Journal Article
. 2012 Apr; 486(7403):346-52.
doi: 10.1038/nature10983.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Christina Curtis 1 Sohrab P Shah  Suet-Feung Chin  Gulisa Turashvili  Oscar M Rueda  Mark J Dunning  Doug Speed  Andy G Lynch  Shamith Samarajiwa  Yinyin Yuan  Stefan Gräf  Gavin Ha  Gholamreza Haffari  Ali Bashashati  Roslin Russell  Steven McKinney  METABRIC Group  Anita Langerød  Andrew Green  Elena Provenzano  Gordon Wishart  Sarah Pinder  Peter Watson  Florian Markowetz  Leigh Murphy  Ian Ellis  Arnie Purushotham  Anne-Lise Børresen-Dale  James D Brenton  Simon Tavaré  Carlos Caldas  Samuel Aparicio  
Affiliations
  • PMID: 22522925
  •     29 References
  •     2181 citations

Abstract

The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in ~40% of genes, with the landscape dominated by cis- and trans-acting CNAs. By delineating expression outlier genes driven in cis by CNAs, we identified putative cancer genes, including deletions in PPP2R2A, MTAP and MAP2K4. Unsupervised analysis of paired DNA–RNA profiles revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort. These include a high-risk, oestrogen-receptor-positive 11q13/14 cis-acting subgroup and a favourable prognosis subgroup devoid of CNAs. Trans-acting aberration hotspots were found to modulate subgroup-specific gene networks, including a TCR deletion-mediated adaptive immune response in the ‘CNA-devoid’ subgroup and a basal-specific chromosome 5 deletion-associated mitotic network. Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome.

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A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.
Stina Mui Singel, Crystal Cornelius, +4 authors, Jerry W Shay.
Clin Cancer Res, 2013 Mar 13; 19(8). PMID: 23479679    Free PMC article.
An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas.
Priscila Daniele Ramos Cirilo, Fábio Albuquerque Marchi, +5 authors, Silvia Regina Rogatto.
PLoS One, 2013 Mar 14; 8(3). PMID: 23483937    Free PMC article.
CancerDR: cancer drug resistance database.
Rahul Kumar, Kumardeep Chaudhary, +5 authors, Gajendra P S Raghava.
Sci Rep, 2013 Mar 15; 3. PMID: 23486013    Free PMC article.
8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.
Alain Beck, Paul J Carter, +5 authors, Robert Mabry.
MAbs, 2013 Mar 16; 5(3). PMID: 23493119    Free PMC article.
Extracellular vesicles - biomarkers and effectors of the cellular interactome in cancer.
Janusz Rak.
Front Pharmacol, 2013 Mar 20; 4. PMID: 23508692    Free PMC article.
Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer.
Jennifer F Knight, Robert Lesurf, +15 authors, Morag Park.
Proc Natl Acad Sci U S A, 2013 Mar 20; 110(14). PMID: 23509284    Free PMC article.
Association of single nucleotide polymorphisms in Wnt signaling pathway genes with breast cancer in Saudi patients.
Mohammad Saud Alanazi, Narasimha Reddy Parine, +3 authors, Zahid Khan.
PLoS One, 2013 Mar 22; 8(3). PMID: 23516639    Free PMC article.
Genetic susceptibility to triple-negative breast cancer.
Kristen N Stevens, Celine M Vachon, Fergus J Couch.
Cancer Res, 2013 Mar 29; 73(7). PMID: 23536562    Free PMC article.
Highly Cited. Review.
Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction.
Gerald Quon, Syed Haider, +3 authors, Quaid Morris.
Genome Med, 2013 Mar 30; 5(3). PMID: 23537167    Free PMC article.
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
Fergus J Couch, Xianshu Wang, +267 authors, CIMBA.
PLoS Genet, 2013 Apr 02; 9(3). PMID: 23544013    Free PMC article.
Highly Cited.
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.
Patrick C O Leary, Sarah A Penny, +12 authors, William M Gallagher.
BMC Cancer, 2013 Apr 04; 13. PMID: 23547718    Free PMC article.
The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells.
Javier A Menendez, Jorge Joven, +7 authors, Alejandro Vazquez-Martin.
Cell Cycle, 2013 Apr 04; 12(8). PMID: 23549172    Free PMC article.
Highly Cited.
The complex genetic landscape of familial breast cancer.
Lorenzo Melchor, Javier Benítez.
Hum Genet, 2013 Apr 05; 132(8). PMID: 23552954
Review.
Genome evolution during progression to breast cancer.
Daniel E Newburger, Dorna Kashef-Haghighi, +10 authors, Arend Sidow.
Genome Res, 2013 Apr 10; 23(7). PMID: 23568837    Free PMC article.
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.
Luis E Arias-Romero, Olga Villamar-Cruz, +2 authors, Jonathan Chernoff.
Cancer Res, 2013 Apr 12; 73(12). PMID: 23576562    Free PMC article.
Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer.
Stefano Volinia, Carlo M Croce.
Proc Natl Acad Sci U S A, 2013 Apr 17; 110(18). PMID: 23589849    Free PMC article.
Highly Cited.
A self-updating road map of The Cancer Genome Atlas.
David E Robbins, Alexander Grüneberg, +2 authors, Jonas S Almeida.
Bioinformatics, 2013 Apr 19; 29(10). PMID: 23595662    Free PMC article.
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Adam A Margolin, Erhan Bilal, +27 authors, Anne-Lise Børresen-Dale.
Sci Transl Med, 2013 Apr 19; 5(181). PMID: 23596205    Free PMC article.
RNA sequencing of cancer reveals novel splicing alterations.
Jeyanthy Eswaran, Anelia Horvath, +9 authors, Rakesh Kumar.
Sci Rep, 2013 Apr 23; 3. PMID: 23604310    Free PMC article.
Highly Cited.
Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
Zachary C Hartman, Graham M Poage, +8 authors, Powel H Brown.
Cancer Res, 2013 May 02; 73(11). PMID: 23633491    Free PMC article.
Highly Cited.
PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in Cancer.
Alison Kurimchak, Xavier Graña.
Genes Cancer, 2013 May 02; 3(11-12). PMID: 23634261    Free PMC article.
Protein phosphatase 2A: a target for anticancer therapy.
Danilo Perrotti, Paolo Neviani.
Lancet Oncol, 2013 May 04; 14(6). PMID: 23639323    Free PMC article.
Highly Cited. Review.
The shaping and functional consequences of the microRNA landscape in breast cancer.
Heidi Dvinge, Anna Git, +14 authors, Carlos Caldas.
Nature, 2013 May 07; 497(7449). PMID: 23644459
Highly Cited.
Improving breast cancer survival analysis through competition-based multidimensional modeling.
Erhan Bilal, Janusz Dutkowski, +21 authors, Adam A Margolin.
PLoS Comput Biol, 2013 May 15; 9(5). PMID: 23671412    Free PMC article.
Circulating tumour cells and cell-free DNA as tools for managing breast cancer.
Leticia De Mattos-Arruda, Javier Cortes, +4 authors, Joan Seoane.
Nat Rev Clin Oncol, 2013 May 29; 10(7). PMID: 23712187
Review.
Claudin 1 expression in basal-like breast cancer is related to patient age.
Anne A Blanchard, Xiuli Ma, +6 authors, Yvonne Myal.
BMC Cancer, 2013 Jun 01; 13. PMID: 23721519    Free PMC article.
Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants.
H Zubair, H Y Khan, +5 authors, S M Hadi.
Cell Death Dis, 2013 Jun 08; 4. PMID: 23744360    Free PMC article.
An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
I Garcia-Murillas, R Sharpe, +4 authors, N C Turner.
Oncogene, 2013 Jun 12; 33(19). PMID: 23752180    Free PMC article.
Integrative analysis of cancer-related signaling pathways.
Thomas Kessler, Hendrik Hache, Christoph Wierling.
Front Physiol, 2013 Jun 14; 4. PMID: 23760067    Free PMC article.
Detection of cancer before distant metastasis.
Frank A W Coumans, Sabine Siesling, Leon W M M Terstappen.
BMC Cancer, 2013 Jun 15; 13. PMID: 23763955    Free PMC article.
Translating next generation sequencing to practice: opportunities and necessary steps.
Sitharthan Kamalakaran, Vinay Varadan, +5 authors, Lyndsay N Harris.
Mol Oncol, 2013 Jun 19; 7(4). PMID: 23769412    Free PMC article.
Review.
Video Q&A: molecular profiling of breast cancer.
Carlos Caldas.
BMC Med, 2013 Jun 27; 11. PMID: 23800190    Free PMC article.
Genetic heterogeneity in breast cancer: the road to personalized medicine?
Richard D Baird, Carlos Caldas.
BMC Med, 2013 Jun 27; 11. PMID: 23800221    Free PMC article.
Review.
BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome.
Stephen F Madden, Colin Clarke, +5 authors, William M Gallagher.
Breast Cancer Res, 2013 Jul 04; 15(4). PMID: 23820017    Free PMC article.
Highly Cited.
The locus of microRNA-10b: a critical target for breast cancer insurgence and dissemination.
Francesca Biagioni, Noa Bossel Ben-Moshe, +3 authors, Giovanni Blandino.
Cell Cycle, 2013 Jul 11; 12(15). PMID: 23839045    Free PMC article.
Review.
Crowdsourced contest identifies best-in-class breast cancer prognostic.
Michael Eisenstein.
Nat Biotechnol, 2013 Jul 11; 31(7). PMID: 23839130
Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA.
Malwina Niemczyk, Yoko Ito, +6 authors, Adele Murrell.
Am J Hum Genet, 2013 Jul 23; 93(2). PMID: 23871723    Free PMC article.
Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.
Gordana Maric, April An Rose, Matthew G Annis, Peter M Siegel.
Onco Targets Ther, 2013 Jul 23; 6. PMID: 23874106    Free PMC article.
Genes dysregulated to different extent or oppositely in estrogen receptor-positive and estrogen receptor-negative breast cancers.
Xianxiao Zhou, Tongwei Shi, +6 authors, Zheng Guo.
PLoS One, 2013 Jul 23; 8(7). PMID: 23875016    Free PMC article.
FiloDetect: automatic detection of filopodia from fluorescence microscopy images.
Sharmin Nilufar, Anne A Morrow, Jonathan M Lee, Theodore J Perkins.
BMC Syst Biol, 2013 Jul 25; 7. PMID: 23880086    Free PMC article.
Luminal breast cancer: from biology to treatment.
Michail Ignatiadis, Christos Sotiriou.
Nat Rev Clin Oncol, 2013 Jul 25; 10(9). PMID: 23881035
Review.
Novel insights into breast cancer genetic variance through RNA sequencing.
Anelia Horvath, Suresh Babu Pakala, +10 authors, Rakesh Kumar.
Sci Rep, 2013 Jul 26; 3. PMID: 23884293    Free PMC article.
Profiling the immune stromal interface in breast cancer and its potential for clinical impact.
Sheeba Irshad, Anita Grigoriadis, +2 authors, Andrew Tutt.
Breast Care (Basel), 2013 Aug 02; 7(4). PMID: 23904829    Free PMC article.
The genomic map of breast cancer: which roads lead to better targeted therapies?
Justin M Balko, Thomas P Stricker, Carlos L Arteaga.
Breast Cancer Res, 2013 Aug 03; 15(4). PMID: 23905624    Free PMC article.
Review.
Assignment of tumor subtype by genomic testing and pathologic-based approximations: implications on patient's management and therapy selection.
A Romero, A Prat, +9 authors, M Martín.
Clin Transl Oncol, 2013 Aug 03; 16(4). PMID: 23907291
A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences.
Lorenza Mittempergher, Mahasti Saghatchian, +9 authors, Laura J van't Veer.
Mol Oncol, 2013 Aug 06; 7(5). PMID: 23910573    Free PMC article.
Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance.
Claire Jackson, David Browell, Hannah Gautrey, Alison Tyson-Capper.
Int J Cell Biol, 2013 Aug 13; 2013. PMID: 23935627    Free PMC article.
Simple and versatile molecular method of copy-number measurement using cloned competitors.
Hyun-Kyoung Kim, Hai-Li Hwang, +12 authors, Kyeong-Man Hong.
PLoS One, 2013 Aug 13; 8(7). PMID: 23936009    Free PMC article.
Dual-color fluorescence in situ hybridization reveals an association of chromosome 8q22 but not 8p21 imbalance with high grade invasive breast carcinoma.
Logan C Walker, Margaret McDonald, +3 authors, Christine M Morris.
PLoS One, 2013 Aug 13; 8(7). PMID: 23936250    Free PMC article.
Personalizing health care: feasibility and future implications.
Brian Godman, Alexander E Finlayson, +42 authors, Lars L Gustafsson.
BMC Med, 2013 Aug 15; 11. PMID: 23941275    Free PMC article.
Review.
Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study.
Yan Lin, Changjun Wang, +5 authors, Qiang Sun.
J Exp Clin Cancer Res, 2013 Aug 15; 32(1). PMID: 23941600    Free PMC article.
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.
Fabio Petrocca, Gabriel Altschuler, +7 authors, Judy Lieberman.
Cancer Cell, 2013 Aug 21; 24(2). PMID: 23948298    Free PMC article.
Highly Cited.
Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer.
Pei-Yin Hsu, Hang-Kai Hsu, +16 authors, Tim H-M Huang.
Cancer Cell, 2013 Aug 21; 24(2). PMID: 23948299    Free PMC article.
Revealing targeted therapeutic opportunities in triple-negative breast cancers: a new strategy.
Graham M Poage, Zachary C Hartman, Powel H Brown.
Cell Cycle, 2013 Aug 24; 12(17). PMID: 23966168    Free PMC article.
Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis.
J Chuck Harrell, Adam D Pfefferle, +7 authors, Charles M Perou.
Clin Exp Metastasis, 2013 Aug 27; 31(1). PMID: 23975155    Free PMC article.
Neoadjuvant therapy in operable breast cancer: application to triple negative breast cancer.
Foluso O Ademuyiwa, Matthew J Ellis, Cynthia X Ma.
J Oncol, 2013 Aug 29; 2013. PMID: 23983689    Free PMC article.
Bayesian consensus clustering.
Eric F Lock, David B Dunson.
Bioinformatics, 2013 Aug 31; 29(20). PMID: 23990412    Free PMC article.
Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling.
Xi Zhang, Xin Mu, +4 authors, Kunwei Shen.
PLoS One, 2013 Aug 31; 8(8). PMID: 23991038    Free PMC article.
Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells.
Chun Chen, William T Baumann, Robert Clarke, John J Tyson.
FEBS Lett, 2013 Sep 03; 587(20). PMID: 23994522    Free PMC article.
Selective nucleic acid removal via exclusion (SNARE): capturing mRNA and DNA from a single sample.
Lindsay Strotman, Rachel O'Connell, +4 authors, David J Beebe.
Anal Chem, 2013 Sep 11; 85(20). PMID: 24016179    Free PMC article.
Precise inference of copy number alterations in tumor samples from SNP arrays.
Gary K Chen, Xiao Chang, Christina Curtis, Kai Wang.
Bioinformatics, 2013 Sep 12; 29(23). PMID: 24021380    Free PMC article.
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.
Sara Koenig McLaughlin, Sarah Naomi Olsen, +8 authors, Karen Cichowski.
Cancer Cell, 2013 Sep 14; 24(3). PMID: 24029233    Free PMC article.
Ontology-aware classification of tissue and cell-type signals in gene expression profiles across platforms and technologies.
Young-suk Lee, Arjun Krishnan, Qian Zhu, Olga G Troyanskaya.
Bioinformatics, 2013 Sep 17; 29(23). PMID: 24037214    Free PMC article.
Master regulators of FGFR2 signalling and breast cancer risk.
Michael N C Fletcher, Mauro A A Castro, +8 authors, Kerstin B Meyer.
Nat Commun, 2013 Sep 18; 4. PMID: 24043118    Free PMC article.
Pathway-based outlier method reveals heterogeneous genomic structure of autism in blood transcriptome.
Malcolm G Campbell, Isaac S Kohane, Sek Won Kong.
BMC Med Genomics, 2013 Sep 26; 6. PMID: 24063311    Free PMC article.
Allogeneic tumor cell vaccines: the promise and limitations in clinical trials.
Sanjay Srivatsan, Jaina M Patel, +4 authors, Periasamy Selvaraj.
Hum Vaccin Immunother, 2013 Sep 26; 10(1). PMID: 24064957    Free PMC article.
Review.
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.
Anchit Khanna, Otto Kauko, +18 authors, Jukka Westermarck.
Cancer Res, 2013 Sep 28; 73(22). PMID: 24072747    Free PMC article.
Mutational analysis of breast cancer: guiding personalized treatments.
Matthew J Ellis.
Breast, 2013 Oct 01; 22 Suppl 2. PMID: 24074785    Free PMC article.
Review.
The mutational landscape of phosphorylation signaling in cancer.
Jüri Reimand, Omar Wagih, Gary D Bader.
Sci Rep, 2013 Oct 04; 3. PMID: 24089029    Free PMC article.
Highly Cited.
PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy.
Yi-Teng Huang, Fei-Fei Li, +6 authors, Hao Zhang.
J Transl Med, 2013 Oct 05; 11. PMID: 24090193    Free PMC article.
Do type 1 receptor tyrosine kinases inform treatment choice? A prospectively planned analysis of the TEAM trial.
J M S Bartlett, C L Brookes, +13 authors, D W Rea.
Br J Cancer, 2013 Oct 05; 109(9). PMID: 24091623    Free PMC article.
The molecular diversity of Luminal A breast tumors.
Giovanni Ciriello, Rileen Sinha, +5 authors, Nikolaus Schultz.
Breast Cancer Res Treat, 2013 Oct 08; 141(3). PMID: 24096568    Free PMC article.
A robust prognostic signature for hormone-positive node-negative breast cancer.
Obi L Griffith, François Pepin, +4 authors, Joe W Gray.
Genome Med, 2013 Oct 12; 5(10). PMID: 24112773    Free PMC article.
Metastatic progression of breast cancer: insights from 50 years of autopsies.
Margaret C Cummings, Peter T Simpson, +9 authors, Sunil R Lakhani.
J Pathol, 2013 Oct 15; 232(1). PMID: 24122263    Free PMC article.
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Willem-Jan Keune, Andrew H Sims, +5 authors, Nullin Divecha.
Cancer Res, 2013 Oct 16; 73(23). PMID: 24127122    Free PMC article.
CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2.
D Bedognetti, T L Spivey, +13 authors, F M Marincola.
Br J Cancer, 2013 Oct 17; 109(9). PMID: 24129241    Free PMC article.
Clinical application of high-throughput genomic technologies for treatment selection in breast cancer.
Aaron R Hansen, Philippe L Bedard.
Breast Cancer Res, 2013 Oct 19; 15(5). PMID: 24135425    Free PMC article.
Review.
Genomics meets proteomics: identifying the culprits in disease.
Hendrik G Stunnenberg, Nina C Hubner.
Hum Genet, 2013 Oct 19; 133(6). PMID: 24135908    Free PMC article.
Review.
Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function.
A S Beltran, L M Graves, P Blancafort.
Oncogene, 2013 Oct 22; 33(39). PMID: 24141779    Free PMC article.
Genomic instability: a stronger prognostic marker than proliferation for early stage luminal breast carcinomas.
Anne Vincent-Salomon, Vanessa Benhamo, +13 authors, Olivier Delattre.
PLoS One, 2013 Oct 22; 8(10). PMID: 24143191    Free PMC article.
Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition.
Muthulakshmi Muthuswami, Vignesh Ramesh, +6 authors, Kumaresan Ganesan.
PLoS One, 2013 Oct 23; 8(10). PMID: 24147022    Free PMC article.
Insulin and IGFs in obesity-related breast cancer.
Valentina Belardi, Emily J Gallagher, Ruslan Novosyadlyy, Derek LeRoith.
J Mammary Gland Biol Neoplasia, 2013 Oct 25; 18(3-4). PMID: 24154546
Review.
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Inga Reynisdottir, Adalgeir Arason, +14 authors, Rosa Bjork Barkardottir.
Cancer Med, 2013 Oct 25; 2(4). PMID: 24156016    Free PMC article.
A pathway-based data integration framework for prediction of disease progression.
José A Seoane, Ian N M Day, Tom R Gaunt, Colin Campbell.
Bioinformatics, 2013 Oct 29; 30(6). PMID: 24162466    Free PMC article.
Molecular fingerprinting catches responders to therapeutic agents.
Genome Biol, 2013 Nov 02; 14(10). PMID: 24176101    Free PMC article.
Modeling precision treatment of breast cancer.
Anneleen Daemen, Obi L Griffith, +24 authors, Joe W Gray.
Genome Biol, 2013 Nov 02; 14(10). PMID: 24176112    Free PMC article.
Highly Cited.
The landscape of candidate driver genes differs between male and female breast cancer.
Ida Johansson, Markus Ringnér, Ingrid Hedenfalk.
PLoS One, 2013 Nov 07; 8(10). PMID: 24194916    Free PMC article.
Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells.
Molly A Taylor, Gangarao Davuluri, +5 authors, Khalid Sossey-Alaoui.
Breast Cancer Res Treat, 2013 Nov 08; 142(2). PMID: 24197660    Free PMC article.
Beyond GWASs: illuminating the dark road from association to function.
Stacey L Edwards, Jonathan Beesley, Juliet D French, Alison M Dunning.
Am J Hum Genet, 2013 Nov 12; 93(5). PMID: 24210251    Free PMC article.
Highly Cited. Review.
A Nonparametric Bayesian Model for Local Clustering with Application to Proteomics.
Juhee Lee, Peter Müller, Yitan Zhu, Yuan Ji.
J Am Stat Assoc, 2013 Nov 14; 108(503). PMID: 24222928    Free PMC article.
An integrated model of the transcriptome of HER2-positive breast cancer.
Krishna R Kalari, Brian M Necela, +19 authors, Edith A Perez.
PLoS One, 2013 Nov 14; 8(11). PMID: 24223926    Free PMC article.
Computational methods for detecting copy number variations in cancer genome using next generation sequencing: principles and challenges.
Biao Liu, Carl D Morrison, +5 authors, Song Liu.
Oncotarget, 2013 Nov 19; 4(11). PMID: 24240121    Free PMC article.
Review.
Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.
Evelin Young, Ze-Yi Zheng, +4 authors, Eric C Chang.
Mol Cell Biol, 2013 Nov 20; 34(3). PMID: 24248599    Free PMC article.
Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus.
Xiaohong Li, Patricia C Galipeau, +12 authors, Brian J Reid.
Cancer Prev Res (Phila), 2013 Nov 21; 7(1). PMID: 24253313    Free PMC article.
Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
Yongqiang Chen, Huijun Wei, Fei Liu, Jun-Lin Guan.
J Biol Chem, 2013 Nov 28; 289(2). PMID: 24275666    Free PMC article.
Genome-scale technology driven advances to research into normal and malignant haematopoiesis.
Berthold Göttgens.
Scientifica (Cairo), 2012 Jan 01; 2012. PMID: 24278696    Free PMC article.
Review.
EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.
Jung-Min Choi, Sushil Devkota, Young Hoon Sung, Han-Woong Lee.
Oncotarget, 2013 Nov 28; 4(12). PMID: 24280371    Free PMC article.
MicroRNAs and triple negative breast cancer.
Elvira D'Ippolito, Marilena V Iorio.
Int J Mol Sci, 2013 Nov 29; 14(11). PMID: 24284394    Free PMC article.
Review.
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.
Kerstin B Meyer, Martin O'Reilly, +200 authors, Douglas F Easton.
Am J Hum Genet, 2013 Dec 03; 93(6). PMID: 24290378    Free PMC article.
Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing.
Milan Radovich, Susan E Clare, +24 authors, Bryan P Schneider.
Breast Cancer Res Treat, 2013 Dec 03; 143(1). PMID: 24292813    Free PMC article.
Evaluation of calling algorithms for array-CGH.
Siddharth Roy, Alison Motsinger Reif.
Front Genet, 2013 Dec 04; 4. PMID: 24298279    Free PMC article.
Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis.
Hojoon Lee, Patrick Flaherty, Hanlee P Ji.
BMC Med Genomics, 2013 Dec 07; 6. PMID: 24308539    Free PMC article.
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.
Jacob J Kennedy, Susan E Abbatiello, +18 authors, Amanda G Paulovich.
Nat Methods, 2013 Dec 10; 11(2). PMID: 24317253    Free PMC article.
Highly Cited.
Evaluation of ultra-deep targeted sequencing for personalized breast cancer care.
Olivier Harismendy, Richard B Schwab, +11 authors, Kelly A Frazer.
Breast Cancer Res, 2013 Dec 12; 15(6). PMID: 24326041    Free PMC article.
Targeting Akt3 signaling in triple-negative breast cancer.
Y Rebecca Chin, Taku Yoshida, +3 authors, Alex Toker.
Cancer Res, 2013 Dec 18; 74(3). PMID: 24335962    Free PMC article.
A gradient boosting algorithm for survival analysis via direct optimization of concordance index.
Yifei Chen, Zhenyu Jia, Dan Mercola, Xiaohui Xie.
Comput Math Methods Med, 2013 Dec 19; 2013. PMID: 24348746    Free PMC article.
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
Unjin Lee, Casey Frankenberger, +6 authors, Marsha Rich Rosner.
PLoS One, 2013 Dec 19; 8(12). PMID: 24349199    Free PMC article.
Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression.
R E Airley, P McHugh, +6 authors, A L Harris.
Br J Cancer, 2013 Dec 25; 110(3). PMID: 24366300    Free PMC article.
Keeping an open mind: highlights and controversies of the breast cancer stem cell theory.
Mansi Shah, Cinzia Allegrucci.
Breast Cancer (Dove Med Press), 2012 Jan 01; 4. PMID: 24367202    Free PMC article.
Review.
Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry.
Christine B Ambrosone, Allyson C Young, +10 authors, Michael J Higgins.
Oncotarget, 2013 Dec 26; 5(1). PMID: 24368439    Free PMC article.
Identification of metastasis-associated genes in colorectal cancer through an integrated genomic and transcriptomic analysis.
Xiaobo Li, Sihua Peng.
Chin J Cancer Res, 2014 Jan 05; 25(6). PMID: 24385689    Free PMC article.
Determination of HER2 amplification status on tumour DNA by digital PCR.
Isaac Garcia-Murillas, Maryou Lambros, Nicholas C Turner.
PLoS One, 2014 Jan 05; 8(12). PMID: 24386193    Free PMC article.
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
David A Quigley, Elisa Fiorito, +12 authors, Vessela Kristensen.
Mol Oncol, 2014 Jan 07; 8(2). PMID: 24388359    Free PMC article.
The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming.
Stéphanie Cunha, Yi-Chun Lin, +5 authors, Alana L Welm.
Cell Rep, 2014 Jan 07; 6(1). PMID: 24388747    Free PMC article.
DACH1: its role as a classifier of long term good prognosis in luminal breast cancer.
Desmond G Powe, Gopal Krishna R Dhondalay, +5 authors, Graham R Ball.
PLoS One, 2014 Jan 07; 9(1). PMID: 24392136    Free PMC article.
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Josh Neman, John Termini, +7 authors, Rahul Jandial.
Proc Natl Acad Sci U S A, 2014 Jan 08; 111(3). PMID: 24395782    Free PMC article.
Highly Cited.
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.
Thalia A Farazi, Jelle J Ten Hoeve, +5 authors, Lodewyk F A Wessels.
Genome Biol, 2014 Jan 09; 15(1). PMID: 24398324    Free PMC article.
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Anna Tessari, Dario Palmieri, Serena Di Cosimo.
Pharmgenomics Pers Med, 2014 Jan 10; 7. PMID: 24403841    Free PMC article.
Review.
Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study.
David J Klinke.
PLoS Comput Biol, 2014 Jan 16; 10(1). PMID: 24426833    Free PMC article.
Rapid learning for precision oncology.
Jeff Shrager, Jay M Tenenbaum.
Nat Rev Clin Oncol, 2014 Jan 22; 11(2). PMID: 24445514
Review.
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Maria T Grinde, Nirma Skrbo, +11 authors, Ingrid S Gribbestad.
Breast Cancer Res, 2014 Jan 23; 16(1). PMID: 24447408    Free PMC article.
DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts.
Tarek M A Abdel-Fatah, Roslin Russell, +9 authors, Srinivasan Madhusudan.
Mol Oncol, 2014 Jan 28; 8(3). PMID: 24462520    Free PMC article.
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.
Sandro Santagata, Ankita Thakkar, +13 authors, Tan A Ince.
J Clin Invest, 2014 Jan 28; 124(2). PMID: 24463450    Free PMC article.
Highly Cited.
Similarity network fusion for aggregating data types on a genomic scale.
Bo Wang, Aziz M Mezlini, +5 authors, Anna Goldenberg.
Nat Methods, 2014 Jan 28; 11(3). PMID: 24464287
Highly Cited.
Molecular tests as prognostic factors in breast cancer.
Marc J van de Vijver.
Virchows Arch, 2014 Feb 04; 464(3). PMID: 24487789
Review.
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.
Jae-Hwan Kim, Amrish Sharma, +5 authors, Min Gyu Lee.
Cancer Res, 2014 Feb 05; 74(6). PMID: 24491801    Free PMC article.
Highly Cited.
Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine.
Linping Hu, Kun Ru, +6 authors, Weimin Miao.
Biomark Res, 2014 Feb 07; 2(1). PMID: 24499728    Free PMC article.
Breast tumor subgroups reveal diverse clinical prognostic power.
Zhaoqi Liu, Xiang-Sun Zhang, Shihua Zhang.
Sci Rep, 2014 Feb 07; 4. PMID: 24499868    Free PMC article.
Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer.
Zeynep Madak-Erdogan, Rosa Ventrella, Luke Petry, Benita S Katzenellenbogen.
Mol Cancer Res, 2014 Feb 08; 12(5). PMID: 24505128    Free PMC article.
Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity.
Denise M Wolf, Marc E Lenburg, +2 authors, Laura J van 't Veer.
PLoS One, 2014 Feb 12; 9(2). PMID: 24516633    Free PMC article.
Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.
Erica B Schleifman, Rupal Desai, +13 authors, Mark R Lackner.
PLoS One, 2014 Feb 13; 9(2). PMID: 24520381    Free PMC article.
High-throughput gene expression and mutation profiling: current methods and future perspectives.
Thomas Karn.
Breast Care (Basel), 2014 Feb 20; 8(6). PMID: 24550747    Free PMC article.
Review.
A new method for predicting patient survivorship using efficient bayesian network learning.
Xia Jiang, Diyang Xue, +2 authors, Richard Neapolitan.
Cancer Inform, 2014 Feb 22; 13. PMID: 24558297    Free PMC article.
The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.
Emmanuelle Viré, Christina Curtis, +9 authors, Tony Kouzarides.
Mol Cell, 2014 Mar 04; 53(5). PMID: 24582497    Free PMC article.
The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response.
Mathew J Garnett, Ultan McDermott.
Curr Opin Genet Dev, 2014 Mar 13; 24. PMID: 24607840    Free PMC article.
Review.
A framework for biobank sustainability.
Peter H Watson, Sara Y Nussbeck, +15 authors, Brent Schacter.
Biopreserv Biobank, 2014 Mar 14; 12(1). PMID: 24620771    Free PMC article.
A microRNA signature associated with early recurrence in breast cancer.
Luis G Pérez-Rivas, José M Jerez, +9 authors, José Lozano.
PLoS One, 2014 Mar 19; 9(3). PMID: 24632820    Free PMC article.
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
Xi Zhao, Einar Andreas Rødland, +5 authors, Anne-Lise Børresen-Dale.
BMC Cancer, 2014 Mar 22; 14. PMID: 24645668    Free PMC article.
Multidrug-resistant breast cancer: current perspectives.
Heather L Martin, Laura Smith, Darren C Tomlinson.
Breast Cancer (Dove Med Press), 2014 Mar 22; 6. PMID: 24648765    Free PMC article.
Review.
Information content and analysis methods for multi-modal high-throughput biomedical data.
Bisakha Ray, Mikael Henaff, +6 authors, Alexander Statnikov.
Sci Rep, 2014 Mar 22; 4. PMID: 24651673    Free PMC article.
Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in Cancer.
Sven Bilke, Yevgeniy Gindin.
Front Oncol, 2014 Mar 22; 4. PMID: 24653980    Free PMC article.
Seven In Absentia Homolog 2 (SIAH2) downregulation is associated with tamoxifen resistance in MCF-7 breast cancer cells.
Rodrigo B Interiano, Jun Yang, Adrian L Harris, Andrew M Davidoff.
J Surg Res, 2014 Mar 25; 190(1). PMID: 24656476    Free PMC article.
Tug of war between survival and death: exploring ATM function in cancer.
Venturina Stagni, Veronica Oropallo, +3 authors, Daniela Barilà.
Int J Mol Sci, 2014 Apr 01; 15(4). PMID: 24681585    Free PMC article.
Review.
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Clare C Davies, Emma Harvey, +5 authors, Cathy Tournier.
Cancer Res, 2014 Apr 10; 74(12). PMID: 24713432    Free PMC article.
Radiotherapy issues in elderly breast cancer patients.
Ian Kunkler.
Breast Care (Basel), 2012 Dec 01; 7(6). PMID: 24715826    Free PMC article.
Review.
Distinct Copy Number, Coding Sequence, and Locus Methylation Patterns Underlie Rhg1-Mediated Soybean Resistance to Soybean Cyst Nematode.
David E Cook, Adam M Bayless, +4 authors, Andrew F Bent.
Plant Physiol, 2014 Apr 16; 165(2). PMID: 24733883    Free PMC article.
Patterns and Biologic Features of p53 Mutation Types in Korean Breast Cancer Patients.
Hyung Won Kim, Hak Min Lee, +3 authors, Joon Jeong.
J Breast Cancer, 2014 Apr 20; 17(1). PMID: 24744791    Free PMC article.
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.
F Al-Ejeh, P T Simpson, +12 authors, K K Khanna.
Oncogenesis, 2014 Apr 23; 3. PMID: 24752235    Free PMC article.
MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer.
Aoife Ward, Kirti Shukla, +4 authors, Stefan Wiemann.
J Pathol, 2014 Apr 23; 233(4). PMID: 24752803    Free PMC article.
Principles and methods of integrative genomic analyses in cancer.
Vessela N Kristensen, Ole Christian Lingjærde, +3 authors, Anne-Lise Børresen-Dale.
Nat Rev Cancer, 2014 Apr 25; 14(5). PMID: 24759209
Highly Cited. Review.
Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
Fares Al-Ejeh, Mariska Miranda, +10 authors, Kum Kum Khanna.
Oncotarget, 2014 Apr 26; 5(10). PMID: 24762669    Free PMC article.
JAK2 expression is associated with tumor-infiltrating lymphocytes and improved breast cancer outcomes: implications for evaluating JAK2 inhibitors.
Chris P Miller, Jason D Thorpe, +7 authors, C Anthony Blau.
Cancer Immunol Res, 2014 Apr 26; 2(4). PMID: 24764577    Free PMC article.
SIP1/NHERF2 enhances estrogen receptor alpha transactivation in breast cancer cells.
Ivan Meneses-Morales, Angeles C Tecalco-Cruz, +10 authors, Alfonso León-Del-Río.
Nucleic Acids Res, 2014 Apr 29; 42(11). PMID: 24771346    Free PMC article.
Tracking and evaluating molecular tumor markers with cancer registry data: HER2 and breast cancer.
William F Anderson, Philip S Rosenberg, Hormuzd A Katki.
J Natl Cancer Inst, 2014 Apr 30; 106(5). PMID: 24777110    Free PMC article.
Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.
Chin-Ann Johnny Ong, Nicholas B Shannon, +10 authors, Rebecca C Fitzgerald.
J Natl Cancer Inst, 2014 Apr 30; 106(5). PMID: 24777112    Free PMC article.
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
Stina M Singel, Crystal Cornelius, +11 authors, Jerry W Shay.
Neoplasia, 2014 May 03; 16(3). PMID: 24784001    Free PMC article.
Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression.
Priya Sudarsanam, Barak A Cohen.
PLoS Genet, 2014 May 03; 10(5). PMID: 24784239    Free PMC article.
Breast cancer prognosis predicted by nuclear receptor-coregulator networks.
Tram B Doan, Natalie A Eriksson, +9 authors, Christine L Clarke.
Mol Oncol, 2014 May 03; 8(5). PMID: 24785096    Free PMC article.
A data standard for sourcing fit-for-purpose biological samples in an integrated virtual network of biobanks.
Philip R Quinlan, Gita Mistry, +2 authors, Confederation of Cancer Biobanks (CCB) Working Group 3.
Biopreserv Biobank, 2014 May 03; 12(3). PMID: 24785371    Free PMC article.
Triple-negative breast cancer: bridging the gap from cancer genomics to predictive biomarkers.
S Lindsey Davis, S Gail Eckhardt, John J Tentler, Jennifer R Diamond.
Ther Adv Med Oncol, 2014 May 03; 6(3). PMID: 24790649    Free PMC article.
Review.
A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.
Chao Liu, Sriganesh Srihari, +4 authors, Kum Kum Khanna.
Nucleic Acids Res, 2014 May 06; 42(10). PMID: 24792170    Free PMC article.
Review.
Big data bioinformatics.
Casey S Greene, Jie Tan, +2 authors, Chao Cheng.
J Cell Physiol, 2014 May 07; 229(12). PMID: 24799088    Free PMC article.
Review.
Rad51 supports triple negative breast cancer metastasis.
Adrian P Wiegmans, Fares Al-Ejeh, +9 authors, Kum Kum Khanna.
Oncotarget, 2014 May 09; 5(10). PMID: 24811120    Free PMC article.
Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth.
Samina Alam, Brian S Bowser, +2 authors, Craig Meyers.
Cancer Biol Ther, 2014 May 20; 15(8). PMID: 24834917    Free PMC article.
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.
Yubao Wang, Young-Mi Lee, +15 authors, Jean J Zhao.
Elife, 2014 May 23; 3. PMID: 24844244    Free PMC article.
Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors.
Steven T Sizemore, Gina M Sizemore, +6 authors, Ruth A Keri.
Breast Cancer Res Treat, 2014 May 23; 146(1). PMID: 24847890    Free PMC article.
NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.
Filippos Kottakis, Parthena Foltopoulou, +10 authors, Philip N Tsichlis.
Cancer Res, 2014 May 24; 74(14). PMID: 24853546    Free PMC article.
The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
Peter P Ruvolo, Vivian R Ruvolo, +14 authors, Michael Andreeff.
Biochim Biophys Acta, 2014 May 27; 1843(9). PMID: 24858343    Free PMC article.
Molecular classification of breast cancer.
Darina Vuong, Peter T Simpson, +2 authors, Sunil R Lakhani.
Virchows Arch, 2014 Jun 01; 465(1). PMID: 24878755
A community effort to assess and improve drug sensitivity prediction algorithms.
James C Costello, Laura M Heiser, +20 authors, Gustavo Stolovitzky.
Nat Biotechnol, 2014 Jun 02; 32(12). PMID: 24880487    Free PMC article.
Highly Cited.
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
Tarek M A Abdel-Fatah, Roslin Russell, +18 authors, Srinivasan Madhusudan.
Mol Oncol, 2014 Jun 02; 8(7). PMID: 24880630    Free PMC article.
Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells.
Suhn Kyong Rhie, Dennis J Hazelett, +3 authors, Gerhard A Coetzee.
BMC Genomics, 2014 Jun 03; 15. PMID: 24885402    Free PMC article.
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast.
Nadège Gruel, Vanessa Benhamo, +10 authors, Anne Vincent-Salomon.
Breast Cancer Res, 2014 Jun 03; 16(3). PMID: 24887297    Free PMC article.
A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions.
Alayne L Brunner, Jun Li, +6 authors, Robert B West.
Genome Biol, 2014 Jun 03; 15(5). PMID: 24887547    Free PMC article.
Mammary stem cells and the differentiation hierarchy: current status and perspectives.
Jane E Visvader, John Stingl.
Genes Dev, 2014 Jun 04; 28(11). PMID: 24888586    Free PMC article.
Highly Cited. Review.
An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.
Misako Sato, Mitsutaka Kadota, +11 authors, Lalage M Wakefield.
Breast Cancer Res, 2014 Jun 04; 16(3). PMID: 24890385    Free PMC article.
Integrative analysis of transcriptional regulatory network and copy number variation in intrahepatic cholangiocarcinoma.
Ling Li, Baofeng Lian, +6 authors, Lu Xie.
PLoS One, 2014 Jun 05; 9(6). PMID: 24897108    Free PMC article.
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.
J Sternemalm, H G Russnes, +6 authors, S Patzke.
Br J Cancer, 2014 Jun 06; 111(2). PMID: 24901235    Free PMC article.
Ensemble analyses improve signatures of tumour hypoxia and reveal inter-platform differences.
Natalie S Fox, Maud H W Starmans, +2 authors, Paul C Boutros.
BMC Bioinformatics, 2014 Jun 07; 15. PMID: 24902696    Free PMC article.
Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells.
Stephan Duss, Heike Brinkhaus, +4 authors, Mohamed Bentires-Alj.
Breast Cancer Res, 2014 Jun 12; 16(3). PMID: 24916766    Free PMC article.
RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.
L A Walsh, D M Roy, +8 authors, T A Chan.
Oncogene, 2014 Jun 17; 34(17). PMID: 24931164    Free PMC article.
Modeling the altered expression levels of genes on signaling pathways in tumors as causal bayesian networks.
Richard Neapolitan, Diyang Xue, Xia Jiang.
Cancer Inform, 2014 Jun 17; 13. PMID: 24932098    Free PMC article.
JARID1B is a luminal lineage-driving oncogene in breast cancer.
