Journal Article
. 2012 Feb;2().
doi: 10.1038/srep00227.

A gene signature for predicting outcome in patients with basal-like breast cancer

Robin M Hallett 1 Anna Dvorkin-Gheva  Anita Bane  John A Hassell  
  • PMID: 22355741
  •     50 References
  •     31 citations

No abstract available

Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancer.
Leonel F Hernandez-Aya, Mariana Chavez-Macgregor, +8 authors, Ana Maria Gonzalez-Angulo.
J Clin Oncol, 2011 May 25; 29(19). PMID: 21606433    Free PMC article.
Ins and outs of ADF/cofilin activity and regulation.
Marleen Van Troys, Lynn Huyck, +3 authors, Christophe Ampe.
Eur J Cell Biol, 2008 May 24; 87(8-9). PMID: 18499298
Highly Cited. Review.
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.
Fiona M Blows, Kristy E Driver, +40 authors, David Huntsman.
PLoS Med, 2010 Jun 04; 7(5). PMID: 20520800    Free PMC article.
Highly Cited.
The cofilin pathway in breast cancer invasion and metastasis.
Weigang Wang, Robert Eddy, John Condeelis.
Nat Rev Cancer, 2007 May 25; 7(6). PMID: 17522712    Free PMC article.
Highly Cited. Review.
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors.
Jason I Herschkowitz, Karl Simin, +23 authors, Charles M Perou.
Genome Biol, 2007 May 12; 8(5). PMID: 17493263    Free PMC article.
Highly Cited.
An algorithm to discover gene signatures with predictive potential.
Robin M Hallett, Anna Dvorkin, Christine M Gabardo, John A Hassell.
J Exp Clin Cancer Res, 2010 Sep 04; 29. PMID: 20813028    Free PMC article.
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.
Howard Y Chang, Dimitry S A Nuyten, +10 authors, Marc J van de Vijver.
Proc Natl Acad Sci U S A, 2005 Feb 11; 102(10). PMID: 15701700    Free PMC article.
Highly Cited.
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.
Weigang Wang, Sumanta Goswami, +6 authors, John S Condeelis.
Cancer Res, 2004 Dec 03; 64(23). PMID: 15574765
Highly Cited.
Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series.
Christine Desmedt, Fanny Piette, +18 authors, TRANSBIG Consortium.
Clin Cancer Res, 2007 Jun 05; 13(11). PMID: 17545524
Highly Cited.
Supervised risk predictor of breast cancer based on intrinsic subtypes.
Joel S Parker, Michael Mullins, +17 authors, Philip S Bernard.
J Clin Oncol, 2009 Feb 11; 27(8). PMID: 19204204    Free PMC article.
Highly Cited.
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer.
Marc Buyse, Sherene Loi, +18 authors, TRANSBIG Consortium.
J Natl Cancer Inst, 2006 Sep 07; 98(17). PMID: 16954471
Highly Cited.
Molecular portraits of human breast tumours.
C M Perou, T Sørlie, +15 authors, D Botstein.
Nature, 2000 Aug 30; 406(6797). PMID: 10963602
Highly Cited.
Gene expression profiling predicts clinical outcome of breast cancer.
Laura J van 't Veer, Hongyue Dai, +13 authors, Stephen H Friend.
Nature, 2002 Feb 02; 415(6871). PMID: 11823860
Highly Cited.
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.
Isabelle Goulet, Sophie Boisvenue, +2 authors, Jocelyn Côté.
Hum Mol Genet, 2008 Jul 18; 17(19). PMID: 18632687    Free PMC article.
Frozen robust multiarray analysis (fRMA).
Matthew N McCall, Benjamin M Bolstad, Rafael A Irizarry.
Biostatistics, 2010 Jan 26; 11(2). PMID: 20097884    Free PMC article.
Highly Cited.
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer.
Andrew E Teschendorff, Ahmad Miremadi, +2 authors, Carlos Caldas.
Genome Biol, 2007 Aug 09; 8(8). PMID: 17683518    Free PMC article.
Highly Cited.
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures.
Pratyaksha Wirapati, Christos Sotiriou, +10 authors, Mauro Delorenzi.
Breast Cancer Res, 2008 Jul 30; 10(4). PMID: 18662380    Free PMC article.
Highly Cited.
Prognostic effect of basal-like breast cancers is time dependent: evidence from tissue microarray studies on a lymph node-negative cohort.
Anna Marie Mulligan, Dushanthi Pinnaduwage, +2 authors, Irene L Andrulis.
