Journal Article
. 2011 Dec;19(5).
doi: 10.1245/s10434-011-2108-2.

Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer

Manfred Kaufmann 1 Gunter von Minckwitz  Elefhterios P Mamounas  David Cameron  Lisa A Carey  Massimo Cristofanilli  Carsten Denkert  Wolfgang Eiermann  Michael Gnant  Jay R Harris  Thomas Karn  Cornelia Liedtke  Davide Mauri  Roman Rouzier  Eugen Ruckhaeberle  Vladimir Semiglazov  W Fraser Symmans  Andrew Tutt  Lajos Pusztai  
  • PMID: 22193884
  •     131 citations


The use of neoadjuvant systemic therapy (NST) for the treatment of primary breast cancer has constantly increased, especially in trials of new therapeutic regimens. In the 1980 s, NST was shown to substantially improve breast-conserving surgery rates and was first typically used for patients with inoperable locally advanced or inflammatory breast cancer. Investigators have since also used NST as an in vivo test for chemosensitivity by assessing pathologic complete response. Today, by using pathologic response and other biomarkers as intermediate end points, results from trials of new regimens and therapies that use NST are aimed to precede and anticipate the results from larger adjuvant trials. In 2003, a panel of representatives from various breast cancer clinical research groups was first convened in Biedenkopf to formulate recommendations on the use of NST. The obtained consensus was updated in two subsequent meetings in 2004 and 2006. The most recent conference on recommendations on the use of NST took place in 2010 and forms the basis of this report.

