Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection

Chao Shi ¹, Tobias M Hohl , Ingrid Leiner , Michele J Equinda , Xiaozhou Fan , Eric G Pamer

Affiliations

¹ Immunology Program, Sloan-Kettering Institute, Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

PMID: 21976773
41 References
79 citations

Abstract

Listeria monocytogenes is a facultative intracellular bacterium that causes systemic infections in immunocompromised hosts. Early recruitment of myeloid cells, including inflammatory monocytes and neutrophils, to sites of L. monocytogenes infection is essential for the control of infection and host survival. Because previous experimental studies used depleting or blocking Abs that affected both inflammatory monocytes and neutrophils, the relative contributions of these cell populations to defense against L. monocytogenes infection remain incompletely defined. In this article, we used highly selective depletion strategies to either deplete inflammatory monocytes or neutrophils from L. monocytogenes-infected mice and demonstrate that neutrophils are dispensable for early and late control of infection. In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection.

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Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice. Yuanjiu Lei, Camila Guerra Martinez, +7 authors, A Phillip West. less Sci Adv, 2021 May 28; 7(22). PMID: 34039599 Free PMC article.
Leishmania donovani Metacyclic Promastigotes Impair Phagosome Properties in Inflammatory Monocytes. Christine Matte, Guillermo Arango Duque, Albert Descoteaux. Infect Immun, 2021 Apr 21; 89(7). PMID: 33875473 Free PMC article.
Tacrolimus exposure windows responsible for Listeria monocytogenes infection susceptibility. Hilary Miller-Handley, John J Erickson, +3 authors, Sing Sing Way. less Transpl Infect Dis, 2021 Jun 01; 23(4). PMID: 34057792 Free PMC article.
Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice. Young-Jun Ju, Kyung-Min Lee, +8 authors, Cheol-Heui Yun. less Immune Netw, 2022 May 17; 22(2). PMID: 35573152 Free PMC article.

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