Journal Article
. 2012 Oct;15(3).
doi: 10.4048/jbc.2012.15.3.265.

Personalized medicine in breast cancer: a systematic review

Sang-Hoon Cho 1 Jongsu Jeon  Seung Il Kim  
Affiliations
  • PMID: 23091538
  •     63 References
  •     21 citations

Abstract

The recent advent of "-omics" technologies have heralded a new era of personalized medicine. Personalized medicine is referred to as the ability to segment heterogeneous subsets of patients whose response to a therapeutic intervention within each subset is homogeneous. This new paradigm in healthcare is beginning to affect both research and clinical practice. The key to success in personalized medicine is to uncover molecular biomarkers that drive individual variability in clinical outcomes or drug responses. In this review, we begin with an overview of personalized medicine in breast cancer and illustrate the most encountered statistical approaches in the recent literature tailored for uncovering gene signatures.

Keywords: Biomarker discovery; Breast neoplasms; Individualized medicine; Predictive biomarker; Prognostic biomarker.

Predicting the clinical status of human breast cancer by using gene expression profiles.
M West, C Blanchette, +7 authors, J R Nevins.
Proc Natl Acad Sci U S A, 2001 Sep 20; 98(20). PMID: 11562467    Free PMC article.
Highly Cited.
Chemosensitivity prediction by transcriptional profiling.
J E Staunton, D K Slonim, +10 authors, T R Golub.
Proc Natl Acad Sci U S A, 2001 Sep 13; 98(19). PMID: 11553813    Free PMC article.
Highly Cited.
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer.
Charles L Vogel, Melody A Cobleigh, +10 authors, Michael Press.
J Clin Oncol, 2002 Feb 01; 20(3). PMID: 11821453
Highly Cited.
Tumor classification by partial least squares using microarray gene expression data.
Danh V Nguyen, David M Rocke.
Bioinformatics, 2002 Feb 12; 18(1). PMID: 11836210
Highly Cited.
Between-group analysis of microarray data.
Aedín C Culhane, Guy Perrière, +2 authors, Desmond G Higgins.
Bioinformatics, 2002 Dec 20; 18(12). PMID: 12490444
Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays.
Nitin Jain, Jayant Thatte, +3 authors, Jae K Lee.
Bioinformatics, 2003 Oct 14; 19(15). PMID: 14555628
Highly Cited.
A generalized likelihood ratio test to identify differentially expressed genes from microarray data.
Song Wang, Stewart Ethier.
Bioinformatics, 2003 Dec 25; 20(1). PMID: 14693815
Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay.
Maureen Cronin, Mylan Pho, +5 authors, Joffre B Baker.
Am J Pathol, 2003 Dec 26; 164(1). PMID: 14695316    Free PMC article.
Highly Cited.
Detecting differential gene expression with a semiparametric hierarchical mixture method.
Michael A Newton, Amine Noueiry, Deepayan Sarkar, Paul Ahlquist.
Biostatistics, 2004 Apr 01; 5(2). PMID: 15054023
Highly Cited.
Developing optimal prediction models for cancer classification using gene expression data.
Mat Soukup, Jae K Lee.
J Bioinform Comput Biol, 2004 Aug 04; 1(4). PMID: 15290759
Hormone receptor status and survival in a population-based cohort of patients with breast carcinoma.
Victor R Grann, Andrea B Troxel, +3 authors, Alfred I Neugut.
Cancer, 2005 Apr 22; 103(11). PMID: 15844176
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
Lancet, 2005 May 17; 365(9472). PMID: 15894097
Highly Cited.
Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer.
John Hornberger, Leon E Cosler, Gary H Lyman.
Am J Manag Care, 2005 May 19; 11(5). PMID: 15898220
Robust classification modeling on microarray data using misclassification penalized posterior.
Mat Soukup, HyungJun Cho, Jae K Lee.
Bioinformatics, 2005 Jun 18; 21 Suppl 1. PMID: 15961487
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer.
Edward H Romond, Edith A Perez, +22 authors, Norman Wolmark.
N Engl J Med, 2005 Oct 21; 353(16). PMID: 16236738
Highly Cited.
Linear models and empirical bayes methods for assessing differential expression in microarray experiments.
Gordon K Smyth.
Stat Appl Genet Mol Biol, 2006 May 02; 3. PMID: 16646809
Highly Cited.
Genomics and personalized medicine.
Michelle Meadows.
FDA Consum, 2006 May 04; 39(6). PMID: 16669113
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.
Soonmyung Paik, Gong Tang, +11 authors, Norman Wolmark.
J Clin Oncol, 2006 May 25; 24(23). PMID: 16720680
Highly Cited.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Richard M Neve, Koei Chin, +24 authors, Joe W Gray.