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Eur Radiol Exp, 2020 Feb 07; 4(1). PMID: 32026095    Free PMC article.
Clinical and biological impact of miR-18a expression in breast cancer after neoadjuvant chemotherapy.
Ginés Luengo-Gil, Elena García-Martínez, +7 authors, Francisco Ayala de la Peña.
Cell Oncol (Dordr), 2019 May 23; 42(5). PMID: 31115881
The Diagnostic Performance of DCE-MRI in Evaluating the Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer: A Meta-Analysis.
Qingqing Cheng, Jiaxi Huang, +4 authors, Liangping Luo.
Front Oncol, 2020 Mar 03; 10. PMID: 32117747    Free PMC article.
Systematic Review.
Post-chemotherapy target volumes are safe as boost volume for intact breast radiotherapy in locally advanced breast cancer.
Sushma Agrawal, Waseem Raza, +2 authors, Gaurav Agarwal.
Rep Pract Oncol Radiother, 2020 Mar 07; 25(2). PMID: 32140084    Free PMC article.
Drug Combinations in Breast Cancer Therapy.
Funmilola A Fisusi, Emmanuel O Akala.
Pharm Nanotechnol, 2019 Jan 23; 7(1). PMID: 30666921    Free PMC article.
Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement.
Ramon Colomer, Cristina Saura, +7 authors, Ana Lluch.
Oncologist, 2019 Feb 03; 24(5). PMID: 30710068    Free PMC article.
Early Prediction of Breast Cancer Therapy Response using Multiresolution Fractal Analysis of DCE-MRI Parametric Maps.
Archana Machireddy, Guillaume Thibault, +12 authors, Xubo Song.
Tomography, 2019 Mar 12; 5(1). PMID: 30854446    Free PMC article.
Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System.
Suniza Jamaris, Leyla Akpolat-Basci, +7 authors, Hans-Christian Kolberg.
Breast Care (Basel), 2019 Dec 05; 14(5). PMID: 31798390    Free PMC article.
Pathologic Response After Weekly Paclitaxel versus Docetaxel in Operable Breast Cancer.
Xenia Elena Bacinschi, Rodica Maricela Anghel, +3 authors, Silvia Mihaela Ilie.
Cancer Manag Res, 2020 Mar 13; 12. PMID: 32161494    Free PMC article.
Changes in Cytokeratin 18 during Neoadjuvant Chemotherapy of Breast Cancer: A Prospective Study.
Danial Fazilat-Panah, Somaye Vakili Ahrari Roudi, +5 authors, Seyed Alireza Javadinia.
Iran J Pathol, 2020 Mar 28; 15(2). PMID: 32215027    Free PMC article.
Factors Influencing the Onset of Neoadjuvant Therapy in Breast Cancer Patients.
Carolin Müller, Stephanie Juhasz-Böss, +3 authors, Georg-Peter Breitbach.
Breast Care (Basel), 2020 May 14; 15(2). PMID: 32398988    Free PMC article.
The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan.
Chih-Chiang Hung, Youngsen Yang, +3 authors, Jie-Ru Yang.
Biochem Res Int, 2020 May 14; 2020. PMID: 32399300    Free PMC article.
Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.
Bernhard Tribukait.
BMC Cancer, 2020 May 20; 20(1). PMID: 32423477    Free PMC article.
Amplifications of stemness genes and the capacity of breast tumors for metastasis.
Nikolai Litviakov, Marina Ibragimova, +7 authors, Elena Slonimskaya.
Oncotarget, 2020 Jun 12; 11(21). PMID: 32523653    Free PMC article.
Assessment of the Predictive Role of Serum Lipid Profiles in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.
Fanli Qu, Rui Chen, +6 authors, Shengchun Liu.
J Breast Cancer, 2020 Jul 01; 23(3). PMID: 32595987    Free PMC article.
Sentinel Node Biopsy After Neoadjuvant Systemic Therapy for Breast Cancer: The Method Matters.
Harry D Bear, Kandace P McGuire.
Ann Surg Oncol, 2019 Apr 26; 26(8). PMID: 31020504    Free PMC article.
Choosing Wisely Africa: Ten Low-Value or Harmful Practices That Should Be Avoided in Cancer Care.
Fidel Rubagumya, Gunita Mitera, +12 authors, Nazik Hammad.
JCO Glob Oncol, 2020 Aug 01; 6. PMID: 32735489    Free PMC article.
Combination of pegylated liposomal doxorubicin and docetaxel as neoadjuvant therapy for breast cancer with axillary lymph node metastasis.
Li Wang, Yang Hong, +4 authors, Yunjiang Liu.
J Int Med Res, 2020 Aug 11; 48(8). PMID: 32776809    Free PMC article.
Gene signature-based prediction of triple-negative breast cancer patient response to Neoadjuvant chemotherapy.
Yanding Zhao, Evelien Schaafsma, Chao Cheng.
Cancer Med, 2020 Jul 22; 9(17). PMID: 32692484    Free PMC article.
Examination of Tumor Regression Grading Systems in Breast Cancer Patients Who Received Neoadjuvant Therapy.
Anita Sejben, Renáta Kószó, +2 authors, Tamás Zombori.
Pathol Oncol Res, 2020 Jul 22; 26(4). PMID: 32691390    Free PMC article.
A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer.
Yueyao Du, Tingting Yan, +2 authors, Jinsong Lu.
Breast Cancer (Dove Med Press), 2018 Dec 21; 10. PMID: 30568487    Free PMC article.
Exploring women's experiences with a decision aid for neoadjuvant systemic therapy for operable breast cancer.
Anne Herrmann, Frances Boyle, +2 authors, Nicholas Zdenkowski.
Health Sci Rep, 2017 Aug 22; 1(1). PMID: 30623032    Free PMC article.
Targeted neoadjuvant therapy in the HER-2-positive breast cancer patients: a systematic review and meta-analysis.
Wenhua Ma, Fugang Zhao, +4 authors, Peng Xie.
Onco Targets Ther, 2019 Jan 19; 12. PMID: 30655674    Free PMC article.
Primary medical therapy and breast conservation treatment: the medical oncology perspective.
Nan Soon Wong.
Gland Surg, 2019 Jan 29; 7(6). PMID: 30687629    Free PMC article.
The role of IRAK1 in breast cancer patients treated with neoadjuvant chemotherapy.
Muwen Yang, Xingsong Qin, Guangyuan Qin, Xinyu Zheng.
Onco Targets Ther, 2019 Apr 17; 12. PMID: 30988621    Free PMC article.
Interaction of tumor-associated macrophages and cancer chemotherapy.
Irina Larionova, Nadezhda Cherdyntseva, +3 authors, Julia Kzhyshkowska.
Oncoimmunology, 2019 May 31; 8(7). PMID: 31143517    Free PMC article.
Highly Cited. Review.
Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer.
Yueyao Du, Liheng Zhou, +3 authors, Jinsong Lu.
Ann Transl Med, 2019 Jun 04; 7(7). PMID: 31157259    Free PMC article.
LncRNA Profile Study Reveals a Three-LncRNA Signature Associated With the Pathological Complete Response Following Neoadjuvant Chemotherapy in Breast Cancer.
Ying Zeng, Guo Wang, +6 authors, Yuan-Shan Zhu.
Front Pharmacol, 2019 Jun 14; 10. PMID: 31191314    Free PMC article.
The treatment option of progressive disease in breast cancer during neoadjuvant chemotherapy: a single-center experience.
Yurong Zheng, Xiaowen Ding, +6 authors, Yang Yu.
Cancer Biol Ther, 2020 May 19; 21(8). PMID: 32420815    Free PMC article.
Inflammatory Markers Predicting Pathological Complete Response in Cases with Breast Cancer Treated by Neoadjuvant Chemotherapy.
Mahmut Büyükşimşek, Ali Oğul, Cem Mirili, Semra Paydaş.
Eur J Breast Health, 2020 Oct 17; 16(4). PMID: 33062961    Free PMC article.
FZR1 as a novel biomarker for breast cancer neoadjuvant chemotherapy prediction.
Shuo Liu, Haobin Wang, +7 authors, Shijing Yue.
Cell Death Dis, 2020 Sep 27; 11(9). PMID: 32978372    Free PMC article.
Contrast-enhanced ultrasound for evaluating the pathologic response of breast cancer to neoadjuvant chemotherapy: A meta-analysis.
Kun Jia, Li Li, +2 authors, Hong Yuan Xue.
Medicine (Baltimore), 2019 Jan 27; 98(4). PMID: 30681622    Free PMC article.
Time to initiation of neo-adjuvant chemotherapy for breast cancer treatment does not influence patient survival: A study of US breast cancer patients.
Devon Livingston-Rosanoff, Bret Hanlon, +6 authors, Lee G Wilke.
Breast J, 2019 Sep 13; 26(4). PMID: 31513322    Free PMC article.
Accuracy of Magnetic Resonance Imaging-Guided Biopsy to Verify Breast Cancer Pathologic Complete Response After Neoadjuvant Chemotherapy: A Nonrandomized Controlled Trial.
Elizabeth J Sutton, Lior Z Braunstein, +18 authors, Elizabeth A Morris.
JAMA Netw Open, 2021 Jan 16; 4(1). PMID: 33449096    Free PMC article.
Contrast-Enhanced Ultrasonography in the Diagnosis and Treatment Modulation of Breast Cancer.
Ioana Boca Bene, Sorin M Dudea, Anca I Ciurea.
J Pers Med, 2021 Feb 13; 11(2). PMID: 33573122    Free PMC article.