Shoji Yamamoto, Zhenhua Wu, +19 authors, Kornelia Polyak.
Cancer Cell, 2014 Jun 18; 25(6). PMID: 24937458    Free PMC article.
Highly Cited.
Comparisons of non-Gaussian statistical models in DNA methylation analysis.
Zhanyu Ma, Andrew E Teschendorff, +2 authors, Jun Guo.
Int J Mol Sci, 2014 Jun 18; 15(6). PMID: 24937687    Free PMC article.
MultiBLUP: improved SNP-based prediction for complex traits.
Doug Speed, David J Balding.
Genome Res, 2014 Jun 26; 24(9). PMID: 24963154    Free PMC article.
Highly Cited.
Rare breast cancer subtypes: histological, molecular, and clinical peculiarities.
Maria Vittoria Dieci, Enrico Orvieto, +2 authors, Valentina Guarneri.
Oncologist, 2014 Jun 28; 19(8). PMID: 24969162    Free PMC article.
Therapeutic targeting of integrin αvβ6 in breast cancer.
Kate M Moore, Gareth J Thomas, +25 authors, John F Marshall.
J Natl Cancer Inst, 2014 Jun 30; 106(8). PMID: 24974129    Free PMC article.
Chronic disease prevention in primary care: how and when will genomics impact?
Fiona M Walter, Jon Emery, Hilary Burton.
Br J Gen Pract, 2014 Jul 02; 64(624). PMID: 24982473    Free PMC article.
Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses.
Apostolia-Maria Tsimberidou, Sijin Wen, +10 authors, Donald Berry.
Clin Cancer Res, 2014 Jul 06; 20(18). PMID: 24987059    Free PMC article.
Highly Cited.
Rare-variant association analysis: study designs and statistical tests.
Seunggeung Lee, Gonçalo R Abecasis, Michael Boehnke, Xihong Lin.
Am J Hum Genet, 2014 Jul 06; 95(1). PMID: 24995866    Free PMC article.
Highly Cited. Review.
Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification, using an independent prospective breast cancer cohort and external patient populations.
Dong-Yu Wang, Susan J Done, David R Mc Cready, Wey L Leong.
Breast Cancer Res, 2014 Jul 06; 16(4). PMID: 24996446    Free PMC article.
A diagnostic illusory? The case of distinguishing between "vegetative" and "minimally conscious" states.
Sarah Nettleton, Jenny Kitzinger, Celia Kitzinger.
Soc Sci Med, 2014 Jul 06; 116. PMID: 24997443    Free PMC article.
Inferring clonal composition from multiple sections of a breast cancer.
Habil Zare, Junfeng Wang, +7 authors, William Stafford Noble.
PLoS Comput Biol, 2014 Jul 11; 10(7). PMID: 25010360    Free PMC article.
Chromosome-breakage genomic instability and chromothripsis in breast cancer.
Ewa Przybytkowski, Elizabeth Lenkiewicz, +4 authors, Mark Basik.
BMC Genomics, 2014 Jul 12; 15. PMID: 25011954    Free PMC article.
GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).
Gina M Sizemore, Steven T Sizemore, Darcie D Seachrist, Ruth A Keri.
J Biol Chem, 2014 Jul 12; 289(35). PMID: 25012653    Free PMC article.
Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data.
Oana A Tomescu, Diethard Mattanovich, Gerhard G Thallinger.
BMC Syst Biol, 2014 Jul 18; 8 Suppl 2. PMID: 25033389    Free PMC article.
Functional characterization of breast cancer using pathway profiles.
Feng Tian, Yajie Wang, Michael Seiler, Zhenjun Hu.
BMC Med Genomics, 2014 Jul 22; 7. PMID: 25041817    Free PMC article.
Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast.
Salvatore Piscuoglio, Charlotte K Y Ng, +10 authors, Jorge S Reis-Filho.
Mol Oncol, 2014 Jul 22; 8(8). PMID: 25041824    Free PMC article.
Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study).
M Quintela-Fandino, A Urruticoechea, +11 authors, R Colomer.
Br J Cancer, 2014 Jul 25; 111(6). PMID: 25058346    Free PMC article.
miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer.
Jun Wang, Efrosini Tsouko, +4 authors, Cecilia Williams.
Mol Oncol, 2014 Jul 31; 8(8). PMID: 25074552    Free PMC article.
Clonal evolution in breast cancer revealed by single nucleus genome sequencing.
Yong Wang, Jill Waters, +13 authors, Nicholas E Navin.
Nature, 2014 Aug 01; 512(7513). PMID: 25079324    Free PMC article.
Highly Cited.
The mammary cellular hierarchy and breast cancer.
Samantha R Oakes, David Gallego-Ortega, Christopher J Ormandy.
Cell Mol Life Sci, 2014 Aug 01; 71(22). PMID: 25080108    Free PMC article.
Review.
Molecular homology and difference between spontaneous canine mammary cancer and human breast cancer.
Deli Liu, Huan Xiong, +5 authors, Shaying Zhao.
Cancer Res, 2014 Aug 02; 74(18). PMID: 25082814    Free PMC article.
Can we negotiate with a tumor?
Claire M Wolfrom, Michel Laurent, Jean Deschatrette.
PLoS One, 2014 Aug 02; 9(8). PMID: 25084359    Free PMC article.
Bias correction for selecting the minimal-error classifier from many machine learning models.
Ying Ding, Shaowu Tang, +4 authors, George C Tseng.
Bioinformatics, 2014 Aug 03; 30(22). PMID: 25086004    Free PMC article.
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.
Keren Yizhak, Sylvia E Le Dévédec, +6 authors, Eytan Ruppin.
Mol Syst Biol, 2014 Aug 03; 10. PMID: 25086087    Free PMC article.
Highly Cited.
Tissue slide-based microRNA characterization of tumors: how detailed could diagnosis become for cancer medicine?
Lorenzo F Sempere.
Expert Rev Mol Diagn, 2014 Aug 05; 14(7). PMID: 25090088    Free PMC article.
Review.
Predicting response and survival in chemotherapy-treated triple-negative breast cancer.
A Prat, A Lluch, +35 authors, E Alba.
Br J Cancer, 2014 Aug 08; 111(8). PMID: 25101563    Free PMC article.
Candidate prognostic markers in breast cancer: focus on extracellular proteases and their inhibitors.
David M Roy, Logan A Walsh.
Breast Cancer (Dove Med Press), 2014 Aug 13; 6. PMID: 25114586    Free PMC article.
Review.
Biological subtypes of breast cancer: Prognostic and therapeutic implications.
Ozlem Yersal, Sabri Barutca.
World J Clin Oncol, 2014 Aug 13; 5(3). PMID: 25114856    Free PMC article.
Highly Cited. Review.
How many etiological subtypes of breast cancer: two, three, four, or more?
William F Anderson, Philip S Rosenberg, +2 authors, Mark E Sherman.
J Natl Cancer Inst, 2014 Aug 15; 106(8). PMID: 25118203    Free PMC article.
Highly Cited. Review.
Through a glass darkly: economics and personalised medicine.
Alan Haycox, Munir Pirmohamed, +2 authors, Sarah Richards.
Pharmacoeconomics, 2014 Aug 15; 32(11). PMID: 25118988
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Anieta M Sieuwerts, Scooter Willis, +11 authors, John W M Martens.
Horm Cancer, 2014 Aug 16; 5(6). PMID: 25123150    Free PMC article.
Highly Cited.
Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Nicole Sänger, Eugen Ruckhäberle, +7 authors, Thomas Karn.
Mol Oncol, 2014 Aug 19; 9(1). PMID: 25131496    Free PMC article.
Integrating multi-omics for uncovering the architecture of cross-talking pathways in breast cancer.
Li Wang, Yun Xiao, +8 authors, Xia Li.
PLoS One, 2014 Aug 20; 9(8). PMID: 25137136    Free PMC article.
Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer.
Aleix Prat, Lisa A Carey, +6 authors, José Baselga.
J Natl Cancer Inst, 2014 Aug 21; 106(8). PMID: 25139534    Free PMC article.
Highly Cited.
Synergistic antitumor effects of S-1 with eribulin in vitro and in vivo for triple-negative breast cancer cell lines.
Masato Terashima, Kazuko Sakai, +4 authors, Kazuto Nishio.
Springerplus, 2014 Aug 21; 3. PMID: 25140293    Free PMC article.
Age-specific changes in intrinsic breast cancer subtypes: a focus on older women.
Emily O Jenkins, Allison M Deal, +4 authors, Hyman B Muss.
Oncologist, 2014 Aug 22; 19(10). PMID: 25142841    Free PMC article.
A meta-analysis of multiple matched copy number and transcriptomics data sets for inferring gene regulatory relationships.
Richard Newton, Lorenz Wernisch.
PLoS One, 2014 Aug 26; 9(8). PMID: 25148247    Free PMC article.
NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma.
Bo-Hua Su, Jing Qu, +11 authors, You-Guang Lu.
Oncotarget, 2014 Aug 26; 5(16). PMID: 25149541    Free PMC article.
An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer.
Michael L Gatza, Grace O Silva, +2 authors, Charles M Perou.
Nat Genet, 2014 Aug 26; 46(10). PMID: 25151356    Free PMC article.
Highly Cited.
Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells.
G Kenneth Gray, Braden C McFarland, +2 authors, Etty N Benveniste.
Oncotarget, 2014 Aug 26; 5(15). PMID: 25153725    Free PMC article.
Cancer progression modeling using static sample data.
Yijun Sun, Jin Yao, Norma J Nowak, Steve Goodison.
Genome Biol, 2014 Aug 27; 15(8). PMID: 25155694    Free PMC article.
Genome-driven integrated classification of breast cancer validated in over 7,500 samples.
H Raza Ali, Oscar M Rueda, +4 authors, Carlos Caldas.
Genome Biol, 2014 Aug 29; 15(8). PMID: 25164602    Free PMC article.
Highly Cited.
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.
Hans Kristian Moen Vollan, Oscar M Rueda, +22 authors, Carlos Caldas.
Mol Oncol, 2014 Aug 30; 9(1). PMID: 25169931    Free PMC article.
Linking signaling pathways to transcriptional programs in breast cancer.
Hatice U Osmanbeyoglu, Raphael Pelossof, Jacqueline F Bromberg, Christina S Leslie.
Genome Res, 2014 Sep 04; 24(11). PMID: 25183703    Free PMC article.
Systems consequences of amplicon formation in human breast cancer.
Koichiro Inaki, Francesca Menghi, +16 authors, Edison T Liu.
Genome Res, 2014 Sep 05; 24(10). PMID: 25186909    Free PMC article.
Weibull regression with Bayesian variable selection to identify prognostic tumour markers of breast cancer survival.
P J Newcombe, H Raza Ali, +4 authors, S Richardson.
Stat Methods Med Res, 2014 Sep 07; 26(1). PMID: 25193065    Free PMC article.
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy.
Nada Albarakati, Tarek M A Abdel-Fatah, +14 authors, Srinivasan Madhusudan.
Mol Oncol, 2014 Sep 11; 9(1). PMID: 25205036    Free PMC article.
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways.
Sarah R Hosford, Todd W Miller.
Pharmgenomics Pers Med, 2014 Sep 11; 7. PMID: 25206307    Free PMC article.
Review.
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.
Matthew D Burstein, Anna Tsimelzon, +10 authors, Powel H Brown.
Clin Cancer Res, 2014 Sep 12; 21(7). PMID: 25208879    Free PMC article.
Highly Cited.
Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling.
C Henry, A Quadir, +6 authors, C E Ford.
J Cancer Res Clin Oncol, 2014 Sep 12; 141(2). PMID: 25209439
MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.
Lu Deng, Li Shang, +24 authors, Suling Liu.
Cancer Res, 2014 Sep 14; 74(22). PMID: 25217527    Free PMC article.
The AURORA initiative for metastatic breast cancer.
D Zardavas, M Maetens, +19 authors, M Piccart.
Br J Cancer, 2014 Sep 17; 111(10). PMID: 25225904    Free PMC article.
Review.
Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense.
Angelo D'Alessandro, Ivano Amelio, +4 authors, Lello Zolla.
Oncotarget, 2014 Sep 18; 5(17). PMID: 25229745    Free PMC article.
Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients.
Irène Baccelli, Albrecht Stenzinger, +11 authors, Andreas Trumpp.
Oncotarget, 2014 Sep 18; 5(18). PMID: 25230070    Free PMC article.
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Maya Ghoussaini, Stacey L Edwards, +210 authors, Australian Ovarian Cancer Management Group.
Nat Commun, 2014 Sep 24; 4. PMID: 25248036    Free PMC article.
A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data.
Bo Li, Jun Z Li.
Genome Biol, 2014 Sep 26; 15(9). PMID: 25253082    Free PMC article.
Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.
Heidi N Hilton, Tram B Doan, +14 authors, Christine L Clarke.
Oncotarget, 2014 Sep 28; 5(18). PMID: 25261374    Free PMC article.
Integrative analysis of cancer imaging readouts by networks.
Marco Dominietto, Nicholas Tsinoremas, Enrico Capobianco.
Mol Oncol, 2014 Sep 30; 9(1). PMID: 25263240    Free PMC article.
Review.
Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy.
Sandro Santagata, Tan A Ince.
Expert Rev Anticancer Ther, 2014 Sep 30; 14(12). PMID: 25263303    Free PMC article.
Mechanism-based cancer therapy: resistance to therapy, therapy for resistance.
P Ramos, M Bentires-Alj.
Oncogene, 2014 Sep 30; 34(28). PMID: 25263438
Highly Cited. Review.
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.
M P Licciardello, M K Müllner, +13 authors, S Kubicek.
Oncogene, 2014 Sep 30; 34(29). PMID: 25263445
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes.
Kristin Reiche, Katharina Kasack, +9 authors, Lars O Baumbusch.
PLoS One, 2014 Sep 30; 9(9). PMID: 25264628    Free PMC article.
Dynamic classification using case-specific training cohorts outperforms static gene expression signatures in breast cancer.
Balázs Győrffy, Thomas Karn, +3 authors, Lajos Pusztai.
Int J Cancer, 2014 Oct 03; 136(9). PMID: 25274406    Free PMC article.
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.
Mattia Lauriola, Yehoshua Enuka, +17 authors, Yosef Yarden.
Nat Commun, 2014 Oct 04; 5. PMID: 25278152    Free PMC article.
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
L M Dillon, J R Bean, +9 authors, T W Miller.
Oncogene, 2014 Oct 07; 34(30). PMID: 25284585    Free PMC article.
Combined analysis of copy number alterations by single-nucleotide polymorphism array and MYC status in non-metastatic breast cancer patients: comparison according to the circulating tumor cell status.
R Nadal, M Salido, +8 authors, F Solé.
Tumour Biol, 2014 Oct 08; 36(2). PMID: 25286758
Cancer evolution: mathematical models and computational inference.
Niko Beerenwinkel, Roland F Schwarz, Moritz Gerstung, Florian Markowetz.
Syst Biol, 2014 Oct 09; 64(1). PMID: 25293804    Free PMC article.
Highly Cited. Review.
Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer.
Tingting Jiang, Weiwei Shi, +5 authors, Christos Hatzis.
BMC Genomics, 2014 Oct 09; 15. PMID: 25294321    Free PMC article.
Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences.
Mark Kriegsmann, Volker Endris, +8 authors, Wilko Weichert.
Oncotarget, 2014 Oct 10; 5(20). PMID: 25296970    Free PMC article.
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.
Juliet Kenicer, Melanie Spears, +8 authors, John M S Bartlett.
BMC Cancer, 2014 Oct 15; 14. PMID: 25312014    Free PMC article.
Cancer genomics just got personal.
Rafal T Marszalek.
Genome Biol, 2014 Oct 16; 15(9). PMID: 25315058    Free PMC article.
The multitude of molecular analyses in cancer: the opening of Pandora’s box.
Hege G Russnes, Per E Lønning, Anne-Lise Børresen-Dale, Ole C Lingjærde.
Genome Biol, 2014 Oct 16; 15(9). PMID: 25316146    Free PMC article.
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.
Debora Soncini, Irene Caffa, +19 authors, Alessio Nencioni.
J Biol Chem, 2014 Oct 22; 289(49). PMID: 25331943    Free PMC article.
Integrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling.
Xiaofeng Dai, Ana Chen, Zhonghu Bai.
Sci Rep, 2014 Oct 24; 4. PMID: 25338681    Free PMC article.
Differentiation and loss of malignant character of spontaneous pulmonary metastases in patient-derived breast cancer models.
Jessica Bockhorn, Aleix Prat, +9 authors, Huiping Liu.
Cancer Res, 2014 Oct 24; 74(24). PMID: 25339353    Free PMC article.
Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.
Ruth B McCole, Chamith Y Fonseka, Amnon Koren, C-Ting Wu.
PLoS Genet, 2014 Oct 24; 10(10). PMID: 25340765    Free PMC article.
Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes.
Lauren S Fink, Alexander Beatty, +2 authors, Jeffrey R Peterson.
Mol Cancer Ther, 2014 Oct 26; 14(1). PMID: 25344583    Free PMC article.
ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway.
G Rajapaksa, F Nikolos, +3 authors, C Thomas.
Oncogene, 2014 Oct 28; 34(31). PMID: 25347741
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Twan van den Beucken, Elizabeth Koch, +16 authors, Bradly G Wouters.
Nat Commun, 2014 Oct 30; 5. PMID: 25351418    Free PMC article.
Highly Cited.
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.
David Quigley, Laxmi Silwal-Pandit, +10 authors, Vessela Kristensen.
Mol Cancer Res, 2014 Oct 30; 13(3). PMID: 25351767    Free PMC article.
Correlations of differentially expressed gap junction connexins Cx26, Cx30, Cx32, Cx43 and Cx46 with breast cancer progression and prognosis.
Ivett Teleki, Attila Marcell Szasz, +7 authors, Tibor Krenacs.
PLoS One, 2014 Nov 11; 9(11). PMID: 25383624    Free PMC article.
Brain neoplasms and coagulation-lessons from heterogeneity.
Esterina D'Asti, Yi Fang, Janusz Rak.
Rambam Maimonides Med J, 2014 Nov 12; 5(4). PMID: 25386346    Free PMC article.
Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast.
Felipe Fidalgo, Tatiane Cristina Rodrigues, +6 authors, Ana Cristina Victorino Krepischi.
Tumour Biol, 2014 Nov 14; 36(3). PMID: 25391423    Free PMC article.
Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer.
Stephanie N Dorman, Coby Viner, Peter K Rogan.
Sci Rep, 2014 Nov 15; 4. PMID: 25394353    Free PMC article.
Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.
Gregory Weitsman, Katherine Lawler, +18 authors, Tony Ng.
Biochem Soc Trans, 2014 Nov 18; 42(6). PMID: 25399560    Free PMC article.
Review.
Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .
Britta Weigelt, Charlotte K Y Ng, +8 authors, Jorge S Reis-Filho.
Mod Pathol, 2014 Nov 22; 28(3). PMID: 25412848    Free PMC article.
A framework for generalized subspace pattern mining in high-dimensional datasets.
Edward W J Curry.
BMC Bioinformatics, 2014 Nov 22; 15. PMID: 25413436    Free PMC article.
Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.
Keren Yizhak, Edoardo Gaude, +5 authors, Eytan Ruppin.
Elife, 2014 Nov 22; 3. PMID: 25415239    Free PMC article.
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
H Choudhry, A Albukhari, +11 authors, D R Mole.
Oncogene, 2014 Nov 25; 34(34). PMID: 25417700    Free PMC article.
Highly Cited.
Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance.
Gabriela Nestal de Moraes, Laura Bella, +2 authors, Eric W-F Lam.
Curr Drug Targets, 2014 Nov 25; 17(2). PMID: 25418858    Free PMC article.
Review.
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
Morassa Mohseni, Justin Cidado, +17 authors, Ben Ho Park.
Proc Natl Acad Sci U S A, 2014 Nov 26; 111(49). PMID: 25422431    Free PMC article.
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Tarek M A Abdel-Fatah, Arvind Arora, +10 authors, Srinivasan Madhusudan.
Neoplasia, 2014 Nov 27; 16(11). PMID: 25425972    Free PMC article.
Bioinformatic analysis of cis-regulatory interactions between progesterone and estrogen receptors in breast cancer.
Matloob Khushi, Christine L Clarke, J Dinny Graham.
PeerJ, 2014 Nov 27; 2. PMID: 25426335    Free PMC article.
Integration of genomic data enables selective discovery of breast cancer drivers.
Félix Sanchez-Garcia, Patricia Villagrasa, +9 authors, Dana Pe'er.
Cell, 2014 Dec 01; 159(6). PMID: 25433701    Free PMC article.
CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population.
M Tsuchiya, Y Nakajima, +7 authors, J Yanagisawa.
Oncogene, 2014 Dec 02; 34(35). PMID: 25435366
Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.
Todd A MacKenzie, Gary N Schwartz, +5 authors, Lorenzo F Sempere.
