Journal Article
. 2012 May; 4(134):134ra62.
doi: 10.1126/scitranslmed.3003330.

CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients

Andrew J Rech 1 Rosemarie Mick  Sunil Martin  Adri Recio  Nicole A Aqui  Daniel J Powell  Theresa A Colligon  Jennifer A Trosko  Leah I Leinbach  Charles H Pletcher  Carol K Tweed  Angela DeMichele  Kevin R Fox  Susan M Domchek  James L Riley  Robert H Vonderheide  
  • PMID: 22593175
  •     45 References
  •     133 citations


Regulatory T cells (T(regs)) are key mediators of immune tolerance and feature prominently in cancer. Depletion of CD25(+) FoxP3(+) T(regs) in vivo may promote T cell cancer immunosurveillance, but no strategy to do so in humans while preserving immunity and preventing autoimmunity has been validated. We evaluated the Food and Drug Administration-approved CD25-blocking monoclonal antibody daclizumab with regard to human T(reg) survival and function. In vitro, daclizumab did not mediate antibody-dependent or complement-mediated cytotoxicity but rather resulted in the down-regulation of FoxP3 selectively among CD25(high) CD45RA(neg) T(regs). Moreover, daclizumab-treated CD45RA(neg) T(regs) lost suppressive function and regained the ability to produce interferon-γ, consistent with reprogramming. To understand the impact of daclizumab on T(regs) in vivo, we performed a clinical trial of daclizumab in combination with an experimental cancer vaccine in patients with metastatic breast cancer. Daclizumab administration led to a marked and prolonged decrease in T(regs) in patients. Robust CD8 and CD4 T cell priming and boosting to all vaccine antigens were observed in the absence of autoimmunity. We conclude that CD25 blockade depletes and selectively reprograms T(regs) in concert with active immune therapy in cancer patients. These results suggest a mechanism to target cancer-associated T(regs) while avoiding autoimmunity.

Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.
Gaynor J Bates, Stephen B Fox, +4 authors, Alison H Banham.
J Clin Oncol, 2006 Dec 01; 24(34). PMID: 17135638
Highly Cited.
Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients.
Joannes F M Jacobs, Cornelis J A Punt, +8 authors, Gosse J Adema.
Clin Cancer Res, 2010 Aug 26; 16(20). PMID: 20736326
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.
R P Sutmuller, L M van Duivenvoorde, +6 authors, C J Melief.
J Exp Med, 2001 Sep 19; 194(6). PMID: 11560997    Free PMC article.
Highly Cited.
Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients.
M H Andersen, L O Pedersen, J C Becker, P T Straten.
Cancer Res, 2001 Feb 28; 61(3). PMID: 11221872
Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.
Aaron P Rapoport, Edward A Stadtmauer, +29 authors, Carl H June.
Nat Med, 2005 Oct 18; 11(11). PMID: 16227990
Highly Cited.
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.
David-Alexandre Gross, Stéphanie Graff-Dubois, +12 authors, Kostas Kosmatopoulos.
J Clin Invest, 2004 Feb 03; 113(3). PMID: 14755339    Free PMC article.
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
Afonso R M Almeida, Nicolas Legrand, Martine Papiernik, António A Freitas.
J Immunol, 2002 Oct 23; 169(9). PMID: 12391195
Highly Cited.
Dynamics of the immune reaction to pancreatic cancer from inception to invasion.
Carolyn E Clark, Sunil R Hingorani, +3 authors, Robert H Vonderheide.
Cancer Res, 2007 Oct 03; 67(19). PMID: 17909062
Highly Cited.
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
Makoto Miyara, Yumiko Yoshioka, +15 authors, Shimon Sakaguchi.
Immunity, 2009 May 26; 30(6). PMID: 19464196
Highly Cited.
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.
Guillaume Oldenhove, Nicolas Bouladoux, +11 authors, Yasmine Belkaid.
Immunity, 2009 Nov 10; 31(5). PMID: 19896394    Free PMC article.
Highly Cited.
Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease.
O Taguchi, T Takahashi.
Eur J Immunol, 1996 Jul 01; 26(7). PMID: 8766568
Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration.
Erica L Carpenter, Barbara A Vance, +3 authors, Robert H Vonderheide.
J Neuroimmunol, 2007 Dec 07; 193(1-2). PMID: 18053582
Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes.
E McLaughlin-Taylor, H Pande, +5 authors, S R Riddell.
J Med Virol, 1994 May 01; 43(1). PMID: 8083644
Highly Cited.
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
Petra Hoffmann, Ruediger Eder, +4 authors, Matthias Edinger.
Blood, 2006 Aug 19; 108(13). PMID: 16917003
Highly Cited.
Mechanisms of antibody immunotherapy on clonal islet reactive T cells.
P van de Linde, O M H Tysma, +4 authors, B O Roep.
Hum Immunol, 2006 May 25; 67(4-5). PMID: 16720206
The biology of interleukin-2.
Thomas R Malek.
Annu Rev Immunol, 2007 Dec 08; 26. PMID: 18062768
Highly Cited. Review.
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity.
J Shimizu, S Yamazaki, S Sakaguchi.
