Journal Article
. 2011 Sep; 43(5):702-7.
doi: 10.1016/j.humpath.2011.06.017.

Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study

Shaimaa Al-Janabi 1 André Huisman  Aryan Vink  Roos J Leguit  G Johan A Offerhaus  Fiebo J W ten Kate  Paul J van Diest  
Affiliations
  • PMID: 21937077
  •     31 citations

Abstract

During the last decade, whole slide images have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation, and quality assurance testing. However, whole slide images have as yet not much been used for up-front diagnostics because of the lack of validation studies. The aim of this study was, therefore, to test the feasibility of whole slide images for diagnosis of gastrointestinal tract specimens, one of the largest areas of diagnostic pathology. One hundred gastrointestinal tract biopsies and resections that had been diagnosed using light microscopy 1 year before were rediagnosed on whole slide images scanned at ×20 magnification by 5 pathologists (all reassessing their own cases), having the original clinical information available but blinded to their original light microscopy diagnoses. The original light microscopy and whole slide image-based diagnoses were compared and classified as concordant, slightly discordant (without clinical consequences), and discordant. The diagnoses based on light microscopy and the whole slide image-based rediagnoses were concordant in 95% of the cases. Light microscopy and whole slide image diagnosis in the remaining 5% of cases were slightly discordant, none of these were with clinical or prognostic implications. Up-front histopathologic diagnosis of gastrointestinal biopsies and resections can be done on whole slide images.

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Application of whole slide image markup and annotation for pathologist knowledge capture.
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Intra-observer reproducibility of whole slide imaging for the primary diagnosis of breast needle biopsies.
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Implementation of large-scale routine diagnostics using whole slide imaging in Sweden: Digital pathology experiences 2006-2013.
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Clinical and pathological correlates of severity classifications in trigger fingers based on computer-aided image analysis.
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A comparative study of input devices for digital slide navigation.
Jesper Molin, Claes Lundström, Morten Fjeld.
J Pathol Inform, 2015 Mar 17; 6. PMID: 25774318    Free PMC article.
Digital slide viewing for primary reporting in gastrointestinal pathology: a validation study.
Maurice B Loughrey, Paul J Kelly, +5 authors, Peter W Hamilton.
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Nanoscale refractive index fluctuations detected via sparse spectral microscopy.
John E Chandler, Lusik Cherkezyan, Hariharan Subramanian, Vadim Backman.
Biomed Opt Express, 2016 May 28; 7(3). PMID: 27231596    Free PMC article.
Interobserver Agreement Using Histological Scoring of the Canine Liver.
J A Lidbury, A Rodrigues Hoffmann, +7 authors, J M Steiner.
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Digital pathology in nephrology clinical trials, research, and pathology practice.
Laura Barisoni, Jeffrey B Hodgin.
Curr Opin Nephrol Hypertens, 2017 Sep 01; 26(6). PMID: 28858910    Free PMC article.
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Being fully digital: perspective of a Dutch academic pathology laboratory.
Nikolas Stathonikos, Tri Q Nguyen, +2 authors, Paul J van Diest.
Histopathology, 2019 Jul 14; 75(5). PMID: 31301690    Free PMC article.
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Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center.
Liron Pantanowitz, John H Sinard, +8 authors, College of American Pathologists Pathology and Laboratory Quality Center.
Arch Pathol Lab Med, 2013 May 03; 137(12). PMID: 23634907    Free PMC article.
Highly Cited. Review.
Validation of a digital pathology system including remote review during the COVID-19 pandemic.
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J Pathol Inform, 2019 Jan 05; 9. PMID: 30607307    Free PMC article.
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Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.
Bih-Rong Wei, Charles H Halsey, +21 authors, R Mark Simpson.
Acad Pathol, 2019 Jul 20; 6. PMID: 31321298    Free PMC article.
Head-tracking as an interface device for image control in digital pathology: a comparative study.
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Digital pathology in the time of corona.
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J Clin Pathol, 2020 Jul 24; 73(11). PMID: 32699117    Free PMC article.
Review.
Recommendations for pathologic practice using digital pathology: consensus report of the Korean Society of Pathologists.
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J Pathol Transl Med, 2020 Oct 08; 54(6). PMID: 33027850    Free PMC article.
Review.
The performance of digital microscopy for primary diagnosis in human pathology: a systematic review.
Anna Luíza Damaceno Araújo, Lady Paola Aristizábal Arboleda, +13 authors, Alan Roger Santos-Silva.
Virchows Arch, 2019 Jan 28; 474(3). PMID: 30685784
Systematic Review.
Regional registration of whole slide image stacks containing major histological artifacts.
Mahsa Paknezhad, Sheng Yang Michael Loh, +11 authors, Hwee Kuan Lee.
BMC Bioinformatics, 2020 Dec 06; 21(1). PMID: 33276732    Free PMC article.
Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia: a multi-institutional study.
P-B Diniz, M Sena-Filho, +4 authors, J Jorge.
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Rapid Validation of Whole-Slide Imaging for Primary Histopathology Diagnosis.
Megan I Samuelson, Stephanie J Chen, +5 authors, Anand Rajan K D.
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Review.
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