug 23; 9(8). PMID: 28829366    Free PMC article.
Radiation Treatment in Women with Ovarian Cancer: Past, Present, and Future.
Emma C Fields, William P McGuire, Lilie Lin, Sarah M Temkin.
Front Oncol, 2017 Sep 06; 7. PMID: 28871275    Free PMC article.
BRCA1 gene: function and deficiency.
Miho Takaoka, Yoshio Miki.
Int J Clin Oncol, 2017 Sep 09; 23(1). PMID: 28884397
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.
Charles-André Philip, Ido Laskov, +8 authors, Amber Yasmeen.
BMC Cancer, 2017 Sep 10; 17(1). PMID: 28886696    Free PMC article.
Bringing new medicines to women with epithelial ovarian cancer: what is the unmet medical need?
Thomas J Herzog, Bradley J Monk.
Gynecol Oncol Res Pract, 2017 Sep 15; 4. PMID: 28904804    Free PMC article.
Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer.
Ana C Gregório, Manuela Lacerda, +3 authors, João Nuno Moreira.
Pathol Oncol Res, 2017 Sep 16; 24(4). PMID: 28913723
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial.
Denise M Wolf, Christina Yau, +18 authors, Laura van 't Veer.
NPJ Breast Cancer, 2017 Sep 28; 3. PMID: 28948212    Free PMC article.
Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice.
Jolien S de Groot, Paul J van Diest, +10 authors, Patrick W B Derksen.
Oncotarget, 2017 Oct 06; 8(37). PMID: 28977823    Free PMC article.
How many diseases is triple negative breast cancer: the protagonism of the immune microenvironment.
Diana P Saraiva, M Guadalupe Cabral, António Jacinto, Sofia Braga.
ESMO Open, 2017 Oct 12; 2(4). PMID: 29018573    Free PMC article.
Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.
Jung-Min Lee, John L Hays, +13 authors, Elise C Kohn.
Oncotarget, 2017 Nov 08; 8(45). PMID: 29108297    Free PMC article.
Current status of poly(ADP-ribose) polymerase inhibitors and future directions.
Akihiro Ohmoto, Shinichi Yachida.
Onco Targets Ther, 2017 Nov 16; 10. PMID: 29138572    Free PMC article.
Highly Cited. Review.
Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways.
Jun Zhao, Yali Li, Jinfang Gao, Yinshan De.
Oncol Lett, 2017 Nov 17; 14(5). PMID: 29142606    Free PMC article.
Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.
Atsushi Osoegawa, Joell J Gills, Shigeru Kawabata, Phillip A Dennis.
Oncotarget, 2017 Nov 21; 8(50). PMID: 29152062    Free PMC article.
Management of hereditary breast and ovarian cancer.
Hideko Yamauchi, Junko Takei.
Int J Clin Oncol, 2017 Dec 01; 23(1). PMID: 29185095
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15.
Rachel M McQuade, Vanesa Stojanovska, +6 authors, Kulmira Nurgali.
Br J Pharmacol, 2017 Dec 02; 175(4). PMID: 29194564    Free PMC article.
BRCA mutations in the manifestation and treatment of ovarian cancer.
Zimin Pan, Xing Xie.
Oncotarget, 2017 Dec 13; 8(57). PMID: 29228641    Free PMC article.
EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.
Raymond W-M Lung, Pok-Man Hau, +16 authors, Kwok-Wai Lo.
J Pathol, 2017 Dec 13; 244(4). PMID: 29230817    Free PMC article.
A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity.
J K Litton, M Scoggins, +14 authors, B K Arun.
NPJ Breast Cancer, 2017 Dec 15; 3. PMID: 29238749    Free PMC article.
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.
Liang Song, Ewan M McNeil, +3 authors, David W Melton.
BMC Cancer, 2017 Dec 20; 17(1). PMID: 29254481    Free PMC article.
Poly (ADP-ribose) polymerase inhibitors in the management of ovarian cancer.
Maurie Markman.
Womens Health (Lond), 2018 Jan 10; 14. PMID: 29313444    Free PMC article.
Precision oncology in the age of integrative genomics.
Chandan Kumar-Sinha, Arul M Chinnaiyan.
Nat Biotechnol, 2018 Jan 11; 36(1). PMID: 29319699    Free PMC article.