Am J Pathol, 2014 Dec 03; 184(12). PMID: 25440114    Free PMC article.
The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.
Kristen L Karlin, Gourish Mondal, +22 authors, Thomas F Westbrook.
Cell Rep, 2014 Dec 03; 9(4). PMID: 25453754    Free PMC article.
Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.
Tarek M A Abdel-Fatah, Fiona K Middleton, +12 authors, Srinivasan Madhusudan.
Mol Oncol, 2014 Dec 04; 9(3). PMID: 25468710    Free PMC article.
A DNA methylation-based definition of biologically distinct breast cancer subtypes.
Olafur A Stefansson, Sebastian Moran, +9 authors, Manel Esteller.
Mol Oncol, 2014 Dec 04; 9(3). PMID: 25468711    Free PMC article.
Highly Cited.
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.
Peter Eirew, Adi Steif, +43 authors, Samuel Aparicio.
Nature, 2014 Dec 04; 518(7539). PMID: 25470049    Free PMC article.
Highly Cited.
eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN.
Hege G Russnes, Carlos Caldas.
EMBO Mol Med, 2014 Dec 05; 6(12). PMID: 25471453    Free PMC article.
Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer.
Gordon C Wishart, Emad Rakha, +6 authors, Paul D P Pharoah.
BMC Cancer, 2014 Dec 05; 14. PMID: 25472026    Free PMC article.
Breast cancer genetic testing awareness, attitudes and intentions of Latinas living along the US-Mexico border: a qualitative study.
Patricia Chalela, José A Pagán, +2 authors, Amelie G Ramirez.
J Community Med Health Educ, 2012 Jan 01; 2. PMID: 25473590    Free PMC article.
Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α.
Ling Wang, Qingyuan Guo, +2 authors, Aimin Peng.
Cell Cycle, 2014 Dec 09; 14(1). PMID: 25483054    Free PMC article.
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
D C Singleton, P Rouhi, +5 authors, A L Harris.
Oncogene, 2014 Dec 09; 34(36). PMID: 25486436    Free PMC article.
Estrogen as Jekyll and Hyde: regulation of cell death.
Wen Zhou, Xiaoxia Zhu.
F1000Res, 2014 Dec 09; 3. PMID: 25485093    Free PMC article.
Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib.
Xinzhao Wang, Hongkuan Song, +4 authors, Zhiyong Yu.
Oncol Rep, 2014 Dec 17; 33(2). PMID: 25501339    Free PMC article.
Genomic profiling of breast cancers.
Christina Curtis.
Curr Opin Obstet Gynecol, 2014 Dec 17; 27(1). PMID: 25502431    Free PMC article.
Review.
Modelling the spatial heterogeneity and molecular correlates of lymphocytic infiltration in triple-negative breast cancer.
Yinyin Yuan.
J R Soc Interface, 2014 Dec 17; 12(103). PMID: 25505134    Free PMC article.
Emerging Concepts in Breast Cancer Risk Prediction.
Gretchen L Gierach, Xiaohong R Yang, Jonine D Figueroa, Mark E Sherman.
Curr Obstet Gynecol Rep, 2013 Mar 01; 2(1). PMID: 25506515    Free PMC article.
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.
Dylan M Glubb, Mel J Maranian, +215 authors, Juliet D French.
Am J Hum Genet, 2014 Dec 23; 96(1). PMID: 25529635    Free PMC article.
An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.
Jacqueline Salotti, Krisada Sakchaisri, Warren G Tourtellotte, Peter F Johnson.
Mol Cell Biol, 2014 Dec 24; 35(5). PMID: 25535333    Free PMC article.
Mining CK2 in cancer.
Charina E Ortega, Yoshua Seidner, Isabel Dominguez.
PLoS One, 2014 Dec 30; 9(12). PMID: 25541719    Free PMC article.
Highly Cited.
Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.
Kevin Blighe, Laura Kenny, +7 authors, Jacqueline A Shaw.
PLoS One, 2014 Dec 30; 9(12). PMID: 25546409    Free PMC article.
Personalized cancer care conference.
Kurt S Zänker, Enrico Mihich, Hans-Peter Huber, Anne-Lise Borresen-Dale.
J Pers Med, 2013 Jan 01; 3(2). PMID: 25562519    Free PMC article.
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.
Angela Burleigh, Steven McKinney, +11 authors, Samuel Aparicio.
Breast Cancer Res, 2015 Jan 13; 17. PMID: 25572802    Free PMC article.
Normal cell-type epigenetics and breast cancer classification: a case study of cell mixture-adjusted analysis of DNA methylation data from tumors.
Eugene Andrés Houseman, Tan A Ince.
Cancer Inform, 2015 Jan 13; 13(Suppl 4). PMID: 25574126    Free PMC article.
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.
Walid T Khaled, Song Choon Lee, +15 authors, Pentao Liu.
Nat Commun, 2015 Jan 13; 6. PMID: 25574598    Free PMC article.
Highly Cited.
Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy.
Adam D Pfefferle, Benjamin T Spike, Geoff M Wahl, Charles M Perou.
Breast Cancer Res Treat, 2015 Jan 13; 149(2). PMID: 25575446    Free PMC article.
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Zachary T Schug, Barrie Peck, +30 authors, Eyal Gottlieb.
Cancer Cell, 2015 Jan 15; 27(1). PMID: 25584894    Free PMC article.
Highly Cited.
Intrinsic cancer subtypes--next steps into personalized medicine.
Cristina Santos, Rebeca Sanz-Pamplona, +6 authors, Ramon Salazar.
Cell Oncol (Dordr), 2015 Jan 15; 38(1). PMID: 25586691
Review.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.
Syed Haider, Jun Wang, +11 authors, Claude Chelala.
Genome Med, 2015 Jan 15; 6(12). PMID: 25587357    Free PMC article.
Are we able to predict survival in ER-positive HER2-negative breast cancer? A comparison of web-based models.
E Laas, P Mallon, +7 authors, F Reyal.
Br J Cancer, 2015 Jan 16; 112(5). PMID: 25590666    Free PMC article.
Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencoders.
Jie Tan, Matthew Ung, Chao Cheng, Casey S Greene.
Pac Symp Biocomput, 2015 Jan 17;. PMID: 25592575    Free PMC article.
T-ReCS: stable selection of dynamically formed groups of features with application to prediction of clinical outcomes.
Grace T Huang, Ioannis Tsamardinos, +2 authors, Panayiotis V Benos.
Pac Symp Biocomput, 2015 Jan 17;. PMID: 25592602    Free PMC article.
Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer.
Ridha Limame, Ken Op de Beeck, +8 authors, Patrick Pauwels.
Oncoscience, 2015 Jan 17; 1(1). PMID: 25593984    Free PMC article.
The landscape of long noncoding RNAs in the human transcriptome.
Matthew K Iyer, Yashar S Niknafs, +16 authors, Arul M Chinnaiyan.
Nat Genet, 2015 Jan 20; 47(3). PMID: 25599403    Free PMC article.
Highly Cited.
The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.
Hai Wang, Cuijuan Yu, +14 authors, Xiang H-F Zhang.
Cancer Cell, 2015 Jan 21; 27(2). PMID: 25600338    Free PMC article.
Highly Cited.
Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.
Maarten P G Massink, Irsan E Kooi, +18 authors, Hanne Meijers-Heijboer.
Mol Oncol, 2015 Jan 27; 9(4). PMID: 25616998    Free PMC article.
Inferring biological tasks using Pareto analysis of high-dimensional data.
Yuval Hart, Hila Sheftel, +6 authors, Uri Alon.
Nat Methods, 2015 Jan 27; 12(3). PMID: 25622107
A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases.
Nicolas Carels, Tatiana Tilli, Jack A Tuszynski.
PLoS One, 2015 Jan 28; 10(1). PMID: 25625699    Free PMC article.
Computational and analytical challenges in single-cell transcriptomics.
Oliver Stegle, Sarah A Teichmann, John C Marioni.
Nat Rev Genet, 2015 Jan 30; 16(3). PMID: 25628217
Highly Cited. Review.
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.
Cameron N Johnstone, Yvonne E Smith, +17 authors, Robin L Anderson.
Dis Model Mech, 2015 Jan 31; 8(3). PMID: 25633981    Free PMC article.
NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes.
Maria Soledad Sosa, Falguni Parikh, +12 authors, Julio A Aguirre-Ghiso.
Nat Commun, 2015 Jan 31; 6. PMID: 25636082    Free PMC article.
Highly Cited.
The cure: design and evaluation of a crowdsourcing game for gene selection for breast cancer survival prediction.
Benjamin M Good, Salvatore Loguercio, +3 authors, Andrew I Su.
JMIR Serious Games, 2015 Feb 06; 2(2). PMID: 25654473    Free PMC article.
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival.
Ivan O Potapenko, Torben Lüders, +7 authors, Vilde D Haakensen.
Mol Oncol, 2015 Feb 07; 9(4). PMID: 25655580    Free PMC article.
A Big Bang model of human colorectal tumor growth.
Andrea Sottoriva, Haeyoun Kang, +8 authors, Christina Curtis.
Nat Genet, 2015 Feb 11; 47(3). PMID: 25665006    Free PMC article.
Highly Cited.
Prognostic and predictive value of PDL1 expression in breast cancer.
Renaud Sabatier, Pascal Finetti, +7 authors, François Bertucci.
Oncotarget, 2015 Feb 12; 6(7). PMID: 25669979    Free PMC article.
Highly Cited.
Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression.
Hadas Cohen-Dvashi, Nir Ben-Chetrit, +22 authors, Yosef Yarden.
EMBO Mol Med, 2015 Feb 14; 7(3). PMID: 25678558    Free PMC article.
Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.
S Stolzenburg, A S Beltran, +3 authors, P Blancafort.
Oncogene, 2015 Feb 17; 34(43). PMID: 25684141    Free PMC article.
Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network.
P A Fasching, S Y Brucker, +14 authors, A Schneeweiss.
Geburtshilfe Frauenheilkd, 2015 Feb 17; 75(1). PMID: 25684786    Free PMC article.
Novel agents and associated toxicities of inhibitors of the pi3k/Akt/mtor pathway for the treatment of breast cancer.
S Chia, S Gandhi, +8 authors, S F Dent.
Curr Oncol, 2015 Feb 17; 22(1). PMID: 25684987    Free PMC article.
Review.
Application of metabolomics in drug resistant breast cancer research.
Ayesha N Shajahan-Haq, Mehar S Cheema, Robert Clarke.
Metabolites, 2015 Feb 19; 5(1). PMID: 25693144    Free PMC article.
Review.
Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia.
Kavitha Ramaswamy, Barbara Spitzer, Alex Kentsis.
Front Oncol, 2015 Feb 24; 5. PMID: 25699237    Free PMC article.
Review.
Targeting a cell state common to triple-negative breast cancers.
Markus K Muellner, Barbara Mair, +15 authors, Sebastian M B Nijman.
Mol Syst Biol, 2015 Feb 24; 11(1). PMID: 25699542    Free PMC article.
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybridization impact on prognosis in breast cancer.
Jiao Li, Wei Su, +10 authors, Jin Zhang.
Cancer Sci, 2015 Feb 24; 106(5). PMID: 25702787    Free PMC article.
Precision medicine in breast cancer: genes, genomes, and the future of genomically driven treatments.
Daniel G Stover, Nikhil Wagle.
Curr Oncol Rep, 2015 Feb 25; 17(4). PMID: 25708799    Free PMC article.
Review.
Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer.
Sidra Nawaz, Andreas Heindl, Konrad Koelble, Yinyin Yuan.
Mod Pathol, 2015 Feb 28; 28(6). PMID: 25720324
Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations.
Ankit Malhotra, Yong Wang, +4 authors, Nicholas E Navin.
Genome Med, 2015 Mar 03; 7(1). PMID: 25729435    Free PMC article.
APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation.
David W Cescon, Benjamin Haibe-Kains, Tak W Mak.
Proc Natl Acad Sci U S A, 2015 Mar 03; 112(9). PMID: 25730878    Free PMC article.
Highly Cited.
MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.
Kirti Shukla, Ashwini Kumar Sharma, +8 authors, Stefan Wiemann.
Mol Oncol, 2015 Mar 04; 9(6). PMID: 25732226    Free PMC article.
p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.
Elisa Maria Memmi, Anna Giulia Sanarico, +11 authors, Francesca Bernassola.
Proc Natl Acad Sci U S A, 2015 Mar 06; 112(11). PMID: 25739959    Free PMC article.
Highly Cited.
A population-based observational study on the factors associated with the completion of palliative chemotherapy among patients with oesophagogastric cancer.
Oliver Groene, Tom Crosby, +3 authors, David Cromwell.
BMJ Open, 2015 Mar 06; 5(3). PMID: 25740023    Free PMC article.
Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients.
K Simpson, R E Jones, +3 authors, D M Baird.
Mol Oncol, 2015 Mar 11; 9(6). PMID: 25752197    Free PMC article.
p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.
Michelle E Turvey, Manuela Klingler-Hoffmann, Peter Hoffmann, Shaun R McColl.
Immunol Cell Biol, 2015 Mar 11; 93(8). PMID: 25753393
Differential effect of phosphorylation-defective survivin on radiation response in estrogen receptor-positive and -negative breast cancer.
Bisrat G Debeb, Daniel L Smith, +3 authors, Wendy A Woodward.
PLoS One, 2015 Mar 13; 10(3). PMID: 25763854    Free PMC article.
Characterization of genomic alterations in radiation-associated breast cancer among childhood cancer survivors, using comparative genomic hybridization (CGH) arrays.
Xiaohong R Yang, J Keith Killian, +13 authors, Paul Meltzer.
PLoS One, 2015 Mar 13; 10(3). PMID: 25764003    Free PMC article.
HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.
Young-Ho Lee, Xiyong Liu, +3 authors, David K Ann.
PLoS One, 2015 Mar 15; 10(3). PMID: 25769025    Free PMC article.
Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.
Johnathan Watkins, Daniel Weekes, +19 authors, Andrew N J Tutt.
Cancer Discov, 2015 Mar 15; 5(5). PMID: 25770156    Free PMC article.
Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients.
Jonine D Figueroa, Howard Yang, +6 authors, Maxwell Lee.
Breast Cancer Res Treat, 2015 Mar 17; 150(2). PMID: 25773928    Free PMC article.
Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.
Jinfeng Suo, Daniel Medina, +12 authors, Eric C Chang.
Cell Biosci, 2015 Mar 17; 5. PMID: 25774287    Free PMC article.
Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype.
Xiaoyan Huang, Matteo Dugo, +13 authors, Rosaria Orlandi.
Cancer Med, 2015 Mar 20; 4(7). PMID: 25787708    Free PMC article.
Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer.
Christopher R S Banerji, Simone Severini, Carlos Caldas, Andrew E Teschendorff.
PLoS Comput Biol, 2015 Mar 21; 11(3). PMID: 25793737    Free PMC article.
Breast Cancer Update 2014 - Focus on the Patient and the Tumour.
N Maass, F Schütz, +7 authors, M P Lux.
Geburtshilfe Frauenheilkd, 2015 Mar 24; 75(2). PMID: 25797960    Free PMC article.
Cell signaling events differentiate ER-negative subtypes from ER-positive breast cancer.
Maria J Worsham, Dhanajay Chitale, +2 authors, George Divine.
Med Oncol, 2015 Mar 26; 32(5). PMID: 25805566
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology.
Xiaoyun Tang, Matthew G K Benesch, David N Brindley.
J Lipid Res, 2015 Mar 31; 56(11). PMID: 25814022    Free PMC article.
Review.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Man-Li Luo, Chang Gong, +10 authors, Kun Ping Lu.
Cell Rep, 2015 Mar 31; 11(1). PMID: 25818297    Free PMC article.
The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients.
Rainer Fagerholm, Marjanka K Schmidt, +44 authors, Heli Nevanlinna.
Oncotarget, 2015 Apr 01; 6(10). PMID: 25823661    Free PMC article.
Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.
Philip C Schouten, Anita Grigoriadis, +23 authors, Sabine C Linn.
Mol Oncol, 2015 Apr 01; 9(7). PMID: 25825120    Free PMC article.
Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.
Hao Tang, Salwa Sebti, +8 authors, Beth Levine.
EBioMedicine, 2015 Apr 01; 2(3). PMID: 25825707    Free PMC article.
Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.
Angelika Modelska, Alessandro Quattrone, Angela Re.
Brief Bioinform, 2015 Apr 03; 16(6). PMID: 25832647    Free PMC article.
Review.
Detection of pAkt protein in imprint cytology of invasive breast cancer: Correlation with HER2/neu, hormone receptors, and other clinicopathological variables.
Olympia Vasou, Lazaros Skagias, +3 authors, Ekaterini Politi.
Cytojournal, 2015 Apr 04; 12. PMID: 25838835    Free PMC article.
Systemic treatment approaches in her2-negative advanced breast cancer-guidance on the guidelines.
A A Joy, M Ghosh, R Fernandes, M J Clemons.
Curr Oncol, 2015 Apr 08; 22(Suppl 1). PMID: 25848337    Free PMC article.
Review.
Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells.
Sylvie Maubant, Bruno Tesson, +7 authors, Thierry Dubois.
PLoS One, 2015 Apr 08; 10(4). PMID: 25848952    Free PMC article.
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics.
Amy E McCart Reed, Jamie R Kutasovic, Sunil R Lakhani, Peter T Simpson.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849106    Free PMC article.
Highly Cited. Review.
Molecular subtyping for clinically defined breast cancer subgroups.
Xi Zhao, Einar Andreas Rødland, Robert Tibshirani, Sylvia Plevritis.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849221    Free PMC article.
Mouse mammary stem cells express prognostic markers for triple-negative breast cancer.
Kelly J Soady, Howard Kendrick, +8 authors, Matthew J Smalley.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849541    Free PMC article.
Patient-derived xenograft models of breast cancer and their predictive power.
James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849559    Free PMC article.
Highly Cited. Review.
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management.
Eleni van Schooneveld, Hans Wildiers, +3 authors, Steven J Van Laere.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849621    Free PMC article.
Highly Cited. Review.
Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer.
Sergio Granados-Principal, Yi Liu, +12 authors, Jenny C Chang.
Breast Cancer Res, 2015 Apr 08; 17. PMID: 25849745    Free PMC article.
Highly Cited.
Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients.
Michael D Rushton, David A Young, John Loughlin, Louise N Reynard.
Ann Rheum Dis, 2015 Apr 10; 74(9). PMID: 25854584    Free PMC article.
Optimizing sparse sequencing of single cells for highly multiplex copy number profiling.
Timour Baslan, Jude Kendall, +15 authors, James Hicks.
Genome Res, 2015 Apr 11; 25(5). PMID: 25858951    Free PMC article.
PP2A: The Wolf in Sheep's Clothing?
Maeve Kiely, Patrick A Kiely.
Cancers (Basel), 2015 Apr 14; 7(2). PMID: 25867001    Free PMC article.
Review.
Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.
Liangliang Shen, John M O'Shea, +5 authors, Donald E Ayer.
Proc Natl Acad Sci U S A, 2015 Apr 15; 112(17). PMID: 25870263    Free PMC article.
Highly Cited.
Generalized species sampling priors with latent Beta reinforcements.
Edoardo M Airoldi, Thiago Costa, +2 authors, Michele Guindani.
J Am Stat Assoc, 2015 Apr 15; 109(508). PMID: 25870462    Free PMC article.
Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer.
Francisco Beca, Miguel Pereira, +2 authors, Fernando Schmitt.
BMC Cancer, 2015 Apr 17; 15. PMID: 25879784    Free PMC article.
Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer.
Andrew E Teschendorff, Linlin Li, Zhen Yang.
Genome Biol, 2015 Apr 18; 16. PMID: 25886003    Free PMC article.
Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value.
Brian David Lehmann, Yan Ding, +6 authors, Yajun Yi.
BMC Cancer, 2015 Apr 18; 15. PMID: 25886164    Free PMC article.
Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer.
Elena López-Knowles, Paul M Wilkerson, +14 authors, Mitch Dowsett.
Breast Cancer Res, 2015 Apr 19; 17. PMID: 25888249    Free PMC article.
Identification of novel genetic markers of breast cancer survival.
Qi Guo, Marjanka K Schmidt, +144 authors, Paul D P Pharoah.
J Natl Cancer Inst, 2015 Apr 22; 107(5). PMID: 25890600    Free PMC article.
The proteomic landscape of triple-negative breast cancer.
Robert T Lawrence, Elizabeth M Perez, +6 authors, Judit Villén.
Cell Rep, 2015 Apr 22; 11(4). PMID: 25892236    Free PMC article.
Highly Cited.
Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.
Francesco Baschieri, Edith Uetz-von Allmen, Daniel F Legler, Hesso Farhan.
Cell Cycle, 2015 Apr 22; 14(8). PMID: 25892554    Free PMC article.
Clinical management of breast cancer heterogeneity.
Dimitrios Zardavas, Alexandre Irrthum, Charles Swanton, Martine Piccart.
Nat Rev Clin Oncol, 2015 Apr 22; 12(7). PMID: 25895611
Highly Cited. Review.