Clin Cancer Res, 2008 Jul 03; 14(13). PMID: 18593996
Proteasome inhibitors in cancer therapy: lessons from the first decade.
Robert Z Orlowski, Deborah J Kuhn.
Clin Cancer Res, 2008 Mar 19; 14(6). PMID: 18347166
Highly Cited. Review.
Repeated observation of breast tumor subtypes in independent gene expression data sets.
Therese Sorlie, Robert Tibshirani, +13 authors, David Botstein.
Proc Natl Acad Sci U S A, 2003 Jun 28; 100(14). PMID: 12829800    Free PMC article.
Highly Cited.
Assessing the clinical impact of prognostic factors: when is "statistically significant" clinically useful?
D F Hayes, B Trock, A L Harris.
Breast Cancer Res Treat, 1999 Mar 05; 52(1-3). PMID: 10066089
Prognostic markers in triple-negative breast cancer.
Emad A Rakha, Maysa E El-Sayed, +3 authors, Ian O Ellis.
Cancer, 2006 Dec 06; 109(1). PMID: 17146782
Highly Cited.
Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4.
Yan Xie, Dennis W Wolff, +7 authors, Yaping Tu.
Cancer Res, 2009 Jun 25; 69(14). PMID: 19549919    Free PMC article.
Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray.
Takemitsu Nagahata, Masamitsu Onda, +12 authors, Tatsuhiko Tsunoda.
Cancer Sci, 2004 Mar 16; 95(3). PMID: 15016320
Predicting the clinical status of human breast cancer by using gene expression profiles.
M West, C Blanchette, +7 authors, J R Nevins.
Proc Natl Acad Sci U S A, 2001 Sep 20; 98(20). PMID: 11562467    Free PMC article.
Highly Cited.
Kinome expression profiling and prognosis of basal breast cancers.
Renaud Sabatier, Pascal Finetti, +7 authors, François Bertucci.
Mol Cancer, 2011 Jul 23; 10. PMID: 21777462    Free PMC article.
Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.
Kenneth R Hess, Keith Anderson, +14 authors, Lajos Pusztai.
J Clin Oncol, 2006 Aug 10; 24(26). PMID: 16896004
Highly Cited.
Adjusting batch effects in microarray expression data using empirical Bayes methods.
W Evan Johnson, Cheng Li, Ariel Rabinovic.
Biostatistics, 2006 Apr 25; 8(1). PMID: 16632515
Highly Cited.
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.
Bas Kreike, Marieke van Kouwenhove, +4 authors, Marc J van de Vijver.
Breast Cancer Res, 2007 Oct 04; 9(5). PMID: 17910759    Free PMC article.
Highly Cited.
Triple-negative breast cancer: an unmet medical need.
Clifford A Hudis, Luca Gianni.
Oncologist, 2011 Feb 10; 16 Suppl 1. PMID: 21278435
Highly Cited. Review.
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.
Soonmyung Paik, Steven Shak, +12 authors, Norman Wolmark.
N Engl J Med, 2004 Dec 14; 351(27). PMID: 15591335
Highly Cited.
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang, Jan G M Klijn, +11 authors, John A Foekens.
Lancet, 2005 Feb 22; 365(9460). PMID: 15721472
Highly Cited.
T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers.
Achim Rody, Uwe Holtrich, +10 authors, Manfred Kaufmann.
Breast Cancer Res, 2009 Mar 11; 11(2). PMID: 19272155    Free PMC article.
Highly Cited.
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature.
Andrew Tutt, Alice Wang, +21 authors, Fred Waldman.
BMC Cancer, 2008 Nov 26; 8. PMID: 19025599    Free PMC article.
E2F1 and KIAA0191 expression predicts breast cancer patient survival.
Robin M Hallett, John A Hassell.
BMC Res Notes, 2011 Apr 02; 4. PMID: 21453498    Free PMC article.
Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome.
Johan Staaf, Markus Ringnér, +15 authors, Ake Borg.
J Clin Oncol, 2010 Mar 17; 28(11). PMID: 20231686
A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer.
Christina Yau, Laura Esserman, +3 authors, Christopher C Benz.
Breast Cancer Res, 2010 Oct 16; 12(5). PMID: 20946665    Free PMC article.
Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity.
Anne Vincent-Salomon, Nadège Gruel, +16 authors, Alain Aurias.
Breast Cancer Res, 2007 Apr 10; 9(2). PMID: 17417968    Free PMC article.
Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up.
R L Ridolfi, P P Rosen, +2 authors, V Miké.