J Immunol, 1999 Nov 24; 163(10). PMID: 10553041
Highly Cited.
Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta.
Bibiana Bielekova, Nancy Richert, +9 authors, Roland Martin.
Proc Natl Acad Sci U S A, 2004 May 27; 101(23). PMID: 15161974    Free PMC article.
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.
E Y Woo, C S Chu, +6 authors, C H June.
Cancer Res, 2001 Jun 19; 61(12). PMID: 11406550
Highly Cited.
Telomerase-specific T-cell immunity in breast cancer: effect of vaccination on tumor immunosurveillance.
Susan M Domchek, Adri Recio, +12 authors, Robert H Vonderheide.
Cancer Res, 2007 Nov 03; 67(21). PMID: 17974999
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.
Thomas R Malek, Aixin Yu, +2 authors, Lin Kong.
Immunity, 2002 Aug 28; 17(2). PMID: 12196288
Highly Cited.
A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy.
Simone C Wuest, Jehad H Edwan, +7 authors, Bibiana Bielekova.
Nat Med, 2011 May 03; 17(5). PMID: 21532597    Free PMC article.
Highly Cited.
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.
D M Willerford, J Chen, +3 authors, F W Alt.
Immunity, 1995 Oct 01; 3(4). PMID: 7584142
Highly Cited.
Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells.
Andrew J Rech, Robert H Vonderheide.
Ann N Y Acad Sci, 2009 Sep 23; 1174. PMID: 19769742
Highly Cited. Review.
CD28 costimulation is essential for human T regulatory expansion and function.
Tatiana N Golovina, Tatiana Mikheeva, +12 authors, James L Riley.
J Immunol, 2008 Aug 08; 181(4). PMID: 18684977    Free PMC article.
Anti-CD25 antibodies affect cytokine synthesis pattern of human dendritic cells and decrease their ability to prime allogeneic CD4+ T cells.
K Mnasria, C Lagaraine, +3 authors, C Baron.
J Leukoc Biol, 2008 May 10; 84(2). PMID: 18467656
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.
Ruka Setoguchi, Shohei Hori, Takeshi Takahashi, Shimon Sakaguchi.
J Exp Med, 2005 Mar 09; 201(5). PMID: 15753206    Free PMC article.
Highly Cited.
Regulatory T cells and immune tolerance.
Shimon Sakaguchi, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono.
Cell, 2008 May 31; 133(5). PMID: 18510923
Highly Cited. Review.
Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta.
Daniel Wynn, Michael Kaufman, +10 authors, CHOICE investigators.
Lancet Neurol, 2010 Feb 19; 9(4). PMID: 20163990
Highly Cited.
Development and application of a multiplexable flow cytometry-based assay to quantify cell-mediated cytolysis.
Lan-Feng Cao, Ludmila Krymskaya, +4 authors, Michael Kalos.
Cytometry A, 2010 Mar 17; 77(6). PMID: 20229499
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.
W J Leonard, J M Depper, +3 authors, W C Greene.
Nature, 1982 Nov 18; 300(5889). PMID: 6815536
Highly Cited.
Plasticity of CD4(+) FoxP3(+) T cells.
Xuyu Zhou, Samantha Bailey-Bucktrout, Lukas T Jeker, Jeffrey A Bluestone.
Curr Opin Immunol, 2009 Jun 09; 21(3). PMID: 19500966    Free PMC article.
Highly Cited. Review.
Stability of the regulatory T cell lineage in vivo.
Yuri P Rubtsov, Rachel E Niec, +5 authors, Alexander Y Rudensky.
Science, 2010 Oct 12; 329(5999). PMID: 20929851    Free PMC article.
Highly Cited.
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
S Onizuka, I Tawara, +3 authors, E Nakayama.
Cancer Res, 1999 Jul 09; 59(13). PMID: 10397255
Highly Cited.
Homeostasis of peripheral FoxP3(+) CD4 (+) regulatory T cells in patients with early and late stage breast cancer.
Andrew J Rech, Rosemarie Mick, +3 authors, Robert H Vonderheide.
Cancer Immunol Immunother, 2009 Oct 27; 59(4). PMID: 19855964
Mechanisms of foxp3+ T regulatory cell-mediated suppression.
Ethan M Shevach.
Immunity, 2009 May 26; 30(5). PMID: 19464986
Highly Cited. Review.
Regulatory T cells: overcoming suppression of T-cell immunity.
Tatiana N Golovina, Robert H Vonderheide.
Cancer J, 2010 Aug 10; 16(4). PMID: 20693845
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.
Allison L Bayer, Aixin Yu, Dennis Adeegbe, Thomas R Malek.
J Exp Med, 2005 Mar 09; 201(5). PMID: 15753210    Free PMC article.
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes.
R H Vonderheide, W C Hahn, J L Schultze, L M Nadler.
Immunity, 1999 Jul 14; 10(6). PMID: 10403642
Highly Cited.
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
S Sakaguchi, N Sakaguchi, +2 authors, M Toda.
J Immunol, 1995 Aug 01; 155(3). PMID: 7636184
Highly Cited.
A function for interleukin 2 in Foxp3-expressing regulatory T cells.