Prexasertib, a cell cycle checkpoint kinases 1 and 2 inhibitor, increases in vitro toxicity of PARP inhibition by preventing Rad51 foci formation in BRCA wild type high-grade serous ovarian cancer.
Ethan Brill, Takuhei Yokoyama, +3 authors, Jung-Min Lee.
Oncotarget, 2018 Jan 18; 8(67). PMID: 29340034    Free PMC article.
Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing.
Haitao Yang, MariaLynn Jaeger, +3 authors, Tao Weitao.
J Cancer, 2018 Jan 19; 9(2). PMID: 29344267    Free PMC article.
Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.
Haolong Li, Lei Liu, +2 authors, Da Xing.
Cell Death Dis, 2018 Jan 28; 9(2). PMID: 29374168    Free PMC article.
Pharmacotherapeutic Management of Breast Cancer in Elderly Patients: The Promise of Novel Agents.
Catherine Terret, Chiara Russo.
Drugs Aging, 2018 Feb 02; 35(2). PMID: 29388072
Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going.
Claudia Omarini, Giorgia Guaitoli, +4 authors, Federico Piacentini.
Cancer Manag Res, 2018 Feb 03; 10. PMID: 29391830    Free PMC article.
Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches.
Lucia Guidugli, Hermela Shimelis, +10 authors, Fergus J Couch.
Am J Hum Genet, 2018 Feb 06; 102(2). PMID: 29394989    Free PMC article.
Characterization of mutations in BRCA1/2 and the relationship with clinic-pathological features of breast cancer in a hereditarily high-risk sample of chinese population.
Min Fang, Li Zhu, +6 authors, Yue Yu.
Oncol Lett, 2018 Feb 13; 15(3). PMID: 29435039    Free PMC article.
New therapeutic strategies to treat human cancers expressing mutant p53 proteins.
Giovanni Blandino, Silvia Di Agostino.
J Exp Clin Cancer Res, 2018 Feb 17; 37(1). PMID: 29448954    Free PMC article.
Highly Cited. Review.
PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer.
Robert D Morgan, Andrew R Clamp, +2 authors, Gordon C Jayson.
Cancer Chemother Pharmacol, 2018 Feb 22; 81(4). PMID: 29464354    Free PMC article.
PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation.
Yize Mao, Xin Huang, +5 authors, Shengping Li.
Cancer Med, 2018 Feb 27; 7(4). PMID: 29479816    Free PMC article.
PARP inhibitors for homologous recombination-deficient prostate cancer.
Eric S Christenson, Emmanuel S Antonarakis.
Expert Opin Emerg Drugs, 2018 Mar 30; 23(2). PMID: 29595348    Free PMC article.
Update on PARP Inhibitors in Breast Cancer.
Alexandra S Zimmer, Mitchell Gillard, Stanley Lipkowitz, Jung-Min Lee.
Curr Treat Options Oncol, 2018 Apr 13; 19(5). PMID: 29644491    Free PMC article.
PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside.
Anita A Turk, Kari B Wisinski.
Cancer, 2018 Apr 17; 124(12). PMID: 29660759    Free PMC article.
Spotlight on olaparib in the treatment of BRCA-mutated ovarian cancer: design, development and place in therapy.
Domenica Lorusso, Elisa Tripodi, +4 authors, Francesco Raspagliesi.
Drug Des Devel Ther, 2018 Jun 09; 12. PMID: 29881257    Free PMC article.
Where Do We Stand on the Integration of PARP Inhibitors for the Treatment of Breast Cancer?
Narjust Duma, Kelly C Gast, +2 authors, Ciara C O'Sullivan.
Curr Oncol Rep, 2018 Jun 10; 20(8). PMID: 29884921
Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies.
Evelyn M Brosnan, Carey K Anders.
Ann Transl Med, 2018 Jun 19; 6(9). PMID: 29911111    Free PMC article.
Synthetic Lethal Networks for Precision Oncology: Promises and Pitfalls.
John Paul Shen, Trey Ideker.
J Mol Biol, 2018 Jun 23; 430(18 Pt A). PMID: 29932943    Free PMC article.
Rucaparib in ovarian cancer: an update on safety, efficacy and place in therapy.
Graziela Z Dal Molin, Kohei Omatsu, Anil K Sood, Robert L Coleman.
Ther Adv Med Oncol, 2018 Jul 07; 10. PMID: 29977351    Free PMC article.