Cancer, 1977 Oct 01; 40(4). PMID: 907958
Highly Cited.
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.
Christos Sotiriou, Pratyaksha Wirapati, +17 authors, Mauro Delorenzi.
J Natl Cancer Inst, 2006 Feb 16; 98(4). PMID: 16478745
Highly Cited.
1997 update of recommendations for the use of tumor markers in breast and colorectal cancer. Adopted on November 7, 1997 by the American Society of Clinical Oncology.
J Clin Oncol, 1998 Feb 20; 16(2). PMID: 9469371
A gene-expression signature as a predictor of survival in breast cancer.
Marc J van de Vijver, Yudong D He, +18 authors, René Bernards.
N Engl J Med, 2002 Dec 20; 347(25). PMID: 12490681
Highly Cited.
Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes.
Christine Desmedt, Benjamin Haibe-Kains, +6 authors, Christos Sotiriou.
Clin Cancer Res, 2008 Aug 14; 14(16). PMID: 18698033
Highly Cited.
Triple-negative breast cancer: clinical features and patterns of recurrence.
Rebecca Dent, Maureen Trudeau, +7 authors, Steven A Narod.
Clin Cancer Res, 2007 Aug 03; 13(15 Pt 1). PMID: 17671126
Highly Cited.
Gene signature evaluation as a prognostic tool: challenges in the design of the MINDACT trial.
Jan Bogaerts, Fatima Cardoso, +12 authors, TRANSBIG consortium.
Nat Clin Pract Oncol, 2006 Oct 05; 3(10). PMID: 17019432
The proteasome and proteasome inhibitors in cancer therapy.
Peter M Voorhees, Robert Z Orlowski.
Annu Rev Pharmacol Toxicol, 2006 Jan 13; 46. PMID: 16402903
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
T Sørlie, C M Perou, +14 authors, A L Børresen-Dale.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553815    Free PMC article.
Highly Cited.
A comparative study of survival models for breast cancer prognostication based on microarray data: does a single gene beat them all?
B Haibe-Kains, C Desmedt, C Sotiriou, G Bontempi.
Bioinformatics, 2008 Jul 19; 24(19). PMID: 18635567    Free PMC article.
Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.
Maggie C U Cheang, David Voduc, +5 authors, Torsten O Nielsen.
Clin Cancer Res, 2008 Mar 05; 14(5). PMID: 18316557
Highly Cited.
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy.
Robin M Hallett, Gregory Pond, John A Hassell.
BMC Med Genomics, 2012 May 15; 5. PMID: 22578285    Free PMC article.
A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions.
Jeff C Liu, Sean E Egan, Eldad Zacksenhaus.
Oncotarget, 2013 Aug 16; 4(8). PMID: 23945331    Free PMC article.
Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.
Ning Qing Liu, Christoph Stingl, +15 authors, Arzu Umar.
J Natl Cancer Inst, 2014 Jan 09; 106(2). PMID: 24399849    Free PMC article.
Breast tumor subgroups reveal diverse clinical prognostic power.
Zhaoqi Liu, Xiang-Sun Zhang, Shihua Zhang.
Sci Rep, 2014 Feb 07; 4. PMID: 24499868    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response.
Ning Qing Liu, Tommaso De Marchi, +13 authors, Arzu Umar.
Mol Cell Proteomics, 2014 Apr 20; 13(7). PMID: 24742827    Free PMC article.
Mammary glands exhibit molecular laterality and undergo left-right asymmetric ductal epithelial growth in MMTV-cNeu mice.
J P Robichaux, R M Hallett, +2 authors, A F Ramsdell.
Oncogene, 2014 Jun 10; 34(15). PMID: 24909172    Free PMC article.
A prognostic model of triple-negative breast cancer based on miR-27b-3p and node status.
Songjie Shen, Qiang Sun, +5 authors, Yidong Zhou.
PLoS One, 2014 Jun 20; 9(6). PMID: 24945253    Free PMC article.
Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.
Jessica L Ouderkirk, Mira Krendel.
Cytoskeleton (Hoboken), 2014 Aug 05; 71(8). PMID: 25087729    Free PMC article.
A program to identify prognostic and predictive gene signatures.
Sam D Chorlton, Robin M Hallett, John A Hassell.
BMC Res Notes, 2014 Aug 20; 7. PMID: 25135081    Free PMC article.
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.
Jeff C Liu, Veronique Voisin, +10 authors, Eldad Zacksenhaus.