Jason D Fontenot, Jeffrey P Rasmussen, Marc A Gavin, Alexander Y Rudensky.
Nat Immunol, 2005 Oct 18; 6(11). PMID: 16227984
Highly Cited.
Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.
Bibiana Bielekova, Marta Catalfamo, +6 authors, Roland Martin.
Proc Natl Acad Sci U S A, 2006 Apr 06; 103(15). PMID: 16585503    Free PMC article.
Highly Cited.
Window of opportunity for daclizumab.
Kimberly S Schluns.
Nat Med, 2011 May 07; 17(5). PMID: 21546970
Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.
Tatiana N Golovina, Tatiana Mikheeva, +3 authors, James L Riley.
PLoS One, 2011 Jan 22; 6(1). PMID: 21253593    Free PMC article.
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
Duane A Mitchell, Xiuyu Cui, +13 authors, John H Sampson.
Blood, 2011 Jul 20; 118(11). PMID: 21768296    Free PMC article.
Application of IL-2 therapy to target T regulatory cell function.
Ethan M Shevach.
Trends Immunol, 2012 Sep 07; 33(12). PMID: 22951308    Free PMC article.
Comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model.
Antonio Miguel, María José Herrero, +4 authors, Salvador F Aliño.
Toxins (Basel), 2012 Dec 04; 4(11). PMID: 23202306    Free PMC article.
L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
Michael Degregorio, Michael Degregorio, +4 authors, Michael Wolf.
Oncoimmunology, 2012 Dec 18; 1(8). PMID: 23243615    Free PMC article.
Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response.
Michel DuPage, Tyler Jacks.
Curr Opin Immunol, 2013 Mar 08; 25(2). PMID: 23465466    Free PMC article.
Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.
Stephen R Goding, Kyle A Wilson, +7 authors, Paul Andrew Antony.
J Immunol, 2013 Mar 29; 190(9). PMID: 23536636    Free PMC article.
Highly Cited.
Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis.
Heinz Wiendl, Catharina C Gross.
Nat Rev Neurol, 2013 Jun 05; 9(7). PMID: 23732529
Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer.
Vincent Lavoué, Aurélie Thédrez, +6 authors, Florian Cabillic.
J Transl Med, 2013 Jun 15; 11. PMID: 23763830    Free PMC article.
The immune system and inflammation in breast cancer.
Xinguo Jiang, David J Shapiro.
Mol Cell Endocrinol, 2013 Jun 25; 382(1). PMID: 23791814    Free PMC article.
STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells.
Carl Weidinger, Patrick J Shaw, Stefan Feske.
EMBO Mol Med, 2013 Aug 08; 5(9). PMID: 23922331    Free PMC article.
Innate and adaptive immune cells in the tumor microenvironment.
Thomas F Gajewski, Hans Schreiber, Yang-Xin Fu.
Nat Immunol, 2013 Sep 21; 14(10). PMID: 24048123    Free PMC article.
Highly Cited. Review.
High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
Amit A Lugade, Suresh Kalathil, +2 authors, Yasmin Thanavala.
Oncoimmunology, 2013 Sep 28; 2(7). PMID: 24073364    Free PMC article.
Impact of T cell selection methods in the success of clinical adoptive immunotherapy.
Natalia Ramírez, Lorea Beloki, +5 authors, Eduardo Olavarría.
Cell Mol Life Sci, 2013 Oct 01; 71(7). PMID: 24077876
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.
Daisuke Sugiyama, Hiroyoshi Nishikawa, +10 authors, Shimon Sakaguchi.
Proc Natl Acad Sci U S A, 2013 Oct 16; 110(44). PMID: 24127572    Free PMC article.
Highly Cited.
How numbers, nature, and immune status of foxp3(+) regulatory T-cells shape the early immunological events in tumor development.
Guillaume Darrasse-Jèze, Katrina Podsypanina.
Front Immunol, 2013 Oct 18; 4. PMID: 24133490    Free PMC article.
Microenvironmental regulation of tumor progression and metastasis.
Daniela F Quail, Johanna A Joyce.
Nat Med, 2013 Nov 10; 19(11). PMID: 24202395    Free PMC article.
Highly Cited. Review.
Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma.
Long Chen, Shuang Zhou, +9 authors, Chunmin Liang.
Mol Cancer, 2013 Dec 07; 12(1). PMID: 24304581    Free PMC article.
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets.
Kate S Smigiel, Elizabeth Richards, +4 authors, Daniel J Campbell.
J Exp Med, 2014 Jan 01; 211(1). PMID: 24378538    Free PMC article.
Highly Cited.
Harnessing the immune system for the treatment of breast cancer.
Xinguo Jiang.
J Zhejiang Univ Sci B, 2014 Jan 07; 15(1). PMID: 24390741    Free PMC article.
Role of crosslinking for agonistic CD40 monoclonal antibodies as immune therapy of cancer.
Lee P Richman, Robert H Vonderheide.
Cancer Immunol Res, 2014 Jan 15; 2(1). PMID: 24416732    Free PMC article.
Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an "innocent bystander".
Lucia Gelao, Carmen Criscitiello, +2 authors, Giuseppe Curigliano.