Common germline polymorphisms associated with breast cancer-specific survival.
Ailith Pirie, Qi Guo, +146 authors, Marjanka K Schmidt.
Breast Cancer Res, 2015 Apr 22; 17. PMID: 25897948    Free PMC article.
Linking gene expression to phenotypes via pathway information.
Irene Papatheodorou, Anika Oellrich, Damian Smedley.
J Biomed Semantics, 2015 Apr 23; 6. PMID: 25901272    Free PMC article.
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Christy C Ong, Sarah Gierke, +28 authors, Klaus P Hoeflich.
Breast Cancer Res, 2015 Apr 24; 17. PMID: 25902869    Free PMC article.
Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial.
J Rodon, J C Soria, +12 authors, R Kurzrock.
Ann Oncol, 2015 Apr 25; 26(8). PMID: 25908602    Free PMC article.
Genome-wide analysis of alternative transcripts in human breast cancer.
Ji Wen, Kevin H Toomer, Zhibin Chen, Xiaodong Cai.
Breast Cancer Res Treat, 2015 Apr 29; 151(2). PMID: 25913416    Free PMC article.
Cell-lineage heterogeneity and driver mutation recurrence in pre-invasive breast neoplasia.
Ziming Weng, Noah Spies, +5 authors, Robert B West.
Genome Med, 2015 Apr 29; 7(1). PMID: 25918554    Free PMC article.
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer.
Laoighse Mulrane, William M Gallagher, Darran P O'Connor.
Breast Cancer Res, 2014 Jan 01; 16(6). PMID: 25927669    Free PMC article.
The molecular landscape of the normal human breast--defining normal.
Heidi N Hilton, J Dinny Graham.
Breast Cancer Res, 2014 Jan 01; 16(3). PMID: 25928365    Free PMC article.
OECI-EACR precision medicine for cancer: Conference report 1-4 March 2015, Luxembourg.
Anna Golebiewska, Sabrina Fritah, Maria Romina Girotti.
Ecancermedicalscience, 2015 May 02; 9. PMID: 25932043    Free PMC article.
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.
Richard Beatson, Gjertrud Maurstad, +8 authors, Joy M Burchell.
PLoS One, 2015 May 08; 10(5). PMID: 25951175    Free PMC article.
Cyclin E deregulation promotes loss of specific genomic regions.
Leonardo K Teixeira, Xianlong Wang, +4 authors, Steven I Reed.
Curr Biol, 2015 May 12; 25(10). PMID: 25959964    Free PMC article.
Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.
Katarzyna B Leszczynska, Iosifina P Foskolou, +7 authors, Ester M Hammond.
J Clin Invest, 2015 May 12; 125(6). PMID: 25961455    Free PMC article.
Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy.
Daniel L Abravanel, George K Belka, +4 authors, Lewis A Chodosh.
J Clin Invest, 2015 May 12; 125(6). PMID: 25961456    Free PMC article.
Matrix metalloproteinases as breast cancer drivers and therapeutic targets.
Evette S Radisky, Derek C Radisky.
Front Biosci (Landmark Ed), 2015 May 12; 20. PMID: 25961550    Free PMC article.
Review.
Pathway-based personalized analysis of breast cancer expression data.
Anna Livshits, Anna Git, +2 authors, Eytan Domany.
Mol Oncol, 2015 May 13; 9(7). PMID: 25963740    Free PMC article.
Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy.
Sofia Khan, Rainer Fagerholm, +6 authors, Heli Nevanlinna.
Clin Cancer Res, 2015 May 13; 21(18). PMID: 25964295    Free PMC article.
Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.
Guilherme A P de Oliveira, Luciana P Rangel, Danielly C Costa, Jerson L Silva.
Front Oncol, 2015 May 15; 5. PMID: 25973395    Free PMC article.
Review.
Identifying Etiologically Distinct Sub-Types of Cancer: A Demonstration Project Involving Breast Cancer.
Colin B Begg, Irene Orlow, +4 authors, Jonine L Bernstein.
Cancer Med, 2015 May 15; 4(9). PMID: 25974664    Free PMC article.
Personalized radiotherapy: concepts, biomarkers and trial design.
A H Ree, K R Redalen.
Br J Radiol, 2015 May 21; 88(1051). PMID: 25989697    Free PMC article.
Review.
Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.
Jason De Melo, Damu Tang.
PLoS One, 2015 May 21; 10(5). PMID: 25992689    Free PMC article.
Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification.
Charlotte K Y Ng, Luciano G Martelotto, +20 authors, Jorge S Reis-Filho.
Genome Biol, 2015 May 23; 16. PMID: 25994018    Free PMC article.
Global transcription network incorporating distal regulator binding reveals selective cooperation of cancer drivers and risk genes.
Kwoneel Kim, Woojin Yang, +7 authors, Jung Kyoon Choi.
Nucleic Acids Res, 2015 May 24; 43(12). PMID: 26001967    Free PMC article.
BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.
Tesa M Severson, Justine Peeters, +16 authors, Sabine Linn.
Mol Oncol, 2015 May 26; 9(8). PMID: 26004083    Free PMC article.
TIPIN depletion leads to apoptosis in breast cancer cells.
Céline Baldeyron, Amélie Brisson, +18 authors, Thierry Dubois.
Mol Oncol, 2015 May 26; 9(8). PMID: 26004086    Free PMC article.
The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study.
Elena Guerini-Rocco, Zsolt Hodi, +15 authors, Jorge S Reis-Filho.
J Pathol, 2015 May 27; 237(2). PMID: 26011570    Free PMC article.
DECODE: an integrated differential co-expression and differential expression analysis of gene expression data.
Thomas W H Lui, Nancy B Y Tsui, +3 authors, Benjamin Y M Yung.
BMC Bioinformatics, 2015 Jun 01; 16. PMID: 26026612    Free PMC article.
Evaluation of two highly-multiplexed custom panels for massively parallel semiconductor sequencing on paraffin DNA.
Vassiliki Kotoula, Aggeliki Lyberopoulou, +7 authors, George Fountzilas.
PLoS One, 2015 Jun 04; 10(6). PMID: 26039550    Free PMC article.
Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay.
Tor W Jensen, Tania Ray, +9 authors, Partha S Ray.
J Natl Cancer Inst, 2015 Jun 05; 107(8). PMID: 26041837    Free PMC article.
The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain.
Rajendra P Pangeni, Prasanna Channathodiyil, +22 authors, Mark R Morris.
Clin Epigenetics, 2015 Jun 09; 7. PMID: 26052355    Free PMC article.
Inference of transcriptional regulation in cancers.
Peng Jiang, Matthew L Freedman, Jun S Liu, Xiaole Shirley Liu.
Proc Natl Acad Sci U S A, 2015 Jun 10; 112(25). PMID: 26056275    Free PMC article.
miR-30e* is an independent subtype-specific prognostic marker in breast cancer.
F D'Aiuto, M Callari, +6 authors, M G Daidone.
Br J Cancer, 2015 Jun 10; 113(2). PMID: 26057454    Free PMC article.
Targeted therapies for ER+/HER2- metastatic breast cancer.
Mutsuko Yamamoto-Ibusuki, Monica Arnedos, Fabrice André.
BMC Med, 2015 Jun 11; 13. PMID: 26059247    Free PMC article.
Review.
Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.
Hang Yang, Wen-Qi Jiang, +11 authors, Yan-Xia Shi.
Dis Markers, 2015 Jun 13; 2015. PMID: 26063961    Free PMC article.
Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate.
Mohd Farhan, Asim Rizvi, +2 authors, Aamir Ahmad.
Tumour Biol, 2015 Jun 13; 36(11). PMID: 26069106
MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene.
Yu Wei Phua, Akira Nguyen, +16 authors, Alexander Swarbrick.
Breast Cancer Res, 2015 Jun 14; 17. PMID: 26070602    Free PMC article.
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
Hatef Darabi, Karen McCue, +128 authors, Georgia Chenevix-Trench.
Am J Hum Genet, 2015 Jun 16; 97(1). PMID: 26073781    Free PMC article.
Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Jing Zhao, Dekuang Zhao, +7 authors, Powel H Brown.
J Clin Invest, 2015 Jun 16; 125(7). PMID: 26075823    Free PMC article.
Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast.
Jia-Min B Pang, Kylie L Gorringe, +3 authors, Stephen B Fox.
Breast Cancer Res, 2015 Jun 17; 17. PMID: 26078038    Free PMC article.
Review.
Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.
Joachim Rudolph, Ignacio Aliagas, +13 authors, Klaus P Hoeflich.
ACS Med Chem Lett, 2015 Jun 24; 6(6). PMID: 26101579    Free PMC article.
CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer.
Justin L Black, J Chuck Harrell, +8 authors, Leslie V Parise.
Breast Cancer Res Treat, 2015 Jun 25; 152(2). PMID: 26105795    Free PMC article.
Race-associated biological differences among Luminal A breast tumors.
Monica D'Arcy, Jodie Fleming, +3 authors, Melissa A Troester.
Breast Cancer Res Treat, 2015 Jun 26; 152(2). PMID: 26109344    Free PMC article.
Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer.
Grace O Silva, Xiaping He, +8 authors, Charles M Perou.
Breast Cancer Res Treat, 2015 Jun 26; 152(2). PMID: 26109346    Free PMC article.
Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer.
Y-W Chang, C-F Tseng, +5 authors, J-L Su.
Oncogene, 2015 Jun 30; 35(12). PMID: 26119938
Evaluation of targeted therapies in advanced breast cancer: the need for large-scale molecular screening and transformative clinical trial designs.
Z Fadoukhair, D Zardavas, +3 authors, M Piccart.
Oncogene, 2015 Jun 30; 35(14). PMID: 26119941
Review.
The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set.
Heloisa Helena Milioli, Renato Vimieiro, +3 authors, Pablo Moscato.
PLoS One, 2015 Jul 02; 10(7). PMID: 26132585    Free PMC article.
Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance.
Loredana Vesci, Valeria Carollo, +4 authors, Rita De Santis.
Oncol Rep, 2015 Jul 03; 34(3). PMID: 26133490    Free PMC article.
Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.
Bryan P Schneider, Lang Li, +20 authors, George W Sledge.
Clin Cancer Res, 2015 Jul 04; 21(22). PMID: 26138065    Free PMC article.
Proangiogenic Properties of Thrombospondin-4.
Santoshi Muppala, Ella Frolova, +6 authors, Olga Stenina-Adognravi.
Arterioscler Thromb Vasc Biol, 2015 Jul 04; 35(9). PMID: 26139464    Free PMC article.
Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients.
Chih-Yang Wang, Ming-Derg Lai, +2 authors, Yen-Chang Lin.
PLoS One, 2015 Jul 07; 10(7). PMID: 26147197    Free PMC article.
Progesterone receptor modulates ERα action in breast cancer.
Hisham Mohammed, I Alasdair Russell, +22 authors, Jason S Carroll.
Nature, 2015 Jul 15; 523(7560). PMID: 26153859    Free PMC article.
Highly Cited.
SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients.
Hei Jason Chan, Haiqing Li, +3 authors, Shiuan Chen.
Oncotarget, 2015 Jul 15; 6(28). PMID: 26158350    Free PMC article.
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.
Heidi Kontro, Giuseppe Cannino, +2 authors, Heikki Kainulainen.
PLoS One, 2015 Jul 15; 10(7). PMID: 26161955    Free PMC article.
Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.
Ze-Yi Zheng, Lin Tian, +14 authors, Eric C Chang.
Cell Rep, 2015 Jul 15; 12(3). PMID: 26166574    Free PMC article.
Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes.
Elana J Fertig, Esak Lee, Niranjan B Pandey, Aleksander S Popel.
Sci Rep, 2015 Jul 16; 5. PMID: 26173622    Free PMC article.
Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts.
John W Cassidy, Carlos Caldas, Alejandra Bruna.
Cancer Res, 2015 Jul 17; 75(15). PMID: 26180079    Free PMC article.
Highly Cited. Review.
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas.
Sunniva Stordal Bjørklund, Vessela N Kristensen, +9 authors, Shridar Ganesan.
BMC Cancer, 2015 Jul 18; 15. PMID: 26183823    Free PMC article.
The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer.
Luca Magnani, Darren K Patten, +22 authors, R Charles Coombes.
Oncotarget, 2015 Jul 29; 6(26). PMID: 26215677    Free PMC article.
Pathway Relevance Ranking for Tumor Samples through Network-Based Data Integration.
Lieven P C Verbeke, Jimmy Van den Eynden, +3 authors, Kathleen Marchal.
PLoS One, 2015 Jul 29; 10(7). PMID: 26217958    Free PMC article.
Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.
Ruth Rodriguez-Barrueco, Jiyang Yu, +13 authors, Jose M Silva.
Genes Dev, 2015 Aug 01; 29(15). PMID: 26227964    Free PMC article.
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Angela M Fala, Juliana F Oliveira, +9 authors, Andre L B Ambrosio.
Sci Rep, 2015 Aug 04; 5. PMID: 26237540    Free PMC article.
From mice to humans: developments in cancer immunoediting.
Michele W L Teng, Jerome Galon, Wolf-Herman Fridman, Mark J Smyth.
J Clin Invest, 2015 Aug 05; 125(9). PMID: 26241053    Free PMC article.
Highly Cited. Review.
A Molecular Portrait of High-Grade Ductal Carcinoma In Situ.
Martin C Abba, Ting Gong, +10 authors, C Marcelo Aldaz.
Cancer Res, 2015 Aug 08; 75(18). PMID: 26249178    Free PMC article.
Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.
D Merino, S W Lok, J E Visvader, G J Lindeman.
Oncogene, 2015 Aug 11; 35(15). PMID: 26257067
Review.
Chromosomal copy number alterations for associations of ductal carcinoma in situ with invasive breast cancer.
Anosheh Afghahi, Erna Forgó, +11 authors, Robert B West.
Breast Cancer Res, 2015 Aug 13; 17. PMID: 26265211    Free PMC article.
Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.
Alexandra Van Keymeulen, May Yin Lee, +10 authors, Cédric Blanpain.
Nature, 2015 Aug 13; 525(7567). PMID: 26266985
Highly Cited.
The changing role of ER in endocrine resistance.
Agostina Nardone, Carmine De Angelis, +2 authors, Rachel Schiff.
Breast, 2015 Aug 15; 24 Suppl 2. PMID: 26271713    Free PMC article.
Review.
Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer.
Meng-Lay Lin, Hetal Patel, +20 authors, Simak Ali.
Oncotarget, 2015 Aug 19; 6(25). PMID: 26280373    Free PMC article.
Exploring miRNA-Associated Signatures with Diagnostic Relevance in Glioblastoma Multiforme and Breast Cancer Patients.
Véronique C LeBlanc, Pier Morin.
J Clin Med, 2015 Aug 20; 4(8). PMID: 26287251    Free PMC article.
Review.
ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.
M Pieraccioli, S Nicolai, +4 authors, G Raschellà.
Oncogene, 2015 Aug 25; 35(20). PMID: 26300006
A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.
George Giotopoulos, Louise van der Weyden, +13 authors, Brian J P Huntly.
J Exp Med, 2015 Aug 26; 212(10). PMID: 26304963    Free PMC article.
IDEA: Integrated Drug Expression Analysis-Integration of Gene Expression and Clinical Data for the Identification of Therapeutic Candidates.
M H Ung, F S Varn, C Cheng.
CPT Pharmacometrics Syst Pharmacol, 2015 Aug 28; 4(7). PMID: 26312165    Free PMC article.
An integrated network platform for contextual prioritization of drugs and pathways.
Aldo Segura-Cabrera, Navneet Singh, Kakajan Komurov.
Mol Biosyst, 2015 Sep 01; 11(11). PMID: 26315485    Free PMC article.
Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets.
Songjian Lu, Kevin N Lu, +4 authors, Xinghua Lu.
PLoS Comput Biol, 2015 Sep 01; 11(8). PMID: 26317392    Free PMC article.
SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.
Maral Jamshidi, Rainer Fagerholm, +55 authors, Heli Nevanlinna.
Oncotarget, 2015 Sep 01; 6(35). PMID: 26317411    Free PMC article.
KMT Set7/9 affects genotoxic stress response via the Mdm2 axis.
Larissa Lezina, Vasilisa Aksenova, +7 authors, Nikolai A Barlev.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26317544    Free PMC article.
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Xiaoping Zhu, Jing Zhong, +7 authors, Stephen Wong.
Oncotarget, 2015 Sep 01; 6(28). PMID: 26318291    Free PMC article.
Copy number analysis of ductal carcinoma in situ with and without recurrence.
Kylie L Gorringe, Sally M Hunter, +9 authors, Ian G Campbell.
Mod Pathol, 2015 Sep 01; 28(9). PMID: 26321097
Immunohistochemical, genetic and epigenetic profiles of hereditary and triple negative breast cancers. Relevance in personalized medicine.
Rosa Murria, Sarai Palanca, +14 authors, Pascual Bolufer.
Am J Cancer Res, 2015 Sep 04; 5(7). PMID: 26328265    Free PMC article.
Whole-transcriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration.
Tiziana Triulzi, Loris De Cecco, +12 authors, Elda Tagliabue.
Oncotarget, 2015 Sep 04; 6(29). PMID: 26334217    Free PMC article.
The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity.
Pratima Basak, Rachelle Dillon, +2 authors, Michael R A Mowat.
BMC Cancer, 2015 Sep 12; 15. PMID: 26353792    Free PMC article.
Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.
Xingyi Guo, Jirong Long, +112 authors, Wei Zheng.
Cancer Epidemiol Biomarkers Prev, 2015 Sep 12; 24(11). PMID: 26354892    Free PMC article.
Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma.
Matthew A Care, David R Westhead, Reuben M Tooze.
Genome Med, 2015 Sep 13; 7. PMID: 26362649    Free PMC article.
A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.
Nicholas C D'Amato, Thomas J Rogers, +7 authors, Jennifer K Richer.
Cancer Res, 2015 Sep 13; 75(21). PMID: 26363006    Free PMC article.
Highly Cited.
Neddylation controls basal MKK7 kinase activity in breast cancer cells.
T Zhu, J Wang, +7 authors, J Zhang.
Oncogene, 2015 Sep 15; 35(20). PMID: 26364603
4-IHC classification of breast cancer subtypes in a large cohort of a clinical cancer registry: use in clinical routine for therapeutic decisions and its effect on survival.
Elisabeth Christine Inwald, M Koller, +5 authors, O Ortmann.
Breast Cancer Res Treat, 2015 Sep 16; 153(3). PMID: 26369534    Free PMC article.
Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival.
Wout Megchelenbrink, Rotem Katzir, +2 authors, Richard A Notebaart.
Proc Natl Acad Sci U S A, 2015 Sep 16; 112(39). PMID: 26371301    Free PMC article.
Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions.
Oihana Iriondo, Miriam Rábano, +5 authors, Maria dM Vivanco.
Oncotarget, 2015 Sep 16; 6(31). PMID: 26372732    Free PMC article.
Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.
Zhong Chen, Xun Lan, +7 authors, Qianben Wang.
Nat Commun, 2015 Sep 17; 6. PMID: 26374485    Free PMC article.
Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis.
Milica Pavlovic, Anna Arnal-Estapé, +16 authors, Roger R Gomis.
J Natl Cancer Inst, 2015 Sep 18; 107(12). PMID: 26376684    Free PMC article.
Targeting Breast Cancer Metastasis.
Xin Jin, Ping Mu.
Breast Cancer (Auckl), 2015 Sep 19; 9(Suppl 1). PMID: 26380552    Free PMC article.
Review.
An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer.
Carlo C Maley, Konrad Koelble, +2 authors, Yinyin Yuan.
Breast Cancer Res, 2015 Sep 24; 17(1). PMID: 26395345    Free PMC article.
Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility.
Ricardo Martinez, Alessandra Blasina, +14 authors, Brion W Murray.
PLoS One, 2015 Sep 24; 10(9). PMID: 26398286    Free PMC article.
APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.
Manikandan Periyasamy, Hetal Patel, +17 authors, Simak Ali.
Cell Rep, 2015 Sep 29; 13(1). PMID: 26411678    Free PMC article.
Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.
Nucharee Yokdang, Senny Nordmeier, +2 authors, Iain L O Buxton.
Integr Cancer Sci Ther, 2015 Sep 29; 2(4). PMID: 26413311    Free PMC article.
Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling.
Wei Zhang, Liraz Levi, +2 authors, Noa Noy.
Oncotarget, 2015 Sep 30; 6(34). PMID: 26416422    Free PMC article.
The path to routine use of genomic biomarkers in the cancer clinic.
Paul C Boutros.
Genome Res, 2015 Oct 03; 25(10). PMID: 26430161    Free PMC article.
Review.
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.
Jiarui Ding, Melissa K McConechy, +11 authors, Sohrab P Shah.
Nat Commun, 2015 Oct 06; 6. PMID: 26436532    Free PMC article.
Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.
L V Rhodes, C R Tate, +11 authors, B M Collins-Burow.