EMBO Mol Med, 2014 Oct 22; 6(12). PMID: 25330770    Free PMC article.
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients.
Robin M Hallett, Tracy Chew.
BMC Musculoskelet Disord, 2014 Dec 21; 15. PMID: 25526985    Free PMC article.
Identification and evaluation of network modules for the prognosis of basal-like breast cancer.
Robin M Hallett, Jessica G Cockburn, +3 authors, Anita Bane.
Oncotarget, 2015 May 21; 6(19). PMID: 25991675    Free PMC article.
Association of Protein Translation and Extracellular Matrix Gene Sets with Breast Cancer Metastasis: Findings Uncovered on Analysis of Multiple Publicly Available Datasets Using Individual Patient Data Approach.
Nilotpal Chowdhury, Shantanu Sapru.
PLoS One, 2015 Jun 17; 10(6). PMID: 26080057    Free PMC article.
LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells.
N Yokdang, J Hatakeyama, +8 authors, C Sweeney.
Oncogene, 2015 Sep 22; 35(22). PMID: 26387542    Free PMC article.
Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.
Jessica L Ouderkirk-Pecone, Gregory J Goreczny, +3 authors, Mira Krendel.
Oncotarget, 2016 Jun 23; 7(29). PMID: 27329840    Free PMC article.
The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures.
Jessica G Cockburn, Robin M Hallett, +5 authors, Anita Bane.
BMC Cancer, 2016 Jul 30; 16. PMID: 27469239    Free PMC article.
Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.
Robin M Hallett, Alex B K Seong, David R Kaplan, Meredith S Irwin.
Mol Oncol, 2016 Sep 08; 10(9). PMID: 27599694    Free PMC article.
Basal-like breast cancer: molecular profiles, clinical features and survival outcomes.
Heloisa H Milioli, Inna Tishchenko, +2 authors, Pablo Moscato.
BMC Med Genomics, 2017 Mar 30; 10(1). PMID: 28351365    Free PMC article.
Identification of cell proliferation, immune response and cell migration as critical pathways in a prognostic signature for HER2+:ERα- breast cancer.
Jeffrey C Liu, Miriam Zacksenhouse, +2 authors, Eldad Zacksenhaus.
PLoS One, 2017 Jun 21; 12(6). PMID: 28632792    Free PMC article.
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Brian M Kennedy, Randall E Harris.
Inflammopharmacology, 2018 May 08;. PMID: 29736687
Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer.
Bianca Kovac, Tomi P Mäkelä, Tea Vallenius.
PLoS One, 2018 May 10; 13(5). PMID: 29742177    Free PMC article.
Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.
D Dvornikov, M A Schneider, +14 authors, U Klingmüller.
Sci Rep, 2018 Jun 24; 8(1). PMID: 29934580    Free PMC article.
Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.
Gaofeng Xiong, Rachel L Stewart, +6 authors, Ren Xu.
Nat Commun, 2018 Oct 28; 9(1). PMID: 30367042    Free PMC article.
Highly Cited.
BMI1 is a therapeutic target in recurrent medulloblastoma.
David Bakhshinyan, Chitra Venugopal, +35 authors, Sheila K Singh.
Oncogene, 2018 Oct 24; 38(10). PMID: 30348991
Long-Tailed Unconventional Class I Myosins in Health and Disease.
A Navinés-Ferrer, M Martín.
Int J Mol Sci, 2020 Apr 11; 21(7). PMID: 32272642    Free PMC article.
Cytoskeletal Remodeling in Cancer.
Jaya Aseervatham.
Biology (Basel), 2020 Nov 12; 9(11). PMID: 33171868    Free PMC article.
Dogs as a Model for Cancer.
Heather L Gardner, Joelle M Fenger, Cheryl A London.
Annu Rev Anim Biosci, 2015 Nov 14; 4. PMID: 26566160    Free PMC article.
Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes.
Yage Zhang, Fakun Cao, +4 authors, Cheng-Han Yu.
Mol Biol Cell, 2019 Jan 03; 30(5). PMID: 30601698    Free PMC article.
Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling.
Chih-Ling Chung, Shun-Ban Tai, +2 authors, Chun-Lin Chen.
Int J Mol Sci, 2019 Aug 15; 20(16). PMID: 31408934    Free PMC article.
A 23-gene prognostic classifier for prediction of recurrence and survival for Asian breast cancer patients.
Ting-Hao Chen, Jian-Ying Chiu, Kuan-Hui Shih.
Biosci Rep, 2020 Nov 24; 40(12). PMID: 33226082    Free PMC article.