Toxins (Basel), 2014 Mar 07; 6(3). PMID: 24594636    Free PMC article.
Treg functional stability and its responsiveness to the microenvironment.
Joseph Barbi, Drew Pardoll, Fan Pan.
Immunol Rev, 2014 Apr 10; 259(1). PMID: 24712463    Free PMC article.
Rational combinations of immunotherapeutics that target discrete pathways.
Stefani Spranger, Thomas Gajewski.
J Immunother Cancer, 2013 Jan 01; 1. PMID: 24829752    Free PMC article.
Stromal reengineering to treat pancreas cancer.
Ingunn M Stromnes, Kathleen E DelGiorno, Philip D Greenberg, Sunil R Hingorani.
Carcinogenesis, 2014 Jun 09; 35(7). PMID: 24908682    Free PMC article.
Induced regulatory T cells in inhibitory microenvironments created by cancer.
Theresa L Whiteside.
Expert Opin Biol Ther, 2014 Jun 18; 14(10). PMID: 24934899    Free PMC article.
Immunotherapy in pediatric malignancies: current status and future perspectives.
Christian M Capitini, Mario Otto, Kenneth B DeSantes, Paul M Sondel.
Future Oncol, 2014 Aug 26; 10(9). PMID: 25145434    Free PMC article.
Targeting regulatory T cells to improve vaccine immunogenicity in early life.
Jorjoh Ndure, Katie L Flanagan.
Front Microbiol, 2014 Oct 14; 5. PMID: 25309517    Free PMC article.
Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.
Jason S Ellis, Helen Braley-Mullen.
Immunology, 2014 Oct 17; 144(4). PMID: 25318356    Free PMC article.
Clinical Impact of Regulatory T cells (Treg) in Cancer and HIV.
Theresa L Whiteside.
Cancer Microenviron, 2014 Nov 12; 8(3). PMID: 25385463    Free PMC article.
Immunotherapy for the treatment of breast cancer.
Brenda Ernst, Karen S Anderson.
Curr Oncol Rep, 2015 Feb 14; 17(2). PMID: 25677118
The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome.
Romy E Hoeppli, Dan Wu, Laura Cook, Megan K Levings.
Front Immunol, 2015 Mar 06; 6. PMID: 25741338    Free PMC article.
Targeting the innate immune system as immunotherapy for acute myeloid leukemia.
Emily Curran, Leticia Corrales, Justin Kline.
Front Oncol, 2015 Apr 29; 5. PMID: 25914882    Free PMC article.
The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies.
Haoqing Shi, Xiangjie Qi, +4 authors, Haitao Niu.
Chin J Cancer Res, 2015 May 06; 27(2). PMID: 25937774    Free PMC article.
Development of individualized anti-metastasis strategies by engineering nanomedicines.
Qianjun He, Shengrong Guo, Zhiyong Qian, Xiaoyuan Chen.
Chem Soc Rev, 2015 Jun 10; 44(17). PMID: 26056688    Free PMC article.
A top-down view of the tumor microenvironment: structure, cells and signaling.
Rahul Bhome, Marc D Bullock, +4 authors, Alex H Mirnezami.
Front Cell Dev Biol, 2015 Jun 16; 3. PMID: 26075202    Free PMC article.
Ubiquitin-dependent regulation of Foxp3 and Treg function.
Joseph Barbi, Drew M Pardoll, Fan Pan.
Immunol Rev, 2015 Jun 19; 266(1). PMID: 26085205    Free PMC article.
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression.
Alfred P See, Jonathon J Parker, Allen Waziri.
J Neurooncol, 2015 Jul 01; 123(3). PMID: 26123363
Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency.
Megan A O'Connor, Jennifer L Vella, William R Green.
J Gen Virol, 2015 Aug 09; 97(2). PMID: 26253145    Free PMC article.
Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.
Claudia Voena, Matteo Menotti, +19 authors, Roberto Chiarle.
Cancer Immunol Res, 2015 Oct 01; 3(12). PMID: 26419961    Free PMC article.
Regulatory T Cells Modulate DNA Vaccine Immunogenicity at Early Time via Functional CD4(+) T Cells and Antigen Duration.
Lizeng Qin, Guosheng Jiang, Jinxiang Han, Norman L Letvin.
Front Immunol, 2015 Oct 21; 6. PMID: 26483796    Free PMC article.
Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy.
Kelly Kersten, Camilla Salvagno, Karin E de Visser.
Front Immunol, 2015 Oct 27; 6. PMID: 26500653    Free PMC article.
Immunosuppressive cells in tumor immune escape and metastasis.
Yang Liu, Xuetao Cao.
J Mol Med (Berl), 2015 Dec 23; 94(5). PMID: 26689709
Transforming Cancer Prevention through Precision Medicine and Immune-oncology.
Thomas W Kensler, Avrum Spira, +9 authors, Scott M Lippman.
Cancer Prev Res (Phila), 2016 Jan 09; 9(1). PMID: 26744449    Free PMC article.
Highly Cited.
SHARPINing the knowledge of TCR signal control.
Melissa Bowman, Fan Pan, Edward W Harhaj.