Description of Genetic Variants in BRCA Genes in Mexican Patients with Ovarian Cancer: A First Step towards Implementing Personalized Medicine.
Jesus Rolando Delgado-Balderas, Maria Lourdes Garza-Rodriguez, +9 authors, Hugo A Barrera-Saldaña.
Genes (Basel), 2018 Jul 13; 9(7). PMID: 29997359    Free PMC article.
Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies.
Anna Minchom, Caterina Aversa, Juanita Lopez.
Ther Adv Med Oncol, 2018 Jul 20; 10. PMID: 30023007    Free PMC article.
Role of Poly Adenosine Diphosphate Ribose Polymerase Inhibitors in Advanced Stage Ovarian Cancer.
Ena Arora, Muhammad Masab, +3 authors, Gabor Varadi.
Cureus, 2018 Jul 28; 10(5). PMID: 30050740    Free PMC article.
Copy number signatures and mutational processes in ovarian carcinoma.
Geoff Macintyre, Teodora E Goranova, +36 authors, James D Brenton.
Nat Genet, 2018 Aug 15; 50(9). PMID: 30104763    Free PMC article.
Highly Cited.
Advances in the use of PARP inhibitor therapy for breast cancer.
Kelly E McCann, Sara A Hurvitz.
Drugs Context, 2018 Aug 18; 7. PMID: 30116283    Free PMC article.
Risk of selected gastrointestinal toxicities associated with poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of ovarian cancer: a meta-analysis of published trials.
Yongping Liu, Jun Meng, Guichan Wang.
Drug Des Devel Ther, 2018 Oct 03; 12. PMID: 30271116    Free PMC article.
Translational Research Opportunities Regarding Homologous Recombination in Ovarian Cancer.
Margarita Romeo, Juan Carlos Pardo, +6 authors, Ricard Mesía.
Int J Mol Sci, 2018 Oct 24; 19(10). PMID: 30347758    Free PMC article.
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Marta Castroviejo-Bermejo, Cristina Cruz, +36 authors, Violeta Serra.
EMBO Mol Med, 2018 Nov 01; 10(12). PMID: 30377213    Free PMC article.
Highly Cited.
PARP-1 regulates DNA repair factor availability.
Matthew J Schiewer, Amy C Mandigo, +29 authors, Karen E Knudsen.
EMBO Mol Med, 2018 Nov 24; 10(12). PMID: 30467127    Free PMC article.
EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma.
Qiongzhu Dong, Yi Du, +9 authors, Mien-Chie Hung.
Cancer Res, 2018 Dec 24; 79(4). PMID: 30573522    Free PMC article.
Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.
Yoshiyuki Suehara, Deepu Alex, +15 authors, Marc Ladanyi.
Clin Cancer Res, 2019 Jun 09; 25(21). PMID: 31175097    Free PMC article.
A decade of clinical development of PARP inhibitors in perspective.
J Mateo, C J Lord, +7 authors, J S de Bono.
Ann Oncol, 2019 Jun 21; 30(9). PMID: 31218365    Free PMC article.
Highly Cited. Review.
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast Cancer to Ionizing Radiation.
Anna R Michmerhuizen, Andrea M Pesch, +13 authors, Corey Speers.
Mol Cancer Ther, 2019 Aug 16; 18(11). PMID: 31413177    Free PMC article.
Relationship between Microsatellite Instability, Immune Cells Infiltration, and Expression of Immune Checkpoint Molecules in Ovarian Carcinoma: Immunotherapeutic Strategies for the Future.
Hitomi Yamashita, Kentaro Nakayama, +11 authors, Satoru Kyo.
Int J Mol Sci, 2019 Oct 19; 20(20). PMID: 31623180    Free PMC article.
Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting.
Julian Biau, Emmanuel Chautard, Pierre Verrelle, Marie Dutreix.
Front Oncol, 2019 Oct 28; 9. PMID: 31649878    Free PMC article.
MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair.
Penelope D Ruiz, Gregory A Hamilton, Jong Woo Park, Matthew J Gamble.
Mol Cell Biol, 2019 Oct 23; 40(1). PMID: 31636161    Free PMC article.
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer.
Robert L Coleman, Gini F Fleming, +29 authors, Michael A Bookman.
N Engl J Med, 2019 Sep 29; 381(25). PMID: 31562800    Free PMC article.
Highly Cited.
Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy.