Oncogenesis, 2015 Oct 06; 4. PMID: 26436950    Free PMC article.
Genomic landscapes of breast fibroepithelial tumors.
Jing Tan, Choon Kiat Ong, +37 authors, Bin Tean Teh.
Nat Genet, 2015 Oct 06; 47(11). PMID: 26437033
Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival.
Stephen P Fink, Lois L Myeroff, +12 authors, Sanford D Markowitz.
Oncotarget, 2015 Oct 06; 6(31). PMID: 26437221    Free PMC article.
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.
Debora Fumagalli, David Gacquer, +16 authors, Vincent Detours.
Cell Rep, 2015 Oct 07; 13(2). PMID: 26440892    Free PMC article.
Highly Cited.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Giovanni Ciriello, Michael L Gatza, +30 authors, Charles M Perou.
Cell, 2015 Oct 10; 163(2). PMID: 26451490    Free PMC article.
Highly Cited.
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.
Chao Liu, Sriganesh Srihari, +5 authors, Kim-Anh Lê Cao.
Mol Oncol, 2015 Oct 13; 10(1). PMID: 26456802    Free PMC article.
Public data and open source tools for multi-assay genomic investigation of disease.
Lavanya Kannan, Marcel Ramos, +12 authors, Levi Waldron.
Brief Bioinform, 2015 Oct 16; 17(4). PMID: 26463000    Free PMC article.
Review.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Jing Zhang, Chengyang Wang, +11 authors, Qing Zhang.
EMBO J, 2015 Oct 27; 34(23). PMID: 26492917    Free PMC article.
Overshoot during phenotypic switching of cancer cell populations.
Alessandro L Sellerio, Emilio Ciusani, +7 authors, Caterina A M La Porta.
Sci Rep, 2015 Oct 27; 5. PMID: 26494317    Free PMC article.
FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies.
Antonio Martínez-Aranda, Vanessa Hernández, +16 authors, Angels Sierra.
Oncotarget, 2015 Oct 27; 6(42). PMID: 26497551    Free PMC article.
The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage.
Matthew D Buschman, Mengke Xing, Seth J Field.
Front Neurosci, 2015 Oct 27; 9. PMID: 26500484    Free PMC article.
Review.
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.
H Ross-Adams, A D Lamb, +22 authors, CamCaP Study Group.
EBioMedicine, 2015 Oct 27; 2(9). PMID: 26501111    Free PMC article.
Highly Cited.
A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker.
Victor M Bii, Dustin T Rae, Grant D Trobridge.
Oncotarget, 2015 Oct 28; 6(37). PMID: 26506596    Free PMC article.
All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.
Jaya Sangodkar, Caroline C Farrington, +3 authors, Goutham Narla.
FEBS J, 2015 Oct 29; 283(6). PMID: 26507691    Free PMC article.
Highly Cited. Review.
The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical-genomic driver associations.
HoJoon Lee, Jennifer Palm, Susan M Grimes, Hanlee P Ji.
Genome Med, 2015 Oct 29; 7. PMID: 26507825    Free PMC article.
A Gene Regulatory Program in Human Breast Cancer.
Renhua Li, John Campos, Joji Iida.
Genetics, 2015 Oct 30; 201(4). PMID: 26510790    Free PMC article.
Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6.
Yu-Chun Hsiao, Ming-Hsin Yeh, +3 authors, Wei-Chien Huang.
Oncotarget, 2015 Oct 30; 6(35). PMID: 26513016    Free PMC article.
Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter.
Elizabeth Poli, Jing Zhang, +4 authors, Yoo-Jeong Han.
PLoS One, 2015 Nov 06; 10(11). PMID: 26539832    Free PMC article.
Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.
Peter C Hart, Bianca A Ratti, +5 authors, Marcelo G Bonini.
Oncotarget, 2015 Nov 07; 7(1). PMID: 26543228    Free PMC article.
Expression of androgen receptor splice variants in clinical breast cancers.
Theresa E Hickey, Connie M Irvine, +15 authors, Luke A Selth.
Oncotarget, 2015 Nov 12; 6(42). PMID: 26554309    Free PMC article.
p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells.
Ting Zhuang, Jian Zhu, +4 authors, Staffan Strömblad.
Oncotarget, 2015 Nov 12; 6(41). PMID: 26554417    Free PMC article.
Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions.
Faraz K Mardakheh, Angela Paul, +5 authors, Christopher J Marshall.
Dev Cell, 2015 Nov 12; 35(3). PMID: 26555054    Free PMC article.
γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers.
Nuša Trošt, Samuel Peña-Llopis, +4 authors, Elisabeth D Martinez.
Oncotarget, 2015 Nov 12; 7(3). PMID: 26556877    Free PMC article.
Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.
Stefan Werner, Hauke Stamm, +4 authors, Harriet Wikman.
BMC Cancer, 2015 Nov 13; 15. PMID: 26560478    Free PMC article.
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.
Bingchen Han, Ying Qu, +21 authors, Xiaojiang Cui.
Cell Rep, 2015 Nov 14; 13(5). PMID: 26565916    Free PMC article.
Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein.
Jana Koo, Stephanie Cabarcas-Petroski, +3 authors, Laura Schramm.
BMC Cancer, 2015 Nov 18; 15. PMID: 26573593    Free PMC article.
Genetics: Big hopes for big data.
Jill U Adams.
Nature, 2015 Nov 19; 527(7578). PMID: 26580158
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Arvind Arora, Tarek M A Abdel-Fatah, +14 authors, Srinivasan Madhusudan.
Carcinogenesis, 2015 Nov 21; 37(1). PMID: 26586793    Free PMC article.
An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.
Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Zeng-Quan Yang.
Mol Oncol, 2015 Nov 22; 10(2). PMID: 26588862    Free PMC article.
Uterine adenosarcomas are mesenchymal neoplasms.
Salvatore Piscuoglio, Kathleen A Burke, +13 authors, Britta Weigelt.
J Pathol, 2015 Nov 26; 238(3). PMID: 26592504    Free PMC article.
Identifying Triple-Negative Breast Cancer Using Background Parenchymal Enhancement Heterogeneity on Dynamic Contrast-Enhanced MRI: A Pilot Radiomics Study.
Jeff Wang, Fumi Kato, +6 authors, Hiroki Shirato.
PLoS One, 2015 Nov 26; 10(11). PMID: 26600392    Free PMC article.
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells.
David A Quigley, Vessela Kristensen.
Mol Oncol, 2015 Nov 27; 9(10). PMID: 26607741    Free PMC article.
Review.
Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.
Jorge Vera, Lydia Lartigue, +7 authors, Anna Castro.
Elife, 2015 Nov 28; 4. PMID: 26613407    Free PMC article.
Regulators of genetic risk of breast cancer identified by integrative network analysis.
Mauro A A Castro, Ines de Santiago, +7 authors, Kerstin B Meyer.
Nat Genet, 2015 Dec 01; 48(1). PMID: 26618344    Free PMC article.
MiRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer.
Andrea Mathe, Rodney J Scott, Kelly A Avery-Kiejda.
Int J Mol Sci, 2015 Dec 04; 16(12). PMID: 26633365    Free PMC article.
Review.
Claudin 1 in Breast Cancer: New Insights.
Bowen Zhou, Amanda Moodie, +2 authors, Yvonne Myal.
J Clin Med, 2015 Dec 04; 4(12). PMID: 26633531    Free PMC article.
Review.
Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis.
Michel Wassef, Veronica Rodilla, +20 authors, Raphaël Margueron.
Genes Dev, 2015 Dec 08; 29(24). PMID: 26637281    Free PMC article.
Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-β1 signaling pathway.
Sangmin Kim, Jeongmin Lee, +2 authors, Seok Jin Nam.
Oncotarget, 2015 Dec 08; 7(2). PMID: 26637807    Free PMC article.
Deciphering Genomic Underpinnings of Quantitative MRI-based Radiomic Phenotypes of Invasive Breast Carcinoma.
Yitan Zhu, Hui Li, +4 authors, Yuan Ji.
Sci Rep, 2015 Dec 08; 5. PMID: 26639025    Free PMC article.
Biomarkers in Breast Cancer - An Update.
M Schmidt, P A Fasching, M W Beckmann, H Kölbl.
Geburtshilfe Frauenheilkd, 2012 Sep 01; 72(9). PMID: 26640290    Free PMC article.
High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors.
Arvind Thakkar, Hemanth Raj, +3 authors, Muralidhara Padigaru.
Biomark Insights, 2015 Dec 10; 10. PMID: 26648682    Free PMC article.
Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers.
Brett A Clementz, John A Sweeney, +5 authors, Carol A Tamminga.
Am J Psychiatry, 2015 Dec 15; 173(4). PMID: 26651391    Free PMC article.
Highly Cited.
Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer.
Clara Bodelon, Svetlana Vinokurova, +16 authors, Nicolas Wentzensen.
Carcinogenesis, 2015 Dec 15; 37(2). PMID: 26660085    Free PMC article.
The integrative epigenomic-transcriptomic landscape of ER positive breast cancer.
Yang Gao, Allison Jones, +4 authors, Andrew E Teschendorff.
Clin Epigenetics, 2015 Dec 15; 7. PMID: 26664652    Free PMC article.
Mutation Screening of 1,237 Cancer Genes across Six Model Cell Lines of Basal-Like Breast Cancer.
Eleonor Olsson, Christof Winter, +6 authors, Lao H Saal.
PLoS One, 2015 Dec 17; 10(12). PMID: 26670335    Free PMC article.
Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.
Mae A Goldgraben, Roslin Russell, +2 authors, Anna Git.
RNA, 2015 Dec 17; 22(2). PMID: 26670622    Free PMC article.
TP53 Mutational Analysis Enhances the Prognostic Accuracy of IHC4 and PAM50 Assays.
Ching-Hung Lin, I-Chiun Chen, +11 authors, Ann-Lii Cheng.
Sci Rep, 2015 Dec 17; 5. PMID: 26671300    Free PMC article.
Conserved E2F mediated metastasis in mouse models of breast cancer and HER2 positive patients.
Jonathan Rennhack, Eran Andrechek.
Oncoscience, 2015 Dec 19; 2(10). PMID: 26682278    Free PMC article.
Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.
Ana Tufegdzic Vidakovic, Oscar M Rueda, +7 authors, Carlos Caldas.
Cell Rep, 2015 Dec 22; 13(11). PMID: 26686634    Free PMC article.
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.
Christina G Towers, Anna L Guarnieri, +13 authors, Heide L Ford.
Nat Commun, 2015 Dec 22; 6. PMID: 26687066    Free PMC article.
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
Arvind Arora, Devika Agarwal, +14 authors, Srinivasan Madhusudan.
J Pathol, 2015 Dec 23; 238(4). PMID: 26690729    Free PMC article.
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.
Silvia Di Agostino, Giovanni Sorrentino, +7 authors, Giovanni Blandino.
EMBO Rep, 2015 Dec 23; 17(2). PMID: 26691213    Free PMC article.
Highly Cited.
Developmental genes significantly afflicted by aberrant promoter methylation and somatic mutation predict overall survival of late-stage colorectal cancer.
Ning An, Xue Yang, +2 authors, Kaitai Zhang.
Sci Rep, 2015 Dec 23; 5. PMID: 26691761    Free PMC article.
Breast cancer intrinsic subtype classification, clinical use and future trends.
Xiaofeng Dai, Ting Li, +4 authors, Bozhi Shi.
Am J Cancer Res, 2015 Dec 23; 5(10). PMID: 26693050    Free PMC article.
Highly Cited. Review.
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
David Gallego-Ortega, Anita Ledger, +28 authors, Christopher J Ormandy.
PLoS Biol, 2015 Dec 31; 13(12). PMID: 26717410    Free PMC article.
HER2 drives Mucin-like 1 to control proliferation in breast cancer cells.
S J Conley, E E Bosco, +3 authors, Z Xiao.
Oncogene, 2016 Jan 05; 35(32). PMID: 26725324    Free PMC article.
Proteomic maps of breast cancer subtypes.
Stefka Tyanova, Reidar Albrechtsen, +3 authors, Tamar Geiger.
Nat Commun, 2016 Jan 05; 7. PMID: 26725330    Free PMC article.
Highly Cited.
Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles.
Frederick S Varn, Erik H Andrews, David W Mullins, Chao Cheng.
Nat Commun, 2016 Jan 05; 7. PMID: 26725977    Free PMC article.
DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer.
Kirsty J Flower, Natalie S Shenker, +8 authors, James M Flanagan.
Epigenetics, 2016 Jan 05; 10(12). PMID: 26727311    Free PMC article.
Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.
Magali Michaut, Suet-Feung Chin, +43 authors, Rene Bernards.
Sci Rep, 2016 Jan 06; 6. PMID: 26729235    Free PMC article.
Highly Cited.
Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines.
Sarah Franco Vieira de Oliveira, Monica Ganzinelli, +9 authors, Enilze Maria de Souza Fonseca Ribeiro.
PLoS One, 2016 Jan 12; 11(1). PMID: 26751376    Free PMC article.
Exploring circulating micro-RNA in the neoadjuvant treatment of breast cancer.
Máire-Caitlín Casey, Karl J Sweeney, James Andrew Lawrence Brown, Michael J Kerin.
Int J Cancer, 2016 Jan 13; 139(1). PMID: 26756433    Free PMC article.
Review.
Iteratively refining breast cancer intrinsic subtypes in the METABRIC dataset.
Heloisa H Milioli, Renato Vimieiro, +3 authors, Pablo Moscato.
BioData Min, 2016 Jan 16; 9. PMID: 26770261    Free PMC article.
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
Richard Marcotte, Azin Sayad, +10 authors, Benjamin G Neel.
Cell, 2016 Jan 16; 164(1-2). PMID: 26771497    Free PMC article.
Highly Cited.
Model Comparison for Breast Cancer Prognosis Based on Clinical Data.
Sabri Boughorbel, Rashid Al-Ali, Naser Elkum.
PLoS One, 2016 Jan 16; 11(1). PMID: 26771838    Free PMC article.
Cell-free circulating tumour DNA as a liquid biopsy in breast cancer.
Leticia De Mattos-Arruda, Carlos Caldas.
Mol Oncol, 2016 Jan 19; 10(3). PMID: 26776681    Free PMC article.
Review.
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer.
David N Brown, Irene Caffa, +7 authors, Gabriele Zoppoli.
Sci Rep, 2016 Jan 19; 6. PMID: 26777065    Free PMC article.
Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.
Ellen Heitzer, Peter Ulz, Jochen B Geigl, Michael R Speicher.
Mol Oncol, 2016 Jan 19; 10(3). PMID: 26778171    Free PMC article.
Review.
Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer.
Sharon Wang, Jeff C Liu, +2 authors, Eldad Zacksenhaus.
Breast Cancer Res, 2016 Jan 20; 18(1). PMID: 26781438    Free PMC article.
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes.
Terri L Messier, Jonathan A R Gordon, +5 authors, Gary S Stein.
Oncotarget, 2016 Jan 20; 7(5). PMID: 26783963    Free PMC article.
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.
Qin Tang, John C Moore, +10 authors, David M Langenau.
Nat Commun, 2016 Jan 23; 7. PMID: 26790525    Free PMC article.
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations.
Elena Guerini-Rocco, Salvatore Piscuoglio, +15 authors, Jorge S Reis-Filho.
J Pathol, 2016 Jan 26; 238(5). PMID: 26806567    Free PMC article.
Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production.
Vytautas Leoncikas, Huihai Wu, +2 authors, Nick J Plant.
Sci Rep, 2016 Jan 28; 6. PMID: 26813959    Free PMC article.
Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression.
Salvatore Piscuoglio, Charlotte Ky Ng, +23 authors, Jorge S Reis-Filho.
J Pathol, 2016 Feb 03; 238(4). PMID: 26832993    Free PMC article.
Prediction of clinical phenotypes in invasive breast carcinomas from the integration of radiomics and genomics data.
Wentian Guo, Hui Li, +9 authors, Tcga Breast Phenotype Research Group.
J Med Imaging (Bellingham), 2016 Feb 03; 2(4). PMID: 26835491    Free PMC article.
Highly Cited.
G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program.
Christina Y Yim, David J Sekula, +6 authors, Michael J Spinella.
Cancer Res, 2016 Feb 04; 76(5). PMID: 26837760    Free PMC article.
Cross-platform normalization of microarray and RNA-seq data for machine learning applications.
Jeffrey A Thompson, Jie Tan, Casey S Greene.
PeerJ, 2016 Feb 05; 4. PMID: 26844019    Free PMC article.
Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome.
Linlin Luo, Peter McGarvey, +3 authors, Geeta Upadhyay.
Oncotarget, 2016 Feb 11; 7(10). PMID: 26862846    Free PMC article.
Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.
Michelle Goldsworthy, Ying Bai, +10 authors, Roger D Cox.
Diabetes, 2016 Feb 13; 65(5). PMID: 26868295    Free PMC article.
Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients.
Yanfeng Zhang, Qiuyin Cai, +4 authors, Jirong Long.
J Mol Genet Med, 2016 Feb 13; 9(4). PMID: 26870154    Free PMC article.
Collateral Lethality: A new therapeutic strategy in oncology.
Florian L Muller, Elisa A Aquilanti, Ronald A DePinho.
Trends Cancer, 2016 Feb 13; 1(3). PMID: 26870836    Free PMC article.
Highly Cited.
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
D Y Kim, D M Helfman.
Oncogene, 2016 Feb 16; 35(34). PMID: 26876209
Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer.
I-Chun Chen, Yuan-Ching Chang, +11 authors, Ann-Lii Cheng.
Sci Rep, 2016 Feb 16; 6. PMID: 26877155    Free PMC article.
The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks.
Karina Vázquez-Arreguín, Dean Tantin.
Biochim Biophys Acta, 2016 Feb 16; 1859(6). PMID: 26877236    Free PMC article.
Review.
Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis.
Rachael Natrajan, Heba Sailem, +5 authors, Yinyin Yuan.
PLoS Med, 2016 Feb 18; 13(2). PMID: 26881778    Free PMC article.
Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.
H Raza Ali, Aliakbar Dariush, +16 authors, Carlos Caldas.
Breast Cancer Res, 2016 Feb 18; 18(1). PMID: 26882907    Free PMC article.
Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate.
Xiaoyun Tang, Yuan Y Zhao, +2 authors, David N Brindley.
J Lipid Res, 2016 Feb 18; 57(4). PMID: 26884614    Free PMC article.
Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients.
Ovidiu Balacescu, Loredana Balacescu, +9 authors, Ioana Berindan-Neagoe.
Mediators Inflamm, 2016 Feb 18; 2016. PMID: 26884644    Free PMC article.
Precision Medicine and Non-Colorectal Cancer Liver Metastases: Fiction or Reality?
Effie Liakopoulou, Alexander Knuth.
Viszeralmedizin, 2016 Feb 19; 31(6). PMID: 26889147    Free PMC article.
Review.
Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.
T Chernova, X M Sun, +13 authors, M MacFarlane.
Cell Death Differ, 2016 Feb 20; 23(7). PMID: 26891694    Free PMC article.
The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression.
Jonathan H Shepherd, Ivan P Uray, +4 authors, Powel H Brown.
Oncotarget, 2016 Feb 20; 7(11). PMID: 26894864    Free PMC article.
Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers.
Vidhu Sharma, Lisa Young, +3 authors, Reproducibility Project Cancer Biology.
Elife, 2016 Feb 20; 5. PMID: 26894955    Free PMC article.
Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment.
Jan Budczies, Nicole Pfarr, +10 authors, Carsten Denkert.
Oncotarget, 2016 Feb 26; 7(11). PMID: 26910888    Free PMC article.
Leukaemia 'firsts' in cancer research and treatment.
Mel Greaves.
Nat Rev Cancer, 2016 Feb 26; 16(3). PMID: 26911190
Review.
SynTarget: an online tool to test the synergetic effect of genes on survival outcome in cancer.
I Amelio, P O Tsvetkov, +3 authors, A V Antonov.
Cell Death Differ, 2016 Feb 27; 23(5). PMID: 26915292    Free PMC article.
Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers.
Bhavna S Paratala, Sonia C Dolfi, +3 authors, Kim M Hirshfield.
Biomark Cancer, 2016 Feb 27; 8(Supple 1). PMID: 26917980    Free PMC article.
Review.
Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.
Petra den Hollander, Kathryn Rawls, +9 authors, Powel H Brown.
Cancer Res, 2016 Feb 28; 76(7). PMID: 26921331    Free PMC article.
An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.
Karolina Holm, Johan Staaf, +9 authors, Markus Ringnér.
Breast Cancer Res, 2016 Mar 01; 18(1). PMID: 26923702    Free PMC article.
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Alison M Dunning, Kyriaki Michailidou, +249 authors, Stacey L Edwards.
Nat Genet, 2016 Mar 02; 48(4). PMID: 26928228    Free PMC article.
Highly Cited.
Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis.
H Bonsang-Kitzis, B Sadacca, +4 authors, F Reyal.
Oncoimmunology, 2016 Mar 05; 5(1). PMID: 26942074    Free PMC article.