Nat Immunol, 2016 Feb 18; 17(3). PMID: 26882251
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Sjoerd H van der Burg, Ramon Arens, +2 authors, Cornelis J M Melief.
Nat Rev Cancer, 2016 Mar 12; 16(4). PMID: 26965076
Highly Cited. Review.
Anti-CD25 monoclonal antibody Fc variants differentially impact regulatory T cells and immune homeostasis.
David J Huss, Alex F Pellerin, +5 authors, Jason D Fontenot.
Immunology, 2016 Mar 26; 148(3). PMID: 27012310    Free PMC article.
Peripheral Blood Regulatory T-Cell and Type 1 Helper T-Cell Population Decrease after Hepatic Artery Embolization.
Haruyuki Takaki, Naoko Imai, +6 authors, Joseph P Erinjeri.
J Vasc Interv Radiol, 2016 Apr 17; 27(10). PMID: 27084711    Free PMC article.
Emerging Opportunities and Challenges in Cancer Immunotherapy.
Theresa L Whiteside, Sandra Demaria, +2 authors, Ignacio Melero.
Clin Cancer Res, 2016 Apr 17; 22(8). PMID: 27084738    Free PMC article.
Highly Cited. Review.
Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers.
Takuro Saito, Hiroyoshi Nishikawa, +19 authors, Shimon Sakaguchi.
Nat Med, 2016 Apr 26; 22(6). PMID: 27111280
Highly Cited.
Roles of regulatory T cells in cancer immunity.
Yoshiko Takeuchi, Hiroyoshi Nishikawa.
Int Immunol, 2016 May 11; 28(8). PMID: 27160722    Free PMC article.
Highly Cited. Review.
Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma.
Wei Sun, Wei-Jin Li, +5 authors, Wei-Ping Wen.
Oncotarget, 2016 Oct 23; 7(25). PMID: 27177223    Free PMC article.
Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Ruth J Davis, Carter Van Waes, Clint T Allen.
Oral Oncol, 2016 May 25; 58. PMID: 27215705    Free PMC article.
Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside.
R Bhome, H A Al Saihati, +5 authors, A H Mirnezami.
New Horiz Transl Med, 2016 Jun 09; 3(1). PMID: 27275004    Free PMC article.
Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and clinical results of a randomized phase II trial.
Jason J Luke, Yuanyuan Zha, Karen Matijevich, Thomas F Gajewski.
J Immunother Cancer, 2016 Jun 23; 4. PMID: 27330808    Free PMC article.
Pancreatic cancer biology and genetics from an evolutionary perspective.
Alvin Makohon-Moore, Christine A Iacobuzio-Donahue.
Nat Rev Cancer, 2016 Jul 23; 16(9). PMID: 27444064    Free PMC article.
Highly Cited. Review.
Harnessing immunosurveillance: current developments and future directions in cancer immunotherapy.
Maureen L Drakes, Patrick J Stiff.
Immunotargets Ther, 2014 Jan 01; 3. PMID: 27471706    Free PMC article.
The role of regulatory T cells in cancer immunology.
Theresa L Whiteside.
Immunotargets Ther, 2015 Jan 01; 4. PMID: 27471721    Free PMC article.
Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting.
Belal Chaudhary, Eyad Elkord.
Vaccines (Basel), 2016 Aug 12; 4(3). PMID: 27509527    Free PMC article.
Highly Cited. Review.
Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells.
Jon Amund Kyte, Steinar Aamdal, +6 authors, Gunnar Kvalheim.
Oncoimmunology, 2016 Dec 22; 5(11). PMID: 27999747    Free PMC article.
Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases.
Jason S Ellis, Helen Braley-Mullen.
J Clin Med, 2017 Jan 31; 6(2). PMID: 28134752    Free PMC article.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.
Frederick Arce Vargas, Andrew J S Furness, +29 authors, Sergio A Quezada.
Immunity, 2017 Apr 16; 46(4). PMID: 28410988    Free PMC article.
Highly Cited.
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells.
Rodrigo Vazquez-Lombardi, Claudia Loetsch, +8 authors, Daniel Christ.
Nat Commun, 2017 May 13; 8. PMID: 28497796    Free PMC article.
B cells inhibit the antitumor immunity against an established murine fibrosarcoma.
Andrea Maglioco, Damián G Machuca, +7 authors, Graciela I Dran.
Oncol Lett, 2017 May 20; 13(5). PMID: 28521429    Free PMC article.
Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses.
Dong Sun Oh, Heegon Kim, +4 authors, Heung Kyu Lee.
Oncotarget, 2017 May 26; 8(29). PMID: 28537894    Free PMC article.
Immunotherapy for Breast Cancer: What Are We Missing?
Robert H Vonderheide, Susan M Domchek, Amy S Clark.
Clin Cancer Res, 2017 Jun 03; 23(11). PMID: 28572258    Free PMC article.
Highly Cited.
Molecular Pathways: Targeting the Microenvironment of Liver Metastases.
Simon Milette, Jason K Sicklick, Andrew M Lowy, Pnina Brodt.
Clin Cancer Res, 2017 Jun 16; 23(21). PMID: 28615370    Free PMC article.
The regulation of immune tolerance by FOXP3.
Ling Lu, Joseph Barbi, Fan Pan.
