Journal Article
. 2011 Oct; 187(10):5293-8.
doi: 10.4049/jimmunol.1101721.

Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection

Chao Shi 1 Tobias M Hohl  Ingrid Leiner  Michele J Equinda  Xiaozhou Fan  Eric G Pamer  
Affiliations
  • PMID: 21976773
  •     41 References
  •     79 citations

Abstract

Listeria monocytogenes is a facultative intracellular bacterium that causes systemic infections in immunocompromised hosts. Early recruitment of myeloid cells, including inflammatory monocytes and neutrophils, to sites of L. monocytogenes infection is essential for the control of infection and host survival. Because previous experimental studies used depleting or blocking Abs that affected both inflammatory monocytes and neutrophils, the relative contributions of these cell populations to defense against L. monocytogenes infection remain incompletely defined. In this article, we used highly selective depletion strategies to either deplete inflammatory monocytes or neutrophils from L. monocytogenes-infected mice and demonstrate that neutrophils are dispensable for early and late control of infection. In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection.

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Am J Respir Cell Mol Biol, 2019 Feb 16; 61(2). PMID: 30768917    Free PMC article.
Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations.
Debabrata Patra, Joongho Kim, +2 authors, Linda J Sandell.
Biol Open, 2020 Jun 25; 9(6). PMID: 32576566    Free PMC article.
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.
Michelle M Lissner, Katherine Cumnock, +5 authors, David Schneider.
Elife, 2020 Oct 07; 9. PMID: 33021470    Free PMC article.
Live Imaging of Innate and Adaptive Immune Responses in the Liver.
Lu Li, Zhutian Zeng.
Front Immunol, 2020 Oct 13; 11. PMID: 33042143    Free PMC article.
Review.
Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections.
Eleonora Ciarlo, Tytti Heinonen, +4 authors, Thierry Roger.
J Infect Dis, 2020 Jan 01; 222(11). PMID: 31889191    Free PMC article.
Secretion of c-di-AMP by Listeria monocytogenes Leads to a STING-Dependent Antibacterial Response during Enterocolitis.
Alexander Louie, Varaang Bhandula, Daniel A Portnoy.
Infect Immun, 2020 Oct 07; 88(12). PMID: 33020211    Free PMC article.
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Sandy R Larson, Nikki Bortell, +3 authors, Laurel L Lenz.
Front Immunol, 2020 Dec 29; 11. PMID: 33363536    Free PMC article.
PRAK Promotes the Pathogen Clearance by Macrophage Through Regulating Autophagy and Inflammasome Activation.
Ligu Mi, Yan Wang, +4 authors, Yu Zhang.
Front Immunol, 2021 May 04; 12. PMID: 33936034    Free PMC article.
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
Yuanjiu Lei, Camila Guerra Martinez, +7 authors, A Phillip West.
Sci Adv, 2021 May 28; 7(22). PMID: 34039599    Free PMC article.
Leishmania donovani Metacyclic Promastigotes Impair Phagosome Properties in Inflammatory Monocytes.
Christine Matte, Guillermo Arango Duque, Albert Descoteaux.
Infect Immun, 2021 Apr 21; 89(7). PMID: 33875473    Free PMC article.
Tacrolimus exposure windows responsible for Listeria monocytogenes infection susceptibility.
Hilary Miller-Handley, John J Erickson, +3 authors, Sing Sing Way.
Transpl Infect Dis, 2021 Jun 01; 23(4). PMID: 34057792    Free PMC article.
Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice.
Young-Jun Ju, Kyung-Min Lee, +8 authors, Cheol-Heui Yun.
Immune Netw, 2022 May 17; 22(2). PMID: 35573152    Free PMC article.