Transcriptomic analysis of human breast cancer cells reveals differentially expressed genes and related cellular functions and pathways in response to gold nanorods.
Teng Zhou, Yipeng Du, Taotao Wei.
Biophys Rep, 2015 Jan 01; 1. PMID: 26942225    Free PMC article.
MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.
Andrew R Green, Mohammed A Aleskandarany, +9 authors, Emad A Rakha.
Br J Cancer, 2016 Mar 10; 114(8). PMID: 26954716    Free PMC article.
A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells.
Emmanouil Papadakis, Natalia Robson, +10 authors, Ramsey Cutress.
Oncotarget, 2016 Mar 10; 7(14). PMID: 26958811    Free PMC article.
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.
Raghavendra A Shamanna, Huiming Lu, +8 authors, Vilhelm A Bohr.
Oncotarget, 2016 Mar 10; 7(12). PMID: 26959889    Free PMC article.
The Genomic Landscape of Male Breast Cancers.
Salvatore Piscuoglio, Charlotte K Y Ng, +19 authors, Jorge S Reis-Filho.
Clin Cancer Res, 2016 Mar 11; 22(16). PMID: 26960396    Free PMC article.
Aggressive breast cancer in western Kenya has early onset, high proliferation, and immune cell infiltration.
Rispah T Sawe, Maggie Kerper, +12 authors, Laurie E Littlepage.
BMC Cancer, 2016 Mar 12; 16. PMID: 26964534    Free PMC article.
Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects.
Federica Mori, Maria Ferraiuolo, +9 authors, Sabrina Strano.
Oncotarget, 2016 Mar 12; 7(15). PMID: 26967561    Free PMC article.
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.
Elizabeth A Stanford, Zhongyan Wang, +7 authors, David H Sherr.
BMC Biol, 2016 Mar 18; 14. PMID: 26984638    Free PMC article.
p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer.
I Amelio, R A Knight, +2 authors, A V Antonov.
Cell Death Dis, 2016 Mar 18; 7. PMID: 26986515    Free PMC article.
Predicting chemoinsensitivity in breast cancer with 'omics/digital pathology data fusion.
Richard S Savage, Yinyin Yuan.
R Soc Open Sci, 2016 Mar 22; 3(2). PMID: 26998311    Free PMC article.
Identification of ganglioside GM2 activator playing a role in cancer cell migration through proteomic analysis of breast cancer secretomes.
Jihye Shin, Gamin Kim, +7 authors, Cheolju Lee.
Cancer Sci, 2016 Mar 24; 107(6). PMID: 27002480    Free PMC article.
Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells.
Liangqiang He, Yongzhe Ren, +12 authors, Zi-Chun Hua.
Oncotarget, 2016 Mar 26; 7(17). PMID: 27013580    Free PMC article.
The voltage gated Ca(2+)-channel Cav3.2 and therapeutic responses in breast cancer.
Elena Pera, Elke Kaemmerer, +7 authors, Gregory R Monteith.
Cancer Cell Int, 2016 Apr 02; 16. PMID: 27034617    Free PMC article.
A dried blood spot mass spectrometry metabolomic approach for rapid breast cancer detection.
Qingjun Wang, Tao Sun, +6 authors, Zhitu Zhu.
Onco Targets Ther, 2016 Apr 05; 9. PMID: 27042107    Free PMC article.
Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers.
William M Strauss, Chris Carter, +11 authors, Massimo Cristofanilli.
Oncotarget, 2016 Apr 07; 7(18). PMID: 27049831    Free PMC article.
Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.
S A Black, A C Nelson, +2 authors, T R Lyons.
Oncogene, 2016 Apr 12; 35(39). PMID: 27065336    Free PMC article.
High-dimensional genomic data bias correction and data integration using MANCIE.
Chongzhi Zang, Tao Wang, +11 authors, X Shirley Liu.
Nat Commun, 2016 Apr 14; 7. PMID: 27072482    Free PMC article.
An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.
Ling Bai, Howard H Yang, +8 authors, Kent W Hunter.
PLoS Genet, 2016 Apr 14; 12(4). PMID: 27074153    Free PMC article.
The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
Olga Aprelikova, Kenny Chen, +7 authors, Jeffrey E Green.
Clin Epigenetics, 2016 Apr 16; 8. PMID: 27081402    Free PMC article.
Signatures of breast cancer metastasis at a glance.
George S Karagiannis, Sumanta Goswami, +2 authors, John S Condeelis.
J Cell Sci, 2016 Apr 17; 129(9). PMID: 27084578    Free PMC article.
Review.
Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics.
Erdogan Taskesen, Sjoerd M H Huisman, +6 authors, Marcel J T Reinders.
Sci Rep, 2016 Apr 26; 6. PMID: 27109935    Free PMC article.
Nuclear tristetraprolin acts as a corepressor of multiple steroid nuclear receptors in breast cancer cells.
Tonatiuh Barrios-García, Vania Gómez-Romero, +2 authors, Alfonso León-Del-Río.
Mol Genet Metab Rep, 2016 Apr 27; 7. PMID: 27114912    Free PMC article.
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients.
Amos Kirilovsky, Florence Marliot, +3 authors, Franck Pagès.
Int Immunol, 2016 Apr 29; 28(8). PMID: 27121213    Free PMC article.
Highly Cited. Review.
Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.
Tesa M Severson, Ekaterina Nevedomskaya, +14 authors, Wilbert Zwart.
Oncotarget, 2016 Apr 30; 7(23). PMID: 27129152    Free PMC article.
TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting.
George Fountzilas, Eleni Giannoulatou, +21 authors, Vassiliki Kotoula.
Oncotarget, 2016 Apr 30; 7(22). PMID: 27129168    Free PMC article.
ICM: a web server for integrated clustering of multi-dimensional biomedical data.
Song He, Haochen He, +5 authors, Xiaochen Bo.
Nucleic Acids Res, 2016 May 02; 44(W1). PMID: 27131784    Free PMC article.
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
Serena Nik-Zainal, Helen Davies, +85 authors, Michael R Stratton.
Nature, 2016 May 03; 534(7605). PMID: 27135926    Free PMC article.
Highly Cited.
Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.
Adam D Pfefferle, Yash N Agrawal, +5 authors, Charles M Perou.
Dis Model Mech, 2016 May 07; 9(7). PMID: 27149990    Free PMC article.
GenomeRunner web server: regulatory similarity and differences define the functional impact of SNP sets.
Mikhail G Dozmorov, Lukas R Cara, Cory B Giles, Jonathan D Wren.
Bioinformatics, 2016 May 07; 32(15). PMID: 27153607    Free PMC article.
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.
Bernard Pereira, Suet-Feung Chin, +31 authors, Carlos Caldas.
Nat Commun, 2016 May 11; 7. PMID: 27161491    Free PMC article.
Highly Cited.
Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer.
Didier Meseure, Sophie Vacher, +10 authors, Ivan Bieche.
Br J Cancer, 2016 May 14; 114(12). PMID: 27172249    Free PMC article.
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Thomas Welte, Ik Sun Kim, +23 authors, Xiang H-F Zhang.
Nat Cell Biol, 2016 May 18; 18(6). PMID: 27183469    Free PMC article.
Highly Cited.
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease.
Giampaolo Bianchini, Justin M Balko, +2 authors, Luca Gianni.
Nat Rev Clin Oncol, 2016 Oct 19; 13(11). PMID: 27184417    Free PMC article.
Highly Cited. Review.
The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma.
Xiao-Chen Li, Chenglin Liu, Tao Huang, Yang Zhong.
Biomed Res Int, 2016 May 18; 2016. PMID: 27190992    Free PMC article.
Practical aspects of NGS-based pathways analysis for personalized cancer science and medicine.
Ekaterina A Kotelnikova, Mikhail Pyatnitskiy, +2 authors, Dmitriy Vinogradov.
Oncotarget, 2016 May 19; 7(32). PMID: 27191992    Free PMC article.
Review.
Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance.
Luis Manso, Silvana Mourón, +8 authors, Miguel Quintela-Fandino.
PLoS One, 2016 May 20; 11(5). PMID: 27195705    Free PMC article.
Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.
Midrar AlHossiny, Linlin Luo, +8 authors, Geeta Upadhyay.
Cancer Res, 2016 May 20; 76(11). PMID: 27197181    Free PMC article.
A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis.
Mckenna Longacre, Nicole A Snyder, +5 authors, Sibaji Sarkar.
Int J Mol Sci, 2016 May 24; 17(5). PMID: 27213343    Free PMC article.
Review.
Does Biology Transcend the Symptom-based Boundaries of Psychosis?
Godfrey D Pearlson, Brett A Clementz, +2 authors, Carol A Tamminga.
Psychiatr Clin North Am, 2016 May 25; 39(2). PMID: 27216897    Free PMC article.
Review.
Discovering causal interactions using Bayesian network scoring and information gain.
Zexian Zeng, Xia Jiang, Richard Neapolitan.
BMC Bioinformatics, 2016 May 28; 17(1). PMID: 27230078    Free PMC article.
A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer.
Katherine A Bolton, Elizabeth G Holliday, +3 authors, Rodney J Scott.
BMC Res Notes, 2016 May 28; 9. PMID: 27230222    Free PMC article.
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Wei Xiong Wen, Jaslyn Sian-Siu Soo, +9 authors, Soo Hwang Teo.
Breast Cancer Res, 2016 May 29; 18(1). PMID: 27233495    Free PMC article.
FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness.
Thomas M Campbell, Mauro A A Castro, +5 authors, Kerstin B Meyer.
Carcinogenesis, 2016 May 29; 37(8). PMID: 27236187    Free PMC article.
Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors.
Anissa Belkaid, Miroslava Čuperlović-Culf, +2 authors, Marc E Surette.
Metabolites, 2016 May 31; 6(2). PMID: 27240414    Free PMC article.
Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer.
Mahdieh Jadaliha, Xinying Zong, +8 authors, Kannanganattu V Prasanth.
Oncotarget, 2016 Oct 27; 7(26). PMID: 27250026    Free PMC article.
Highly Cited.
Proteogenomics connects somatic mutations to signalling in breast cancer.
Philipp Mertins, D R Mani, +34 authors, NCI CPTAC.
Nature, 2016 Jun 03; 534(7605). PMID: 27251275    Free PMC article.
Highly Cited.
Breast cancer subtype predictors revisited: from consensus to concordance?
Herman M J Sontrop, Marcel J T Reinders, Perry D Moerland.
BMC Med Genomics, 2016 Jun 05; 9(1). PMID: 27259591    Free PMC article.
Diagnostic and prognostic significance of serum apolipoprotein C-I in triple-negative breast cancer based on mass spectrometry.
Dongjian Song, Lifang Yue, +15 authors, Jiaxiang Wang.
Cancer Biol Ther, 2016 Jun 05; 17(6). PMID: 27260686    Free PMC article.
Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.
Nicole S Spoelstra, Diana M Cittelly, +4 authors, Jennifer K Richer.
Hum Pathol, 2016 Jun 05; 56. PMID: 27260947    Free PMC article.
Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway.
Ae Lee Jeong, Sora Han, +7 authors, Young Yang.
Sci Rep, 2016 Jun 09; 6. PMID: 27272709    Free PMC article.
Global, quantitative and dynamic mapping of protein subcellular localization.
Daniel N Itzhak, Stefka Tyanova, Jürgen Cox, Georg Hh Borner.
Elife, 2016 Jun 10; 5. PMID: 27278775    Free PMC article.
Highly Cited.
Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer.
Hetal Patel, Rezvan Abduljabbar, +20 authors, Simak Ali.
Clin Cancer Res, 2016 Nov 04; 22(23). PMID: 27301701    Free PMC article.
HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.
Helen Sadik, Preethi Korangath, +15 authors, Saraswati Sukumar.
Cancer Res, 2016 Jun 16; 76(15). PMID: 27302171    Free PMC article.
HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.
Sylvia Mahara, Puay Leng Lee, +3 authors, Qiang Yu.
Proc Natl Acad Sci U S A, 2016 Jun 16; 113(26). PMID: 27303043    Free PMC article.
Approaches to uncovering cancer diagnostic and prognostic molecular signatures.
Shengjun Hong, Yi Huang, +2 authors, Jing-Dong J Han.
Mol Cell Oncol, 2014 Apr 01; 1(2). PMID: 27308330    Free PMC article.
Moving ahead on harnessing synthetic lethality to fight cancer.
Livnat Jerby-Arnon, Eytan Ruppin.
Mol Cell Oncol, 2015 Apr 01; 2(2). PMID: 27308440    Free PMC article.
Meta-analytic framework for sparse K-means to identify disease subtypes in multiple transcriptomic studies.
Zhiguang Huo, Ying Ding, +2 authors, George Tseng.
J Am Stat Assoc, 2016 Jun 23; 111(513). PMID: 27330233    Free PMC article.
Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism.
Haseeb Zubair, Shafquat Azim, +5 authors, Aamir Ahmad.
Int J Mol Sci, 2016 Jun 23; 17(5). PMID: 27331811    Free PMC article.
Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.
Clara Andradas, Sandra Blasco-Benito, +21 authors, Cristina Sánchez.
Oncotarget, 2016 Jun 25; 7(30). PMID: 27340777    Free PMC article.
Extensive Transcriptomic and Genomic Analysis Provides New Insights about Luminal Breast Cancers.
Inna Tishchenko, Heloisa Helena Milioli, Carlos Riveros, Pablo Moscato.
PLoS One, 2016 Jun 25; 11(6). PMID: 27341628    Free PMC article.
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
Mi-Ryung Han, Jirong Long, +28 authors, Wei Zheng.
Hum Mol Genet, 2016 Jun 30; 25(15). PMID: 27354352    Free PMC article.
Robust Bayesian Fluorescence Lifetime Estimation, Decay Model Selection and Instrument Response Determination for Low-Intensity FLIM Imaging.
Mark I Rowley, Anthonius C C Coolen, Borivoj Vojnovic, Paul R Barber.
PLoS One, 2016 Jun 30; 11(6). PMID: 27355322    Free PMC article.
Algorithmic methods to infer the evolutionary trajectories in cancer progression.
Giulio Caravagna, Alex Graudenzi, +6 authors, Bud Mishra.
Proc Natl Acad Sci U S A, 2016 Jul 01; 113(28). PMID: 27357673    Free PMC article.
Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers: a large-scale analysis of fresh frozen tissue samples.
Sofia Waldemarson, Emila Kurbasic, +4 authors, Peter James.
Breast Cancer Res, 2016 Jul 01; 18(1). PMID: 27357824    Free PMC article.
Effect of low doses of estradiol and tamoxifen on breast cancer cell karyotypes.
Milena Rondón-Lagos, Nelson Rangel, +6 authors, Anna Sapino.
Endocr Relat Cancer, 2016 Jul 01; 23(8). PMID: 27357940    Free PMC article.
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
Syed Haider, Alan McIntyre, +4 authors, Francesca M Buffa.
Genome Biol, 2016 Jul 01; 17(1). PMID: 27358048    Free PMC article.
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
Zhi Hu, Jian-Hua Mao, +22 authors, Joe W Gray.
Breast Cancer Res, 2016 Jul 03; 18(1). PMID: 27368372    Free PMC article.
Kataegis Expression Signature in Breast Cancer Is Associated with Late Onset, Better Prognosis, and Higher HER2 Levels.
Matteo D'Antonio, Pablo Tamayo, Jill P Mesirov, Kelly A Frazer.
Cell Rep, 2016 Jul 05; 16(3). PMID: 27373164    Free PMC article.
ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways.
Ling Tan, Xiaodan Song, +3 authors, Zhijun Sun.
Oncotarget, 2016 Jul 05; 7(29). PMID: 27374177    Free PMC article.
The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase.
Klaus P Hoeflich, Jane Guan, +6 authors, Jeffrey J Wallin.
Genes Cancer, 2016 Jul 07; 7(3-4). PMID: 27382432    Free PMC article.
Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.
Libero Santarpia, Giulia Bottai, +3 authors, Lajos Pusztai.
Oncologist, 2016 Jul 08; 21(9). PMID: 27384237    Free PMC article.
Review.
Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.
Hari Singhal, Marianne E Greene, +10 authors, Geoffrey L Greene.
Sci Adv, 2016 Jul 08; 2(6). PMID: 27386569    Free PMC article.
Expression and methylation patterns partition luminal-A breast tumors into distinct prognostic subgroups.
Dvir Netanely, Ayelet Avraham, +2 authors, Ron Shamir.
Breast Cancer Res, 2016 Jul 09; 18(1). PMID: 27386846    Free PMC article.
Wars2 is a determinant of angiogenesis.
Mao Wang, Patrick Sips, +25 authors, Stuart A Cook.
Nat Commun, 2016 Jul 09; 7. PMID: 27389904    Free PMC article.
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Abhijit Mazumdar, Graham M Poage, +11 authors, Powel H Brown.
Breast Cancer Res Treat, 2016 Jul 10; 158(3). PMID: 27393618    Free PMC article.
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers.
Anthony Ferrari, Anne Vincent-Salomon, +40 authors, Gilles Thomas.
Nat Commun, 2016 Jul 14; 7. PMID: 27406316    Free PMC article.
A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer.
Noam Auslander, Keren Yizhak, +5 authors, Eytan Ruppin.
Sci Rep, 2016 Jul 14; 6. PMID: 27406679    Free PMC article.
Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors.
M Wassef, A Michaud, R Margueron.
Cell Cycle, 2016 Jul 16; 15(17). PMID: 27419533    Free PMC article.
miR-206 Inhibits Stemness and Metastasis of Breast Cancer by Targeting MKL1/IL11 Pathway.
Ravand Samaeekia, Valery Adorno-Cruz, +11 authors, Huiping Liu.
Clin Cancer Res, 2016 Jul 21; 23(4). PMID: 27435395    Free PMC article.
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
Rohith Srivas, John Paul Shen, +17 authors, Trey Ideker.
Mol Cell, 2016 Jul 28; 63(3). PMID: 27453043    Free PMC article.
Highly Cited.
Prognostic factor analysis for breast cancer using gene expression profiles.
Soobok Joe, Hojung Nam.
BMC Med Inform Decis Mak, 2016 Jul 28; 16 Suppl 1. PMID: 27454576    Free PMC article.
New generation of breast cancer clinical trials implementing molecular profiling.
Dimitrios Zardavas, Martine Piccart-Gebhart.
Cancer Biol Med, 2016 Jul 28; 13(2). PMID: 27458530    Free PMC article.
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Chenjie Zeng, Xingyi Guo, +239 authors, Wei Zheng.
Breast Cancer Res, 2016 Jul 28; 18(1). PMID: 27459855    Free PMC article.
An investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer.
Bin Zhu, Anwesha Mukherjee, +6 authors, Nilanjan Chatterjee.
Br J Cancer, 2016 Jul 29; 115(6). PMID: 27467053    Free PMC article.
Major milestones in translational oncology.
Tommaso A Dragani, Antoni Castells, +6 authors, Jack A Schalken.
BMC Med, 2016 Jul 30; 14(1). PMID: 27469586    Free PMC article.
Spatial Heterogeneity in the Tumor Microenvironment.
Yinyin Yuan.
Cold Spring Harb Perspect Med, 2016 Aug 03; 6(8). PMID: 27481837    Free PMC article.
Review.
Statistical Methods in Integrative Genomics.
Sylvia Richardson, George C Tseng, Wei Sun.
Annu Rev Stat Appl, 2016 Aug 03; 3. PMID: 27482531    Free PMC article.
Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma.
Renata A Canevari, Fabio A Marchi, +5 authors, Eduardo M Reis.
Tumour Biol, 2016 Aug 04; 37(10). PMID: 27485113
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.
Aldema Sas-Chen, Miriam R Aure, +17 authors, Yosef Yarden.
EMBO Mol Med, 2016 Aug 04; 8(9). PMID: 27485121    Free PMC article.
Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer.
Nicola Fusco, Felipe C Geyer, +18 authors, Britta Weigelt.
Mod Pathol, 2016 Oct 28; 29(11). PMID: 27491809    Free PMC article.
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Adam Shlien, Keiran Raine, +35 authors, Peter J Campbell.
Cell Rep, 2016 Aug 09; 16(7). PMID: 27498871    Free PMC article.
Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium.
William J Howat, Fiona M Blows, +49 authors, Montserrat García-Closas.
J Pathol Clin Res, 2015 Jan 01; 1(1). PMID: 27499890    Free PMC article.
Classical pathology and mutational load of breast cancer - integration of two worlds.
Jan Budczies, Michael Bockmayr, +7 authors, Albrecht Stenzinger.
J Pathol Clin Res, 2016 Aug 09; 1(4). PMID: 27499907    Free PMC article.
The highly expressed 5'isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration.
Omar Salem, Nese Erdem, +5 authors, Cindy Körner.
BMC Genomics, 2016 Aug 10; 17. PMID: 27502506    Free PMC article.
Somatic TP53 Mutations in the Era of Genome Sequencing.
Pierre Hainaut, Gerd P Pfeifer.