Nat Rev Immunol, 2017 Aug 02; 17(11). PMID: 28757603    Free PMC article.
Highly Cited. Review.
Negative Correlation between Circulating CD4+FOXP3+CD127- Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria-Tetanus-Pertussis Vaccine Implies a Regulatory Role.
Jorjoh Ndure, Fatou Noho-Konteh, +10 authors, Katie L Flanagan.
Front Immunol, 2017 Sep 01; 8. PMID: 28855899    Free PMC article.
CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer.
Fee Bengsch, Dawson M Knoblock, +2 authors, Gregory L Beatty.
Cancer Immunol Immunother, 2017 Sep 01; 66(12). PMID: 28856392    Free PMC article.
Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer.
Dhifaf Sarhan, Caroline Leijonhufvud, +10 authors, Andreas Lundqvist.
Oncoimmunology, 2017 Sep 19; 6(8). PMID: 28920001    Free PMC article.
Nanomaterials for cancer immunotherapy.
Wantong Song, Sara N Musetti, Leaf Huang.
Biomaterials, 2017 Sep 30; 148. PMID: 28961532    Free PMC article.
Sox2 Communicates with Tregs Through CCL1 to Promote the Stemness Property of Breast Cancer Cells.
Yingxi Xu, Xiaoli Dong, +10 authors, Na Li.
Stem Cells, 2017 Oct 19; 35(12). PMID: 29044882    Free PMC article.
Posttraumatic Stress Disorder: An Immunological Disorder?
Zhewu Wang, Blaine Caughron, M Rita I Young.
Front Psychiatry, 2017 Nov 23; 8. PMID: 29163241    Free PMC article.
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity.
Christophe Pedros, Ann J Canonigo-Balancio, Kok-Fai Kong, Amnon Altman.
JCI Insight, 2017 Dec 08; 2(23). PMID: 29212947    Free PMC article.
Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers.
Geou-Yarh Liou.
J Immunol Res, 2018 Jan 31; 2017. PMID: 29379802    Free PMC article.
Regulatory T cells (Tregs): A major immune checkpoint to consider in combinatorial therapeutic HIV-1 vaccines.
Audrey Hubert, Nabila Seddiki.
Hum Vaccin Immunother, 2018 Jan 31; 14(6). PMID: 29381418    Free PMC article.
Harnessing the immune system in the battle against breast cancer.
Elizabeth S Nakasone, Sara A Hurvitz, Kelly E McCann.
Drugs Context, 2018 Feb 20; 7. PMID: 29456568    Free PMC article.
Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells.
Gap Ryol Lee.
Mediators Inflamm, 2018 Feb 22; 2017. PMID: 29463952    Free PMC article.
Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis.
Susanta Pahari, Gurpreet Kaur, +7 authors, Javed N Agrewala.
Front Immunol, 2018 Feb 27; 9. PMID: 29479353    Free PMC article.
CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges.
Stephen J Bagley, Arati S Desai, +2 authors, Donald M O'Rourke.
Neuro Oncol, 2018 Mar 07; 20(11). PMID: 29509936    Free PMC article.
Highly Cited. Review.
Immunotherapy for Breast Cancer: Current and Future Strategies.
Austin D Williams, Kyle K Payne, +4 authors, Julia Tchou.
Curr Surg Rep, 2018 Apr 17; 5. PMID: 29657904    Free PMC article.
Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.
David Wang, Jason Quiros, +12 authors, Michel DuPage.
Cell Rep, 2018 Jun 14; 23(11). PMID: 29898397    Free PMC article.
Highly Cited.
Spotlight on daclizumab: its potential in the treatment of multiple sclerosis.
Ron Milo, Olaf Stüve.
Degener Neurol Neuromuscul Dis, 2016 Nov 17; 6. PMID: 30050372    Free PMC article.
Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.
David H Munn, Madhav D Sharma, Theodore S Johnson.
Cancer Res, 2018 Sep 06; 78(18). PMID: 30181177    Free PMC article.
Regulatory T cells in the treatment of disease.
Amir Sharabi, Maria G Tsokos, +3 authors, George C Tsokos.
Nat Rev Drug Discov, 2018 Oct 13; 17(11). PMID: 30310234
Highly Cited. Review.
CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer.
Ning Pu, Guochao Zhao, +8 authors, Wenchuan Wu.
J Transl Med, 2018 Oct 26; 16(1). PMID: 30359281    Free PMC article.
Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.
Martin Y Fan, Jun Siong Low, +5 authors, Laurence A Turka.
Cell Rep, 2018 Nov 01; 25(5). PMID: 30380412    Free PMC article.
Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.
Chloé Laplagne, Marcin Domagala, +7 authors, Mary Poupot.
Int J Mol Sci, 2019 Sep 25; 20(19). PMID: 31547627    Free PMC article.
The influence of microenvironment on tumor immunotherapy.
Jieying Zhang, Zhaopeng Shi, +2 authors, Jun Mi.
FEBS J, 2019 Aug 01; 286(21). PMID: 31365790    Free PMC article.
Immunohistochemical distribution of FOXP3+ regulatory T cells in colorectal cancer patients.