Cancer Cell, 2006 Dec 13; 10(6). PMID: 17157791    Free PMC article.
Highly Cited.
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.
Ian Smith, Marion Procter, +22 authors, HERA study team.
Lancet, 2007 Jan 09; 369(9555). PMID: 17208639
Highly Cited.
Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib.
Gary M Clark, Denni M Zborowski, +4 authors, Frances A Shepherd.
J Thorac Oncol, 2007 Apr 06; 1(8). PMID: 17409968
Assessing differential gene expression with small sample sizes in oligonucleotide arrays using a mean-variance model.
Jianhua Hu, Fred A Wright.
Biometrics, 2007 Apr 24; 63(1). PMID: 17447928
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery.
Jae K Lee, Dmytro M Havaleshko, +5 authors, Dan Theodorescu.
Proc Natl Acad Sci U S A, 2007 Aug 02; 104(32). PMID: 17666531    Free PMC article.
Highly Cited.
Prognostic versus predictive value of biomarkers in oncology.
C N A M Oldenhuis, S F Oosting, J A Gietema, E G E de Vries.
Eur J Cancer, 2008 Apr 09; 44(7). PMID: 18396036
Review.
Multiple biomarker tissue microarrays: bioinformatics and practical approaches.
Søren M Bentzen, Francesca M Buffa, George D Wilson.
Cancer Metastasis Rev, 2008 Apr 26; 27(3). PMID: 18437294
Review.
Prognostic factors versus predictive factors: Examples from a clinical trial of erlotinib.
Gary M Clark.
Mol Oncol, 2009 Apr 23; 1(4). PMID: 19383314    Free PMC article.
Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.
John H Phan, Richard A Moffitt, +4 authors, May D Wang.
Trends Biotechnol, 2009 May 05; 27(6). PMID: 19409634    Free PMC article.
Review.
Biomarkers and surrogate end points--the challenge of statistical validation.
Marc Buyse, Daniel J Sargent, +2 authors, Aimery de Gramont.
Nat Rev Clin Oncol, 2010 Apr 07; 7(6). PMID: 20368727
Review.
Multi-gene expression-based statistical approaches to predicting patients' clinical outcomes and responses.
Feng Cheng, Sang-Hoon Cho, Jae K Lee.
Methods Mol Biol, 2010 Jul 24; 620. PMID: 20652516
Multigene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer.
Alykhan S Nagji, Sang-Hoon Cho, +2 authors, David R Jones.
Mol Cancer Ther, 2010 Aug 18; 9(10). PMID: 20713531    Free PMC article.
The curse of dimensionality: a blessing to personalized medicine.
Daniel R Catchpoole, Paul Kennedy, David B Skillicorn, Simeon Simoff.
J Clin Oncol, 2010 Nov 03; 28(34). PMID: 21041706
A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment.
Steven Christopher Smith, Alexander Spyridon Baras, +9 authors, Dan Theodorescu.
Lancet Oncol, 2011 Jan 25; 12(2). PMID: 21256081    Free PMC article.
Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up.
R L Ridolfi, P P Rosen, +2 authors, V Miké.
Cancer, 1977 Oct 01; 40(4). PMID: 907958
Highly Cited.
Factors predicting treatment responsiveness and prognosis in node-negative breast cancer. The International (Ludwig) Breast Cancer Study Group.
A M Neville, R Bettelheim, +7 authors, K N Price.
J Clin Oncol, 1992 May 01; 10(5). PMID: 1569442
Conservative surgery and radiation therapy in black women with early stage breast cancer. Patterns of failure and analysis of outcome.
L Pierce, B Fowble, +3 authors, R L Goodman.
Cancer, 1992 Jun 01; 69(11). PMID: 1571914
Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.
M C Paterson, K D Dietrich, +7 authors, W A McBlain.
Cancer Res, 1991 Jan 15; 51(2). PMID: 1670762
The long term prognostic significance of c-erbB-2 in primary breast cancer.
J Winstanley, T Cooke, +7 authors, P S Rudland.
Br J Cancer, 1991 Mar 01; 63(3). PMID: 1672256    Free PMC article.
HER-2/neu amplification predicts poor survival in node-positive breast cancer.
A Borg, A K Tandon, +5 authors, W L McGuire.
Cancer Res, 1990 Jul 15; 50(14). PMID: 1973070
Highly Cited.
NIH consensus conference. Treatment of early-stage breast cancer.
JAMA, 1991 Jan 16; 265(3). PMID: 1984541
Highly Cited. Review.
Follow-up study of HER-2/neu amplification in primary breast cancer.
G M Clark, W L McGuire.
Cancer Res, 1991 Feb 01; 51(3). PMID: 1988136
Review.
Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years.
P P Rosen, S Groshen, +2 authors, S Hellman.
J Clin Oncol, 1989 Sep 01; 7(9). PMID: 2549203
Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas.