Michael Friedlander, Ursula Matulonis, +18 authors, Jonathan Ledermann.
Br J Cancer, 2018 Oct 26; 119(9). PMID: 30353045    Free PMC article.
An exceptional response to olaparib in relapsed and refractory BRCA2 mutated non-small cell lung cancer in hereditary breast-ovarian cancer syndrome.
Vikas T Talreja, Vanita Noronha, +2 authors, Kumar Prabhash.
South Asian J Cancer, 2020 Jan 21; 9(1). PMID: 31956609    Free PMC article.
CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.
Rachel L Mintz, Yeh-Hsing Lao, +8 authors, Kam W Leong.
Bioeng Transl Med, 2020 Jan 29; 5(1). PMID: 31989039    Free PMC article.
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
Chenggong Sun, Wenyu Cao, +8 authors, Beihua Kong.
J Hematol Oncol, 2020 Feb 02; 13(1). PMID: 32005272    Free PMC article.
Synergistic clinical efficacy of niraparib in combination with pembrolizumab in patients with recurrent platinum-resistant ovarian carcinoma.
Joan Tymon-Rosario, Burak Zeybek, Chanhee Han, Alessandro D Santin.
Ann Transl Med, 2020 Feb 06; 7(Suppl 8). PMID: 32016027    Free PMC article.
An Effective Epigenetic-PARP Inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA Mutations.
Nicholas Pulliam, Fang Fang, +10 authors, Kenneth P Nephew.
Clin Cancer Res, 2018 Apr 05; 24(13). PMID: 29615458    Free PMC article.
Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types.
Lucy Gentles, Bojidar Goranov, +7 authors, Rachel L O'Donnell.
Cancers (Basel), 2019 Mar 16; 11(3). PMID: 30871186    Free PMC article.
Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations.
Yolanda Jerez, Ivan Márquez-Rodas, +3 authors, Sara López-Tarruella.
Drugs, 2019 Dec 12; 80(2). PMID: 31823331
Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer.
Nan Shao, Yawei Shi, +5 authors, Ying Lin.
Int J Biol Sci, 2019 Jun 12; 15(5). PMID: 31182917    Free PMC article.
Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.
Panagiotis A Konstantinopoulos, William T Barry, +25 authors, Ursula A Matulonis.
Lancet Oncol, 2019 Mar 19; 20(4). PMID: 30880072    Free PMC article.
Highly Cited.
Epithelial ovarian cancer risk: A review of the current genetic landscape.
Nicola Flaum, Emma J Crosbie, +2 authors, Dafydd G Evans.
Clin Genet, 2019 May 18; 97(1). PMID: 31099061    Free PMC article.
PARP Inhibitors in Gynecologic Cancers: What Is the Next Big Development?
Michelle Lightfoot, Lauren Montemorano, Kristin Bixel.
Curr Oncol Rep, 2020 Feb 19; 22(3). PMID: 32067102
Combination of PARP inhibitor and temozolomide to suppress chordoma progression.
Xiaoyu Cao, Yanxin Lu, +10 authors, Chunzhang Yang.
J Mol Med (Berl), 2019 Jun 16; 97(8). PMID: 31201471    Free PMC article.
Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer.
Angela George, Stan Kaye, Susana Banerjee.
Nat Rev Clin Oncol, 2016 Dec 14; 14(5). PMID: 27958297
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
Sarah J Hill, Brennan Decker, +19 authors, Alan D D'Andrea.
Cancer Discov, 2018 Sep 15; 8(11). PMID: 30213835    Free PMC article.
Highly Cited.
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes.
Darren R Hodgson, Brian A Dougherty, +16 authors, J Carl Barrett.
Br J Cancer, 2018 Oct 26; 119(11). PMID: 30353044    Free PMC article.
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness.
Jianfeng Shen, Wei Zhao, +6 authors, Guang Peng.
Cancer Res, 2018 Nov 30; 79(2). PMID: 30482774    Free PMC article.
Highly Cited.
Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer.
Chee Khoon Lee, Clare Scott, +11 authors, Michael Friedlander.
Br J Cancer, 2019 Jan 19; 120(3). PMID: 30655615    Free PMC article.
53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
Rachel M Hurley, Andrea E Wahner Hendrickson, +19 authors, Scott H Kaufmann.
Gynecol Oncol, 2019 Jan 29; 153(1). PMID: 30686551    Free PMC article.
Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.
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