Zhi-An Ling, Li-Jie Zhang, +4 authors, Jing-Jing Zeng.
Int J Clin Exp Pathol, 2018 Apr 01; 11(4). PMID: 31938291    Free PMC article.
Cancer Immunotherapies Targeting Tumor-Associated Regulatory T Cells.
Xiaoxu Ge, Yamei Zhao, +2 authors, Lifeng Sun.
Onco Targets Ther, 2020 Jan 31; 12. PMID: 31997881    Free PMC article.
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.
Haiping Wang, Fabien Franco, +17 authors, Ping-Chih Ho.
Nat Immunol, 2020 Feb 19; 21(3). PMID: 32066953    Free PMC article.
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations.
Curtis H Kugel, Stephen M Douglass, +40 authors, Ashani T Weeraratna.
Clin Cancer Res, 2018 Jun 15; 24(21). PMID: 29898988    Free PMC article.
Highly Cited.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity.
Masanori Onda, Kazuto Kobayashi, Ira Pastan.
Proc Natl Acad Sci U S A, 2019 Feb 15; 116(10). PMID: 30760587    Free PMC article.
Treg programming and therapeutic reprogramming in cancer.
Mariela A Moreno Ayala, Zehui Li, Michel DuPage.
Immunology, 2019 Mar 14; 157(3). PMID: 30866047    Free PMC article.
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory.
Wenhao Luo, Gang Yang, +8 authors, Taiping Zhang.
Cancer Cell Int, 2020 Mar 12; 20. PMID: 32158356    Free PMC article.
Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy.
Jung-Ho Kim, Beom Seok Kim, Sang-Kyou Lee.
Immune Netw, 2020 Mar 12; 20(1). PMID: 32158592    Free PMC article.
Blocking inflammation to improve immunotherapy of advanced cancer.
Antonio Macciò, Clelia Madeddu.
Immunology, 2019 Dec 11; 159(4). PMID: 31821533    Free PMC article.
Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy.
Hongwei Chen, Xin Luan, +7 authors, Duxin Sun.
Nanomedicine (Lond), 2019 Dec 24; 15(1). PMID: 31868112    Free PMC article.
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Yoshihiro Ohue, Hiroyoshi Nishikawa.
Cancer Sci, 2019 May 19; 110(7). PMID: 31102428    Free PMC article.
Highly Cited. Review.
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma.
S K Daniel, K M Sullivan, K P Labadie, V G Pillarisetty.
Clin Transl Med, 2019 Apr 02; 8(1). PMID: 30931508    Free PMC article.
Highly Cited. Review.
Immune Evasion by Head and Neck Cancer: Foundations for Combination Therapy.
Joshua D Horton, Hannah M Knochelmann, +2 authors, David M Neskey.
Trends Cancer, 2019 Apr 10; 5(4). PMID: 30961829    Free PMC article.
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies.
Rodolfo Daniel Cervantes-Villagrana, Damaris Albores-García, Alberto Rafael Cervantes-Villagrana, Sara Judit García-Acevez.
Signal Transduct Target Ther, 2020 Jun 20; 5(1). PMID: 32555170    Free PMC article.
Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment.
Tsubasa Miyazaki, Eiichi Ishikawa, Narushi Sugii, Masahide Matsuda.
Cancers (Basel), 2020 Jul 28; 12(7). PMID: 32707672    Free PMC article.
Daclizumab: Mechanisms of Action, Therapeutic Efficacy, Adverse Events and Its Uncovering the Potential Role of Innate Immune System Recruitment as a Treatment Strategy for Relapsing Multiple Sclerosis.
Stanley L Cohan, Elisabeth B Lucassen, Meghan C Romba, Stefanie N Linch.
Biomedicines, 2019 Mar 14; 7(1). PMID: 30862055    Free PMC article.
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody.
Tao Dao, Sung Soo Mun, +11 authors, David A Scheinberg.
Oncoimmunology, 2019 May 31; 8(7). PMID: 31143508    Free PMC article.
Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf.
Massimo Claudio Fantini, Agnese Favale, Sara Onali, Federica Facciotti.
Int J Mol Sci, 2020 Sep 18; 21(18). PMID: 32937953    Free PMC article.
The Role of the Tumor Microenvironment in Developing Successful Therapeutic and Secondary Prophylactic Breast Cancer Vaccines.
Benjamin Gordon, Vijayakrishna K Gadi.
Vaccines (Basel), 2020 Sep 18; 8(3). PMID: 32937885    Free PMC article.
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions.
Guoming Zeng, Libo Jin, +9 authors, Da Sun.
Cancer Manag Res, 2020 Oct 30; 12. PMID: 33116895    Free PMC article.
Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.
Meenal Datta, Lisa M Coussens, +2 authors, Rakesh K Jain.
Am Soc Clin Oncol Educ Book, 2019 May 18; 39. PMID: 31099649    Free PMC article.
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1.
Emarene Kalaw, Malcolm Lim, +21 authors, Amy E McCart Reed.
Br J Cancer, 2020 Sep 18; 123(11). PMID: 32939056    Free PMC article.
Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment.
Giuseppina Roscigno, Iolanda Scognamiglio, +4 authors, Gerolama Condorelli.