V Le Doussal, M Tubiana-Hulin, +3 authors, M Brunet.
Cancer, 1989 Nov 01; 64(9). PMID: 2551477
Prognostic factors in breast cancer.
R A Saez, W L McGuire, G M Clark.
Semin Surg Oncol, 1989 Jan 01; 5(2). PMID: 2657970
Review.
Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases.
C L Carter, C Allen, D E Henson.
Cancer, 1989 Jan 01; 63(1). PMID: 2910416
Highly Cited.
Tubular carcinoma of the breast. A long term follow-up.
P H Carstens, R A Greenberg, D Francis, H Lyon.
Histopathology, 1985 Mar 01; 9(3). PMID: 2987100
Pure mucinous carcinomas of breast: morphologic features and prognostic correlates.
F Clayton.
Hum Pathol, 1986 Jan 01; 17(1). PMID: 3002950
Breast cancer prognosis in a mixed Caucasian-Hispanic population.
M B Daly, G M Clark, W L McGuire.
J Natl Cancer Inst, 1985 Apr 01; 74(4). PMID: 3857371
Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update.
B Fisher, M Bauer, +7 authors, R Margolese.
Cancer, 1983 Nov 01; 52(9). PMID: 6352003
Highly Cited.
Breast cancer in the medial half. Results of 1978 National Survey of the American College of Surgeons.
T Nemoto, N Natarajan, +2 authors, G P Murphy.
Cancer, 1983 Apr 15; 51(8). PMID: 6825053
Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States.
R M Elledge, G M Clark, G C Chamness, C K Osborne.
J Natl Cancer Inst, 1994 May 04; 86(9). PMID: 7908990
Highly Cited.
Breast cancer outcome and predictors of outcome: are there age differentials?
K S Albain, D C Allred, G M Clark.
J Natl Cancer Inst Monogr, 1994 Jan 01; (16). PMID: 7999467
Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer.
A J Nixon, D Neuberg, +7 authors, J R Harris.
J Clin Oncol, 1994 May 01; 12(5). PMID: 8164038
Highly Cited.
Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0/T2N0M0 patients with long-term follow-up.
P P Rosen, S Groshen, D W Kinne, L Norton.
J Clin Oncol, 1993 Nov 01; 11(11). PMID: 8229123
Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality.
D C Classen, S L Pestotnik, +2 authors, J P Burke.
JAMA, 1997 Jan 22; 277(4). PMID: 9002492
Highly Cited.
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
J P Struewing, P Hartge, +6 authors, M A Tucker.
N Engl J Med, 1997 May 15; 336(20). PMID: 9145676
Highly Cited.
Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies.
J Lazarou, B H Pomeranz, P N Corey.
JAMA, 1998 Apr 29; 279(15). PMID: 9555760
Highly Cited.
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
T R Golub, D K Slonim, +9 authors, E S Lander.
Science, 1999 Oct 16; 286(5439). PMID: 10521349
Highly Cited.
Knowledge-based analysis of microarray gene expression data by using support vector machines.
M P Brown, W N Grundy, +5 authors, D Haussler.
Proc Natl Acad Sci U S A, 2000 Jan 05; 97(1). PMID: 10618406    Free PMC article.
Highly Cited.
Support vector machine classification and validation of cancer tissue samples using microarray expression data.
T S Furey, N Cristianini, +3 authors, D Haussler.
Bioinformatics, 2000 Dec 20; 16(10). PMID: 11120680
Highly Cited.
Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.
Biomarkers Definitions Working Group..
Clin Pharmacol Ther, 2001 Mar 10; 69(3). PMID: 11240971
Highly Cited. Review.
Clinical application of pharmacogenetics.
B B Spear, M Heath-Chiozzi, J Huff.
Trends Mol Med, 2001 Apr 28; 7(5). PMID: 11325631
On differential variability of expression ratios: improving statistical inference about gene expression changes from microarray data.
M A Newton, C M Kendziorski, +2 authors, K W Tsui.
J Comput Biol, 2001 May 08; 8(1). PMID: 11339905
Highly Cited.
Assessing gene significance from cDNA microarray expression data via mixed models.
R D Wolfinger, G Gibson, +5 authors, R S Paules.
J Comput Biol, 2001 Dec 19; 8(6). PMID: 11747616
Highly Cited.
NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Justin Maykel, Jian Hua Liu, +3 authors, JeanMarie Houghton.
Dig Dis Sci, 2014 May 07; 59(6). PMID: 24798995    Free PMC article.
Personal genomes, quantitative dynamic omics and personalized medicine.
George I Mias, Michael Snyder.
Quant Biol, 2013 Mar 01; 1(1). PMID: 25798291    Free PMC article.
SEOM clinical guidelines in early-stage breast cancer 2015.