Cold Spring Harb Perspect Med, 2016 Nov 03; 6(11). PMID: 27503997    Free PMC article.
Review.
Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.
Sarah L Maguire, Barrie Peck, +10 authors, Rachael Natrajan.
J Pathol, 2016 Oct 21; 240(3). PMID: 27512948    Free PMC article.
RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
A Rasim Barutcu, Deli Hong, +7 authors, Gary S Stein.
Biochim Biophys Acta, 2016 Oct 21; 1859(11). PMID: 27514584    Free PMC article.
AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection.
Marion Rudolph, Tobias Anzeneder, +8 authors, Joachim Reischl.
BMC Cancer, 2016 Aug 16; 16. PMID: 27515171    Free PMC article.
Hereditary breast and ovarian cancer: new genes in confined pathways.
Finn Cilius Nielsen, Thomas van Overeem Hansen, Claus Storgaard Sørensen.
Nat Rev Cancer, 2016 Aug 16; 16(9). PMID: 27515922
Highly Cited. Review.
11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes.
Lauana Greicy Tonon Lemos, Gabriela Nestal de Moraes, +6 authors, Raquel Ciuvalschi Maia.
J Cancer Res Clin Oncol, 2016 Aug 16; 142(10). PMID: 27520309
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Yubao Wang, Michael Begley, +7 authors, Jean J Zhao.
Proc Natl Acad Sci U S A, 2016 Aug 17; 113(35). PMID: 27528663    Free PMC article.
ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization.
Kinga Wrobel, Yiru Chen Zhao, +10 authors, Zeynep Madak-Erdogan.
Mol Endocrinol, 2016 Aug 18; 30(10). PMID: 27533791    Free PMC article.
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.
K Tominaga, T Shimamura, +19 authors, N Gotoh.
Oncogene, 2016 Aug 23; 36(9). PMID: 27546618    Free PMC article.
Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?
Danielly C F Costa, Guilherme A P de Oliveira, +3 authors, Jerson L Silva.
Cold Spring Harb Perspect Biol, 2016 Aug 24; 8(10). PMID: 27549118    Free PMC article.
Review.
Stratification and therapeutic potential of PML in metastatic breast cancer.
Natalia Martín-Martín, Marco Piva, +36 authors, Arkaitz Carracedo.
Nat Commun, 2016 Aug 25; 7. PMID: 27553708    Free PMC article.
Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer.
Guanglong Jiang, Shijun Zhang, +5 authors, Lijun Cheng.
BMC Genomics, 2016 Aug 25; 17 Suppl 7. PMID: 27556158    Free PMC article.
CrossLink: a novel method for cross-condition classification of cancer subtypes.
Chifeng Ma, Konduru S Sastry, +7 authors, Yufei Huang.
BMC Genomics, 2016 Aug 25; 17 Suppl 7. PMID: 27556419    Free PMC article.
Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.
Jason R Todd, Karen A Ryall, +5 authors, Paul H Huang.
Oncotarget, 2016 Aug 25; 7(39). PMID: 27556857    Free PMC article.
Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.
Swneke D Bailey, Kinjal Desai, +16 authors, Mathieu Lupien.
Nat Genet, 2016 Aug 30; 48(10). PMID: 27571262    Free PMC article.
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.
Robert A Jones, Tyler J Robinson, +15 authors, Eldad Zacksenhaus.
J Clin Invest, 2016 Aug 30; 126(10). PMID: 27571409    Free PMC article.
MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy.
Benjamin C Calhoun, Bryce Portier, +5 authors, Larry E Morrison.
BMC Cancer, 2016 Sep 01; 16. PMID: 27576528    Free PMC article.
The influence of personality and perceived stress on the development of breast cancer: 20-year follow-up of 29,098 Japanese women.
Takayuki Sawada, Takeshi Nishiyama, +6 authors, Shogo Kikuchi.
Sci Rep, 2016 Sep 03; 6. PMID: 27586560    Free PMC article.
Classification of breast cancer patients using somatic mutation profiles and machine learning approaches.
Suleyman Vural, Xiaosheng Wang, Chittibabu Guda.
BMC Syst Biol, 2016 Sep 03; 10 Suppl 3. PMID: 27587275    Free PMC article.
Elementary: breast cancer culprits leave their signatures on the double helix.
Delphine Merino, Bhupinder Pal, Anthony T Papenfuss.
Cell Death Differ, 2016 Sep 03; 23(10). PMID: 27588706    Free PMC article.
Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.
Barbara Mair, Tomasz Konopka, +6 authors, Sebastian M B Nijman.
PLoS Genet, 2016 Sep 03; 12(9). PMID: 27588951    Free PMC article.
Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis.
Matthew H Ung, George L Wang, Frederick S Varn, Chao Cheng.
Oncotarget, 2016 Sep 03; 7(51). PMID: 27589846    Free PMC article.
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Hatef Darabi, Jonathan Beesley, +111 authors, Alison M Dunning.
Sci Rep, 2016 Sep 08; 6. PMID: 27600471    Free PMC article.
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Kate Lawrenson, Siddhartha Kar, +284 authors, Simon A Gayther.
Nat Commun, 2016 Sep 08; 7. PMID: 27601076    Free PMC article.
EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer.
Igor Katsyv, Minghui Wang, +6 authors, Hanna Y Irie.
Oncotarget, 2016 Sep 11; 7(43). PMID: 27612429    Free PMC article.
Subgroup-Based Adaptive (SUBA) Designs for Multi-Arm Biomarker Trials.
Yanxun Xu, Lorenzo Trippa, Peter Müller, Yuan Ji.
Stat Biosci, 2016 Sep 13; 8(1). PMID: 27617041    Free PMC article.
HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status.
Gregory Weitsman, Paul R Barber, +13 authors, Tony Ng.
Oncotarget, 2016 Sep 14; 7(32). PMID: 27618787    Free PMC article.
A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer.
Luca Malorni, Silvano Piazza, +7 authors, Ilenia Migliaccio.
Oncotarget, 2016 Oct 18; 7(42). PMID: 27634906    Free PMC article.
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Alejandra Bruna, Oscar M Rueda, +27 authors, Carlos Caldas.
Cell, 2016 Sep 20; 167(1). PMID: 27641504    Free PMC article.
Highly Cited.
ZNF703 Overexpression may act as an oncogene in non-small cell lung cancer.
Onur Baykara, Nejat Dalay, Kamil Kaynak, Nur Buyru.
Cancer Med, 2016 Oct 30; 5(10). PMID: 27650486    Free PMC article.
WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines.
Matthew J Sikora, Britta M Jacobsen, +5 authors, Steffi Oesterreich.
Breast Cancer Res, 2016 Sep 22; 18(1). PMID: 27650553    Free PMC article.
Breast cancer classification and prognostication through diverse systems along with recent emerging findings in this respect; the dawn of new perspectives in the clinical applications.
Vida Pourteimoor, Samira Mohammadi-Yeganeh, Mahdi Paryan.
Tumour Biol, 2016 Sep 22; 37(11). PMID: 27651157
Review.
Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer.
Min Soo Kim, Joon Jeong, +3 authors, Wook Jin.
Sci Rep, 2016 Sep 23; 6. PMID: 27654855    Free PMC article.
Cancer Cell Fusion: Mechanisms Slowly Unravel.
Felicite K Noubissi, Brenda M Ogle.
Int J Mol Sci, 2016 Sep 23; 17(9). PMID: 27657058    Free PMC article.
Review.
Renewed interest in the progesterone receptor in breast cancer.
Elgene Lim, Carlo Palmieri, Wayne D Tilley.
Br J Cancer, 2016 Sep 23; 115(8). PMID: 27657336    Free PMC article.
PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells.
Jessica Byerly, Gwyneth Halstead-Nussloch, +2 authors, Hanna Y Irie.
Breast Cancer Res, 2016 Sep 25; 18(1). PMID: 27663795    Free PMC article.
Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer.
Chao Liu, Florian Rohart, +3 authors, Kim-Anh Lê Cao.
Sci Rep, 2016 Sep 27; 6. PMID: 27666291    Free PMC article.
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Marcel Smid, F Germán Rodríguez-González, +44 authors, John W M Martens.
Nat Commun, 2016 Sep 27; 7. PMID: 27666519    Free PMC article.
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression.
Yashar S Niknafs, Sumin Han, +25 authors, Felix Y Feng.
Nat Commun, 2016 Sep 27; 7. PMID: 27666543    Free PMC article.
Highly Cited.
Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes.
Andriy Marusyk, Doris P Tabassum, +17 authors, Kornelia Polyak.
Cancer Res, 2016 Nov 05; 76(22). PMID: 27671678    Free PMC article.
Data-Driven Metabolic Pathway Compositions Enhance Cancer Survival Prediction.
Noam Auslander, Allon Wagner, Matthew Oberhardt, Eytan Ruppin.
PLoS Comput Biol, 2016 Sep 28; 12(9). PMID: 27673682    Free PMC article.
Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.
Jin-Ah Kim, Ying Tan, +9 authors, Xiao-Song Wang.
Nat Commun, 2016 Oct 04; 7. PMID: 27694828    Free PMC article.
Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.
C S Daly, P Shaw, +7 authors, K R Reed.
Oncogene, 2016 Oct 04; 36(13). PMID: 27694902    Free PMC article.
Patient-derived tumour xenografts for breast cancer drug discovery.
John W Cassidy, Ankita S Batra, Wendy Greenwood, Alejandra Bruna.
Endocr Relat Cancer, 2016 Oct 22; 23(12). PMID: 27702751    Free PMC article.
Review.
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family.
Felipe C Geyer, Samuel H Berman, +13 authors, Jorge S Reis-Filho.
Mod Pathol, 2016 Oct 08; 30(1). PMID: 27713419    Free PMC article.
Ion channels expression and function are strongly modified in solid tumors and vascular malformations.
Antonella Biasiotta, Daniela D'Arcangelo, +2 authors, Antonio Facchiano.
J Transl Med, 2016 Oct 08; 14(1). PMID: 27716384    Free PMC article.
Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?
Ewa M Michalak, Jane E Visvader.
Mol Oncol, 2016 Oct 09; 10(10). PMID: 27717710    Free PMC article.
Review.
Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.
Songjian Lu, Chunhui Cai, +9 authors, Xinghua Lu.
Cancer Res, 2016 Oct 21; 76(23). PMID: 27758891    Free PMC article.
Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells.
Lydia Edjekouane, Samira Benhadjeba, +4 authors, André Tremblay.
Oncotarget, 2016 Oct 21; 7(47). PMID: 27764788    Free PMC article.
Targeted NGS, array-CGH, and patient-derived tumor xenografts for precision medicine in advanced breast cancer: a single-center prospective study.
Anthony Gonçalves, François Bertucci, +23 authors, Daniel Birnbaum.
Oncotarget, 2016 Oct 22; 7(48). PMID: 27765906    Free PMC article.
Triple-negative breast cancer: is there a treatment on the horizon?
Hui Yao, Guangchun He, +4 authors, Xiyun Deng.
Oncotarget, 2016 Oct 22; 8(1). PMID: 27765921    Free PMC article.
Highly Cited. Review.
Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients.
Barbara Wolf, Georg Goebel, Hubert Hackl, Heidi Fiegl.
BMC Cancer, 2016 Oct 25; 16(1). PMID: 27770790    Free PMC article.
A Novel Graph-based Algorithm to Infer Recurrent Copy Number Variations in Cancer.
Chen Chi, Rasif Ajwad, Qin Kuang, Pingzhao Hu.
Cancer Inform, 2016 Oct 25; 15(Suppl 2). PMID: 27773988    Free PMC article.
Progress in the clinical detection of heterogeneity in breast cancer.
Jun-Long Song, Chuang Chen, Jing-Ping Yuan, Sheng-Rong Sun.
Cancer Med, 2016 Oct 25; 5(12). PMID: 27774765    Free PMC article.
Review.
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Fara Brasó-Maristany, Simone Filosto, +25 authors, Andrew N Tutt.
Nat Med, 2016 Nov 01; 22(11). PMID: 27775704    Free PMC article.
Highly Cited.
Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer.
Yue Wang, Kenneth M K Mark, +6 authors, Chao Cheng.
Genome Med, 2016 Oct 30; 8(1). PMID: 27788678    Free PMC article.
Mammary gland stem cells and their application in breast cancer.
Xing Yang, Hui Wang, Baowei Jiao.
Oncotarget, 2016 Oct 30; 8(6). PMID: 27793013    Free PMC article.
Review.
Rawcopy: Improved copy number analysis with Affymetrix arrays.
Markus Mayrhofer, Björn Viklund, Anders Isaksson.
Sci Rep, 2016 Nov 01; 6. PMID: 27796336    Free PMC article.
Biopsy variability of lymphocytic infiltration in breast cancer subtypes and the ImmunoSkew score.
Adnan Mujahid Khan, Yinyin Yuan.
Sci Rep, 2016 Nov 05; 6. PMID: 27812028    Free PMC article.
HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.
Nicolas Vince, Hongchuan Li, +7 authors, Mary Carrington.
Am J Hum Genet, 2016 Nov 08; 99(6). PMID: 27817866    Free PMC article.
PIN1 in breast development and cancer: a clinical perspective.
Alessandra Rustighi, Alessandro Zannini, +3 authors, Giannino Del Sal.
Cell Death Differ, 2016 Nov 12; 24(2). PMID: 27834957    Free PMC article.
Review.
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.
Arvind Arora, Swetha Parvathaneni, +9 authors, Srinivasan Madhusudan.
Mol Cancer Ther, 2016 Nov 12; 16(1). PMID: 27837030    Free PMC article.
Recent developments and translational aspects in targeted therapy for metastatic breast cancer.
Maximilian Marhold, Rupert Bartsch, Christoph Zielinski.
ESMO Open, 2016 Nov 16; 1(3). PMID: 27843605    Free PMC article.
Review.
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.
Roberto Rangel, Song-Choon Lee, +12 authors, Neal G Copeland.
Proc Natl Acad Sci U S A, 2016 Nov 17; 113(48). PMID: 27849608    Free PMC article.
One microenvironment does not fit all: heterogeneity beyond cancer cells.
Ik Sun Kim, Xiang H-F Zhang.
Cancer Metastasis Rev, 2016 Nov 20; 35(4). PMID: 27858305    Free PMC article.
Review.
Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.
Gabriele Corda, Gianluca Sala, +22 authors, Arturo Sala.
J Pathol, 2016 Nov 20; 241(3). PMID: 27859262    Free PMC article.
The molecular basis of breast cancer pathological phenotypes.
Yujing J Heng, Susan C Lester, +26 authors, Andrew H Beck.
J Pathol, 2016 Nov 20; 241(3). PMID: 27861902    Free PMC article.
Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis.
Yan Zhou, Pei Wang, +2 authors, Peter X-K Song.
Genet Epidemiol, 2016 Nov 20; 41(1). PMID: 27862229    Free PMC article.
Unique epigenetic gene profiles define human breast cancers with poor prognosis.
Samuel Peña-Llopis, Yihong Wan, Elisabeth D Martinez.
Oncotarget, 2016 Nov 20; 7(52). PMID: 27863398    Free PMC article.
Systems Approaches to Cancer Biology.
Tenley C Archer, Elana J Fertig, +6 authors, Ayesha N Shajahan-Haq.
Cancer Res, 2016 Nov 20; 76(23). PMID: 27864348    Free PMC article.
Identification of clinically predictive metagenes that encode components of a network coupling cell shape to transcription by image-omics.
Heba Z Sailem, Chris Bakal.
Genome Res, 2016 Nov 20; 27(2). PMID: 27864353    Free PMC article.
Trastuzumab-associated cardiac events in the Persephone trial.
Helena M Earl, Anne-Laure Vallier, +12 authors, Louise Hiller.
Br J Cancer, 2016 Nov 23; 115(12). PMID: 27875516    Free PMC article.
A systematic comparison of copy number alterations in four types of female cancer.
Fatemeh Kaveh, Lars O Baumbusch, +5 authors, Hiroko K Solvang.
BMC Cancer, 2016 Nov 24; 16(1). PMID: 27876019    Free PMC article.
Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer.
Sayem Miah, Charles A S Banks, +3 authors, Michael P Washburn.
Mol Biosyst, 2016 Nov 29; 13(1). PMID: 27891540    Free PMC article.
Review.
Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer.
L Yu, Y Liang, +6 authors, K Li.
Oncogene, 2016 Nov 29; 36(20). PMID: 27893709    Free PMC article.
The Genome Conformation As an Integrator of Multi-Omic Data: The Example of Damage Spreading in Cancer.
Fabio Tordini, Marco Aldinucci, +2 authors, Ivan Merelli.
Front Genet, 2016 Nov 30; 7. PMID: 27895661    Free PMC article.
FREQUENT SUBGRAPH MINING OF PERSONALIZED SIGNALING PATHWAY NETWORKS GROUPS PATIENTS WITH FREQUENTLY DYSREGULATED DISEASE PATHWAYS AND PREDICTS PROGNOSIS.
Arda Durmaz, Tim A D Henderson, Douglas Brubaker, Gurkan Bebek.
Pac Symp Biocomput, 2016 Nov 30; 22. PMID: 27896993    Free PMC article.
Long intergenic non-coding RNA expression signature in human breast cancer.
Yanfeng Zhang, Erin K Wagner, +5 authors, Jirong Long.
Sci Rep, 2016 Nov 30; 6. PMID: 27897201    Free PMC article.
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains.
Yang Gao, Andrew E Teschendorff.
Nucleic Acids Res, 2016 Dec 03; 45(2). PMID: 27899617    Free PMC article.
Cooperative genomic alteration network reveals molecular classification across 12 major cancer types.
Hongyi Zhang, Yulan Deng, +8 authors, Xia Li.
Nucleic Acids Res, 2016 Dec 03; 45(2). PMID: 27899621    Free PMC article.
A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse.
Aleix Prat, Ana Lluch, +22 authors, Emilio Alba.
Clin Cancer Res, 2016 Dec 03; 23(12). PMID: 27903675    Free PMC article.
sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors.
Wenhan Chen, Alan J Robertson, Devika Ganesamoorthy, Lachlan J M Coin.
Nucleic Acids Res, 2016 Dec 03; 45(5). PMID: 27903916    Free PMC article.
Detection of gene copy number alterations in DCIS and invasive breast cancer by QM-FISH.
Aifeng Pan, Yawei Zhou, +4 authors, Li Li.
Am J Transl Res, 2016 Dec 03; 8(11). PMID: 27904700    Free PMC article.
Big Data Bioinformatics.
Xue-Wen Chen, Jean X Gao.
Methods, 2016 Dec 03; 111. PMID: 27908398    Free PMC article.
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.
Thomas Fleischer, Jovana Klajic, +15 authors, Vessela N Kristensen.
Oncotarget, 2016 Dec 03; 8(1). PMID: 27911866    Free PMC article.
The genetic landscape of breast carcinomas with neuroendocrine differentiation.
Caterina Marchiò, Felipe C Geyer, +12 authors, Jorge S Reis-Filho.
J Pathol, 2016 Dec 08; 241(3). PMID: 27925203    Free PMC article.
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.
Kamila M Jozwik, Igor Chernukhin, +2 authors, Jason S Carroll.
Cell Rep, 2016 Dec 08; 17(10). PMID: 27926873    Free PMC article.
Highly Cited.
Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study.
H Raza Ali, Leon Chlon, +2 authors, Carlos Caldas.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959923    Free PMC article.
Highly Cited.
Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.
Robert Kridel, Fong Chun Chan, +29 authors, Sohrab P Shah.
PLoS Med, 2016 Dec 14; 13(12). PMID: 27959929    Free PMC article.
Highly Cited.
The transcription levels and prognostic values of seven proteasome alpha subunits in human cancers.
Yunhai Li, Jing Huang, +6 authors, Guosheng Ren.
Oncotarget, 2016 Dec 15; 8(3). PMID: 27966459    Free PMC article.
The recurrent architecture of tumour initiation, progression and drug sensitivity.
Andrea Califano, Mariano J Alvarez.
Nat Rev Cancer, 2016 Dec 16; 17(2). PMID: 27977008    Free PMC article.
Highly Cited. Review.
An mRNA Gene Expression-Based Signature to Identify FGFR1-Amplified Estrogen Receptor-Positive Breast Tumors.
Jingqin Luo, Shuzhen Liu, +11 authors, Matthew J Ellis.
J Mol Diagn, 2016 Dec 21; 19(1). PMID: 27993329    Free PMC article.
p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.
Robert A H van de Ven, Jolien S de Groot, +11 authors, Patrick W B Derksen.
Nat Commun, 2016 Dec 23; 7. PMID: 28004812    Free PMC article.
A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways.
Anne-Sophie Hamy, Hélène Bonsang-Kitzis, +7 authors, Fabien Reyal.
PLoS One, 2016 Dec 23; 11(12). PMID: 28005906    Free PMC article.
Patient-derived xenograft (PDX) models in basic and translational breast cancer research.
Lacey E Dobrolecki, Susie D Airhart, +29 authors,