Cancers (Basel), 2020 Dec 17; 12(12). PMID: 33322132    Free PMC article.
Emerging immunotherapies for metastasis.
Sarah C Edwards, Wilma H M Hoevenaar, Seth B Coffelt.
Br J Cancer, 2020 Dec 03; 124(1). PMID: 33262520    Free PMC article.
Regulation of Treg Functions by the Ubiquitin Pathway.
Elena Montauti, Deyu Fang.
Adv Exp Med Biol, 2021 Feb 02; 1278. PMID: 33523442
Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy.
Helena Van Damme, Bruno Dombrecht, +26 authors, Jo Agnes Van Ginderachter.
J Immunother Cancer, 2021 Feb 17; 9(2). PMID: 33589525    Free PMC article.
Investigating T Cell Immunity in Cancer: Achievements and Prospects.
Zhen Zeng, Hui Yi Chew, +2 authors, James W Wells.
Int J Mol Sci, 2021 Apr 04; 22(6). PMID: 33809369    Free PMC article.
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer.
Yingjie Nie, Jiang He, +5 authors, Xin Chen.
Sci Signal, 2018 Jan 04; 11(511). PMID: 29295954    Free PMC article.
Hyperprogressive Disease: Main Features and Key Controversies.
Hugo Arasanz, Miren Zuazo, +15 authors, Ruth Vera.
Int J Mol Sci, 2021 May 01; 22(7). PMID: 33916696    Free PMC article.
Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies.
Yan Dong, Zhuo Wan, +2 authors, Li Liu.
Front Immunol, 2021 May 11; 12. PMID: 33968014    Free PMC article.
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Yi Zhao, Zhiyu Zhang, +11 authors, Wei Sun.
Front Oncol, 2021 May 25; 11. PMID: 34026621    Free PMC article.
A Novel CAR Expressing NK Cell Targeting CD25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers.
Moein Dehbashi, Zohreh Hojati, +5 authors, Mazdak Ganjalikhani-Hakemi.
Front Oncol, 2021 Jun 01; 11. PMID: 34055618    Free PMC article.
Therapeutic Targets and Tumor Microenvironment in Colorectal Cancer.
Gaetano Gallo, Giuseppina Vescio, Gilda De Paola, Giuseppe Sammarco.
J Clin Med, 2021 Jun 03; 10(11). PMID: 34070480    Free PMC article.
TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer.
María Paz Saldías, Diego Maureira, +6 authors, Oscar Cerda.
Front Oncol, 2021 Jun 29; 11. PMID: 34178620    Free PMC article.
Systematic Review.
Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors.
Robert H Vonderheide, Kimberly A Kraynyak, +14 authors, Jeffrey M Skolnik.
J Immunother Cancer, 2021 Jul 08; 9(7). PMID: 34230114    Free PMC article.
Immunopeptidomics-Guided Warehouse Design for Peptide-Based Immunotherapy in Chronic Lymphocytic Leukemia.
Annika Nelde, Yacine Maringer, +11 authors, Juliane S Walz.
Front Immunol, 2021 Jul 27; 12. PMID: 34305947    Free PMC article.
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study.
Dmitriy Zamarin, Omid Hamid, +6 authors, David S Hong.
Clin Cancer Res, 2020 Jun 27; 26(17). PMID: 32586937    Free PMC article.
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer.
Molly A Nelson, Worapol Ngamcherdtrakul, Shiuh-Wen Luoh, Wassana Yantasee.
Cancer Metastasis Rev, 2021 May 09; 40(2). PMID: 33963482    Free PMC article.
Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle.
Aikaterini Hatzioannou, Athina Boumpas, +4 authors, Panayotis Verginis.
Front Immunol, 2021 Sep 21; 12. PMID: 34539668    Free PMC article.
The Multifaceted Role of Regulatory T Cells in Breast Cancer.
Kevin Kos, Karin E de Visser.
Annu Rev Cancer Biol, 2021 Oct 12; 5. PMID: 34632244    Free PMC article.
The Breast Tumor Microenvironment: A Key Player in Metastatic Spread.
Lucas E L Terceiro, Chidalu A Edechi, +5 authors, Yvonne Myal.
Cancers (Basel), 2021 Oct 14; 13(19). PMID: 34638283    Free PMC article.
Cell-Based Regeneration and Treatment of Liver Diseases.
Julia Hofmann, Verena Hackl, +6 authors, Theresa Hautz.
Int J Mol Sci, 2021 Oct 14; 22(19). PMID: 34638617    Free PMC article.
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer.
Lei Wang, Diana L Simons, +9 authors, Peter P Lee.
Nat Immunol, 2019 Jul 10; 20(9). PMID: 31285626    Free PMC article.
Highly Cited.
Functional Diversities of Regulatory T Cells in the Context of Cancer Immunotherapy.
Ran Gao, Guo-Ping Shi, Jing Wang.
Front Immunol, 2022 Apr 05; 13. PMID: 35371055    Free PMC article.
Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives.
Jiaqi Liang, Guoshu Bi, +3 authors, Qun Wang.
J Immunol Res, 2022 May 03; 2022. PMID: 35497874    Free PMC article.