J A Garcia-Saenz, B Bermejo, +7 authors, E Ciruelos.
Clin Transl Oncol, 2015 Oct 27; 17(12). PMID: 26497356    Free PMC article.
Improving accuracy of diagnostic studies in a world with limited resources: a road ahead.
Giuseppe Lippi, Mario Plebani.
Ann Transl Med, 2016 Feb 24; 4(3). PMID: 26904565    Free PMC article.
Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine.
Sudheer Gupta, Kumardeep Chaudhary, +5 authors, Gajendra P S Raghava.
Sci Rep, 2016 Apr 01; 6. PMID: 27030518    Free PMC article.
Are We Ready for the Fourth Industrial Revolution?
H-A Park.
Yearb Med Inform, 2016 Nov 11; (1). PMID: 27830223    Free PMC article.
Quantitative proteomics of breast tumors: Tissue quality assessment to clinical biomarkers.
Yi Chen, David Britton, +4 authors, John M Koomen.
Proteomics, 2017 Jan 28; 17(6). PMID: 28127872    Free PMC article.
Personalized medicine in Europe: not yet personal enough?
Antonello Di Paolo, François Sarkozy, Bettina Ryll, Uwe Siebert.
BMC Health Serv Res, 2017 Apr 21; 17(1). PMID: 28424057    Free PMC article.
Review.
Saving costs in cancer patient management through molecular imaging.
Carl von Gall, Piotr Maniawski, +3 authors, Antonis Kalemis.
Eur J Nucl Med Mol Imaging, 2017 Aug 16; 44(13). PMID: 28808743    Free PMC article.
Intensive follow-up for women with breast cancer: review of clinical, economic and patient's preference domains through evidence to decision framework.
Alessandra Lafranconi, Liisa Pylkkänen, +9 authors, Maria José Martinez-Zapata.
Health Qual Life Outcomes, 2017 Oct 21; 15(1). PMID: 29052503    Free PMC article.
Systematic Review.
Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate.
Wensheng Zhang, Andrea Edwards, Erik K Flemington, Kun Zhang.
Sci Rep, 2017 Oct 24; 7(1). PMID: 29057889    Free PMC article.
Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts.
Jeffrey A Thompson, Brock C Christensen, Carmen J Marsit.
Sci Rep, 2018 Mar 28; 8(1). PMID: 29581450    Free PMC article.
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer.
Mousumi Majumder, Pinki Nandi, +2 authors, Peeyush K Lala.
Int J Mol Sci, 2018 Mar 30; 19(4). PMID: 29596308    Free PMC article.
Review.
The Ethnic-Specific Spectrum of Germline Nucleotide Variants in DNA Damage Response and Repair Genes in Hereditary Breast and Ovarian Cancer Patients of Tatar Descent.
Olga I Brovkina, Leila Shigapova, +7 authors, Oleg A Gusev.
Front Oncol, 2018 Oct 20; 8. PMID: 30333958    Free PMC article.
Artificial Intelligence in Obstetrics and Gynaecology: Is This the Way Forward?
Elif Iliria Emin, Ece Emin, +3 authors, Michail Sideris.
In Vivo, 2019 Sep 01; 33(5). PMID: 31471403    Free PMC article.
Review.
Clinical Validation of BCT Scores With Prognostic Factors in Hormone Receptor-positive, HER2-negative Early Breast Cancer.
Jeeyeon Lee, Won Hwa Kim, +9 authors, Ho Yong Park.
In Vivo, 2019 Oct 31; 33(6). PMID: 31662548    Free PMC article.
The significance of microbiome in personalized medicine.
Ava Behrouzi, Amir Hossein Nafari, Seyed Davar Siadat.
Clin Transl Med, 2019 May 14; 8(1). PMID: 31081530    Free PMC article.
Review.
High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer Patients.
Anna Trebo, Nina Ditsch, +8 authors, Anna Hester.
Cancers (Basel), 2020 Apr 16; 12(4). PMID: 32290551    Free PMC article.
The Role of PPARγ Ligands in Breast Cancer: From Basic Research to Clinical Studies.
Giuseppina Augimeri, Cinzia Giordano, +5 authors, Daniela Bonofiglio.
Cancers (Basel), 2020 Sep 18; 12(9). PMID: 32937951    Free PMC article.
Review.
SEOM clinical guidelines in early stage breast cancer (2018).
F Ayala de la Peña, R Andrés, +7 authors, E Ciruelos.
Clin Transl Oncol, 2018 Nov 18; 21(1). PMID: 30443868    Free PMC article.
Quantification of Breast Cancer Protein Biomarkers at Different Expression Levels in Human Tumors.
Yi Chen, David Britton, +8 authors, John M Koomen.
Methods Mol Biol, 2017 Dec 16; 1788. PMID: 29243084    Free PMC article.